Disease table of PROPIONIC ACIDEMIA OMIM ID: 606054

Gene-disease associations table

GeneAssociated with PROPIONIC ACIDEMIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
PCCBOMIM, HUMSAVARHGNC link3q22.31606054
PCCAOMIM, HUMSAVARHGNC link13q32.31606054

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PCCBPCCAYes6EBNA-LP, UBE2N, HUWE1, IFIT1, PTEN, PARK2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
PCCBPCCAYesbinding3HLCS, ACACB, ACACA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
PCCAPCCBmaybeThey are the alpha and beta chains of Propionyl-CoA carboxylase. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Valine, leucine and isoleucine degradationhsa002807.092PCCA, PCCB
Glyoxylate and dicarboxylate metabolismhsa006308.072PCCA, PCCB
Propanoate metabolismhsa006407.812PCCA, PCCB
Metabolic pathwayshsa011002.492PCCA, PCCB

NET-GE enrichment

Term New enriched termICP valueGenes
Glyoxylate and dicarboxylate metabolism (hsa00630) -8.070.0PCCA, PCCB
Propanoate metabolism (hsa00640) -7.810.0PCCA, PCCB
Amino acid metabolismNEW4.630.044PCCA, PCCB
Carbohydrate metabolismNEW4.360.04PCCA, PCCB
Valine, leucine and isoleucine degradation (hsa00280) -7.090.001PCCA, PCCB
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Mitochondrial Fatty Acid Beta-OxidationR-HSA-772899.082PCCA, PCCB
Defects in biotin (Btn) metabolismR-HSA-33231699.812PCCA, PCCB
Metabolism of water-soluble vitamins and cofactorsR-HSA-1968496.542PCCA, PCCB
Metabolism of vitamins and cofactorsR-HSA-1968546.542PCCA, PCCB
Propionyl-CoA catabolismR-HSA-7103210.662PCCA, PCCB
Diseases of metabolismR-HSA-56689146.572PCCA, PCCB
Defective HLCS causes multiple carboxylase deficiencyR-HSA-33715999.982PCCA, PCCB
MetabolismR-HSA-14307282.342PCCA, PCCB
Fatty acid, triacylglycerol, and ketone body metabolismR-HSA-5357345.442PCCA, PCCB
Metabolism of lipids and lipoproteinsR-HSA-5568333.792PCCA, PCCB
Defects in vitamin and cofactor metabolismR-HSA-32964828.522PCCA, PCCB
DiseaseR-HSA-16436853.332PCCA, PCCB
Biotin transport and metabolismR-HSA-1967809.522PCCA, PCCB

NET-GE enrichment

Term New enriched termICP valueGenes
Mitochondrial Fatty Acid Beta-Oxidation (R-HSA-77289) -9.080.0PCCA, PCCB
Defects in biotin (Btn) metabolism (R-HSA-3323169) -9.810.0PCCA, PCCB
Metabolism of water-soluble vitamins and cofactors (R-HSA-196849) -6.540.002PCCA, PCCB
Metabolism of vitamins and cofactors (R-HSA-196854) -6.540.002PCCA, PCCB
Propionyl-CoA catabolism (R-HSA-71032) -10.660.0PCCA, PCCB
Diseases of metabolism (R-HSA-5668914) -6.570.002PCCA, PCCB
Defective HLCS causes multiple carboxylase deficiency (R-HSA-3371599) -9.980.0PCCA, PCCB
Fatty acid, triacylglycerol, and ketone body metabolism (R-HSA-535734) -5.440.027PCCA, PCCB
Defects in vitamin and cofactor metabolism (R-HSA-3296482) -8.520.0PCCA, PCCB
Biotin transport and metabolism (R-HSA-196780) -9.520.0PCCA, PCCB
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
purine ribonucleoside triphosphate binding (GO:0035639) 2.222PCCA, PCCB
ligase activity, forming carbon-carbon bonds (GO:0016885) 7.792PCCA, PCCB
binding (GO:0005488) 0.182PCCA, PCCB
heterocyclic compound binding (GO:1901363) 1.062PCCA, PCCB
nucleoside phosphate binding (GO:1901265) 1.962PCCA, PCCB
nucleoside binding (GO:0001882) 2.212PCCA, PCCB
propionyl-CoA carboxylase activity (GO:0004658) 9.052PCCA, PCCB
nucleotide binding (GO:0000166) 1.962PCCA, PCCB
purine nucleoside binding (GO:0001883) 2.222PCCA, PCCB
ribonucleoside binding (GO:0032549) 2.222PCCA, PCCB
purine nucleotide binding (GO:0017076) 2.192PCCA, PCCB
ATP binding (GO:0005524) 2.432PCCA, PCCB
small molecule binding (GO:0036094) 1.892PCCA, PCCB
catalytic activity (GO:0003824) 1.052PCCA, PCCB
ligase activity (GO:0016874) 3.722PCCA, PCCB
adenyl nucleotide binding (GO:0030554) 2.42PCCA, PCCB
carbohydrate derivative binding (GO:0097367) 2.032PCCA, PCCB
organic cyclic compound binding (GO:0097159) 1.052PCCA, PCCB
CoA carboxylase activity (GO:0016421) 7.952PCCA, PCCB
adenyl ribonucleotide binding (GO:0032559) 2.412PCCA, PCCB
purine ribonucleotide binding (GO:0032555) 2.22PCCA, PCCB
purine ribonucleoside binding (GO:0032550) 2.222PCCA, PCCB
ribonucleotide binding (GO:0032553) 2.192PCCA, PCCB

NET-GE enrichment

Term New enriched termICP valueGenes
propionyl-CoA carboxylase activity (GO:0004658) -9.050.0PCCA, PCCB
CoA carboxylase activity (GO:0016421) -7.950.0PCCA, PCCB
ligase activity, forming carbon-carbon bonds (GO:0016885) -7.790.0PCCA, PCCB
ligase activity (GO:0016874) -3.720.026PCCA, PCCB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
fatty acid metabolic process (GO:0006631) 4.032PCCA, PCCB
carboxylic acid metabolic process (GO:0019752) 3.122PCCA, PCCB
cellular catabolic process (GO:0044248) 2.622PCCA, PCCB
fatty acid catabolic process (GO:0009062) 5.482PCCA, PCCB
small molecule metabolic process (GO:0044281) 2.382PCCA, PCCB
small molecule catabolic process (GO:0044282) 3.992PCCA, PCCB
cellular lipid catabolic process (GO:0044242) 4.732PCCA, PCCB
single-organism process (GO:0044699) 0.482PCCA, PCCB
single-organism catabolic process (GO:0044712) 3.212PCCA, PCCB
single-organism metabolic process (GO:0044710) 1.632PCCA, PCCB
cofactor metabolic process (GO:0051186) 3.912PCCA, PCCB
lipid catabolic process (GO:0016042) 4.212PCCA, PCCB
organic substance metabolic process (GO:0071704) 0.632PCCA, PCCB
organic substance catabolic process (GO:1901575) 2.452PCCA, PCCB
short-chain fatty acid catabolic process (GO:0019626) 7.942PCCA, PCCB
water-soluble vitamin metabolic process (GO:0006767) 5.292PCCA, PCCB
vitamin metabolic process (GO:0006766) 4.972PCCA, PCCB
lipid metabolic process (GO:0006629) 2.682PCCA, PCCB
cellular process (GO:0009987) 0.262PCCA, PCCB
biotin metabolic process (GO:0006768) 7.092PCCA, PCCB
monocarboxylic acid metabolic process (GO:0032787) 3.572PCCA, PCCB
single-organism cellular process (GO:0044763) 0.652PCCA, PCCB
metabolic process (GO:0008152) 0.582PCCA, PCCB
monocarboxylic acid catabolic process (GO:0072329) 5.262PCCA, PCCB
oxoacid metabolic process (GO:0043436) 3.122PCCA, PCCB
cellular lipid metabolic process (GO:0044255) 2.922PCCA, PCCB
catabolic process (GO:0009056) 2.382PCCA, PCCB
primary metabolic process (GO:0044238) 0.692PCCA, PCCB
organic acid metabolic process (GO:0006082) 3.012PCCA, PCCB
carboxylic acid catabolic process (GO:0046395) 4.582PCCA, PCCB
organic acid catabolic process (GO:0016054) 4.442PCCA, PCCB
cellular metabolic process (GO:0044237) 0.692PCCA, PCCB
short-chain fatty acid metabolic process (GO:0046459) 7.092PCCA, PCCB

NET-GE enrichment

Term New enriched termICP valueGenes
lipid oxidation (GO:0034440) NEW5.470.001PCCA, PCCB
fatty acid metabolic process (GO:0006631) -4.030.016PCCA, PCCB
fatty acid beta-oxidation (GO:0006635) NEW5.780.002PCCA, PCCB
fatty acid catabolic process (GO:0009062) -5.480.004PCCA, PCCB
small molecule catabolic process (GO:0044282) -3.990.014PCCA, PCCB
fatty acid oxidation (GO:0019395) NEW5.480.003PCCA, PCCB
cellular lipid catabolic process (GO:0044242) -4.730.019PCCA, PCCB
lipid catabolic process (GO:0016042) -4.210.011PCCA, PCCB
short-chain fatty acid catabolic process (GO:0019626) -7.940.0PCCA, PCCB
water-soluble vitamin metabolic process (GO:0006767) -5.290.002PCCA, PCCB
vitamin metabolic process (GO:0006766) -4.970.003PCCA, PCCB
biotin metabolic process (GO:0006768) -7.090.0PCCA, PCCB
monocarboxylic acid metabolic process (GO:0032787) -3.570.046PCCA, PCCB
cofactor metabolic process (GO:0051186) -3.910.015PCCA, PCCB
monocarboxylic acid catabolic process (GO:0072329) -5.260.001PCCA, PCCB
lipid modification (GO:0030258) NEW4.370.017PCCA, PCCB
cellular amide metabolic process (GO:0043603) NEW3.230.02PCCA, PCCB
carboxylic acid catabolic process (GO:0046395) -4.580.008PCCA, PCCB
organic acid catabolic process (GO:0016054) -4.440.008PCCA, PCCB
sulfur compound metabolic process (GO:0006790) NEW3.870.02PCCA, PCCB
short-chain fatty acid metabolic process (GO:0046459) -7.090.0PCCA, PCCB
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.62PCCA, PCCB
organelle lumen (GO:0043233) 3.052PCCA, PCCB
cytosol (GO:0005829) 1.682PCCA, PCCB
cell part (GO:0044464) 0.112PCCA, PCCB
intracellular organelle (GO:0043229) 0.512PCCA, PCCB
membrane-enclosed lumen (GO:0031974) 3.052PCCA, PCCB
intracellular organelle part (GO:0044446) 0.812PCCA, PCCB
intracellular organelle lumen (GO:0070013) 3.052PCCA, PCCB
cytoplasmic part (GO:0044444) 0.822PCCA, PCCB
mitochondrion (GO:0005739) 2.422PCCA, PCCB
mitochondrial part (GO:0044429) 2.922PCCA, PCCB
mitochondrial matrix (GO:0005759) 4.032PCCA, PCCB
intracellular part (GO:0044424) 0.282PCCA, PCCB
membrane-bounded organelle (GO:0043227) 0.472PCCA, PCCB
organelle (GO:0043226) 0.42PCCA, PCCB
organelle part (GO:0044422) 0.792PCCA, PCCB

NET-GE enrichment

Term New enriched termICP valueGenes
mitochondrial matrix (GO:0005759) -4.030.008PCCA, PCCB
intracellular organelle lumen (GO:0070013) -3.050.016PCCA, PCCB
mitochondrial part (GO:0044429) -2.920.035PCCA, PCCB
membrane-enclosed lumen (GO:0031974) -3.050.024PCCA, PCCB
organelle lumen (GO:0043233) -3.050.02PCCA, PCCB