Disease table of ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD OMIM ID: PS206100

Gene-disease associations table

GeneAssociated with ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
STEAP3ClinVar, OMIMHGNC link2q14.21PS206100
SLC11A2ClinVar, OMIM, HUMSAVARHGNC link12q13.121PS206100

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
STEAP3SLC11A2No-1UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Iron uptake and transportR-HSA-9179377.562STEAP3, SLC11A2
Transmembrane transport of small moleculesR-HSA-3825513.792STEAP3, SLC11A2

NET-GE enrichment

Term New enriched termICP valueGenes
Transmembrane transport of small molecules (R-HSA-382551) -3.790.037STEAP3, SLC11A2
Iron uptake and transport (R-HSA-917937) -7.560.0STEAP3, SLC11A2
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cation binding (GO:0043169) 1.42STEAP3, SLC11A2
metal ion binding (GO:0046872) 1.412STEAP3, SLC11A2
binding (GO:0005488) 0.182STEAP3, SLC11A2
protein binding (GO:0005515) 0.462STEAP3, SLC11A2
ion binding (GO:0043167) 1.362STEAP3, SLC11A2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein localization (GO:0008104) 2.362STEAP3, SLC11A2
ion homeostasis (GO:0050801) 3.422STEAP3, SLC11A2
copper ion transport (GO:0006825) 6.732STEAP3, SLC11A2
homeostatic process (GO:0042592) 2.612STEAP3, SLC11A2
iron ion homeostasis (GO:0055072) 5.492STEAP3, SLC11A2
iron ion transport (GO:0006826) 5.72STEAP3, SLC11A2
transition metal ion homeostasis (GO:0055076) 5.092STEAP3, SLC11A2
inorganic ion homeostasis (GO:0098771) 3.432STEAP3, SLC11A2
regulation of cell death (GO:0010941) 2.432STEAP3, SLC11A2
regulation of apoptotic process (GO:0042981) 2.52STEAP3, SLC11A2
regulation of biological process (GO:0050789) 0.452STEAP3, SLC11A2
single-organism process (GO:0044699) 0.482STEAP3, SLC11A2
single-organism metabolic process (GO:0044710) 1.632STEAP3, SLC11A2
transition metal ion transport (GO:0000041) 5.052STEAP3, SLC11A2
regulation of programmed cell death (GO:0043067) 2.492STEAP3, SLC11A2
biological regulation (GO:0065007) 0.392STEAP3, SLC11A2
organic substance transport (GO:0071702) 2.152STEAP3, SLC11A2
regulation of biological quality (GO:0065008) 1.682STEAP3, SLC11A2
iron ion import (GO:0097286) 7.332STEAP3, SLC11A2
cellular process (GO:0009987) 0.262STEAP3, SLC11A2
cation transport (GO:0006812) 3.112STEAP3, SLC11A2
ion transport (GO:0006811) 2.662STEAP3, SLC11A2
transport (GO:0006810) 1.512STEAP3, SLC11A2
regulation of cellular process (GO:0050794) 0.52STEAP3, SLC11A2
establishment of protein localization (GO:0045184) 2.532STEAP3, SLC11A2
single-organism transport (GO:0044765) 2.182STEAP3, SLC11A2
metal ion transport (GO:0030001) 3.362STEAP3, SLC11A2
metabolic process (GO:0008152) 0.582STEAP3, SLC11A2
metal ion homeostasis (GO:0055065) 3.612STEAP3, SLC11A2
cation homeostasis (GO:0055080) 3.462STEAP3, SLC11A2
establishment of localization (GO:0051234) 1.482STEAP3, SLC11A2
localization (GO:0051179) 1.42STEAP3, SLC11A2
single-organism localization (GO:1902578) 2.092STEAP3, SLC11A2
macromolecule localization (GO:0033036) 2.342STEAP3, SLC11A2
trivalent inorganic cation transport (GO:0072512) 6.072STEAP3, SLC11A2
chemical homeostasis (GO:0048878) 2.972STEAP3, SLC11A2
ferric iron transport (GO:0015682) 6.072STEAP3, SLC11A2
transferrin transport (GO:0033572) 6.172STEAP3, SLC11A2
protein transport (GO:0015031) 2.622STEAP3, SLC11A2
single-organism cellular process (GO:0044763) 0.652STEAP3, SLC11A2

NET-GE enrichment

Term New enriched termICP valueGenes
cellular transition metal ion homeostasis (GO:0046916) NEW5.420.006STEAP3, SLC11A2
copper ion transport (GO:0006825) -6.730.0STEAP3, SLC11A2
transition metal ion transport (GO:0000041) -5.050.019STEAP3, SLC11A2
iron ion homeostasis (GO:0055072) -5.490.016STEAP3, SLC11A2
iron ion transport (GO:0006826) -5.70.002STEAP3, SLC11A2
transition metal ion homeostasis (GO:0055076) -5.090.01STEAP3, SLC11A2
cellular iron ion homeostasis (GO:0006879) NEW5.90.003STEAP3, SLC11A2
iron ion import (GO:0097286) -7.330.0STEAP3, SLC11A2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
late endosome (GO:0005770) 4.852STEAP3, SLC11A2
intracellular organelle (GO:0043229) 0.512STEAP3, SLC11A2
intrinsic component of plasma membrane (GO:0031226) 2.532STEAP3, SLC11A2
organelle (GO:0043226) 0.42STEAP3, SLC11A2
intrinsic component of membrane (GO:0031224) 1.132STEAP3, SLC11A2
endosome membrane (GO:0010008) 3.832STEAP3, SLC11A2
organelle membrane (GO:0031090) 1.972STEAP3, SLC11A2
vacuole (GO:0005773) 2.922STEAP3, SLC11A2
membrane-bounded organelle (GO:0043227) 0.472STEAP3, SLC11A2
integral component of membrane (GO:0016021) 1.142STEAP3, SLC11A2
membrane (GO:0016020) 0.682STEAP3, SLC11A2
vacuolar membrane (GO:0005774) 3.452STEAP3, SLC11A2
vacuolar part (GO:0044437) 3.262STEAP3, SLC11A2
plasma membrane part (GO:0044459) 1.952STEAP3, SLC11A2
bounding membrane of organelle (GO:0098588) 2.392STEAP3, SLC11A2
integral component of plasma membrane (GO:0005887) 2.572STEAP3, SLC11A2
intracellular membrane-bounded organelle (GO:0043231) 0.62STEAP3, SLC11A2
cell part (GO:0044464) 0.112STEAP3, SLC11A2
intracellular organelle part (GO:0044446) 0.812STEAP3, SLC11A2
cytoplasmic part (GO:0044444) 0.822STEAP3, SLC11A2
endosomal part (GO:0044440) 3.732STEAP3, SLC11A2
intracellular part (GO:0044424) 0.282STEAP3, SLC11A2
membrane part (GO:0044425) 0.952STEAP3, SLC11A2
endosome (GO:0005768) 3.252STEAP3, SLC11A2
whole membrane (GO:0098805) 2.852STEAP3, SLC11A2
organelle part (GO:0044422) 0.792STEAP3, SLC11A2

NET-GE enrichment

Term New enriched termICP valueGenes
late endosome (GO:0005770) -4.850.002STEAP3, SLC11A2
endosome (GO:0005768) -3.250.023STEAP3, SLC11A2
endosomal part (GO:0044440) -3.730.024STEAP3, SLC11A2
endosome membrane (GO:0010008) -3.830.022STEAP3, SLC11A2