Gene table of MPL : MPL proto-oncogene, thrombopoietin receptor

Gene-disease associations table

Disease IDDisease nameSource of annotation with MPLOMIM linkNumber of associated genesgenes
254450MYELOFIBROSISOMIM, HUMSAVAR link to OMIM 4SH2B3, JAK2, MPL, CALR
604498AMEGAKARYOCYTIC THROMBOCYTOPENIA, CONGENITALClinVar, OMIM, HUMSAVAR link to OMIM 1MPL
PS187950THROMBOCYTHEMIAClinVar, OMIM, HUMSAVAR link to OMIM 5SH2B3, JAK2, MPL, THPO, CALR

Download the gene annotation in CSV format

Annotation of the gene MPL

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Cytokine-cytokine receptor interactionhsa040604.67
Jak-STAT signaling pathwayhsa046305.44
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Platelet Aggregation (Plug Formation)R-HSA-760097.77
Platelet activation, signaling and aggregationR-HSA-760025.15
HemostasisR-HSA-1095823.98
Associated GO terms for Molecular function
GO termGO IDGO IC
bindingGO:00054880.18
signaling receptor activityGO:00380232.49
signal transducer activityGO:00048712.28
thrombopoietin receptor activityGO:00381649.74
molecular transducer activityGO:00600892.32
transmembrane signaling receptor activityGO:00048882.57
receptor activityGO:00048722.32
protein bindingGO:00055150.46
transmembrane receptor activityGO:00996002.53
cytokine receptor activityGO:00048965.24