Disease table of LEIOMYOMA, UTERINE OMIM ID: 150699

Gene-disease associations table

GeneAssociated with LEIOMYOMA, UTERINE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MED12ClinVarHGNC linkXq13.14309520, 300895, 305450, 150699
HMGA2OMIMHGNC link12q14.31150699

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
HMGA2YES5HNF4A, IGF2BP2, SNAI1, POU1F1, CDH10
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HMGA2YES5SP1, SP3, BRCA1, ZNF382, ZNF3500
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
transcription regulatory region DNA binding (GO:0044212) 3.032HMGA2, MED12
sequence-specific double-stranded DNA binding (GO:1990837) 3.22HMGA2, MED12
transcription factor activity, transcription factor binding (GO:0000989) 3.362HMGA2, MED12
regulatory region DNA binding (GO:0000975) 3.032HMGA2, MED12
sequence-specific DNA binding (GO:0043565) 2.792HMGA2, MED12
organic cyclic compound binding (GO:0097159) 1.052HMGA2, MED12
transcription factor binding (GO:0008134) 3.462HMGA2, MED12
transcription factor activity, protein binding (GO:0000988) 3.352HMGA2, MED12
regulatory region nucleic acid binding (GO:0001067) 3.032HMGA2, MED12
protein binding (GO:0005515) 0.462HMGA2, MED12
catalytic activity (GO:0003824) 1.052HMGA2, MED12
transferase activity (GO:0016740) 1.952HMGA2, MED12
macromolecular complex binding (GO:0044877) 2.612HMGA2, MED12
protein domain specific binding (GO:0019904) 3.322HMGA2, MED12
nucleic acid binding (GO:0003676) 1.442HMGA2, MED12
DNA binding (GO:0003677) 1.922HMGA2, MED12
double-stranded DNA binding (GO:0003690) 3.092HMGA2, MED12
chromatin binding (GO:0003682) 3.642HMGA2, MED12
heterocyclic compound binding (GO:1901363) 1.062HMGA2, MED12
binding (GO:0005488) 0.182HMGA2, MED12

NET-GE enrichment

Term New enriched termICP valueGenes
transcription factor binding (GO:0008134) -3.460.049HMGA2, MED12
chromatin binding (GO:0003682) -3.640.04HMGA2, MED12
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of primary metabolic process (GO:0080090) 1.082HMGA2, MED12
regulation of metabolic process (GO:0019222) 1.022HMGA2, MED12
negative regulation of response to stimulus (GO:0048585) 2.522HMGA2, MED12
regulation of response to stimulus (GO:0048583) 1.542HMGA2, MED12
signal transduction (GO:0007165) 1.282HMGA2, MED12
organic cyclic compound biosynthetic process (GO:1901362) 1.662HMGA2, MED12
organic cyclic compound metabolic process (GO:1901360) 1.262HMGA2, MED12
positive regulation of macromolecule metabolic process (GO:0010604) 1.812HMGA2, MED12
negative regulation of signal transduction (GO:0009968) 2.752HMGA2, MED12
regulation of signal transduction (GO:0009966) 1.842HMGA2, MED12
cellular developmental process (GO:0048869) 1.822HMGA2, MED12
animal organ development (GO:0048513) 2.532HMGA2, MED12
positive regulation of biological process (GO:0048518) 1.22HMGA2, MED12
negative regulation of biological process (GO:0048519) 1.332HMGA2, MED12
positive regulation of RNA biosynthetic process (GO:1902680) 2.542HMGA2, MED12
regulation of macromolecule metabolic process (GO:0060255) 1.082HMGA2, MED12
regulation of RNA biosynthetic process (GO:2001141) 1.552HMGA2, MED12
heterocycle metabolic process (GO:0046483) 1.312HMGA2, MED12
stem cell population maintenance (GO:0019827) 4.832HMGA2, MED12
single-multicellular organism process (GO:0044707) 1.782HMGA2, MED12
negative regulation of signaling (GO:0023057) 2.652HMGA2, MED12
protein metabolic process (GO:0019538) 1.452HMGA2, MED12
aromatic compound biosynthetic process (GO:0019438) 1.72HMGA2, MED12
positive regulation of metabolic process (GO:0009893) 1.742HMGA2, MED12
positive regulation of biosynthetic process (GO:0009891) 2.292HMGA2, MED12
nitrogen compound metabolic process (GO:0006807) 1.132HMGA2, MED12
regulation of biological process (GO:0050789) 0.452HMGA2, MED12
nucleic acid-templated transcription (GO:0097659) 1.912HMGA2, MED12
organic substance biosynthetic process (GO:1901576) 1.342HMGA2, MED12
anatomical structure morphogenesis (GO:0009653) 2.532HMGA2, MED12
cellular macromolecule metabolic process (GO:0044260) 0.932HMGA2, MED12
biological regulation (GO:0065007) 0.392HMGA2, MED12
heterocycle biosynthetic process (GO:0018130) 1.72HMGA2, MED12
regulation of developmental process (GO:0050793) 2.12HMGA2, MED12
regulation of biosynthetic process (GO:0009889) 1.372HMGA2, MED12
tissue development (GO:0009888) 3.272HMGA2, MED12
regulation of cellular process (GO:0050794) 0.52HMGA2, MED12
maintenance of cell number (GO:0098727) 4.822HMGA2, MED12
macromolecule modification (GO:0043412) 1.732HMGA2, MED12
protein modification process (GO:0036211) 1.792HMGA2, MED12
metabolic process (GO:0008152) 0.582HMGA2, MED12
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722HMGA2, MED12
RNA metabolic process (GO:0016070) 1.592HMGA2, MED12
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592HMGA2, MED12
regulation of transcription, DNA-templated (GO:0006355) 1.562HMGA2, MED12
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392HMGA2, MED12
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242HMGA2, MED12
transcription, DNA-templated (GO:0006351) 1.912HMGA2, MED12
RNA biosynthetic process (GO:0032774) 1.842HMGA2, MED12
cellular biosynthetic process (GO:0044249) 1.372HMGA2, MED12
cellular nitrogen compound metabolic process (GO:0034641) 1.222HMGA2, MED12
negative regulation of cell communication (GO:0010648) 2.662HMGA2, MED12
cellular macromolecule biosynthetic process (GO:0034645) 1.662HMGA2, MED12
regulation of signaling (GO:0023051) 1.722HMGA2, MED12
regulation of cell communication (GO:0010646) 1.732HMGA2, MED12
single-organism process (GO:0044699) 0.482HMGA2, MED12
nucleobase-containing compound metabolic process (GO:0006139) 1.352HMGA2, MED12
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562HMGA2, MED12
multicellular organismal process (GO:0032501) 1.452HMGA2, MED12
cellular process (GO:0009987) 0.262HMGA2, MED12
cellular aromatic compound metabolic process (GO:0006725) 1.32HMGA2, MED12
regulation of nucleic acid-templated transcription (GO:1903506) 1.552HMGA2, MED12
positive regulation of transcription, DNA-templated (GO:0045893) 2.562HMGA2, MED12
regulation of RNA metabolic process (GO:0051252) 1.522HMGA2, MED12
positive regulation of RNA metabolic process (GO:0051254) 2.512HMGA2, MED12
macromolecule metabolic process (GO:0043170) 0.832HMGA2, MED12
regulation of multicellular organismal process (GO:0051239) 1.872HMGA2, MED12
positive regulation of gene expression (GO:0010628) 2.352HMGA2, MED12
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812HMGA2, MED12
developmental process (GO:0032502) 1.362HMGA2, MED12
positive regulation of cellular biosynthetic process (GO:0031328) 2.32HMGA2, MED12
regulation of cellular biosynthetic process (GO:0031326) 1.382HMGA2, MED12
positive regulation of cellular metabolic process (GO:0031325) 1.812HMGA2, MED12
regulation of cellular metabolic process (GO:0031323) 1.072HMGA2, MED12
nucleic acid metabolic process (GO:0090304) 1.462HMGA2, MED12
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462HMGA2, MED12
organic substance metabolic process (GO:0071704) 0.632HMGA2, MED12
regulation of macromolecule biosynthetic process (GO:0010556) 1.432HMGA2, MED12
regulation of gene expression (GO:0010468) 1.372HMGA2, MED12
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352HMGA2, MED12
cellular protein metabolic process (GO:0044267) 1.632HMGA2, MED12
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432HMGA2, MED12
cellular protein modification process (GO:0006464) 1.792HMGA2, MED12
single-organism developmental process (GO:0044767) 1.492HMGA2, MED12
biosynthetic process (GO:0009058) 1.322HMGA2, MED12
macromolecule biosynthetic process (GO:0009059) 1.612HMGA2, MED12
single-organism cellular process (GO:0044763) 0.652HMGA2, MED12
regulation of nitrogen compound metabolic process (GO:0051171) 1.362HMGA2, MED12
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292HMGA2, MED12
primary metabolic process (GO:0044238) 0.692HMGA2, MED12
anatomical structure development (GO:0048856) 1.582HMGA2, MED12
cellular metabolic process (GO:0044237) 0.692HMGA2, MED12
regulation of multicellular organismal development (GO:2000026) 2.312HMGA2, MED12
negative regulation of cellular process (GO:0048523) 1.412HMGA2, MED12
positive regulation of cellular process (GO:0048522) 1.32HMGA2, MED12

NET-GE enrichment

Term New enriched termICP valueGenes
stem cell maintenance (GO:0019827) -4.830.013HMGA2, MED12
regulation of DNA repair (GO:0006282) NEW5.40.016HMGA2, MED12
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein complex (GO:0043234) 1.512HMGA2, MED12
intracellular organelle part (GO:0044446) 0.812HMGA2, MED12
macromolecular complex (GO:0032991) 1.352HMGA2, MED12
intracellular membrane-bounded organelle (GO:0043231) 0.62HMGA2, MED12
intracellular non-membrane-bounded organelle (GO:0043232) 1.762HMGA2, MED12
nucleus (GO:0005634) 1.072HMGA2, MED12
cell part (GO:0044464) 0.112HMGA2, MED12
nucleoplasm (GO:0005654) 1.892HMGA2, MED12
intracellular organelle (GO:0043229) 0.512HMGA2, MED12
non-membrane-bounded organelle (GO:0043228) 1.762HMGA2, MED12
nuclear part (GO:0044428) 1.552HMGA2, MED12
intracellular part (GO:0044424) 0.282HMGA2, MED12
membrane-bounded organelle (GO:0043227) 0.472HMGA2, MED12
organelle (GO:0043226) 0.42HMGA2, MED12
organelle part (GO:0044422) 0.792HMGA2, MED12

NET-GE enrichment

Term New enriched termICP valueGenes
protein-DNA complex (GO:0032993) NEW5.030.008HMGA2, MED12
nuclear chromosome part (GO:0044454) NEW3.670.044HMGA2, MED12
nuclear chromatin (GO:0000790) NEW4.420.013HMGA2, MED12
chromatin (GO:0000785) NEW3.990.035HMGA2, MED12
chromosome (GO:0005694) NEW3.780.011HMGA2, MED12