Gene table of VWF : von Willebrand factor

Gene-disease associations table

Disease IDDisease nameSource of annotation with VWFOMIM linkNumber of associated genesgenes
613554VON WILLEBRAND DISEASE, TYPE 2ClinVar, OMIM, HUMSAVAR link to OMIM 1VWF
193400VON WILLEBRAND DISEASE, TYPE 1ClinVar, OMIM, HUMSAVAR link to OMIM 1VWF
277480VON WILLEBRAND DISEASE, TYPE 3OMIM, HUMSAVAR link to OMIM 1VWF

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Annotation of the gene VWF

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Platelet activationhsa046115.66
ECM-receptor interactionhsa045126.09
Complement and coagulation cascadeshsa046106.58
Focal adhesionhsa045104.92
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Downstream signaling of activated FGFR4R-HSA-56547164.71
Platelet degranulation R-HSA-1146086.68
Signaling by InterleukinsR-HSA-4491474.71
Signaling by LeptinR-HSA-25865525.1
Frs2-mediated activationR-HSA-1709685.12
MAP2K and MAPK activationR-HSA-56741357.66
Cytokine Signaling in Immune systemR-HSA-12802153.74
GP1b-IX-V activation signallingR-HSA-4301169.66
Extracellular matrix organizationR-HSA-14742444.91
IGF1R signaling cascadeR-HSA-24289244.85
Downstream signal transductionR-HSA-1867634.65
NCAM signaling for neurite out-growthR-HSA-3751654.9
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by ERBB4R-HSA-12363944.7
Innate Immune SystemR-HSA-1682493.17
IRS-mediated signallingR-HSA-1123994.87
MAPK1/MAPK3 signalingR-HSA-56849965.11
Developmental BiologyR-HSA-12667383.48
RAF/MAP kinase cascadeR-HSA-56730015.15
Integrin cell surface interactionsR-HSA-2160836.57
Platelet Aggregation (Plug Formation)R-HSA-760097.77
Downstream signaling of activated FGFR1R-HSA-56546874.71
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
Signaling by VEGFR-HSA-1941384.66
Signalling to p38 via RIT and RINR-HSA-1877065.12
Platelet activation, signaling and aggregationR-HSA-760025.15
FCERI mediated MAPK activationR-HSA-28717964.32
Response to elevated platelet cytosolic Ca2+R-HSA-760056.59
Signaling by EGFRR-HSA-1779294.59
p130Cas linkage to MAPK signaling for integrinsR-HSA-3727089.08
FRS-mediated FGFR2 signalingR-HSA-56547005.14
SOS-mediated signallingR-HSA-1124125.15
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Signaling by Insulin receptorR-HSA-747524.73
Downstream signaling of activated FGFR3R-HSA-56547084.71
Insulin receptor signalling cascadeR-HSA-747514.85
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Interleukin receptor SHC signalingR-HSA-9125265.09
Signaling by FGFRR-HSA-1902364.67
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Immune SystemR-HSA-1682562.37
SHC1 events in ERBB4 signalingR-HSA-12503475.15
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Signaling by SCF-KITR-HSA-14335574.73
Interleukin-2 signalingR-HSA-4519275.05
SHC1 events in ERBB2 signalingR-HSA-12501965.15
Signaling by ERBB2R-HSA-12279864.66
Signalling to RASR-HSA-1670445.08
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Platelet Adhesion to exposed collagenR-HSA-758929.08
Downstream signaling of activated FGFR2R-HSA-56546964.71
Signaling by FGFR1R-HSA-56547364.69
SHC1 events in EGFR signalingR-HSA-1803365.15
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Prolonged ERK activation eventsR-HSA-1698935.11
Formation of Fibrin Clot (Clotting Cascade)R-HSA-1408777.7
Signaling by GPCRR-HSA-3727902.68
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signalling to ERKsR-HSA-1876875.04
Integrin alphaIIb beta3 signalingR-HSA-3541928.23
ARMS-mediated activationR-HSA-1709845.12
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-3541949.08
DAP12 interactionsR-HSA-21721274.56
Intrinsic Pathway of Fibrin Clot FormationR-HSA-1408378.52
Signaling by PDGFR-HSA-1867974.53
Axon guidanceR-HSA-4224753.93
VEGFR2 mediated cell proliferationR-HSA-52189215.07
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
glycoprotein bindingGO:00019485.11
integrin bindingGO:00051785.07
cell adhesion molecule bindingGO:00508394.5
protease bindingGO:00020205.08
protein N-terminus bindingGO:00474855.11
carbohydrate derivative bindingGO:00973672.03
chaperone bindingGO:00510875.34
enzyme bindingGO:00198992.27
immunoglobulin bindingGO:00198656.6
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
protein bindingGO:00055150.46
protein complex bindingGO:00324033.09
protein dimerization activityGO:00469832.72
collagen bindingGO:00055185.58
receptor bindingGO:00051022.43
identical protein bindingGO:00428022.63
protein homodimerization activityGO:00428033.16