Disease table of ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD OMIM ID: PS206100

Gene-disease associations table

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Gene	Associated with ANEMIA, HYPOCHROMIC MICROCYTIC, WITH IRON OVERLOAD in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
SLC11A2	ClinVar, OMIM, HUMSAVAR	HGNC link	12q13.12	1	PS206100
STEAP3	ClinVar, OMIM	HGNC link	2q14.2	1	PS206100

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Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

Interactions from BIOGRID - physical

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
STEAP3	SLC11A2	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

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REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Iron uptake and transport	R-HSA-917937	7.56	2	STEAP3, SLC11A2
Transmembrane transport of small molecules	R-HSA-382551	3.79	2	STEAP3, SLC11A2

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
Iron uptake and transport (R-HSA-917937)	-	7.56	0.0	STEAP3, SLC11A2
Transmembrane transport of small molecules (R-HSA-382551)	-	3.79	0.037	STEAP3, SLC11A2

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GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

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GO	IC	Number of genes with the same GO	Genes
metal ion binding (GO:0046872)	1.41	2	STEAP3, SLC11A2
cation binding (GO:0043169)	1.4	2	STEAP3, SLC11A2
ion binding (GO:0043167)	1.36	2	STEAP3, SLC11A2
protein binding (GO:0005515)	0.46	2	STEAP3, SLC11A2
binding (GO:0005488)	0.18	2	STEAP3, SLC11A2

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GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
iron ion import (GO:0097286)	7.33	2	STEAP3, SLC11A2
copper ion transport (GO:0006825)	6.73	2	STEAP3, SLC11A2
transferrin transport (GO:0033572)	6.17	2	STEAP3, SLC11A2
trivalent inorganic cation transport (GO:0072512)	6.07	2	STEAP3, SLC11A2
ferric iron transport (GO:0015682)	6.07	2	STEAP3, SLC11A2
iron ion transport (GO:0006826)	5.7	2	STEAP3, SLC11A2
iron ion homeostasis (GO:0055072)	5.49	2	STEAP3, SLC11A2
transition metal ion homeostasis (GO:0055076)	5.09	2	STEAP3, SLC11A2
transition metal ion transport (GO:0000041)	5.05	2	STEAP3, SLC11A2
metal ion homeostasis (GO:0055065)	3.61	2	STEAP3, SLC11A2

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
iron ion import (GO:0097286)	-	7.33	0.0	STEAP3, SLC11A2
copper ion transport (GO:0006825)	-	6.73	0.0	STEAP3, SLC11A2
cellular iron ion homeostasis (GO:0006879)	NEW	5.9	0.003	STEAP3, SLC11A2
iron ion transport (GO:0006826)	-	5.7	0.002	STEAP3, SLC11A2
iron ion homeostasis (GO:0055072)	-	5.49	0.016	STEAP3, SLC11A2
cellular transition metal ion homeostasis (GO:0046916)	NEW	5.42	0.006	STEAP3, SLC11A2
transition metal ion homeostasis (GO:0055076)	-	5.09	0.01	STEAP3, SLC11A2
transition metal ion transport (GO:0000041)	-	5.05	0.019	STEAP3, SLC11A2

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GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

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GO	IC	Number of genes with the same GO	Genes
late endosome (GO:0005770)	4.85	2	STEAP3, SLC11A2
endosome membrane (GO:0010008)	3.83	2	STEAP3, SLC11A2
endosomal part (GO:0044440)	3.73	2	STEAP3, SLC11A2
vacuolar membrane (GO:0005774)	3.45	2	STEAP3, SLC11A2
vacuolar part (GO:0044437)	3.26	2	STEAP3, SLC11A2
endosome (GO:0005768)	3.25	2	STEAP3, SLC11A2
vacuole (GO:0005773)	2.92	2	STEAP3, SLC11A2
whole membrane (GO:0098805)	2.85	2	STEAP3, SLC11A2
integral component of plasma membrane (GO:0005887)	2.57	2	STEAP3, SLC11A2
intrinsic component of plasma membrane (GO:0031226)	2.53	2	STEAP3, SLC11A2

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NET-GE enrichment

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Term	New enriched term	IC	P value	Genes
late endosome (GO:0005770)	-	4.85	0.002	STEAP3, SLC11A2
endosome membrane (GO:0010008)	-	3.83	0.022	STEAP3, SLC11A2
endosomal part (GO:0044440)	-	3.73	0.024	STEAP3, SLC11A2
endosome (GO:0005768)	-	3.25	0.023	STEAP3, SLC11A2

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