Gene table of NFKB1 : nuclear factor kappa B subunit 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with NFKB1OMIM linkNumber of associated genesgenes
PS607594IMMUNODEFICIENCY, COMMON VARIABLEClinVar, OMIM link to OMIM 12NFKB1, CD19, IL21, CR2, MS4A1, LRBA, NFKB2, CD81, IKZF1, TNFRSF13C, TNFRSF13B, ICOS

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Annotation of the gene NFKB1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Pertussishsa051336.46
Salmonella infectionhsa051326.29
Shigellosishsa051316.74
Legionellosishsa051346.88
Pancreatic cancerhsa052126.56
MAPK signaling pathwayhsa040104.63
cAMP signaling pathwayhsa040245.05
Prostate cancerhsa052156.11
Pathways in cancerhsa052003.98
Neurotrophin signaling pathwayhsa047225.78
Osteoclast differentiationhsa043805.64
HIF-1 signaling pathwayhsa040665.9
NF-kappa B signaling pathwayhsa040646.21
Chemokine signaling pathwayhsa040625.19
Adipocytokine signaling pathwayhsa049206.6
RIG-I-like receptor signaling pathwayhsa046226.62
Chagas disease (American trypanosomiasis)hsa051425.99
Leishmaniasishsa051406.32
Amoebiasishsa051465.82
Epstein-Barr virus infectionhsa051694.97
Toxoplasmosishsa051455.71
Influenza Ahsa051645.21
Herpes simplex infectionhsa051685.08
HTLV-I infectionhsa051664.59
Hepatitis Chsa051605.68
Hepatitis Bhsa051615.52
Measleshsa051625.6
Epithelial cell signaling in Helicobacter pylori infectionhsa051206.58
Apoptosishsa042106.23
MicroRNAs in cancerhsa052065.38
Inflammatory bowel disease (IBD)hsa053216.43
Toll-like receptor signaling pathwayhsa046206.0
NOD-like receptor signaling pathwayhsa046216.88
Viral carcinogenesishsa052035.08
Cytosolic DNA-sensing pathwayhsa046236.79
T cell receptor signaling pathwayhsa046606.01
B cell receptor signaling pathwayhsa046626.52
Ras signaling pathwayhsa040144.9
Prolactin signaling pathwayhsa049176.6
Acute myeloid leukemiahsa052216.74
Chronic myeloid leukemiahsa052206.48
TNF signaling pathwayhsa046685.96
Transcriptional misregulation in cancerhsa052025.21
Non-alcoholic fatty liver disease (NAFLD)hsa049325.51
PI3K-Akt signaling pathwayhsa041514.21
Cocaine addictionhsa050307.07
Tuberculosishsa051525.17
Small cell lung cancerhsa052226.17
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
C-type lectin receptors (CLRs)R-HSA-56214816.06
Cellular SenescenceR-HSA-25595835.7
Senescence-Associated Secretory Phenotype (SASP)R-HSA-25595826.77
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Immune SystemR-HSA-1682562.37
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
Cytokine Signaling in Immune systemR-HSA-12802153.74
Diseases associated with the TLR signaling cascadeR-HSA-56023588.34
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.7
p75 NTR receptor-mediated signallingR-HSA-1937046.59
Adaptive Immune SystemR-HSA-12802183.19
Developmental BiologyR-HSA-12667383.48
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-31349639.28
Signalling by NGFR-HSA-1665204.23
IkBA variant leads to EDA-IDR-HSA-560302910.18
Signaling by InterleukinsR-HSA-4491474.71
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Cellular responses to stressR-HSA-22627524.56
Toll-Like Receptors CascadesR-HSA-1688985.91
DiseaseR-HSA-16436853.33
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
NF-kB is activated and signals survivalR-HSA-2095609.28
ZBP1(DAI) mediated induction of type I IFNsR-HSA-16063228.28
Activation of NF-kappaB in B cellsR-HSA-11690916.94
TCR signalingR-HSA-2024036.64
Interleukin-1 signalingR-HSA-4466527.52
TRAF6 mediated NF-kB activationR-HSA-9335428.4
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
Transcriptional regulation of white adipocyte differentiationR-HSA-3813406.7
Downstream TCR signalingR-HSA-2024247.01
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Innate Immune SystemR-HSA-1682493.17
Regulated proteolysis of p75NTRR-HSA-1936929.66
p75NTR signals via NF-kBR-HSA-1936398.98
TAK1 activates NFkB by phosphorylation and activation of IKKs complexR-HSA-4459898.08
RIP-mediated NFkB activation via ZBP1R-HSA-18104768.59
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.94
Diseases of Immune SystemR-HSA-52602718.34
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)R-HSA-56030279.98
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
CLEC7A/inflammasome pathwayR-HSA-566066810.4
Interleukin-1 processingR-HSA-44870610.18
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
CD209 (DC-SIGN) signalingR-HSA-56215758.59
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
CLEC7A (Dectin-1) signalingR-HSA-56077646.38
Activated TLR4 signallingR-HSA-1660546.27
FCERI mediated NF-kB activationR-HSA-28718375.11
Signal TransductionR-HSA-1625821.78
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
Associated GO terms for Molecular function
GO termGO IDGO IC
heat shock protein bindingGO:00310725.24
RNA polymerase II regulatory region DNA bindingGO:00010123.36
enhancer sequence-specific DNA bindingGO:00011585.36
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
heterocyclic compound bindingGO:19013631.06
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:00037055.23
actinin bindingGO:00428056.3
double-stranded DNA bindingGO:00036903.09
identical protein bindingGO:00428022.63
RNA polymerase II distal enhancer sequence-specific DNA bindingGO:00009805.58
transcription factor bindingGO:00081343.46
regulatory region nucleic acid bindingGO:00010673.03
protein homodimerization activityGO:00428033.16
enhancer bindingGO:00353265.21
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific bindingGO:00012056.48
RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:00009813.29
transcription regulatory region DNA bindingGO:00442123.03
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012274.61
protein heterodimerization activityGO:00469823.64
cytoskeletal protein bindingGO:00080923.02
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingGO:00012283.98
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009773.37
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
protein dimerization activityGO:00469832.72
chromatin bindingGO:00036823.64
nucleic acid binding transcription factor activityGO:00010712.65