Disease ID | Disease name | Source of annotation with MAP2K2 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS115150 | CARDIOFACIOCUTANEOUS SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 4 | KRAS, BRAF, MAP2K1, MAP2K2 |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Melanoma | hsa05218 | 6.56 |
Bladder cancer | hsa05219 | 7.38 |
cGMP-PKG signaling pathway | hsa04022 | 5.32 |
Natural killer cell mediated cytotoxicity | hsa04650 | 5.53 |
Chronic myeloid leukemia | hsa05220 | 6.48 |
Thyroid cancer | hsa05216 | 7.48 |
Signaling pathways regulating pluripotency of stem cells | hsa04550 | 5.6 |
cAMP signaling pathway | hsa04024 | 5.05 |
Prostate cancer | hsa05215 | 6.11 |
Long-term potentiation | hsa04720 | 6.64 |
Neurotrophin signaling pathway | hsa04722 | 5.78 |
Central carbon metabolism in cancer | hsa05230 | 6.7 |
Choline metabolism in cancer | hsa05231 | 6.09 |
FoxO signaling pathway | hsa04068 | 5.63 |
HIF-1 signaling pathway | hsa04066 | 5.9 |
Oxytocin signaling pathway | hsa04921 | 5.4 |
ErbB signaling pathway | hsa04012 | 6.15 |
Insulin signaling pathway | hsa04910 | 5.55 |
Prion diseases | hsa05020 | 7.48 |
Endometrial cancer | hsa05213 | 6.81 |
Influenza A | hsa05164 | 5.21 |
PI3K-Akt signaling pathway | hsa04151 | 4.21 |
Hepatitis B | hsa05161 | 5.52 |
Vascular smooth muscle contraction | hsa04270 | 5.74 |
Renal cell carcinoma | hsa05211 | 6.6 |
Gap junction | hsa04540 | 6.24 |
VEGF signaling pathway | hsa04370 | 6.77 |
Proteoglycans in cancer | hsa05205 | 5.02 |
Estrogen signaling pathway | hsa04915 | 6.11 |
MicroRNAs in cancer | hsa05206 | 5.38 |
Toll-like receptor signaling pathway | hsa04620 | 6.0 |
Pathways in cancer | hsa05200 | 3.98 |
GnRH signaling pathway | hsa04912 | 6.18 |
B cell receptor signaling pathway | hsa04662 | 6.52 |
Ras signaling pathway | hsa04014 | 4.9 |
Melanogenesis | hsa04916 | 5.97 |
Glioma | hsa05214 | 6.66 |
Acute myeloid leukemia | hsa05221 | 6.74 |
MAPK signaling pathway | hsa04010 | 4.63 |
Thyroid hormone signaling pathway | hsa04919 | 5.82 |
Long-term depression | hsa04730 | 6.74 |
Regulation of actin cytoskeleton | hsa04810 | 4.9 |
T cell receptor signaling pathway | hsa04660 | 6.01 |
Non-small cell lung cancer | hsa05223 | 6.88 |
Rap1 signaling pathway | hsa04015 | 4.97 |
Fc epsilon RI signaling pathway | hsa04664 | 6.6 |
Prolactin signaling pathway | hsa04917 | 6.6 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Signal transduction by L1 | R-HSA-445144 | 8.59 |
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | R-HSA-2404192 | 4.85 |
Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
NCAM signaling for neurite out-growth | R-HSA-375165 | 4.9 |
Signaling by Interleukins | R-HSA-449147 | 4.71 |
Signaling by Leptin | R-HSA-2586552 | 5.1 |
Frs2-mediated activation | R-HSA-170968 | 5.12 |
MAP2K and MAPK activation | R-HSA-5674135 | 7.66 |
Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
IGF1R signaling cascade | R-HSA-2428924 | 4.85 |
Signaling by FGFR3 | R-HSA-5654741 | 4.69 |
IRS-related events triggered by IGF1R | R-HSA-2428928 | 4.85 |
Signaling by ERBB4 | R-HSA-1236394 | 4.7 |
Innate Immune System | R-HSA-168249 | 3.17 |
IRS-mediated signalling | R-HSA-112399 | 4.87 |
MAPK1/MAPK3 signaling | R-HSA-5684996 | 5.11 |
Downstream signaling of activated FGFR2 | R-HSA-5654696 | 4.71 |
RAF activation | R-HSA-5673000 | 8.34 |
RAF/MAP kinase cascade | R-HSA-5673001 | 5.15 |
Downstream signaling of activated FGFR1 | R-HSA-5654687 | 4.71 |
MAPK family signaling cascades | R-HSA-5683057 | 4.89 |
Signalling by NGF | R-HSA-166520 | 4.23 |
Signaling by VEGF | R-HSA-194138 | 4.66 |
Signalling to p38 via RIT and RIN | R-HSA-187706 | 5.12 |
Developmental Biology | R-HSA-1266738 | 3.48 |
FCERI mediated MAPK activation | R-HSA-2871796 | 4.32 |
Signaling by EGFR | R-HSA-177929 | 4.59 |
FRS-mediated FGFR2 signaling | R-HSA-5654700 | 5.14 |
SOS-mediated signalling | R-HSA-112412 | 5.15 |
FRS-mediated FGFR3 signaling | R-HSA-5654706 | 5.14 |
Disease | R-HSA-1643685 | 3.33 |
Signaling by Insulin receptor | R-HSA-74752 | 4.73 |
Downstream signaling of activated FGFR3 | R-HSA-5654708 | 4.71 |
Insulin receptor signalling cascade | R-HSA-74751 | 4.85 |
Signaling by FGFR4 | R-HSA-5654743 | 4.69 |
RAF-independent MAPK1/3 activation | R-HSA-112409 | 8.46 |
Infectious disease | R-HSA-5663205 | 4.47 |
VEGFA-VEGFR2 Pathway | R-HSA-4420097 | 4.7 |
GRB2 events in ERBB2 signaling | R-HSA-1963640 | 5.15 |
Interleukin receptor SHC signaling | R-HSA-912526 | 5.09 |
L1CAM interactions | R-HSA-373760 | 6.19 |
Signaling by FGFR | R-HSA-190236 | 4.67 |
Fc epsilon receptor (FCERI) signaling | R-HSA-2454202 | 4.03 |
Immune System | R-HSA-168256 | 2.37 |
Downstream signaling of activated FGFR4 | R-HSA-5654716 | 4.71 |
FRS-mediated FGFR4 signaling | R-HSA-5654712 | 5.14 |
Signaling by SCF-KIT | R-HSA-1433557 | 4.73 |
Interleukin-2 signaling | R-HSA-451927 | 5.05 |
SHC1 events in ERBB2 signaling | R-HSA-1250196 | 5.15 |
Signaling by ERBB2 | R-HSA-1227986 | 4.66 |
Signalling to RAS | R-HSA-167044 | 5.08 |
DAP12 signaling | R-HSA-2424491 | 4.64 |
Interleukin-3, 5 and GM-CSF signaling | R-HSA-512988 | 4.99 |
Negative feedback regulation of MAPK pathway | R-HSA-5674499 | 10.4 |
Uptake and actions of bacterial toxins | R-HSA-5339562 | 8.28 |
Signaling by FGFR1 | R-HSA-5654736 | 4.69 |
SHC1 events in EGFR signaling | R-HSA-180336 | 5.15 |
NGF signalling via TRKA from the plasma membrane | R-HSA-187037 | 4.51 |
FRS-mediated FGFR1 signaling | R-HSA-5654693 | 5.14 |
Prolonged ERK activation events | R-HSA-169893 | 5.11 |
Negative regulation of MAPK pathway | R-HSA-5675221 | 7.66 |
Uptake and function of anthrax toxins | R-HSA-5210891 | 9.66 |
Signaling by GPCR | R-HSA-372790 | 2.68 |
Signaling by FGFR2 | R-HSA-5654738 | 4.68 |
GRB2 events in EGFR signaling | R-HSA-179812 | 5.15 |
Signalling to ERKs | R-HSA-187687 | 5.04 |
ARMS-mediated activation | R-HSA-170984 | 5.12 |
MAPK1 (ERK2) activation | R-HSA-112411 | 9.81 |
DAP12 interactions | R-HSA-2172127 | 4.56 |
SHC1 events in ERBB4 signaling | R-HSA-1250347 | 5.15 |
Signaling by PDGF | R-HSA-186797 | 4.53 |
Axon guidance | R-HSA-422475 | 3.93 |
VEGFR2 mediated cell proliferation | R-HSA-5218921 | 5.07 |
Signal Transduction | R-HSA-162582 | 1.78 |
Downstream signal transduction | R-HSA-186763 | 4.65 |
GO term | GO ID | GO IC |
---|---|---|
binding | GO:0005488 | 0.18 |
kinase regulator activity | GO:0019207 | 4.5 |
purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
kinase activator activity | GO:0019209 | 5.58 |
protein complex scaffold | GO:0032947 | 5.5 |
signal transducer activity | GO:0004871 | 2.28 |
nucleotide binding | GO:0000166 | 1.96 |
heterocyclic compound binding | GO:1901363 | 1.06 |
purine nucleoside binding | GO:0001883 | 2.22 |
nucleoside binding | GO:0001882 | 2.21 |
cation binding | GO:0043169 | 1.4 |
molecular function regulator | GO:0098772 | 2.51 |
receptor signaling protein activity | GO:0005057 | 4.76 |
ion binding | GO:0043167 | 1.36 |
protein serine/threonine kinase activity | GO:0004674 | 3.64 |
transferase activity | GO:0016740 | 1.95 |
protein serine/threonine/tyrosine kinase activity | GO:0004712 | 6.07 |
protein tyrosine kinase activity | GO:0004713 | 4.54 |
ribonucleoside binding | GO:0032549 | 2.22 |
purine nucleotide binding | GO:0017076 | 2.19 |
protein kinase activity | GO:0004672 | 3.27 |
metal ion binding | GO:0046872 | 1.41 |
ATP binding | GO:0005524 | 2.43 |
structural molecule activity | GO:0005198 | 3.1 |
protein kinase regulator activity | GO:0019887 | 4.6 |
enzyme regulator activity | GO:0030234 | 2.85 |
kinase activity | GO:0016301 | 2.93 |
nucleoside phosphate binding | GO:1901265 | 1.96 |
small molecule binding | GO:0036094 | 1.89 |
catalytic activity | GO:0003824 | 1.05 |
PDZ domain binding | GO:0030165 | 5.22 |
protein domain specific binding | GO:0019904 | 3.32 |
protein kinase activator activity | GO:0030295 | 5.68 |
protein serine/threonine kinase activator activity | GO:0043539 | 6.91 |
adenyl ribonucleotide binding | GO:0032559 | 2.41 |
adenyl nucleotide binding | GO:0030554 | 2.4 |
carbohydrate derivative binding | GO:0097367 | 2.03 |
organic cyclic compound binding | GO:0097159 | 1.05 |
receptor signaling protein serine/threonine kinase activity | GO:0004702 | 5.23 |
purine ribonucleoside binding | GO:0032550 | 2.22 |
phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
scaffold protein binding | GO:0097110 | 5.93 |
protein binding | GO:0005515 | 0.46 |
transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
purine ribonucleotide binding | GO:0032555 | 2.2 |
MAP kinase kinase activity | GO:0004708 | 7.25 |
ribonucleotide binding | GO:0032553 | 2.19 |
enzyme activator activity | GO:0008047 | 3.56 |