| Disease ID | Disease name | Source of annotation with TNFRSF1A | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS126200 | MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO | ClinVar, OMIM | link to OMIM | 4 | HLA-DRB1, PDCD1, HLA-DQB1, TNFRSF1A |
| 142680 | PERIODIC FEVER, FAMILIAL, AUTOSOMAL DOMINANT | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | TNFRSF1A |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Hepatitis C | hsa05160 | 5.68 |
| MAPK signaling pathway | hsa04010 | 4.63 |
| Toxoplasmosis | hsa05145 | 5.71 |
| Amyotrophic lateral sclerosis (ALS) | hsa05014 | 7.01 |
| Tuberculosis | hsa05152 | 5.17 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| TNF signaling pathway | hsa04668 | 5.96 |
| Herpes simplex infection | hsa05168 | 5.08 |
| Non-alcoholic fatty liver disease (NAFLD) | hsa04932 | 5.51 |
| Osteoclast differentiation | hsa04380 | 5.64 |
| Influenza A | hsa05164 | 5.21 |
| Apoptosis | hsa04210 | 6.23 |
| HTLV-I infection | hsa05166 | 4.59 |
| Alzheimer's disease | hsa05010 | 5.34 |
| NF-kappa B signaling pathway | hsa04064 | 6.21 |
| Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
| Adipocytokine signaling pathway | hsa04920 | 6.6 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TNFR2 non-canonical NF-kB pathway | R-HSA-5668541 | 6.4 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 9.28 |
| Immune System | R-HSA-168256 | 2.37 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| Death Receptor Signalling | R-HSA-73887 | 8.52 |
| TNF signaling | R-HSA-75893 | 9.08 |
| TNFs bind their physiological receptors | R-HSA-5669034 | 8.34 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| binding | GO:0005488 | 0.18 |
| signaling receptor activity | GO:0038023 | 2.49 |
| protein binding | GO:0005515 | 0.46 |
| molecular transducer activity | GO:0060089 | 2.32 |
| cytokine binding | GO:0019955 | 5.21 |
| death receptor activity | GO:0005035 | 6.56 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| tumor necrosis factor-activated receptor activity | GO:0005031 | 6.56 |
| signal transducer activity | GO:0004871 | 2.28 |
| tumor necrosis factor binding | GO:0043120 | 9.05 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| receptor activity | GO:0004872 | 2.32 |