Gene table of MAP2K2 : mitogen-activated protein kinase kinase 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with MAP2K2	OMIM link	Number of associated genes	genes
PS115150	CARDIOFACIOCUTANEOUS SYNDROME	ClinVar, OMIM, HUMSAVAR	link to OMIM	4	KRAS, BRAF, MAP2K1, MAP2K2

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Annotation of the gene MAP2K2

Associated genes in ENSEMBL

ENSG00000126934

Associated proteins - SwissProt Accession ID

P36507

Associated PDB IDs

Cytogenetic Band

19p13.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Melanoma	hsa05218	6.56
Bladder cancer	hsa05219	7.38
cGMP-PKG signaling pathway	hsa04022	5.32
Natural killer cell mediated cytotoxicity	hsa04650	5.53
Chronic myeloid leukemia	hsa05220	6.48
Thyroid cancer	hsa05216	7.48
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
cAMP signaling pathway	hsa04024	5.05
Prostate cancer	hsa05215	6.11
Long-term potentiation	hsa04720	6.64
Neurotrophin signaling pathway	hsa04722	5.78
Central carbon metabolism in cancer	hsa05230	6.7
Choline metabolism in cancer	hsa05231	6.09
FoxO signaling pathway	hsa04068	5.63
HIF-1 signaling pathway	hsa04066	5.9
Oxytocin signaling pathway	hsa04921	5.4
ErbB signaling pathway	hsa04012	6.15
Insulin signaling pathway	hsa04910	5.55
Prion diseases	hsa05020	7.48
Endometrial cancer	hsa05213	6.81
Influenza A	hsa05164	5.21
PI3K-Akt signaling pathway	hsa04151	4.21
Hepatitis B	hsa05161	5.52
Vascular smooth muscle contraction	hsa04270	5.74
Renal cell carcinoma	hsa05211	6.6
Gap junction	hsa04540	6.24
VEGF signaling pathway	hsa04370	6.77
Proteoglycans in cancer	hsa05205	5.02
Estrogen signaling pathway	hsa04915	6.11
MicroRNAs in cancer	hsa05206	5.38
Toll-like receptor signaling pathway	hsa04620	6.0
Pathways in cancer	hsa05200	3.98
GnRH signaling pathway	hsa04912	6.18
B cell receptor signaling pathway	hsa04662	6.52
Ras signaling pathway	hsa04014	4.9
Melanogenesis	hsa04916	5.97
Glioma	hsa05214	6.66
Acute myeloid leukemia	hsa05221	6.74
MAPK signaling pathway	hsa04010	4.63
Thyroid hormone signaling pathway	hsa04919	5.82
Long-term depression	hsa04730	6.74
Regulation of actin cytoskeleton	hsa04810	4.9
T cell receptor signaling pathway	hsa04660	6.01
Non-small cell lung cancer	hsa05223	6.88
Rap1 signaling pathway	hsa04015	4.97
Fc epsilon RI signaling pathway	hsa04664	6.6
Prolactin signaling pathway	hsa04917	6.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signal transduction by L1	R-HSA-445144	8.59
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26
NCAM signaling for neurite out-growth	R-HSA-375165	4.9
Signaling by Interleukins	R-HSA-449147	4.71
Signaling by Leptin	R-HSA-2586552	5.1
Frs2-mediated activation	R-HSA-170968	5.12
MAP2K and MAPK activation	R-HSA-5674135	7.66
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
IGF1R signaling cascade	R-HSA-2428924	4.85
Signaling by FGFR3	R-HSA-5654741	4.69
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85
Signaling by ERBB4	R-HSA-1236394	4.7
Innate Immune System	R-HSA-168249	3.17
IRS-mediated signalling	R-HSA-112399	4.87
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
RAF activation	R-HSA-5673000	8.34
RAF/MAP kinase cascade	R-HSA-5673001	5.15
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
MAPK family signaling cascades	R-HSA-5683057	4.89
Signalling by NGF	R-HSA-166520	4.23
Signaling by VEGF	R-HSA-194138	4.66
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12
Developmental Biology	R-HSA-1266738	3.48
FCERI mediated MAPK activation	R-HSA-2871796	4.32
Signaling by EGFR	R-HSA-177929	4.59
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14
SOS-mediated signalling	R-HSA-112412	5.15
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14
Disease	R-HSA-1643685	3.33
Signaling by Insulin receptor	R-HSA-74752	4.73
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Insulin receptor signalling cascade	R-HSA-74751	4.85
Signaling by FGFR4	R-HSA-5654743	4.69
RAF-independent MAPK1/3 activation	R-HSA-112409	8.46
Infectious disease	R-HSA-5663205	4.47
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15
Interleukin receptor SHC signaling	R-HSA-912526	5.09
L1CAM interactions	R-HSA-373760	6.19
Signaling by FGFR	R-HSA-190236	4.67
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
Immune System	R-HSA-168256	2.37
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14
Signaling by SCF-KIT	R-HSA-1433557	4.73
Interleukin-2 signaling	R-HSA-451927	5.05
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15
Signaling by ERBB2	R-HSA-1227986	4.66
Signalling to RAS	R-HSA-167044	5.08
DAP12 signaling	R-HSA-2424491	4.64
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99
Negative feedback regulation of MAPK pathway	R-HSA-5674499	10.4
Uptake and actions of bacterial toxins	R-HSA-5339562	8.28
Signaling by FGFR1	R-HSA-5654736	4.69
SHC1 events in EGFR signaling	R-HSA-180336	5.15
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14
Prolonged ERK activation events	R-HSA-169893	5.11
Negative regulation of MAPK pathway	R-HSA-5675221	7.66
Uptake and function of anthrax toxins	R-HSA-5210891	9.66
Signaling by GPCR	R-HSA-372790	2.68
Signaling by FGFR2	R-HSA-5654738	4.68
GRB2 events in EGFR signaling	R-HSA-179812	5.15
Signalling to ERKs	R-HSA-187687	5.04
ARMS-mediated activation	R-HSA-170984	5.12
MAPK1 (ERK2) activation	R-HSA-112411	9.81
DAP12 interactions	R-HSA-2172127	4.56
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15
Signaling by PDGF	R-HSA-186797	4.53
Axon guidance	R-HSA-422475	3.93
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07
Signal Transduction	R-HSA-162582	1.78
Downstream signal transduction	R-HSA-186763	4.65

Associated GO terms for Molecular function

GO term	GO ID	GO IC
binding	GO:0005488	0.18
kinase regulator activity	GO:0019207	4.5
purine ribonucleoside triphosphate binding	GO:0035639	2.22
kinase activator activity	GO:0019209	5.58
protein complex scaffold	GO:0032947	5.5
signal transducer activity	GO:0004871	2.28
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
molecular function regulator	GO:0098772	2.51
receptor signaling protein activity	GO:0005057	4.76
ion binding	GO:0043167	1.36
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
protein serine/threonine/tyrosine kinase activity	GO:0004712	6.07
protein tyrosine kinase activity	GO:0004713	4.54
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
structural molecule activity	GO:0005198	3.1
protein kinase regulator activity	GO:0019887	4.6
enzyme regulator activity	GO:0030234	2.85
kinase activity	GO:0016301	2.93
nucleoside phosphate binding	GO:1901265	1.96
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
PDZ domain binding	GO:0030165	5.22
protein domain specific binding	GO:0019904	3.32
protein kinase activator activity	GO:0030295	5.68
protein serine/threonine kinase activator activity	GO:0043539	6.91
adenyl ribonucleotide binding	GO:0032559	2.41
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
receptor signaling protein serine/threonine kinase activity	GO:0004702	5.23
purine ribonucleoside binding	GO:0032550	2.22
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
scaffold protein binding	GO:0097110	5.93
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
MAP kinase kinase activity	GO:0004708	7.25
ribonucleotide binding	GO:0032553	2.19
enzyme activator activity	GO:0008047	3.56