Gene table of NKX2-1 : NK2 homeobox 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with NKX2-1OMIM linkNumber of associated genesgenes
118700CHOREA, BENIGN HEREDITARYClinVar, OMIM, HUMSAVAR link to OMIM 1NKX2-1
610978CHOREOATHETOSIS AND CONGENITAL HYPOTHYROIDISM WITH OR WITHOUT PULMONARY DYSFUNCTIONClinVar, OMIM, HUMSAVAR link to OMIM 1NKX2-1
PS188550THYROID CANCER, NONMEDULLARYOMIM, HUMSAVAR link to OMIM 4NKX2-1, BRAF, FOXE1, HABP2

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Annotation of the gene NKX2-1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways
Associated REACTOME pathways
Associated GO terms for Molecular function
GO termGO IDGO IC
RNA polymerase II regulatory region DNA bindingGO:00010123.36
enzyme bindingGO:00198992.27
nucleic acid binding transcription factor activityGO:00010712.65
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
heterocyclic compound bindingGO:19013631.06
sequence-specific DNA bindingGO:00435652.79
sequence-specific double-stranded DNA bindingGO:19908373.2
double-stranded DNA bindingGO:00036903.09
RNA polymerase II transcription factor activity, sequence-specific DNA bindingGO:00009813.29
regulatory region nucleic acid bindingGO:00010673.03
intronic transcription regulatory region sequence-specific DNA bindingGO:00011617.34
core promoter bindingGO:00010474.71
intronic transcription regulatory region DNA bindingGO:00442137.25
transcription regulatory region DNA bindingGO:00442123.03
transcription factor activity, sequence-specific DNA bindingGO:00037002.65
organic cyclic compound bindingGO:00971591.05
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingGO:00037055.23
transcription regulatory region sequence-specific DNA bindingGO:00009763.24
RNA polymerase II regulatory region sequence-specific DNA bindingGO:00009773.37
protein bindingGO:00055150.46
regulatory region DNA bindingGO:00009753.03
bindingGO:00054880.18