Gene table of SLC6A4 : solute carrier family 6 member 4

Gene-disease associations table

Disease ID	Disease name	Source of annotation with SLC6A4	OMIM link	Number of associated genes	genes
164230	OBSESSIVE-COMPULSIVE DISORDER	OMIM	link to OMIM	3	BDNF, SLC6A4, HTR2A
607834	ANXIETY	OMIM	link to OMIM	1	SLC6A4

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Annotation of the gene SLC6A4

Associated genes in ENSEMBL

ENSG00000108576

Associated proteins - SwissProt Accession ID

P31645

Associated PDB IDs

Cytogenetic Band

17q11.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Serotonergic synapse	hsa04726	5.84

Associated REACTOME pathways

Associated GO terms for Molecular function

GO term	GO ID	GO IC
neurotransmitter:sodium symporter activity	GO:0005328	6.79
neurotransmitter transporter activity	GO:0005326	6.52
enzyme binding	GO:0019899	2.27
drug binding	GO:0008144	5.03
small GTPase binding	GO:0031267	4.13
GTPase binding	GO:0051020	4.05
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
heterocyclic compound binding	GO:1901363	1.06
cocaine binding	GO:0019811	9.74
cation binding	GO:0043169	1.4
serotonin:sodium symporter activity	GO:0005335	9.74
monoamine transmembrane transporter activity	GO:0008504	7.54
SNARE binding	GO:0000149	4.87
organic hydroxy compound transmembrane transporter activity	GO:1901618	6.02
ion binding	GO:0043167	1.36
actin binding	GO:0003779	3.74
transmembrane transporter activity	GO:0022857	2.82
solute:sodium symporter activity	GO:0015370	5.83
protein complex binding	GO:0032403	3.09
metal ion transmembrane transporter activity	GO:0046873	3.71
metal ion binding	GO:0046872	1.41
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
solute:cation symporter activity	GO:0015294	5.15
secondary active transmembrane transporter activity	GO:0015291	4.29
symporter activity	GO:0015293	4.78
inorganic cation transmembrane transporter activity	GO:0022890	3.49
transporter activity	GO:0005215	2.57
cation transmembrane transporter activity	GO:0008324	3.32
Rab GTPase binding	GO:0017137	4.96
actin filament binding	GO:0051015	4.93
Ras GTPase binding	GO:0017016	4.2
syntaxin binding	GO:0019905	5.19
myosin binding	GO:0017022	5.66
syntaxin-1 binding	GO:0017075	6.85
sodium ion transmembrane transporter activity	GO:0015081	4.83
substrate-specific transmembrane transporter activity	GO:0022891	2.9
nitric-oxide synthase binding	GO:0050998	6.91
serotonin transmembrane transporter activity	GO:0015222	8.64
substrate-specific transporter activity	GO:0022892	2.72
cytoskeletal protein binding	GO:0008092	3.02
organic cyclic compound binding	GO:0097159	1.05
ion transmembrane transporter activity	GO:0015075	3.04
monovalent inorganic cation transmembrane transporter activity	GO:0015077	3.87
active transmembrane transporter activity	GO:0022804	3.85
protein binding	GO:0005515	0.46
protein dimerization activity	GO:0046983	2.72