Disease table of THYROID CANCER, NONMEDULLARY OMIM ID: PS188550

Gene-disease associations table

GeneAssociated with THYROID CANCER, NONMEDULLARY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
NKX2-1OMIM, HUMSAVARHGNC link14q13.33118700, PS188550, 610978
FOXE1ClinVar, OMIMHGNC link9q22.332PS188550, 241850
BRAFClinVarHGNC link7q348605027, PS115150, PS151100, PS155600, 211980, PS188550, PS163950, 114500
HABP2OMIM, HUMSAVARHGNC link10q25.32PS188550, PS188050

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
NKX2-1YES3SFTPB, SFTPA1, LMO30
FOXE1YES2TPO, MSX10
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
NKX2-1YES6SP1, FOXP2, POU3F2, FOXA2, SP3, FOXA10
FOXE1YES1GLI20
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Thyroid cancer (hsa05216) NEW7.480.002BRAF, NKX2-1
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184BRAF, HABP2, FOXE1, NKX2-1
organic cyclic compound binding (GO:0097159) 1.053BRAF, FOXE1, NKX2-1
heterocyclic compound binding (GO:1901363) 1.063BRAF, FOXE1, NKX2-1
cation binding (GO:0043169) 1.42BRAF, HABP2
protein binding (GO:0005515) 0.462BRAF, NKX2-1
sequence-specific DNA binding (GO:0043565) 2.792FOXE1, NKX2-1
transcription factor activity, sequence-specific DNA binding (GO:0003700) 2.652FOXE1, NKX2-1
catalytic activity (GO:0003824) 1.052BRAF, HABP2
enzyme binding (GO:0019899) 2.272BRAF, NKX2-1
ion binding (GO:0043167) 1.362BRAF, HABP2
carbohydrate derivative binding (GO:0097367) 2.032BRAF, HABP2
calcium ion binding (GO:0005509) 3.172BRAF, HABP2
nucleic acid binding (GO:0003676) 1.442FOXE1, NKX2-1
DNA binding (GO:0003677) 1.922FOXE1, NKX2-1
metal ion binding (GO:0046872) 1.412BRAF, HABP2
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981) 3.292FOXE1, NKX2-1
nucleic acid binding transcription factor activity (GO:0001071) 2.652FOXE1, NKX2-1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
organic substance metabolic process (GO:0071704) 0.634BRAF, HABP2, FOXE1, NKX2-1
macromolecule metabolic process (GO:0043170) 0.834BRAF, HABP2, FOXE1, NKX2-1
metabolic process (GO:0008152) 0.584BRAF, HABP2, FOXE1, NKX2-1
primary metabolic process (GO:0044238) 0.694BRAF, HABP2, FOXE1, NKX2-1
positive regulation of metabolic process (GO:0009893) 1.743BRAF, FOXE1, NKX2-1
regulation of metabolic process (GO:0019222) 1.023BRAF, FOXE1, NKX2-1
positive regulation of cellular metabolic process (GO:0031325) 1.813BRAF, FOXE1, NKX2-1
regulation of cellular metabolic process (GO:0031323) 1.073BRAF, FOXE1, NKX2-1
positive regulation of gene expression (GO:0010628) 2.353BRAF, FOXE1, NKX2-1
anatomical structure morphogenesis (GO:0009653) 2.533BRAF, FOXE1, NKX2-1
regulation of biological process (GO:0050789) 0.453BRAF, FOXE1, NKX2-1
single-organism process (GO:0044699) 0.483BRAF, FOXE1, NKX2-1
regulation of primary metabolic process (GO:0080090) 1.083BRAF, FOXE1, NKX2-1
positive regulation of macromolecule metabolic process (GO:0010604) 1.813BRAF, FOXE1, NKX2-1
cellular macromolecule metabolic process (GO:0044260) 0.933BRAF, FOXE1, NKX2-1
animal organ development (GO:0048513) 2.533BRAF, FOXE1, NKX2-1
biological regulation (GO:0065007) 0.393BRAF, FOXE1, NKX2-1
positive regulation of biological process (GO:0048518) 1.23BRAF, FOXE1, NKX2-1
negative regulation of biological process (GO:0048519) 1.333BRAF, FOXE1, NKX2-1
regulation of biological quality (GO:0065008) 1.683BRAF, FOXE1, NKX2-1
thyroid gland development (GO:0030878) 6.473BRAF, FOXE1, NKX2-1
regulation of gene expression (GO:0010468) 1.373BRAF, FOXE1, NKX2-1
developmental process (GO:0032502) 1.363BRAF, FOXE1, NKX2-1
organ morphogenesis (GO:0009887) 3.553BRAF, FOXE1, NKX2-1
multicellular organismal process (GO:0032501) 1.453BRAF, FOXE1, NKX2-1
regulation of macromolecule metabolic process (GO:0060255) 1.083BRAF, FOXE1, NKX2-1
cellular process (GO:0009987) 0.263BRAF, FOXE1, NKX2-1
regulation of cellular process (GO:0050794) 0.53BRAF, FOXE1, NKX2-1
single-organism developmental process (GO:0044767) 1.493BRAF, FOXE1, NKX2-1
single-organism cellular process (GO:0044763) 0.653BRAF, FOXE1, NKX2-1
single-multicellular organism process (GO:0044707) 1.783BRAF, FOXE1, NKX2-1
anatomical structure development (GO:0048856) 1.583BRAF, FOXE1, NKX2-1
cellular metabolic process (GO:0044237) 0.693BRAF, FOXE1, NKX2-1
gland development (GO:0048732) 4.153BRAF, FOXE1, NKX2-1
negative regulation of cellular process (GO:0048523) 1.413BRAF, FOXE1, NKX2-1
positive regulation of cellular process (GO:0048522) 1.33BRAF, FOXE1, NKX2-1
regulation of response to stimulus (GO:0048583) 1.542BRAF, NKX2-1
behavior (GO:0007610) 3.472BRAF, NKX2-1
organic cyclic compound biosynthetic process (GO:1901362) 1.662FOXE1, NKX2-1
organic cyclic compound metabolic process (GO:1901360) 1.262FOXE1, NKX2-1
single-organism metabolic process (GO:0044710) 1.632BRAF, NKX2-1
negative regulation of macromolecule metabolic process (GO:0010605) 2.012FOXE1, NKX2-1
regulation of signal transduction (GO:0009966) 1.842BRAF, NKX2-1
cellular developmental process (GO:0048869) 1.822BRAF, NKX2-1
heterocycle metabolic process (GO:0046483) 1.312FOXE1, NKX2-1
regulation of RNA biosynthetic process (GO:2001141) 1.552FOXE1, NKX2-1
response to organic substance (GO:0010033) 2.22BRAF, NKX2-1
system process (GO:0003008) 2.32BRAF, NKX2-1
cellular biosynthetic process (GO:0044249) 1.372FOXE1, NKX2-1
protein metabolic process (GO:0019538) 1.452BRAF, HABP2
cell motility (GO:0048870) 3.022FOXE1, NKX2-1
aromatic compound biosynthetic process (GO:0019438) 1.72FOXE1, NKX2-1
regulation of cell morphogenesis (GO:0022604) 3.42BRAF, NKX2-1
negative regulation of metabolic process (GO:0009892) 1.932FOXE1, NKX2-1
negative regulation of biosynthetic process (GO:0009890) 2.472FOXE1, NKX2-1
positive regulation of biosynthetic process (GO:0009891) 2.292FOXE1, NKX2-1
movement of cell or subcellular component (GO:0006928) 2.612FOXE1, NKX2-1
negative regulation of gene expression (GO:0010629) 2.482FOXE1, NKX2-1
nitrogen compound metabolic process (GO:0006807) 1.132FOXE1, NKX2-1
nucleic acid-templated transcription (GO:0097659) 1.912FOXE1, NKX2-1
organic substance biosynthetic process (GO:1901576) 1.342FOXE1, NKX2-1
cell migration (GO:0016477) 3.122FOXE1, NKX2-1
heterocycle biosynthetic process (GO:0018130) 1.72FOXE1, NKX2-1
regulation of developmental process (GO:0050793) 2.12BRAF, NKX2-1
regulation of biosynthetic process (GO:0009889) 1.372FOXE1, NKX2-1
regulation of multicellular organismal process (GO:0051239) 1.872BRAF, NKX2-1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722FOXE1, NKX2-1
RNA metabolic process (GO:0016070) 1.592FOXE1, NKX2-1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592FOXE1, NKX2-1
response to stimulus (GO:0050896) 1.222BRAF, NKX2-1
regulation of transcription, DNA-templated (GO:0006355) 1.562FOXE1, NKX2-1
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392FOXE1, NKX2-1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242FOXE1, NKX2-1
regulation of cell motility (GO:2000145) 3.162BRAF, NKX2-1
transcription, DNA-templated (GO:0006351) 1.912FOXE1, NKX2-1
negative regulation of cell motility (GO:2000146) 4.362BRAF, NKX2-1
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532FOXE1, NKX2-1
RNA biosynthetic process (GO:0032774) 1.842FOXE1, NKX2-1
cell differentiation (GO:0030154) 2.142BRAF, NKX2-1
regulation of cellular component organization (GO:0051128) 2.012BRAF, NKX2-1
negative regulation of signaling (GO:0023057) 2.652BRAF, NKX2-1
cellular nitrogen compound metabolic process (GO:0034641) 1.222FOXE1, NKX2-1
negative regulation of cell communication (GO:0010648) 2.662BRAF, NKX2-1
cellular macromolecule biosynthetic process (GO:0034645) 1.662FOXE1, NKX2-1
regulation of signaling (GO:0023051) 1.722BRAF, NKX2-1
regulation of cell communication (GO:0010646) 1.732BRAF, NKX2-1
response to endogenous stimulus (GO:0009719) 2.792BRAF, NKX2-1
nucleobase-containing compound metabolic process (GO:0006139) 1.352FOXE1, NKX2-1
negative regulation of transcription from RNA polymerase II promoter (GO:0000122) 3.122FOXE1, NKX2-1
regulation of anatomical structure morphogenesis (GO:0022603) 2.792BRAF, NKX2-1
regulation of cell development (GO:0060284) 3.012BRAF, NKX2-1
regulation of cell morphogenesis involved in differentiation (GO:0010769) 3.912BRAF, NKX2-1
biological adhesion (GO:0022610) 2.812BRAF, HABP2
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562FOXE1, NKX2-1
locomotion (GO:0040011) 2.912FOXE1, NKX2-1
cellular aromatic compound metabolic process (GO:0006725) 1.32FOXE1, NKX2-1
negative regulation of cellular component movement (GO:0051271) 4.222BRAF, NKX2-1
regulation of nucleic acid-templated transcription (GO:1903506) 1.552FOXE1, NKX2-1
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712FOXE1, NKX2-1
regulation of cell differentiation (GO:0045595) 2.422BRAF, NKX2-1
regulation of locomotion (GO:0040012) 3.122BRAF, NKX2-1
negative regulation of transcription, DNA-templated (GO:0045892) 2.752FOXE1, NKX2-1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562FOXE1, NKX2-1
regulation of localization (GO:0032879) 1.942BRAF, NKX2-1
response to hormone (GO:0009725) 3.332BRAF, NKX2-1
negative regulation of RNA metabolic process (GO:0051253) 2.662FOXE1, NKX2-1
regulation of RNA metabolic process (GO:0051252) 1.522FOXE1, NKX2-1
positive regulation of RNA metabolic process (GO:0051254) 2.512FOXE1, NKX2-1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542FOXE1, NKX2-1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32FOXE1, NKX2-1
negative regulation of cellular biosynthetic process (GO:0031327) 2.492FOXE1, NKX2-1
regulation of cellular biosynthetic process (GO:0031326) 1.382FOXE1, NKX2-1
negative regulation of cellular metabolic process (GO:0031324) 2.012FOXE1, NKX2-1
nucleic acid metabolic process (GO:0090304) 1.462FOXE1, NKX2-1
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462FOXE1, NKX2-1
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62FOXE1, NKX2-1
regulation of macromolecule biosynthetic process (GO:0010556) 1.432FOXE1, NKX2-1
thymus development (GO:0048538) 5.882BRAF, FOXE1
hematopoietic or lymphoid organ development (GO:0048534) 4.492BRAF, FOXE1
negative regulation of cell migration (GO:0030336) 4.412BRAF, NKX2-1
regulation of cell migration (GO:0030334) 3.232BRAF, NKX2-1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352FOXE1, NKX2-1
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552FOXE1, NKX2-1
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432FOXE1, NKX2-1
negative regulation of RNA biosynthetic process (GO:1902679) 2.72FOXE1, NKX2-1
biosynthetic process (GO:0009058) 1.322FOXE1, NKX2-1
macromolecule biosynthetic process (GO:0009059) 1.612FOXE1, NKX2-1
regulation of nitrogen compound metabolic process (GO:0051171) 1.362FOXE1, NKX2-1
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472FOXE1, NKX2-1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292FOXE1, NKX2-1
cell adhesion (GO:0007155) 2.822BRAF, HABP2
response to chemical (GO:0042221) 1.982BRAF, NKX2-1
response to oxygen-containing compound (GO:1901700) 2.572BRAF, NKX2-1
response to abiotic stimulus (GO:0009628) 2.82BRAF, NKX2-1
negative regulation of locomotion (GO:0040013) 4.222BRAF, NKX2-1
regulation of cellular component movement (GO:0051270) 3.082BRAF, NKX2-1
phosphate-containing compound metabolic process (GO:0006796) 2.162BRAF, NKX2-1
regulation of multicellular organismal development (GO:2000026) 2.312BRAF, NKX2-1
phosphorus metabolic process (GO:0006793) 2.152BRAF, NKX2-1

NET-GE enrichment

Term New enriched termICP valueGenes
phenol-containing compound metabolic process (GO:0018958) NEW5.330.01BRAF, FOXE1, NKX2-1
hard palate development (GO:0060022) NEW7.940.003FOXE1, NKX2-1
thyroid gland development (GO:0030878) -6.470.002FOXE1, NKX2-1
thyroid hormone generation (GO:0006590) NEW7.160.021FOXE1, NKX2-1
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.63BRAF, FOXE1, NKX2-1
nucleus (GO:0005634) 1.073BRAF, FOXE1, NKX2-1
cell part (GO:0044464) 0.113BRAF, FOXE1, NKX2-1
intracellular organelle (GO:0043229) 0.513BRAF, FOXE1, NKX2-1
intracellular part (GO:0044424) 0.283BRAF, FOXE1, NKX2-1
membrane-bounded organelle (GO:0043227) 0.473BRAF, FOXE1, NKX2-1
organelle (GO:0043226) 0.43BRAF, FOXE1, NKX2-1