Disease table of CARDIOFACIOCUTANEOUS SYNDROME OMIM ID: PS115150

Gene-disease associations table

GeneAssociated with CARDIOFACIOCUTANEOUS SYNDROME inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MAP2K2ClinVar, OMIM, HUMSAVARHGNC link19p13.31PS115150
MAP2K1ClinVar, OMIM, HUMSAVARHGNC link15q22.311PS115150
BRAFClinVar, OMIM, HUMSAVARHGNC link7q348605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500
KRASClinVar, OMIM, HUMSAVARHGNC link12p12.114601626, 600268, 137215, 109800, PS163950, 211980, 114480, PS115150, 613659, 163200, 607785, 614470, 162900, 260350

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
KRASYES1MYC0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MAP2K2MAP2K1Yes16MAP2K2, WDR83, FLNA, ARAF, MAPK1, MAP2K1, IQGAP1, MAPK3, MAPK8, KSR1, NFE2L2, PDLIM5, RAF1, RPE, BRAF, YWHAB
MAP2K2BRAFYes9MAP2K2, ARAF, MAPK3, MAP2K1, MAPK1, IQGAP1, RAF1, BRAF, YWHAB
MAP2K2KRASNo3MAPK1, ARAF, RAF1
MAP2K1BRAFYes17HSPA1A, HSPA8, NEDD4, ARAF, MAPK1, HRAS, IQGAP1, MAPK3, MAP2K2, KSR1, BRAF, YWHAE, YWHAZ, RAF1, YWHAB, MAP2K1, BRAP
MAP2K1KRASNo5BTRC, ELAVL1, MAPK1, ARAF, RAF1
BRAFKRASNo3MAPK1, ARAF, RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MAP2K1KRASYes1KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MAP2K2MAP2K1Yesbinding65RAC1, CCL11, ARAF, RRAS2, KSR2, YWHAE, MAPK1, PPP2CA, BRAF, DNM1, MAP3K2, CXCL12, AGT, JAK1, PRKACA, YWHAB, GRB2, YWHAH, MAPK11, RRAS, PRKCD, MAP3K1, PIK3R1, KSR1, PLA2G4A, GOLGA1, ARRB1, MOS, RAF1, SOS1, DCC, MAPK14, LAMTOR3, F2, YWHAZ, PPP2CB, LCK, HRAS, IL2, GAB2, PPP2R2B, SHC1, PRKACG, MAPK13, PPP2R1A, PAK1, MAPK12, EDN1, STAT3, KRAS, PRKX, NTN1, MAPK3, PPP2R1B, IL2RB, MAP3K4, YWHAG, PRKACB, SFN, PIK3CA, UBC, MAP3K3, YWHAQ, MAP3K8, PTPN11
MAP2K2BRAFYesactivation, binding24ARAF, MAPK3, KSR2, YWHAE, PPP2CA, RRAS, PRKACA, YWHAB, PRKCD, YWHAH, KSR1, RAF1, YWHAZ, HRAS, PPP2R2B, PPP2R1A, MAP2K1, KRAS, MAPK1, YWHAG, SFN, UBC, YWHAQ, MAP3K1
MAP2K2KRASYesbinding23PTPN11, MAP3K3, ARAF, MAPK3, KSR2, PPP2CA, MAP3K2, MAPK14, KSR1, YWHAB, MAPK11, BRAF, SOS1, RAF1, SHC1, HRAS, MAPK13, MAPK12, MAPK1, PIK3CA, UBC, GRB2, MAP2K1
MAP2K1BRAFYesactivation, binding28MAP2K2, ARAF, MAPK3, KSR2, YWHAE, PPP2CA, PAK2, KRAS, PRKACA, YWHAB, IQGAP1, PRKCD, YWHAH, RRAS, RAF1, YWHAZ, KSR1, HRAS, PPP2R2B, PAK4, PPP2R1A, RPS6KA2, MAPK1, YWHAG, SFN, UBC, YWHAQ, MAP3K1
MAP2K1KRASYesbinding27MAP2K2, ARAF, MAPK3, KSR2, PTPN11, PPP2CA, MAP3K2, MAPK12, KSR1, YWHAB, MAPK11, CCND1, SOS1, ERBB2, ERBB3, RAF1, SHC1, HRAS, MAPK13, GRB2, SRC, MAPK14, MAPK1, PIK3CA, UBC, MAP3K3, BRAF
BRAFKRASYesactivation, binding16MAP2K2, RAF1, ARAF, MAPK1, HRAS, MAPK3, PPP2CA, SPRY2, CNKSR3, KSR2, HSP90AA1, AKT1, UBC, MAP2K1, YWHAB, KSR1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Gene1Gene2Direct InteractionComplexesNumber of shared interactorsShared genes in interaction
MAP2K2MAP2K1YesBRAF-MAP2K1-MAP2K2-YWHAE complex4BRAF, YWHAE, RAF1, KSR1
MAP2K2BRAFYesKSR1-BRAF-MEK complex4MAP2K1, YWHAE, RAF1, KSR1
MAP2K2KRASNo-1RAF1
MAP2K1BRAFYesKSR1-BRAF-MEK complex4MAP2K2, YWHAE, KSR1, RAF1
MAP2K1KRASNo-1RAF1
BRAFKRASNo-1RAF1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
MAP2K1BRAFYes2MAP2K1, BRAF

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Melanomahsa052186.564MAP2K2, MAP2K1, KRAS, BRAF
Bladder cancerhsa052197.384MAP2K2, MAP2K1, KRAS, BRAF
Natural killer cell mediated cytotoxicityhsa046505.534MAP2K2, MAP2K1, KRAS, BRAF
MAPK signaling pathwayhsa040104.634MAP2K2, MAP2K1, KRAS, BRAF
Thyroid cancerhsa052167.484MAP2K2, MAP2K1, KRAS, BRAF
Gliomahsa052146.664MAP2K2, MAP2K1, KRAS, BRAF
Prostate cancerhsa052156.114MAP2K2, MAP2K1, KRAS, BRAF
Long-term potentiationhsa047206.644MAP2K2, MAP2K1, KRAS, BRAF
Neurotrophin signaling pathwayhsa047225.784MAP2K2, MAP2K1, KRAS, BRAF
FoxO signaling pathwayhsa040685.634MAP2K2, MAP2K1, KRAS, BRAF
Endometrial cancerhsa052136.814MAP2K2, MAP2K1, KRAS, BRAF
Renal cell carcinomahsa052116.64MAP2K2, MAP2K1, KRAS, BRAF
Proteoglycans in cancerhsa052055.024MAP2K2, MAP2K1, KRAS, BRAF
Pathways in cancerhsa052003.984MAP2K2, MAP2K1, KRAS, BRAF
Insulin signaling pathwayhsa049105.554MAP2K2, MAP2K1, KRAS, BRAF
Non-small cell lung cancerhsa052236.884MAP2K2, MAP2K1, KRAS, BRAF
ErbB signaling pathwayhsa040126.154MAP2K2, MAP2K1, KRAS, BRAF
Acute myeloid leukemiahsa052216.744MAP2K2, MAP2K1, KRAS, BRAF
Chronic myeloid leukemiahsa052206.484MAP2K2, MAP2K1, KRAS, BRAF
Long-term depressionhsa047306.744MAP2K2, MAP2K1, KRAS, BRAF
Regulation of actin cytoskeletonhsa048104.94MAP2K2, MAP2K1, KRAS, BRAF
Rap1 signaling pathwayhsa040154.974MAP2K2, MAP2K1, KRAS, BRAF
Signaling pathways regulating pluripotency of stem cellshsa045505.63MAP2K2, MAP2K1, KRAS
Pancreatic cancerhsa052126.563MAP2K1, BRAF, KRAS
Colorectal cancerhsa052106.523MAP2K1, BRAF, KRAS
cAMP signaling pathwayhsa040245.053MAP2K2, MAP2K1, BRAF
Central carbon metabolism in cancerhsa052306.73MAP2K2, MAP2K1, KRAS
Choline metabolism in cancerhsa052316.093MAP2K2, MAP2K1, KRAS
Serotonergic synapsehsa047265.843MAP2K1, BRAF, KRAS
Chemokine signaling pathwayhsa040625.193MAP2K1, BRAF, KRAS
Oxytocin signaling pathwayhsa049215.43MAP2K2, MAP2K1, KRAS
Hepatitis Bhsa051615.523MAP2K2, MAP2K1, KRAS
Vascular smooth muscle contractionhsa042705.743MAP2K2, MAP2K1, BRAF
Gap junctionhsa045406.243MAP2K2, MAP2K1, KRAS
VEGF signaling pathwayhsa043706.773MAP2K2, MAP2K1, KRAS
MicroRNAs in cancerhsa052065.383MAP2K2, MAP2K1, KRAS
T cell receptor signaling pathwayhsa046606.013MAP2K2, MAP2K1, KRAS
B cell receptor signaling pathwayhsa046626.523MAP2K2, MAP2K1, KRAS
Ras signaling pathwayhsa040144.93MAP2K2, MAP2K1, KRAS
Melanogenesishsa049165.973MAP2K2, MAP2K1, KRAS
Prolactin signaling pathwayhsa049176.63MAP2K2, MAP2K1, KRAS
Progesterone-mediated oocyte maturationhsa049146.183MAP2K1, BRAF, KRAS
Estrogen signaling pathwayhsa049156.113MAP2K2, MAP2K1, KRAS
Thyroid hormone signaling pathwayhsa049195.823MAP2K2, MAP2K1, KRAS
PI3K-Akt signaling pathwayhsa041514.213MAP2K2, MAP2K1, KRAS
GnRH signaling pathwayhsa049126.183MAP2K2, MAP2K1, KRAS
Alcoholismhsa050345.593MAP2K1, BRAF, KRAS
Fc epsilon RI signaling pathwayhsa046646.63MAP2K2, MAP2K1, KRAS
cGMP-PKG signaling pathwayhsa040225.322MAP2K2, MAP2K1
Toll-like receptor signaling pathwayhsa046206.02MAP2K2, MAP2K1
Influenza Ahsa051645.212MAP2K2, MAP2K1
Cholinergic synapsehsa047255.882MAP2K1, KRAS
Prion diseaseshsa050207.482MAP2K2, MAP2K1
Focal adhesionhsa045104.922MAP2K1, BRAF
HIF-1 signaling pathwayhsa040665.92MAP2K2, MAP2K1
Hepatitis Chsa051605.682BRAF, KRAS
Dorso-ventral axis formationhsa043208.012MAP2K1, KRAS

NET-GE enrichment

Term New enriched termICP valueGenes
Melanoma (hsa05218) -6.560.0MAP2K2, MAP2K1, KRAS, BRAF
Bladder cancer (hsa05219) -7.380.0MAP2K2, MAP2K1, KRAS, BRAF
FoxO signaling pathway (hsa04068) -5.630.0MAP2K2, MAP2K1, KRAS, BRAF
Pancreatic cancer (hsa05212) -6.560.001MAP2K1, BRAF, KRAS
Natural killer cell mediated cytotoxicity (hsa04650) -5.530.0MAP2K2, MAP2K1, KRAS, BRAF
Colorectal cancer (hsa05210) -6.520.001MAP2K1, BRAF, KRAS
Renal cell carcinoma (hsa05211) -6.60.0MAP2K2, MAP2K1, KRAS, BRAF
Thyroid cancer (hsa05216) -7.480.0MAP2K2, MAP2K1, KRAS, BRAF
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.019MAP2K2, MAP2K1, KRAS
Glioma (hsa05214) -6.660.0MAP2K2, MAP2K1, KRAS, BRAF
Prostate cancer (hsa05215) -6.110.0MAP2K2, MAP2K1, KRAS, BRAF
Long-term potentiation (hsa04720) -6.640.0MAP2K2, MAP2K1, KRAS, BRAF
Neurotrophin signaling pathway (hsa04722) -5.780.0MAP2K2, MAP2K1, KRAS, BRAF
Central carbon metabolism in cancer (hsa05230) -6.70.0MAP2K2, MAP2K1, KRAS
Endocrine systemNEW3.260.01MAP2K2, MAP2K1, KRAS, BRAF
Immune systemNEW2.920.026MAP2K2, MAP2K1, KRAS, BRAF
Serotonergic synapse (hsa04726) -5.840.002MAP2K1, BRAF, KRAS
Chemokine signaling pathway (hsa04062) -5.190.007MAP2K1, BRAF, KRAS
Estrogen signaling pathway (hsa04915) -6.110.001MAP2K2, MAP2K1, KRAS
Cellular communityNEW3.570.004MAP2K2, MAP2K1, KRAS, BRAF
Acute myeloid leukemia (hsa05221) -6.740.0MAP2K2, MAP2K1, KRAS, BRAF
Substance dependenceNEW4.770.016MAP2K1, BRAF, KRAS
ErbB signaling pathway (hsa04012) -6.150.0MAP2K2, MAP2K1, KRAS, BRAF
Oxytocin signaling pathway (hsa04921) -5.40.004MAP2K2, MAP2K1, KRAS
Prion diseases (hsa05020) -7.480.044MAP2K2, MAP2K1
Endometrial cancer (hsa05213) -6.810.0MAP2K2, MAP2K1, KRAS, BRAF
Circulatory systemNEW4.630.022MAP2K2, MAP2K1, KRAS, BRAF
Hepatitis B (hsa05161) -5.520.003MAP2K2, MAP2K1, KRAS
Vascular smooth muscle contraction (hsa04270) -5.740.002MAP2K2, MAP2K1, BRAF
Cancers: OverviewNEW2.720.046MAP2K2, MAP2K1, KRAS, BRAF
Cancers: Specific typesNEW4.10.001MAP2K2, MAP2K1, KRAS, BRAF
Gap junction (hsa04540) -6.240.004MAP2K2, MAP2K1, KRAS
VEGF signaling pathway (hsa04370) -6.770.0MAP2K2, MAP2K1, KRAS
Proteoglycans in cancer (hsa05205) -5.020.001MAP2K2, MAP2K1, KRAS, BRAF
Infectious diseases: ViralNEW3.290.009MAP2K2, MAP2K1, KRAS, BRAF
MicroRNAs in cancer (hsa05206) -5.380.02MAP2K2, MAP2K1, KRAS
Pathways in cancer (hsa05200) -3.980.001MAP2K2, MAP2K1, KRAS, BRAF
Rap1 signaling pathway (hsa04015) -4.970.0MAP2K2, MAP2K1, KRAS, BRAF
T cell receptor signaling pathway (hsa04660) -6.010.005MAP2K2, MAP2K1, KRAS
Insulin signaling pathway (hsa04910) -5.550.0MAP2K2, MAP2K1, KRAS, BRAF
Ras signaling pathway (hsa04014) -4.90.001MAP2K2, MAP2K1, KRAS, BRAF
Fc epsilon RI signaling pathway (hsa04664) -6.60.001MAP2K2, MAP2K1, KRAS
cAMP signaling pathway (hsa04024) -5.050.009MAP2K2, MAP2K1, BRAF
Progesterone-mediated oocyte maturation (hsa04914) -6.180.001MAP2K1, BRAF, KRAS
MAPK signaling pathway (hsa04010) -4.630.0MAP2K2, MAP2K1, KRAS, BRAF
Thyroid hormone signaling pathway (hsa04919) -5.820.002MAP2K2, MAP2K1, KRAS
Cell motilityNEW4.90.0MAP2K2, MAP2K1, KRAS, BRAF
Long-term depression (hsa04730) -6.740.0MAP2K2, MAP2K1, KRAS, BRAF
Regulation of actin cytoskeleton (hsa04810) -4.90.0MAP2K2, MAP2K1, KRAS, BRAF
GnRH signaling pathway (hsa04912) -6.180.004MAP2K2, MAP2K1, KRAS
Chronic myeloid leukemia (hsa05220) -6.480.0MAP2K2, MAP2K1, KRAS, BRAF
Nervous systemNEW3.770.031MAP2K2, MAP2K1, KRAS, BRAF
B cell receptor signaling pathway (hsa04662) -6.520.001MAP2K2, MAP2K1, KRAS
Melanogenesis (hsa04916) -5.970.001MAP2K2, MAP2K1, KRAS
Choline metabolism in cancer (hsa05231) -6.090.006MAP2K2, MAP2K1, KRAS
Dorso-ventral axis formation (hsa04320) -8.010.017MAP2K1, KRAS
Alcoholism (hsa05034) -5.590.016MAP2K1, BRAF, KRAS
Non-small cell lung cancer (hsa05223) -6.880.0MAP2K2, MAP2K1, KRAS, BRAF
Prolactin signaling pathway (hsa04917) -6.60.002MAP2K2, MAP2K1, KRAS
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.854MAP2K2, MAP2K1, KRAS, BRAF
Immune SystemR-HSA-1682562.374MAP2K2, MAP2K1, KRAS, BRAF
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.264MAP2K2, MAP2K1, KRAS, BRAF
NCAM signaling for neurite out-growthR-HSA-3751654.94MAP2K2, MAP2K1, KRAS, BRAF
Signaling by InterleukinsR-HSA-4491474.714MAP2K2, MAP2K1, KRAS, BRAF
GRB2 events in ERBB2 signalingR-HSA-19636405.154MAP2K2, MAP2K1, KRAS, BRAF
Frs2-mediated activationR-HSA-1709685.124MAP2K2, MAP2K1, KRAS, BRAF
MAP2K and MAPK activationR-HSA-56741357.664MAP2K2, MAP2K1, KRAS, BRAF
Cytokine Signaling in Immune systemR-HSA-12802153.744MAP2K2, MAP2K1, KRAS, BRAF
IGF1R signaling cascadeR-HSA-24289244.854MAP2K2, MAP2K1, KRAS, BRAF
Downstream signal transductionR-HSA-1867634.654MAP2K2, MAP2K1, KRAS, BRAF
IRS-related events triggered by IGF1RR-HSA-24289284.854MAP2K2, MAP2K1, KRAS, BRAF
Signaling by ERBB4R-HSA-12363944.74MAP2K2, MAP2K1, KRAS, BRAF
Signaling by Insulin receptorR-HSA-747524.734MAP2K2, MAP2K1, KRAS, BRAF
RAF activationR-HSA-56730008.344MAP2K2, MAP2K1, KRAS, BRAF
RAF/MAP kinase cascadeR-HSA-56730015.154MAP2K2, MAP2K1, KRAS, BRAF
Downstream signaling of activated FGFR1R-HSA-56546874.714MAP2K2, MAP2K1, KRAS, BRAF
MAPK family signaling cascadesR-HSA-56830574.894MAP2K2, MAP2K1, KRAS, BRAF
Signaling by LeptinR-HSA-25865525.14MAP2K2, MAP2K1, KRAS, BRAF
Signaling by VEGFR-HSA-1941384.664MAP2K2, MAP2K1, KRAS, BRAF
Signalling to p38 via RIT and RINR-HSA-1877065.124MAP2K2, MAP2K1, KRAS, BRAF
FCERI mediated MAPK activationR-HSA-28717964.324MAP2K2, MAP2K1, KRAS, BRAF
IRS-mediated signallingR-HSA-1123994.874MAP2K2, MAP2K1, KRAS, BRAF
FRS-mediated FGFR2 signalingR-HSA-56547005.144MAP2K2, MAP2K1, KRAS, BRAF
SOS-mediated signallingR-HSA-1124125.154MAP2K2, MAP2K1, KRAS, BRAF
FRS-mediated FGFR3 signalingR-HSA-56547065.144MAP2K2, MAP2K1, KRAS, BRAF
Developmental BiologyR-HSA-12667383.484MAP2K2, MAP2K1, KRAS, BRAF
Downstream signaling of activated FGFR3R-HSA-56547084.714MAP2K2, MAP2K1, KRAS, BRAF
Insulin receptor signalling cascadeR-HSA-747514.854MAP2K2, MAP2K1, KRAS, BRAF
Signaling by FGFR4R-HSA-56547434.694MAP2K2, MAP2K1, KRAS, BRAF
Signaling by FGFR3R-HSA-56547414.694MAP2K2, MAP2K1, KRAS, BRAF
VEGFA-VEGFR2 PathwayR-HSA-44200974.74MAP2K2, MAP2K1, KRAS, BRAF
Signaling by FGFRR-HSA-1902364.674MAP2K2, MAP2K1, KRAS, BRAF
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.034MAP2K2, MAP2K1, KRAS, BRAF
Interleukin-2 signalingR-HSA-4519275.054MAP2K2, MAP2K1, KRAS, BRAF
MAPK1/MAPK3 signalingR-HSA-56849965.114MAP2K2, MAP2K1, KRAS, BRAF
Interleukin receptor SHC signalingR-HSA-9125265.094MAP2K2, MAP2K1, KRAS, BRAF
Innate Immune SystemR-HSA-1682493.174MAP2K2, MAP2K1, KRAS, BRAF
Signaling by SCF-KITR-HSA-14335574.734MAP2K2, MAP2K1, KRAS, BRAF
SHC1 events in ERBB2 signalingR-HSA-12501965.154MAP2K2, MAP2K1, KRAS, BRAF
Signalling to ERKsR-HSA-1876875.044MAP2K2, MAP2K1, KRAS, BRAF
Signaling by PDGFR-HSA-1867974.534MAP2K2, MAP2K1, KRAS, BRAF
Signalling to RASR-HSA-1670445.084MAP2K2, MAP2K1, KRAS, BRAF
DAP12 signalingR-HSA-24244914.644MAP2K2, MAP2K1, KRAS, BRAF
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.994MAP2K2, MAP2K1, KRAS, BRAF
Downstream signaling of activated FGFR2R-HSA-56546964.714MAP2K2, MAP2K1, KRAS, BRAF
SHC1 events in ERBB4 signalingR-HSA-12503475.154MAP2K2, MAP2K1, KRAS, BRAF
SHC1 events in EGFR signalingR-HSA-1803365.154MAP2K2, MAP2K1, KRAS, BRAF
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.514MAP2K2, MAP2K1, KRAS, BRAF
FRS-mediated FGFR1 signalingR-HSA-56546935.144MAP2K2, MAP2K1, KRAS, BRAF
Prolonged ERK activation eventsR-HSA-1698935.114MAP2K2, MAP2K1, KRAS, BRAF
Negative regulation of MAPK pathwayR-HSA-56752217.664MAP2K2, MAP2K1, KRAS, BRAF
FRS-mediated FGFR4 signalingR-HSA-56547125.144MAP2K2, MAP2K1, KRAS, BRAF
Signalling by NGFR-HSA-1665204.234MAP2K2, MAP2K1, KRAS, BRAF
Signaling by GPCRR-HSA-3727902.684MAP2K2, MAP2K1, KRAS, BRAF
Signaling by FGFR2R-HSA-56547384.684MAP2K2, MAP2K1, KRAS, BRAF
GRB2 events in EGFR signalingR-HSA-1798125.154MAP2K2, MAP2K1, KRAS, BRAF
Signaling by FGFR1R-HSA-56547364.694MAP2K2, MAP2K1, KRAS, BRAF
Signaling by EGFRR-HSA-1779294.594MAP2K2, MAP2K1, KRAS, BRAF
ARMS-mediated activationR-HSA-1709845.124MAP2K2, MAP2K1, KRAS, BRAF
DAP12 interactionsR-HSA-21721274.564MAP2K2, MAP2K1, KRAS, BRAF
Downstream signaling of activated FGFR4R-HSA-56547164.714MAP2K2, MAP2K1, KRAS, BRAF
Signaling by ERBB2R-HSA-12279864.664MAP2K2, MAP2K1, KRAS, BRAF
Axon guidanceR-HSA-4224753.934MAP2K2, MAP2K1, KRAS, BRAF
VEGFR2 mediated cell proliferationR-HSA-52189215.074MAP2K2, MAP2K1, KRAS, BRAF
Signal TransductionR-HSA-1625821.784MAP2K2, MAP2K1, KRAS, BRAF
Negative feedback regulation of MAPK pathwayR-HSA-567449910.43MAP2K2, MAP2K1, BRAF
DiseaseR-HSA-16436853.333MAP2K2, MAP2K1, KRAS
Infectious diseaseR-HSA-56632054.472MAP2K2, MAP2K1
Signal transduction by L1R-HSA-4451448.592MAP2K2, MAP2K1
L1CAM interactionsR-HSA-3737606.192MAP2K2, MAP2K1
Uptake and actions of bacterial toxinsR-HSA-53395628.282MAP2K2, MAP2K1
Uptake and function of anthrax toxinsR-HSA-52108919.662MAP2K2, MAP2K1
RAF-independent MAPK1/3 activationR-HSA-1124098.462MAP2K2, MAP2K1

NET-GE enrichment

Term New enriched termICP valueGenes
Signal transduction by L1 (R-HSA-445144) -8.590.007MAP2K2, MAP2K1
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192) -4.850.0MAP2K2, MAP2K1, KRAS, BRAF
FCERI mediated MAPK activation (R-HSA-2871796) -4.320.004MAP2K2, MAP2K1, KRAS, BRAF
Downstream signaling of activated FGFR4 (R-HSA-5654716) -4.710.0MAP2K2, MAP2K1, KRAS, BRAF
Signaling by Interleukins (R-HSA-449147) -4.710.0MAP2K2, MAP2K1, KRAS, BRAF
Interleukin-2 signaling (R-HSA-451927) -5.050.0MAP2K2, MAP2K1, KRAS, BRAF
Frs2-mediated activation (R-HSA-170968) -5.120.0MAP2K2, MAP2K1, KRAS, BRAF
MAP2K and MAPK activation (R-HSA-5674135) -7.660.0MAP2K2, MAP2K1, KRAS, BRAF
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.004MAP2K2, MAP2K1, KRAS, BRAF
IGF1R signaling cascade (R-HSA-2428924) -4.850.0MAP2K2, MAP2K1, KRAS, BRAF
Downstream signal transduction (R-HSA-186763) -4.650.0MAP2K2, MAP2K1, KRAS, BRAF
IRS-related events triggered by IGF1R (R-HSA-2428928) -4.850.0MAP2K2, MAP2K1, KRAS, BRAF
Signaling by ERBB4 (R-HSA-1236394) -4.70.004MAP2K2, MAP2K1, KRAS, BRAF
IRS-mediated signalling (R-HSA-112399) -4.870.0MAP2K2, MAP2K1, KRAS, BRAF
MAPK1/MAPK3 signaling (R-HSA-5684996) -5.110.0MAP2K2, MAP2K1, KRAS, BRAF
Downstream signaling of activated FGFR2 (R-HSA-5654696) -4.710.0MAP2K2, MAP2K1, KRAS, BRAF
RAF activation (R-HSA-5673000) -8.340.0MAP2K2, MAP2K1, KRAS, BRAF
Insulin receptor signalling cascade (R-HSA-74751) -4.850.0MAP2K2, MAP2K1, KRAS, BRAF
Downstream signaling of activated FGFR1 (R-HSA-5654687) -4.710.0MAP2K2, MAP2K1, KRAS, BRAF
MAPK family signaling cascades (R-HSA-5683057) -4.890.0MAP2K2, MAP2K1, KRAS, BRAF
Signalling by NGF (R-HSA-166520) -4.230.001MAP2K2, MAP2K1, KRAS, BRAF
Signaling by VEGF (R-HSA-194138) -4.660.0MAP2K2, MAP2K1, KRAS, BRAF
Signalling to p38 via RIT and RIN (R-HSA-187706) -5.120.001MAP2K2, MAP2K1, KRAS, BRAF
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907) -4.260.013MAP2K2, MAP2K1, KRAS, BRAF
Signaling by EGFR (R-HSA-177929) -4.590.005MAP2K2, MAP2K1, KRAS, BRAF
FRS-mediated FGFR2 signaling (R-HSA-5654700) -5.140.0MAP2K2, MAP2K1, KRAS, BRAF
DAP12 interactions (R-HSA-2172127) -4.560.006MAP2K2, MAP2K1, KRAS, BRAF
FRS-mediated FGFR3 signaling (R-HSA-5654706) -5.140.0MAP2K2, MAP2K1, KRAS, BRAF
Developmental Biology (R-HSA-1266738) -3.480.009MAP2K2, MAP2K1, KRAS, BRAF
Signaling by Insulin receptor (R-HSA-74752) -4.730.004MAP2K2, MAP2K1, KRAS, BRAF
Downstream signaling of activated FGFR3 (R-HSA-5654708) -4.710.0MAP2K2, MAP2K1, KRAS, BRAF
RAF/MAP kinase cascade (R-HSA-5673001) -5.150.0MAP2K2, MAP2K1, KRAS, BRAF
Signaling by FGFR4 (R-HSA-5654743) -4.690.0MAP2K2, MAP2K1, KRAS, BRAF
RAF-independent MAPK1/3 activation (R-HSA-112409) -8.460.006MAP2K2, MAP2K1
Signaling by FGFR3 (R-HSA-5654741) -4.690.0MAP2K2, MAP2K1, KRAS, BRAF
VEGFA-VEGFR2 Pathway (R-HSA-4420097) -4.70.0MAP2K2, MAP2K1, KRAS, BRAF
GRB2 events in ERBB2 signaling (R-HSA-1963640) -5.150.001MAP2K2, MAP2K1, KRAS, BRAF
Signaling by FGFR (R-HSA-190236) -4.670.0MAP2K2, MAP2K1, KRAS, BRAF
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202) -4.030.012MAP2K2, MAP2K1, KRAS, BRAF
Signaling by Leptin (R-HSA-2586552) -5.10.001MAP2K2, MAP2K1, KRAS, BRAF
Signaling by ERBB2 (R-HSA-1227986) -4.660.0MAP2K2, MAP2K1, KRAS, BRAF
Interleukin receptor SHC signaling (R-HSA-912526) -5.090.0MAP2K2, MAP2K1, KRAS, BRAF
Innate Immune System (R-HSA-168249) -3.170.02MAP2K2, MAP2K1, KRAS, BRAF
Signaling by SCF-KIT (R-HSA-1433557) -4.730.003MAP2K2, MAP2K1, KRAS, BRAF
Negative feedback regulation of MAPK pathway (R-HSA-5674499) -10.40.0MAP2K2, MAP2K1, BRAF
Signalling to ERKs (R-HSA-187687) -5.040.0MAP2K2, MAP2K1, KRAS, BRAF
NCAM signaling for neurite out-growth (R-HSA-375165) -4.90.002MAP2K2, MAP2K1, KRAS, BRAF
Signalling to RAS (R-HSA-167044) -5.080.001MAP2K2, MAP2K1, KRAS, BRAF
DAP12 signaling (R-HSA-2424491) -4.640.0MAP2K2, MAP2K1, KRAS, BRAF
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988) -4.990.001MAP2K2, MAP2K1, KRAS, BRAF
Uptake and actions of bacterial toxins (R-HSA-5339562) -8.280.008MAP2K2, MAP2K1
SHC1 events in ERBB4 signaling (R-HSA-1250347) -5.150.0MAP2K2, MAP2K1, KRAS, BRAF
SHC1 events in EGFR signaling (R-HSA-180336) -5.150.0MAP2K2, MAP2K1, KRAS, BRAF
NGF signalling via TRKA from the plasma membrane (R-HSA-187037) -4.510.008MAP2K2, MAP2K1, KRAS, BRAF
FRS-mediated FGFR1 signaling (R-HSA-5654693) -5.140.0MAP2K2, MAP2K1, KRAS, BRAF
Prolonged ERK activation events (R-HSA-169893) -5.110.0MAP2K2, MAP2K1, KRAS, BRAF
Negative regulation of MAPK pathway (R-HSA-5675221) -7.660.0MAP2K2, MAP2K1, KRAS, BRAF
Uptake and function of anthrax toxins (R-HSA-5210891) -9.660.001MAP2K2, MAP2K1
Signaling by FGFR2 (R-HSA-5654738) -4.680.004MAP2K2, MAP2K1, KRAS, BRAF
GRB2 events in EGFR signaling (R-HSA-179812) -5.150.001MAP2K2, MAP2K1, KRAS, BRAF
SHC1 events in ERBB2 signaling (R-HSA-1250196) -5.150.0MAP2K2, MAP2K1, KRAS, BRAF
ARMS-mediated activation (R-HSA-170984) -5.120.001MAP2K2, MAP2K1, KRAS, BRAF
SOS-mediated signalling (R-HSA-112412) -5.150.001MAP2K2, MAP2K1, KRAS, BRAF
Signaling by FGFR1 (R-HSA-5654736) -4.690.004MAP2K2, MAP2K1, KRAS, BRAF
Signaling by PDGF (R-HSA-186797) -4.530.007MAP2K2, MAP2K1, KRAS, BRAF
Axon guidance (R-HSA-422475) -3.930.002MAP2K2, MAP2K1, KRAS, BRAF
VEGFR2 mediated cell proliferation (R-HSA-5218921) -5.070.001MAP2K2, MAP2K1, KRAS, BRAF
FRS-mediated FGFR4 signaling (R-HSA-5654712) -5.140.0MAP2K2, MAP2K1, KRAS, BRAF
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
purine ribonucleoside triphosphate binding (GO:0035639) 2.224MAP2K2, MAP2K1, KRAS, BRAF
carbohydrate derivative binding (GO:0097367) 2.034MAP2K2, MAP2K1, KRAS, BRAF
nucleoside phosphate binding (GO:1901265) 1.964MAP2K2, MAP2K1, KRAS, BRAF
nucleotide binding (GO:0000166) 1.964MAP2K2, MAP2K1, KRAS, BRAF
small molecule binding (GO:0036094) 1.894MAP2K2, MAP2K1, KRAS, BRAF
catalytic activity (GO:0003824) 1.054MAP2K2, MAP2K1, KRAS, BRAF
purine ribonucleoside binding (GO:0032550) 2.224MAP2K2, MAP2K1, KRAS, BRAF
ribonucleotide binding (GO:0032553) 2.194MAP2K2, MAP2K1, KRAS, BRAF
binding (GO:0005488) 0.184MAP2K2, MAP2K1, KRAS, BRAF
protein binding (GO:0005515) 0.464MAP2K2, MAP2K1, KRAS, BRAF
ribonucleoside binding (GO:0032549) 2.224MAP2K2, MAP2K1, KRAS, BRAF
purine ribonucleotide binding (GO:0032555) 2.24MAP2K2, MAP2K1, KRAS, BRAF
purine nucleotide binding (GO:0017076) 2.194MAP2K2, MAP2K1, KRAS, BRAF
organic cyclic compound binding (GO:0097159) 1.054MAP2K2, MAP2K1, KRAS, BRAF
heterocyclic compound binding (GO:1901363) 1.064MAP2K2, MAP2K1, KRAS, BRAF
purine nucleoside binding (GO:0001883) 2.224MAP2K2, MAP2K1, KRAS, BRAF
nucleoside binding (GO:0001882) 2.214MAP2K2, MAP2K1, KRAS, BRAF
cation binding (GO:0043169) 1.43MAP2K2, BRAF, KRAS
adenyl nucleotide binding (GO:0030554) 2.43MAP2K2, MAP2K1, BRAF
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.083MAP2K2, MAP2K1, BRAF
receptor signaling protein activity (GO:0005057) 4.763MAP2K2, MAP2K1, BRAF
kinase activity (GO:0016301) 2.933MAP2K2, MAP2K1, BRAF
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.773MAP2K2, MAP2K1, BRAF
ion binding (GO:0043167) 1.363MAP2K2, BRAF, KRAS
protein serine/threonine kinase activity (GO:0004674) 3.643MAP2K2, MAP2K1, BRAF
transferase activity (GO:0016740) 1.953MAP2K2, MAP2K1, BRAF
receptor signaling protein serine/threonine kinase activity (GO:0004702) 5.233MAP2K2, MAP2K1, BRAF
adenyl ribonucleotide binding (GO:0032559) 2.413MAP2K2, MAP2K1, BRAF
signal transducer activity (GO:0004871) 2.283MAP2K2, MAP2K1, BRAF
protein kinase activity (GO:0004672) 3.273MAP2K2, MAP2K1, BRAF
metal ion binding (GO:0046872) 1.413MAP2K2, BRAF, KRAS
ATP binding (GO:0005524) 2.433MAP2K2, MAP2K1, BRAF
hydrolase activity (GO:0016787) 1.92MAP2K1, KRAS
kinase regulator activity (GO:0019207) 4.52MAP2K2, MAP2K1
protein kinase regulator activity (GO:0019887) 4.62MAP2K2, MAP2K1
enzyme regulator activity (GO:0030234) 2.852MAP2K2, MAP2K1
kinase activator activity (GO:0019209) 5.582MAP2K2, MAP2K1
protein domain specific binding (GO:0019904) 3.322MAP2K2, KRAS
enzyme binding (GO:0019899) 2.272MAP2K1, BRAF
MAP kinase kinase activity (GO:0004708) 7.252MAP2K2, MAP2K1
protein kinase binding (GO:0019901) 3.442MAP2K1, BRAF
kinase binding (GO:0019900) 3.322MAP2K1, BRAF
protein serine/threonine/tyrosine kinase activity (GO:0004712) 6.072MAP2K2, MAP2K1
enzyme activator activity (GO:0008047) 3.562MAP2K2, MAP2K1
molecular function regulator (GO:0098772) 2.512MAP2K2, MAP2K1
protein kinase activator activity (GO:0030295) 5.682MAP2K2, MAP2K1
protein serine/threonine kinase activator activity (GO:0043539) 6.912MAP2K2, MAP2K1
protein tyrosine kinase activity (GO:0004713) 4.542MAP2K2, MAP2K1

NET-GE enrichment

Term New enriched termICP valueGenes
kinase regulator activity (GO:0019207) -4.50.028MAP2K2, MAP2K1
purine ribonucleoside triphosphate binding (GO:0035639) -2.220.014MAP2K2, MAP2K1, KRAS, BRAF
kinase activator activity (GO:0019209) -5.580.004MAP2K2, MAP2K1
enzyme activator activity (GO:0008047) -3.560.005MAP2K2, MAP2K1, KRAS, BRAF
nucleotide binding (GO:0000166) -1.960.037MAP2K2, MAP2K1, KRAS, BRAF
purine nucleoside binding (GO:0001883) -2.220.014MAP2K2, MAP2K1, KRAS, BRAF
nucleoside binding (GO:0001882) -2.210.014MAP2K2, MAP2K1, KRAS, BRAF
anion binding (GO:0043168) NEW4.170.049MAP2K2, MAP2K1, KRAS, BRAF
receptor signaling protein activity (GO:0005057) -4.760.004MAP2K2, MAP2K1, BRAF
structural molecule activity (GO:0005198) NEW3.10.012MAP2K2, MAP2K1, KRAS, BRAF
protein serine/threonine kinase activity (GO:0004674) -3.640.006MAP2K2, MAP2K1, BRAF
protein serine/threonine/tyrosine kinase activity (GO:0004712) -6.070.003MAP2K2, MAP2K1
protein tyrosine kinase activity (GO:0004713) -4.540.032MAP2K2, MAP2K1
ribonucleoside binding (GO:0032549) -2.220.014MAP2K2, MAP2K1, KRAS, BRAF
purine nucleotide binding (GO:0017076) -2.190.015MAP2K2, MAP2K1, KRAS, BRAF
kinase activity (GO:0016301) -2.930.042MAP2K2, MAP2K1, KRAS, BRAF
protein kinase regulator activity (GO:0019887) -4.60.022MAP2K2, MAP2K1
protein kinase activity (GO:0004672) -3.270.017MAP2K2, MAP2K1, KRAS, BRAF
nucleoside phosphate binding (GO:1901265) -1.960.037MAP2K2, MAP2K1, KRAS, BRAF
kinase binding (GO:0019900) -3.320.008MAP2K2, MAP2K1, KRAS, BRAF
protein kinase activator activity (GO:0030295) -5.680.004MAP2K2, MAP2K1
protein serine/threonine kinase activator activity (GO:0043539) -6.910.002MAP2K2, MAP2K1
binding, bridging (GO:0060090) NEW4.570.01MAP2K2, MAP2K1, KRAS
carbohydrate derivative binding (GO:0097367) -2.030.027MAP2K2, MAP2K1, KRAS, BRAF
MAP kinase kinase activity (GO:0004708) -7.250.002MAP2K2, MAP2K1
phosphotransferase activity, alcohol group as acceptor (GO:0016773) -3.080.027MAP2K2, MAP2K1, KRAS, BRAF
purine ribonucleotide binding (GO:0032555) -2.20.015MAP2K2, MAP2K1, KRAS, BRAF
purine ribonucleoside binding (GO:0032550) -2.220.014MAP2K2, MAP2K1, KRAS, BRAF
ribonucleotide binding (GO:0032553) -2.190.015MAP2K2, MAP2K1, KRAS, BRAF
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
positive regulation of protein modification process (GO:0031401) 2.74MAP2K2, MAP2K1, KRAS, BRAF
regulation of phosphate metabolic process (GO:0019220) 2.354MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of metabolic process (GO:0009893) 1.744MAP2K2, MAP2K1, KRAS, BRAF
regulation of metabolic process (GO:0019222) 1.024MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of kinase activity (GO:0033674) 3.544MAP2K2, MAP2K1, KRAS, BRAF
regulation of protein metabolic process (GO:0051246) 1.934MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of cell communication (GO:0010647) 2.414MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of response to stimulus (GO:0048584) 2.184MAP2K2, MAP2K1, KRAS, BRAF
regulation of response to stimulus (GO:0048583) 1.544MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of signaling (GO:0023056) 2.414MAP2K2, MAP2K1, KRAS, BRAF
regulation of MAP kinase activity (GO:0043405) 3.954MAP2K2, MAP2K1, KRAS, BRAF
cellular process (GO:0009987) 0.264MAP2K2, MAP2K1, KRAS, BRAF
regulation of phosphorus metabolic process (GO:0051174) 2.354MAP2K2, MAP2K1, KRAS, BRAF
signal transduction (GO:0007165) 1.284MAP2K2, MAP2K1, KRAS, BRAF
regulation of signaling (GO:0023051) 1.724MAP2K2, MAP2K1, KRAS, BRAF
intracellular signal transduction (GO:0035556) 2.394MAP2K2, MAP2K1, KRAS, BRAF
regulation of protein serine/threonine kinase activity (GO:0071900) 3.584MAP2K2, MAP2K1, KRAS, BRAF
regulation of biological process (GO:0050789) 0.454MAP2K2, MAP2K1, KRAS, BRAF
single-organism process (GO:0044699) 0.484MAP2K2, MAP2K1, KRAS, BRAF
regulation of MAPK cascade (GO:0043408) 3.224MAP2K2, MAP2K1, KRAS, BRAF
cellular protein metabolic process (GO:0044267) 1.634MAP2K2, MAP2K1, KRAS, BRAF
single-organism metabolic process (GO:0044710) 1.634MAP2K2, MAP2K1, KRAS, BRAF
anatomical structure morphogenesis (GO:0009653) 2.534MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of transferase activity (GO:0051347) 3.314MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of macromolecule metabolic process (GO:0010604) 1.814MAP2K2, MAP2K1, KRAS, BRAF
cellular macromolecule metabolic process (GO:0044260) 0.934MAP2K2, MAP2K1, KRAS, BRAF
regulation of cell communication (GO:0010646) 1.734MAP2K2, MAP2K1, KRAS, BRAF
regulation of signal transduction (GO:0009966) 1.844MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of signal transduction (GO:0009967) 2.54MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of phosphorus metabolic process (GO:0010562) 2.784MAP2K2, MAP2K1, KRAS, BRAF
regulation of kinase activity (GO:0043549) 3.074MAP2K2, MAP2K1, KRAS, BRAF
MAPK cascade (GO:0000165) 3.914MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of protein metabolic process (GO:0051247) 2.434MAP2K2, MAP2K1, KRAS, BRAF
organic substance metabolic process (GO:0071704) 0.634MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of cellular protein metabolic process (GO:0032270) 2.494MAP2K2, MAP2K1, KRAS, BRAF
signal transduction by protein phosphorylation (GO:0023014) 3.794MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of molecular function (GO:0044093) 2.234MAP2K2, MAP2K1, KRAS, BRAF
regulation of protein modification process (GO:0031399) 2.324MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of biological process (GO:0048518) 1.24MAP2K2, MAP2K1, KRAS, BRAF
negative regulation of biological process (GO:0048519) 1.334MAP2K2, MAP2K1, KRAS, BRAF
regulation of molecular function (GO:0065009) 1.784MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of cellular metabolic process (GO:0031325) 1.814MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of catalytic activity (GO:0043085) 2.44MAP2K2, MAP2K1, KRAS, BRAF
developmental process (GO:0032502) 1.364MAP2K2, MAP2K1, KRAS, BRAF
protein phosphorylation (GO:0006468) 2.894MAP2K2, MAP2K1, KRAS, BRAF
regulation of catalytic activity (GO:0050790) 1.974MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of phosphate metabolic process (GO:0045937) 2.784MAP2K2, MAP2K1, KRAS, BRAF
primary metabolic process (GO:0044238) 0.694MAP2K2, MAP2K1, KRAS, BRAF
regulation of macromolecule metabolic process (GO:0060255) 1.084MAP2K2, MAP2K1, KRAS, BRAF
regulation of cellular metabolic process (GO:0031323) 1.074MAP2K2, MAP2K1, KRAS, BRAF
regulation of protein kinase activity (GO:0045859) 3.154MAP2K2, MAP2K1, KRAS, BRAF
regulation of primary metabolic process (GO:0080090) 1.084MAP2K2, MAP2K1, KRAS, BRAF
cellular protein modification process (GO:0006464) 1.794MAP2K2, MAP2K1, KRAS, BRAF
regulation of cellular process (GO:0050794) 0.54MAP2K2, MAP2K1, KRAS, BRAF
single-organism developmental process (GO:0044767) 1.494MAP2K2, MAP2K1, KRAS, BRAF
regulation of gene expression (GO:0010468) 1.374MAP2K2, MAP2K1, KRAS, BRAF
macromolecule modification (GO:0043412) 1.734MAP2K2, MAP2K1, KRAS, BRAF
protein modification process (GO:0036211) 1.794MAP2K2, MAP2K1, KRAS, BRAF
single-organism cellular process (GO:0044763) 0.654MAP2K2, MAP2K1, KRAS, BRAF
metabolic process (GO:0008152) 0.584MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of intracellular signal transduction (GO:1902533) 2.954MAP2K2, MAP2K1, KRAS, BRAF
regulation of intracellular signal transduction (GO:1902531) 2.314MAP2K2, MAP2K1, KRAS, BRAF
regulation of phosphorylation (GO:0042325) 2.54MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of MAPK cascade (GO:0043410) 3.574MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of phosphorylation (GO:0042327) 2.94MAP2K2, MAP2K1, KRAS, BRAF
regulation of cellular protein metabolic process (GO:0032268) 1.994MAP2K2, MAP2K1, KRAS, BRAF
protein metabolic process (GO:0019538) 1.454MAP2K2, MAP2K1, KRAS, BRAF
regulation of response to stress (GO:0080134) 2.534MAP2K2, MAP2K1, KRAS, BRAF
anatomical structure development (GO:0048856) 1.584MAP2K2, MAP2K1, KRAS, BRAF
regulation of cell differentiation (GO:0045595) 2.424MAP2K2, MAP2K1, KRAS, BRAF
regulation of transferase activity (GO:0051338) 2.884MAP2K2, MAP2K1, KRAS, BRAF
macromolecule metabolic process (GO:0043170) 0.834MAP2K2, MAP2K1, KRAS, BRAF
biological regulation (GO:0065007) 0.394MAP2K2, MAP2K1, KRAS, BRAF
phosphate-containing compound metabolic process (GO:0006796) 2.164MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of gene expression (GO:0010628) 2.354MAP2K2, MAP2K1, KRAS, BRAF
phosphorus metabolic process (GO:0006793) 2.154MAP2K2, MAP2K1, KRAS, BRAF
regulation of protein phosphorylation (GO:0001932) 2.574MAP2K2, MAP2K1, KRAS, BRAF
cellular metabolic process (GO:0044237) 0.694MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of protein kinase activity (GO:0045860) 3.614MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of protein phosphorylation (GO:0001934) 2.954MAP2K2, MAP2K1, KRAS, BRAF
phosphorylation (GO:0016310) 2.634MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of cellular process (GO:0048522) 1.34MAP2K2, MAP2K1, KRAS, BRAF
regulation of cell morphogenesis (GO:0022604) 3.43MAP2K2, MAP2K1, BRAF
thyroid gland development (GO:0030878) 6.473MAP2K2, MAP2K1, BRAF
regulation of cellular response to stress (GO:0080135) 3.43MAP2K2, MAP2K1, BRAF
regulation of neuron projection development (GO:0010975) 3.693MAP2K2, MAP2K1, BRAF
regulation of cellular localization (GO:0060341) 3.033MAP2K2, MAP2K1, BRAF
regulation of organelle organization (GO:0033043) 2.723MAP2K2, MAP2K1, BRAF
regulation of transport (GO:0051049) 2.243MAP2K2, MAP2K1, BRAF
cell differentiation (GO:0030154) 2.143MAP2K1, BRAF, KRAS
regulation of axon regeneration (GO:0048679) 6.783MAP2K2, MAP2K1, BRAF
activation of protein kinase activity (GO:0032147) 4.083MAP2K2, MAP2K1, BRAF
regulation of cellular component organization (GO:0051128) 2.013MAP2K2, MAP2K1, BRAF
positive regulation of MAP kinase activity (GO:0043406) 4.393MAP2K2, MAP2K1, KRAS
positive regulation of developmental process (GO:0051094) 2.773MAP2K2, MAP2K1, BRAF
face development (GO:0060324) 6.783MAP2K2, MAP2K1, BRAF
regulation of nervous system development (GO:0051960) 3.13MAP2K2, MAP2K1, BRAF
positive regulation of protein serine/threonine kinase activity (GO:0071902) 4.063MAP2K2, MAP2K1, KRAS
regulation of cell projection organization (GO:0031344) 3.383MAP2K2, MAP2K1, BRAF
cellular component organization or biogenesis (GO:0071840) 1.223MAP2K1, BRAF, KRAS
positive regulation of cell projection organization (GO:0031346) 3.993MAP2K2, MAP2K1, BRAF
regulation of neurogenesis (GO:0050767) 3.213MAP2K2, MAP2K1, BRAF
regulation of transcription, DNA-templated (GO:0006355) 1.563MAP2K2, MAP2K1, KRAS
cellular developmental process (GO:0048869) 1.823MAP2K1, BRAF, KRAS
positive regulation of multicellular organismal process (GO:0051240) 2.493MAP2K2, MAP2K1, BRAF
regulation of response to external stimulus (GO:0032101) 3.063MAP2K2, MAP2K1, BRAF
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463MAP2K2, MAP2K1, KRAS
regulation of cell development (GO:0060284) 3.013MAP2K2, MAP2K1, BRAF
positive regulation of neurogenesis (GO:0050769) 3.773MAP2K2, MAP2K1, BRAF
regulation of neuron differentiation (GO:0045664) 3.393MAP2K2, MAP2K1, BRAF
positive regulation of neuron differentiation (GO:0045666) 3.983MAP2K2, MAP2K1, BRAF
regulation of neuron projection regeneration (GO:0070570) 6.683MAP2K2, MAP2K1, BRAF
positive regulation of cell development (GO:0010720) 3.573MAP2K2, MAP2K1, BRAF
regulation of cellular biosynthetic process (GO:0031326) 1.383MAP2K2, MAP2K1, KRAS
hematopoietic or lymphoid organ development (GO:0048534) 4.493MAP2K2, MAP2K1, BRAF
regulation of anatomical structure morphogenesis (GO:0022603) 2.793MAP2K2, MAP2K1, BRAF
regulation of cell proliferation (GO:0042127) 2.413MAP2K1, BRAF, KRAS
organ morphogenesis (GO:0009887) 3.553MAP2K2, MAP2K1, BRAF
thymus development (GO:0048538) 5.883MAP2K2, MAP2K1, BRAF
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433MAP2K2, MAP2K1, KRAS
regulation of biosynthetic process (GO:0009889) 1.373MAP2K2, MAP2K1, KRAS
regulation of nucleic acid-templated transcription (GO:1903506) 1.553MAP2K2, MAP2K1, KRAS
regulation of vesicle-mediated transport (GO:0060627) 3.633MAP2K2, MAP2K1, BRAF
positive regulation of cell differentiation (GO:0045597) 3.013MAP2K2, MAP2K1, BRAF
regulation of nitrogen compound metabolic process (GO:0051171) 1.363MAP2K2, MAP2K1, KRAS
regulation of multicellular organismal process (GO:0051239) 1.873MAP2K2, MAP2K1, BRAF
regulation of RNA biosynthetic process (GO:2001141) 1.553MAP2K2, MAP2K1, KRAS
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.913MAP2K2, MAP2K1, BRAF
regulation of localization (GO:0032879) 1.943MAP2K2, MAP2K1, BRAF
multi-organism process (GO:0051704) 2.653MAP2K2, MAP2K1, KRAS
animal organ development (GO:0048513) 2.533MAP2K2, MAP2K1, BRAF
regulation of axonogenesis (GO:0050770) 4.593MAP2K2, MAP2K1, BRAF
positive regulation of axonogenesis (GO:0050772) 5.493MAP2K2, MAP2K1, BRAF
regulation of response to wounding (GO:1903034) 4.743MAP2K2, MAP2K1, BRAF
response to stimulus (GO:0050896) 1.223MAP2K1, BRAF, KRAS
regulation of RNA metabolic process (GO:0051252) 1.523MAP2K2, MAP2K1, KRAS
regulation of developmental process (GO:0050793) 2.13MAP2K2, MAP2K1, BRAF
positive regulation of nervous system development (GO:0051962) 3.643MAP2K2, MAP2K1, BRAF
cellular component organization (GO:0016043) 1.243MAP2K1, BRAF, KRAS
regulation of macromolecule biosynthetic process (GO:0010556) 1.433MAP2K2, MAP2K1, KRAS
regulation of multicellular organismal development (GO:2000026) 2.313MAP2K2, MAP2K1, BRAF
positive regulation of cell morphogenesis involved in differentiation (GO:0010770) 4.653MAP2K2, MAP2K1, BRAF
gland development (GO:0048732) 4.153MAP2K2, MAP2K1, BRAF
positive regulation of ERK1 and ERK2 cascade (GO:0070374) 4.563MAP2K2, MAP2K1, BRAF
positive regulation of cellular component organization (GO:0051130) 2.683MAP2K2, MAP2K1, BRAF
regulation of ERK1 and ERK2 cascade (GO:0070372) 4.233MAP2K2, MAP2K1, BRAF
negative regulation of cellular process (GO:0048523) 1.413MAP2K1, BRAF, KRAS
positive regulation of neuron projection development (GO:0010976) 4.263MAP2K2, MAP2K1, BRAF
response to abiotic stimulus (GO:0009628) 2.82BRAF, KRAS
regulation of intracellular transport (GO:0032386) 3.582MAP2K2, MAP2K1
learning (GO:0007612) 4.852BRAF, KRAS
behavior (GO:0007610) 3.472BRAF, KRAS
learning or memory (GO:0007611) 4.332BRAF, KRAS
regulation of neuron apoptotic process (GO:0043523) 4.472BRAF, KRAS
negative regulation of neuron apoptotic process (GO:0043524) 4.822BRAF, KRAS
cellular response to stimulus (GO:0051716) 1.972MAP2K1, BRAF
negative regulation of macromolecule metabolic process (GO:0010605) 2.012MAP2K2, MAP2K1
posttranscriptional regulation of gene expression (GO:0010608) 3.642MAP2K2, MAP2K1
peptidyl-tyrosine modification (GO:0018212) 4.472MAP2K2, MAP2K1
peptidyl-amino acid modification (GO:0018193) 2.982MAP2K2, MAP2K1
response to organic substance (GO:0010033) 2.22BRAF, KRAS
negative regulation of cell death (GO:0060548) 2.952BRAF, KRAS
regulation of posttranscriptional gene silencing (GO:0060147) 6.552MAP2K2, MAP2K1
positive regulation of posttranscriptional gene silencing (GO:0060148) 7.162MAP2K2, MAP2K1
system process (GO:0003008) 2.32BRAF, KRAS
regulation of Golgi inheritance (GO:0090170) 8.342MAP2K2, MAP2K1
single-multicellular organism process (GO:0044707) 1.782BRAF, KRAS
cell motility (GO:0048870) 3.022MAP2K1, KRAS
single-organism behavior (GO:0044708) 3.792BRAF, KRAS
immune system process (GO:0002376) 2.292BRAF, KRAS
positive regulation of gene silencing by miRNA (GO:2000637) 7.242MAP2K2, MAP2K1
visual behavior (GO:0007632) 5.822BRAF, KRAS
negative regulation of metabolic process (GO:0009892) 1.932MAP2K2, MAP2K1
positive regulation of biosynthetic process (GO:0009891) 2.292MAP2K2, MAP2K1
regulation of production of miRNAs involved in gene silencing by miRNA (GO:1903798) 7.532MAP2K2, MAP2K1
movement of cell or subcellular component (GO:0006928) 2.612MAP2K1, KRAS
negative regulation of gene expression (GO:0010629) 2.482MAP2K2, MAP2K1
multi-organism metabolic process (GO:0044033) 6.782MAP2K2, MAP2K1
regulation of apoptotic process (GO:0042981) 2.52BRAF, KRAS
positive regulation of production of miRNAs involved in gene silencing by miRNA (GO:1903800) 8.632MAP2K2, MAP2K1
positive regulation of RNA metabolic process (GO:0051254) 2.512MAP2K2, MAP2K1
regulation of biological quality (GO:0065008) 1.682BRAF, KRAS
organ formation (GO:0048645) 6.732MAP2K2, MAP2K1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012MAP2K2, MAP2K1
regulation of early endosome to late endosome transport (GO:2000641) 6.962MAP2K2, MAP2K1
regulation of cytoplasmic transport (GO:1903649) 6.92MAP2K2, MAP2K1
associative learning (GO:0008306) 5.442BRAF, KRAS
regulation of neuron death (GO:1901214) 4.192BRAF, KRAS
negative regulation of neuron death (GO:1901215) 4.572BRAF, KRAS
cognition (GO:0050890) 4.22BRAF, KRAS
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392MAP2K2, MAP2K1
regulation of cell motility (GO:2000145) 3.162MAP2K2, BRAF
regulation of synapse structure or activity (GO:0050803) 4.772BRAF, KRAS
response to radiation (GO:0009314) 3.692BRAF, KRAS
modulation of synaptic transmission (GO:0050804) 4.092BRAF, KRAS
response to light stimulus (GO:0009416) 4.082BRAF, KRAS
visual learning (GO:0008542) 5.922BRAF, KRAS
response to organic cyclic compound (GO:0014070) 3.072BRAF, KRAS
response to endogenous stimulus (GO:0009719) 2.792BRAF, KRAS
trachea formation (GO:0060440) 7.782MAP2K2, MAP2K1
proteolysis (GO:0006508) 2.732MAP2K2, MAP2K1
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562MAP2K2, MAP2K1
locomotion (GO:0040011) 2.912MAP2K1, KRAS
multicellular organismal process (GO:0032501) 1.452BRAF, KRAS
lung morphogenesis (GO:0060425) 6.552MAP2K2, MAP2K1
regulation of stress-activated protein kinase signaling cascade (GO:0070302) 4.442MAP2K2, MAP2K1
neurological system process (GO:0050877) 2.642BRAF, KRAS
regulation of cellular amide metabolic process (GO:0034248) 3.882MAP2K2, MAP2K1
regulation of stress-activated MAPK cascade (GO:0032872) 4.452MAP2K2, MAP2K1
regulation of cellular component movement (GO:0051270) 3.082MAP2K2, BRAF
positive regulation of transcription, DNA-templated (GO:0045893) 2.562MAP2K2, MAP2K1
response to hormone (GO:0009725) 3.332BRAF, KRAS
regulation of synaptic plasticity (GO:0048167) 4.782BRAF, KRAS
epithelial cell proliferation (GO:0050673) 5.212MAP2K2, MAP2K1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542MAP2K2, MAP2K1
regulation of vacuolar transport (GO:1903335) 6.362MAP2K2, MAP2K1
ERK1 and ERK2 cascade (GO:0070371) 6.642MAP2K2, MAP2K1
activation of MAPK activity (GO:0000187) 4.792MAP2K2, MAP2K1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32MAP2K2, MAP2K1
regulation of Golgi organization (GO:1903358) 7.242MAP2K2, MAP2K1
peptidyl-tyrosine phosphorylation (GO:0018108) 4.482MAP2K2, MAP2K1
regulation of cell death (GO:0010941) 2.432BRAF, KRAS
proteolysis in other organism (GO:0035897) 7.942MAP2K2, MAP2K1
cell proliferation (GO:0008283) 3.232MAP2K2, MAP2K1
regulation of programmed cell death (GO:0043067) 2.492BRAF, KRAS
negative regulation of apoptotic process (GO:0043066) 3.042BRAF, KRAS
negative regulation of programmed cell death (GO:0043069) 3.022BRAF, KRAS
epithelial cell proliferation involved in lung morphogenesis (GO:0060502) 8.632MAP2K2, MAP2K1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352MAP2K2, MAP2K1
regulation of gene silencing by RNA (GO:0060966) 6.552MAP2K2, MAP2K1
regulation of gene silencing by miRNA (GO:0060964) 6.682MAP2K2, MAP2K1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292MAP2K2, MAP2K1
response to chemical (GO:0042221) 1.982BRAF, KRAS
regulation of production of small RNA involved in gene silencing by RNA (GO:0070920) 7.432MAP2K2, MAP2K1
regulation of gene silencing (GO:0060968) 5.92MAP2K2, MAP2K1
organelle organization (GO:0006996) 2.022MAP2K1, KRAS
heart development (GO:0007507) 4.242MAP2K2, MAP2K1
regulation of locomotion (GO:0040012) 3.122MAP2K2, BRAF
single-organism organelle organization (GO:1902589) 2.682MAP2K1, KRAS
regulation of translation (GO:0006417) 3.962MAP2K2, MAP2K1

NET-GE enrichment

Term New enriched termICP valueGenes
positive regulation of response to stimulus (GO:0048584) -2.180.035MAP2K2, MAP2K1, KRAS, BRAF
activation of protein kinase activity (GO:0032147) -4.080.003MAP2K2, MAP2K1, KRAS, BRAF
enzyme linked receptor protein signaling pathway (GO:0007167) NEW3.240.001MAP2K2, MAP2K1, KRAS, BRAF
transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) NEW3.540.0MAP2K2, MAP2K1, KRAS, BRAF
signal transduction by phosphorylation (GO:0023014) -3.790.0MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of signal transduction (GO:0009967) -2.50.006MAP2K2, MAP2K1, KRAS, BRAF
MAPK cascade (GO:0000165) -3.910.0MAP2K2, MAP2K1, KRAS, BRAF
response to growth factor (GO:0070848) NEW4.140.001MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of molecular function (GO:0044093) -2.230.031MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of small GTPase mediated signal transduction (GO:0051057) NEW6.040.011MAP2K1, KRAS
neurotrophin signaling pathway (GO:0038179) NEW6.550.002MAP2K2, MAP2K1, KRAS, BRAF
regulation of protein kinase activity (GO:0045859) -3.150.001MAP2K2, MAP2K1, KRAS, BRAF
toll-like receptor 9 signaling pathway (GO:0034162) NEW7.020.047MAP2K2, MAP2K1
epidermal growth factor receptor signaling pathway (GO:0007173) NEW5.720.002MAP2K2, MAP2K1, KRAS
response to peptide hormone (GO:0043434) NEW4.060.0MAP2K2, MAP2K1, KRAS, BRAF
neuron projection guidance (GO:0097485) NEW4.430.016MAP2K2, MAP2K1, KRAS
regulation of phosphorylation (GO:0042325) -2.50.009MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of phosphorylation (GO:0042327) -2.90.002MAP2K2, MAP2K1, KRAS, BRAF
regulation of Golgi inheritance (GO:0090170) -8.340.0MAP2K2, MAP2K1
positive regulation of MAP kinase activity (GO:0043406) -4.390.002MAP2K2, MAP2K1, KRAS
response to organonitrogen compound (GO:0010243) NEW3.20.001MAP2K2, MAP2K1, KRAS, BRAF
visual behavior (GO:0007632) -5.820.021BRAF, KRAS
positive regulation of kinase activity (GO:0033674) -3.540.0MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of protein serine/threonine kinase activity (GO:0071902) -4.060.006MAP2K2, MAP2K1, KRAS
intracellular signal transduction (GO:0035556) -2.390.026MAP2K2, MAP2K1, KRAS, BRAF
regulation of protein serine/threonine kinase activity (GO:0071900) -3.580.025MAP2K2, MAP2K1, KRAS
positive regulation of transferase activity (GO:0051347) -3.310.0MAP2K2, MAP2K1, KRAS, BRAF
fibroblast growth factor receptor signaling pathway (GO:0008543) NEW5.30.0MAP2K2, MAP2K1, KRAS, BRAF
regulation of kinase activity (GO:0043549) -3.070.001MAP2K2, MAP2K1, KRAS, BRAF
cellular response to fibroblast growth factor stimulus (GO:0044344) NEW6.40.0MAP2K2, MAP2K1, KRAS, BRAF
regulation of defense response (GO:0031347) NEW3.110.038MAP2K2, MAP2K1, KRAS, BRAF
regulation of early endosome to late endosome transport (GO:2000641) -6.960.003MAP2K2, MAP2K1
positive regulation of MAPK cascade (GO:0043410) -3.570.013MAP2K2, MAP2K1, KRAS, BRAF
toll-like receptor 5 signaling pathway (GO:0034146) NEW9.730.038MAP2K2, MAP2K1
associative learning (GO:0008306) -5.440.037BRAF, KRAS
neurotrophin TRK receptor signaling pathway (GO:0048011) NEW6.960.0MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of intracellular signal transduction (GO:1902533) -2.950.001MAP2K2, MAP2K1, KRAS, BRAF
regulation of intracellular signal transduction (GO:1902531) -2.310.011MAP2K2, MAP2K1, KRAS, BRAF
Fc-epsilon receptor signaling pathway (GO:0038095) NEW4.840.008MAP2K2, MAP2K1, KRAS
Fc receptor signaling pathway (GO:0038093) NEW4.450.014MAP2K2, MAP2K1, KRAS
response to nitrogen compound (GO:1901698) NEW3.120.001MAP2K2, MAP2K1, KRAS, BRAF
cellular response to nitrogen compound (GO:1901699) NEW3.790.028MAP2K2, MAP2K1, KRAS
regulation of transferase activity (GO:0051338) -2.880.002MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of cell motility (GO:2000147) NEW3.740.007MAP2K2, MAP2K1, KRAS, BRAF
response to fibroblast growth factor (GO:0071774) NEW6.170.0MAP2K2, MAP2K1, KRAS, BRAF
phosphorylation (GO:0016310) -2.630.008MAP2K2, MAP2K1, KRAS, BRAF
regulation of cell adhesion (GO:0030155) NEW3.270.012MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of Ras protein signal transduction (GO:0046579) NEW6.20.008MAP2K1, KRAS
stress-activated protein kinase signaling cascade (GO:0031098) NEW5.410.004MAP2K2, MAP2K1, KRAS
positive regulation of signaling (GO:0023056) -2.410.007MAP2K2, MAP2K1, KRAS, BRAF
toll-like receptor TLR1:TLR2 signaling pathway (GO:0038123) NEW8.630.046MAP2K2, MAP2K1
regulation of MAP kinase activity (GO:0043405) -3.950.007MAP2K2, MAP2K1, KRAS
ERBB signaling pathway (GO:0038127) NEW5.360.002MAP2K2, MAP2K1, KRAS
toll-like receptor TLR6:TLR2 signaling pathway (GO:0038124) NEW8.340.046MAP2K2, MAP2K1
axon guidance (GO:0007411) NEW4.440.016MAP2K2, MAP2K1, KRAS
positive regulation of cell communication (GO:0010647) -2.410.007MAP2K2, MAP2K1, KRAS, BRAF
regulation of GTPase activity (GO:0043087) NEW3.210.037MAP2K2, MAP2K1, KRAS, BRAF
visual learning (GO:0008542) -5.920.017BRAF, KRAS
positive regulation of catalytic activity (GO:0043085) -2.40.017MAP2K2, MAP2K1, KRAS, BRAF
regulation of MAPK cascade (GO:0043408) -3.220.0MAP2K2, MAP2K1, KRAS, BRAF
response to endogenous stimulus (GO:0009719) -2.790.011MAP2K2, MAP2K1, KRAS, BRAF
cellular response to peptide hormone stimulus (GO:0071375) NEW4.630.006MAP2K2, MAP2K1, KRAS
positive regulation of substrate adhesion-dependent cell spreading (GO:1900026) NEW6.40.037BRAF, KRAS
positive regulation of phosphorus metabolic process (GO:0010562) -2.780.003MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of protein metabolic process (GO:0051247) -2.430.006MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of cellular protein metabolic process (GO:0032270) -2.490.004MAP2K2, MAP2K1, KRAS, BRAF
regulation of Golgi organization (GO:1903358) -7.240.0MAP2K2, MAP2K1
cellular response to endogenous stimulus (GO:0071495) NEW3.330.003MAP2K2, MAP2K1, KRAS, BRAF
insulin receptor signaling pathway (GO:0008286) NEW5.330.001MAP2K2, MAP2K1, KRAS
regulation of protein modification process (GO:0031399) -2.320.011MAP2K2, MAP2K1, KRAS, BRAF
regulation of vesicle-mediated transport (GO:0060627) -3.630.008MAP2K2, MAP2K1, KRAS, BRAF
cellular response to hormone stimulus (GO:0032870) NEW3.990.033MAP2K2, MAP2K1, KRAS
regulation of cellular protein metabolic process (GO:0032268) -1.990.028MAP2K2, MAP2K1, KRAS, BRAF
cellular response to growth factor stimulus (GO:0071363) NEW4.270.0MAP2K2, MAP2K1, KRAS, BRAF
response to hormone (GO:0009725) -3.330.002MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of protein kinase activity (GO:0045860) -3.610.044MAP2K2, MAP2K1, KRAS, BRAF
activation of MAPKK activity (GO:0000186) NEW5.740.0MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of protein modification process (GO:0031401) -2.70.002MAP2K2, MAP2K1, KRAS, BRAF
toll-like receptor 2 signaling pathway (GO:0034134) NEW7.940.048MAP2K2, MAP2K1
cellular response to insulin stimulus (GO:0032869) NEW5.290.002MAP2K2, MAP2K1, KRAS
response to insulin (GO:0032868) NEW4.720.005MAP2K2, MAP2K1, KRAS
cellular response to organonitrogen compound (GO:0071417) NEW3.870.023MAP2K2, MAP2K1, KRAS
cellular response to organic substance (GO:0071310) NEW2.780.036MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of phosphate metabolic process (GO:0045937) -2.780.003MAP2K2, MAP2K1, KRAS, BRAF
stress-activated MAPK cascade (GO:0051403) NEW5.450.004MAP2K2, MAP2K1, KRAS
Ras protein signal transduction (GO:0007265) NEW4.760.001MAP2K2, MAP2K1, KRAS, BRAF
small GTPase mediated signal transduction (GO:0007264) NEW3.850.017MAP2K2, MAP2K1, KRAS, BRAF
response to oxygen-containing compound (GO:1901700) NEW2.570.008MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of cellular component movement (GO:0051272) NEW3.710.008MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of locomotion (GO:0040017) NEW3.710.01MAP2K2, MAP2K1, KRAS, BRAF
response to peptide (GO:1901652) NEW3.940.017MAP2K2, MAP2K1, KRAS, BRAF
cellular response to peptide (GO:1901653) NEW4.520.007MAP2K2, MAP2K1, KRAS
immune response-regulating cell surface receptor signaling pathway (GO:0002768) NEW3.960.031MAP2K2, MAP2K1, KRAS
toll-like receptor 10 signaling pathway (GO:0034166) NEW9.730.038MAP2K2, MAP2K1
regulation of protein phosphorylation (GO:0001932) -2.570.004MAP2K2, MAP2K1, KRAS, BRAF
positive regulation of protein phosphorylation (GO:0001934) -2.950.001MAP2K2, MAP2K1, KRAS, BRAF
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.014MAP2K2, MAP2K1, KRAS, BRAF
intracellular membrane-bounded organelle (GO:0043231) 0.64MAP2K2, MAP2K1, KRAS, BRAF
cytosol (GO:0005829) 1.684MAP2K2, MAP2K1, KRAS, BRAF
membrane (GO:0016020) 0.684MAP2K2, MAP2K1, KRAS, BRAF
cell part (GO:0044464) 0.114MAP2K2, MAP2K1, KRAS, BRAF
cytoplasmic part (GO:0044444) 0.824MAP2K2, MAP2K1, KRAS, BRAF
mitochondrion (GO:0005739) 2.424MAP2K2, MAP2K1, KRAS, BRAF
intracellular organelle (GO:0043229) 0.514MAP2K2, MAP2K1, KRAS, BRAF
intracellular part (GO:0044424) 0.284MAP2K2, MAP2K1, KRAS, BRAF
membrane-bounded organelle (GO:0043227) 0.474MAP2K2, MAP2K1, KRAS, BRAF
organelle (GO:0043226) 0.44MAP2K2, MAP2K1, KRAS, BRAF
nucleus (GO:0005634) 1.073MAP2K2, MAP2K1, BRAF
anchoring junction (GO:0070161) 3.613MAP2K2, MAP2K1, KRAS
adherens junction (GO:0005912) 3.663MAP2K2, MAP2K1, KRAS
plasma membrane (GO:0005886) 1.393MAP2K1, BRAF, KRAS
cell-substrate adherens junction (GO:0005924) 3.833MAP2K2, MAP2K1, KRAS
focal adhesion (GO:0005925) 3.833MAP2K2, MAP2K1, KRAS
cell junction (GO:0030054) 2.753MAP2K2, MAP2K1, KRAS
cell-substrate junction (GO:0030055) 3.823MAP2K2, MAP2K1, KRAS
Golgi apparatus (GO:0005794) 2.72MAP2K2, MAP2K1
endoplasmic reticulum (GO:0005783) 2.562MAP2K2, MAP2K1
vacuole (GO:0005773) 2.922MAP2K2, MAP2K1
endosome (GO:0005768) 3.252MAP2K2, MAP2K1
late endosome (GO:0005770) 4.852MAP2K2, MAP2K1
intracellular organelle part (GO:0044446) 0.812MAP2K2, MAP2K1
cytoskeletal part (GO:0044430) 2.492MAP2K2, MAP2K1
membrane part (GO:0044425) 0.952MAP2K2, KRAS
plasma membrane part (GO:0044459) 1.952MAP2K2, KRAS
early endosome (GO:0005769) 4.342MAP2K2, MAP2K1
organelle part (GO:0044422) 0.792MAP2K2, MAP2K1

NET-GE enrichment

Term New enriched termICP valueGenes
anchoring junction (GO:0070161) -3.610.002MAP2K2, MAP2K1, KRAS, BRAF
adherens junction (GO:0005912) -3.660.001MAP2K2, MAP2K1, KRAS, BRAF
late endosome (GO:0005770) -4.850.013MAP2K2, MAP2K1
mitochondrion (GO:0005739) -2.420.001MAP2K2, MAP2K1, KRAS, BRAF
cell cortex (GO:0005938) NEW4.780.014MAP2K2, MAP2K1
cell-substrate adherens junction (GO:0005924) -3.830.001MAP2K2, MAP2K1, KRAS, BRAF
focal adhesion (GO:0005925) -3.830.002MAP2K2, MAP2K1, KRAS, BRAF
early endosome (GO:0005769) -4.340.008MAP2K2, MAP2K1, KRAS
cell junction (GO:0030054) -2.750.042MAP2K2, MAP2K1, KRAS
cell-substrate junction (GO:0030055) -3.820.002MAP2K2, MAP2K1, KRAS, BRAF