Disease table of AUTISM, SUSCEPTIBLITY TO OMIM ID: PS209850

Gene-disease associations table

GeneAssociated with AUTISM, SUSCEPTIBLITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
NLGN3ClinVar, OMIM, HUMSAVARHGNC linkXq13.12PS209850, PS608638
CHD8ClinVar, OMIMHGNC link14q11.21PS209850
MECP2ClinVar, OMIMHGNC linkXq286300673, PS309510, PS209850, 312750, 143465, 105830
NLGN4XOMIMHGNC linkXp22.312PS209850, PS608638
SLC9A9ClinVar, OMIMHGNC link3q241PS209850
METClinVarHGNC link7q31.26114550, 607278, PS209850, 605074, PS220290, 142340
EN2ClinVarHGNC link7q36.31PS209850
CNTNAP2ClinVar, OMIMHGNC link7q352PS209850, 610042
RPL10ClinVar, OMIM, HUMSAVARHGNC linkXq281PS209850
PTCHD1OMIMHGNC linkXp22.111PS209850
EIF4EOMIMHGNC link4q231PS209850
SHANK2ClinVar, OMIMHGNC link11q13.41PS209850
TMLHEClinVar, OMIMHGNC linkXq281PS209850

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
Xq283RPL10, TMLHE, MECP2
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
Xq283RPL10, TMLHE, MECP2
Xp222PTCHD1, NLGN4X
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
7q33EN2, CNTNAP2, MET
Xp22PTCHD1, NLGN4X
Xq23RPL10, TMLHE, MECP2
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
7q3EN2, CNTNAP2, MET
Xp2PTCHD1, NLGN4X
Xq4RPL10, NLGN3, MECP2, TMLHE
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
73EN2, CNTNAP2, MET
X6NLGN4X, NLGN3, PTCHD1, TMLHE, MECP2, RPL10
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
CHD8YES1HOXA20
MECP2YES7CCND1, ALOX5, IGFBP3, TFF1, ESR1, GAD1, RELN0
FOXP2NO6SRPX2, SRPX, PLAUR, MET, NKX2-1, CNTNAP22MET, CNTNAP2
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CHD8YES1CTCF0
METYES13SP1, FOXP2, PAX3, SMAD7, TP53, SNAI2, HIF1A, MITF, SP3, YBX1, PAX5, PAX6, STAT10
CNTNAP2YES2FOXP2, TCF40
EIF4EYES1MYC0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NLGN3NLGN4XNo1DLG4
NLGN3CNTNAP2No1MEOX2
NLGN3SHANK2No1DLG4
CHD8MECP2No3TERF2, CREB1, SOX2
CHD8METNo1CTNNB1
CHD8RPL10No3NXF1, TOP3B, SIRT7
MECP2RPL10No2AP4S1, GTF2B
NLGN4XSHANK2No1DLG4
METRPL10No1SRC
METEIF4ENo1STUB1
RPL10EIF4ENo5NTRK1, EIF3F, EIF3A, ITGA4, PABPC1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
NLGN3NLGN4XNo-1DLG4
NLGN3SHANK2No-1DLG4
CHD8METNo-3UBC, AR, CTNNB1
CHD8EIF4ENo-2MAX, UBC
NLGN4XSHANK2No-1DLG4
METEIF4ENo-6FGF13, INS, EGFR, UBC, VEGFA, FGF2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
NLGN3NLGN4Xyes, indirectThey interact in a indrect manner because they both interact with NRXN1. [UniProt]
KEGG pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Cell adhesion molecules (CAMs)hsa045145.363CNTNAP2, NLGN4X, NLGN3
PI3K-Akt signaling pathwayhsa041514.212MET, EIF4E
REACTOME pathways annotation: shared terms (no NET-GE enrichment)

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Gene ExpressionR-HSA-741602.722RPL10, EIF4E
Metabolism of proteinsR-HSA-3924993.412RPL10, EIF4E
TranslationR-HSA-727665.82RPL10, EIF4E
L13a-mediated translational silencing of Ceruloplasmin expressionR-HSA-1568276.282RPL10, EIF4E
Cap-dependent Translation InitiationR-HSA-727376.182RPL10, EIF4E
Signal TransductionR-HSA-1625821.782CHD8, EIF4E
GTP hydrolysis and joining of the 60S ribosomal subunitR-HSA-727066.272RPL10, EIF4E
Eukaryotic Translation InitiationR-HSA-726136.182RPL10, EIF4E
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1812CHD8, TMLHE, SLC9A9, SHANK2, MET, NLGN4X, MECP2, EN2, NLGN3, RPL10, EIF4E, CNTNAP2
protein binding (GO:0005515) 0.4610CHD8, SLC9A9, SHANK2, MET, NLGN4X, MECP2, NLGN3, RPL10, EIF4E, CNTNAP2
organic cyclic compound binding (GO:0097159) 1.056CHD8, MET, RPL10, EN2, MECP2, EIF4E
heterocyclic compound binding (GO:1901363) 1.066CHD8, MET, RPL10, EN2, MECP2, EIF4E
catalytic activity (GO:0003824) 1.055MET, NLGN3, NLGN4X, TMLHE, CHD8
nucleic acid binding (GO:0003676) 1.445MECP2, CHD8, RPL10, EN2, EIF4E
small molecule binding (GO:0036094) 1.894MET, CHD8, TMLHE, MECP2
enzyme binding (GO:0019899) 2.274MET, CNTNAP2, MECP2, EIF4E
hydrolase activity (GO:0016787) 1.93CHD8, NLGN3, NLGN4X
poly(A) RNA binding (GO:0044822) 2.693RPL10, MECP2, EIF4E
nucleotide binding (GO:0000166) 1.963MET, CHD8, MECP2
molecular transducer activity (GO:0060089) 2.323MET, NLGN4X, NLGN3
protein domain specific binding (GO:0019904) 3.323CHD8, SHANK2, MECP2
DNA binding (GO:0003677) 1.923CHD8, EN2, MECP2
receptor activity (GO:0004872) 2.323MET, NLGN4X, NLGN3
receptor binding (GO:0005102) 2.433NLGN4X, NLGN3, SHANK2
nucleoside phosphate binding (GO:1901265) 1.963MET, CHD8, MECP2
RNA binding (GO:0003723) 2.363RPL10, MECP2, EIF4E
purine ribonucleoside triphosphate binding (GO:0035639) 2.222MET, CHD8
macromolecular complex binding (GO:0044877) 2.612CHD8, MECP2
structural molecule activity (GO:0005198) 3.12SHANK2, RPL10
purine nucleoside binding (GO:0001883) 2.222MET, CHD8
nucleoside binding (GO:0001882) 2.212MET, CHD8
anion binding (GO:0043168) 4.172NLGN4X, TMLHE
sequence-specific DNA binding (GO:0043565) 2.792EN2, MECP2
ion binding (GO:0043167) 1.362NLGN4X, TMLHE
ribonucleoside binding (GO:0032549) 2.222MET, CHD8
purine nucleotide binding (GO:0017076) 2.192MET, CHD8
ATP binding (GO:0005524) 2.432MET, CHD8
neurexin family protein binding (GO:0042043) 7.12NLGN4X, NLGN3
transcription factor binding (GO:0008134) 3.462MECP2, EIF4E
carboxylic ester hydrolase activity (GO:0052689) 4.812NLGN4X, NLGN3
hydrolase activity, acting on ester bonds (GO:0016788) 3.12NLGN4X, NLGN3
cell adhesion molecule binding (GO:0050839) 4.52NLGN4X, NLGN3
adenyl nucleotide binding (GO:0030554) 2.42MET, CHD8
carbohydrate derivative binding (GO:0097367) 2.032MET, CHD8
scaffold protein binding (GO:0097110) 5.932NLGN4X, NLGN3
adenyl ribonucleotide binding (GO:0032559) 2.412MET, CHD8
purine ribonucleotide binding (GO:0032555) 2.22MET, CHD8
chromatin binding (GO:0003682) 3.642CHD8, MECP2
purine ribonucleoside binding (GO:0032550) 2.222MET, CHD8
ribonucleotide binding (GO:0032553) 2.192MET, CHD8

NET-GE enrichment

Term New enriched termICP valueGenes
neurexin family protein binding (GO:0042043) -7.10.004NLGN4X, NLGN3
receptor activity (GO:0004872) -2.320.024CHD8, SHANK2, MET, PTCHD1, NLGN4X, RPL10, NLGN3, MECP2, EIF4E
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism process (GO:0044699) 0.4812CHD8, TMLHE, SLC9A9, SHANK2, MET, NLGN4X, MECP2, EN2, NLGN3, RPL10, EIF4E, CNTNAP2
cellular process (GO:0009987) 0.2611CHD8, TMLHE, SHANK2, MET, NLGN4X, MECP2, EN2, NLGN3, RPL10, EIF4E, CNTNAP2
biological regulation (GO:0065007) 0.3911CHD8, TMLHE, SLC9A9, MET, PTCHD1, NLGN4X, MECP2, EN2, NLGN3, SHANK2, EIF4E
multicellular organismal process (GO:0032501) 1.4510CHD8, MET, PTCHD1, NLGN4X, MECP2, EN2, NLGN3, SHANK2, EIF4E, CNTNAP2
regulation of biological process (GO:0050789) 0.4510CHD8, TMLHE, MET, PTCHD1, NLGN4X, MECP2, EN2, NLGN3, SHANK2, EIF4E
negative regulation of biological process (GO:0048519) 1.339CHD8, TMLHE, MET, NLGN4X, MECP2, EN2, NLGN3, SHANK2, EIF4E
single-multicellular organism process (GO:0044707) 1.789CHD8, MET, NLGN4X, MECP2, EN2, NLGN3, SHANK2, EIF4E, CNTNAP2
regulation of cellular process (GO:0050794) 0.59CHD8, MET, PTCHD1, NLGN4X, MECP2, EN2, NLGN3, SHANK2, EIF4E
developmental process (GO:0032502) 1.368CHD8, MET, NLGN4X, MECP2, EN2, NLGN3, EIF4E, CNTNAP2
cellular component organization (GO:0016043) 1.248CHD8, SHANK2, MET, NLGN4X, MECP2, NLGN3, RPL10, CNTNAP2
single-organism developmental process (GO:0044767) 1.498CHD8, MET, NLGN4X, MECP2, EN2, NLGN3, EIF4E, CNTNAP2
single-organism cellular process (GO:0044763) 0.658NLGN4X, SHANK2, MET, MECP2, EN2, NLGN3, RPL10, CNTNAP2
negative regulation of cellular process (GO:0048523) 1.418CHD8, MET, NLGN4X, MECP2, EN2, NLGN3, SHANK2, EIF4E
cellular component organization or biogenesis (GO:0071840) 1.228CHD8, SHANK2, MET, NLGN4X, MECP2, NLGN3, RPL10, CNTNAP2
positive regulation of biological process (GO:0048518) 1.27CHD8, MET, MECP2, EN2, NLGN3, SHANK2, EIF4E
positive regulation of cellular process (GO:0048522) 1.37CHD8, MET, MECP2, EN2, NLGN3, SHANK2, EIF4E
regulation of metabolic process (GO:0019222) 1.026CHD8, TMLHE, MET, MECP2, EN2, EIF4E
neurological system process (GO:0050877) 2.646NLGN4X, PTCHD1, MECP2, NLGN3, SHANK2, CNTNAP2
anatomical structure development (GO:0048856) 1.586CHD8, NLGN4X, MECP2, EN2, EIF4E, CNTNAP2
cognition (GO:0050890) 4.26NLGN4X, PTCHD1, MECP2, NLGN3, SHANK2, CNTNAP2
behavior (GO:0007610) 3.476NLGN4X, MECP2, NLGN3, SHANK2, EIF4E, CNTNAP2
organic substance metabolic process (GO:0071704) 0.636CHD8, TMLHE, MET, RPL10, MECP2, EIF4E
cellular metabolic process (GO:0044237) 0.696CHD8, TMLHE, MET, RPL10, MECP2, EIF4E
metabolic process (GO:0008152) 0.586CHD8, TMLHE, MET, RPL10, MECP2, EIF4E
single-organism behavior (GO:0044708) 3.796NLGN4X, MECP2, NLGN3, SHANK2, EIF4E, CNTNAP2
system process (GO:0003008) 2.36NLGN4X, PTCHD1, MECP2, NLGN3, SHANK2, CNTNAP2
localization (GO:0051179) 1.46SLC9A9, RPL10, NLGN3, MECP2, EIF4E, CNTNAP2
multi-organism process (GO:0051704) 2.656NLGN4X, MECP2, NLGN3, SHANK2, EIF4E, CNTNAP2
cellular component assembly (GO:0022607) 2.145NLGN4X, NLGN3, RPL10, MECP2, SHANK2
regulation of primary metabolic process (GO:0080090) 1.085MET, MECP2, CHD8, EN2, EIF4E
regulation of cellular biosynthetic process (GO:0031326) 1.385MET, EN2, MECP2, EIF4E, CHD8
learning (GO:0007612) 4.855CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
learning or memory (GO:0007611) 4.335CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
cellular biosynthetic process (GO:0044249) 1.375CHD8, RPL10, TMLHE, MECP2, EIF4E
cellular nitrogen compound metabolic process (GO:0034641) 1.225CHD8, RPL10, TMLHE, MECP2, EIF4E
nitrogen compound metabolic process (GO:0006807) 1.135CHD8, RPL10, TMLHE, MECP2, EIF4E
regulation of signaling (GO:0023051) 1.725CHD8, NLGN3, NLGN4X, MECP2, SHANK2
regulation of cell communication (GO:0010646) 1.735CHD8, NLGN3, NLGN4X, MECP2, SHANK2
organic substance biosynthetic process (GO:1901576) 1.345CHD8, RPL10, TMLHE, MECP2, EIF4E
cellular macromolecule metabolic process (GO:0044260) 0.935MET, CHD8, RPL10, MECP2, EIF4E
cellular developmental process (GO:0048869) 1.825MET, EN2, NLGN3, NLGN4X, MECP2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465MET, EN2, MECP2, EIF4E, CHD8
regulation of macromolecule metabolic process (GO:0060255) 1.085MET, EN2, MECP2, EIF4E, CHD8
animal organ development (GO:0048513) 2.535CNTNAP2, CHD8, EN2, MECP2, EIF4E
regulation of biological quality (GO:0065008) 1.685NLGN4X, NLGN3, SHANK2, MECP2, SLC9A9
regulation of gene expression (GO:0010468) 1.375EN2, MET, CHD8, MECP2, EIF4E
primary metabolic process (GO:0044238) 0.695MET, CHD8, RPL10, MECP2, EIF4E
social behavior (GO:0035176) 5.95CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
regulation of cellular metabolic process (GO:0031323) 1.075MET, EN2, MECP2, EIF4E, CHD8
transport (GO:0006810) 1.515RPL10, NLGN3, MECP2, EIF4E, SLC9A9
regulation of biosynthetic process (GO:0009889) 1.375EN2, MET, CHD8, MECP2, EIF4E
biosynthetic process (GO:0009058) 1.325CHD8, RPL10, TMLHE, MECP2, EIF4E
regulation of nitrogen compound metabolic process (GO:0051171) 1.365MET, EN2, MECP2, EIF4E, CHD8
intraspecies interaction between organisms (GO:0051703) 5.95CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
establishment of localization (GO:0051234) 1.485RPL10, NLGN3, MECP2, EIF4E, SLC9A9
multi-organism behavior (GO:0051705) 5.65CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
adult behavior (GO:0030534) 4.795CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
cellular nitrogen compound biosynthetic process (GO:0044271) 1.595CHD8, RPL10, TMLHE, MECP2, EIF4E
macromolecule metabolic process (GO:0043170) 0.835MET, CHD8, RPL10, MECP2, EIF4E
regulation of macromolecule biosynthetic process (GO:0010556) 1.435MET, EN2, MECP2, EIF4E, CHD8
synapse organization (GO:0050808) 4.874NLGN4X, NLGN3, SHANK2, MECP2
negative regulation of metabolic process (GO:0009892) 1.934CHD8, TMLHE, MECP2, EIF4E
positive regulation of metabolic process (GO:0009893) 1.744MET, CHD8, EN2, MECP2
positive regulation of biosynthetic process (GO:0009891) 2.294MET, CHD8, EN2, MECP2
negative regulation of response to stimulus (GO:0048585) 2.524MET, NLGN4X, NLGN3, CHD8
regulation of RNA biosynthetic process (GO:2001141) 1.554MET, EN2, CHD8, MECP2
regulation of response to stimulus (GO:0048583) 1.544MET, NLGN4X, NLGN3, CHD8
modulation of synaptic transmission (GO:0050804) 4.094NLGN4X, NLGN3, SHANK2, MECP2
nucleic acid metabolic process (GO:0090304) 1.464CHD8, RPL10, MECP2, EIF4E
negative regulation of signaling (GO:0023057) 2.654CHD8, NLGN3, NLGN4X, SHANK2
positive regulation of gene expression (GO:0010628) 2.354MET, EN2, CHD8, MECP2
negative regulation of cell communication (GO:0010648) 2.664CHD8, NLGN3, NLGN4X, SHANK2
cellular macromolecule biosynthetic process (GO:0034645) 1.664CHD8, RPL10, MECP2, EIF4E
regulation of cell death (GO:0010941) 2.434MET, CHD8, EN2, MECP2
organic cyclic compound metabolic process (GO:1901360) 1.264CHD8, RPL10, MECP2, EIF4E
cellular protein metabolic process (GO:0044267) 1.634MET, RPL10, MECP2, EIF4E
positive regulation of macromolecule metabolic process (GO:0010604) 1.814MET, CHD8, EN2, MECP2
positive regulation of cellular biosynthetic process (GO:0031328) 2.34MET, EN2, CHD8, MECP2
regulation of programmed cell death (GO:0043067) 2.494MET, EN2, CHD8, MECP2
negative regulation of programmed cell death (GO:0043069) 3.024MET, EN2, CHD8, MECP2
positive regulation of cellular metabolic process (GO:0031325) 1.814MET, CHD8, EN2, MECP2
vocalization behavior (GO:0071625) 7.094CNTNAP2, NLGN4X, NLGN3, SHANK2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.564MET, EN2, CHD8, MECP2
cell differentiation (GO:0030154) 2.144NLGN4X, NLGN3, EN2, MECP2
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.354MET, EN2, CHD8, MECP2
nucleobase-containing compound metabolic process (GO:0006139) 1.354CHD8, RPL10, MECP2, EIF4E
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434MET, CHD8, EN2, MECP2
negative regulation of cell death (GO:0060548) 2.954MET, EN2, CHD8, MECP2
cellular aromatic compound metabolic process (GO:0006725) 1.34CHD8, RPL10, MECP2, EIF4E
regulation of nucleic acid-templated transcription (GO:1903506) 1.554MET, EN2, CHD8, MECP2
macromolecule biosynthetic process (GO:0009059) 1.614CHD8, RPL10, MECP2, EIF4E
single-organism membrane organization (GO:0044802) 3.194CNTNAP2, NLGN4X, NLGN3, RPL10
positive regulation of transcription, DNA-templated (GO:0045893) 2.564MET, CHD8, EN2, MECP2
regulation of multicellular organismal process (GO:0051239) 1.874MET, NLGN3, MECP2, EIF4E
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.294MET, EN2, CHD8, MECP2
heterocycle metabolic process (GO:0046483) 1.314CHD8, RPL10, MECP2, EIF4E
RNA metabolic process (GO:0016070) 1.594CHD8, RPL10, MECP2, EIF4E
organonitrogen compound metabolic process (GO:1901564) 2.324RPL10, TMLHE, MECP2, EIF4E
membrane organization (GO:0061024) 3.044CNTNAP2, NLGN4X, NLGN3, RPL10
protein metabolic process (GO:0019538) 1.454MET, RPL10, MECP2, EIF4E
regulation of RNA metabolic process (GO:0051252) 1.524MET, CHD8, EN2, MECP2
positive regulation of RNA metabolic process (GO:0051254) 2.514MET, CHD8, EN2, MECP2
positive regulation of RNA biosynthetic process (GO:1902680) 2.544MET, EN2, CHD8, MECP2
regulation of transcription, DNA-templated (GO:0006355) 1.564MET, CHD8, EN2, MECP2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.394MET, EN2, CHD8, MECP2
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.244MET, EN2, CHD8, MECP2
regulation of membrane potential (GO:0042391) 3.893NLGN4X, NLGN3, MECP2
protein localization (GO:0008104) 2.363CNTNAP2, RPL10, MECP2
RNA biosynthetic process (GO:0032774) 1.843CHD8, RPL10, MECP2
negative regulation of biosynthetic process (GO:0009890) 2.473CHD8, MECP2, EIF4E
macromolecular complex subunit organization (GO:0043933) 2.143CHD8, RPL10, MECP2
negative regulation of cellular metabolic process (GO:0031324) 2.013CHD8, MECP2, EIF4E
positive regulation of synaptic transmission (GO:0050806) 5.073NLGN3, SHANK2, MECP2
negative regulation of synaptic transmission (GO:0050805) 5.673NLGN4X, NLGN3, SHANK2
positive regulation of signaling (GO:0023056) 2.413NLGN3, SHANK2, MECP2
cell adhesion (GO:0007155) 2.823CNTNAP2, NLGN4X, NLGN3
negative regulation of gene expression (GO:0010629) 2.483CHD8, MECP2, EIF4E
regulation of cell development (GO:0060284) 3.013NLGN3, MECP2, EIF4E
cell surface receptor signaling pathway (GO:0007166) 2.093MET, CHD8, PTCHD1
regulation of cell differentiation (GO:0045595) 2.423NLGN3, MECP2, EIF4E
positive regulation of cell communication (GO:0010647) 2.413NLGN3, SHANK2, MECP2
regulation of apoptotic process (GO:0042981) 2.53CHD8, EN2, MECP2
synapse assembly (GO:0007416) 5.553NLGN3, SHANK2, MECP2
regulation of neurogenesis (GO:0050767) 3.213NLGN3, MECP2, EIF4E
negative regulation of macromolecule metabolic process (GO:0010605) 2.013CHD8, MECP2, EIF4E
negative regulation of signal transduction (GO:0009968) 2.753CHD8, NLGN3, NLGN4X
regulation of signal transduction (GO:0009966) 1.843CHD8, NLGN3, NLGN4X
organic cyclic compound biosynthetic process (GO:1901362) 1.663CHD8, RPL10, MECP2
positive regulation of multicellular organismal process (GO:0051240) 2.493MET, NLGN3, MECP2
negative regulation of multicellular organismal process (GO:0051241) 2.843NLGN3, MECP2, EIF4E
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.63CHD8, MECP2, EIF4E
negative regulation of neurogenesis (GO:0050768) 4.223NLGN3, MECP2, EIF4E
regulation of synapse structure or activity (GO:0050803) 4.773NLGN3, SHANK2, MECP2
negative regulation of cellular biosynthetic process (GO:0031327) 2.493CHD8, MECP2, EIF4E
negative regulation of apoptotic process (GO:0043066) 3.043CHD8, EN2, MECP2
negative regulation of cell development (GO:0010721) 4.023NLGN3, MECP2, EIF4E
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.813MET, CHD8, EN2
macromolecule localization (GO:0033036) 2.343CNTNAP2, RPL10, MECP2
heterocycle biosynthetic process (GO:0018130) 1.73CHD8, RPL10, MECP2
neuron differentiation (GO:0030182) 4.173EN2, NLGN4X, MECP2
regulation of developmental process (GO:0050793) 2.13NLGN3, MECP2, EIF4E
organic substance transport (GO:0071702) 2.153RPL10, MECP2, EIF4E
negative regulation of cell differentiation (GO:0045596) 3.333NLGN3, MECP2, EIF4E
single-organism transport (GO:0044765) 2.183RPL10, MECP2, SLC9A9
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.473CHD8, MECP2, EIF4E
nucleobase-containing compound biosynthetic process (GO:0034654) 1.723CHD8, RPL10, MECP2
single-organism localization (GO:1902578) 2.093RPL10, MECP2, SLC9A9
cellular localization (GO:0051641) 2.323CNTNAP2, RPL10, EIF4E
negative regulation of developmental process (GO:0051093) 3.173NLGN3, MECP2, EIF4E
biological adhesion (GO:0022610) 2.813CNTNAP2, NLGN4X, NLGN3
brain development (GO:0007420) 4.243CNTNAP2, CHD8, MECP2
organonitrogen compound biosynthetic process (GO:1901566) 2.853TMLHE, RPL10, EIF4E
long-term synaptic potentiation (GO:0060291) 6.073NLGN3, SHANK2, MECP2
response to stimulus (GO:0050896) 1.223NLGN3, MECP2, EIF4E
regulation of synaptic plasticity (GO:0048167) 4.783NLGN3, SHANK2, MECP2
negative regulation of nervous system development (GO:0051961) 4.153NLGN3, MECP2, EIF4E
regulation of nervous system development (GO:0051960) 3.13NLGN3, MECP2, EIF4E
regulation of multicellular organismal development (GO:2000026) 2.313NLGN3, MECP2, EIF4E
aromatic compound biosynthetic process (GO:0019438) 1.73CHD8, RPL10, MECP2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.533CHD8, MECP2, EIF4E
signal transduction (GO:0007165) 1.283MET, PTCHD1, CHD8
developmental growth (GO:0048589) 4.052NLGN4X, NLGN3
positive regulation of response to stimulus (GO:0048584) 2.182MET, NLGN3
regulation of neuron apoptotic process (GO:0043523) 4.472EN2, MECP2
negative regulation of neuron apoptotic process (GO:0043524) 4.822EN2, MECP2
organic cyclic compound catabolic process (GO:1901361) 3.732RPL10, EIF4E
single-organism metabolic process (GO:0044710) 1.632TMLHE, MECP2
cellular macromolecule localization (GO:0070727) 3.12CNTNAP2, RPL10
peptide biosynthetic process (GO:0043043) 3.732RPL10, EIF4E
presynaptic membrane assembly (GO:0097105) 7.532NLGN4X, NLGN3
negative regulation of neuron differentiation (GO:0045665) 4.452NLGN3, EIF4E
regulation of neuron differentiation (GO:0045664) 3.392NLGN3, EIF4E
amide biosynthetic process (GO:0043604) 3.62RPL10, EIF4E
oxidation-reduction process (GO:0055114) 2.912TMLHE, MECP2
single organism signaling (GO:0044700) 3.252CNTNAP2, MECP2
multicellular organismal response to stress (GO:0033555) 5.672MECP2, EIF4E
aromatic compound catabolic process (GO:0019439) 3.792RPL10, EIF4E
signaling (GO:0023052) 3.252CNTNAP2, MECP2
visual behavior (GO:0007632) 5.822NLGN3, MECP2
presynaptic membrane organization (GO:0097090) 7.432NLGN4X, NLGN3
neuron projection development (GO:0031175) 4.582CNTNAP2, MECP2
nucleic acid-templated transcription (GO:0097659) 1.912CHD8, MECP2
organic substance catabolic process (GO:1901575) 2.452RPL10, EIF4E
cellular macromolecule catabolic process (GO:0044265) 3.192RPL10, EIF4E
behavioral defense response (GO:0002209) 6.432MECP2, EIF4E
regulation of molecular function (GO:0065009) 1.782TMLHE, NLGN3
positive regulation of cellular component organization (GO:0051130) 2.682NLGN3, MECP2
single organism cell adhesion (GO:0098602) 3.632NLGN4X, NLGN3
cell-cell adhesion (GO:0098609) 3.342NLGN4X, NLGN3
heterocycle catabolic process (GO:0046700) 3.822RPL10, EIF4E
defense response (GO:0006952) 2.782MECP2, EIF4E
macromolecule modification (GO:0043412) 1.732MET, MECP2
protein modification process (GO:0036211) 1.792MET, MECP2
excitatory postsynaptic potential (GO:0060079) 6.432NLGN3, MECP2
nucleobase-containing compound catabolic process (GO:0034655) 3.92RPL10, EIF4E
regulation of neuron death (GO:1901214) 4.192EN2, MECP2
cerebellum development (GO:0021549) 5.82NLGN4X, MECP2
mRNA metabolic process (GO:0016071) 3.332RPL10, EIF4E
cellular nitrogen compound catabolic process (GO:0044270) 3.82RPL10, EIF4E
intracellular transport (GO:0046907) 2.672RPL10, EIF4E
response to stress (GO:0006950) 1.82MECP2, EIF4E
regulation of synapse assembly (GO:0051963) 5.362NLGN3, MECP2
positive regulation of nervous system development (GO:0051962) 3.642NLGN3, MECP2
associative learning (GO:0008306) 5.442NLGN3, MECP2
transcription, DNA-templated (GO:0006351) 1.912CHD8, MECP2
positive regulation of synapse assembly (GO:0051965) 5.622NLGN3, MECP2
peptide metabolic process (GO:0006518) 3.442RPL10, EIF4E
response to radiation (GO:0009314) 3.692NLGN3, MECP2
regulation of synapse organization (GO:0050807) 5.032NLGN3, MECP2
negative regulation of cellular component organization (GO:0051129) 3.352NLGN3, MECP2
regulation of cellular component organization (GO:0051128) 2.012NLGN3, MECP2
cellular catabolic process (GO:0044248) 2.622RPL10, EIF4E
response to light stimulus (GO:0009416) 4.082NLGN3, MECP2
peptidyl-amino acid modification (GO:0018193) 2.982MET, MECP2
regulation of postsynaptic membrane potential (GO:0060078) 5.722NLGN3, MECP2
visual learning (GO:0008542) 5.922NLGN3, MECP2
behavioral fear response (GO:0001662) 6.432MECP2, EIF4E
negative regulation of protein metabolic process (GO:0051248) 2.822MECP2, EIF4E
negative regulation of neuron death (GO:1901215) 4.572EN2, MECP2
regulation of system process (GO:0044057) 3.532NLGN3, MECP2
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122CHD8, MECP2
regulation of protein metabolic process (GO:0051246) 1.932MECP2, EIF4E
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712CHD8, MECP2
negative regulation of transcription, DNA-templated (GO:0045892) 2.752CHD8, MECP2
regulation of localization (GO:0032879) 1.942MET, NLGN3
regulation of respiratory gaseous exchange (GO:0043576) 6.592NLGN3, MECP2
regulation of respiratory system process (GO:0044065) 6.962NLGN3, MECP2
negative regulation of cellular protein metabolic process (GO:0032269) 2.882MECP2, EIF4E
regulation of cellular protein metabolic process (GO:0032268) 1.992MECP2, EIF4E
cellular amide metabolic process (GO:0043603) 3.232RPL10, EIF4E
positive regulation of developmental process (GO:0051094) 2.772NLGN3, MECP2
negative regulation of RNA metabolic process (GO:0051253) 2.662CHD8, MECP2
modulation of excitatory postsynaptic potential (GO:0098815) 6.332NLGN4X, NLGN3
nuclear-transcribed mRNA catabolic process (GO:0000956) 4.492RPL10, EIF4E
system development (GO:0048731) 2.922CNTNAP2, MECP2
single organismal cell-cell adhesion (GO:0016337) 3.692NLGN4X, NLGN3
cell projection organization (GO:0030030) 3.142CNTNAP2, MECP2
fear response (GO:0042596) 6.362MECP2, EIF4E
regulation of respiratory gaseous exchange by neurological system process (GO:0002087) 7.162NLGN3, MECP2
multicellular organism development (GO:0007275) 2.542CHD8, EN2
growth (GO:0040007) 3.82NLGN4X, NLGN3
chromatin organization (GO:0006325) 3.282CHD8, MECP2
nitrogen compound transport (GO:0071705) 3.542MECP2, EIF4E
RNA catabolic process (GO:0006401) 4.32RPL10, EIF4E
mRNA catabolic process (GO:0006402) 4.432RPL10, EIF4E
membrane assembly (GO:0071709) 6.592NLGN4X, NLGN3
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552CHD8, MECP2
cellular protein localization (GO:0034613) 3.112CNTNAP2, RPL10
cellular protein modification process (GO:0006464) 1.792MET, MECP2
negative regulation of RNA biosynthetic process (GO:1902679) 2.72CHD8, MECP2
neuron cell-cell adhesion (GO:0007158) 6.962NLGN4X, NLGN3
establishment of localization in cell (GO:0051649) 2.472RPL10, EIF4E
catabolic process (GO:0009056) 2.382RPL10, EIF4E
macromolecule catabolic process (GO:0009057) 3.02RPL10, EIF4E
response to abiotic stimulus (GO:0009628) 2.82NLGN3, MECP2
negative regulation of excitatory postsynaptic potential (GO:0090394) 7.532NLGN4X, NLGN3
regulation of cellular component biogenesis (GO:0044087) 3.082NLGN3, MECP2
phosphate-containing compound metabolic process (GO:0006796) 2.162MET, MECP2
phosphorus metabolic process (GO:0006793) 2.152MET, MECP2
translational initiation (GO:0006413) 4.722RPL10, EIF4E
translation (GO:0006412) 3.792RPL10, EIF4E
positive regulation of cellular component biogenesis (GO:0044089) 3.712NLGN3, MECP2

NET-GE enrichment

Term New enriched termICP valueGenes
synapse organization (GO:0050808) -4.870.001CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
presynaptic membrane organization (GO:0097090) -7.430.021NLGN4X, NLGN3
regulation of postsynaptic membrane potential (GO:0060078) -5.720.006NLGN4X, NLGN3, MECP2
learning (GO:0007612) -4.850.0CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
positive regulation of synaptic transmission (GO:0050806) -5.070.01NLGN3, SHANK2, MECP2
behavior (GO:0007610) -3.470.0NLGN4X, MET, SHANK2, NLGN3, MECP2, CNTNAP2
learning or memory (GO:0007611) -4.330.0CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
regulation of excitatory postsynaptic membrane potential (GO:0060079) -6.430.004NLGN4X, NLGN3, MECP2
membrane depolarization (GO:0051899) NEW5.620.034NLGN4X, NLGN3, MECP2
regulation of respiratory gaseous exchange by neurological system process (GO:0002087) -7.160.025NLGN3, MECP2
regulation of extent of cell growth (GO:0061387) NEW5.090.018EN2, NLGN3, MECP2, EIF4E
synapse assembly (GO:0007416) -5.550.004NLGN3, SHANK2, MECP2
presynaptic membrane assembly (GO:0097105) -7.530.015NLGN4X, NLGN3
multi-organism process (GO:0051704) -2.650.007NLGN4X, SHANK2, RPL10, NLGN3, MECP2, EIF4E, CNTNAP2
membrane assembly (GO:0071709) -6.590.025NLGN4X, NLGN3
vocalization behavior (GO:0071625) -7.090.0CNTNAP2, NLGN4X, NLGN3, SHANK2
regulation of respiratory system process (GO:0044065) -6.960.039NLGN3, MECP2
social behavior (GO:0035176) -5.90.0CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
neurological system process (GO:0050877) -2.640.004NLGN4X, PTCHD1, MECP2, NLGN3, SHANK2, CNTNAP2
neuron cell-cell adhesion (GO:0007158) -6.960.044NLGN4X, NLGN3
intraspecies interaction between organisms (GO:0051703) -5.90.0CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
regulation of axon extension (GO:0030516) NEW5.240.006EN2, NLGN3, MECP2, EIF4E
multi-organism behavior (GO:0051705) -5.60.0CNTNAP2, NLGN4X, NLGN3, SHANK2, MECP2
system process (GO:0003008) -2.30.044NLGN4X, PTCHD1, MECP2, NLGN3, SHANK2, CNTNAP2
adult behavior (GO:0030534) -4.790.001NLGN4X, MET, SHANK2, NLGN3, MECP2, CNTNAP2
single-organism behavior (GO:0044708) -3.790.0CHD8, MET, NLGN4X, MECP2, NLGN3, SHANK2, CNTNAP2
cognition (GO:0050890) -4.20.01NLGN4X, PTCHD1, MECP2, NLGN3, SHANK2, CNTNAP2
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1113CHD8, TMLHE, SLC9A9, SHANK2, MET, PTCHD1, NLGN4X, MECP2, EN2, NLGN3, RPL10, EIF4E, CNTNAP2
intracellular part (GO:0044424) 0.2811CHD8, TMLHE, SLC9A9, SHANK2, NLGN4X, MECP2, EN2, NLGN3, RPL10, EIF4E, CNTNAP2
intracellular organelle (GO:0043229) 0.5111CHD8, TMLHE, SLC9A9, SHANK2, NLGN4X, MECP2, EN2, NLGN3, RPL10, EIF4E, CNTNAP2
organelle (GO:0043226) 0.411CHD8, TMLHE, SLC9A9, SHANK2, NLGN4X, MECP2, EN2, NLGN3, RPL10, EIF4E, CNTNAP2
membrane (GO:0016020) 0.689NLGN4X, SLC9A9, MET, PTCHD1, RPL10, EN2, NLGN3, SHANK2, CNTNAP2
membrane-bounded organelle (GO:0043227) 0.479CHD8, TMLHE, SLC9A9, MECP2, EN2, NLGN3, RPL10, EIF4E, CNTNAP2
cytoplasmic part (GO:0044444) 0.828TMLHE, SLC9A9, SHANK2, RPL10, NLGN3, MECP2, EIF4E, CNTNAP2
intracellular membrane-bounded organelle (GO:0043231) 0.68CHD8, TMLHE, SLC9A9, MECP2, EN2, NLGN3, RPL10, CNTNAP2
membrane part (GO:0044425) 0.957NLGN4X, SLC9A9, MET, PTCHD1, SHANK2, NLGN3, CNTNAP2
integral component of membrane (GO:0016021) 1.147NLGN4X, SLC9A9, MET, PTCHD1, SHANK2, NLGN3, CNTNAP2
intrinsic component of membrane (GO:0031224) 1.137NLGN4X, SLC9A9, MET, PTCHD1, SHANK2, NLGN3, CNTNAP2
intracellular organelle part (GO:0044446) 0.816CHD8, TMLHE, SLC9A9, SHANK2, RPL10, MECP2
macromolecular complex (GO:0032991) 1.356CHD8, SHANK2, RPL10, MECP2, EIF4E, CNTNAP2
organelle part (GO:0044422) 0.796CHD8, TMLHE, SLC9A9, SHANK2, RPL10, MECP2
protein complex (GO:0043234) 1.515CNTNAP2, CHD8, MECP2, EIF4E, SHANK2
plasma membrane part (GO:0044459) 1.955MET, CNTNAP2, NLGN4X, NLGN3, SHANK2
plasma membrane (GO:0005886) 1.395MET, NLGN4X, NLGN3, PTCHD1, SHANK2
plasma membrane region (GO:0098590) 2.974MET, CNTNAP2, NLGN4X, SHANK2
non-membrane-bounded organelle (GO:0043228) 1.764NLGN4X, RPL10, EIF4E, SHANK2
intracellular non-membrane-bounded organelle (GO:0043232) 1.764NLGN4X, RPL10, EIF4E, SHANK2
cell surface (GO:0009986) 3.444MET, CNTNAP2, NLGN4X, NLGN3
neuron part (GO:0097458) 2.644CNTNAP2, NLGN4X, NLGN3, SHANK2
synapse part (GO:0044456) 3.424NLGN4X, NLGN3, SHANK2, MECP2
neuron projection (GO:0043005) 3.124CNTNAP2, NLGN4X, NLGN3, SHANK2
cell projection (GO:0042995) 2.474CNTNAP2, NLGN4X, NLGN3, SHANK2
extracellular region part (GO:0044421) 1.574NLGN4X, NLGN3, MECP2, EIF4E
cytoplasm (GO:0005737) 1.013MECP2, EIF4E, SHANK2
extracellular space (GO:0005615) 2.633NLGN4X, NLGN3, MECP2
intrinsic component of plasma membrane (GO:0031226) 2.533MET, NLGN4X, NLGN3
cytosol (GO:0005829) 1.683RPL10, MECP2, EIF4E
cell body (GO:0044297) 3.743CNTNAP2, NLGN3, SHANK2
dendrite (GO:0030425) 3.923CNTNAP2, NLGN4X, NLGN3
postsynapse (GO:0098794) 4.873NLGN3, SHANK2, MECP2
synapse (GO:0045202) 3.583NLGN4X, NLGN3, SHANK2
integral component of plasma membrane (GO:0005887) 2.573MET, NLGN4X, NLGN3
neuronal cell body (GO:0043025) 3.93CNTNAP2, NLGN3, SHANK2
nucleus (GO:0005634) 1.073CHD8, EN2, MECP2
cell junction (GO:0030054) 2.753NLGN4X, NLGN3, SHANK2
postsynaptic specialization (GO:0099572) 4.772NLGN4X, SHANK2
ion channel complex (GO:0034702) 4.182CNTNAP2, SHANK2
intracellular ribonucleoprotein complex (GO:0030529) 3.192RPL10, EIF4E
synaptic membrane (GO:0097060) 4.222NLGN4X, SHANK2
vesicle (GO:0031982) 1.642NLGN3, EIF4E
vacuole (GO:0005773) 2.922CNTNAP2, SLC9A9
mitochondrion (GO:0005739) 2.422TMLHE, MECP2
membrane-bounded vesicle (GO:0031988) 1.712NLGN3, EIF4E
transmembrane transporter complex (GO:1902495) 4.062CNTNAP2, SHANK2
transporter complex (GO:1990351) 4.042CNTNAP2, SHANK2
bounding membrane of organelle (GO:0098588) 2.392SLC9A9, SHANK2
cell projection membrane (GO:0031253) 4.112CNTNAP2, SHANK2
postsynaptic membrane (GO:0045211) 4.472NLGN4X, SHANK2
postsynaptic density (GO:0014069) 4.772NLGN4X, SHANK2
excitatory synapse (GO:0060076) 6.622NLGN4X, NLGN3
organelle membrane (GO:0031090) 1.972SLC9A9, SHANK2
cell projection part (GO:0044463) 2.972CNTNAP2, SHANK2
ribonucleoprotein complex (GO:1990904) 3.192RPL10, EIF4E
plasma membrane protein complex (GO:0098797) 3.552CNTNAP2, SHANK2
membrane protein complex (GO:0098796) 2.842CNTNAP2, SHANK2
nuclear part (GO:0044428) 1.552CHD8, MECP2
endosome (GO:0005768) 3.252CNTNAP2, SLC9A9

NET-GE enrichment

Term New enriched termICP valueGenes
cell surface (GO:0009986) -3.440.035MET, CNTNAP2, NLGN4X, NLGN3
excitatory synapse (GO:0060076) -6.620.047NLGN4X, NLGN3