Gene table of BRAF : B-Raf proto-oncogene, serine/threonine kinase

Gene-disease associations table

Disease IDDisease nameSource of annotation with BRAFOMIM linkNumber of associated genesgenes
PS163950NOONAN SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 9LZTR1, BRAF, RIT1, NRAS, KRAS, SOS2, PTPN11, SOS1, RAF1
211980LUNG CANCEROMIM, HUMSAVAR link to OMIM 17RASSF1, PARK2, IRF1, DLEC1, ERBB2, CYP2A6, PPP2R1B, MAP3K8, PIK3CA, BRAF, KRAS, SLC22A18, ERCC6, FASLG, CASP8, MXRA5, EGFR
PS115150CARDIOFACIOCUTANEOUS SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 4KRAS, BRAF, MAP2K1, MAP2K2
PS188550THYROID CANCER, NONMEDULLARYClinVar link to OMIM 4NKX2-1, BRAF, FOXE1, HABP2
PS151100LEOPARD SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 3RAF1, BRAF, PTPN11
PS155600MELANOMA, CUTANEOUS MALIGNANTOMIM link to OMIM 11STK11, POT1, BRAF, TERT, PTEN, CDKN2A, MITF, TYR, MC1R, CDK4, XRCC3
605027LYMPHOMA, NON-HODGKIN, FAMILIALClinVar, HUMSAVAR link to OMIM 7RAD54B, BRAF, BCL10, TP53, CASP10, PRF1, RAD54L
114500COLORECTAL CANCEROMIM, HUMSAVAR link to OMIM 30TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B

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Annotation of the gene BRAF

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Melanomahsa052186.56
Bladder cancerhsa052197.38
Focal adhesionhsa045104.92
Pancreatic cancerhsa052126.56
Natural killer cell mediated cytotoxicityhsa046505.53
Colorectal cancerhsa052106.52
Renal cell carcinomahsa052116.6
Thyroid cancerhsa052167.48
Gliomahsa052146.66
Prostate cancerhsa052156.11
Long-term potentiationhsa047206.64
Neurotrophin signaling pathwayhsa047225.78
FoxO signaling pathwayhsa040685.63
Serotonergic synapsehsa047265.84
Chemokine signaling pathwayhsa040625.19
Progesterone-mediated oocyte maturationhsa049146.18
Long-term depressionhsa047306.74
Endometrial cancerhsa052136.81
Hepatitis Chsa051605.68
Vascular smooth muscle contractionhsa042705.74
Proteoglycans in cancerhsa052055.02
Pathways in cancerhsa052003.98
Insulin signaling pathwayhsa049105.55
Non-small cell lung cancerhsa052236.88
ErbB signaling pathwayhsa040126.15
Acute myeloid leukemiahsa052216.74
Chronic myeloid leukemiahsa052206.48
mTOR signaling pathwayhsa041506.72
Regulation of actin cytoskeletonhsa048104.9
MAPK signaling pathwayhsa040104.63
Rap1 signaling pathwayhsa040154.97
cAMP signaling pathwayhsa040245.05
Alcoholismhsa050345.59
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
NCAM signaling for neurite out-growthR-HSA-3751654.9
Signaling by InterleukinsR-HSA-4491474.71
Signaling by LeptinR-HSA-25865525.1
Frs2-mediated activationR-HSA-1709685.12
MAP2K and MAPK activationR-HSA-56741357.66
Cytokine Signaling in Immune systemR-HSA-12802153.74
IGF1R signaling cascadeR-HSA-24289244.85
Downstream signal transductionR-HSA-1867634.65
Post NMDA receptor activation eventsR-HSA-4380647.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by ERBB4R-HSA-12363944.7
IRS-mediated signallingR-HSA-1123994.87
MAPK1/MAPK3 signalingR-HSA-56849965.11
CREB phosphorylation through the activation of RasR-HSA-4427428.23
RAF activationR-HSA-56730008.34
RAF/MAP kinase cascadeR-HSA-56730015.15
Negative regulation of FGFR2 signalingR-HSA-56547277.89
Downstream signaling of activated FGFR1R-HSA-56546874.71
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
Signaling by VEGFR-HSA-1941384.66
Signalling to p38 via RIT and RINR-HSA-1877065.12
FCERI mediated MAPK activationR-HSA-28717964.32
Negative regulation of FGFR1 signalingR-HSA-56547267.98
Signaling by EGFRR-HSA-1779294.59
FRS-mediated FGFR2 signalingR-HSA-56547005.14
SOS-mediated signallingR-HSA-1124125.15
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Developmental BiologyR-HSA-12667383.48
Signaling by Insulin receptorR-HSA-747524.73
Neuronal SystemR-HSA-1123164.82
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellR-HSA-1123145.85
Transmission across Chemical SynapsesR-HSA-1123155.28
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Interleukin receptor SHC signalingR-HSA-9125265.09
Signaling by FGFRR-HSA-1902364.67
Spry regulation of FGF signalingR-HSA-12955969.18
Downstream signaling of activated FGFR3R-HSA-56547084.71
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Immune SystemR-HSA-1682562.37
Downstream signaling of activated FGFR4R-HSA-56547164.71
Innate Immune SystemR-HSA-1682493.17
Signaling by SCF-KITR-HSA-14335574.73
Interleukin-2 signalingR-HSA-4519275.05
SHC1 events in ERBB2 signalingR-HSA-12501965.15
Signaling by ERBB2R-HSA-12279864.66
Signalling to RASR-HSA-1670445.08
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Negative feedback regulation of MAPK pathwayR-HSA-567449910.4
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsR-HSA-4427557.7
Downstream signaling of activated FGFR2R-HSA-56546964.71
Signaling by FGFR1R-HSA-56547364.69
SHC1 events in EGFR signalingR-HSA-1803365.15
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Prolonged ERK activation eventsR-HSA-1698935.11
Negative regulation of MAPK pathwayR-HSA-56752217.66
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Signaling by GPCRR-HSA-3727902.68
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signalling to ERKsR-HSA-1876875.04
Negative regulation of FGFR4 signalingR-HSA-56547338.03
Negative regulation of FGFR3 signalingR-HSA-56547328.12
ARMS-mediated activationR-HSA-1709845.12
Insulin receptor signalling cascadeR-HSA-747514.85
DAP12 interactionsR-HSA-21721274.56
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Axon guidanceR-HSA-4224753.93
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
purine ribonucleoside triphosphate bindingGO:00356392.22
enzyme bindingGO:00198992.27
small GTPase bindingGO:00312674.13
GTPase bindingGO:00510204.05
bindingGO:00054880.18
signal transducer activityGO:00048712.28
nucleotide bindingGO:00001661.96
heterocyclic compound bindingGO:19013631.06
purine nucleoside bindingGO:00018832.22
nucleoside bindingGO:00018822.21
cation bindingGO:00431691.4
mitogen-activated protein kinase kinase bindingGO:00314346.97
receptor signaling protein activityGO:00050574.76
ion bindingGO:00431671.36
protein serine/threonine kinase activityGO:00046743.64
transferase activityGO:00167401.95
calcium ion bindingGO:00055093.17
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
protein kinase activityGO:00046723.27
metal ion bindingGO:00468721.41
identical protein bindingGO:00428022.63
kinase activityGO:00163012.93
nucleoside phosphate bindingGO:19012651.96
protein kinase bindingGO:00199013.44
kinase bindingGO:00199003.32
receptor signaling protein serine/threonine kinase activityGO:00047025.23
small molecule bindingGO:00360941.89
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
catalytic activityGO:00038241.05
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
adenyl ribonucleotide bindingGO:00325592.41
ATP bindingGO:00055242.43
protein bindingGO:00055150.46
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
purine ribonucleotide bindingGO:00325552.2
protein dimerization activityGO:00469832.72
protein heterodimerization activityGO:00469823.64
MAP kinase kinase kinase activityGO:00047096.6
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19