Gene table of STAT5B : signal transducer and activator of transcription 5B

Gene-disease associations table

Disease ID	Disease name	Source of annotation with STAT5B	OMIM link	Number of associated genes	genes
245590	GROWTH HORMONE INSENSITIVITY WITH IMMUNODEFICIENCY	OMIM, HUMSAVAR	link to OMIM	1	STAT5B

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Annotation of the gene STAT5B

Associated genes in ENSEMBL

ENSG00000173757

Associated proteins - SwissProt Accession ID

P51692

Associated PDB IDs

Cytogenetic Band

17q21.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Pathways in cancer	hsa05200	3.98
Viral carcinogenesis	hsa05203	5.08
Jak-STAT signaling pathway	hsa04630	5.44
ErbB signaling pathway	hsa04012	6.15
Acute myeloid leukemia	hsa05221	6.74
Chronic myeloid leukemia	hsa05220	6.48
HTLV-I infection	hsa05166	4.59
Chemokine signaling pathway	hsa04062	5.19
Hepatitis B	hsa05161	5.52
Measles	hsa05162	5.6
Prolactin signaling pathway	hsa04917	6.6

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by ERBB4	R-HSA-1236394	4.7
Signal Transduction	R-HSA-162582	1.78
Disease	R-HSA-1643685	3.33
Signaling by Interleukins	R-HSA-449147	4.71
Growth hormone receptor signaling	R-HSA-982772	8.4
Signaling by Leptin	R-HSA-2586552	5.1
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99
Interleukin-2 signaling	R-HSA-451927	5.05
Prolactin receptor signaling	R-HSA-1170546	9.08
Signaling by FGFR in disease	R-HSA-1226099	7.49
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Downstream signal transduction	R-HSA-186763	4.65
Diseases of signal transduction	R-HSA-5663202	4.89
Signaling by FGFR1 fusion mutants	R-HSA-1839117	8.81
Signaling by PDGF	R-HSA-186797	4.53
Interleukin-7 signaling	R-HSA-1266695	9.52
Signaling by SCF-KIT	R-HSA-1433557	4.73
Signaling by FGFR1 in disease	R-HSA-5655302	7.81
FGFR1 mutant receptor activation	R-HSA-1839124	8.12
Nuclear signaling by ERBB4	R-HSA-1251985	7.7
Immune System	R-HSA-168256	2.37

Associated GO terms for Molecular function

GO term	GO ID	GO IC
nucleic acid binding	GO:0003676	1.44
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
enzyme binding	GO:0019899	2.27
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0001077	4.31
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
DNA binding	GO:0003677	1.92
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
transferase activity	GO:0016740	1.95
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
double-stranded DNA binding	GO:0003690	3.09
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0000982	3.94
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
glucocorticoid receptor binding	GO:0035259	6.97
steroid hormone receptor binding	GO:0035258	5.32
regulatory region nucleic acid binding	GO:0001067	3.03
kinase activity	GO:0016301	2.93
nuclear hormone receptor binding	GO:0035257	4.7
catalytic activity	GO:0003824	1.05
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
core promoter binding	GO:0001047	4.71
core promoter sequence-specific DNA binding	GO:0001046	5.12
hormone receptor binding	GO:0051427	4.57
receptor binding	GO:0005102	2.43
transcription regulatory region DNA binding	GO:0044212	3.03
RNA polymerase II core promoter sequence-specific DNA binding	GO:0000979	5.77
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
protein dimerization activity	GO:0046983	2.72
chromatin binding	GO:0003682	3.64
nucleic acid binding transcription factor activity	GO:0001071	2.65