Disease table of OBSESSIVE-COMPULSIVE DISORDER OMIM ID: 164230

Gene-disease associations table

GeneAssociated with OBSESSIVE-COMPULSIVE DISORDER inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
BDNFOMIMHGNC link11p14.14607499, 164230, 209880, 610269
HTR2AOMIMHGNC link13q14.25103780, 181500, 608516, 164230, 606788
SLC6A4OMIMHGNC link17q11.22164230, 607834

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
BDNFYES2REST, CREB10
SLC6A4YES2CTCF, YBX10
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
BDNFHTR2ANo-1FOS
BDNFSLC6A4No-2SNCA, AKT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Serotonergic synapsehsa047265.842SLC6A4, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
Mineral absorption (hsa04978) NEW7.090.018SLC6A4, BDNF
Nervous systemNEW3.770.009SLC6A4, HTR2A, BDNF
Cocaine addiction (hsa05030) NEW7.070.02HTR2A, BDNF
GABAergic synapse (hsa04727) NEW6.240.0SLC6A4, HTR2A, BDNF
Serotonergic synapse (hsa04726) -5.840.021SLC6A4, HTR2A
REACTOME pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Neuronal System (R-HSA-112316) NEW4.820.02SLC6A4, HTR2A, BDNF
Transmission across Chemical Synapses (R-HSA-112315) NEW5.280.008SLC6A4, HTR2A, BDNF
Neurotransmitter Release Cycle (R-HSA-112310) NEW7.340.033SLC6A4, BDNF
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.183SLC6A4, HTR2A, BDNF
protein binding (GO:0005515) 0.463SLC6A4, HTR2A, BDNF
protein complex binding (GO:0032403) 3.092SLC6A4, HTR2A
organic cyclic compound binding (GO:0097159) 1.052SLC6A4, HTR2A
macromolecular complex binding (GO:0044877) 2.612SLC6A4, HTR2A
heterocyclic compound binding (GO:1901363) 1.062SLC6A4, HTR2A
drug binding (GO:0008144) 5.032SLC6A4, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
drug binding (GO:0008144) -5.030.001SLC6A4, HTR2A, BDNF
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
developmental process (GO:0032502) 1.363SLC6A4, HTR2A, BDNF
single organism signaling (GO:0044700) 3.253SLC6A4, HTR2A, BDNF
cell communication (GO:0007154) 3.043SLC6A4, HTR2A, BDNF
cellular process (GO:0009987) 0.263SLC6A4, HTR2A, BDNF
signaling (GO:0023052) 3.253SLC6A4, HTR2A, BDNF
regulation of cellular process (GO:0050794) 0.53SLC6A4, HTR2A, BDNF
single-organism developmental process (GO:0044767) 1.493SLC6A4, HTR2A, BDNF
positive regulation of biological process (GO:0048518) 1.23SLC6A4, HTR2A, BDNF
regulation of cell differentiation (GO:0045595) 2.423SLC6A4, HTR2A, BDNF
biological regulation (GO:0065007) 0.393SLC6A4, HTR2A, BDNF
single-organism cellular process (GO:0044763) 0.653SLC6A4, HTR2A, BDNF
single-organism process (GO:0044699) 0.483SLC6A4, HTR2A, BDNF
regulation of multicellular organismal process (GO:0051239) 1.873SLC6A4, HTR2A, BDNF
regulation of signaling (GO:0023051) 1.723SLC6A4, HTR2A, BDNF
cell-cell signaling (GO:0007267) 3.353SLC6A4, HTR2A, BDNF
negative regulation of biological process (GO:0048519) 1.333SLC6A4, HTR2A, BDNF
regulation of cell communication (GO:0010646) 1.733SLC6A4, HTR2A, BDNF
regulation of biological process (GO:0050789) 0.453SLC6A4, HTR2A, BDNF
negative regulation of cellular process (GO:0048523) 1.413SLC6A4, HTR2A, BDNF
positive regulation of cellular process (GO:0048522) 1.33SLC6A4, HTR2A, BDNF
modulation of synaptic transmission (GO:0050804) 4.092SLC6A4, HTR2A
regulation of developmental growth (GO:0048638) 4.042SLC6A4, BDNF
cellular component assembly (GO:0022607) 2.142SLC6A4, BDNF
positive regulation of metabolic process (GO:0009893) 1.742SLC6A4, HTR2A
regulation of metabolic process (GO:0019222) 1.022SLC6A4, HTR2A
response to drug (GO:0042493) 3.712SLC6A4, HTR2A
positive regulation of response to stimulus (GO:0048584) 2.182HTR2A, BDNF
regulation of response to stimulus (GO:0048583) 1.542HTR2A, BDNF
memory (GO:0007613) 5.132SLC6A4, HTR2A
behavior (GO:0007610) 3.472SLC6A4, HTR2A
learning or memory (GO:0007611) 4.332SLC6A4, HTR2A
positive regulation of signaling (GO:0023056) 2.412HTR2A, BDNF
vascular process in circulatory system (GO:0003018) 4.652SLC6A4, HTR2A
circulatory system process (GO:0003013) 4.382SLC6A4, HTR2A
signal transduction (GO:0007165) 1.282HTR2A, BDNF
vasoconstriction (GO:0042310) 6.362SLC6A4, HTR2A
positive regulation of cell communication (GO:0010647) 2.412HTR2A, BDNF
cellular component organization or biogenesis (GO:0071840) 1.222SLC6A4, BDNF
cellular component organization (GO:0016043) 1.242SLC6A4, BDNF
negative regulation of cell communication (GO:0010648) 2.662SLC6A4, HTR2A
regulation of neurogenesis (GO:0050767) 3.212SLC6A4, BDNF
regulation of blood vessel size (GO:0050880) 4.82SLC6A4, HTR2A
positive regulation of macromolecule metabolic process (GO:0010604) 1.812SLC6A4, HTR2A
regulation of signal transduction (GO:0009966) 1.842HTR2A, BDNF
positive regulation of signal transduction (GO:0009967) 2.52HTR2A, BDNF
positive regulation of multicellular organismal process (GO:0051240) 2.492HTR2A, BDNF
regulation of tube size (GO:0035150) 4.792SLC6A4, HTR2A
regulation of cell development (GO:0060284) 3.012SLC6A4, BDNF
regulation of anatomical structure size (GO:0090066) 3.782SLC6A4, HTR2A
regulation of neuron differentiation (GO:0045664) 3.392SLC6A4, BDNF
anterograde trans-synaptic signaling (GO:0098916) 3.982SLC6A4, HTR2A
transmembrane transport (GO:0055085) 2.722SLC6A4, HTR2A
system process (GO:0003008) 2.32SLC6A4, HTR2A
regulation of cell proliferation (GO:0042127) 2.412SLC6A4, HTR2A
multicellular organismal process (GO:0032501) 1.452SLC6A4, HTR2A
regulation of developmental process (GO:0050793) 2.12SLC6A4, BDNF
neurological system process (GO:0050877) 2.642SLC6A4, HTR2A
transport (GO:0006810) 1.512SLC6A4, HTR2A
positive regulation of cell differentiation (GO:0045597) 3.012HTR2A, BDNF
single-organism transport (GO:0044765) 2.182SLC6A4, HTR2A
negative regulation of synaptic transmission (GO:0050805) 5.672SLC6A4, HTR2A
chemical synaptic transmission (GO:0007268) 3.982SLC6A4, HTR2A
establishment of localization in cell (GO:0051649) 2.472SLC6A4, HTR2A
response to chemical (GO:0042221) 1.982SLC6A4, HTR2A
establishment of localization (GO:0051234) 1.482SLC6A4, HTR2A
localization (GO:0051179) 1.42SLC6A4, HTR2A
single-organism localization (GO:1902578) 2.092SLC6A4, HTR2A
multi-organism process (GO:0051704) 2.652SLC6A4, HTR2A
response to abiotic stimulus (GO:0009628) 2.82SLC6A4, HTR2A
regulation of biological quality (GO:0065008) 1.682SLC6A4, HTR2A
single-multicellular organism process (GO:0044707) 1.782SLC6A4, HTR2A
response to external stimulus (GO:0009605) 2.552SLC6A4, HTR2A
negative regulation of signaling (GO:0023057) 2.652SLC6A4, HTR2A
regulation of macromolecule metabolic process (GO:0060255) 1.082SLC6A4, HTR2A
single-organism behavior (GO:0044708) 3.792SLC6A4, HTR2A
response to stimulus (GO:0050896) 1.222SLC6A4, HTR2A
anatomical structure development (GO:0048856) 1.582SLC6A4, BDNF
cognition (GO:0050890) 4.22SLC6A4, HTR2A
regulation of nervous system development (GO:0051960) 3.12SLC6A4, BDNF
regulation of multicellular organismal development (GO:2000026) 2.312SLC6A4, BDNF
regulation of growth (GO:0040008) 3.262SLC6A4, BDNF
synaptic signaling (GO:0099536) 3.982SLC6A4, HTR2A
trans-synaptic signaling (GO:0099537) 3.982SLC6A4, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
cognition (GO:0050890) -4.20.001SLC6A4, HTR2A, BDNF
memory (GO:0007613) -5.130.031SLC6A4, HTR2A, BDNF
negative regulation of synaptic transmission (GO:0050805) -5.670.0SLC6A4, HTR2A, BDNF
regulation of synaptic transmission (GO:0050804) -4.090.001SLC6A4, HTR2A, BDNF
vasoconstriction (GO:0042310) -6.360.039SLC6A4, HTR2A
positive regulation of positive chemotaxis (GO:0050927) NEW6.590.049HTR2A, BDNF
vascular process in circulatory system (GO:0003018) -4.650.028SLC6A4, HTR2A
regulation of neural precursor cell proliferation (GO:2000177) NEW5.450.016SLC6A4, BDNF
response to organic cyclic compound (GO:0014070) NEW3.070.026SLC6A4, HTR2A, BDNF
regulation of blood vessel size (GO:0050880) -4.80.015SLC6A4, HTR2A
negative regulation of glial cell differentiation (GO:0045686) NEW6.430.042HTR2A, BDNF
positive regulation of dendritic spine development (GO:0060999) NEW6.170.02HTR2A, BDNF
negative regulation of neural precursor cell proliferation (GO:2000178) NEW6.640.022SLC6A4, BDNF
regulation of tube size (GO:0035150) -4.790.016SLC6A4, HTR2A
response to retinoic acid (GO:0032526) NEW5.020.013SLC6A4, HTR2A, BDNF
circadian rhythm (GO:0007623) NEW4.790.01SLC6A4, HTR2A, BDNF
neurological system process (GO:0050877) -2.640.029SLC6A4, HTR2A, BDNF
behavior (GO:0007610) -3.470.009SLC6A4, HTR2A, BDNF
cellular response to acid chemical (GO:0071229) NEW4.670.023SLC6A4, HTR2A, BDNF
learning or memory (GO:0007611) -4.330.001SLC6A4, HTR2A, BDNF
single-organism behavior (GO:0044708) -3.790.003SLC6A4, HTR2A, BDNF
response to drug (GO:0042493) -3.710.003SLC6A4, HTR2A, BDNF
positive regulation of nervous system development (GO:0051962) NEW3.640.036HTR2A, BDNF
positive regulation of synapse assembly (GO:0051965) NEW5.620.036HTR2A, BDNF
positive regulation of synaptic transmission, glutamatergic (GO:0051968) NEW6.840.015HTR2A, BDNF
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular membrane-bounded organelle (GO:0043231) 0.63SLC6A4, HTR2A, BDNF
integral component of membrane (GO:0016021) 1.143SLC6A4, HTR2A, BDNF
membrane (GO:0016020) 0.683SLC6A4, HTR2A, BDNF
cell part (GO:0044464) 0.113SLC6A4, HTR2A, BDNF
cytoplasmic part (GO:0044444) 0.823SLC6A4, HTR2A, BDNF
intracellular organelle (GO:0043229) 0.513SLC6A4, HTR2A, BDNF
intracellular part (GO:0044424) 0.283SLC6A4, HTR2A, BDNF
membrane part (GO:0044425) 0.953SLC6A4, HTR2A, BDNF
membrane-bounded organelle (GO:0043227) 0.473SLC6A4, HTR2A, BDNF
organelle (GO:0043226) 0.43SLC6A4, HTR2A, BDNF
intrinsic component of membrane (GO:0031224) 1.133SLC6A4, HTR2A, BDNF
cytoplasm (GO:0005737) 1.012HTR2A, BDNF
membrane raft (GO:0045121) 4.182SLC6A4, HTR2A
vesicle (GO:0031982) 1.642HTR2A, BDNF
plasma membrane part (GO:0044459) 1.952SLC6A4, HTR2A
cytoplasmic, membrane-bounded vesicle (GO:0016023) 3.122HTR2A, BDNF
cytoplasmic vesicle (GO:0031410) 2.872HTR2A, BDNF
cytosol (GO:0005829) 1.682SLC6A4, HTR2A
membrane region (GO:0098589) 3.952SLC6A4, HTR2A
membrane-bounded vesicle (GO:0031988) 1.712HTR2A, BDNF
neuron part (GO:0097458) 2.642SLC6A4, HTR2A
membrane microdomain (GO:0098857) 4.172SLC6A4, HTR2A
intracellular vesicle (GO:0097708) 2.862HTR2A, BDNF
neuron projection (GO:0043005) 3.122SLC6A4, HTR2A
plasma membrane (GO:0005886) 1.392SLC6A4, HTR2A
integral component of plasma membrane (GO:0005887) 2.572SLC6A4, HTR2A
cell projection (GO:0042995) 2.472SLC6A4, HTR2A
intrinsic component of plasma membrane (GO:0031226) 2.532SLC6A4, HTR2A

NET-GE enrichment

Term New enriched termICP valueGenes
membrane raft (GO:0045121) -4.180.015SLC6A4, HTR2A
axon (GO:0030424) NEW4.150.003SLC6A4, HTR2A, BDNF