Gene table of EPHX2 : epoxide hydrolase 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with EPHX2	OMIM link	Number of associated genes	genes
143890	HYPERCHOLESTEROLEMIA, FAMILIAL	ClinVar, OMIM	link to OMIM	10	APOA2, ITIH4, EPHX2, PCSK9, STAP1, PPP1R17, ABCA1, APOB, LDLR, GHR

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Arachidonic acid metabolism	hsa00590	6.79
Metabolic pathways	hsa01100	2.49
Peroxisome	hsa04146	6.34

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79
Arachidonic acid metabolism	R-HSA-2142753	7.34
Metabolism	R-HSA-1430728	2.34
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)	R-HSA-2142670	9.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
epoxide hydrolase activity	GO:0004301	8.13
metal ion binding	GO:0046872	1.41
phosphatase activity	GO:0016791	4.11
10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity	GO:0033885	9.74
hydrolase activity	GO:0016787	1.9
hydrolase activity, acting on ether bonds	GO:0016801	7.34
ether hydrolase activity	GO:0016803	7.66
magnesium ion binding	GO:0000287	4.41
toxic substance binding	GO:0015643	7.25
cation binding	GO:0043169	1.4
hydrolase activity, acting on ester bonds	GO:0016788	3.1
ion binding	GO:0043167	1.36
phosphoric ester hydrolase activity	GO:0042578	3.82
catalytic activity	GO:0003824	1.05
binding	GO:0005488	0.18
protein binding	GO:0005515	0.46
protein dimerization activity	GO:0046983	2.72
protein homodimerization activity	GO:0042803	3.16
receptor binding	GO:0005102	2.43
identical protein binding	GO:0042802	2.63
lipid phosphatase activity	GO:0042577	7.44