Gene table of TRPM4 : transient receptor potential cation channel subfamily M member 4

Gene-disease associations table

Disease ID	Disease name	Source of annotation with TRPM4	OMIM link	Number of associated genes	genes
PS113900	PROGRESSIVE FAMILIAL HEART BLOCK	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	SCN5A, TRPM4
PS604772	VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC	ClinVar	link to OMIM	15	DSP, MYBPC3, TPM1, SCN5A, DMPK, LMNA, CALM1, TRDN, RYR2, ANK2, TRPM4, KCNH2, LAMA4, CASQ2, DSG2

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Annotation of the gene TRPM4

Associated genes in ENSEMBL

ENSG00000130529

Associated proteins - SwissProt Accession ID

Q8TD43

Associated PDB IDs

Cytogenetic Band

19q13.33

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Insulin secretion	hsa04911	6.18

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
TRP channels	R-HSA-3295583	8.18
Ion channel transport	R-HSA-983712	5.34
Transmembrane transport of small molecules	R-HSA-382551	3.79
Stimuli-sensing channels	R-HSA-2672351	6.28

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cation channel activity	GO:0005261	4.04
calcium channel activity	GO:0005262	5.03
purine ribonucleoside triphosphate binding	GO:0035639	2.22
calcium activated cation channel activity	GO:0005227	6.41
binding	GO:0005488	0.18
divalent inorganic cation transmembrane transporter activity	GO:0072509	4.62
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
calcium ion transmembrane transporter activity	GO:0015085	4.89
sodium ion transmembrane transporter activity	GO:0015081	4.83
transmembrane transporter activity	GO:0022857	2.82
nucleotide binding	GO:0000166	1.96
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
passive transmembrane transporter activity	GO:0022803	3.6
metal ion transmembrane transporter activity	GO:0046873	3.71
ATP binding	GO:0005524	2.43
calmodulin binding	GO:0005516	4.55
sodium channel activity	GO:0005272	6.13
transporter activity	GO:0005215	2.57
ion channel activity	GO:0005216	3.71
cation transmembrane transporter activity	GO:0008324	3.32
small molecule binding	GO:0036094	1.89
purine nucleotide binding	GO:0017076	2.19
substrate-specific transmembrane transporter activity	GO:0022891	2.9
inorganic cation transmembrane transporter activity	GO:0022890	3.49
substrate-specific transporter activity	GO:0022892	2.72
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
ion transmembrane transporter activity	GO:0015075	3.04
monovalent inorganic cation transmembrane transporter activity	GO:0015077	3.87
channel activity	GO:0015267	3.6
adenyl ribonucleotide binding	GO:0032559	2.41
gated channel activity	GO:0022836	3.96
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
ion gated channel activity	GO:0022839	5.98
substrate-specific channel activity	GO:0022838	3.67
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19