Disease table of FRONTONASAL DYSPLASIA OMIM ID: PS136760

Gene-disease associations table

GeneAssociated with FRONTONASAL DYSPLASIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ALX3ClinVar, OMIM, HUMSAVARHGNC link1p13.31PS136760
ALX1ClinVar, OMIMHGNC link12q21.311PS136760
ALX4ClinVar, OMIMHGNC link11p11.23PS136760, 615529, 609597

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
ALX4YES1LEF10
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ALX3ALX4No-1SRF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
sequence-specific DNA binding (GO:0043565) 2.793ALX1, ALX4, ALX3
organic cyclic compound binding (GO:0097159) 1.053ALX1, ALX4, ALX3
binding (GO:0005488) 0.183ALX1, ALX4, ALX3
nucleic acid binding (GO:0003676) 1.443ALX1, ALX4, ALX3
DNA binding (GO:0003677) 1.923ALX1, ALX4, ALX3
heterocyclic compound binding (GO:1901363) 1.063ALX1, ALX4, ALX3
transcription regulatory region DNA binding (GO:0044212) 3.032ALX1, ALX4
sequence-specific double-stranded DNA binding (GO:1990837) 3.22ALX1, ALX4
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652ALX1, ALX4
RNA polymerase II regulatory region DNA binding (GO:0001012) 3.362ALX1, ALX4
regulatory region nucleic acid binding (GO:0001067) 3.032ALX1, ALX4
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228) 3.982ALX1, ALX4
transcription regulatory region sequence-specific DNA binding (GO:0000976) 3.242ALX1, ALX4
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977) 3.372ALX1, ALX4
protein binding (GO:0005515) 0.462ALX1, ALX4
regulatory region DNA binding (GO:0000975) 3.032ALX1, ALX4
double-stranded DNA binding (GO:0003690) 3.092ALX1, ALX4
protein heterodimerization activity (GO:0046982) 3.642ALX1, ALX4
protein dimerization activity (GO:0046983) 2.722ALX1, ALX4
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292ALX1, ALX4
nucleic acid binding transcription factor activity (GO:0001071) 2.652ALX1, ALX4

NET-GE enrichment

Term New enriched termICP valueGenes
sequence-specific DNA binding (GO:0043565) -2.790.002ALX1, ALX4, ALX3
protein heterodimerization activity (GO:0046982) -3.640.025ALX1, ALX4, ALX3
sequence-specific DNA binding RNA polymerase II transcription factor activity (GO:0000981) -3.290.012ALX1, ALX4, ALX3
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.363ALX1, ALX4, ALX3
limb morphogenesis (GO:0035108) 5.053ALX1, ALX4, ALX3
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433ALX1, ALX4, ALX3
regulation of primary metabolic process (GO:0080090) 1.083ALX1, ALX4, ALX3
regulation of metabolic process (GO:0019222) 1.023ALX1, ALX4, ALX3
regulation of cellular biosynthetic process (GO:0031326) 1.383ALX1, ALX4, ALX3
embryonic appendage morphogenesis (GO:0035113) 5.243ALX1, ALX4, ALX3
appendage morphogenesis (GO:0035107) 5.053ALX1, ALX4, ALX3
nucleic acid metabolic process (GO:0090304) 1.463ALX1, ALX4, ALX3
cellular biosynthetic process (GO:0044249) 1.373ALX1, ALX4, ALX3
cellular nitrogen compound metabolic process (GO:0034641) 1.223ALX1, ALX4, ALX3
embryonic organ morphogenesis (GO:0048562) 4.923ALX1, ALX4, ALX3
cellular macromolecule biosynthetic process (GO:0034645) 1.663ALX1, ALX4, ALX3
anatomical structure morphogenesis (GO:0009653) 2.533ALX1, ALX4, ALX3
organic cyclic compound biosynthetic process (GO:1901362) 1.663ALX1, ALX4, ALX3
regulation of biological process (GO:0050789) 0.453ALX1, ALX4, ALX3
nucleic acid-templated transcription (GO:0097659) 1.913ALX1, ALX4, ALX3
RNA biosynthetic process (GO:0032774) 1.843ALX1, ALX4, ALX3
organic substance biosynthetic process (GO:1901576) 1.343ALX1, ALX4, ALX3
embryonic limb morphogenesis (GO:0030326) 5.243ALX1, ALX4, ALX3
cellular macromolecule metabolic process (GO:0044260) 0.933ALX1, ALX4, ALX3
regulation of cellular metabolic process (GO:0031323) 1.073ALX1, ALX4, ALX3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463ALX1, ALX4, ALX3
multicellular organism development (GO:0007275) 2.543ALX1, ALX4, ALX3
organic substance metabolic process (GO:0071704) 0.633ALX1, ALX4, ALX3
regulation of macromolecule biosynthetic process (GO:0010556) 1.433ALX1, ALX4, ALX3
biological regulation (GO:0065007) 0.393ALX1, ALX4, ALX3
organic cyclic compound metabolic process (GO:1901360) 1.263ALX1, ALX4, ALX3
regulation of gene expression (GO:0010468) 1.373ALX1, ALX4, ALX3
heterocycle biosynthetic process (GO:0018130) 1.73ALX1, ALX4, ALX3
skeletal system morphogenesis (GO:0048705) 4.983ALX1, ALX4, ALX3
embryonic skeletal system morphogenesis (GO:0048704) 5.313ALX1, ALX4, ALX3
organ morphogenesis (GO:0009887) 3.553ALX1, ALX4, ALX3
multicellular organismal process (GO:0032501) 1.453ALX1, ALX4, ALX3
nucleobase-containing compound metabolic process (GO:0006139) 1.353ALX1, ALX4, ALX3
regulation of macromolecule metabolic process (GO:0060255) 1.083ALX1, ALX4, ALX3
cellular aromatic compound metabolic process (GO:0006725) 1.33ALX1, ALX4, ALX3
cellular process (GO:0009987) 0.263ALX1, ALX4, ALX3
regulation of biosynthetic process (GO:0009889) 1.373ALX1, ALX4, ALX3
regulation of nucleic acid-templated transcription (GO:1903506) 1.553ALX1, ALX4, ALX3
regulation of cellular process (GO:0050794) 0.53ALX1, ALX4, ALX3
single-organism developmental process (GO:0044767) 1.493ALX1, ALX4, ALX3
pattern specification process (GO:0007389) 3.793ALX1, ALX4, ALX3
biosynthetic process (GO:0009058) 1.323ALX1, ALX4, ALX3
macromolecule biosynthetic process (GO:0009059) 1.613ALX1, ALX4, ALX3
embryonic morphogenesis (GO:0048598) 3.723ALX1, ALX4, ALX3
regulation of nitrogen compound metabolic process (GO:0051171) 1.363ALX1, ALX4, ALX3
metabolic process (GO:0008152) 0.583ALX1, ALX4, ALX3
regulation of RNA biosynthetic process (GO:2001141) 1.553ALX1, ALX4, ALX3
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723ALX1, ALX4, ALX3
heterocycle metabolic process (GO:0046483) 1.313ALX1, ALX4, ALX3
RNA metabolic process (GO:0016070) 1.593ALX1, ALX4, ALX3
primary metabolic process (GO:0044238) 0.693ALX1, ALX4, ALX3
single-organism process (GO:0044699) 0.483ALX1, ALX4, ALX3
cellular nitrogen compound biosynthetic process (GO:0044271) 1.593ALX1, ALX4, ALX3
single-multicellular organism process (GO:0044707) 1.783ALX1, ALX4, ALX3
regulation of RNA metabolic process (GO:0051252) 1.523ALX1, ALX4, ALX3
anatomical structure development (GO:0048856) 1.583ALX1, ALX4, ALX3
cellular metabolic process (GO:0044237) 0.693ALX1, ALX4, ALX3
macromolecule metabolic process (GO:0043170) 0.833ALX1, ALX4, ALX3
regulation of transcription, DNA-templated (GO:0006355) 1.563ALX1, ALX4, ALX3
nitrogen compound metabolic process (GO:0006807) 1.133ALX1, ALX4, ALX3
transcription, DNA-templated (GO:0006351) 1.913ALX1, ALX4, ALX3
aromatic compound biosynthetic process (GO:0019438) 1.73ALX1, ALX4, ALX3
positive regulation of metabolic process (GO:0009893) 1.742ALX1, ALX4
positive regulation of biosynthetic process (GO:0009891) 2.292ALX1, ALX4
positive regulation of cellular metabolic process (GO:0031325) 1.812ALX1, ALX4
palate development (GO:0060021) 5.382ALX1, ALX4
positive regulation of gene expression (GO:0010628) 2.352ALX1, ALX4
regulation of cell death (GO:0010941) 2.432ALX4, ALX3
regulation of apoptotic process (GO:0042981) 2.52ALX4, ALX3
positive regulation of macromolecule metabolic process (GO:0010604) 1.812ALX1, ALX4
positive regulation of cellular biosynthetic process (GO:0031328) 2.32ALX1, ALX4
regulation of programmed cell death (GO:0043067) 2.492ALX4, ALX3
hindlimb morphogenesis (GO:0035137) 6.122ALX4, ALX3
transcription from RNA polymerase II promoter (GO:0006366) 3.382ALX1, ALX4
positive regulation of biological process (GO:0048518) 1.22ALX1, ALX4
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562ALX1, ALX4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352ALX1, ALX4
embryonic forelimb morphogenesis (GO:0035115) 6.262ALX4, ALX3
embryonic hindlimb morphogenesis (GO:0035116) 6.362ALX4, ALX3
forelimb morphogenesis (GO:0035136) 6.042ALX4, ALX3
regionalization (GO:0003002) 4.242ALX1, ALX4
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292ALX1, ALX4
anterior/posterior pattern specification (GO:0009952) 4.712ALX1, ALX4
positive regulation of RNA metabolic process (GO:0051254) 2.512ALX1, ALX4
positive regulation of RNA biosynthetic process (GO:1902680) 2.542ALX1, ALX4
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392ALX1, ALX4
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242ALX1, ALX4
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812ALX1, ALX4
positive regulation of cellular process (GO:0048522) 1.32ALX1, ALX4
positive regulation of transcription, DNA-templated (GO:0045893) 2.562ALX1, ALX4

NET-GE enrichment

Term New enriched termICP valueGenes
embryonic morphogenesis (GO:0048598) -3.720.001ALX1, ALX4, ALX3
embryonic skeletal system morphogenesis (GO:0048704) -5.310.001ALX1, ALX4, ALX3
organ morphogenesis (GO:0009887) -3.550.001ALX1, ALX4, ALX3
limb morphogenesis (GO:0035108) -5.050.0ALX1, ALX4, ALX3
brain development (GO:0007420) NEW4.240.013ALX1, ALX4, ALX3
embryonic limb morphogenesis (GO:0030326) -5.240.0ALX1, ALX4, ALX3
pattern specification process (GO:0007389) -3.790.001ALX1, ALX4, ALX3
appendage morphogenesis (GO:0035107) -5.050.0ALX1, ALX4, ALX3
skeletal system morphogenesis (GO:0048705) -4.980.0ALX1, ALX4, ALX3
palate development (GO:0060021) -5.380.008ALX1, ALX4
embryonic forelimb morphogenesis (GO:0035115) -6.260.01ALX4, ALX3
embryonic hindlimb morphogenesis (GO:0035116) -6.360.001ALX4, ALX3
embryonic organ morphogenesis (GO:0048562) -4.920.0ALX1, ALX4, ALX3
forelimb morphogenesis (GO:0035136) -6.040.002ALX4, ALX3
hindlimb morphogenesis (GO:0035137) -6.120.002ALX4, ALX3
embryonic appendage morphogenesis (GO:0035113) -5.240.0ALX1, ALX4, ALX3
anatomical structure morphogenesis (GO:0009653) -2.530.045ALX1, ALX4, ALX3
anterior/posterior pattern specification (GO:0009952) -4.710.026ALX1, ALX4
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.63ALX1, ALX4, ALX3
nucleus (GO:0005634) 1.073ALX1, ALX4, ALX3
cell part (GO:0044464) 0.113ALX1, ALX4, ALX3
intracellular organelle (GO:0043229) 0.513ALX1, ALX4, ALX3
intracellular part (GO:0044424) 0.283ALX1, ALX4, ALX3
membrane-bounded organelle (GO:0043227) 0.473ALX1, ALX4, ALX3
organelle (GO:0043226) 0.43ALX1, ALX4, ALX3
protein complex (GO:0043234) 1.512ALX1, ALX4
macromolecular complex (GO:0032991) 1.352ALX1, ALX4
transcription factor complex (GO:0005667) 4.12ALX1, ALX4

NET-GE enrichment

Term New enriched termICP valueGenes
transcription factor complex (GO:0005667) -4.10.006ALX1, ALX4