Gene table of LIG4 : DNA ligase 4

Gene-disease associations table

Disease ID	Disease name	Source of annotation with LIG4	OMIM link	Number of associated genes	genes
254500	MYELOMA, MULTIPLE	OMIM	link to OMIM	2	LIG4, CCND1
606593	LIG4 SYNDROME	OMIM, HUMSAVAR	link to OMIM	1	LIG4

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Non-homologous end-joining	hsa03450	8.96

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Infectious disease	R-HSA-5663205	4.47
HIV Life Cycle	R-HSA-162587	5.89
HIV Infection	R-HSA-162906	5.22
DNA Repair	R-HSA-73894	5.8
Nonhomologous End-Joining (NHEJ)	R-HSA-73889	10.18
2-LTR circle formation	R-HSA-164843	10.18
Early Phase of HIV Life Cycle	R-HSA-162594	9.4
Double-Strand Break Repair	R-HSA-73890	8.46
Integration of provirus	R-HSA-162592	9.81
Disease	R-HSA-1643685	3.33

Associated GO terms for Molecular function

GO term	GO ID	GO IC
protein C-terminus binding	GO:0008022	4.5
purine ribonucleoside triphosphate binding	GO:0035639	2.22
DNA binding	GO:0003677	1.92
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
ligase activity, forming phosphoric ester bonds	GO:0016886	7.44
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
ion binding	GO:0043167	1.36
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
ligase activity	GO:0016874	3.72
DNA ligase activity	GO:0003909	7.79
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
DNA ligase (ATP) activity	GO:0003910	7.95