Gene table of PARK2 : parkin RBR E3 ubiquitin protein ligase

Gene-disease associations table

Disease IDDisease nameSource of annotation with PARK2OMIM linkNumber of associated genesgenes
PS168600PARKINSON DISEASEClinVar, OMIM, HUMSAVAR link to OMIM 30ATP13A2, FGF20, VPS13C, DNAJC13, ATXN2, PINK1, CHCHD2, ADH1C, UCHL1, GIGYF2, SYNJ1, PODXL, HTRA2, LRRK2, TBP, PARK2, ATXN8OS, SNCAIP, GBA, SNCA, NR4A2, PLA2G6, GLUD2, PARK7, ATXN3, MAPT, DNAJC6, EIF4G1, FBXO7, VPS35
607572LEPROSY, SUSCEPTIBILITY TO, 2OMIM link to OMIM 1PARK2
211980LUNG CANCEROMIM link to OMIM 17RASSF1, PARK2, IRF1, DLEC1, ERBB2, CYP2A6, PPP2R1B, MAP3K8, PIK3CA, BRAF, KRAS, SLC22A18, ERCC6, FASLG, CASP8, MXRA5, EGFR
167000OVARIAN CANCEROMIM link to OMIM 9AKT1, PARK2, CTNNB1, CDH1, BRCA1, RRAS2, PIK3CA, OPCML, SEPT9

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Annotation of the gene PARK2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Protein processing in endoplasmic reticulumhsa041415.35
Parkinson's diseasehsa050125.59
Ubiquitin mediated proteolysishsa041205.63
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Class I MHC mediated antigen processing & presentationR-HSA-9831694.65
Antigen processing: Ubiquitination & Proteasome degradationR-HSA-9831685.19
Immune SystemR-HSA-1682562.37
Adaptive Immune SystemR-HSA-12802183.19
Associated GO terms for Molecular function
GO termGO IDGO IC
ubiquitin-specific protease bindingGO:19903817.25
ubiquitin-like protein ligase bindingGO:00443894.15
ubiquitin protein ligase activity involved in ERAD pathwayGO:19042647.54
heat shock protein bindingGO:00310725.24
SH3 domain bindingGO:00171244.98
enzyme bindingGO:00198992.27
kinase bindingGO:00199003.32
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
G-protein coupled receptor bindingGO:00016644.18
heterocyclic compound bindingGO:19013631.06
ubiquitin-like protein transferase activityGO:00197873.69
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
transition metal ion bindingGO:00469142.48
Hsp70 protein bindingGO:00305446.37
ubiquitin protein ligase activityGO:00616304.47
chaperone bindingGO:00510875.34
ion bindingGO:00431671.36
actin bindingGO:00037793.74
transferase activityGO:00167401.95
protease bindingGO:00020205.08
double-stranded DNA bindingGO:00036903.09
metal ion bindingGO:00468721.41
histone deacetylase bindingGO:00428265.08
identical protein bindingGO:00428022.63
tubulin bindingGO:00156314.1
ubiquitin-like protein conjugating enzyme bindingGO:00443906.21
F-box domain bindingGO:19904449.74
nucleic acid binding transcription factor activityGO:00010712.65
cation bindingGO:00431691.4
regulatory region nucleic acid bindingGO:00010673.03
beta-catenin bindingGO:00080135.3
protein kinase bindingGO:00199013.44
catalytic activityGO:00038241.05
PDZ domain bindingGO:00301655.22
ubiquitin-protein transferase activityGO:00048423.73
protein domain specific bindingGO:00199043.32
ligase activityGO:00168743.72
ubiquitin-like protein ligase activityGO:00616594.44
transcription regulatory region DNA bindingGO:00442123.03
ubiquitin conjugating enzyme bindingGO:00316246.3
ubiquitin protein ligase bindingGO:00316254.17
cullin family protein bindingGO:00976027.25
cytoskeletal protein bindingGO:00080923.02
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
ubiquitin-like protein bindingGO:00321824.93
ubiquitin bindingGO:00431305.09
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
phospholipase bindingGO:00432746.91
receptor bindingGO:00051022.43
zinc ion bindingGO:00082702.66