Disease table of MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO OMIM ID: PS126200

Gene-disease associations table

GeneAssociated with MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
HLA-DRB1OMIMHGNC link6p21.323PS126200, 180300, 181000
HLA-DQB1OMIMHGNC link6p21.323123400, PS212750, PS126200
TNFRSF1AClinVar, OMIMHGNC link12p13.312PS126200, 142680
PDCD1OMIMHGNC link2q37.32PS126200, 605218

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 2922HLA-DRB1, HLA-DQB1
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
6p21.322HLA-DRB1, HLA-DQB1
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
6p212HLA-DRB1, HLA-DQB1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
6p22HLA-DRB1, HLA-DQB1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
6p2HLA-DRB1, HLA-DQB1
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
62HLA-DRB1, HLA-DQB1
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
RFXANKNO15HLA-DQA2, HLA-DQA1, HLA-DQB2, HLA-DQB1, HLA-DMA, HLA-DRB4, HLA-DOA, HLA-DPB1, HLA-DRB5, HLA-DRB1, HLA-DMB, HLA-DPA1, HLA-DRB3, HLA-DOB, HLA-DRA2HLA-DQB1, HLA-DRB1
CIITANO30IRF2, HDAC2, COL1A2, HLA-DRB4, HLA-DRB1, HLA-DRB3, HLA-DRA, IL4, HLA-DMA, HLA-C, SIRT1, HLA-DQB1, HLA-B, SLC26A3, HLA-A, PLXNA1, COL1A1, HLA-DMB, HLA-DRB5, S100A4, MMP9, IRF1, PSMC5, HLA-DOB, HLA-DOA, HLA-DPB1, HLA-G, RAB4B, CREBBP, FASLG2HLA-DQB1, HLA-DRB1
RFXAPNO15HLA-DQA2, HLA-DQA1, HLA-DQB2, HLA-DQB1, HLA-DMA, HLA-DRB4, HLA-DOA, HLA-DPB1, HLA-DRB5, HLA-DRB1, HLA-DMB, HLA-DPA1, HLA-DRB3, HLA-DOB, HLA-DRA2HLA-DQB1, HLA-DRB1
RFX5NO18HLA-DQA2, HLA-DQA1, HLA-DQB2, HLA-DQB1, HLA-DMA, COL1A2, HDAC2, HLA-DRB4, IFNG, HLA-DOA, HLA-DPB1, HLA-DRB5, HLA-DRB1, HLA-DMB, HLA-DPA1, HLA-DRB3, HLA-DOB, HLA-DRA2HLA-DQB1, HLA-DRB1
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
HLA-DRB1YES5CIITA, RFXANK, ILF3, RFXAP, RFX50
HLA-DQB1YES6RFXANK, RFX5, RFXAP, CREB1, CIITA, DEK0
PDCD1YES2STAT2, STAT10
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
HLA-DRB1TNFRSF1ANo1HSPA8

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Gene1Gene2InteractionNumber of common interactorsCommon genes in interaction
HLA-DRB1HLA-DQB1No1INS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Toxoplasmosishsa051455.713TNFRSF1A, HLA-DQB1, HLA-DRB1
Cell adhesion molecules (CAMs)hsa045145.363PDCD1, HLA-DQB1, HLA-DRB1
Herpes simplex infectionhsa051685.083TNFRSF1A, HLA-DQB1, HLA-DRB1
Tuberculosishsa051525.173TNFRSF1A, HLA-DQB1, HLA-DRB1
Influenza Ahsa051645.213TNFRSF1A, HLA-DQB1, HLA-DRB1
HTLV-I infectionhsa051664.593TNFRSF1A, HLA-DQB1, HLA-DRB1
Antigen processing and presentationhsa046126.042HLA-DQB1, HLA-DRB1
Systemic lupus erythematosushsa053225.952HLA-DQB1, HLA-DRB1
Rheumatoid arthritishsa053236.052HLA-DQB1, HLA-DRB1
Autoimmune thyroid diseasehsa053206.622HLA-DQB1, HLA-DRB1
Inflammatory bowel disease (IBD)hsa053216.432HLA-DQB1, HLA-DRB1
Allograft rejectionhsa053306.912HLA-DQB1, HLA-DRB1
Graft-versus-host diseasehsa053326.842HLA-DQB1, HLA-DRB1
Intestinal immune network for IgA productionhsa046726.792HLA-DQB1, HLA-DRB1
Leishmaniasishsa051406.322HLA-DQB1, HLA-DRB1
Phagosomehsa041455.272HLA-DQB1, HLA-DRB1
Epstein-Barr virus infectionhsa051694.972HLA-DQB1, HLA-DRB1
Asthmahsa053107.342HLA-DQB1, HLA-DRB1
Type I diabetes mellitushsa049406.792HLA-DQB1, HLA-DRB1
Viral myocarditishsa054166.452HLA-DQB1, HLA-DRB1
Staphylococcus aureus infectionhsa051506.642HLA-DQB1, HLA-DRB1

NET-GE enrichment

Term New enriched termICP valueGenes
Antigen processing and presentation (hsa04612) -6.040.003HLA-DQB1, HLA-DRB1
Allograft rejection (hsa05330) -6.910.0HLA-DQB1, HLA-DRB1
Graft-versus-host disease (hsa05332) -6.840.0HLA-DQB1, HLA-DRB1
Intestinal immune network for IgA production (hsa04672) -6.790.0TNFRSF1A, HLA-DQB1, HLA-DRB1
Cell adhesion molecules (CAMs) (hsa04514) -5.360.001PDCD1, HLA-DQB1, HLA-DRB1
Phagosome (hsa04145) -5.270.009HLA-DQB1, HLA-DRB1
Immune systemNEW2.920.048TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
Asthma (hsa05310) -7.340.0HLA-DQB1, HLA-DRB1
Type I diabetes mellitus (hsa04940) -6.790.0TNFRSF1A, HLA-DQB1, HLA-DRB1
Viral myocarditis (hsa05416) -6.450.002HLA-DQB1, HLA-DRB1
Leishmaniasis (hsa05140) -6.320.001HLA-DQB1, HLA-DRB1
Herpes simplex infection (hsa05168) -5.080.0TNFRSF1A, HLA-DQB1, HLA-DRB1
Epstein-Barr virus infection (hsa05169) -4.970.017HLA-DQB1, HLA-DRB1
Toxoplasmosis (hsa05145) -5.710.0TNFRSF1A, HLA-DQB1, HLA-DRB1
Influenza A (hsa05164) -5.210.0TNFRSF1A, HLA-DQB1, HLA-DRB1
HTLV-I infection (hsa05166) -4.590.012TNFRSF1A, HLA-DQB1, HLA-DRB1
Infectious diseases: ViralNEW3.290.027TNFRSF1A, HLA-DQB1, HLA-DRB1
Immune diseasesNEW4.470.016TNFRSF1A, HLA-DQB1, HLA-DRB1
Inflammatory bowel disease (IBD) (hsa05321) -6.430.003HLA-DQB1, HLA-DRB1
Endocrine and metabolic diseasesNEW4.750.0TNFRSF1A, HLA-DQB1, HLA-DRB1
Infectious diseases: BacterialNEW3.760.007TNFRSF1A, HLA-DQB1, HLA-DRB1
Cardiovascular diseasesNEW5.060.002TNFRSF1A, HLA-DQB1, HLA-DRB1
Systemic lupus erythematosus (hsa05322) -5.950.002TNFRSF1A, HLA-DQB1, HLA-DRB1
Rheumatoid arthritis (hsa05323) -6.050.0TNFRSF1A, HLA-DQB1, HLA-DRB1
Autoimmune thyroid disease (hsa05320) -6.620.002HLA-DQB1, HLA-DRB1
Infectious diseases: ParasiticNEW4.460.001TNFRSF1A, HLA-DQB1, HLA-DRB1
Signaling molecules and interactionNEW3.090.019TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
Staphylococcus aureus infection (hsa05150) -6.640.001HLA-DQB1, HLA-DRB1
Tuberculosis (hsa05152) -5.170.0TNFRSF1A, HLA-DQB1, HLA-DRB1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Immune SystemR-HSA-1682562.374TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
Cytokine Signaling in Immune systemR-HSA-12802153.743TNFRSF1A, HLA-DQB1, HLA-DRB1
PD-1 signalingR-HSA-3899487.623PDCD1, HLA-DQB1, HLA-DRB1
Costimulation by the CD28 familyR-HSA-3888416.563PDCD1, HLA-DQB1, HLA-DRB1
Adaptive Immune SystemR-HSA-12802183.193PDCD1, HLA-DQB1, HLA-DRB1
Generation of second messenger moleculesR-HSA-2024337.342HLA-DQB1, HLA-DRB1
Translocation of ZAP-70 to Immunological synapseR-HSA-2024307.812HLA-DQB1, HLA-DRB1
Downstream TCR signalingR-HSA-2024247.012HLA-DQB1, HLA-DRB1
Phosphorylation of CD3 and TCR zeta chainsR-HSA-2024277.732HLA-DQB1, HLA-DRB1
Interferon gamma signalingR-HSA-8773005.672HLA-DQB1, HLA-DRB1
MHC class II antigen presentationR-HSA-21322956.012HLA-DQB1, HLA-DRB1
Interferon SignalingR-HSA-9135314.952HLA-DQB1, HLA-DRB1
TCR signalingR-HSA-2024036.642HLA-DQB1, HLA-DRB1

NET-GE enrichment

Term New enriched termICP valueGenes
Generation of second messenger molecules (R-HSA-202433) -7.340.0HLA-DQB1, HLA-DRB1
PD-1 signaling (R-HSA-389948) -7.620.0PDCD1, HLA-DQB1, HLA-DRB1
Translocation of ZAP-70 to Immunological synapse (R-HSA-202430) -7.810.0HLA-DQB1, HLA-DRB1
Downstream TCR signaling (R-HSA-202424) -7.010.0TNFRSF1A, HLA-DQB1, HLA-DRB1
Phosphorylation of CD3 and TCR zeta chains (R-HSA-202427) -7.730.0HLA-DQB1, HLA-DRB1
Immune System (R-HSA-168256) -2.370.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
Adaptive Immune System (R-HSA-1280218) -3.190.0PDCD1, HLA-DQB1, HLA-DRB1
Cytokine Signaling in Immune system (R-HSA-1280215) -3.740.0TNFRSF1A, HLA-DQB1, HLA-DRB1
Interferon gamma signaling (R-HSA-877300) -5.670.0HLA-DQB1, HLA-DRB1
MHC class II antigen presentation (R-HSA-2132295) -6.010.0HLA-DQB1, HLA-DRB1
Interferon Signaling (R-HSA-913531) -4.950.0HLA-DQB1, HLA-DRB1
Costimulation by the CD28 family (R-HSA-388841) -6.560.0PDCD1, HLA-DQB1, HLA-DRB1
TCR signaling (R-HSA-202403) -6.640.0TNFRSF1A, HLA-DQB1, HLA-DRB1
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.184TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
signal transducer activity (GO:0004871) 2.284TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
signaling receptor activity (GO:0038023) 2.493TNFRSF1A, HLA-DQB1, HLA-DRB1
molecular transducer activity (GO:0060089) 2.323TNFRSF1A, HLA-DQB1, HLA-DRB1
transmembrane signaling receptor activity (GO:0004888) 2.573TNFRSF1A, HLA-DQB1, HLA-DRB1
receptor activity (GO:0004872) 2.323TNFRSF1A, HLA-DQB1, HLA-DRB1
protein binding (GO:0005515) 0.463TNFRSF1A, PDCD1, HLA-DRB1
transmembrane receptor activity (GO:0099600) 2.533TNFRSF1A, HLA-DQB1, HLA-DRB1
amide binding (GO:0033218) 4.142HLA-DQB1, HLA-DRB1
peptide binding (GO:0042277) 4.222HLA-DQB1, HLA-DRB1
antigen binding (GO:0003823) 5.022HLA-DQB1, HLA-DRB1
MHC class II receptor activity (GO:0032395) 7.12HLA-DQB1, HLA-DRB1
peptide antigen binding (GO:0042605) 6.182HLA-DQB1, HLA-DRB1

NET-GE enrichment

Term New enriched termICP valueGenes
signaling receptor activity (GO:0038023) -2.490.001TNFRSF1A, HLA-DQB1, HLA-DRB1
signal transducer activity (GO:0004871) -2.280.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
MHC class II receptor activity (GO:0032395) -7.10.0HLA-DQB1, HLA-DRB1
peptide antigen binding (GO:0042605) -6.180.0HLA-DQB1, HLA-DRB1
amide binding (GO:0033218) -4.140.0HLA-DQB1, HLA-DRB1
molecular transducer activity (GO:0060089) -2.320.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
transmembrane signaling receptor activity (GO:0004888) -2.570.0TNFRSF1A, HLA-DQB1, HLA-DRB1
receptor activity (GO:0004872) -2.320.002TNFRSF1A, HLA-DQB1, HLA-DRB1
antigen binding (GO:0003823) -5.020.0HLA-DQB1, HLA-DRB1
peptide binding (GO:0042277) -4.220.0HLA-DQB1, HLA-DRB1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to stimulus (GO:0050896) 1.224TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
regulation of cellular process (GO:0050794) 0.54TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
immune system process (GO:0002376) 2.294TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
biological regulation (GO:0065007) 0.394TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
signal transduction (GO:0007165) 1.284TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
immune response (GO:0006955) 2.864TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of biological process (GO:0048518) 1.24TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
regulation of biological process (GO:0050789) 0.454TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of cellular process (GO:0048522) 1.34TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
cytokine-mediated signaling pathway (GO:0019221) 3.63TNFRSF1A, HLA-DQB1, HLA-DRB1
regulation of cell activation (GO:0050865) 3.533PDCD1, HLA-DQB1, HLA-DRB1
regulation of cell adhesion (GO:0030155) 3.273PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of response to stimulus (GO:0048584) 2.183TNFRSF1A, HLA-DQB1, HLA-DRB1
regulation of response to stimulus (GO:0048583) 1.543TNFRSF1A, HLA-DQB1, HLA-DRB1
regulation of T cell activation (GO:0050863) 4.053PDCD1, HLA-DQB1, HLA-DRB1
regulation of cell-cell adhesion (GO:0022407) 3.793PDCD1, HLA-DQB1, HLA-DRB1
cell surface receptor signaling pathway (GO:0007166) 2.093TNFRSF1A, HLA-DQB1, HLA-DRB1
positive regulation of cell-cell adhesion (GO:0022409) 4.233PDCD1, HLA-DQB1, HLA-DRB1
regulation of lymphocyte activation (GO:0051249) 3.733PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of cell adhesion (GO:0045785) 3.793PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of leukocyte cell-cell adhesion (GO:1903039) 4.353PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of immune system process (GO:0002684) 2.963PDCD1, HLA-DQB1, HLA-DRB1
regulation of immune system process (GO:0002682) 2.53PDCD1, HLA-DQB1, HLA-DRB1
negative regulation of biological process (GO:0048519) 1.333TNFRSF1A, PDCD1, HLA-DRB1
positive regulation of cell activation (GO:0050867) 3.973PDCD1, HLA-DQB1, HLA-DRB1
T cell costimulation (GO:0031295) 5.353PDCD1, HLA-DQB1, HLA-DRB1
regulation of leukocyte cell-cell adhesion (GO:1903037) 4.013PDCD1, HLA-DQB1, HLA-DRB1
cellular process (GO:0009987) 0.263TNFRSF1A, PDCD1, HLA-DRB1
positive regulation of T cell activation (GO:0050870) 4.393PDCD1, HLA-DQB1, HLA-DRB1
regulation of multicellular organismal process (GO:0051239) 1.873TNFRSF1A, PDCD1, HLA-DRB1
humoral immune response (GO:0006959) 4.593PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of lymphocyte activation (GO:0051251) 4.073PDCD1, HLA-DQB1, HLA-DRB1
regulation of leukocyte activation (GO:0002694) 3.63PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of leukocyte activation (GO:0002696) 4.03PDCD1, HLA-DQB1, HLA-DRB1
lymphocyte costimulation (GO:0031294) 5.333PDCD1, HLA-DQB1, HLA-DRB1
cellular component assembly (GO:0022607) 2.142TNFRSF1A, HLA-DRB1
negative regulation of response to external stimulus (GO:0032102) 4.182TNFRSF1A, HLA-DRB1
regulation of response to external stimulus (GO:0032101) 3.062TNFRSF1A, HLA-DRB1
macromolecular complex subunit organization (GO:0043933) 2.142TNFRSF1A, HLA-DRB1
negative regulation of response to stimulus (GO:0048585) 2.522TNFRSF1A, HLA-DRB1
T cell receptor signaling pathway (GO:0050852) 4.712HLA-DQB1, HLA-DRB1
antigen processing and presentation of peptide antigen via MHC class II (GO:0002495) 5.192HLA-DQB1, HLA-DRB1
antigen processing and presentation of exogenous peptide antigen (GO:0002478) 4.632HLA-DQB1, HLA-DRB1
positive regulation of signaling (GO:0023056) 2.412TNFRSF1A, HLA-DRB1
negative regulation of defense response (GO:0031348) 4.752TNFRSF1A, HLA-DRB1
antigen receptor-mediated signaling pathway (GO:0050851) 4.432HLA-DQB1, HLA-DRB1
cell death (GO:0008219) 3.052TNFRSF1A, PDCD1
regulation of signaling (GO:0023051) 1.722TNFRSF1A, HLA-DRB1
antigen processing and presentation of peptide antigen (GO:0048002) 4.562HLA-DQB1, HLA-DRB1
humoral immune response mediated by circulating immunoglobulin (GO:0002455) 8.122HLA-DQB1, HLA-DRB1
macromolecular complex assembly (GO:0065003) 2.552TNFRSF1A, HLA-DRB1
regulation of apoptotic process (GO:0042981) 2.52TNFRSF1A, PDCD1
positive regulation of cell communication (GO:0010647) 2.412TNFRSF1A, HLA-DRB1
regulation of defense response (GO:0031347) 3.112TNFRSF1A, HLA-DRB1
antigen processing and presentation of peptide antigen via MHC class I (GO:0002474) 5.192HLA-DQB1, HLA-DRB1
negative regulation of inflammatory response (GO:0050728) 5.112TNFRSF1A, HLA-DRB1
regulation of cell communication (GO:0010646) 1.732TNFRSF1A, HLA-DRB1
immune response-regulating signaling pathway (GO:0002764) 3.722HLA-DQB1, HLA-DRB1
response to external biotic stimulus (GO:0043207) 3.132TNFRSF1A, HLA-DRB1
immune response-regulating cell surface receptor signaling pathway (GO:0002768) 3.962HLA-DQB1, HLA-DRB1
cellular component organization or biogenesis (GO:0071840) 1.222TNFRSF1A, HLA-DRB1
response to bacterium (GO:0009617) 4.182TNFRSF1A, HLA-DRB1
regulation of inflammatory response (GO:0050727) 4.032TNFRSF1A, HLA-DRB1
cellular component organization (GO:0016043) 1.242TNFRSF1A, HLA-DRB1
interspecies interaction between organisms (GO:0044419) 3.082TNFRSF1A, HLA-DRB1
regulation of programmed cell death (GO:0043067) 2.492TNFRSF1A, PDCD1
immune response-activating cell surface receptor signaling pathway (GO:0002429) 4.062HLA-DQB1, HLA-DRB1
negative regulation of immune system process (GO:0002683) 3.852PDCD1, HLA-DRB1
immune effector process (GO:0002252) 3.582HLA-DQB1, HLA-DRB1
regulation of cell proliferation (GO:0042127) 2.412TNFRSF1A, HLA-DRB1
B cell mediated immunity (GO:0019724) 6.682HLA-DQB1, HLA-DRB1
antigen processing and presentation (GO:0019882) 4.362HLA-DQB1, HLA-DRB1
protein complex assembly (GO:0006461) 2.782TNFRSF1A, HLA-DRB1
antigen processing and presentation of exogenous antigen (GO:0019884) 4.592HLA-DQB1, HLA-DRB1
viral process (GO:0016032) 3.152TNFRSF1A, HLA-DRB1
antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886) 5.212HLA-DQB1, HLA-DRB1
regulation of developmental process (GO:0050793) 2.12TNFRSF1A, PDCD1
apoptotic process (GO:0006915) 3.142TNFRSF1A, PDCD1
defense response (GO:0006952) 2.782TNFRSF1A, HLA-DRB1
programmed cell death (GO:0012501) 3.12TNFRSF1A, PDCD1
response to stress (GO:0006950) 1.82TNFRSF1A, HLA-DRB1
regulation of immune response (GO:0050776) 2.982HLA-DQB1, HLA-DRB1
single-organism cellular process (GO:0044763) 0.652TNFRSF1A, PDCD1
inflammatory response (GO:0006954) 3.642TNFRSF1A, HLA-DRB1
symbiosis, encompassing mutualism through parasitism (GO:0044403) 3.152TNFRSF1A, HLA-DRB1
production of molecular mediator of immune response (GO:0002440) 6.42HLA-DQB1, HLA-DRB1
leukocyte mediated immunity (GO:0002443) 5.312HLA-DQB1, HLA-DRB1
response to other organism (GO:0051707) 3.482TNFRSF1A, HLA-DRB1
multi-organism process (GO:0051704) 2.652TNFRSF1A, HLA-DRB1
interferon-gamma-mediated signaling pathway (GO:0060333) 5.482HLA-DQB1, HLA-DRB1
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504) 5.142HLA-DQB1, HLA-DRB1
single-organism process (GO:0044699) 0.482TNFRSF1A, PDCD1
immune response-activating signal transduction (GO:0002757) 3.82HLA-DQB1, HLA-DRB1
response to biotic stimulus (GO:0009607) 3.092TNFRSF1A, HLA-DRB1
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460) 5.572HLA-DQB1, HLA-DRB1
response to external stimulus (GO:0009605) 2.552TNFRSF1A, HLA-DRB1
lymphocyte mediated immunity (GO:0002449) 5.592HLA-DQB1, HLA-DRB1
negative regulation of multicellular organismal process (GO:0051241) 2.842PDCD1, HLA-DRB1
regulation of response to stress (GO:0080134) 2.532TNFRSF1A, HLA-DRB1
regulation of cell death (GO:0010941) 2.432TNFRSF1A, PDCD1
positive regulation of immune response (GO:0050778) 3.42HLA-DQB1, HLA-DRB1
immunoglobulin production (GO:0002377) 7.242HLA-DQB1, HLA-DRB1
immunoglobulin production involved in immunoglobulin mediated immune response (GO:0002381) 8.342HLA-DQB1, HLA-DRB1
multi-organism cellular process (GO:0044764) 3.142TNFRSF1A, HLA-DRB1
regulation of multicellular organismal development (GO:2000026) 2.312TNFRSF1A, PDCD1
adaptive immune response (GO:0002250) 4.432HLA-DQB1, HLA-DRB1
activation of immune response (GO:0002253) 3.672HLA-DQB1, HLA-DRB1
protein complex subunit organization (GO:0071822) 2.62TNFRSF1A, HLA-DRB1
immunoglobulin mediated immune response (GO:0016064) 6.92HLA-DQB1, HLA-DRB1
negative regulation of cellular process (GO:0048523) 1.412PDCD1, HLA-DRB1

NET-GE enrichment

Term New enriched termICP valueGenes
cytokine-mediated signaling pathway (GO:0019221) -3.60.0TNFRSF1A, HLA-DQB1, HLA-DRB1
positive regulation of response to stimulus (GO:0048584) -2.180.0TNFRSF1A, HLA-DQB1, HLA-DRB1
regulation of response to stimulus (GO:0048583) -1.540.0TNFRSF1A, HLA-DQB1, HLA-DRB1
signal transduction (GO:0007165) -1.280.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
cell surface receptor signaling pathway (GO:0007166) -2.090.0TNFRSF1A, HLA-DQB1, HLA-DRB1
humoral immune response mediated by circulating immunoglobulin (GO:0002455) -8.120.0HLA-DQB1, HLA-DRB1
cellular response to stimulus (GO:0051716) NEW1.970.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
response to external biotic stimulus (GO:0043207) -3.130.002TNFRSF1A, HLA-DRB1
response to bacterium (GO:0009617) -4.180.0TNFRSF1A, HLA-DRB1
regulation of leukocyte proliferation (GO:0070663) NEW4.40.0TNFRSF1A, PDCD1, HLA-DRB1
positive regulation of biological process (GO:0048518) -1.20.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
T cell costimulation (GO:0031295) -5.350.0PDCD1, HLA-DQB1, HLA-DRB1
lymphocyte costimulation (GO:0031294) -5.330.0PDCD1, HLA-DQB1, HLA-DRB1
B cell mediated immunity (GO:0019724) -6.680.0HLA-DQB1, HLA-DRB1
positive regulation of transport (GO:0051050) NEW2.90.002TNFRSF1A, HLA-DRB1
regulation of T cell proliferation (GO:0042129) NEW4.740.0TNFRSF1A, PDCD1, HLA-DRB1
response to other organism (GO:0051707) -3.480.0TNFRSF1A, HLA-DRB1
response to organic substance (GO:0010033) NEW2.20.0TNFRSF1A, HLA-DQB1, HLA-DRB1
antigen processing and presentation of peptide or polysaccharide antigen via MHC class II (GO:0002504) -5.140.0HLA-DQB1, HLA-DRB1
immune response-activating cell surface receptor signaling pathway (GO:0002429) -4.060.0HLA-DQB1, HLA-DRB1
immune system process (GO:0002376) -2.290.0PDCD1, HLA-DQB1, HLA-DRB1
immunoglobulin production (GO:0002377) -7.240.0TNFRSF1A, HLA-DQB1, HLA-DRB1
cellular component assembly (GO:0022607) -2.140.037TNFRSF1A, HLA-DRB1
regulation of interferon-gamma production (GO:0032649) NEW5.210.0TNFRSF1A, HLA-DRB1
regulation of establishment of protein localization (GO:0070201) NEW3.020.0TNFRSF1A, HLA-DRB1
regulation of mononuclear cell proliferation (GO:0032944) NEW4.450.0TNFRSF1A, PDCD1, HLA-DRB1
negative regulation of mononuclear cell proliferation (GO:0032945) NEW5.590.0PDCD1, HLA-DRB1
antigen processing and presentation of peptide antigen (GO:0048002) -4.560.0HLA-DQB1, HLA-DRB1
regulation of protein transport (GO:0051223) NEW3.120.0TNFRSF1A, HLA-DRB1
immunoglobulin production involved in immunoglobulin mediated immune response (GO:0002381) -8.340.0TNFRSF1A, HLA-DQB1, HLA-DRB1
immune response-regulating signaling pathway (GO:0002764) -3.720.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
immune response-regulating cell surface receptor signaling pathway (GO:0002768) -3.960.0PDCD1, HLA-DQB1, HLA-DRB1
macromolecular complex assembly (GO:0065003) -2.550.003TNFRSF1A, HLA-DRB1
positive regulation of immune system process (GO:0002684) -2.960.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
regulation of immune system process (GO:0002682) -2.50.0PDCD1, HLA-DQB1, HLA-DRB1
negative regulation of immune system process (GO:0002683) -3.850.024PDCD1, HLA-DRB1
antigen processing and presentation (GO:0019882) -4.360.0HLA-DQB1, HLA-DRB1
antigen processing and presentation of exogenous antigen (GO:0019884) -4.590.0HLA-DQB1, HLA-DRB1
response to cytokine (GO:0034097) NEW3.840.0TNFRSF1A, HLA-DQB1, HLA-DRB1
antigen processing and presentation of exogenous peptide antigen via MHC class II (GO:0019886) -5.210.0HLA-DQB1, HLA-DRB1
regulation of cellular process (GO:0050794) -0.50.042TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
immunoglobulin mediated immune response (GO:0016064) -6.90.0HLA-DQB1, HLA-DRB1
inflammatory response (GO:0006954) -3.640.0TNFRSF1A, HLA-DRB1
immune response (GO:0006955) -2.860.0PDCD1, HLA-DQB1, HLA-DRB1
humoral immune response (GO:0006959) -4.590.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
immune response-activating signal transduction (GO:0002757) -3.80.0TNFRSF1A, HLA-DQB1, HLA-DRB1
interferon-gamma-mediated signaling pathway (GO:0060333) -5.480.0HLA-DQB1, HLA-DRB1
cellular response to cytokine stimulus (GO:0071345) NEW4.330.0TNFRSF1A, HLA-DQB1, HLA-DRB1
response to stimulus (GO:0050896) -1.220.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
cellular response to interferon-gamma (GO:0071346) NEW5.780.0HLA-DQB1, HLA-DRB1
negative regulation of leukocyte activation (GO:0002695) NEW4.790.0PDCD1, HLA-DRB1
regulation of leukocyte activation (GO:0002694) -3.60.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of leukocyte activation (GO:0002696) -4.00.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
antigen processing and presentation of peptide antigen via MHC class II (GO:0002495) -5.190.0HLA-DQB1, HLA-DRB1
cellular response to chemical stimulus (GO:0070887) NEW2.570.0TNFRSF1A, HLA-DQB1, HLA-DRB1
regulation of protein localization (GO:0032880) NEW2.880.001TNFRSF1A, HLA-DRB1
negative regulation of multicellular organismal process (GO:0051241) -2.840.0TNFRSF1A, HLA-DRB1
macromolecular complex subunit organization (GO:0043933) -2.140.017TNFRSF1A, HLA-DRB1
positive regulation of T cell activation (GO:0050870) -4.390.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
protein oligomerization (GO:0051259) NEW3.710.0TNFRSF1A, HLA-DRB1
regulation of immune response (GO:0050776) -2.980.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains (GO:0002460) -5.570.0HLA-DQB1, HLA-DRB1
positive regulation of lymphocyte activation (GO:0051251) -4.070.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
negative regulation of lymphocyte activation (GO:0051250) NEW4.950.0PDCD1, HLA-DRB1
regulation of lymphocyte proliferation (GO:0050670) NEW4.460.0TNFRSF1A, PDCD1, HLA-DRB1
positive regulation of immune response (GO:0050778) -3.40.0TNFRSF1A, HLA-DQB1, HLA-DRB1
negative regulation of lymphocyte proliferation (GO:0050672) NEW5.590.0PDCD1, HLA-DRB1
regulation of cytokine production (GO:0001817) NEW3.40.0TNFRSF1A, HLA-DRB1
negative regulation of cytokine production (GO:0001818) NEW4.40.002TNFRSF1A, HLA-DRB1
response to biotic stimulus (GO:0009607) -3.090.003TNFRSF1A, HLA-DRB1
negative regulation of T cell activation (GO:0050868) NEW5.260.0PDCD1, HLA-DRB1
regulation of cellular localization (GO:0060341) NEW3.030.017TNFRSF1A, HLA-DRB1
regulation of cell activation (GO:0050865) -3.530.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of cell activation (GO:0050867) -3.970.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
negative regulation of cell activation (GO:0050866) NEW4.670.001PDCD1, HLA-DRB1
regulation of T cell activation (GO:0050863) -4.050.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
negative regulation of T cell proliferation (GO:0042130) NEW5.820.0PDCD1, HLA-DRB1
protein complex subunit organization (GO:0071822) -2.60.007TNFRSF1A, HLA-DRB1
antigen processing and presentation of exogenous peptide antigen (GO:0002478) -4.630.0HLA-DQB1, HLA-DRB1
cellular response to organic substance (GO:0071310) NEW2.780.0TNFRSF1A, HLA-DQB1, HLA-DRB1
negative regulation of leukocyte proliferation (GO:0070664) NEW5.520.0PDCD1, HLA-DRB1
antigen receptor-mediated signaling pathway (GO:0050851) -4.430.0HLA-DQB1, HLA-DRB1
T cell receptor signaling pathway (GO:0050852) -4.710.0HLA-DQB1, HLA-DRB1
protein complex assembly (GO:0006461) -2.780.001TNFRSF1A, HLA-DRB1
response to interferon-gamma (GO:0034341) NEW5.40.0HLA-DQB1, HLA-DRB1
lymphocyte mediated immunity (GO:0002449) -5.590.0HLA-DQB1, HLA-DRB1
production of molecular mediator of immune response (GO:0002440) -6.40.0TNFRSF1A, HLA-DQB1, HLA-DRB1
response to chemical (GO:0042221) NEW1.980.0TNFRSF1A, HLA-DQB1, HLA-DRB1
leukocyte mediated immunity (GO:0002443) -5.310.0HLA-DQB1, HLA-DRB1
adaptive immune response (GO:0002250) -4.430.0HLA-DQB1, HLA-DRB1
activation of immune response (GO:0002253) -3.670.0TNFRSF1A, HLA-DQB1, HLA-DRB1
immune effector process (GO:0002252) -3.580.0TNFRSF1A, HLA-DQB1, HLA-DRB1
regulation of lymphocyte activation (GO:0051249) -3.730.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
positive regulation of cellular process (GO:0048522) -1.30.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
integral component of membrane (GO:0016021) 1.144TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
membrane (GO:0016020) 0.684TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
cell part (GO:0044464) 0.114TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
plasma membrane (GO:0005886) 1.394TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
membrane part (GO:0044425) 0.954TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
plasma membrane part (GO:0044459) 1.954TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
intrinsic component of membrane (GO:0031224) 1.134TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
protein complex (GO:0043234) 1.513TNFRSF1A, HLA-DQB1, HLA-DRB1
Golgi apparatus (GO:0005794) 2.73TNFRSF1A, HLA-DQB1, HLA-DRB1
macromolecular complex (GO:0032991) 1.353TNFRSF1A, HLA-DQB1, HLA-DRB1
organelle membrane (GO:0031090) 1.973TNFRSF1A, HLA-DQB1, HLA-DRB1
cytoplasmic part (GO:0044444) 0.823TNFRSF1A, HLA-DQB1, HLA-DRB1
bounding membrane of organelle (GO:0098588) 2.393TNFRSF1A, HLA-DQB1, HLA-DRB1
Golgi apparatus part (GO:0044431) 3.03TNFRSF1A, HLA-DQB1, HLA-DRB1
Golgi membrane (GO:0000139) 3.283TNFRSF1A, HLA-DQB1, HLA-DRB1
intracellular organelle part (GO:0044446) 0.813TNFRSF1A, HLA-DQB1, HLA-DRB1
intracellular organelle (GO:0043229) 0.513TNFRSF1A, HLA-DQB1, HLA-DRB1
intracellular part (GO:0044424) 0.283TNFRSF1A, HLA-DQB1, HLA-DRB1
membrane-bounded organelle (GO:0043227) 0.473TNFRSF1A, HLA-DQB1, HLA-DRB1
organelle (GO:0043226) 0.43TNFRSF1A, HLA-DQB1, HLA-DRB1
organelle part (GO:0044422) 0.793TNFRSF1A, HLA-DQB1, HLA-DRB1
intracellular membrane-bounded organelle (GO:0043231) 0.63TNFRSF1A, HLA-DQB1, HLA-DRB1
external side of plasma membrane (GO:0009897) 4.462PDCD1, HLA-DRB1
membrane protein complex (GO:0098796) 2.842HLA-DQB1, HLA-DRB1
lytic vacuole (GO:0000323) 3.892HLA-DQB1, HLA-DRB1
endoplasmic reticulum (GO:0005783) 2.562HLA-DQB1, HLA-DRB1
endoplasmic reticulum membrane (GO:0005789) 2.952HLA-DQB1, HLA-DRB1
integral component of endoplasmic reticulum membrane (GO:0030176) 5.012HLA-DQB1, HLA-DRB1
side of membrane (GO:0098552) 4.222PDCD1, HLA-DRB1
integral component of plasma membrane (GO:0005887) 2.572TNFRSF1A, HLA-DRB1
intrinsic component of plasma membrane (GO:0031226) 2.532TNFRSF1A, HLA-DRB1
intrinsic component of endoplasmic reticulum membrane (GO:0031227) 4.972HLA-DQB1, HLA-DRB1
endosome membrane (GO:0010008) 3.832HLA-DQB1, HLA-DRB1
clathrin-coated vesicle membrane (GO:0030665) 5.62HLA-DQB1, HLA-DRB1
lysosome (GO:0005764) 3.892HLA-DQB1, HLA-DRB1
endocytic vesicle membrane (GO:0030666) 4.822HLA-DQB1, HLA-DRB1
extracellular space (GO:0005615) 2.632TNFRSF1A, HLA-DRB1
coated vesicle membrane (GO:0030662) 5.02HLA-DQB1, HLA-DRB1
vacuole (GO:0005773) 2.922HLA-DQB1, HLA-DRB1
whole membrane (GO:0098805) 2.852HLA-DQB1, HLA-DRB1
clathrin-coated endocytic vesicle membrane (GO:0030669) 6.092HLA-DQB1, HLA-DRB1
vacuolar membrane (GO:0005774) 3.452HLA-DQB1, HLA-DRB1
cytoplasmic vesicle part (GO:0044433) 3.412HLA-DQB1, HLA-DRB1
endoplasmic reticulum part (GO:0044432) 2.732HLA-DQB1, HLA-DRB1
integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) 6.432HLA-DQB1, HLA-DRB1
vacuolar part (GO:0044437) 3.262HLA-DQB1, HLA-DRB1
cell surface (GO:0009986) 3.442TNFRSF1A, HLA-DRB1
transport vesicle membrane (GO:0030658) 4.862HLA-DQB1, HLA-DRB1
cytoplasmic vesicle membrane (GO:0030659) 3.672HLA-DQB1, HLA-DRB1
trans-Golgi network membrane (GO:0032588) 5.42HLA-DQB1, HLA-DRB1
vesicle membrane (GO:0012506) 3.632HLA-DQB1, HLA-DRB1
ER to Golgi transport vesicle membrane (GO:0012507) 5.812HLA-DQB1, HLA-DRB1
MHC protein complex (GO:0042611) 6.432HLA-DQB1, HLA-DRB1
MHC class II protein complex (GO:0042613) 6.812HLA-DQB1, HLA-DRB1
MHC class I protein complex (GO:0042612) 7.242HLA-DQB1, HLA-DRB1
plasma membrane protein complex (GO:0098797) 3.552HLA-DQB1, HLA-DRB1
lysosomal membrane (GO:0005765) 4.192HLA-DQB1, HLA-DRB1
endosomal part (GO:0044440) 3.732HLA-DQB1, HLA-DRB1
endosome (GO:0005768) 3.252HLA-DQB1, HLA-DRB1
extracellular region part (GO:0044421) 1.572TNFRSF1A, HLA-DRB1
lytic vacuole membrane (GO:0098852) 4.192HLA-DQB1, HLA-DRB1

NET-GE enrichment

Term New enriched termICP valueGenes
external side of plasma membrane (GO:0009897) -4.460.0TNFRSF1A, PDCD1, HLA-DRB1
plasma membrane (GO:0005886) -1.390.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
integral component of endoplasmic reticulum membrane (GO:0030176) -5.010.0HLA-DQB1, HLA-DRB1
integral component of organelle membrane (GO:0031301) NEW4.850.0HLA-DQB1, HLA-DRB1
side of membrane (GO:0098552) -4.220.0TNFRSF1A, PDCD1, HLA-DRB1
endosome membrane (GO:0010008) -3.830.0TNFRSF1A, HLA-DQB1, HLA-DRB1
clathrin-coated vesicle membrane (GO:0030665) -5.60.0HLA-DQB1, HLA-DRB1
endocytic vesicle membrane (GO:0030666) -4.820.0HLA-DQB1, HLA-DRB1
organelle membrane (GO:0031090) -1.970.0TNFRSF1A, HLA-DQB1, HLA-DRB1
coated vesicle membrane (GO:0030662) -5.00.0HLA-DQB1, HLA-DRB1
integral component of membrane (GO:0016021) -1.140.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
membrane (GO:0016020) -0.680.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
clathrin-coated endocytic vesicle membrane (GO:0030669) -6.090.0HLA-DQB1, HLA-DRB1
Golgi apparatus part (GO:0044431) -3.00.0TNFRSF1A, HLA-DQB1, HLA-DRB1
vacuolar membrane (GO:0005774) -3.450.0HLA-DQB1, HLA-DRB1
cytoplasmic vesicle part (GO:0044433) -3.410.0HLA-DQB1, HLA-DRB1
endoplasmic reticulum part (GO:0044432) -2.730.0TNFRSF1A, HLA-DQB1, HLA-DRB1
integral component of lumenal side of endoplasmic reticulum membrane (GO:0071556) -6.430.0HLA-DQB1, HLA-DRB1
vacuolar part (GO:0044437) -3.260.0HLA-DQB1, HLA-DRB1
plasma membrane part (GO:0044459) -1.950.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
protein complex (GO:0043234) -1.510.011TNFRSF1A, HLA-DQB1, HLA-DRB1
bounding membrane of organelle (GO:0098588) -2.390.0TNFRSF1A, HLA-DQB1, HLA-DRB1
transport vesicle membrane (GO:0030658) -4.860.0HLA-DQB1, HLA-DRB1
cytoplasmic vesicle membrane (GO:0030659) -3.670.0HLA-DQB1, HLA-DRB1
trans-Golgi network membrane (GO:0032588) -5.40.0HLA-DQB1, HLA-DRB1
vesicle membrane (GO:0012506) -3.630.0HLA-DQB1, HLA-DRB1
ER to Golgi transport vesicle membrane (GO:0012507) -5.810.0HLA-DQB1, HLA-DRB1
MHC protein complex (GO:0042611) -6.430.0HLA-DQB1, HLA-DRB1
MHC class II protein complex (GO:0042613) -6.810.0HLA-DQB1, HLA-DRB1
macromolecular complex (GO:0032991) -1.350.002TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
Golgi membrane (GO:0000139) -3.280.0TNFRSF1A, HLA-DQB1, HLA-DRB1
intracellular organelle part (GO:0044446) -0.810.0TNFRSF1A, HLA-DQB1, HLA-DRB1
lysosomal membrane (GO:0005765) -4.190.0HLA-DQB1, HLA-DRB1
cytoplasmic part (GO:0044444) -0.820.001TNFRSF1A, HLA-DQB1, HLA-DRB1
endosomal part (GO:0044440) -3.730.0TNFRSF1A, HLA-DQB1, HLA-DRB1
membrane part (GO:0044425) -0.950.0TNFRSF1A, PDCD1, HLA-DQB1, HLA-DRB1
organelle part (GO:0044422) -0.790.001TNFRSF1A, HLA-DQB1, HLA-DRB1