Disease table of THROMBOCYTHEMIA OMIM ID: PS187950

Gene-disease associations table

Gene	Associated with THROMBOCYTHEMIA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
CALR	OMIM	HGNC link	19p13.13	2	PS187950, 254450
THPO	ClinVar, OMIM	HGNC link	3q27.1	1	PS187950
JAK2	ClinVar, OMIM, HUMSAVAR	HGNC link	9p24.1	5	263300, 601626, 254450, PS133100, PS187950
MPL	ClinVar, OMIM, HUMSAVAR	HGNC link	1p34.2	3	PS187950, 254450, 604498
SH2B3	ClinVar, OMIM	HGNC link	12q24.12	3	PS187950, 254450, PS133100

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs
CALR	YES	1	MEF2C
JAK2	YES	3	BRCA1, STAT3, STAT1
MPL	YES	4	GATA1, RUNX1, FLI1, PLAGL2

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CALR	JAK2	No	5	SLC2A1, TSHR, EGFR, HSP90AB1, RCN1
CALR	SH2B3	No	2	ELAVL1, EGFR
JAK2	MPL	No	1	SOCS1
JAK2	SH2B3	No	5	EGFR, ERBB2, ERBB3, PLCG1, GRB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
CALR	JAK2	No	-	4	UBC, ITGA3, INSR, HSP90AA1
THPO	JAK2	Yes	activation, binding	11	STAT5B, BCL2L1, PIK3R1, PLCG1, STAT3, MPL, STAT5A, PIK3CA, SOS1, SHC1, GRB2
THPO	MPL	Yes	binding	10	STAT3, PIK3R1, PLCG1, STAT5A, SOS1, JAK2, STAT5B, PIK3CA, SHC1, GRB2
THPO	SH2B3	No	-	2	GRB2, JAK2
JAK2	MPL	Yes	activation, binding	57	PLCG1, OSM, PRL, IL12A, IFNA5, IFNG, EPO, JAK1, THPO, SOCS2, IL24, CSF2, IL7, IFNA14, IL4, GH1, SOCS4, IL6, PIK3CA, SOCS3, IFNA17, IFNA10, IFNA7, SOS1, IFNA2, SHC1, IL11, IL19, IFNA21, STAT5A, IFNB1, IFNA1, IL2, CSH2, CSF3, IFNA6, STAT5B, IFNA13, CSH1, CBLB, SOCS1, IFNA4, IFNA16, STAT3, GH2, SOCS7, IL3, IL23A, SOCS5, CBLC, IL5, PIK3R1, IFNA8, TYK2, GRB2, LEP, CBL
JAK2	SH2B3	Yes	binding	8	KIT, KITLG, LCK, SH2B1, SOCS3, EPO, GRB2, EPOR
MPL	SH2B3	No	-	4	EPO, GRB2, SOCS3, JAK2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Jak-STAT signaling pathway	hsa04630	5.44	3	THPO, JAK2, MPL
Cytokine-cytokine receptor interaction	hsa04060	4.67	2	THPO, MPL

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Hematopoietic cell lineage (hsa04640)	NEW	6.18	0.012	CALR, THPO, JAK2
Jak-STAT signaling pathway (hsa04630)	-	5.44	0.004	THPO, JAK2, MPL

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Hemostasis	R-HSA-109582	3.98	4	THPO, SH2B3, JAK2, MPL
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	3	THPO, JAK2, MPL
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.77	2	THPO, MPL
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.88	2	SH2B3, JAK2
Immune System	R-HSA-168256	2.37	2	CALR, JAK2
Signaling by SCF-KIT	R-HSA-1433557	4.73	2	SH2B3, JAK2
Signal Transduction	R-HSA-162582	1.78	2	SH2B3, JAK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Platelet Aggregation (Plug Formation) (R-HSA-76009)	-	7.77	0.022	THPO, MPL
Platelet activation, signaling and aggregation (R-HSA-76002)	-	5.15	0.006	THPO, CALR, MPL, JAK2
Hemostasis (R-HSA-109582)	-	3.98	0.008	THPO, CALR, SH2B3, MPL, JAK2

GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	5	THPO, CALR, SH2B3, JAK2, MPL
protein binding (GO:0005515)	0.46	5	THPO, CALR, SH2B3, JAK2, MPL
receptor binding (GO:0005102)	2.43	3	CALR, THPO, JAK2
cation binding (GO:0043169)	1.4	2	CALR, JAK2
carbohydrate derivative binding (GO:0097367)	2.03	2	CALR, JAK2
organic cyclic compound binding (GO:0097159)	1.05	2	CALR, JAK2
enzyme binding (GO:0019899)	2.27	2	CALR, JAK2
ion binding (GO:0043167)	1.36	2	CALR, JAK2
signal transducer activity (GO:0004871)	2.28	2	SH2B3, MPL
hormone receptor binding (GO:0051427)	4.57	2	CALR, JAK2
metal ion binding (GO:0046872)	1.41	2	CALR, JAK2
heterocyclic compound binding (GO:1901363)	1.06	2	CALR, JAK2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
regulation of cellular process (GO:0050794)	0.5	5	THPO, CALR, SH2B3, JAK2, MPL
biological regulation (GO:0065007)	0.39	5	THPO, CALR, SH2B3, JAK2, MPL
regulation of biological process (GO:0050789)	0.45	5	THPO, CALR, SH2B3, JAK2, MPL
single-organism process (GO:0044699)	0.48	5	THPO, CALR, SH2B3, JAK2, MPL
signal transduction (GO:0007165)	1.28	5	THPO, CALR, SH2B3, JAK2, MPL
developmental process (GO:0032502)	1.36	4	CALR, SH2B3, THPO, JAK2
cell differentiation (GO:0030154)	2.14	4	CALR, SH2B3, THPO, JAK2
regulation of signal transduction (GO:0009966)	1.84	4	CALR, SH2B3, THPO, JAK2
cellular developmental process (GO:0048869)	1.82	4	CALR, SH2B3, THPO, JAK2
positive regulation of response to stimulus (GO:0048584)	2.18	4	CALR, SH2B3, THPO, JAK2
regulation of response to stimulus (GO:0048583)	1.54	4	CALR, SH2B3, THPO, JAK2
single-organism developmental process (GO:0044767)	1.49	4	CALR, SH2B3, THPO, JAK2
single-organism cellular process (GO:0044763)	0.65	4	CALR, SH2B3, THPO, JAK2
regulation of signaling (GO:0023051)	1.72	4	CALR, SH2B3, THPO, JAK2
positive regulation of biological process (GO:0048518)	1.2	4	CALR, SH2B3, THPO, JAK2
cellular process (GO:0009987)	0.26	4	CALR, SH2B3, THPO, JAK2
regulation of cell communication (GO:0010646)	1.73	4	CALR, SH2B3, THPO, JAK2
positive regulation of cellular process (GO:0048522)	1.3	4	CALR, SH2B3, THPO, JAK2
regulation of cell proliferation (GO:0042127)	2.41	3	CALR, THPO, JAK2
positive regulation of metabolic process (GO:0009893)	1.74	3	CALR, THPO, JAK2
regulation of metabolic process (GO:0019222)	1.02	3	CALR, THPO, JAK2
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	CALR, THPO, JAK2
regulation of cellular metabolic process (GO:0031323)	1.07	3	CALR, THPO, JAK2
positive regulation of signaling (GO:0023056)	2.41	3	THPO, SH2B3, JAK2
cell surface receptor signaling pathway (GO:0007166)	2.09	3	THPO, JAK2, MPL
positive regulation of cell communication (GO:0010647)	2.41	3	THPO, SH2B3, JAK2
regulation of primary metabolic process (GO:0080090)	1.08	3	CALR, THPO, JAK2
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	CALR, THPO, JAK2
positive regulation of signal transduction (GO:0009967)	2.5	3	THPO, SH2B3, JAK2
regulation of protein metabolic process (GO:0051246)	1.93	3	CALR, THPO, JAK2
regulation of immune system process (GO:0002682)	2.5	3	CALR, THPO, JAK2
regulation of biological quality (GO:0065008)	1.68	3	CALR, SH2B3, JAK2
cytokine-mediated signaling pathway (GO:0019221)	3.6	3	THPO, JAK2, MPL
positive regulation of cell proliferation (GO:0008284)	3.01	3	CALR, THPO, JAK2
multicellular organismal process (GO:0032501)	1.45	3	THPO, SH2B3, JAK2
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	CALR, THPO, JAK2
positive regulation of cell differentiation (GO:0045597)	3.01	3	CALR, THPO, JAK2
regulation of cell differentiation (GO:0045595)	2.42	3	CALR, THPO, JAK2
regulation of multicellular organismal process (GO:0051239)	1.87	3	CALR, THPO, JAK2
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	CALR, THPO, JAK2
single-multicellular organism process (GO:0044707)	1.78	3	THPO, SH2B3, JAK2
anatomical structure development (GO:0048856)	1.58	3	THPO, SH2B3, JAK2
nuclear transport (GO:0051169)	4.2	2	CALR, JAK2
protein localization (GO:0008104)	2.36	2	CALR, JAK2
hemostasis (GO:0007599)	4.5	2	SH2B3, JAK2
regulation of transport (GO:0051049)	2.24	2	CALR, JAK2
blood coagulation (GO:0007596)	4.52	2	SH2B3, JAK2
thrombopoietin-mediated signaling pathway (GO:0038163)	8.63	2	THPO, MPL
calcium ion homeostasis (GO:0055074)	3.97	2	CALR, JAK2
inorganic ion homeostasis (GO:0098771)	3.43	2	CALR, JAK2
regulation of phosphate metabolic process (GO:0019220)	2.35	2	THPO, JAK2
cellular component organization or biogenesis (GO:0071840)	1.22	2	CALR, JAK2
hormone-mediated signaling pathway (GO:0009755)	4.66	2	CALR, JAK2
cellular response to stimulus (GO:0051716)	1.97	2	CALR, JAK2
positive regulation of cell adhesion (GO:0045785)	3.79	2	CALR, JAK2
negative regulation of biological process (GO:0048519)	1.33	2	CALR, JAK2
intracellular steroid hormone receptor signaling pathway (GO:0030518)	5.47	2	CALR, JAK2
macromolecule localization (GO:0033036)	2.34	2	CALR, JAK2
ion homeostasis (GO:0050801)	3.42	2	CALR, JAK2
cellular homeostasis (GO:0019725)	3.23	2	CALR, JAK2
positive regulation of transport (GO:0051050)	2.9	2	CALR, JAK2
establishment of protein localization (GO:0045184)	2.53	2	CALR, JAK2
regulation of RNA biosynthetic process (GO:2001141)	1.55	2	CALR, JAK2
response to organic substance (GO:0010033)	2.2	2	CALR, JAK2
regulation of phosphorylation (GO:0042325)	2.5	2	THPO, JAK2
positive regulation of phosphorylation (GO:0042327)	2.9	2	THPO, JAK2
protein metabolic process (GO:0019538)	1.45	2	CALR, JAK2
chemical homeostasis (GO:0048878)	2.97	2	CALR, JAK2
immune system process (GO:0002376)	2.29	2	CALR, JAK2
positive regulation of cellular component movement (GO:0051272)	3.71	2	CALR, JAK2
cellular response to stress (GO:0033554)	2.51	2	CALR, JAK2
cellular component assembly (GO:0022607)	2.14	2	CALR, JAK2
corticosteroid receptor signaling pathway (GO:0031958)	7.43	2	CALR, JAK2
positive regulation of biosynthetic process (GO:0009891)	2.29	2	CALR, JAK2
intracellular signal transduction (GO:0035556)	2.39	2	SH2B3, JAK2
regulation of apoptotic process (GO:0042981)	2.5	2	CALR, JAK2
intracellular protein transport (GO:0006886)	3.2	2	CALR, JAK2
cellular component organization (GO:0016043)	1.24	2	CALR, JAK2
macromolecular complex assembly (GO:0065003)	2.55	2	CALR, JAK2
regulation of cell-substrate adhesion (GO:0010810)	4.56	2	CALR, JAK2
positive regulation of immune system process (GO:0002684)	2.96	2	CALR, THPO
cellular protein localization (GO:0034613)	3.11	2	CALR, JAK2
regulation of developmental process (GO:0050793)	2.1	2	CALR, THPO
transport (GO:0006810)	1.51	2	CALR, JAK2
regulation of biosynthetic process (GO:0009889)	1.37	2	CALR, JAK2
positive regulation of MAPK cascade (GO:0043410)	3.57	2	THPO, JAK2
response to stress (GO:0006950)	1.8	2	CALR, JAK2
coagulation (GO:0050817)	4.51	2	SH2B3, JAK2
metabolic process (GO:0008152)	0.58	2	CALR, JAK2
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	THPO, JAK2
regulation of intracellular signal transduction (GO:1902531)	2.31	2	THPO, JAK2
intracellular transport (GO:0046907)	2.67	2	CALR, JAK2
response to stimulus (GO:0050896)	1.22	2	CALR, JAK2
positive regulation of protein modification process (GO:0031401)	2.7	2	THPO, JAK2
regulation of transcription, DNA-templated (GO:0006355)	1.56	2	CALR, JAK2
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	2	CALR, JAK2
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	2	CALR, JAK2
regulation of cell motility (GO:2000145)	3.16	2	CALR, JAK2
positive regulation of cell motility (GO:2000147)	3.74	2	CALR, JAK2
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	THPO, JAK2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	CALR, JAK2
positive regulation of response to external stimulus (GO:0032103)	4.17	2	CALR, JAK2
regulation of response to external stimulus (GO:0032101)	3.06	2	CALR, JAK2
regulation of cell adhesion (GO:0030155)	3.27	2	CALR, JAK2
metal ion homeostasis (GO:0055065)	3.61	2	CALR, JAK2
steroid hormone mediated signaling pathway (GO:0043401)	4.9	2	CALR, JAK2
regulation of MAPK cascade (GO:0043408)	3.22	2	THPO, JAK2
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	CALR, JAK2
establishment of localization (GO:0051234)	1.48	2	CALR, JAK2
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	CALR, JAK2
establishment of localization in cell (GO:0051649)	2.47	2	CALR, JAK2
positive regulation of multicellular organismal process (GO:0051240)	2.49	2	THPO, JAK2
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	CALR, JAK2
positive regulation of protein metabolic process (GO:0051247)	2.43	2	THPO, JAK2
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	THPO, JAK2
regulation of protein modification process (GO:0031399)	2.32	2	THPO, JAK2
regulation of body fluid levels (GO:0050878)	3.76	2	SH2B3, JAK2
cell proliferation (GO:0008283)	3.23	2	THPO, MPL
cellular metal ion homeostasis (GO:0006875)	3.75	2	CALR, JAK2
cellular calcium ion homeostasis (GO:0006874)	4.01	2	CALR, JAK2
cellular ion homeostasis (GO:0006873)	3.57	2	CALR, JAK2
regulation of locomotion (GO:0040012)	3.12	2	CALR, JAK2
cellular cation homeostasis (GO:0030003)	3.6	2	CALR, JAK2
cation homeostasis (GO:0055080)	3.46	2	CALR, JAK2
cellular chemical homeostasis (GO:0055082)	3.4	2	CALR, JAK2
regulation of localization (GO:0032879)	1.94	2	CALR, JAK2
positive regulation of developmental process (GO:0051094)	2.77	2	CALR, THPO
regulation of RNA metabolic process (GO:0051252)	1.52	2	CALR, JAK2
macromolecule metabolic process (GO:0043170)	0.83	2	CALR, JAK2
myeloid cell differentiation (GO:0030099)	4.63	2	THPO, JAK2
protein localization to organelle (GO:0033365)	3.57	2	CALR, JAK2
protein localization to nucleus (GO:0034504)	4.9	2	CALR, JAK2
chemokine-mediated signaling pathway (GO:0070098)	5.47	2	THPO, MPL
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	2	CALR, JAK2
macromolecular complex subunit organization (GO:0043933)	2.14	2	CALR, JAK2
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	CALR, JAK2
homeostatic process (GO:0042592)	2.61	2	CALR, JAK2
cellular macromolecular complex assembly (GO:0034622)	3.18	2	CALR, JAK2
regulation of cell death (GO:0010941)	2.43	2	CALR, JAK2
intracellular receptor signaling pathway (GO:0030522)	4.6	2	CALR, JAK2
protein complex subunit organization (GO:0071822)	2.6	2	CALR, JAK2
response to lipid (GO:0033993)	3.11	2	CALR, JAK2
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	2	CALR, JAK2
organic substance metabolic process (GO:0071704)	0.63	2	CALR, JAK2
regulation of programmed cell death (GO:0043067)	2.49	2	CALR, JAK2
organic substance transport (GO:0071702)	2.15	2	CALR, JAK2
regulation of gene expression (GO:0010468)	1.37	2	CALR, JAK2
positive regulation of cell migration (GO:0030335)	3.77	2	CALR, JAK2
regulation of cell migration (GO:0030334)	3.23	2	CALR, JAK2
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	THPO, JAK2
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	CALR, JAK2
positive regulation of cell-substrate adhesion (GO:0010811)	5.11	2	CALR, JAK2
protein complex assembly (GO:0006461)	2.78	2	CALR, JAK2
nucleocytoplasmic transport (GO:0006913)	4.23	2	CALR, JAK2
regulation of phosphorus metabolic process (GO:0051174)	2.35	2	THPO, JAK2
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	2	CALR, JAK2
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	2	CALR, JAK2
response to chemical (GO:0042221)	1.98	2	CALR, JAK2
cellular protein complex assembly (GO:0043623)	3.9	2	CALR, JAK2
localization (GO:0051179)	1.4	2	CALR, JAK2
cellular localization (GO:0051641)	2.32	2	CALR, JAK2
response to oxygen-containing compound (GO:1901700)	2.57	2	CALR, JAK2
primary metabolic process (GO:0044238)	0.69	2	CALR, JAK2
regulation of cellular component movement (GO:0051270)	3.08	2	CALR, JAK2
positive regulation of locomotion (GO:0040017)	3.71	2	CALR, JAK2
cellular macromolecule localization (GO:0070727)	3.1	2	CALR, JAK2
regulation of multicellular organismal development (GO:2000026)	2.31	2	CALR, THPO
protein transport (GO:0015031)	2.62	2	CALR, JAK2
regulation of protein phosphorylation (GO:0001932)	2.57	2	THPO, JAK2
positive regulation of protein phosphorylation (GO:0001934)	2.95	2	THPO, JAK2
negative regulation of cellular process (GO:0048523)	1.41	2	CALR, JAK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
hemostasis (GO:0007599)	-	4.5	0.001	THPO, CALR, SH2B3, MPL, JAK2
homeostasis of number of cells (GO:0048872)	NEW	4.98	0.031	THPO, JAK2, MPL
regulation of body fluid levels (GO:0050878)	-	3.76	0.003	THPO, CALR, SH2B3, JAK2, MPL
blood coagulation (GO:0007596)	-	4.52	0.003	THPO, CALR, SH2B3, JAK2, MPL
thrombopoietin-mediated signaling pathway (GO:0038163)	-	8.63	0.0	THPO, MPL
coagulation (GO:0050817)	-	4.51	0.001	THPO, CALR, SH2B3, MPL, JAK2
corticosteroid receptor signaling pathway (GO:0031958)	-	7.43	0.002	CALR, JAK2
regulation of biological quality (GO:0065008)	-	1.68	0.033	THPO, CALR, SH2B3, JAK2, MPL
platelet activation (GO:0030168)	NEW	4.96	0.005	THPO, CALR, JAK2, MPL

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular part (GO:0044424)	0.28	4	CALR, SH2B3, JAK2, MPL
cytoplasmic part (GO:0044444)	0.82	4	CALR, SH2B3, JAK2, MPL
cell part (GO:0044464)	0.11	4	CALR, SH2B3, JAK2, MPL
intracellular membrane-bounded organelle (GO:0043231)	0.6	3	CALR, JAK2, MPL
plasma membrane part (GO:0044459)	1.95	3	CALR, JAK2, MPL
cytosol (GO:0005829)	1.68	3	CALR, SH2B3, JAK2
membrane (GO:0016020)	0.68	3	CALR, MPL, JAK2
intracellular organelle (GO:0043229)	0.51	3	CALR, JAK2, MPL
membrane part (GO:0044425)	0.95	3	CALR, MPL, JAK2
membrane-bounded organelle (GO:0043227)	0.47	3	CALR, JAK2, MPL
organelle (GO:0043226)	0.4	3	CALR, JAK2, MPL
cytoplasm (GO:0005737)	1.01	2	CALR, JAK2
Golgi apparatus (GO:0005794)	2.7	2	CALR, MPL
extracellular space (GO:0005615)	2.63	2	CALR, THPO
organelle lumen (GO:0043233)	3.05	2	CALR, JAK2
integral component of membrane (GO:0016021)	1.14	2	CALR, MPL
membrane-enclosed lumen (GO:0031974)	3.05	2	CALR, JAK2
intracellular (GO:0005622)	2.37	2	CALR, SH2B3
intracellular organelle part (GO:0044446)	0.81	2	CALR, JAK2
intracellular organelle lumen (GO:0070013)	3.05	2	CALR, JAK2
extracellular region (GO:0005576)	2.18	2	CALR, THPO
intrinsic component of membrane (GO:0031224)	1.13	2	CALR, MPL
nucleus (GO:0005634)	1.07	2	CALR, JAK2
cell surface (GO:0009986)	3.44	2	CALR, MPL
extracellular region part (GO:0044421)	1.57	2	CALR, THPO
organelle part (GO:0044422)	0.79	2	CALR, JAK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
endosome lumen (GO:0031904)	NEW	6.54	0.001	CALR, JAK2