Disease table of PITUITARY ADENOMA, ACTH-SECRETING OMIM ID: 219090

Gene-disease associations table

GeneAssociated with PITUITARY ADENOMA, ACTH-SECRETING inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
USP8ClinVarHGNC link15q21.21219090
GNAI2ClinVarHGNC link3p21.312219090, 192605
AIPClinVar, OMIMHGNC link11q13.23219090, 102200, 600634
GNASClinVarHGNC link20q13.329612463, 103580, 166350, 174800, 219080, 102200, 219090, 603233, 612462

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
AIPYES5AHR, TFF1, NFKB2, GREB1, RSF10
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
GNASYES1GATA10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
USP8GNAI2No2PTEN, KRT31
USP8AIPNo1EGFR
USP8GNASNo2NTRK1, EGFR
GNAI2AIPNo2HSP90AA1, HSP90AB1
GNAI2GNASNo19CCDC8, GNG5, ADRB2, CALML3, RIC8B, GNG10, TTC1, HAUS1, TBXA2R, GNB4, ACTB, MYH9, GNG4, SYNPO, CBX1, NUCB1, GNB2, TRIM69, GNB1
AIPGNASNo2GNAQ, EGFR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
USP8AIPNo-1UBC
USP8GNASNo-2SRC, UBC
GNAI2GNASNo-7ADCY1, GNGT2, RIC8A, GNB2, GNB4, GNG5, GNB1
AIPGNASNo-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Gastric acid secretionhsa049716.482GNAI2, GNAS
Platelet activationhsa046115.662GNAI2, GNAS
Gap junctionhsa045406.242GNAI2, GNAS
Morphine addictionhsa050326.152GNAI2, GNAS
Estrogen signaling pathwayhsa049156.112GNAI2, GNAS
Pathways in cancerhsa052003.982GNAI2, GNAS
cAMP signaling pathwayhsa040245.052GNAI2, GNAS
Adrenergic signaling in cardiomyocyteshsa042615.442GNAI2, GNAS
Chagas disease (American trypanosomiasis)hsa051425.992GNAI2, GNAS
Rap1 signaling pathwayhsa040154.972GNAI2, GNAS
Long-term depressionhsa047306.742GNAI2, GNAS
Melanogenesishsa049165.972GNAI2, GNAS
Glutamatergic synapsehsa047245.842GNAI2, GNAS
Alcoholismhsa050345.592GNAI2, GNAS
Serotonergic synapsehsa047265.842GNAI2, GNAS
Dopaminergic synapsehsa047285.692GNAI2, GNAS
Circadian entrainmenthsa047136.112GNAI2, GNAS
Cocaine addictionhsa050307.072GNAI2, GNAS
Oxytocin signaling pathwayhsa049215.42GNAI2, GNAS

NET-GE enrichment

Term New enriched termICP valueGenes
Platelet activation (hsa04611) -5.660.002GNAI2, GNAS
Calcium signaling pathway (hsa04020) NEW5.220.004GNAI2, GNAS
Cellular communityNEW3.570.017GNAI2, GNAS
cAMP signaling pathway (hsa04024) -5.050.01GNAI2, GNAS
Nervous systemNEW3.770.01AIP, GNAI2, GNAS
Excretory systemNEW5.450.002GNAI2, GNAS
Digestive systemNEW4.120.004GNAI2, GNAS
Circulatory systemNEW4.630.001GNAI2, GNAS
Taste transduction (hsa04742) NEW6.990.0GNAI2, GNAS
Serotonergic synapse (hsa04726) -5.840.001GNAI2, GNAS
Dopaminergic synapse (hsa04728) -5.690.0GNAI2, GNAS
Dilated cardiomyopathy (hsa05414) NEW6.080.002GNAI2, GNAS
Environmental adaptationNEW5.770.001GNAI2, GNAS
Infectious diseases: BacterialNEW3.760.01GNAI2, GNAS
Endocrine and other factor-regulated calcium reabsorption (hsa04961) NEW7.120.0GNAI2, GNAS
Chagas disease (American trypanosomiasis) (hsa05142) -5.990.0GNAI2, GNAS
Amoebiasis (hsa05146) NEW5.820.001GNAI2, GNAS
Oxytocin signaling pathway (hsa04921) -5.40.0GNAI2, GNAS
Vascular smooth muscle contraction (hsa04270) NEW5.740.004GNAI2, GNAS
Gap junction (hsa04540) -6.240.0GNAI2, GNAS
Substance dependenceNEW4.770.001GNAI2, GNAS
Cardiovascular diseasesNEW5.060.008GNAI2, GNAS
Inflammatory mediator regulation of TRP channels (hsa04750) NEW6.070.002GNAI2, GNAS
Infectious diseases: ParasiticNEW4.460.001GNAI2, GNAS
Pathways in cancer (hsa05200) -3.980.005GNAI2, GNAS
GnRH signaling pathway (hsa04912) NEW6.180.002GNAI2, GNAS
Rap1 signaling pathway (hsa04015) -4.970.015GNAI2, GNAS
Melanogenesis (hsa04916) -5.970.0GNAI2, GNAS
Estrogen signaling pathway (hsa04915) -6.110.0GNAI2, GNAS
Thyroid hormone synthesis (hsa04918) NEW6.560.0GNAI2, GNAS
Circadian entrainment (hsa04713) -6.110.0GNAI2, GNAS
Long-term depression (hsa04730) -6.740.0GNAI2, GNAS
Salivary secretion (hsa04970) NEW6.230.002GNAI2, GNAS
Gastric acid secretion (hsa04971) -6.480.0GNAI2, GNAS
Pancreatic secretion (hsa04972) NEW6.070.002GNAI2, GNAS
Endocrine systemNEW3.260.039GNAI2, GNAS
Cellular ProcessesNEW2.220.032GNAI2, GNAS, USP8
Morphine addiction (hsa05032) -6.150.0GNAI2, GNAS
Cocaine addiction (hsa05030) -7.070.0GNAI2, GNAS
Amphetamine addiction (hsa05031) NEW6.620.0GNAI2, GNAS
Alcoholism (hsa05034) -5.590.002GNAI2, GNAS
Adrenergic signaling in cardiomyocytes (hsa04261) -5.440.0GNAI2, GNAS
Glutamatergic synapse (hsa04724) -5.840.0GNAI2, GNAS
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.783GNAI2, GNAS, USP8
Regulation of insulin secretionR-HSA-4223566.662GNAI2, GNAS
Signaling by GPCRR-HSA-3727902.682GNAI2, GNAS
G alpha (i) signalling eventsR-HSA-4185945.12GNAI2, GNAS
G alpha (z) signalling eventsR-HSA-4185977.462GNAI2, GNAS
Integration of energy metabolismR-HSA-1636856.242GNAI2, GNAS
MetabolismR-HSA-14307282.342GNAI2, GNAS
GPCR downstream signalingR-HSA-3883963.072GNAI2, GNAS
G alpha (s) signalling eventsR-HSA-4185555.992GNAI2, GNAS
HemostasisR-HSA-1095823.982GNAI2, GNAS

NET-GE enrichment

Term New enriched termICP valueGenes
Phospholipase C-mediated cascade; FGFR2 (R-HSA-5654221) NEW7.370.046GNAI2, GNAS
Regulation of insulin secretion (R-HSA-422356) -6.660.013GNAI2, GNAS
Phospholipase C-mediated cascade; FGFR3 (R-HSA-5654227) NEW7.520.034GNAI2, GNAS
Adrenaline,noradrenaline inhibits insulin secretion (R-HSA-400042) NEW8.180.006GNAI2, GNAS
Phospholipase C-mediated cascade; FGFR4 (R-HSA-5654228) NEW7.460.037GNAI2, GNAS
G alpha (z) signalling events (R-HSA-418597) -7.460.019GNAI2, GNAS
Integration of energy metabolism (R-HSA-163685) -6.240.023GNAI2, GNAS
Aquaporin-mediated transport (R-HSA-445717) NEW7.310.037GNAI2, GNAS
GABA receptor activation (R-HSA-977443) NEW7.20.04GNAI2, GNAS
Phospholipase C-mediated cascade: FGFR1 (R-HSA-5654219) NEW7.430.047GNAI2, GNAS
Activation of GABAB receptors (R-HSA-991365) NEW7.70.016GNAI2, GNAS
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion (R-HSA-381676) NEW7.590.024GNAI2, GNAS
GABA B receptor activation (R-HSA-977444) NEW7.70.016GNAI2, GNAS
Vasopressin regulates renal water homeostasis via Aquaporins (R-HSA-432040) NEW7.560.023GNAI2, GNAS
G alpha (s) signalling events (R-HSA-418555) -5.990.033GNAI2, GNAS
Glucagon signaling in metabolic regulation (R-HSA-163359) NEW7.940.008GNAI2, GNAS
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.054AIP, GNAI2, GNAS, USP8
binding (GO:0005488) 0.184AIP, GNAI2, GNAS, USP8
protein binding (GO:0005515) 0.464AIP, GNAI2, GNAS, USP8
hydrolase activity (GO:0016787) 1.93GNAI2, GNAS, USP8
receptor binding (GO:0005102) 2.433AIP, GNAI2, GNAS
signal transducer activity (GO:0004871) 2.283AIP, GNAI2, GNAS
purine ribonucleoside triphosphate binding (GO:0035639) 2.222GNAI2, GNAS
macromolecular complex binding (GO:0044877) 2.612GNAI2, GNAS
G-protein coupled receptor binding (GO:0001664) 4.182GNAI2, GNAS
nucleotide binding (GO:0000166) 1.962GNAI2, GNAS
heterocyclic compound binding (GO:1901363) 1.062GNAI2, GNAS
purine nucleoside binding (GO:0001883) 2.222GNAI2, GNAS
nucleoside binding (GO:0001882) 2.212GNAI2, GNAS
cation binding (GO:0043169) 1.42GNAI2, GNAS
guanyl nucleotide binding (GO:0019001) 3.732GNAI2, GNAS
ion binding (GO:0043167) 1.362GNAI2, GNAS
guanyl ribonucleotide binding (GO:0032561) 3.732GNAI2, GNAS
nucleoside phosphate binding (GO:1901265) 1.962GNAI2, GNAS
ribonucleoside binding (GO:0032549) 2.222GNAI2, GNAS
protein complex binding (GO:0032403) 3.092GNAI2, GNAS
purine nucleotide binding (GO:0017076) 2.192GNAI2, GNAS
metal ion binding (GO:0046872) 1.412GNAI2, GNAS
GTP binding (GO:0005525) 3.782GNAI2, GNAS
G-protein beta/gamma-subunit complex binding (GO:0031683) 6.652GNAI2, GNAS
GTPase activity (GO:0003924) 4.312GNAI2, GNAS
nucleoside-triphosphatase activity (GO:0017111) 3.092GNAI2, GNAS
small molecule binding (GO:0036094) 1.892GNAI2, GNAS
protein domain specific binding (GO:0019904) 3.322AIP, USP8
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818) 3.032GNAI2, GNAS
carbohydrate derivative binding (GO:0097367) 2.032GNAI2, GNAS
organic cyclic compound binding (GO:0097159) 1.052GNAI2, GNAS
hydrolase activity, acting on acid anhydrides (GO:0016817) 3.032GNAI2, GNAS
pyrophosphatase activity (GO:0016462) 3.042GNAI2, GNAS
purine ribonucleotide binding (GO:0032555) 2.22GNAI2, GNAS
purine ribonucleoside binding (GO:0032550) 2.222GNAI2, GNAS
ribonucleotide binding (GO:0032553) 2.192GNAI2, GNAS

NET-GE enrichment

Term New enriched termICP valueGenes
alpha-2C adrenergic receptor binding (GO:0031696) NEW9.050.0GNAI2, GNAS
G-protein beta/gamma-subunit complex binding (GO:0031683) -6.650.0GNAI2, GNAS
D1 dopamine receptor binding (GO:0031748) NEW7.660.002GNAI2, GNAS
GTPase activity (GO:0003924) -4.310.003GNAI2, GNAS
phosphorus-oxygen lyase activity (GO:0016849) NEW6.60.009GNAI2, GNAS
guanyl ribonucleotide binding (GO:0032561) -3.730.021GNAI2, GNAS
dopamine receptor binding (GO:0050780) NEW6.850.005GNAI2, GNAS
guanyl nucleotide binding (GO:0019001) -3.730.021GNAI2, GNAS
GTP binding (GO:0005525) -3.780.018GNAI2, GNAS
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.264AIP, GNAI2, GNAS, USP8
regulation of cellular process (GO:0050794) 0.54AIP, GNAI2, GNAS, USP8
biological regulation (GO:0065007) 0.394AIP, GNAI2, GNAS, USP8
regulation of biological process (GO:0050789) 0.454AIP, GNAI2, GNAS, USP8
signal transduction (GO:0007165) 1.284AIP, GNAI2, GNAS, USP8
regulation of primary metabolic process (GO:0080090) 1.083AIP, GNAI2, GNAS
regulation of metabolic process (GO:0019222) 1.023AIP, GNAI2, GNAS
regulation of cellular biosynthetic process (GO:0031326) 1.383AIP, GNAI2, GNAS
regulation of response to stimulus (GO:0048583) 1.543AIP, GNAI2, GNAS
regulation of signaling (GO:0023051) 1.723AIP, GNAI2, GNAS
regulation of cell communication (GO:0010646) 1.733AIP, GNAI2, GNAS
single-organism process (GO:0044699) 0.483GNAI2, GNAS, USP8
cellular macromolecule metabolic process (GO:0044260) 0.933AIP, GNAS, USP8
regulation of signal transduction (GO:0009966) 1.843AIP, GNAI2, GNAS
organic substance metabolic process (GO:0071704) 0.633AIP, GNAS, USP8
regulation of molecular function (GO:0065009) 1.783AIP, GNAI2, GNAS
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433AIP, GNAI2, GNAS
regulation of cellular metabolic process (GO:0031323) 1.073AIP, GNAI2, GNAS
regulation of catalytic activity (GO:0050790) 1.973AIP, GNAI2, GNAS
regulation of biosynthetic process (GO:0009889) 1.373AIP, GNAI2, GNAS
macromolecule modification (GO:0043412) 1.733AIP, GNAS, USP8
single-organism cellular process (GO:0044763) 0.653GNAI2, GNAS, USP8
regulation of nitrogen compound metabolic process (GO:0051171) 1.363AIP, GNAI2, GNAS
metabolic process (GO:0008152) 0.583AIP, GNAS, USP8
regulation of intracellular signal transduction (GO:1902531) 2.313AIP, GNAI2, GNAS
primary metabolic process (GO:0044238) 0.693AIP, GNAS, USP8
regulation of macromolecule metabolic process (GO:0060255) 1.083AIP, GNAI2, GNAS
cellular metabolic process (GO:0044237) 0.693AIP, GNAS, USP8
macromolecule metabolic process (GO:0043170) 0.833AIP, GNAS, USP8
protein localization (GO:0008104) 2.362AIP, GNAS
protein folding (GO:0006457) 4.322AIP, GNAI2
positive regulation of metabolic process (GO:0009893) 1.742GNAI2, GNAS
regulation of transport (GO:0051049) 2.242GNAI2, GNAS
positive regulation of cellular metabolic process (GO:0031325) 1.812GNAI2, GNAS
positive regulation of response to stimulus (GO:0048584) 2.182GNAI2, GNAS
response to peptide (GO:1901652) 3.942GNAI2, GNAS
positive regulation of signaling (GO:0023056) 2.412GNAI2, GNAS
regulation of adenylate cyclase activity (GO:0045761) 5.512GNAI2, GNAS
cell surface receptor signaling pathway (GO:0007166) 2.092GNAI2, USP8
positive regulation of intracellular signal transduction (GO:1902533) 2.952GNAI2, GNAS
regulation of phosphate metabolic process (GO:0019220) 2.352GNAI2, GNAS
positive regulation of cell communication (GO:0010647) 2.412GNAI2, GNAS
regulation of lyase activity (GO:0051339) 5.32GNAI2, GNAS
negative regulation of catalytic activity (GO:0043086) 3.02AIP, GNAI2
cell cycle (GO:0007049) 3.142GNAI2, USP8
regulation of purine nucleotide metabolic process (GO:1900542) 4.412GNAI2, GNAS
response to endogenous stimulus (GO:0009719) 2.792GNAI2, GNAS
cellular protein metabolic process (GO:0044267) 1.632AIP, USP8
regulation of localization (GO:0032879) 1.942GNAI2, GNAS
regulation of cAMP biosynthetic process (GO:0030817) 5.012GNAI2, GNAS
regulation of cAMP metabolic process (GO:0030814) 4.882GNAI2, GNAS
response to nitrogen compound (GO:1901698) 3.122GNAI2, GNAS
localization (GO:0051179) 1.42AIP, GNAS
adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) 4.782GNAI2, GNAS
positive regulation of catalytic activity (GO:0043085) 2.42GNAI2, GNAS
positive regulation of molecular function (GO:0044093) 2.232GNAI2, GNAS
negative regulation of molecular function (GO:0044092) 2.742AIP, GNAI2
positive regulation of biological process (GO:0048518) 1.22GNAI2, GNAS
negative regulation of biological process (GO:0048519) 1.332GNAI2, GNAS
macromolecule localization (GO:0033036) 2.342AIP, GNAS
G-protein coupled receptor signaling pathway (GO:0007186) 2.642GNAI2, GNAS
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) 4.62GNAI2, GNAS
regulation of hydrolase activity (GO:0051336) 2.532AIP, GNAS
positive regulation of phosphate metabolic process (GO:0045937) 2.782GNAI2, GNAS
cell proliferation (GO:0008283) 3.232GNAI2, USP8
transport (GO:0006810) 1.512AIP, GNAS
cellular protein modification process (GO:0006464) 1.792AIP, USP8
establishment of protein localization (GO:0045184) 2.532AIP, GNAS
protein modification process (GO:0036211) 1.792AIP, USP8
response to organonitrogen compound (GO:0010243) 3.22GNAI2, GNAS
establishment of localization in cell (GO:0051649) 2.472AIP, GNAS
regulation of cyclic nucleotide metabolic process (GO:0030799) 4.692GNAI2, GNAS
response to chemical (GO:0042221) 1.982GNAI2, GNAS
response to peptide hormone (GO:0043434) 4.062GNAI2, GNAS
establishment of localization (GO:0051234) 1.482AIP, GNAS
regulation of cyclase activity (GO:0031279) 5.322GNAI2, GNAS
response to organic substance (GO:0010033) 2.22GNAI2, GNAS
cellular localization (GO:0051641) 2.322AIP, GNAS
response to oxygen-containing compound (GO:1901700) 2.572GNAI2, GNAS
regulation of phosphorus metabolic process (GO:0051174) 2.352GNAI2, GNAS
regulation of cyclic nucleotide biosynthetic process (GO:0030802) 4.852GNAI2, GNAS
regulation of nucleotide biosynthetic process (GO:0030808) 4.792GNAI2, GNAS
intracellular transport (GO:0046907) 2.672AIP, GNAS
protein metabolic process (GO:0019538) 1.452AIP, USP8
response to hormone (GO:0009725) 3.332GNAI2, GNAS
response to stimulus (GO:0050896) 1.222GNAI2, GNAS
regulation of purine nucleotide biosynthetic process (GO:1900371) 4.82GNAI2, GNAS
organic substance transport (GO:0071702) 2.152AIP, GNAS
positive regulation of signal transduction (GO:0009967) 2.52GNAI2, GNAS
protein transport (GO:0015031) 2.622AIP, GNAS
regulation of nucleotide metabolic process (GO:0006140) 4.382GNAI2, GNAS
positive regulation of phosphorus metabolic process (GO:0010562) 2.782GNAI2, GNAS
positive regulation of cellular process (GO:0048522) 1.32GNAI2, GNAS

NET-GE enrichment

Term New enriched termICP valueGenes
behavioral response to ethanol (GO:0048149) NEW7.530.019GNAI2, GNAS
GTP metabolic process (GO:0046039) NEW6.590.027GNAI2, GNAS
negative regulation of smooth muscle contraction (GO:0045986) NEW7.020.043GNAI2, GNAS
cellular response to glucagon stimulus (GO:0071377) NEW6.090.0GNAI2, GNAS
guanosine-containing compound catabolic process (GO:1901069) NEW8.630.023GNAI2, GNAS
guanosine-containing compound metabolic process (GO:1901068) NEW5.90.03GNAI2, GNAS
adenylate cyclase-modulating G-protein coupled receptor signaling pathway (GO:0007188) -4.780.002GNAI2, GNAS
adenylate cyclase-activating G-protein coupled receptor signaling pathway (GO:0007189) NEW5.520.001GNAI2, GNAS
response to prostaglandin (GO:0034694) NEW6.170.0GNAI2, GNAS
response to prostaglandin E (GO:0034695) NEW6.470.0GNAI2, GNAS
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger (GO:0007187) -4.60.005GNAI2, GNAS
G-protein coupled purinergic receptor signaling pathway (GO:0035588) NEW6.730.019GNAI2, GNAS
fluid transport (GO:0042044) NEW6.40.003GNAI2, GNAS
response to glucagon (GO:0033762) NEW5.840.002GNAI2, GNAS
water transport (GO:0006833) NEW6.680.002GNAI2, GNAS
adenosine receptor signaling pathway (GO:0001973) NEW7.530.006GNAI2, GNAS
adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) NEW7.240.009GNAI2, GNAS
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.014AIP, GNAI2, GNAS, USP8
cytosol (GO:0005829) 1.684AIP, GNAI2, GNAS, USP8
membrane (GO:0016020) 0.684AIP, GNAI2, GNAS, USP8
cell part (GO:0044464) 0.114AIP, GNAI2, GNAS, USP8
intracellular organelle part (GO:0044446) 0.814AIP, GNAI2, GNAS, USP8
cytoplasmic part (GO:0044444) 0.824AIP, GNAI2, GNAS, USP8
plasma membrane (GO:0005886) 1.394AIP, GNAI2, GNAS, USP8
intracellular part (GO:0044424) 0.284AIP, GNAI2, GNAS, USP8
organelle part (GO:0044422) 0.794AIP, GNAI2, GNAS, USP8
protein complex (GO:0043234) 1.513AIP, GNAI2, GNAS
macromolecular complex (GO:0032991) 1.353AIP, GNAI2, GNAS
intracellular membrane-bounded organelle (GO:0043231) 0.63GNAI2, GNAS, USP8
membrane-bounded organelle (GO:0043227) 0.473GNAI2, GNAS, USP8
nucleus (GO:0005634) 1.073GNAI2, GNAS, USP8
nucleoplasm (GO:0005654) 1.893AIP, GNAI2, USP8
intracellular organelle (GO:0043229) 0.513GNAI2, GNAS, USP8
nuclear part (GO:0044428) 1.553AIP, GNAI2, USP8
membrane part (GO:0044425) 0.953GNAI2, GNAS, USP8
plasma membrane part (GO:0044459) 1.953GNAI2, GNAS, USP8
organelle (GO:0043226) 0.43GNAI2, GNAS, USP8
extracellular vesicle (GO:1903561) 1.892GNAI2, GNAS
extracellular organelle (GO:0043230) 1.892GNAI2, GNAS
organelle membrane (GO:0031090) 1.972GNAS, USP8
neuron part (GO:0097458) 2.642GNAI2, GNAS
heterotrimeric G-protein complex (GO:0005834) 6.312GNAI2, GNAS
extracellular exosome (GO:0070062) 1.892GNAI2, GNAS
bounding membrane of organelle (GO:0098588) 2.392GNAS, USP8
catalytic complex (GO:1902494) 2.92GNAI2, GNAS
midbody (GO:0030496) 4.952GNAI2, USP8
dendrite (GO:0030425) 3.922GNAI2, GNAS
membrane-bounded vesicle (GO:0031988) 1.712GNAI2, GNAS
plasma membrane protein complex (GO:0098797) 3.552GNAI2, GNAS
membrane protein complex (GO:0098796) 2.842GNAI2, GNAS
neuron projection (GO:0043005) 3.122GNAI2, GNAS
cell projection (GO:0042995) 2.472GNAI2, GNAS
extracellular region part (GO:0044421) 1.572GNAI2, GNAS
vesicle (GO:0031982) 1.642GNAI2, GNAS

NET-GE enrichment

Term New enriched termICP valueGenes
heterotrimeric G-protein complex (GO:0005834) -6.310.006GNAI2, GNAS
cytosol (GO:0005829) -1.680.015AIP, GNAI2, GNAS, USP8
midbody (GO:0030496) -4.950.028GNAI2, USP8