| Disease ID | Disease name | Source of annotation with HLA-DRB1 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS126200 | MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO | OMIM | link to OMIM | 4 | HLA-DRB1, PDCD1, HLA-DQB1, TNFRSF1A |
| 181000 | SARCOIDOSIS, SUSCEPTIBILITY TO, 1 | ClinVar, OMIM | link to OMIM | 1 | HLA-DRB1 |
| 180300 | RHEUMATOID ARTHRITIS | OMIM | link to OMIM | 9 | IL10, PTPN22, SLC22A4, PADI4, HLA-DRB1, NFKBIL1, IRF5, CIITA, CD244 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Antigen processing and presentation | hsa04612 | 6.04 |
| Allograft rejection | hsa05330 | 6.91 |
| Graft-versus-host disease | hsa05332 | 6.84 |
| Intestinal immune network for IgA production | hsa04672 | 6.79 |
| Cell adhesion molecules (CAMs) | hsa04514 | 5.36 |
| Phagosome | hsa04145 | 5.27 |
| Asthma | hsa05310 | 7.34 |
| Type I diabetes mellitus | hsa04940 | 6.79 |
| Viral myocarditis | hsa05416 | 6.45 |
| Leishmaniasis | hsa05140 | 6.32 |
| Herpes simplex infection | hsa05168 | 5.08 |
| Epstein-Barr virus infection | hsa05169 | 4.97 |
| Toxoplasmosis | hsa05145 | 5.71 |
| Influenza A | hsa05164 | 5.21 |
| HTLV-I infection | hsa05166 | 4.59 |
| Systemic lupus erythematosus | hsa05322 | 5.95 |
| Rheumatoid arthritis | hsa05323 | 6.05 |
| Autoimmune thyroid disease | hsa05320 | 6.62 |
| Inflammatory bowel disease (IBD) | hsa05321 | 6.43 |
| Hematopoietic cell lineage | hsa04640 | 6.18 |
| Staphylococcus aureus infection | hsa05150 | 6.64 |
| Tuberculosis | hsa05152 | 5.17 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Generation of second messenger molecules | R-HSA-202433 | 7.34 |
| PD-1 signaling | R-HSA-389948 | 7.62 |
| Translocation of ZAP-70 to Immunological synapse | R-HSA-202430 | 7.81 |
| Downstream TCR signaling | R-HSA-202424 | 7.01 |
| Phosphorylation of CD3 and TCR zeta chains | R-HSA-202427 | 7.73 |
| Immune System | R-HSA-168256 | 2.37 |
| TCR signaling | R-HSA-202403 | 6.64 |
| Cytokine Signaling in Immune system | R-HSA-1280215 | 3.74 |
| Interferon gamma signaling | R-HSA-877300 | 5.67 |
| MHC class II antigen presentation | R-HSA-2132295 | 6.01 |
| Interferon Signaling | R-HSA-913531 | 4.95 |
| Costimulation by the CD28 family | R-HSA-388841 | 6.56 |
| Adaptive Immune System | R-HSA-1280218 | 3.19 |
| GO term | GO ID | GO IC |
|---|---|---|
| antigen binding | GO:0003823 | 5.02 |
| signaling receptor activity | GO:0038023 | 2.49 |
| protein binding | GO:0005515 | 0.46 |
| MHC class II receptor activity | GO:0032395 | 7.1 |
| peptide antigen binding | GO:0042605 | 6.18 |
| amide binding | GO:0033218 | 4.14 |
| virus receptor activity | GO:0001618 | 5.49 |
| MHC protein complex binding | GO:0023023 | 6.79 |
| molecular transducer activity | GO:0060089 | 2.32 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| protein complex binding | GO:0032403 | 3.09 |
| peptide binding | GO:0042277 | 4.22 |
| receptor activity | GO:0004872 | 2.32 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| MHC class II protein complex binding | GO:0023026 | 6.97 |