Disease table of HYPERCHOLESTEROLEMIA, FAMILIAL OMIM ID: 143890

Gene-disease associations table

GeneAssociated with HYPERCHOLESTEROLEMIA, FAMILIAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
EPHX2ClinVar, OMIMHGNC link8p21.21143890
PCSK9ClinVarHGNC link1p32.32603776, 143890
APOBClinVarHGNC link2p24.13144010, 143890, 615558
GHRClinVar, OMIMHGNC link5p13.14604271, 262500, 143890, 615925
STAP1ClinVarHGNC link4q13.21143890
LDLRClinVar, OMIM, HUMSAVARHGNC link19p13.21143890
PPP1R17OMIMHGNC link7p14.31143890
ABCA1OMIMHGNC link9q31.13205400, 143890, 604091
ITIH4OMIMHGNC link3p21.11143890
APOA2ClinVar, OMIMHGNC link1q23.31143890

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
12PCSK9, APOA2
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
SREBF2NO20ABCG5, ACOT7, LRP1, NPC1L1, FABP6, FAS, ABCA1, FDFT1, PCSK9, LDLR, PRSS8, HMGCR, FDPS, PON2, ABCG8, HNF4A, MTTP, PPARG, PON1, LIPC3ABCA1, PCSK9, LDLR
NR2F6NO5LHCGR, APOC3, CYP19A1, APOA2, APOB2APOA2, APOB
NR2F1NO8APOC3, CYP19A1, SERPINC1, APOA2, CYP17A1, DR1, LHCGR, APOB2APOA2, APOB
USF2NO42PF4, FCER1A, CTSB, IGF2R, NR5A1, CEACAM1, MYH9, TRAP, ASPH, CEACAM5, TOP3A, PTGS2, PDX1, CYP19A1, HOXB4, THBS1, CFTR, TCN2, TGFB1, PKLR, FMR1, SLC19A1, APC, CD2, TGFB2, PIGR, CTSD, ASCL2, PTPN6, CXCR4, BRCA1, FBP1, BRCA2, CXCR2, ATP5A1, APOA2, APOA5, B2M, HMOX1, TERT, ABCA1, LIPC2ABCA1, APOA2
USF1NO58PF4, FCER1A, CEACAM5, FMO3, ID4, SCN9A, ASCL2, CEACAM1, MYH9, AGT, APOA2, SERPINE1, TBX21, TOP3A, PTGS2, CYP19A1, ISG20, GCK, CTSB, CXCR4, EXT1, TCN2, SLC22A2, TGFB1, PKLR, FMR1, SLC19A1, APC, SLC16A1, TYMS, CCNB1, TGFB2, PIGR, CYP1A1, CTSD, HOXB7, TRAP, IFNG, PTPN6, NPHS2, GATA5, FBP1, S100A6, BRCA2, HOXB4, ABCA1, SERBP1, TERT, ASPH, APOA5, B2M, HMOX1, CD2, CIITA, APEX1, PTGDS, SLC1A3, LIPC2ABCA1, APOA2
SP1NO460ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC12ABCA1, LDLR
HNF4ANO43GPR39, TBP, CYP2C9, CEACAM1, KCNJ11, LDLR, SHBG, APOA1, UGT2B7, MMP7, CYP7A1, HNF1A, ABCC6, SERPINC1, GH1, PCSK9, CYP2B6, NR1I2, CYP2D6, ABCG8, PPARA, APOB, ABCG5, CDKN1A, AFP, CYP27A1, ACMSD, SLC26A3, RNASE2, SLC22A6, UGT1A7, AKR1C4, GCK, NPC1L1, C1QTNF5, APOA2, APOC3, ACAT2, CYP2C8, FABP2, GFER, MYC, LIPC4APOA2, PCSK9, APOB, LDLR
SREBF1NO27AR, FABP6, LPIN1, BCL2L1, CAV1, ACACB, SCD, THRSP, CIC, PDX1, SCD5, FAS, PCSK9, LDLR, FDPS, LRP1, IRS2, PCK1, FDFT1, HK2, NR0B2, ACLY, FASN, APOA5, CETP, HMOX1, PPARG2PCSK9, LDLR
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
PCSK9YES3SREBF2, HNF4A, SREBF10
APOBYES6PPARA, NR2F6, NR2F1, HNF4A, PPARG, FOXA10
GHRYES1POU1F10
LDLRYES8SP1, ATF3, KLF13, EGR1, SREBF2, SREBF1, YY1, HNF4A0
ABCA1YES11SP1, SREBF2, NR1H3, USF2, ZNF202, RELA, SP3, RXRA, NFKB1, NR1H2, USF10
APOA2YES5HNF4A, NR2F1, NR2F6, USF1, USF20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
PCSK9APOBNo1PDIA4
PCSK9GHRNo1STUB1
PCSK9LDLRYes1PDIA4
APOBLDLRNo4CANX, PDIA4, HSPA5, HSP90B1
APOBABCA1No1APOA1
APOBAPOA2No1APOA1
GHRITIH4No1GRB2
ABCA1APOA2No1APOA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
APOBGHRNo-3UBC, IL6, PTPN11
APOBABCA1Yesactivation, binding8SP1, LRP1, APOE, SREBF2, APOA1, IL6, UBC, LRP8
APOBITIH4No-2IL6, CANX
APOBAPOA2Yesbinding25LRP8, GPC3, LRP1, GPC2, APOA4, APOA1, GPC4, SP1, APOC3, SDC3, SAR1B, LPL, APOF, GPC6, GPC1, APOE, SDC4, LRP2, GPC5, HSPG2, APOA5, SDC1, P4HB, SDC2, MTTP
GHRSTAP1No-2STAT5B, STAT5A
GHRABCA1No-5UBC, INS, IL6, JAK2, IL10
GHRITIH4No-3IL6, IL2, IL10
ABCA1ITIH4No-2IL6, IL10
ABCA1APOA2No-21SP1, LRP1, CARM1, SMARCD3, APOE, TBL1XR1, NCOA6, PLTP, NR1H3, HELZ2, CHD9, TGS1, MED1, NCOA1, LRP8, NCOA2, APOA1, TBL1X, PPARA, CREBBP, APOB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
PCSK9LDLRYes2PCSK9, LDLR

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Fat digestion and absorptionhsa049757.452ABCA1, APOB

NET-GE enrichment

Term New enriched termICP valueGenes
Fat digestion and absorption (hsa04975) -7.450.002ABCA1, APOB, LDLR
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Metabolism of lipids and lipoproteinsR-HSA-5568333.795APOA2, EPHX2, ABCA1, APOB, LDLR
MetabolismR-HSA-14307282.345APOA2, EPHX2, ABCA1, APOB, LDLR
Lipoprotein metabolismR-HSA-1748248.234APOA2, ABCA1, APOB, LDLR
Signal TransductionR-HSA-1625821.784APOA2, APOB, LDLR, GHR
Lipid digestion, mobilization, and transportR-HSA-739237.24APOA2, ABCA1, APOB, LDLR
Retinoid metabolism and transportR-HSA-9756347.593APOA2, APOB, LDLR
Visual phototransductionR-HSA-21873386.443APOA2, APOB, LDLR
Chylomicron-mediated lipid transportR-HSA-1748009.183APOA2, APOB, LDLR
PPARA activates gene expressionR-HSA-19897816.182ABCA1, APOA2
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)R-HSA-4002066.142ABCA1, APOA2
LDL-mediated lipid transportR-HSA-17105210.662APOB, LDLR
Fatty acid, triacylglycerol, and ketone body metabolismR-HSA-5357345.442ABCA1, APOA2

NET-GE enrichment

Term New enriched termICP valueGenes
PPARA activates gene expression (R-HSA-1989781) -6.180.001ABCA1, PCSK9, APOA2, APOB
Lipoprotein metabolism (R-HSA-174824) -8.230.0APOA2, ABCA1, APOB, LDLR
Visual phototransduction (R-HSA-2187338) -6.440.041APOA2, APOB, LDLR
Fatty acid, triacylglycerol, and ketone body metabolism (R-HSA-535734) -5.440.01ABCA1, PCSK9, APOA2, APOB
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) (R-HSA-400206) -6.140.001ABCA1, PCSK9, APOA2, APOB
HDL-mediated lipid transport (R-HSA-194223) NEW9.080.011ABCA1, APOB
Transmembrane transport of small molecules (R-HSA-382551) NEW3.790.044ABCA1, APOA2, PCSK9, APOB, LDLR
Scavenging by Class B Receptors (R-HSA-3000471) NEW10.660.001APOB, LDLR
Retinoid metabolism and transport (R-HSA-975634) -7.590.002APOA2, APOB, LDLR
Lipid digestion, mobilization, and transport (R-HSA-73923) -7.20.0APOA2, ABCA1, APOB, LDLR
Metabolism of lipids and lipoproteins (R-HSA-556833) -3.790.006PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
Metabolism (R-HSA-1430728) -2.340.049APOA2, EPHX2, ABCA1, APOB, LDLR
LDL-mediated lipid transport (R-HSA-171052) -10.660.0APOB, LDLR
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782) NEW5.380.044PCSK9, APOB, LDLR
Chylomicron-mediated lipid transport (R-HSA-174800) -9.180.0APOA2, APOB, LDLR
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.189ITIH4, GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
protein binding (GO:0005515) 0.469ITIH4, GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
receptor binding (GO:0005102) 2.436STAP1, PCSK9, APOA2, EPHX2, ABCA1, APOB
enzyme binding (GO:0019899) 2.275LDLR, ABCA1, APOB, STAP1, GHR
phospholipid binding (GO:0005543) 3.914APOA2, ABCA1, APOB, STAP1
molecular function regulator (GO:0098772) 2.514ITIH4, PCSK9, APOA2, PPP1R17
lipid binding (GO:0008289) 3.264APOA2, ABCA1, APOB, STAP1
identical protein binding (GO:0042802) 2.634APOA2, EPHX2, LDLR, GHR
cholesterol transporter activity (GO:0017127) 7.173ABCA1, APOA2, APOB
molecular transducer activity (GO:0060089) 2.323ABCA1, GHR, LDLR
macromolecular complex binding (GO:0044877) 2.613PCSK9, APOA2, LDLR
receptor activity (GO:0004872) 2.323ABCA1, GHR, LDLR
signal transducer activity (GO:0004871) 2.283ABCA1, GHR, STAP1
enzyme inhibitor activity (GO:0004857) 3.783ITIH4, PPP1R17, APOA2
cation binding (GO:0043169) 1.43APOA2, LDLR, EPHX2
ion binding (GO:0043167) 1.363APOA2, EPHX2, LDLR
transporter activity (GO:0005215) 2.573ABCA1, APOA2, APOB
protein homodimerization activity (GO:0042803) 3.163APOA2, EPHX2, GHR
lipid transporter activity (GO:0005319) 5.033ABCA1, APOA2, APOB
hydrolase activity (GO:0016787) 1.93ABCA1, PCSK9, EPHX2
lipoprotein particle receptor binding (GO:0070325) 6.653PCSK9, APOA2, APOB
enzyme regulator activity (GO:0030234) 2.853ITIH4, APOA2, PPP1R17
catalytic activity (GO:0003824) 1.053ABCA1, PCSK9, EPHX2
protein dimerization activity (GO:0046983) 2.723APOA2, GHR, EPHX2
lipoprotein particle binding (GO:0071813) 6.563PCSK9, APOA2, LDLR
substrate-specific transporter activity (GO:0022892) 2.723ABCA1, APOA2, APOB
protein-lipid complex binding (GO:0071814) 6.563PCSK9, APOA2, LDLR
carbohydrate derivative binding (GO:0097367) 2.033ABCA1, APOB, LDLR
organic cyclic compound binding (GO:0097159) 1.053ABCA1, PCSK9, APOA2
sterol transporter activity (GO:0015248) 6.853ABCA1, APOA2, APOB
small molecule binding (GO:0036094) 1.892ABCA1, APOA2
sterol binding (GO:0032934) 5.982ABCA1, APOA2
signaling receptor activity (GO:0038023) 2.492ABCA1, GHR
cholesterol binding (GO:0015485) 6.12ABCA1, APOA2
alcohol binding (GO:0043178) 5.532ABCA1, APOA2
metal ion binding (GO:0046872) 1.412EPHX2, LDLR
apolipoprotein binding (GO:0034185) 6.972ABCA1, PCSK9
protein kinase binding (GO:0019901) 3.442GHR, STAP1
kinase binding (GO:0019900) 3.322GHR, STAP1
transmembrane signaling receptor activity (GO:0004888) 2.572ABCA1, GHR
low-density lipoprotein particle receptor binding (GO:0050750) 6.912PCSK9, APOB
steroid binding (GO:0005496) 5.242ABCA1, APOA2
apolipoprotein receptor binding (GO:0034190) 7.792PCSK9, APOA2
heterocyclic compound binding (GO:1901363) 1.062ABCA1, PCSK9
transmembrane receptor activity (GO:0099600) 2.532ABCA1, GHR
low-density lipoprotein particle binding (GO:0030169) 7.032PCSK9, LDLR

NET-GE enrichment

Term New enriched termICP valueGenes
lipid transporter activity (GO:0005319) -5.030.002ABCA1, APOA2, APOB
lipase binding (GO:0035473) NEW7.950.004APOB, LDLR
lipoprotein particle binding (GO:0071813) -6.560.0APOA2, PCSK9, APOB, LDLR
sterol binding (GO:0032934) -5.980.027ABCA1, APOA2, APOB
very-low-density lipoprotein particle receptor activity (GO:0030229) NEW8.350.001APOB, LDLR
cholesterol binding (GO:0015485) -6.10.002ABCA1, APOA2, APOB
protein-lipid complex binding (GO:0071814) -6.560.0APOA2, PCSK9, APOB, LDLR
lipoprotein particle receptor binding (GO:0070325) -6.650.0APOA2, PCSK9, APOB, LDLR
serine hydrolase activity (GO:0017171) NEW4.260.027ABCA1, PCSK9, APOB, LDLR
cholesterol transporter activity (GO:0017127) -7.170.0ABCA1, APOA2, APOB
apolipoprotein binding (GO:0034185) -6.970.004ABCA1, PCSK9, APOB
hydrogen ion channel activity (GO:0015252) NEW8.130.0PCSK9, APOB, LDLR
phosphatidylcholine binding (GO:0031210) NEW6.690.0ABCA1, APOA2, APOB
serine-type peptidase activity (GO:0008236) NEW4.270.025ABCA1, PCSK9, APOB, LDLR
steroid binding (GO:0005496) -5.240.001APOA2, ABCA1, APOB, LDLR
low-density lipoprotein particle binding (GO:0030169) -7.030.004PCSK9, APOB, LDLR
low-density lipoprotein particle receptor binding (GO:0050750) -6.910.003PCSK9, APOB, LDLR
lipoprotein particle receptor activity (GO:0030228) NEW6.970.024APOB, LDLR
sterol transporter activity (GO:0015248) -6.850.0ABCA1, APOA2, APOB
apolipoprotein receptor binding (GO:0034190) -7.790.0ABCA1, PCSK9, APOA2, APOB
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
biological regulation (GO:0065007) 0.3910ITIH4, GHR, STAP1, PCSK9, APOA2, LDLR, PPP1R17, EPHX2, ABCA1, APOB
regulation of biological process (GO:0050789) 0.4510ITIH4, GHR, STAP1, PCSK9, APOA2, LDLR, PPP1R17, EPHX2, ABCA1, APOB
regulation of metabolic process (GO:0019222) 1.0210ITIH4, GHR, STAP1, PCSK9, APOA2, LDLR, PPP1R17, EPHX2, ABCA1, APOB
cellular process (GO:0009987) 0.269ITIH4, GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
regulation of primary metabolic process (GO:0080090) 1.089ITIH4, GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
regulation of cellular process (GO:0050794) 0.59ITIH4, STAP1, GHR, PCSK9, APOA2, PPP1R17, LDLR, ABCA1, APOB
positive regulation of metabolic process (GO:0009893) 1.748GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
response to stimulus (GO:0050896) 1.228ITIH4, GHR, STAP1, PCSK9, APOA2, EPHX2, ABCA1, APOB
regulation of cellular metabolic process (GO:0031323) 1.078ITIH4, STAP1, GHR, PCSK9, APOA2, PPP1R17, LDLR, ABCA1
organic substance metabolic process (GO:0071704) 0.638ITIH4, GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
metabolic process (GO:0008152) 0.588ITIH4, GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
positive regulation of biological process (GO:0048518) 1.28GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
response to chemical (GO:0042221) 1.988ITIH4, GHR, STAP1, PCSK9, APOA2, EPHX2, ABCA1, APOB
single-organism process (GO:0044699) 0.488ITIH4, GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
primary metabolic process (GO:0044238) 0.697GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
single-organism metabolic process (GO:0044710) 1.637GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
macromolecule metabolic process (GO:0043170) 0.837ITIH4, GHR, PCSK9, LDLR, APOA2, ABCA1, APOB
lipid metabolic process (GO:0006629) 2.687GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
regulation of macromolecule metabolic process (GO:0060255) 1.087ITIH4, GHR, STAP1, PCSK9, APOA2, EPHX2, APOB
transport (GO:0006810) 1.517ITIH4, GHR, PCSK9, LDLR, APOA2, ABCA1, APOB
localization (GO:0051179) 1.47ITIH4, GHR, PCSK9, LDLR, APOA2, ABCA1, APOB
single-organism cellular process (GO:0044763) 0.657ITIH4, GHR, PCSK9, APOA2, EPHX2, ABCA1, APOB
small molecule metabolic process (GO:0044281) 2.387GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
establishment of localization (GO:0051234) 1.487ITIH4, GHR, PCSK9, LDLR, APOA2, ABCA1, APOB
response to organic substance (GO:0010033) 2.27ITIH4, STAP1, GHR, PCSK9, APOA2, ABCA1, APOB
organic cyclic compound metabolic process (GO:1901360) 1.267GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
positive regulation of cellular process (GO:0048522) 1.37STAP1, GHR, PCSK9, LDLR, APOA2, ABCA1, APOB
response to oxygen-containing compound (GO:1901700) 2.576STAP1, GHR, PCSK9, APOA2, ABCA1, APOB
lipid homeostasis (GO:0055088) 5.06PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
multicellular organismal process (GO:0032501) 1.456GHR, APOA2, LDLR, EPHX2, ABCA1, APOB
positive regulation of macromolecule metabolic process (GO:0010604) 1.816GHR, STAP1, PCSK9, APOA2, EPHX2, APOB
positive regulation of cellular metabolic process (GO:0031325) 1.816STAP1, GHR, PCSK9, APOA2, LDLR, ABCA1
cellular metabolic process (GO:0044237) 0.696GHR, PCSK9, APOA2, EPHX2, ABCA1, APOB
chemical homeostasis (GO:0048878) 2.976PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
homeostatic process (GO:0042592) 2.616PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
single-organism transport (GO:0044765) 2.186ITIH4, GHR, APOA2, LDLR, ABCA1, APOB
negative regulation of cellular process (GO:0048523) 1.416ITIH4, GHR, STAP1, PCSK9, APOA2, ABCA1
cholesterol homeostasis (GO:0042632) 5.66PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
negative regulation of biological process (GO:0048519) 1.336ITIH4, GHR, STAP1, PCSK9, APOA2, ABCA1
regulation of molecular function (GO:0065009) 1.786ITIH4, GHR, STAP1, PCSK9, APOA2, PPP1R17
regulation of biological quality (GO:0065008) 1.686PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
sterol homeostasis (GO:0055092) 5.66PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
single-organism localization (GO:1902578) 2.096ITIH4, GHR, APOA2, LDLR, ABCA1, APOB
regulation of response to stimulus (GO:0048583) 1.545ABCA1, APOA2, PCSK9, GHR, STAP1
lipoprotein metabolic process (GO:0042157) 5.825ABCA1, APOA2, PCSK9, APOB, LDLR
cellular response to chemical stimulus (GO:0070887) 2.575ABCA1, PCSK9, APOB, STAP1, GHR
response to endogenous stimulus (GO:0009719) 2.795ABCA1, APOA2, PCSK9, GHR, APOB
cellular protein metabolic process (GO:0044267) 1.635ABCA1, PCSK9, APOA2, APOB, GHR
cellular response to stimulus (GO:0051716) 1.975ABCA1, PCSK9, APOB, STAP1, GHR
cellular macromolecule metabolic process (GO:0044260) 0.935ABCA1, APOA2, PCSK9, GHR, APOB
response to lipid (GO:0033993) 3.115APOA2, ABCA1, APOB, STAP1, GHR
regulation of protein metabolic process (GO:0051246) 1.935ITIH4, APOA2, PCSK9, GHR, STAP1
cellular response to organic substance (GO:0071310) 2.785ABCA1, PCSK9, APOB, STAP1, GHR
developmental process (GO:0032502) 1.365APOA2, PPP1R17, PCSK9, GHR, APOB
sterol metabolic process (GO:0016125) 4.925ABCA1, APOA2, PCSK9, APOB, LDLR
regulation of catalytic activity (GO:0050790) 1.975APOA2, ITIH4, STAP1, PPP1R17, GHR
organic substance catabolic process (GO:1901575) 2.455APOA2, EPHX2, PCSK9, APOB, LDLR
secondary alcohol metabolic process (GO:1902652) 5.05ABCA1, APOA2, PCSK9, APOB, LDLR
response to stress (GO:0006950) 1.85ITIH4, ABCA1, PCSK9, APOA2, EPHX2
regulation of multicellular organismal process (GO:0051239) 1.875APOA2, PCSK9, EPHX2, STAP1, GHR
cellular lipid metabolic process (GO:0044255) 2.925APOA2, PCSK9, APOB, EPHX2, GHR
regulation of localization (GO:0032879) 1.945ABCA1, APOA2, PCSK9, APOB, STAP1
catabolic process (GO:0009056) 2.385APOA2, EPHX2, PCSK9, APOB, LDLR
steroid metabolic process (GO:0008202) 4.325ABCA1, APOA2, PCSK9, APOB, LDLR
cholesterol metabolic process (GO:0008203) 5.035ABCA1, APOA2, PCSK9, APOB, LDLR
single-multicellular organism process (GO:0044707) 1.785APOA2, ABCA1, APOB, LDLR, GHR
response to external stimulus (GO:0009605) 2.555ABCA1, PCSK9, APOB, STAP1, GHR
protein metabolic process (GO:0019538) 1.455ABCA1, PCSK9, APOA2, APOB, GHR
anatomical structure development (GO:0048856) 1.585APOA2, PCSK9, APOB, PPP1R17, GHR
alcohol metabolic process (GO:0006066) 4.25ABCA1, APOA2, PCSK9, APOB, LDLR
organic hydroxy compound metabolic process (GO:1901615) 3.845ABCA1, APOA2, PCSK9, APOB, LDLR
negative regulation of metabolic process (GO:0009892) 1.934ITIH4, PCSK9, APOA2, STAP1
sterol transport (GO:0015918) 5.844APOA2, ABCA1, APOB, LDLR
organic hydroxy compound transport (GO:0015850) 4.964APOA2, ABCA1, APOB, LDLR
regulation of transport (GO:0051049) 2.244ABCA1, PCSK9, APOA2, STAP1
cholesterol transport (GO:0030301) 5.884APOA2, ABCA1, APOB, LDLR
cellular catabolic process (GO:0044248) 2.624APOA2, PCSK9, APOB, EPHX2
regulation of phosphorus metabolic process (GO:0051174) 2.354ABCA1, PPP1R17, STAP1, GHR
signal transduction (GO:0007165) 1.284PPP1R17, ABCA1, GHR, STAP1
regulation of signaling (GO:0023051) 1.724ABCA1, PCSK9, GHR, STAP1
regulation of phosphate metabolic process (GO:0019220) 2.354ABCA1, PPP1R17, STAP1, GHR
regulation of cell communication (GO:0010646) 1.734ABCA1, PCSK9, GHR, STAP1
regulation of signal transduction (GO:0009966) 1.844ABCA1, PCSK9, GHR, STAP1
lipid transport (GO:0006869) 4.244APOA2, ABCA1, APOB, LDLR
positive regulation of protein metabolic process (GO:0051247) 2.434PCSK9, APOA2, STAP1, GHR
negative regulation of molecular function (GO:0044092) 2.744ITIH4, PCSK9, PPP1R17, APOA2
regulation of lipid metabolic process (GO:0019216) 4.084APOA2, EPHX2, APOB, LDLR
organic substance transport (GO:0071702) 2.154APOA2, ABCA1, APOB, LDLR
regulation of biosynthetic process (GO:0009889) 1.374APOA2, ABCA1, APOB, LDLR
single-organism developmental process (GO:0044767) 1.494PCSK9, APOA2, APOB, GHR
regulation of cell differentiation (GO:0045595) 2.424ABCA1, APOB, STAP1, GHR
cellular response to oxygen-containing compound (GO:1901701) 3.224ABCA1, PCSK9, GHR, STAP1
regulation of cellular protein metabolic process (GO:0032268) 1.994ITIH4, PCSK9, GHR, STAP1
vesicle-mediated transport (GO:0016192) 2.724ITIH4, APOB, LDLR, GHR
response to hormone (GO:0009725) 3.334APOA2, PCSK9, GHR, APOB
phosphate-containing compound metabolic process (GO:0006796) 2.164APOA2, PCSK9, GHR, EPHX2
phosphorus metabolic process (GO:0006793) 2.154APOA2, PCSK9, GHR, EPHX2
plasma lipoprotein particle assembly (GO:0034377) 6.843ABCA1, APOA2, APOB
regulation of catabolic process (GO:0009894) 3.523PCSK9, APOA2, LDLR
cellular component assembly (GO:0022607) 2.143ABCA1, APOA2, APOB
cellular macromolecule biosynthetic process (GO:0034645) 1.663ABCA1, APOA2, APOB
positive regulation of biosynthetic process (GO:0009891) 2.293ABCA1, APOA2, LDLR
macromolecular complex subunit organization (GO:0043933) 2.143ABCA1, APOA2, APOB
regulation of cellular biosynthetic process (GO:0031326) 1.383ABCA1, APOA2, LDLR
acylglycerol metabolic process (GO:0006639) 5.273PCSK9, APOA2, APOB
neutral lipid metabolic process (GO:0006638) 5.263PCSK9, APOA2, APOB
response to extracellular stimulus (GO:0009991) 3.713ABCA1, PCSK9, GHR
regulation of cellular component organization (GO:0051128) 2.013PCSK9, APOA2, STAP1
cellular biosynthetic process (GO:0044249) 1.373ABCA1, APOA2, APOB
nitrogen compound metabolic process (GO:0006807) 1.133ITIH4, APOA2, GHR
positive regulation of gene expression (GO:0010628) 2.353APOB, EPHX2, STAP1
cell surface receptor signaling pathway (GO:0007166) 2.093ABCA1, GHR, STAP1
lipoprotein biosynthetic process (GO:0042158) 7.433ABCA1, APOA2, APOB
macromolecular complex assembly (GO:0065003) 2.553ABCA1, APOA2, APOB
response to lipopolysaccharide (GO:0032496) 4.033ABCA1, APOB, STAP1
response to organic cyclic compound (GO:0014070) 3.073ABCA1, APOA2, GHR
response to nutrient levels (GO:0031667) 3.773ABCA1, PCSK9, GHR
organic substance biosynthetic process (GO:1901576) 1.343ABCA1, APOA2, APOB
protein modification process (GO:0036211) 1.793ABCA1, GHR, APOA2
plasma lipoprotein particle organization (GO:0071827) 6.233ABCA1, APOA2, APOB
response to external biotic stimulus (GO:0043207) 3.133ABCA1, APOB, STAP1
plasma lipoprotein particle clearance (GO:0034381) 6.783APOA2, APOB, LDLR
positive regulation of multicellular organismal process (GO:0051240) 2.493APOA2, EPHX2, GHR
negative regulation of multicellular organismal process (GO:0051241) 2.843PCSK9, APOA2, STAP1
triglyceride metabolic process (GO:0006641) 5.413PCSK9, APOA2, APOB
cellular component organization (GO:0016043) 1.243ABCA1, APOA2, APOB
negative regulation of catalytic activity (GO:0043086) 3.03ITIH4, APOA2, PPP1R17
interspecies interaction between organisms (GO:0044419) 3.083APOA2, APOB, LDLR
animal organ development (GO:0048513) 2.533PCSK9, GHR, APOA2
positive regulation of cellular protein metabolic process (GO:0032270) 2.493PCSK9, GHR, STAP1
cellular component organization or biogenesis (GO:0071840) 1.223ABCA1, APOA2, APOB
positive regulation of molecular function (GO:0044093) 2.233APOA2, GHR, STAP1
phospholipid transport (GO:0015914) 5.673ABCA1, APOA2, LDLR
cellular response to endogenous stimulus (GO:0071495) 3.333PCSK9, GHR, APOB
positive regulation of catalytic activity (GO:0043085) 2.43APOA2, GHR, STAP1
negative regulation of cellular metabolic process (GO:0031324) 2.013ITIH4, PCSK9, STAP1
response to cytokine (GO:0034097) 3.843ITIH4, GHR, APOB
positive regulation of phosphate metabolic process (GO:0045937) 2.783ABCA1, GHR, STAP1
positive regulation of transport (GO:0051050) 2.93ABCA1, PCSK9, STAP1
regulation of steroid metabolic process (GO:0019218) 5.423APOA2, APOB, EPHX2
biosynthetic process (GO:0009058) 1.323ABCA1, APOA2, APOB
cellular protein modification process (GO:0006464) 1.793ABCA1, APOA2, GHR
protein-lipid complex assembly (GO:0065005) 6.683ABCA1, APOA2, APOB
defense response (GO:0006952) 2.783ITIH4, APOA2, EPHX2
macromolecule modification (GO:0043412) 1.733ABCA1, APOA2, GHR
multi-organism cellular process (GO:0044764) 3.143APOA2, APOB, LDLR
inflammatory response (GO:0006954) 3.643ITIH4, APOA2, EPHX2
endocytosis (GO:0006897) 3.693APOB, LDLR, GHR
glycerolipid metabolic process (GO:0046486) 3.913PCSK9, APOA2, APOB
macromolecule catabolic process (GO:0009057) 3.03PCSK9, APOB, LDLR
multi-organism process (GO:0051704) 2.653APOA2, APOB, LDLR
regulation of hydrolase activity (GO:0051336) 2.533ITIH4, APOA2, PPP1R17
protein-lipid complex subunit organization (GO:0071825) 6.153ABCA1, APOA2, APOB
positive regulation of cellular biosynthetic process (GO:0031328) 2.33ABCA1, APOA2, LDLR
response to biotic stimulus (GO:0009607) 3.093ABCA1, APOB, STAP1
receptor-mediated endocytosis (GO:0006898) 4.313APOB, LDLR, GHR
cellular response to hormone stimulus (GO:0032870) 3.993PCSK9, GHR, APOB
regulation of gene expression (GO:0010468) 1.373APOB, EPHX2, STAP1
macromolecule biosynthetic process (GO:0009059) 1.613ABCA1, APOA2, APOB
response to molecule of bacterial origin (GO:0002237) 3.993ABCA1, APOB, STAP1
viral process (GO:0016032) 3.153APOA2, APOB, LDLR
organophosphate ester transport (GO:0015748) 5.333ABCA1, APOA2, LDLR
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.153APOA2, APOB, LDLR
positive regulation of phosphorus metabolic process (GO:0010562) 2.783ABCA1, GHR, STAP1
cholesterol efflux (GO:0033344) 6.473ABCA1, APOA2, APOB
negative regulation of response to stimulus (GO:0048585) 2.522APOA2, STAP1
positive regulation of response to stimulus (GO:0048584) 2.182GHR, STAP1
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242GHR, STAP1
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) 3.542GHR, STAP1
single-organism catabolic process (GO:0044712) 3.212APOA2, APOB
negative regulation of macromolecule metabolic process (GO:0010605) 2.012ITIH4, PCSK9
positive regulation of signal transduction (GO:0009967) 2.52GHR, STAP1
peptidyl-amino acid modification (GO:0018193) 2.982APOA2, GHR
positive regulation of lipid metabolic process (GO:0045834) 4.882APOA2, LDLR
diterpenoid metabolic process (GO:0016101) 5.172APOA2, APOB
macromolecule localization (GO:0033036) 2.342ABCA1, APOB
glycerolipid catabolic process (GO:0046503) 6.152APOA2, APOB
negative regulation of transport (GO:0051051) 3.62PCSK9, APOA2
macromolecular complex remodeling (GO:0034367) 6.552APOA2, APOB
protein-lipid complex remodeling (GO:0034368) 6.552APOA2, APOB
plasma lipoprotein particle remodeling (GO:0034369) 6.552APOA2, APOB
regulation of protein kinase activity (GO:0045859) 3.152GHR, STAP1
monocarboxylic acid metabolic process (GO:0032787) 3.572GHR, EPHX2
establishment of protein localization (GO:0045184) 2.532ABCA1, APOB
protein catabolic process (GO:0030163) 3.932PCSK9, APOB
oxoacid metabolic process (GO:0043436) 3.122GHR, EPHX2
response to peptide hormone (GO:0043434) 4.062PCSK9, GHR
system process (GO:0003008) 2.32LDLR, EPHX2
regulation of phosphorylation (GO:0042325) 2.52GHR, STAP1
positive regulation of phosphorylation (GO:0042327) 2.92GHR, STAP1
organonitrogen compound metabolic process (GO:1901564) 2.322ITIH4, GHR
organic acid metabolic process (GO:0006082) 3.012GHR, EPHX2
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622GHR, STAP1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352GHR, STAP1
response to organonitrogen compound (GO:0010243) 3.22PCSK9, GHR
regulation of cholesterol storage (GO:0010885) 7.162ABCA1, APOB
regulation of lipid storage (GO:0010883) 6.022ABCA1, APOB
organophosphate metabolic process (GO:0019637) 3.042PCSK9, APOA2
positive regulation of catabolic process (GO:0009896) 3.942PCSK9, APOA2
low-density lipoprotein particle remodeling (GO:0034374) 7.332APOA2, APOB
negative regulation of transporter activity (GO:0032410) 5.592PCSK9, APOA2
positive regulation of kinase activity (GO:0033674) 3.542GHR, STAP1
regulation of cholesterol metabolic process (GO:0090181) 6.642APOB, EPHX2
secretion by cell (GO:0032940) 3.592ABCA1, ITIH4
intracellular signal transduction (GO:0035556) 2.392PPP1R17, GHR
lipoprotein catabolic process (GO:0042159) 7.532APOB, LDLR
cellular lipid catabolic process (GO:0044242) 4.732APOA2, APOB
cellular macromolecule catabolic process (GO:0044265) 3.192PCSK9, APOB
positive regulation of transferase activity (GO:0051347) 3.312GHR, STAP1
negative regulation of hydrolase activity (GO:0051346) 3.742ITIH4, APOA2
regulation of kinase activity (GO:0043549) 3.072GHR, STAP1
lipid catabolic process (GO:0016042) 4.212APOA2, APOB
regulation of immune system process (GO:0002682) 2.52APOA2, STAP1
negative regulation of immune system process (GO:0002683) 3.852APOA2, STAP1
cellular response to molecule of bacterial origin (GO:0071219) 4.882ABCA1, STAP1
cellular response to biotic stimulus (GO:0071216) 4.762ABCA1, STAP1
(GO:0033700) 7.092ABCA1, APOA2
positive regulation of cellular component organization (GO:0051130) 2.682PCSK9, STAP1
regulation of developmental process (GO:0050793) 2.12GHR, STAP1
acute inflammatory response (GO:0002526) 5.482ITIH4, APOA2
regulation of neuron death (GO:1901214) 4.192PCSK9, GHR
regulation of intracellular signal transduction (GO:1902531) 2.312ABCA1, GHR
secretion (GO:0046903) 3.382ABCA1, ITIH4
regulation of lipid transport (GO:0032368) 5.212ABCA1, APOA2
low-density lipoprotein particle clearance (GO:0034383) 7.532APOB, LDLR
response to nitrogen compound (GO:1901698) 3.122PCSK9, GHR
positive regulation of protein modification process (GO:0031401) 2.72GHR, STAP1
regulation of transferase activity (GO:0051338) 2.882GHR, STAP1
response to alcohol (GO:0097305) 4.582ABCA1, GHR
fatty acid metabolic process (GO:0006631) 4.032GHR, EPHX2
negative regulation of cellular component organization (GO:0051129) 3.352APOA2, STAP1
reverse cholesterol transport (GO:0043691) 6.842ABCA1, APOA2
positive regulation of signaling (GO:0023056) 2.412GHR, STAP1
negative regulation of signaling (GO:0023057) 2.652PCSK9, STAP1
positive regulation of cell communication (GO:0010647) 2.412GHR, STAP1
cellular response to peptide hormone stimulus (GO:0071375) 4.632PCSK9, GHR
regulation of system process (GO:0044057) 3.532APOA2, EPHX2
regulation of cholesterol transport (GO:0032374) 6.092ABCA1, APOA2
regulation of sterol transport (GO:0032371) 6.092ABCA1, APOA2
regulation of transporter activity (GO:0032409) 4.452PCSK9, APOA2
regulation of protein modification process (GO:0031399) 2.322GHR, STAP1
acylglycerol catabolic process (GO:0046464) 6.472APOA2, APOB
neutral lipid catabolic process (GO:0046461) 6.472APOA2, APOB
phospholipid metabolic process (GO:0006644) 3.882PCSK9, APOA2
cellular response to nitrogen compound (GO:1901699) 3.792PCSK9, GHR
terpenoid metabolic process (GO:0006721) 5.072APOA2, APOB
isoprenoid metabolic process (GO:0006720) 4.892APOA2, APOB
cellular response to lipid (GO:0071396) 3.962ABCA1, STAP1
regulation of vesicle-mediated transport (GO:0060627) 3.632PCSK9, STAP1
positive regulation of cell differentiation (GO:0045597) 3.012GHR, APOB
negative regulation of cell differentiation (GO:0045596) 3.332ABCA1, STAP1
cellular protein catabolic process (GO:0044257) 6.512PCSK9, APOB
regulation of immune response (GO:0050776) 2.982APOA2, STAP1
vacuolar transport (GO:0007034) 4.182ABCA1, PCSK9
response to drug (GO:0042493) 3.712ABCA1, APOA2
system development (GO:0048731) 2.922PPP1R17, APOB
positive regulation of protein kinase activity (GO:0045860) 3.612GHR, STAP1
(GO:0034380) 7.652ABCA1, APOA2
response to steroid hormone (GO:0048545) 4.242APOA2, GHR
response to glucocorticoid (GO:0051384) 4.632GHR, APOA2
cellular response to lipopolysaccharide (GO:0071222) 4.942ABCA1, STAP1
carboxylic acid metabolic process (GO:0019752) 3.122GHR, EPHX2
regulation of lipid biosynthetic process (GO:0046890) 4.872APOB, LDLR
cellular response to insulin stimulus (GO:0032869) 5.292PCSK9, GHR
response to insulin (GO:0032868) 4.722PCSK9, GHR
regulation of cell death (GO:0010941) 2.432PCSK9, GHR
retinoid metabolic process (GO:0001523) 5.252APOA2, APOB
cellular response to organonitrogen compound (GO:0071417) 3.872PCSK9, GHR
response to corticosteroid (GO:0031960) 4.562GHR, APOA2
regulation of macrophage derived foam cell differentiation (GO:0010743) 6.42ABCA1, APOB
regulation of nitrogen compound metabolic process (GO:0051171) 1.362ABCA1, LDLR
regulation of endocytosis (GO:0030100) 4.422PCSK9, STAP1
regulation of protein phosphorylation (GO:0001932) 2.572GHR, STAP1
response to carbohydrate (GO:0009743) 4.622APOA2, APOB
response to peptide (GO:1901652) 3.942PCSK9, GHR
cellular response to peptide (GO:1901653) 4.522PCSK9, GHR
positive regulation of endocytosis (GO:0045807) 4.982PCSK9, STAP1
receptor metabolic process (GO:0043112) 5.322PCSK9, GHR
positive regulation of protein phosphorylation (GO:0001934) 2.952GHR, STAP1

NET-GE enrichment

Term New enriched termICP valueGenes
plasma lipoprotein particle assembly (GO:0034377) -6.840.0ABCA1, APOA2, APOB
low-density lipoprotein particle remodeling (GO:0034374) -7.330.01APOA2, APOB
regulation of low-density lipoprotein particle receptor catabolic process (GO:0032803) NEW8.120.007PCSK9, LDLR
sterol transport (GO:0015918) -5.840.0APOA2, ABCA1, APOB, LDLR
organic hydroxy compound transport (GO:0015850) -4.960.0ABCA1, APOA2, PCSK9, APOB, LDLR
acylglycerol metabolic process (GO:0006639) -5.270.006APOA2, PCSK9, APOB, LDLR
neutral lipid metabolic process (GO:0006638) -5.260.011APOA2, PCSK9, APOB, LDLR
reverse cholesterol transport (GO:0043691) -6.840.0ABCA1, APOA2, APOB
homeostatic process (GO:0042592) -2.610.005PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
sterol metabolic process (GO:0016125) -4.920.0ABCA1, APOA2, PCSK9, APOB, LDLR
lipoprotein metabolic process (GO:0042157) -5.820.0ABCA1, APOA2, PCSK9, APOB, LDLR
lipoprotein catabolic process (GO:0042159) -7.530.004APOB, LDLR
sterol homeostasis (GO:0055092) -5.60.0PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
protein-lipid complex subunit organization (GO:0071825) -6.150.013ABCA1, APOA2, APOB
plasma lipoprotein particle organization (GO:0071827) -6.230.0ABCA1, APOA2, APOB
plasma lipoprotein particle remodeling (GO:0034369) -6.550.048ABCA1, APOA2, APOB
regulation of cholesterol transport (GO:0032374) -6.090.007ABCA1, APOA2, APOB
triglyceride metabolic process (GO:0006641) -5.410.004APOA2, PCSK9, APOB, LDLR
regulation of sterol transport (GO:0032371) -6.090.007ABCA1, APOA2, APOB
retinoid metabolic process (GO:0001523) -5.250.007APOA2, APOB, LDLR
terpenoid metabolic process (GO:0006721) -5.070.011APOA2, APOB, LDLR
positive regulation of lipid metabolic process (GO:0045834) -4.880.014APOA2, ABCA1, APOB, LDLR
protein-lipid complex assembly (GO:0065005) -6.680.001ABCA1, APOA2, APOB
isoprenoid metabolic process (GO:0006720) -4.890.019APOA2, APOB, LDLR
diterpenoid metabolic process (GO:0016101) -5.170.008APOA2, APOB, LDLR
acylglycerol catabolic process (GO:0046464) -6.470.04APOA2, APOB
macromolecular complex remodeling (GO:0034367) -6.550.048ABCA1, APOA2, APOB
phospholipid transport (GO:0015914) -5.670.0APOA2, ABCA1, APOB, LDLR
neutral lipid catabolic process (GO:0046461) -6.470.04APOA2, APOB
protein oxidation (GO:0018158) NEW7.940.026ABCA1, APOA2
detection of light stimulus (GO:0009583) NEW5.670.023APOA2, APOB, LDLR
detection of visible light (GO:0009584) NEW6.230.015APOA2, APOB, LDLR
lipid metabolic process (GO:0006629) -2.680.0GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
regulation of lipid metabolic process (GO:0019216) -4.080.028APOA2, LDLR, ABCA1, APOB, EPHX2
protein-lipid complex remodeling (GO:0034368) -6.550.048ABCA1, APOA2, APOB
regulation of steroid metabolic process (GO:0019218) -5.420.006APOA2, EPHX2, APOB, LDLR
organic anion transport (GO:0015711) NEW4.070.036ABCA1, APOA2, PCSK9, APOB, LDLR
phototransduction, visible light (GO:0007603) NEW7.530.009APOA2, APOB, LDLR
phototransduction (GO:0007602) NEW5.990.017APOA2, PCSK9, APOB, LDLR
lipid homeostasis (GO:0055088) -5.00.0PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
regulation of lipid transport (GO:0032368) -5.210.007APOA2, ABCA1, APOB, LDLR
inflammatory response (GO:0006954) -3.640.02ITIH4, APOA2, LDLR, EPHX2, ABCA1, APOB
cholesterol homeostasis (GO:0042632) -5.60.0PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
cellular lipid metabolic process (GO:0044255) -2.920.0GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
regulation of cholesterol metabolic process (GO:0090181) -6.640.036APOB, EPHX2
lipid transport (GO:0006869) -4.240.002APOA2, ABCA1, APOB, LDLR
regulation of receptor catabolic process (GO:2000644) NEW7.650.015PCSK9, LDLR
steroid metabolic process (GO:0008202) -4.320.0ABCA1, APOA2, PCSK9, APOB, LDLR
cholesterol metabolic process (GO:0008203) -5.030.0ABCA1, APOA2, PCSK9, APOB, LDLR
receptor metabolic process (GO:0043112) -5.320.003PCSK9, APOB, LDLR, GHR
regulation of macrophage derived foam cell differentiation (GO:0010743) -6.40.007ABCA1, APOB, LDLR
cholesterol transport (GO:0030301) -5.880.0APOA2, ABCA1, APOB, LDLR
negative regulation of lipid transport (GO:0032369) NEW6.430.003ABCA1, APOA2, APOB
low-density lipoprotein particle clearance (GO:0034383) -7.530.005APOB, LDLR
high-density lipoprotein particle assembly (GO:0034380) -7.650.003ABCA1, APOA2
plasma lipoprotein particle clearance (GO:0034381) -6.780.0APOA2, APOB, LDLR
chemical homeostasis (GO:0048878) -2.970.001PCSK9, APOA2, LDLR, EPHX2, ABCA1, APOB
alcohol metabolic process (GO:0006066) -4.20.0ABCA1, APOA2, PCSK9, APOB, LDLR
positive regulation of cholesterol storage (GO:0010886) NEW7.780.018APOB, LDLR
regulation of cholesterol storage (GO:0010885) -7.160.0ABCA1, APOB, LDLR
cholesterol efflux (GO:0033344) -6.470.001ABCA1, APOA2, APOB
regulation of lipid storage (GO:0010883) -6.020.007ABCA1, APOB, LDLR
organophosphate ester transport (GO:0015748) -5.330.005APOA2, ABCA1, APOB, LDLR
phospholipid efflux (GO:0033700) -7.090.035ABCA1, APOA2
triglyceride-rich lipoprotein particle remodeling (GO:0034370) NEW7.530.026APOA2, APOB
organic hydroxy compound metabolic process (GO:1901615) -3.840.001GHR, PCSK9, APOA2, LDLR, ABCA1, APOB
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1110ITIH4, GHR, STAP1, PCSK9, APOA2, LDLR, PPP1R17, EPHX2, ABCA1, APOB
intracellular part (GO:0044424) 0.289ITIH4, GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
cytoplasmic part (GO:0044444) 0.829ITIH4, GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
membrane-bounded organelle (GO:0043227) 0.479ITIH4, GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
organelle (GO:0043226) 0.49ITIH4, GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
intracellular organelle (GO:0043229) 0.518GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
intracellular membrane-bounded organelle (GO:0043231) 0.68GHR, STAP1, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
extracellular region part (GO:0044421) 1.578ITIH4, GHR, PCSK9, LDLR, APOA2, EPHX2, ABCA1, APOB
macromolecular complex (GO:0032991) 1.357STAP1, GHR, PCSK9, LDLR, APOA2, ABCA1, APOB
cytoplasm (GO:0005737) 1.016ITIH4, GHR, STAP1, PCSK9, EPHX2, APOB
membrane (GO:0016020) 0.686ITIH4, GHR, PCSK9, LDLR, ABCA1, APOB
vesicle (GO:0031982) 1.646ITIH4, PCSK9, APOA2, EPHX2, ABCA1, APOB
plasma membrane (GO:0005886) 1.396ITIH4, GHR, PCSK9, LDLR, ABCA1, APOB
membrane-bounded vesicle (GO:0031988) 1.716ITIH4, PCSK9, APOA2, EPHX2, ABCA1, APOB
intracellular organelle part (GO:0044446) 0.815ABCA1, APOA2, ITIH4, APOB, LDLR
membrane part (GO:0044425) 0.955ABCA1, PCSK9, APOB, LDLR, GHR
extracellular region (GO:0005576) 2.185ITIH4, APOA2, PCSK9, GHR, APOB
organelle part (GO:0044422) 0.795ABCA1, APOA2, ITIH4, APOB, LDLR
protein complex (GO:0043234) 1.514PCSK9, STAP1, LDLR, GHR
Golgi apparatus (GO:0005794) 2.74ABCA1, PCSK9, APOB, LDLR
extracellular organelle (GO:0043230) 1.894APOA2, ITIH4, APOB, EPHX2
plasma lipoprotein particle (GO:0034358) 6.164APOA2, ABCA1, APOB, LDLR
protein-lipid complex (GO:0032994) 6.114APOA2, ABCA1, APOB, LDLR
vacuole (GO:0005773) 2.924APOA2, PCSK9, APOB, LDLR
extracellular exosome (GO:0070062) 1.894APOA2, ITIH4, APOB, EPHX2
cell surface (GO:0009986) 3.444ABCA1, PCSK9, GHR, LDLR
early endosome (GO:0005769) 4.344APOA2, PCSK9, APOB, LDLR
lipoprotein particle (GO:1990777) 6.164APOA2, ABCA1, APOB, LDLR
extracellular vesicle (GO:1903561) 1.894APOA2, ITIH4, APOB, EPHX2
plasma membrane part (GO:0044459) 1.954ABCA1, PCSK9, GHR, LDLR
endosome (GO:0005768) 3.254APOA2, PCSK9, APOB, LDLR
extracellular space (GO:0005615) 2.634APOA2, PCSK9, GHR, APOB
organelle lumen (GO:0043233) 3.053ITIH4, APOA2, APOB
integral component of membrane (GO:0016021) 1.143ABCA1, GHR, LDLR
membrane-enclosed lumen (GO:0031974) 3.053ITIH4, APOA2, APOB
cytoplasmic vesicle part (GO:0044433) 3.413ITIH4, APOB, LDLR
endoplasmic reticulum part (GO:0044432) 2.733ABCA1, APOA2, APOB
intracellular organelle lumen (GO:0070013) 3.053ITIH4, APOA2, APOB
integral component of plasma membrane (GO:0005887) 2.573ABCA1, GHR, LDLR
intrinsic component of plasma membrane (GO:0031226) 2.533ABCA1, GHR, LDLR
cytosol (GO:0005829) 1.683APOA2, APOB, EPHX2
intrinsic component of membrane (GO:0031224) 1.133ABCA1, GHR, LDLR
external side of plasma membrane (GO:0009897) 4.462ABCA1, LDLR
lytic vacuole (GO:0000323) 3.892PCSK9, LDLR
endoplasmic reticulum (GO:0005783) 2.562PCSK9, APOB
side of membrane (GO:0098552) 4.222ABCA1, LDLR
endoplasmic reticulum lumen (GO:0005788) 4.52APOA2, APOB
endoplasmic reticulum membrane (GO:0005789) 2.952ABCA1, APOB
mitochondrion (GO:0005739) 2.422GHR, STAP1
cytoplasmic membrane-bounded vesicle lumen (GO:0060205) 5.192ITIH4, APOB
intracellular (GO:0005622) 2.372PPP1R17, GHR
endosome membrane (GO:0010008) 3.832APOB, LDLR
clathrin-coated vesicle membrane (GO:0030665) 5.62APOB, LDLR
chylomicron (GO:0042627) 7.242APOA2, APOB
vesicle lumen (GO:0031983) 5.172ITIH4, APOB
organelle membrane (GO:0031090) 1.972APOB, LDLR
coated vesicle membrane (GO:0030662) 5.02APOB, LDLR
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122ABCA1, PCSK9
cytoplasmic vesicle (GO:0031410) 2.872ABCA1, PCSK9
nucleus (GO:0005634) 1.072GHR, STAP1
late endosome (GO:0005770) 4.852PCSK9, LDLR
clathrin-coated endocytic vesicle membrane (GO:0030669) 6.092APOB, LDLR
blood microparticle (GO:0072562) 4.882ITIH4, APOA2
vacuolar membrane (GO:0005774) 3.452APOB, LDLR
neuron part (GO:0097458) 2.642GHR, APOB
vacuolar part (GO:0044437) 3.262APOB, LDLR
perinuclear region of cytoplasm (GO:0048471) 3.352ABCA1, PCSK9
neuronal cell body (GO:0043025) 3.92GHR, APOB
very-low-density lipoprotein particle (GO:0034361) 6.812APOA2, APOB
low-density lipoprotein particle (GO:0034362) 7.162APOB, LDLR
high-density lipoprotein particle (GO:0034364) 6.542ABCA1, APOA2
bounding membrane of organelle (GO:0098588) 2.392APOB, LDLR
membrane region (GO:0098589) 3.952ABCA1, LDLR
cell body (GO:0044297) 3.742GHR, APOB
cytoplasmic vesicle membrane (GO:0030659) 3.672APOB, LDLR
endocytic vesicle membrane (GO:0030666) 4.822APOB, LDLR
intracellular vesicle (GO:0097708) 2.862ABCA1, PCSK9
vesicle membrane (GO:0012506) 3.632APOB, LDLR
PCSK9-LDLR complex (GO:1990666) 9.112PCSK9, LDLR
receptor complex (GO:0043235) 4.012GHR, LDLR
triglyceride-rich lipoprotein particle (GO:0034385) 6.812APOA2, APOB
lysosome (GO:0005764) 3.892PCSK9, LDLR
endosomal part (GO:0044440) 3.732APOB, LDLR
whole membrane (GO:0098805) 2.852APOB, LDLR

NET-GE enrichment

Term New enriched termICP valueGenes
protein-lipid complex (GO:0032994) -6.110.001APOA2, APOB, LDLR
low-density lipoprotein particle (GO:0034362) -7.160.009APOB, LDLR
chylomicron (GO:0042627) -7.240.0APOA2, APOB, LDLR
high-density lipoprotein particle (GO:0034364) -6.540.0APOA2, APOB, LDLR
plasma lipoprotein particle (GO:0034358) -6.160.0APOA2, APOB, LDLR
very-low-density lipoprotein particle (GO:0034361) -6.810.005APOA2, APOB, LDLR
endosome (GO:0005768) -3.250.029ABCA1, APOA2, PCSK9, APOB, LDLR
coated vesicle membrane (GO:0030662) -5.00.026PCSK9, APOB, LDLR
clathrin-coated endocytic vesicle membrane (GO:0030669) -6.090.02APOB, LDLR
blood microparticle (GO:0072562) -4.880.005ITIH4, PCSK9, APOA2, APOB
triglyceride-rich lipoprotein particle (GO:0034385) -6.810.005APOA2, APOB, LDLR
extracellular region (GO:0005576) -2.180.049ITIH4, GHR, PCSK9, LDLR, APOA2, ABCA1, APOB
transport vesicle (GO:0030133) NEW4.30.032PCSK9, APOB, LDLR
extrinsic component of external side of plasma membrane (GO:0031232) NEW7.720.003PCSK9, APOB
coated vesicle (GO:0030135) NEW4.940.007PCSK9, APOB, LDLR
early endosome (GO:0005769) -4.340.0ABCA1, APOA2, PCSK9, APOB, LDLR