Disease table of ASPERGER SYNDROME, SUSCEPTIBILITY TO OMIM ID: PS608638

Gene-disease associations table

GeneAssociated with ASPERGER SYNDROME, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
NLGN4XOMIMHGNC linkXp22.312PS209850, PS608638
NLGN3ClinVar, OMIM, HUMSAVARHGNC linkXq13.12PS209850, PS608638

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
X2NLGN3, NLGN4X
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NLGN4XNLGN3No1DLG4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
NLGN4XNLGN3No-1DLG4

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
NLGN3NLGN4Xyes, indirectThey interact in a indrect manner because they both interact with NRXN1. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Cell adhesion molecules (CAMs)hsa045145.362NLGN4X, NLGN3

NET-GE enrichment

Term New enriched termICP valueGenes
Cell adhesion molecules (CAMs) (hsa04514) -5.360.017NLGN4X, NLGN3
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
hydrolase activity (GO:0016787) 1.92NLGN4X, NLGN3
neurexin family protein binding (GO:0042043) 7.12NLGN4X, NLGN3
molecular transducer activity (GO:0060089) 2.322NLGN4X, NLGN3
hydrolase activity, acting on ester bonds (GO:0016788) 3.12NLGN4X, NLGN3
catalytic activity (GO:0003824) 1.052NLGN4X, NLGN3
scaffold protein binding (GO:0097110) 5.932NLGN4X, NLGN3
carboxylic ester hydrolase activity (GO:0052689) 4.812NLGN4X, NLGN3
protein binding (GO:0005515) 0.462NLGN4X, NLGN3
receptor activity (GO:0004872) 2.322NLGN4X, NLGN3
receptor binding (GO:0005102) 2.432NLGN4X, NLGN3
cell adhesion molecule binding (GO:0050839) 4.52NLGN4X, NLGN3
binding (GO:0005488) 0.182NLGN4X, NLGN3

NET-GE enrichment

Term New enriched termICP valueGenes
neurexin family protein binding (GO:0042043) -7.10.0NLGN4X, NLGN3
cell adhesion molecule binding (GO:0050839) -4.50.022NLGN4X, NLGN3
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of membrane potential (GO:0042391) 3.892NLGN4X, NLGN3
cellular component assembly (GO:0022607) 2.142NLGN4X, NLGN3
single organismal cell-cell adhesion (GO:0016337) 3.692NLGN4X, NLGN3
developmental growth (GO:0048589) 4.052NLGN4X, NLGN3
presynaptic membrane organization (GO:0097090) 7.432NLGN4X, NLGN3
negative regulation of response to stimulus (GO:0048585) 2.522NLGN4X, NLGN3
cell differentiation (GO:0030154) 2.142NLGN4X, NLGN3
regulation of response to stimulus (GO:0048583) 1.542NLGN4X, NLGN3
behavior (GO:0007610) 3.472NLGN4X, NLGN3
learning or memory (GO:0007611) 4.332NLGN4X, NLGN3
membrane organization (GO:0061024) 3.042NLGN4X, NLGN3
synapse organization (GO:0050808) 4.872NLGN4X, NLGN3
cellular component organization (GO:0016043) 1.242NLGN4X, NLGN3
regulation of signaling (GO:0023051) 1.722NLGN4X, NLGN3
regulation of cell communication (GO:0010646) 1.732NLGN4X, NLGN3
regulation of biological process (GO:0050789) 0.452NLGN4X, NLGN3
cellular component organization or biogenesis (GO:0071840) 1.222NLGN4X, NLGN3
growth (GO:0040007) 3.82NLGN4X, NLGN3
negative regulation of signal transduction (GO:0009968) 2.752NLGN4X, NLGN3
regulation of signal transduction (GO:0009966) 1.842NLGN4X, NLGN3
cellular developmental process (GO:0048869) 1.822NLGN4X, NLGN3
cell adhesion (GO:0007155) 2.822NLGN4X, NLGN3
presynaptic membrane assembly (GO:0097105) 7.532NLGN4X, NLGN3
cell-cell adhesion (GO:0098609) 3.342NLGN4X, NLGN3
biological regulation (GO:0065007) 0.392NLGN4X, NLGN3
single-organism process (GO:0044699) 0.482NLGN4X, NLGN3
neurological system process (GO:0050877) 2.642NLGN4X, NLGN3
negative regulation of biological process (GO:0048519) 1.332NLGN4X, NLGN3
system process (GO:0003008) 2.32NLGN4X, NLGN3
membrane assembly (GO:0071709) 6.592NLGN4X, NLGN3
vocalization behavior (GO:0071625) 7.092NLGN4X, NLGN3
developmental process (GO:0032502) 1.362NLGN4X, NLGN3
single organism cell adhesion (GO:0098602) 3.632NLGN4X, NLGN3
social behavior (GO:0035176) 5.92NLGN4X, NLGN3
learning (GO:0007612) 4.852NLGN4X, NLGN3
multicellular organismal process (GO:0032501) 1.452NLGN4X, NLGN3
cellular process (GO:0009987) 0.262NLGN4X, NLGN3
regulation of cellular process (GO:0050794) 0.52NLGN4X, NLGN3
single-organism developmental process (GO:0044767) 1.492NLGN4X, NLGN3
single-organism membrane organization (GO:0044802) 3.192NLGN4X, NLGN3
neuron cell-cell adhesion (GO:0007158) 6.962NLGN4X, NLGN3
intraspecies interaction between organisms (GO:0051703) 5.92NLGN4X, NLGN3
modulation of synaptic transmission (GO:0050804) 4.092NLGN4X, NLGN3
multi-organism behavior (GO:0051705) 5.62NLGN4X, NLGN3
multi-organism process (GO:0051704) 2.652NLGN4X, NLGN3
adult behavior (GO:0030534) 4.792NLGN4X, NLGN3
negative regulation of synaptic transmission (GO:0050805) 5.672NLGN4X, NLGN3
regulation of biological quality (GO:0065008) 1.682NLGN4X, NLGN3
biological adhesion (GO:0022610) 2.812NLGN4X, NLGN3
single-multicellular organism process (GO:0044707) 1.782NLGN4X, NLGN3
negative regulation of signaling (GO:0023057) 2.652NLGN4X, NLGN3
single-organism behavior (GO:0044708) 3.792NLGN4X, NLGN3
negative regulation of excitatory postsynaptic potential (GO:0090394) 7.532NLGN4X, NLGN3
cognition (GO:0050890) 4.22NLGN4X, NLGN3
modulation of excitatory postsynaptic potential (GO:0098815) 6.332NLGN4X, NLGN3
single-organism cellular process (GO:0044763) 0.652NLGN4X, NLGN3
negative regulation of cellular process (GO:0048523) 1.412NLGN4X, NLGN3
negative regulation of cell communication (GO:0010648) 2.662NLGN4X, NLGN3

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of membrane potential (GO:0042391) -3.890.029NLGN4X, NLGN3
synapse organization (GO:0050808) -4.870.006NLGN4X, NLGN3
single organismal cell-cell adhesion (GO:0016337) -3.690.03NLGN4X, NLGN3
presynaptic membrane organization (GO:0097090) -7.430.0NLGN4X, NLGN3
learning (GO:0007612) -4.850.006NLGN4X, NLGN3
learning or memory (GO:0007611) -4.330.017NLGN4X, NLGN3
regulation of excitatory postsynaptic membrane potential (GO:0060079) NEW6.430.001NLGN4X, NLGN3
membrane depolarization (GO:0051899) NEW5.620.005NLGN4X, NLGN3
growth (GO:0040007) -3.80.046NLGN4X, NLGN3
presynaptic membrane assembly (GO:0097105) -7.530.0NLGN4X, NLGN3
membrane assembly (GO:0071709) -6.590.0NLGN4X, NLGN3
vocalization behavior (GO:0071625) -7.090.0NLGN4X, NLGN3
single organism cell adhesion (GO:0098602) -3.630.036NLGN4X, NLGN3
social behavior (GO:0035176) -5.90.006NLGN4X, NLGN3
neuron cell-cell adhesion (GO:0007158) -6.960.0NLGN4X, NLGN3
intraspecies interaction between organisms (GO:0051703) -5.90.006NLGN4X, NLGN3
regulation of postsynaptic membrane potential (GO:0060078) NEW5.720.002NLGN4X, NLGN3
multi-organism behavior (GO:0051705) -5.60.003NLGN4X, NLGN3
adult behavior (GO:0030534) -4.790.008NLGN4X, NLGN3
cognition (GO:0050890) -4.20.023NLGN4X, NLGN3
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
plasma membrane (GO:0005886) 1.392NLGN4X, NLGN3
dendrite (GO:0030425) 3.922NLGN4X, NLGN3
intracellular organelle (GO:0043229) 0.512NLGN4X, NLGN3
synapse (GO:0045202) 3.582NLGN4X, NLGN3
intrinsic component of plasma membrane (GO:0031226) 2.532NLGN4X, NLGN3
organelle (GO:0043226) 0.42NLGN4X, NLGN3
intrinsic component of membrane (GO:0031224) 1.132NLGN4X, NLGN3
extracellular space (GO:0005615) 2.632NLGN4X, NLGN3
integral component of membrane (GO:0016021) 1.142NLGN4X, NLGN3
membrane (GO:0016020) 0.682NLGN4X, NLGN3
neuron part (GO:0097458) 2.642NLGN4X, NLGN3
synapse part (GO:0044456) 3.422NLGN4X, NLGN3
cell junction (GO:0030054) 2.752NLGN4X, NLGN3
neuron projection (GO:0043005) 3.122NLGN4X, NLGN3
plasma membrane part (GO:0044459) 1.952NLGN4X, NLGN3
cell surface (GO:0009986) 3.442NLGN4X, NLGN3
integral component of plasma membrane (GO:0005887) 2.572NLGN4X, NLGN3
excitatory synapse (GO:0060076) 6.622NLGN4X, NLGN3
cell projection (GO:0042995) 2.472NLGN4X, NLGN3
cell part (GO:0044464) 0.112NLGN4X, NLGN3
intracellular part (GO:0044424) 0.282NLGN4X, NLGN3
membrane part (GO:0044425) 0.952NLGN4X, NLGN3
extracellular region part (GO:0044421) 1.572NLGN4X, NLGN3

NET-GE enrichment

Term New enriched termICP valueGenes
cell surface (GO:0009986) -3.440.024NLGN4X, NLGN3
synapse (GO:0045202) -3.580.005NLGN4X, NLGN3
excitatory synapse (GO:0060076) -6.620.0NLGN4X, NLGN3