Gene | Associated with METHYLCROTONYLGLYCINURIA in | Link to HGNC | Cytogenetic band | Number of associated diseases | Associated diseases |
---|---|---|---|---|---|
MCCC2 | ClinVar, OMIM, HUMSAVAR | HGNC link | 5q13.2 | 1 | PS210200 |
MCCC1 | ClinVar, OMIM, HUMSAVAR | HGNC link | 3q27.1 | 1 | PS210200 |
Download the disease annotation in CSV format
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
MCCC2 | MCCC1 | Yes | 8 | HSPB2, DYNC1H1, HUWE1, IFIT1, PTEN, NTRK1, LGALS3, ECH1 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Interaction mode | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|---|
MCCC2 | MCCC1 | Yes | binding | 2 | ACACA, ACACB |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct Interaction | Number of shared interactors | Shared genes in interaction |
---|---|---|---|---|
MCCC2 | MCCC1 | No | 1 | DYNC1H1 |
Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)
Gene1 | Gene2 | Direct interaction | More information |
---|---|---|---|
MCCC1 | MCCC2 | yes, complex | Probably they form a dodecamer composed of six biotin-containing alpha subunits (MCCC1) and six beta (MCCC2) subunits. [UniProt] |
KEGG term | KEGG term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
Valine, leucine and isoleucine degradation | hsa00280 | 7.09 | 2 | MCCC2, MCCC1 |
Metabolic pathways | hsa01100 | 2.49 | 2 | MCCC2, MCCC1 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
Valine, leucine and isoleucine degradation (hsa00280) | - | 7.09 | 0.0 | MCCC2, MCCC1 |
Amino acid metabolism | NEW | 4.63 | 0.033 | MCCC2, MCCC1 |
REACTOME term | REACTOME term ID | IC | Number of genes with the same term | Genes |
---|---|---|---|---|
Defects in biotin (Btn) metabolism | R-HSA-3323169 | 9.81 | 2 | MCCC2, MCCC1 |
Metabolism of water-soluble vitamins and cofactors | R-HSA-196849 | 6.54 | 2 | MCCC2, MCCC1 |
Metabolism of amino acids and derivatives | R-HSA-71291 | 5.4 | 2 | MCCC2, MCCC1 |
Branched-chain amino acid catabolism | R-HSA-70895 | 8.89 | 2 | MCCC2, MCCC1 |
Diseases of metabolism | R-HSA-5668914 | 6.57 | 2 | MCCC2, MCCC1 |
Defective HLCS causes multiple carboxylase deficiency | R-HSA-3371599 | 9.98 | 2 | MCCC2, MCCC1 |
Metabolism | R-HSA-1430728 | 2.34 | 2 | MCCC2, MCCC1 |
Metabolism of vitamins and cofactors | R-HSA-196854 | 6.54 | 2 | MCCC2, MCCC1 |
Defects in vitamin and cofactor metabolism | R-HSA-3296482 | 8.52 | 2 | MCCC2, MCCC1 |
Disease | R-HSA-1643685 | 3.33 | 2 | MCCC2, MCCC1 |
Biotin transport and metabolism | R-HSA-196780 | 9.52 | 2 | MCCC2, MCCC1 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
Defects in biotin (Btn) metabolism (R-HSA-3323169) | - | 9.81 | 0.0 | MCCC2, MCCC1 |
Defects in vitamin and cofactor metabolism (R-HSA-3296482) | - | 8.52 | 0.0 | MCCC2, MCCC1 |
Biotin transport and metabolism (R-HSA-196780) | - | 9.52 | 0.0 | MCCC2, MCCC1 |
Branched-chain amino acid catabolism (R-HSA-70895) | - | 8.89 | 0.0 | MCCC2, MCCC1 |
Diseases of metabolism (R-HSA-5668914) | - | 6.57 | 0.004 | MCCC2, MCCC1 |
Defective HLCS causes multiple carboxylase deficiency (R-HSA-3371599) | - | 9.98 | 0.0 | MCCC2, MCCC1 |
Metabolism of amino acids and derivatives (R-HSA-71291) | - | 5.4 | 0.019 | MCCC2, MCCC1 |
Metabolism of water-soluble vitamins and cofactors (R-HSA-196849) | - | 6.54 | 0.003 | MCCC2, MCCC1 |
Metabolism of vitamins and cofactors (R-HSA-196854) | - | 6.54 | 0.003 | MCCC2, MCCC1 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
methylcrotonoyl-CoA carboxylase activity (GO:0004485) | - | 9.05 | 0.0 | MCCC2, MCCC1 |
CoA carboxylase activity (GO:0016421) | - | 7.95 | 0.0 | MCCC2, MCCC1 |
ligase activity, forming carbon-carbon bonds (GO:0016885) | - | 7.79 | 0.0 | MCCC2, MCCC1 |
ligase activity (GO:0016874) | - | 3.72 | 0.025 | MCCC2, MCCC1 |
Term | New enriched term | IC | P value | Genes |
---|---|---|---|---|
mitochondrial matrix (GO:0005759) | - | 4.03 | 0.004 | MCCC2, MCCC1 |
intracellular organelle lumen (GO:0070013) | - | 3.05 | 0.02 | MCCC2, MCCC1 |
mitochondrial part (GO:0044429) | - | 2.92 | 0.042 | MCCC2, MCCC1 |
membrane-enclosed lumen (GO:0031974) | - | 3.05 | 0.029 | MCCC2, MCCC1 |
organelle lumen (GO:0043233) | - | 3.05 | 0.024 | MCCC2, MCCC1 |