Disease table of MULTIPLE ACYL-COA DEHYDROGENASE DEFICIENCY OMIM ID: 231680

Gene-disease associations table

GeneAssociated with MULTIPLE ACYL-COA DEHYDROGENASE DEFICIENCY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
ETFAOMIM, HUMSAVARHGNC link15q24.31231680
ETFBOMIM, HUMSAVARHGNC link19q13.411231680
ETFDHClinVar, OMIM, HUMSAVARHGNC link4q32.11231680

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ETFAETFBYes6GPX4, HADH, NTRK1, DYNLT1, GRHPR, CUL7

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
ETFAETFBYesbinding1ETFDH
ETFAETFDHYescatalysis, binding1ETFB
ETFBETFDHYescatalysis1ETFA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
ETFAETFBYes0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
ETFAETFBYes3ACADM, ETFB, ETFA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.343ETFDH, ETFB, ETFA
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.713ETFDH, ETFB, ETFA
Respiratory electron transportR-HSA-6111056.443ETFDH, ETFB, ETFA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.123ETFDH, ETFB, ETFA

NET-GE enrichment

Term New enriched termICP valueGenes
The citric acid (TCA) cycle and respiratory electron transport (R-HSA-1428517) -5.710.0ETFDH, ETFB, ETFA
Respiratory electron transport (R-HSA-611105) -6.440.0ETFDH, ETFB, ETFA
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (R-HSA-163200) -6.120.0ETFDH, ETFB, ETFA
Metabolism (R-HSA-1430728) -2.340.039ETFDH, ETFB, ETFA
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
electron carrier activity (GO:0009055) 4.973ETFDH, ETFB, ETFA
coenzyme binding (GO:0050662) 4.532ETFDH, ETFA
flavin adenine dinucleotide binding (GO:0050660) 5.412ETFDH, ETFA
organic cyclic compound binding (GO:0097159) 1.052ETFDH, ETFA
nucleotide binding (GO:0000166) 1.962ETFDH, ETFA
small molecule binding (GO:0036094) 1.892ETFDH, ETFA
catalytic activity (GO:0003824) 1.052ETFDH, ETFA
cofactor binding (GO:0048037) 4.162ETFDH, ETFA
binding (GO:0005488) 0.182ETFDH, ETFA
heterocyclic compound binding (GO:1901363) 1.062ETFDH, ETFA
nucleoside phosphate binding (GO:1901265) 1.962ETFDH, ETFA
oxidoreductase activity (GO:0016491) 3.122ETFDH, ETFA

NET-GE enrichment

Term New enriched termICP valueGenes
coenzyme binding (GO:0050662) -4.530.011ETFDH, ETFA
flavin adenine dinucleotide binding (GO:0050660) -5.410.002ETFDH, ETFA
cofactor binding (GO:0048037) -4.160.002ETFDH, ETFB, ETFA
electron carrier activity (GO:0009055) -4.970.0ETFDH, ETFB, ETFA
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
lipid oxidation (GO:0034440) 5.473ETFDH, ETFB, ETFA
fatty acid metabolic process (GO:0006631) 4.033ETFDH, ETFB, ETFA
fatty acid beta-oxidation (GO:0006635) 5.783ETFDH, ETFB, ETFA
carboxylic acid metabolic process (GO:0019752) 3.123ETFDH, ETFB, ETFA
cellular catabolic process (GO:0044248) 2.623ETFDH, ETFB, ETFA
fatty acid catabolic process (GO:0009062) 5.483ETFDH, ETFB, ETFA
small molecule metabolic process (GO:0044281) 2.383ETFDH, ETFB, ETFA
small molecule catabolic process (GO:0044282) 3.993ETFDH, ETFB, ETFA
generation of precursor metabolites and energy (GO:0006091) 4.073ETFDH, ETFB, ETFA
cellular lipid catabolic process (GO:0044242) 4.733ETFDH, ETFB, ETFA
single-organism process (GO:0044699) 0.483ETFDH, ETFB, ETFA
single-organism catabolic process (GO:0044712) 3.213ETFDH, ETFB, ETFA
single-organism metabolic process (GO:0044710) 1.633ETFDH, ETFB, ETFA
catabolic process (GO:0009056) 2.383ETFDH, ETFB, ETFA
lipid catabolic process (GO:0016042) 4.213ETFDH, ETFB, ETFA
organic substance metabolic process (GO:0071704) 0.633ETFDH, ETFB, ETFA
electron transport chain (GO:0022900) 5.093ETFDH, ETFB, ETFA
respiratory electron transport chain (GO:0022904) 5.113ETFDH, ETFB, ETFA
lipid metabolic process (GO:0006629) 2.683ETFDH, ETFB, ETFA
cellular process (GO:0009987) 0.263ETFDH, ETFB, ETFA
organic substance catabolic process (GO:1901575) 2.453ETFDH, ETFB, ETFA
monocarboxylic acid metabolic process (GO:0032787) 3.573ETFDH, ETFB, ETFA
single-organism cellular process (GO:0044763) 0.653ETFDH, ETFB, ETFA
metabolic process (GO:0008152) 0.583ETFDH, ETFB, ETFA
monocarboxylic acid catabolic process (GO:0072329) 5.263ETFDH, ETFB, ETFA
oxoacid metabolic process (GO:0043436) 3.123ETFDH, ETFB, ETFA
fatty acid oxidation (GO:0019395) 5.483ETFDH, ETFB, ETFA
cellular lipid metabolic process (GO:0044255) 2.923ETFDH, ETFB, ETFA
lipid modification (GO:0030258) 4.373ETFDH, ETFB, ETFA
oxidation-reduction process (GO:0055114) 2.913ETFDH, ETFB, ETFA
primary metabolic process (GO:0044238) 0.693ETFDH, ETFB, ETFA
organic acid metabolic process (GO:0006082) 3.013ETFDH, ETFB, ETFA
carboxylic acid catabolic process (GO:0046395) 4.583ETFDH, ETFB, ETFA
organic acid catabolic process (GO:0016054) 4.443ETFDH, ETFB, ETFA
cellular metabolic process (GO:0044237) 0.693ETFDH, ETFB, ETFA
fatty acid beta-oxidation using acyl-CoA dehydrogenase (GO:0033539) 6.843ETFDH, ETFB, ETFA

NET-GE enrichment

Term New enriched termICP valueGenes
lipid oxidation (GO:0034440) -5.470.018ETFDH, ETFA
fatty acid beta-oxidation (GO:0006635) -5.780.008ETFDH, ETFA
fatty acid beta-oxidation using acyl-CoA dehydrogenase (GO:0033539) -6.840.0ETFDH, ETFA
monocarboxylic acid catabolic process (GO:0072329) -5.260.029ETFDH, ETFA
fatty acid catabolic process (GO:0009062) -5.480.018ETFDH, ETFA
electron transport chain (GO:0022900) -5.090.0ETFDH, ETFB, ETFA
respiratory electron transport chain (GO:0022904) -5.110.0ETFDH, ETFB, ETFA
fatty acid oxidation (GO:0019395) -5.480.017ETFDH, ETFA
generation of precursor metabolites and energy (GO:0006091) -4.070.012ETFDH, ETFB, ETFA
oxidation-reduction process (GO:0055114) -2.910.008ETFDH, ETFB, ETFA
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.63ETFDH, ETFB, ETFA
organelle lumen (GO:0043233) 3.053ETFDH, ETFB, ETFA
cell part (GO:0044464) 0.113ETFDH, ETFB, ETFA
cytoplasmic part (GO:0044444) 0.823ETFDH, ETFB, ETFA
mitochondrion (GO:0005739) 2.423ETFDH, ETFB, ETFA
intracellular organelle part (GO:0044446) 0.813ETFDH, ETFB, ETFA
intracellular organelle lumen (GO:0070013) 3.053ETFDH, ETFB, ETFA
intracellular organelle (GO:0043229) 0.513ETFDH, ETFB, ETFA
membrane-enclosed lumen (GO:0031974) 3.053ETFDH, ETFB, ETFA
mitochondrial matrix (GO:0005759) 4.033ETFDH, ETFB, ETFA
intracellular part (GO:0044424) 0.283ETFDH, ETFB, ETFA
membrane-bounded organelle (GO:0043227) 0.473ETFDH, ETFB, ETFA
organelle (GO:0043226) 0.43ETFDH, ETFB, ETFA
organelle part (GO:0044422) 0.793ETFDH, ETFB, ETFA
mitochondrial part (GO:0044429) 2.923ETFDH, ETFB, ETFA
extracellular organelle (GO:0043230) 1.892ETFB, ETFA
extracellular exosome (GO:0070062) 1.892ETFB, ETFA
membrane-bounded vesicle (GO:0031988) 1.712ETFB, ETFA
extracellular vesicle (GO:1903561) 1.892ETFB, ETFA
extracellular region part (GO:0044421) 1.572ETFB, ETFA
vesicle (GO:0031982) 1.642ETFB, ETFA

NET-GE enrichment

Term New enriched termICP valueGenes
organelle lumen (GO:0043233) -3.050.001ETFDH, ETFB, ETFA
membrane-enclosed lumen (GO:0031974) -3.050.045ETFDH, ETFB, ETFA
mitochondrial membrane part (GO:0044455) NEW4.540.016ETFDH, ETFA
intracellular organelle lumen (GO:0070013) -3.050.028ETFDH, ETFB, ETFA
mitochondrial part (GO:0044429) -2.920.034ETFDH, ETFB, ETFA
mitochondrial matrix (GO:0005759) -4.030.001ETFDH, ETFB, ETFA