| Disease ID | Disease name | Source of annotation with USP8 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 219090 | PITUITARY ADENOMA, ACTH-SECRETING | ClinVar | link to OMIM | 4 | USP8, AIP, GNAS, GNAI2 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Endocytosis | hsa04144 | 4.92 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Signaling by Wnt | R-HSA-195721 | 4.79 |
| Downregulation of ERBB2:ERBB3 signaling | R-HSA-1358803 | 9.28 |
| Signaling by ERBB2 | R-HSA-1227986 | 4.66 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 5.36 |
| regulation of FZD by ubiquitination | R-HSA-4641263 | 8.59 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| endopeptidase activity | GO:0004175 | 3.63 |
| ubiquitin-like protein-specific protease activity | GO:0019783 | 4.97 |
| ubiquitinyl hydrolase activity | GO:0101005 | 5.07 |
| SH3 domain binding | GO:0017124 | 4.98 |
| thiol-dependent ubiquitin-specific protease activity | GO:0004843 | 5.43 |
| catalytic activity | GO:0003824 | 1.05 |
| cysteine-type endopeptidase activity | GO:0004197 | 5.28 |
| cysteine-type peptidase activity | GO:0008234 | 4.51 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| peptidase activity | GO:0008233 | 3.23 |
| thiol-dependent ubiquitinyl hydrolase activity | GO:0036459 | 5.07 |
| protein domain specific binding | GO:0019904 | 3.32 |