Gene table of NTRK1 : neurotrophic receptor tyrosine kinase 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with NTRK1	OMIM link	Number of associated genes	genes
PS162400	HEREDITARY SENSORY AND AUTONOMIC NEUROPATHY	ClinVar, OMIM, HUMSAVAR	link to OMIM	14	DST, WNK1, NTRK1, PRDM12, DNMT1, IKBKAP, FAM134B, NGF, ATL1, KIF1A, SCN11A, ATL3, SPTLC2, SPTLC1
155240	THYROID CARCINOMA, FAMILIAL MEDULLARY	ClinVar, OMIM	link to OMIM	2	NTRK1, RET

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Annotation of the gene NTRK1

Associated genes in ENSEMBL

ENSG00000198400

Associated proteins - SwissProt Accession ID

P04629

Associated PDB IDs

Cytogenetic Band

1q23.1

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Thyroid cancer	hsa05216	7.48
Pathways in cancer	hsa05200	3.98
Transcriptional misregulation in cancer	hsa05202	5.21
Neurotrophin signaling pathway	hsa04722	5.78
Inflammatory mediator regulation of TRP channels	hsa04750	6.07
Endocytosis	hsa04144	4.92
Central carbon metabolism in cancer	hsa05230	6.7
MAPK signaling pathway	hsa04010	4.63
Apoptosis	hsa04210	6.23

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Prolonged ERK activation events	R-HSA-169893	5.11
Signalling to STAT3	R-HSA-198745	11.4
PI3K/AKT activation	R-HSA-198203	6.32
Signalling by NGF	R-HSA-166520	4.23
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12
Frs2-mediated activation	R-HSA-170968	5.12
TRKA activation by NGF	R-HSA-187042	11.98
ARMS-mediated activation	R-HSA-170984	5.12
Signalling to RAS	R-HSA-167044	5.08
Signal Transduction	R-HSA-162582	1.78
Signalling to ERKs	R-HSA-187687	5.04
NGF-independant TRKA activation	R-HSA-187024	10.66
Activation of TRKA receptors	R-HSA-187015	10.4
Retrograde neurotrophin signalling	R-HSA-177504	9.28
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
PLC-gamma1 signalling	R-HSA-167021	7.89

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
signaling receptor activity	GO:0038023	2.49
ribonucleotide binding	GO:0032553	2.19
purine ribonucleoside triphosphate binding	GO:0035639	2.22
neurotrophin p75 receptor binding	GO:0005166	8.35
enzyme binding	GO:0019899	2.27
neurotrophin receptor binding	GO:0005165	7.17
molecular transducer activity	GO:0060089	2.32
growth factor binding	GO:0019838	4.89
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
ATP binding	GO:0005524	2.43
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
nerve growth factor receptor activity	GO:0010465	9.05
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
transmembrane signaling receptor activity	GO:0004888	2.57
nucleotide binding	GO:0000166	1.96
purine ribonucleotide binding	GO:0032555	2.2
transferase activity	GO:0016740	1.95
neurotrophin receptor activity	GO:0005030	8.35
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
neurotrophin binding	GO:0043121	7.44
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
small molecule binding	GO:0036094	1.89
kinase binding	GO:0019900	3.32
receptor binding	GO:0005102	2.43
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
catalytic activity	GO:0003824	1.05
ribonucleoside binding	GO:0032549	2.22
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
ephrin receptor activity	GO:0005003	6.79
adenyl ribonucleotide binding	GO:0032559	2.41
GPI-linked ephrin receptor activity	GO:0005004	7.79
protein binding	GO:0005515	0.46
organic cyclic compound binding	GO:0097159	1.05
nerve growth factor binding	GO:0048406	7.95
protein dimerization activity	GO:0046983	2.72
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
transmembrane receptor activity	GO:0099600	2.53
receptor activity	GO:0004872	2.32