Disease table of MYELOMA, MULTIPLE OMIM ID: 254500

Gene-disease associations table

GeneAssociated with MYELOMA, MULTIPLE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CCND1OMIMHGNC link11q13.33193300, 254500, 114500
LIG4OMIMHGNC link13q33.32606593, 254500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CCND1YES62POU4F2, RELA, E2F4, MYBL2, AR, MECP2, PML, BHLHE41, EZH2, ATF2, PGR, JUND, FOS, PAX5, STAT5B, RUNX3, RNF14, POU2F1, EGR1, EP300, KLF4, HOXA1, STAT5A, CTNNB1, BRCA1, ESR1, SIRT1, VHL, SP1, KLF6, LEF1, HDAC1, KDM4B, NKX3-1, SOX2, HOXB7, JUN, ZNF24, TP53, NANOG, E2F8, NELFCD, NFKB1, E2F1, FHL2, STAT3, TCF4, BTG2, NR3C1, SP4, TSC22D3, SNIP1, HEXIM1, ING4, LIN28A, HIF1A, SMARCA4, SP3, MYC, PPARG, KLF5, SOX60
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
CCND1LIG4No1PSMA6

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.052CCND1, LIG4
binding (GO:0005488) 0.182CCND1, LIG4
protein binding (GO:0005515) 0.462CCND1, LIG4
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of cell proliferation (GO:0042127) 2.412CCND1, LIG4
response to abiotic stimulus (GO:0009628) 2.82CCND1, LIG4
regulation of multicellular organismal process (GO:0051239) 1.872CCND1, LIG4
response to radiation (GO:0009314) 3.692CCND1, LIG4
cell differentiation (GO:0030154) 2.142CCND1, LIG4
cellular macromolecule biosynthetic process (GO:0034645) 1.662CCND1, LIG4
metabolic process (GO:0008152) 0.582CCND1, LIG4
cellular biosynthetic process (GO:0044249) 1.372CCND1, LIG4
cellular nitrogen compound metabolic process (GO:0034641) 1.222CCND1, LIG4
nitrogen compound metabolic process (GO:0006807) 1.132CCND1, LIG4
organic cyclic compound metabolic process (GO:1901360) 1.262CCND1, LIG4
cellular response to chemical stimulus (GO:0070887) 2.572CCND1, LIG4
regulation of cell differentiation (GO:0045595) 2.422CCND1, LIG4
organic substance biosynthetic process (GO:1901576) 1.342CCND1, LIG4
organic cyclic compound biosynthetic process (GO:1901362) 1.662CCND1, LIG4
regulation of biological process (GO:0050789) 0.452CCND1, LIG4
single-organism process (GO:0044699) 0.482CCND1, LIG4
nucleobase-containing compound metabolic process (GO:0006139) 1.352CCND1, LIG4
cellular response to stimulus (GO:0051716) 1.972CCND1, LIG4
response to ionizing radiation (GO:0010212) 4.742CCND1, LIG4
cellular macromolecule metabolic process (GO:0044260) 0.932CCND1, LIG4
cellular developmental process (GO:0048869) 1.822CCND1, LIG4
positive regulation of multicellular organismal process (GO:0051240) 2.492CCND1, LIG4
organic substance metabolic process (GO:0071704) 0.632CCND1, LIG4
biological regulation (GO:0065007) 0.392CCND1, LIG4
cell division (GO:0051301) 3.682CCND1, LIG4
positive regulation of biological process (GO:0048518) 1.22CCND1, LIG4
negative regulation of biological process (GO:0048519) 1.332CCND1, LIG4
heterocycle biosynthetic process (GO:0018130) 1.72CCND1, LIG4
positive regulation of cell proliferation (GO:0008284) 3.012CCND1, LIG4
multicellular organismal process (GO:0032501) 1.452CCND1, LIG4
cell proliferation (GO:0008283) 3.232CCND1, LIG4
regulation of developmental process (GO:0050793) 2.12CCND1, LIG4
cellular process (GO:0009987) 0.262CCND1, LIG4
cellular aromatic compound metabolic process (GO:0006725) 1.32CCND1, LIG4
regulation of cellular process (GO:0050794) 0.52CCND1, LIG4
cellular response to DNA damage stimulus (GO:0006974) 3.172CCND1, LIG4
biosynthetic process (GO:0009058) 1.322CCND1, LIG4
macromolecule biosynthetic process (GO:0009059) 1.612CCND1, LIG4
single-organism cellular process (GO:0044763) 0.652CCND1, LIG4
response to metal ion (GO:0010038) 3.912CCND1, LIG4
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722CCND1, LIG4
response to chemical (GO:0042221) 1.982CCND1, LIG4
response to inorganic substance (GO:0010035) 3.562CCND1, LIG4
primary metabolic process (GO:0044238) 0.692CCND1, LIG4
response to X-ray (GO:0010165) 6.332CCND1, LIG4
heterocycle metabolic process (GO:0046483) 1.312CCND1, LIG4
RNA metabolic process (GO:0016070) 1.592CCND1, LIG4
single-organism developmental process (GO:0044767) 1.492CCND1, LIG4
cell cycle (GO:0007049) 3.142CCND1, LIG4
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592CCND1, LIG4
single-multicellular organism process (GO:0044707) 1.782CCND1, LIG4
positive regulation of developmental process (GO:0051094) 2.772CCND1, LIG4
nucleic acid metabolic process (GO:0090304) 1.462CCND1, LIG4
response to stimulus (GO:0050896) 1.222CCND1, LIG4
anatomical structure development (GO:0048856) 1.582CCND1, LIG4
response to stress (GO:0006950) 1.82CCND1, LIG4
cellular metabolic process (GO:0044237) 0.692CCND1, LIG4
macromolecule metabolic process (GO:0043170) 0.832CCND1, LIG4
developmental process (GO:0032502) 1.362CCND1, LIG4
regulation of multicellular organismal development (GO:2000026) 2.312CCND1, LIG4
cellular response to stress (GO:0033554) 2.512CCND1, LIG4
aromatic compound biosynthetic process (GO:0019438) 1.72CCND1, LIG4
negative regulation of cellular process (GO:0048523) 1.412CCND1, LIG4
positive regulation of cellular process (GO:0048522) 1.32CCND1, LIG4

NET-GE enrichment

Term New enriched termICP valueGenes
telomere maintenance (GO:0000723) NEW5.370.047CCND1, LIG4
response to X-ray (GO:0010165) -6.330.007CCND1, LIG4
response to ionizing radiation (GO:0010212) -4.740.017CCND1, LIG4
cell division (GO:0051301) -3.680.017CCND1, LIG4
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.012CCND1, LIG4
protein complex (GO:0043234) 1.512CCND1, LIG4
macromolecular complex (GO:0032991) 1.352CCND1, LIG4
intracellular membrane-bounded organelle (GO:0043231) 0.62CCND1, LIG4
nucleus (GO:0005634) 1.072CCND1, LIG4
membrane (GO:0016020) 0.682CCND1, LIG4
cell part (GO:0044464) 0.112CCND1, LIG4
intracellular organelle part (GO:0044446) 0.812CCND1, LIG4
nucleoplasm (GO:0005654) 1.892CCND1, LIG4
intracellular organelle (GO:0043229) 0.512CCND1, LIG4
nuclear part (GO:0044428) 1.552CCND1, LIG4
organelle part (GO:0044422) 0.792CCND1, LIG4
intracellular part (GO:0044424) 0.282CCND1, LIG4
membrane-bounded organelle (GO:0043227) 0.472CCND1, LIG4
organelle (GO:0043226) 0.42CCND1, LIG4
cell junction (GO:0030054) 2.752CCND1, LIG4