Disease table of VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC OMIM ID: PS604772

Gene-disease associations table

Gene	Associated with VENTRICULAR TACHYCARDIA, CATECHOLAMINERGIC POLYMORPHIC in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
TRDN	ClinVar, OMIM, HUMSAVAR	HGNC link	6q22.31	1	PS604772
RYR2	ClinVar, OMIM, HUMSAVAR	HGNC link	1q43	4	115000, PS604772, PS107970, 603829
LAMA4	ClinVar	HGNC link	6q21	2	PS115200, PS604772
CASQ2	ClinVar, OMIM, HUMSAVAR	HGNC link	1p13.1	2	115000, PS604772
CALM1	ClinVar, OMIM, HUMSAVAR	HGNC link	14q32.11	2	PS192500, PS604772
DSP	ClinVar	HGNC link	6p24.3	8	607655, 615821, PS604772, 609638, 612908, 605676, PS107970, 603829
TRPM4	ClinVar	HGNC link	19q13.33	2	PS113900, PS604772
ANK2	ClinVar	HGNC link	4q25	3	PS192500, PS604772, 115000
MYBPC3	ClinVar	HGNC link	11p11.2	4	PS604169, PS604772, PS115200, PS192600
TPM1	ClinVar	HGNC link	15q22.2	4	PS604169, PS604772, PS115200, PS192600
DMPK	ClinVar	HGNC link	19q13.32	2	PS604772, PS160900
DSG2	ClinVar	HGNC link	18q12.1	4	115000, PS604772, PS115200, PS107970
LMNA	ClinVar	HGNC link	1q22	12	212112, PS310300, PS248370, PS176670, PS118220, PS604772, PS159000, PS115200, 613205, 275210, 610140, PS151660
SCN5A	ClinVar	HGNC link	3p22.2	11	272120, 108770, PS113900, PS604772, PS608583, PS192500, PS115200, 603829, 115000, PS601144, PS608567
KCNH2	ClinVar	HGNC link	7q36.1	6	272120, 603829, PS609620, PS604772, 115000, PS192500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
19q13	2	TRPM4, DMPK

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
6q2	2	TRDN, LAMA4
19q1	2	TRPM4, DMPK

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
1q	2	LMNA, RYR2
19q	2	TRPM4, DMPK
6q	2	TRDN, LAMA4

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
19	2	TRPM4, DMPK
1	3	LMNA, CASQ2, RYR2
6	3	TRDN, LAMA4, DSP

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
DMPK	YES	1	SPEN	0
KCNH2	YES	1	SP1	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
TRDN	RYR2	No	2	CALM1, RYR1
TRDN	CASQ2	Yes	0
TRDN	CALM1	Yes	0
TRDN	SCN5A	No	1	CALM1
RYR2	CALM1	Yes	4	CACNA1C, AKAP6, RYR2, PPP1CB
RYR2	MYBPC3	No	1	HSPB2
RYR2	TPM1	No	2	PPP1CB, HOMER1
RYR2	DMPK	No	1	HSPB2
RYR2	LMNA	No	1	PPP1CC
RYR2	SCN5A	No	3	SNTA1, CALM1, ALB
LAMA4	TRPM4	No	1	LGALS8
LAMA4	ANK2	No	1	TP53
LAMA4	TPM1	No	1	TP53
LAMA4	LMNA	No	1	TP53
CASQ2	CALM1	No	2	MYCBP2, TRDN
CASQ2	DSP	No	3	OBSL1, CUL7, CCDC8
CASQ2	TPM1	No	1	ACTA2
CASQ2	DSG2	No	3	OBSL1, CUL7, CCDC8
CASQ2	LMNA	No	3	OBSL1, CUL7, CCDC8
CALM1	DSP	No	5	CUL3, UCHL5, MCM2, CDC5L, PTEN
CALM1	MYBPC3	No	2	TTN, CUL1
CALM1	TPM1	No	25	ANLN, MYH9, EGFR, SF3B1, LIMA1, PAN2, SP1, IQGAP1, NEB, MYO18A, DBN1, LRRK2, SCLT1, ELAVL1, PPP1CB, TMOD3, MYO1C, CORO1C, CALML3, PDLIM7, CNN1, UBC, MYH10, YWHAQ, FLNA
CALM1	DMPK	No	1	HSP90AA1
CALM1	DSG2	No	14	ADRB2, EGFR, CORO1C, FLNA, IQGAP1, MYO18A, PPP1CB, MYH9, FLNB, TMOD3, MYH10, LIMA1, PAN2, DBN1
CALM1	LMNA	No	15	MYC, FLNA, CDC5L, MORF4L1, RANBP2, ANLN, MCM2, HERC2, DDX3X, SVIL, UCHL5, NXF1, YWHAQ, H2AFX, MOV10
CALM1	SCN5A	Yes	0
CALM1	KCNH2	No	5	HSPA4, FKBP8, YWHAE, CUL1, HSP90AA1
DSP	ANK2	No	1	NTRK1
DSP	TPM1	No	2	SASS6, CDK2
DSP	DSG2	No	8	OBSL1, EED, CCDC8, JUP, CUL7, DSC1, PKP2, PKP3
DSP	LMNA	No	19	SIRT6, HIST1H3E, WWOX, HNRNPA1, VCP, CDC5L, EED, CDK2, MCM2, RPA1, OBSL1, MCM5, CCDC8, SIRT7, PRKCA, NTRK1, SNW1, UCHL5, CUL7
DSP	SCN5A	No	1	CDK2
DSP	KCNH2	No	1	NTRK1
TRPM4	LMNA	No	1	FUS
ANK2	TPM1	No	1	TP53
ANK2	DSG2	No	1	ABCE1
ANK2	LMNA	No	3	NTRK1, ABCE1, TP53
ANK2	KCNH2	No	1	NTRK1
MYBPC3	DMPK	No	1	HSPB2
MYBPC3	KCNH2	No	1	CUL1
TPM1	DSG2	No	13	IQGAP1, EGFR, CORO1C, ACTB, FLNA, MYO18A, MYO19, MYH9, PAN2, TMOD3, MYH10, SYNPO, DBN1
TPM1	LMNA	No	7	CDK2, ANLN, PARK2, MDC1, TP53, YWHAQ, FLNA
TPM1	SCN5A	No	1	CDK2
TPM1	KCNH2	No	1	STUB1
DMPK	KCNH2	No	1	HSP90AA1
DSG2	LMNA	No	6	OBSL1, EED, FLNA, ABCE1, CCDC8, CUL7
LMNA	SCN5A	No	1	CDK2
LMNA	KCNH2	No	1	NTRK1
SCN5A	KCNH2	No	1	CAV3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
TRDN	RYR2	Yes	activation, binding	2	CASQ2, ASPH
TRDN	CASQ2	Yes	binding	2	RYR2, ASPH
TRDN	CALM1	No	-	1	RYR2
RYR2	CASQ2	Yes	activation, binding	2	ASPH, TRDN
RYR2	CALM1	Yes	activation, binding	8	NOS1, CAMK2A, PPP1CA, PPP1CB, CAMK2D, PPP1CC, CAMK2B, CAMK2G
CASQ2	CALM1	No	-	1	RYR2
CALM1	DSP	No	-	1	UBC
CALM1	MYBPC3	No	-	2	TTN, TNNI2
CALM1	TPM1	No	-	5	UBC, TTN, TNNI2, CNN1, CALD1
CALM1	DSG2	No	-	1	UBC
DSP	TPM1	No	-	1	UBC
DSP	DSG2	No	-	4	UBC, JUP, PKP2, PKP3
MYBPC3	TPM1	Yes	binding	32	TMOD1, TNNI1, MYL4, TNNT3, VIM, MYL3, MYH1, MYL6B, TPM2, MYL1, MYH11, MYH3, MYBPC2, MYH14, NEB, TNNC2, MYH6, MYH8, TNNT1, TNNI3, MYL9, MYH7, TNNT2, MYBPC1, ACTN2, MYL2, TTN, DES, TPM3, TNNC1, TNNI2, TPM4
TPM1	DSG2	No	-	1	UBC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
CALM1	LMNA	No	-	1	NPM1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
CALM1	SCN5A	Yes	5	CALM1, CALM3, CALM2, SCN5A, CALM1; CALM2; CALM3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Hypertrophic cardiomyopathy (HCM)	hsa05410	6.21	4	RYR2, MYBPC3, LMNA, TPM1
Arrhythmogenic right ventricular cardiomyopathy (ARVC)	hsa05412	6.32	4	DSP, RYR2, LMNA, DSG2
Dilated cardiomyopathy	hsa05414	6.08	4	RYR2, MYBPC3, LMNA, TPM1
Adrenergic signaling in cardiomyocytes	hsa04261	5.44	4	CALM1, RYR2, SCN5A, TPM1
Calcium signaling pathway	hsa04020	5.22	2	RYR2, CALM1
cAMP signaling pathway	hsa04024	5.05	2	RYR2, CALM1
Insulin secretion	hsa04911	6.18	2	TRPM4, RYR2
Circadian entrainment	hsa04713	6.11	2	RYR2, CALM1
Cardiac muscle contraction	hsa04260	6.34	2	RYR2, TPM1
Oxytocin signaling pathway	hsa04921	5.4	2	RYR2, CALM1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Cardiovascular diseases	NEW	5.06	0.0	RYR2, CALM1, TPM1, DSG2, LMNA, MYBPC3, DSP
Insulin secretion (hsa04911)	-	6.18	0.025	TRPM4, CALM1, RYR2, ANK2
Circulatory system	NEW	4.63	0.046	RYR2, SCN5A, KCNH2, TPM1, ANK2, CALM1
Hypertrophic cardiomyopathy (HCM) (hsa05410)	-	6.21	0.0	RYR2, CALM1, MYBPC3, LMNA, TPM1
Arrhythmogenic right ventricular cardiomyopathy (ARVC) (hsa05412)	-	6.32	0.0	DSP, RYR2, CALM1, LMNA, DSG2
Dilated cardiomyopathy (hsa05414)	-	6.08	0.001	RYR2, CALM1, MYBPC3, LMNA, TPM1
Adrenergic signaling in cardiomyocytes (hsa04261)	-	5.44	0.005	RYR2, CALM1, KCNH2, TPM1, ANK2, SCN5A

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Ion channel transport	R-HSA-983712	5.34	4	TRPM4, CASQ2, RYR2, TRDN
Transmembrane transport of small molecules	R-HSA-382551	3.79	4	TRPM4, CASQ2, RYR2, TRDN
Stimuli-sensing channels	R-HSA-2672351	6.28	4	TRPM4, CASQ2, RYR2, TRDN
Apoptotic cleavage of cellular proteins	R-HSA-111465	7.73	3	DSP, LMNA, DSG2
Apoptotic execution phase	R-HSA-75153	7.28	3	DSP, LMNA, DSG2
Muscle contraction	R-HSA-397014	6.96	3	MYBPC3, CALM1, TPM1
Programmed Cell Death	R-HSA-5357801	5.65	3	DSP, LMNA, DSG2
Apoptosis	R-HSA-109581	5.68	3	DSP, LMNA, DSG2
Axon guidance	R-HSA-422475	3.93	3	CALM1, SCN5A, ANK2
Developmental Biology	R-HSA-1266738	3.48	3	CALM1, SCN5A, ANK2
L1CAM interactions	R-HSA-373760	6.19	2	SCN5A, ANK2
Interaction between L1 and Ankyrins	R-HSA-445095	8.03	2	SCN5A, ANK2
Striated Muscle Contraction	R-HSA-390522	7.81	2	MYBPC3, TPM1
Neuronal System	R-HSA-112316	4.82	2	KCNH2, CALM1
Apoptotic cleavage of cell adhesion proteins	R-HSA-351906	9.52	2	DSP, DSG2
Smooth Muscle Contraction	R-HSA-445355	8.23	2	TPM1, CALM1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Apoptotic cleavage of cellular proteins (R-HSA-111465)	-	7.73	0.022	DSP, LMNA, DSG2
Ion channel transport (R-HSA-983712)	-	5.34	0.05	RYR2, CALM1, TRPM4, TRDN, CASQ2, DMPK
Interaction between L1 and Ankyrins (R-HSA-445095)	-	8.03	0.005	CALM1, SCN5A, ANK2
Apoptotic execution phase (R-HSA-75153)	-	7.28	0.014	DSP, LMNA, DSG2
Muscle contraction (R-HSA-397014)	-	6.96	0.028	MYBPC3, CALM1, TPM1
Stimuli-sensing channels (R-HSA-2672351)	-	6.28	0.004	CALM1, TRPM4, CASQ2, RYR2, TRDN
Apoptotic cleavage of cell adhesion proteins (R-HSA-351906)	-	9.52	0.025	DSP, DSG2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	15	RYR2, SCN5A, CASQ2, DSG2, LAMA4, KCNH2, TPM1, TRDN, LMNA, DMPK, ANK2, CALM1, MYBPC3, TRPM4, DSP
protein binding (GO:0005515)	0.46	15	RYR2, SCN5A, CASQ2, DSG2, LAMA4, KCNH2, TPM1, TRDN, LMNA, DMPK, ANK2, CALM1, MYBPC3, TRPM4, DSP
enzyme binding (GO:0019899)	2.27	7	RYR2, CALM1, LMNA, KCNH2, ANK2, SCN5A, DSP
cation binding (GO:0043169)	1.4	6	RYR2, CALM1, DSG2, CASQ2, MYBPC3, DMPK
metal ion binding (GO:0046872)	1.41	6	RYR2, CALM1, DSG2, CASQ2, MYBPC3, DMPK
structural molecule activity (GO:0005198)	3.1	6	TPM1, ANK2, LAMA4, LMNA, MYBPC3, DSP
ion binding (GO:0043167)	1.36	6	RYR2, CALM1, DSG2, CASQ2, MYBPC3, DMPK
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	5	CALM1, KCNH2, TRPM4, SCN5A, RYR2
ion transmembrane transporter activity (GO:0015075)	3.04	5	CALM1, TRPM4, SCN5A, RYR2, KCNH2
substrate-specific transporter activity (GO:0022892)	2.72	5	CALM1, KCNH2, TRPM4, SCN5A, RYR2
cytoskeletal protein binding (GO:0008092)	3.02	5	CALM1, MYBPC3, SCN5A, TPM1, ANK2
transporter activity (GO:0005215)	2.57	5	CALM1, KCNH2, TRPM4, SCN5A, RYR2
ion channel activity (GO:0005216)	3.71	5	CALM1, RYR2, SCN5A, TRPM4, KCNH2
protein kinase binding (GO:0019901)	3.44	5	CALM1, RYR2, SCN5A, DSP, ANK2
kinase binding (GO:0019900)	3.32	5	CALM1, RYR2, SCN5A, DSP, ANK2
transmembrane transporter activity (GO:0022857)	2.82	5	CALM1, KCNH2, TRPM4, SCN5A, RYR2
channel activity (GO:0015267)	3.6	5	SCN5A, TRPM4, CALM1, RYR2, KCNH2
gated channel activity (GO:0022836)	3.96	5	CALM1, RYR2, SCN5A, TRPM4, KCNH2
passive transmembrane transporter activity (GO:0022803)	3.6	5	SCN5A, TRPM4, CALM1, RYR2, KCNH2
ion channel binding (GO:0044325)	5.02	5	SCN5A, RYR2, CALM1, ANK2, TRDN
substrate-specific channel activity (GO:0022838)	3.67	5	CALM1, KCNH2, TRPM4, SCN5A, RYR2
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	4	KCNH2, TRPM4, SCN5A, RYR2
cation channel activity (GO:0005261)	4.04	4	KCNH2, TRPM4, SCN5A, RYR2
organic cyclic compound binding (GO:0097159)	1.05	4	DSP, TRPM4, RYR2, DMPK
cation transmembrane transporter activity (GO:0008324)	3.32	4	KCNH2, TRPM4, SCN5A, RYR2
calcium ion binding (GO:0005509)	3.17	4	CASQ2, RYR2, CALM1, DSG2
metal ion transmembrane transporter activity (GO:0046873)	3.71	4	KCNH2, TRPM4, SCN5A, RYR2
identical protein binding (GO:0042802)	2.63	4	CASQ2, RYR2, KCNH2, MYBPC3
protein binding, bridging (GO:0030674)	4.68	3	DSP, ANK2, TRDN
ligand-gated channel activity (GO:0022834)	4.8	3	CALM1, RYR2, KCNH2
catalytic activity (GO:0003824)	1.05	3	CALM1, KCNH2, DMPK
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	3	CALM1, KCNH2, DMPK
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	3	CALM1, KCNH2, DMPK
enzyme regulator activity (GO:0030234)	2.85	3	MYBPC3, CALM1, DMPK
kinase activity (GO:0016301)	2.93	3	CALM1, KCNH2, DMPK
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	3	KCNH2, TRPM4, SCN5A
ligand-gated ion channel activity (GO:0015276)	4.8	3	KCNH2, RYR2, CALM1
molecular transducer activity (GO:0060089)	2.32	3	CALM1, RYR2, KCNH2
transferase activity (GO:0016740)	1.95	3	KCNH2, CALM1, DMPK
structural constituent of cytoskeleton (GO:0005200)	5.12	3	TPM1, DSP, ANK2
scaffold protein binding (GO:0097110)	5.93	3	KCNH2, SCN5A, DSP
protein domain specific binding (GO:0019904)	3.32	3	CALM1, KCNH2, SCN5A
calmodulin binding (GO:0005516)	4.55	3	TRPM4, SCN5A, RYR2
receptor activity (GO:0004872)	2.32	3	KCNH2, RYR2, CALM1
receptor binding (GO:0005102)	2.43	3	LAMA4, CALM1, TRDN
molecular function regulator (GO:0098772)	2.51	3	MYBPC3, CALM1, DMPK
heterocyclic compound binding (GO:1901363)	1.06	3	TRPM4, DSP, DMPK
transmembrane receptor activity (GO:0099600)	2.53	3	KCNH2, RYR2, CALM1
binding, bridging (GO:0060090)	4.57	3	DSP, ANK2, TRDN
ubiquitin-like protein ligase binding (GO:0044389)	4.15	2	KCNH2, SCN5A
protein binding involved in cell adhesion (GO:0098631)	6.91	2	DSP, DSG2
protein binding involved in cell-cell adhesion (GO:0098632)	7.34	2	DSP, DSG2
calcium channel activity (GO:0005262)	5.03	2	TRPM4, RYR2
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	2	TRPM4, DMPK
phosphatase regulator activity (GO:0019208)	5.26	2	CALM1, DMPK
enzyme activator activity (GO:0008047)	3.56	2	MYBPC3, CALM1
signal transducer activity (GO:0004871)	2.28	2	RYR2, KCNH2
signaling receptor activity (GO:0038023)	2.49	2	RYR2, KCNH2
divalent inorganic cation transmembrane transporter activity (GO:0072509)	4.62	2	TRPM4, RYR2
nucleoside phosphate binding (GO:1901265)	1.96	2	TRPM4, DMPK
nucleoside binding (GO:0001882)	2.21	2	TRPM4, DMPK
calcium ion transmembrane transporter activity (GO:0015085)	4.89	2	TRPM4, RYR2
sodium ion transmembrane transporter activity (GO:0015081)	4.83	2	TRPM4, SCN5A
calcium-dependent protein binding (GO:0048306)	5.68	2	CASQ2, CALM1
nucleotide binding (GO:0000166)	1.96	2	TRPM4, DMPK
actin binding (GO:0003779)	3.74	2	MYBPC3, TPM1
purine nucleoside binding (GO:0001883)	2.22	2	TRPM4, DMPK
ribonucleoside binding (GO:0032549)	2.22	2	TRPM4, DMPK
purine nucleotide binding (GO:0017076)	2.19	2	TRPM4, DMPK
protein binding involved in heterotypic cell-cell adhesion (GO:0086080)	7.54	2	DSP, DSG2
ATP binding (GO:0005524)	2.43	2	TRPM4, DMPK
cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication (GO:0086083)	7.95	2	DSP, DSG2
sodium channel activity (GO:0005272)	6.13	2	TRPM4, SCN5A
titin binding (GO:0031432)	7.25	2	MYBPC3, CALM1
protein phosphatase regulator activity (GO:0019888)	5.41	2	CALM1, DMPK
protein kinase activity (GO:0004672)	3.27	2	KCNH2, DMPK
small molecule binding (GO:0036094)	1.89	2	TRPM4, DMPK
protein homodimerization activity (GO:0042803)	3.16	2	KCNH2, CASQ2
structural constituent of muscle (GO:0008307)	6.02	2	MYBPC3, TPM1
cell adhesion molecule binding (GO:0050839)	4.5	2	DSP, DSG2
nitric-oxide synthase binding (GO:0050998)	6.91	2	CALM1, SCN5A
ubiquitin protein ligase binding (GO:0031625)	4.17	2	KCNH2, SCN5A
adenyl nucleotide binding (GO:0030554)	2.4	2	TRPM4, DMPK
carbohydrate derivative binding (GO:0097367)	2.03	2	TRPM4, DMPK
voltage-gated channel activity (GO:0022832)	4.49	2	KCNH2, SCN5A
adenyl ribonucleotide binding (GO:0032559)	2.41	2	TRPM4, DMPK
purine ribonucleotide binding (GO:0032555)	2.2	2	TRPM4, DMPK
protein dimerization activity (GO:0046983)	2.72	2	CASQ2, KCNH2
voltage-gated ion channel activity (GO:0005244)	4.49	2	KCNH2, SCN5A
purine ribonucleoside binding (GO:0032550)	2.22	2	TRPM4, DMPK
ribonucleotide binding (GO:0032553)	2.19	2	TRPM4, DMPK

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein C-terminus binding (GO:0008022)	NEW	4.5	0.026	CALM1, RYR2, SCN5A, DSP, ANK2
structural constituent of cytoskeleton (GO:0005200)	-	5.12	0.011	TPM1, CALM1, DSP, ANK2
cation channel activity (GO:0005261)	-	4.04	0.013	RYR2, CALM1, TRPM4, KCNH2, ANK2, SCN5A
calcium-dependent protein binding (GO:0048306)	-	5.68	0.002	CASQ2, RYR2, CALM1, TPM1
ion channel binding (GO:0044325)	-	5.02	0.0	RYR2, SCN5A, CASQ2, KCNH2, TPM1, TRDN, ANK2, CALM1
ankyrin binding (GO:0030506)	NEW	6.74	0.0	SCN5A, RYR2, CALM1, ANK2
titin binding (GO:0031432)	-	7.25	0.006	MYBPC3, CALM1
ligand-gated ion channel activity (GO:0015276)	-	4.8	0.003	KCNH2, RYR2, CALM1, DMPK, ANK2
structural molecule activity (GO:0005198)	-	3.1	0.007	RYR2, CALM1, LMNA, LAMA4, TPM1, ANK2, MYBPC3, DSP
actin binding (GO:0003779)	-	3.74	0.0	RYR2, CALM1, TPM1, DSP, LMNA, SCN5A, MYBPC3, DMPK
calcium ion binding (GO:0005509)	-	3.17	0.005	TPM1, SCN5A, CALM1, RYR2, TRDN, DSG2, CASQ2, MYBPC3, DSP
channel inhibitor activity (GO:0016248)	NEW	6.13	0.011	KCNH2, RYR2, SCN5A
channel regulator activity (GO:0016247)	NEW	4.88	0.001	CALM1, RYR2, SCN5A, ANK2, KCNH2
passive transmembrane transporter activity (GO:0022803)	-	3.6	0.003	RYR2, SCN5A, TRPM4, KCNH2, ANK2, CALM1, DMPK
metal ion transmembrane transporter activity (GO:0046873)	-	3.71	0.022	RYR2, SCN5A, TRPM4, KCNH2, ANK2, CALM1
voltage-gated cation channel activity (GO:0022843)	NEW	4.83	0.002	CALM1, RYR2, SCN5A, ANK2, KCNH2
nitric-oxide synthase binding (GO:0050998)	-	6.91	0.005	CALM1, SCN5A
ATPase binding (GO:0051117)	NEW	5.41	0.001	CALM1, RYR2, SCN5A, ANK2
ion channel activity (GO:0005216)	-	3.71	0.049	RYR2, SCN5A, TRPM4, KCNH2, ANK2, CALM1, DMPK
cation transmembrane transporter activity (GO:0008324)	-	3.32	0.026	RYR2, CALM1, TRPM4, KCNH2, TPM1, ANK2, SCN5A
actin filament binding (GO:0051015)	NEW	4.93	0.008	MYBPC3, CALM1, DSP, LMNA
protein kinase binding (GO:0019901)	-	3.44	0.003	CALM1, RYR2, SCN5A, DSP, ANK2
kinase binding (GO:0019900)	-	3.32	0.005	CALM1, RYR2, SCN5A, DSP, ANK2
structural constituent of muscle (GO:0008307)	-	6.02	0.009	MYBPC3, TPM1, ANK2
calmodulin binding (GO:0005516)	-	4.55	0.0	RYR2, SCN5A, TRPM4, TPM1, ANK2, CALM1
ion channel inhibitor activity (GO:0008200)	NEW	6.15	0.01	KCNH2, RYR2, SCN5A
binding, bridging (GO:0060090)	-	4.57	0.034	RYR2, CASQ2, TPM1, TRDN, ANK2, CALM1, MYBPC3, DSP
substrate-specific transmembrane transporter activity (GO:0022891)	-	2.9	0.028	RYR2, CALM1, TRPM4, KCNH2, TPM1, ANK2, SCN5A, DMPK
inorganic cation transmembrane transporter activity (GO:0022890)	-	3.49	0.006	RYR2, CALM1, TRPM4, KCNH2, TPM1, ANK2, SCN5A
protein binding, bridging (GO:0030674)	-	4.68	0.0	RYR2, CASQ2, TPM1, TRDN, ANK2, CALM1, MYBPC3, DSP
voltage-gated ion channel activity (GO:0005244)	-	4.49	0.005	CALM1, RYR2, SCN5A, ANK2, KCNH2
cytoskeletal protein binding (GO:0008092)	-	3.02	0.05	TPM1, SCN5A, CASQ2, LMNA, KCNH2, RYR2, DMPK, ANK2, CALM1, MYBPC3, DSP
ion transmembrane transporter activity (GO:0015075)	-	3.04	0.016	RYR2, CALM1, TRPM4, KCNH2, TPM1, ANK2, SCN5A, DMPK
voltage-gated channel activity (GO:0022832)	-	4.49	0.005	CALM1, RYR2, SCN5A, ANK2, KCNH2
transmembrane transporter activity (GO:0022857)	-	2.82	0.049	RYR2, CALM1, TRPM4, KCNH2, TPM1, ANK2, SCN5A, DMPK
channel activity (GO:0015267)	-	3.6	0.003	RYR2, SCN5A, TRPM4, KCNH2, ANK2, CALM1, DMPK
scaffold protein binding (GO:0097110)	-	5.93	0.012	RYR2, SCN5A, DSP
gated channel activity (GO:0022836)	-	3.96	0.02	RYR2, SCN5A, TRPM4, KCNH2, ANK2, CALM1, DMPK
protein binding (GO:0005515)	-	0.46	0.037	RYR2, SCN5A, CASQ2, LMNA, LAMA4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, MYBPC3, TRPM4, DSP
ligand-gated channel activity (GO:0022834)	-	4.8	0.003	CALM1, RYR2, KCNH2, DMPK, ANK2
substrate-specific channel activity (GO:0022838)	-	3.67	0.002	RYR2, CALM1, TRPM4, KCNH2, ANK2, SCN5A, DMPK
inward rectifier potassium channel activity (GO:0005242)	NEW	6.65	0.003	CALM1, KCNH2, ANK2

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	15	RYR2, SCN5A, CASQ2, LMNA, LAMA4, KCNH2, TPM1, DSG2, TRDN, ANK2, CALM1, MYBPC3, DMPK, TRPM4, DSP
regulation of cellular process (GO:0050794)	0.5	15	RYR2, SCN5A, CASQ2, DSG2, LAMA4, KCNH2, TPM1, TRDN, LMNA, DMPK, ANK2, CALM1, MYBPC3, TRPM4, DSP
single-organism cellular process (GO:0044763)	0.65	15	RYR2, SCN5A, CASQ2, LMNA, LAMA4, KCNH2, TPM1, DSG2, TRDN, ANK2, CALM1, MYBPC3, DMPK, TRPM4, DSP
regulation of multicellular organismal process (GO:0051239)	1.87	15	RYR2, SCN5A, CASQ2, DSG2, LAMA4, KCNH2, TPM1, TRDN, LMNA, DMPK, ANK2, CALM1, MYBPC3, TRPM4, DSP
biological regulation (GO:0065007)	0.39	15	RYR2, SCN5A, CASQ2, LMNA, LAMA4, KCNH2, TPM1, TRDN, DSG2, ANK2, CALM1, MYBPC3, DMPK, TRPM4, DSP
regulation of localization (GO:0032879)	1.94	15	RYR2, SCN5A, CASQ2, LMNA, LAMA4, KCNH2, TPM1, DSG2, TRDN, ANK2, CALM1, MYBPC3, DMPK, TRPM4, DSP
regulation of biological process (GO:0050789)	0.45	15	RYR2, SCN5A, CASQ2, LMNA, LAMA4, KCNH2, TPM1, TRDN, DSG2, ANK2, CALM1, MYBPC3, DMPK, TRPM4, DSP
single-organism process (GO:0044699)	0.48	15	RYR2, SCN5A, CASQ2, DSG2, LAMA4, KCNH2, TPM1, TRDN, LMNA, DMPK, ANK2, CALM1, MYBPC3, TRPM4, DSP
regulation of system process (GO:0044057)	3.53	13	RYR2, SCN5A, CASQ2, DSG2, TRPM4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, MYBPC3, DSP
multicellular organismal process (GO:0032501)	1.45	12	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, DSG2, ANK2, CALM1, MYBPC3, DSP
regulation of blood circulation (GO:1903522)	4.05	12	RYR2, SCN5A, CASQ2, DSG2, TRPM4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, DSP
regulation of biological quality (GO:0065008)	1.68	12	TPM1, SCN5A, CASQ2, TRPM4, KCNH2, RYR2, DSG2, TRDN, ANK2, CALM1, DMPK, DSP
regulation of heart contraction (GO:0008016)	4.35	12	RYR2, SCN5A, CASQ2, DSG2, TRPM4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, DSP
response to stimulus (GO:0050896)	1.22	11	TPM1, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, RYR2, DSG2, ANK2, CALM1, DSP
regulation of muscle system process (GO:0090257)	4.51	11	RYR2, SCN5A, CASQ2, TRPM4, TPM1, DSG2, DMPK, ANK2, CALM1, MYBPC3, DSP
regulation of muscle contraction (GO:0006937)	4.75	11	RYR2, SCN5A, CALM1, TRPM4, TPM1, DSG2, DMPK, ANK2, CASQ2, MYBPC3, DSP
developmental process (GO:0032502)	1.36	10	RYR2, CALM1, LMNA, LAMA4, TPM1, DSG2, ANK2, SCN5A, MYBPC3, DSP
regulation of membrane potential (GO:0042391)	3.89	10	RYR2, CASQ2, TRPM4, KCNH2, DSG2, TRDN, ANK2, SCN5A, DMPK, DSP
regulation of cellular component movement (GO:0051270)	3.08	10	RYR2, SCN5A, LMNA, LAMA4, TPM1, DSG2, ANK2, MYBPC3, TRPM4, DSP
regulation of transport (GO:0051049)	2.24	10	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TRDN, ANK2, CALM1, MYBPC3, DMPK
regulation of heart rate (GO:0002027)	5.29	10	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, DSG2, ANK2, CALM1, DSP
regulation of striated muscle contraction (GO:0006942)	5.38	10	RYR2, SCN5A, CALM1, TRPM4, DSG2, DMPK, ANK2, CASQ2, MYBPC3, DSP
positive regulation of biological process (GO:0048518)	1.2	10	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TPM1, TRDN, ANK2, CALM1
localization (GO:0051179)	1.4	10	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TRDN, ANK2, CALM1, DSP
positive regulation of cellular process (GO:0048522)	1.3	10	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TPM1, TRDN, ANK2, CALM1
transport (GO:0006810)	1.51	9	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TRDN, ANK2, CALM1
anatomical structure development (GO:0048856)	1.58	9	TPM1, CALM1, LMNA, LAMA4, RYR2, DSG2, ANK2, SCN5A, DSP
cellular component organization (GO:0016043)	1.24	9	TPM1, CASQ2, DSG2, LAMA4, TRDN, LMNA, DMPK, ANK2, DSP
single-organism developmental process (GO:0044767)	1.49	9	RYR2, CALM1, LMNA, LAMA4, TPM1, ANK2, SCN5A, MYBPC3, DSP
response to chemical (GO:0042221)	1.98	9	RYR2, SCN5A, CALM1, LMNA, KCNH2, TPM1, DSG2, ANK2, CASQ2
establishment of localization (GO:0051234)	1.48	9	RYR2, SCN5A, CALM1, LMNA, TRPM4, KCNH2, TRDN, ANK2, CASQ2
cellular component organization or biogenesis (GO:0071840)	1.22	9	TPM1, CASQ2, DSG2, LAMA4, TRDN, LMNA, DMPK, ANK2, DSP
system process (GO:0003008)	2.3	9	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, CALM1, MYBPC3
single organism signaling (GO:0044700)	3.25	8	RYR2, CASQ2, TRPM4, KCNH2, DSG2, ANK2, SCN5A, DSP
single-multicellular organism process (GO:0044707)	1.78	8	TPM1, SCN5A, TRPM4, KCNH2, RYR2, DSG2, ANK2, DSP
regulation of cellular localization (GO:0060341)	3.03	8	RYR2, CASQ2, LMNA, TRPM4, TRDN, ANK2, CALM1, MYBPC3
muscle contraction (GO:0006936)	4.37	8	RYR2, SCN5A, CASQ2, KCNH2, TPM1, TRDN, CALM1, MYBPC3
ion transport (GO:0006811)	2.66	8	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TRDN, ANK2, CALM1
regulation of actin filament-based process (GO:0032970)	3.97	8	TPM1, SCN5A, TRPM4, RYR2, DSG2, ANK2, MYBPC3, DSP
regulation of metal ion transport (GO:0010959)	3.94	8	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, DMPK
muscle system process (GO:0003012)	4.18	8	RYR2, SCN5A, CASQ2, KCNH2, TPM1, TRDN, CALM1, MYBPC3
signaling (GO:0023052)	3.25	8	RYR2, CASQ2, TRPM4, KCNH2, DSG2, ANK2, SCN5A, DSP
regulation of ion transport (GO:0043269)	3.4	8	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, DMPK
regulation of signaling (GO:0023051)	1.72	8	RYR2, CASQ2, LMNA, TRPM4, TRDN, ANK2, CALM1, DMPK
negative regulation of biological process (GO:0048519)	1.33	8	RYR2, CALM1, TRPM4, KCNH2, TPM1, TRDN, LMNA, CASQ2
regulation of molecular function (GO:0065009)	1.78	8	RYR2, CALM1, TPM1, TRDN, ANK2, CASQ2, MYBPC3, DMPK
regulation of cell communication (GO:0010646)	1.73	8	RYR2, CASQ2, LMNA, TRPM4, TRDN, ANK2, CALM1, DMPK
regulation of cardiac muscle contraction (GO:0055117)	5.57	8	RYR2, SCN5A, CASQ2, TRPM4, DSG2, ANK2, CALM1, DSP
negative regulation of cellular process (GO:0048523)	1.41	8	RYR2, CASQ2, TRPM4, KCNH2, TPM1, TRDN, LMNA, CALM1
regulation of actin filament-based movement (GO:1903115)	6.33	7	RYR2, SCN5A, TRPM4, DSG2, ANK2, MYBPC3, DSP
regulation of cardiac conduction (GO:1903779)	5.57	7	RYR2, CASQ2, TRPM4, TRDN, ANK2, CALM1, DMPK
positive regulation of transport (GO:0051050)	2.9	7	RYR2, CALM1, TRPM4, KCNH2, TRDN, ANK2, SCN5A
regulation of cation transmembrane transport (GO:1904062)	4.4	7	RYR2, SCN5A, CALM1, KCNH2, TRDN, ANK2, CASQ2
regulation of homeostatic process (GO:0032844)	3.65	7	RYR2, SCN5A, CALM1, TRPM4, TRDN, ANK2, CASQ2
ion transmembrane transport (GO:0034220)	3.08	7	RYR2, CALM1, KCNH2, TRPM4, CASQ2, TRDN, SCN5A
regulation of ion homeostasis (GO:2000021)	4.44	7	RYR2, SCN5A, CASQ2, TRPM4, TRDN, ANK2, CALM1
signal transduction (GO:0007165)	1.28	7	RYR2, CASQ2, LMNA, KCNH2, ANK2, CALM1, DMPK
regulation of ion transmembrane transport (GO:0034765)	3.77	7	CALM1, RYR2, CASQ2, KCNH2, TRDN, ANK2, SCN5A
transmembrane transport (GO:0055085)	2.72	7	CALM1, RYR2, CASQ2, TRPM4, KCNH2, TRDN, SCN5A
regulation of transmembrane transport (GO:0034762)	3.74	7	RYR2, SCN5A, CALM1, KCNH2, TRDN, ANK2, CASQ2
multicellular organismal signaling (GO:0035637)	5.36	6	SCN5A, TRPM4, KCNH2, DSG2, ANK2, DSP
ion homeostasis (GO:0050801)	3.42	6	RYR2, TRPM4, KCNH2, TRDN, ANK2, DMPK
regulation of response to stimulus (GO:0048583)	1.54	6	CALM1, TRPM4, TRDN, LMNA, CASQ2, DMPK
homeostatic process (GO:0042592)	2.61	6	RYR2, TRPM4, KCNH2, TRDN, ANK2, DMPK
cellular response to chemical stimulus (GO:0070887)	2.57	6	RYR2, SCN5A, KCNH2, TPM1, LMNA, CASQ2
inorganic ion homeostasis (GO:0098771)	3.43	6	RYR2, TRPM4, KCNH2, TRDN, ANK2, DMPK
intracellular signal transduction (GO:0035556)	2.39	6	RYR2, CALM1, KCNH2, ANK2, CASQ2, DMPK
cardiac muscle contraction (GO:0060048)	5.88	6	RYR2, CASQ2, KCNH2, TPM1, SCN5A, MYBPC3
regulation of cardiac muscle cell contraction (GO:0086004)	6.51	6	RYR2, SCN5A, TRPM4, DSG2, ANK2, DSP
cellular response to stimulus (GO:0051716)	1.97	6	RYR2, CASQ2, KCNH2, TPM1, LMNA, SCN5A
regulation of signal transduction (GO:0009966)	1.84	6	CASQ2, TRPM4, TRDN, LMNA, CALM1, DMPK
positive regulation of multicellular organismal process (GO:0051240)	2.49	6	RYR2, SCN5A, TRPM4, TPM1, TRDN, LMNA
regulation of action potential (GO:0098900)	6.07	6	RYR2, SCN5A, TRPM4, DSG2, ANK2, DSP
positive regulation of molecular function (GO:0044093)	2.23	6	RYR2, CALM1, TPM1, TRDN, ANK2, MYBPC3
cardiac conduction (GO:0061337)	5.54	6	SCN5A, TRPM4, KCNH2, DSG2, ANK2, DSP
cation transport (GO:0006812)	3.11	6	RYR2, SCN5A, TRPM4, KCNH2, TRDN, ANK2
positive regulation of ion transport (GO:0043270)	4.36	6	RYR2, CALM1, KCNH2, TRDN, ANK2, SCN5A
single-organism transport (GO:0044765)	2.18	6	RYR2, CALM1, LMNA, KCNH2, TRDN, ANK2
metal ion transport (GO:0030001)	3.36	6	RYR2, SCN5A, TRPM4, KCNH2, TRDN, ANK2
metal ion homeostasis (GO:0055065)	3.61	6	RYR2, TRPM4, KCNH2, TRDN, ANK2, DMPK
cation homeostasis (GO:0055080)	3.46	6	RYR2, TRPM4, KCNH2, TRDN, ANK2, DMPK
single-organism localization (GO:1902578)	2.09	6	RYR2, CALM1, LMNA, KCNH2, TRDN, ANK2
striated muscle contraction (GO:0006941)	5.37	6	RYR2, CASQ2, KCNH2, TPM1, SCN5A, MYBPC3
chemical homeostasis (GO:0048878)	2.97	6	RYR2, TRPM4, KCNH2, TRDN, ANK2, DMPK
cellular cation homeostasis (GO:0030003)	3.6	5	RYR2, TRPM4, DMPK, ANK2, TRDN
regulation of ion transmembrane transporter activity (GO:0032412)	4.55	5	CALM1, RYR2, CASQ2, ANK2, TRDN
regulation of sequestering of calcium ion (GO:0051282)	5.07	5	CASQ2, RYR2, CALM1, ANK2, TRDN
positive regulation of homeostatic process (GO:0032846)	4.38	5	CASQ2, TRPM4, CALM1, RYR2, TRDN
regulation of calcium ion transmembrane transport (GO:1903169)	4.98	5	CASQ2, RYR2, CALM1, ANK2, TRDN
calcium ion homeostasis (GO:0055074)	3.97	5	RYR2, TRPM4, DMPK, ANK2, TRDN
second-messenger-mediated signaling (GO:0019932)	4.65	5	CALM1, RYR2, CASQ2, DMPK, ANK2
positive regulation of transmembrane transport (GO:0034764)	4.99	5	CALM1, RYR2, KCNH2, ANK2, TRDN
positive regulation of ion transmembrane transport (GO:0034767)	5.05	5	KCNH2, RYR2, CALM1, ANK2, TRDN
divalent inorganic cation homeostasis (GO:0072507)	3.9	5	RYR2, TRPM4, DMPK, ANK2, TRDN
cellular protein metabolic process (GO:0044267)	1.63	5	KCNH2, TRPM4, CALM1, DSP, DMPK
anatomical structure morphogenesis (GO:0009653)	2.53	5	RYR2, SCN5A, MYBPC3, DSP, TPM1
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	5	RYR2, TRPM4, DMPK, ANK2, TRDN
cellular macromolecule metabolic process (GO:0044260)	0.93	5	CALM1, TRPM4, KCNH2, DSP, DMPK
organic substance metabolic process (GO:0071704)	0.63	5	KCNH2, TRPM4, CALM1, DSP, DMPK
single-organism organelle organization (GO:1902589)	2.68	5	DSP, TPM1, CASQ2, LMNA, TRDN
regulation of calcium ion import (GO:0090279)	5.08	5	CALM1, RYR2, CASQ2, ANK2, TRDN
cellular metal ion homeostasis (GO:0006875)	3.75	5	RYR2, TRPM4, DMPK, ANK2, TRDN
regulation of transporter activity (GO:0032409)	4.45	5	CASQ2, RYR2, CALM1, ANK2, TRDN
inorganic cation transmembrane transport (GO:0098662)	3.55	5	KCNH2, TRPM4, SCN5A, RYR2, TRDN
regulation of cardiac muscle cell action potential (GO:0098901)	6.78	5	RYR2, DSP, TRPM4, ANK2, DSG2
regulation of calcium ion transport into cytosol (GO:0010522)	5.23	5	CALM1, RYR2, CASQ2, ANK2, TRDN
cellular homeostasis (GO:0019725)	3.23	5	RYR2, TRPM4, DMPK, ANK2, TRDN
calcium-mediated signaling (GO:0019722)	5.24	5	CALM1, RYR2, CASQ2, DMPK, ANK2
regulation of developmental process (GO:0050793)	2.1	5	TRPM4, DMPK, LAMA4, LMNA, TPM1
cellular calcium ion homeostasis (GO:0006874)	4.01	5	RYR2, TRPM4, DMPK, ANK2, TRDN
regulation of catalytic activity (GO:0050790)	1.97	5	RYR2, DMPK, CALM1, MYBPC3, TPM1
cellular ion homeostasis (GO:0006873)	3.57	5	RYR2, TRPM4, DMPK, ANK2, TRDN
macromolecule modification (GO:0043412)	1.73	5	KCNH2, TRPM4, CALM1, DSP, DMPK
protein modification process (GO:0036211)	1.79	5	KCNH2, TRPM4, CALM1, DMPK, DSP
cellular protein modification process (GO:0006464)	1.79	5	KCNH2, TRPM4, CALM1, DMPK, DSP
metabolic process (GO:0008152)	0.58	5	CALM1, TRPM4, KCNH2, DSP, DMPK
cellular chemical homeostasis (GO:0055082)	3.4	5	RYR2, TRPM4, DMPK, ANK2, TRDN
response to organic substance (GO:0010033)	2.2	5	CALM1, RYR2, CASQ2, ANK2, DSG2
organelle organization (GO:0006996)	2.02	5	DSP, TPM1, CASQ2, LMNA, TRDN
primary metabolic process (GO:0044238)	0.69	5	CALM1, TRPM4, KCNH2, DMPK, DSP
regulation of calcium ion transmembrane transporter activity (GO:1901019)	5.49	5	CALM1, RYR2, CASQ2, ANK2, TRDN
cytoskeleton organization (GO:0007010)	3.22	5	DSP, TPM1, CASQ2, LMNA, TRDN
protein metabolic process (GO:0019538)	1.45	5	KCNH2, TRPM4, CALM1, DMPK, DSP
regulation of transmembrane transporter activity (GO:0022898)	4.52	5	CALM1, RYR2, CASQ2, ANK2, TRDN
regulation of release of sequestered calcium ion into cytosol (GO:0051279)	5.44	5	CALM1, RYR2, CASQ2, ANK2, TRDN
regulation of calcium ion transport (GO:0051924)	4.38	5	CASQ2, RYR2, CALM1, ANK2, TRDN
inorganic ion transmembrane transport (GO:0098660)	3.38	5	KCNH2, RYR2, SCN5A, TRPM4, TRDN
cellular metabolic process (GO:0044237)	0.69	5	KCNH2, TRPM4, CALM1, DMPK, DSP
macromolecule metabolic process (GO:0043170)	0.83	5	KCNH2, TRPM4, CALM1, DSP, DMPK
regulation of heart rate by cardiac conduction (GO:0086091)	6.33	5	DSP, KCNH2, SCN5A, ANK2, DSG2
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	6.59	5	CASQ2, RYR2, CALM1, ANK2, TRDN
cation transmembrane transport (GO:0098655)	3.43	5	SCN5A, TRPM4, KCNH2, RYR2, TRDN
positive regulation of cation transmembrane transport (GO:1904064)	5.17	5	KCNH2, RYR2, CALM1, ANK2, TRDN
positive regulation of ion transmembrane transporter activity (GO:0032414)	5.55	4	RYR2, CALM1, ANK2, TRDN
positive regulation of transporter activity (GO:0032411)	5.44	4	RYR2, CALM1, ANK2, TRDN
ventricular cardiac muscle tissue morphogenesis (GO:0055010)	6.07	4	DSP, RYR2, MYBPC3, TPM1
membrane organization (GO:0061024)	3.04	4	DMPK, ANK2, LMNA, TRDN
negative regulation of response to stimulus (GO:0048585)	2.52	4	CASQ2, CALM1, LMNA, TRDN
regulation of membrane repolarization (GO:0060306)	6.4	4	CASQ2, SCN5A, ANK2, KCNH2
negative regulation of homeostatic process (GO:0032845)	4.91	4	CASQ2, RYR2, CALM1, TRDN
negative regulation of signaling (GO:0023057)	2.65	4	CASQ2, CALM1, LMNA, TRDN
negative regulation of cell communication (GO:0010648)	2.66	4	CALM1, CASQ2, LMNA, TRDN
cell communication (GO:0007154)	3.04	4	SCN5A, RYR2, CASQ2, ANK2
action potential (GO:0001508)	5.42	4	KCNH2, RYR2, SCN5A, ANK2
negative regulation of ion transmembrane transport (GO:0034766)	5.47	4	KCNH2, CASQ2, CALM1, TRDN
cell communication involved in cardiac conduction (GO:0086065)	6.73	4	SCN5A, RYR2, CASQ2, ANK2
response to organic cyclic compound (GO:0014070)	3.07	4	CASQ2, RYR2, CALM1, DSG2
negative regulation of transmembrane transport (GO:0034763)	5.38	4	CASQ2, CALM1, TRDN, KCNH2
response to endogenous stimulus (GO:0009719)	2.79	4	CASQ2, RYR2, CALM1, DSG2
ventricular cardiac muscle cell action potential (GO:0086005)	7.02	4	SCN5A, RYR2, KCNH2, ANK2
cardiac muscle cell action potential involved in contraction (GO:0086002)	6.47	4	KCNH2, RYR2, SCN5A, ANK2
cardiac muscle cell action potential (GO:0086001)	6.33	4	KCNH2, RYR2, SCN5A, ANK2
positive regulation of hydrolase activity (GO:0051345)	2.91	4	RYR2, CALM1, MYBPC3, TPM1
positive regulation of blood circulation (GO:1903524)	5.16	4	TRPM4, SCN5A, RYR2, TPM1
positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	6.36	4	RYR2, CALM1, ANK2, TRDN
positive regulation of catalytic activity (GO:0043085)	2.4	4	RYR2, CALM1, MYBPC3, TPM1
tissue morphogenesis (GO:0048729)	3.87	4	DSP, RYR2, MYBPC3, TPM1
positive regulation of calcium ion transmembrane transport (GO:1904427)	5.69	4	RYR2, CALM1, ANK2, TRDN
biological adhesion (GO:0022610)	2.81	4	DSP, LAMA4, MYBPC3, DSG2
positive regulation of sequestering of calcium ion (GO:0051284)	7.09	4	CASQ2, RYR2, CALM1, TRDN
positive regulation of heart rate (GO:0010460)	6.59	4	TRPM4, SCN5A, RYR2, TPM1
regulation of hydrolase activity (GO:0051336)	2.53	4	RYR2, CALM1, MYBPC3, TPM1
negative regulation of transport (GO:0051051)	3.6	4	CASQ2, CALM1, TRDN, KCNH2
cardiac muscle tissue morphogenesis (GO:0055008)	5.8	4	RYR2, MYBPC3, DSP, TPM1
calcium ion transport (GO:0006816)	4.33	4	RYR2, TRPM4, ANK2, TRDN
response to calcium ion (GO:0051592)	4.98	4	CASQ2, RYR2, SCN5A, CALM1
negative regulation of ion transport (GO:0043271)	4.94	4	CALM1, KCNH2, CASQ2, TRDN
response to stress (GO:0006950)	1.8	4	RYR2, DSP, LMNA, TPM1
single-organism membrane organization (GO:0044802)	3.19	4	DMPK, ANK2, LMNA, TRDN
response to metal ion (GO:0010038)	3.91	4	CASQ2, RYR2, SCN5A, CALM1
establishment of localization in cell (GO:0051649)	2.47	4	RYR2, ANK2, TRDN, LMNA
cell adhesion (GO:0007155)	2.82	4	DSP, LAMA4, MYBPC3, DSG2
divalent metal ion transport (GO:0070838)	4.15	4	RYR2, TRPM4, ANK2, TRDN
response to inorganic substance (GO:0010035)	3.56	4	CALM1, RYR2, SCN5A, CASQ2
response to oxygen-containing compound (GO:1901700)	2.57	4	RYR2, CALM1, TPM1, DSG2
divalent inorganic cation transport (GO:0072511)	4.13	4	RYR2, TRPM4, ANK2, TRDN
negative regulation of signal transduction (GO:0009968)	2.75	4	CALM1, CASQ2, LMNA, TRDN
positive regulation of calcium ion transport (GO:0051928)	5.06	4	RYR2, CALM1, ANK2, TRDN
negative regulation of cation transmembrane transport (GO:1904063)	5.65	4	CASQ2, CALM1, TRDN, KCNH2
positive regulation of heart contraction (GO:0045823)	6.15	4	TRPM4, SCN5A, RYR2, TPM1
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	6.68	4	CALM1, RYR2, CASQ2, ANK2
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881)	6.9	4	CALM1, RYR2, CASQ2, ANK2
regulation of cation channel activity (GO:2001257)	5.27	4	CASQ2, CALM1, ANK2, TRDN
muscle tissue morphogenesis (GO:0060415)	5.62	4	DSP, RYR2, MYBPC3, TPM1
regulation of ventricular cardiac muscle cell action potential (GO:0098911)	7.33	3	RYR2, DSP, DSG2
protein localization (GO:0008104)	2.36	3	DSP, LMNA, ANK2
negative regulation of transporter activity (GO:0032410)	5.59	3	CASQ2, CALM1, TRDN
regulation of metabolic process (GO:0019222)	1.02	3	RYR2, CALM1, ANK2
negative regulation of ion transmembrane transporter activity (GO:0032413)	5.74	3	CASQ2, CALM1, TRDN
phosphorylation (GO:0016310)	2.63	3	CALM1, KCNH2, DMPK
cell junction organization (GO:0034330)	4.51	3	DSP, ANK2, DSG2
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	6.84	3	KCNH2, SCN5A, ANK2
negative regulation of calcium-mediated signaling (GO:0050849)	6.9	3	CASQ2, CALM1, TRDN
regulation of calcium-mediated signaling (GO:0050848)	5.41	3	CASQ2, CALM1, TRDN
positive regulation of signaling (GO:0023056)	2.41	3	TRPM4, CALM1, TRDN
regulation of potassium ion transport (GO:0043266)	5.31	3	KCNH2, CASQ2, ANK2
membrane depolarization (GO:0051899)	5.62	3	KCNH2, SCN5A, ANK2
regulation of cell migration (GO:0030334)	3.23	3	LAMA4, TPM1, LMNA
regulation of cell communication by electrical coupling (GO:0010649)	7.33	3	CALM1, CASQ2, TRDN
detection of chemical stimulus (GO:0009593)	3.49	3	CASQ2, RYR2, CALM1
positive regulation of cell communication (GO:0010647)	2.41	3	TRPM4, CALM1, TRDN
regulation of intracellular signal transduction (GO:1902531)	2.31	3	CASQ2, CALM1, TRDN
negative regulation of calcium ion import (GO:0090281)	6.59	3	CASQ2, CALM1, TRDN
negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	6.59	3	CALM1, CASQ2, TRDN
positive regulation of signal transduction (GO:0009967)	2.5	3	TRPM4, CALM1, TRDN
movement of cell or subcellular component (GO:0006928)	2.61	3	TRPM4, MYBPC3, TPM1
sarcoplasmic reticulum calcium ion transport (GO:0070296)	7.33	3	RYR2, ANK2, TRDN
cellular developmental process (GO:0048869)	1.82	3	LAMA4, DSP, LMNA
negative regulation of molecular function (GO:0044092)	2.74	3	CALM1, CASQ2, TRDN
regulation of cell motility (GO:2000145)	3.16	3	LAMA4, TPM1, LMNA
macromolecule localization (GO:0033036)	2.34	3	DSP, LMNA, ANK2
regulation of receptor activity (GO:0010469)	4.98	3	CALM1, CASQ2, TRDN
monovalent inorganic cation transport (GO:0015672)	3.74	3	KCNH2, TRPM4, SCN5A
negative regulation of calcium ion transport into cytosol (GO:0010523)	6.9	3	CASQ2, CALM1, TRDN
regulation of cell proliferation (GO:0042127)	2.41	3	TRPM4, SCN5A, TPM1
negative regulation of receptor activity (GO:2000272)	6.4	3	CASQ2, CALM1, TRDN
protein phosphorylation (GO:0006468)	2.89	3	KCNH2, CALM1, DMPK
positive regulation of response to stimulus (GO:0048584)	2.18	3	TRPM4, CALM1, TRDN
negative regulation of calcium ion transmembrane transport (GO:1903170)	6.43	3	CALM1, CASQ2, TRDN
actin filament-based process (GO:0030029)	3.94	3	MYBPC3, CASQ2, TPM1
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	RYR2, CALM1, ANK2
positive regulation of ATPase activity (GO:0032781)	5.99	3	RYR2, MYBPC3, TPM1
positive regulation of cation channel activity (GO:2001259)	6.17	3	CALM1, ANK2, TRDN
establishment of protein localization (GO:0045184)	2.53	3	RYR2, ANK2, LMNA
negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	7.43	3	CASQ2, CALM1, TRDN
regulation of cell differentiation (GO:0045595)	2.42	3	TRPM4, DMPK, LMNA
regulation of ATPase activity (GO:0043462)	5.59	3	RYR2, MYBPC3, TPM1
regulation of potassium ion transmembrane transport (GO:1901379)	5.62	3	KCNH2, CASQ2, ANK2
negative regulation of release of sequestered calcium ion into cytosol (GO:0051280)	7.16	3	CALM1, CASQ2, TRDN
cell-cell junction organization (GO:0045216)	4.66	3	DSP, ANK2, DSG2
negative regulation of intracellular signal transduction (GO:1902532)	3.63	3	CASQ2, CALM1, TRDN
membrane depolarization during action potential (GO:0086010)	6.07	3	KCNH2, SCN5A, ANK2
regulation of cellular component organization (GO:0051128)	2.01	3	TPM1, DMPK, LMNA
regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	6.51	3	CALM1, CASQ2, TRDN
regulation of locomotion (GO:0040012)	3.12	3	LAMA4, TPM1, LMNA
detection of stimulus (GO:0051606)	3.22	3	CALM1, RYR2, CASQ2
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	3	TRPM4, RYR2, TRDN
negative regulation of calcium ion transport (GO:0051926)	5.84	3	CALM1, CASQ2, TRDN
response to organonitrogen compound (GO:0010243)	3.2	3	CASQ2, RYR2, CALM1
calcium ion transmembrane transport (GO:0070588)	4.67	3	TRPM4, RYR2, TRDN
positive regulation of cytosolic calcium ion concentration (GO:0007204)	4.56	3	TRPM4, RYR2, TRDN
detection of calcium ion (GO:0005513)	7.24	3	CALM1, RYR2, CASQ2
phosphate-containing compound metabolic process (GO:0006796)	2.16	3	KCNH2, CALM1, DMPK
regulation of cardiac muscle cell membrane repolarization (GO:0099623)	6.68	3	KCNH2, SCN5A, ANK2
regulation of multicellular organismal development (GO:2000026)	2.31	3	TRPM4, LAMA4, LMNA
regulation of atrial cardiac muscle cell action potential (GO:0098910)	8.12	3	TRPM4, RYR2, ANK2
negative regulation of cation channel activity (GO:2001258)	6.26	3	CALM1, CASQ2, TRDN
phosphorus metabolic process (GO:0006793)	2.15	3	KCNH2, CALM1, DMPK
response to nitrogen compound (GO:1901698)	3.12	3	CALM1, RYR2, CASQ2
heterotypic cell-cell adhesion (GO:0034113)	6.43	2	DSP, DSG2
regulation of primary metabolic process (GO:0080090)	1.08	2	RYR2, CALM1
negative regulation of sequestering of calcium ion (GO:0051283)	6.04	2	RYR2, TRDN
positive regulation of release of sequestered calcium ion into cytosol (GO:0051281)	6.12	2	CALM1, TRDN
cardiac muscle cell-cardiac muscle cell adhesion (GO:0086042)	7.94	2	DSP, DSG2
circulatory system process (GO:0003013)	4.38	2	TRPM4, TRDN
cell surface receptor signaling pathway (GO:0007166)	2.09	2	RYR2, CALM1
membrane depolarization during cardiac muscle cell action potential (GO:0086012)	7.09	2	SCN5A, ANK2
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114)	3.79	2	RYR2, CALM1
signal transduction by protein phosphorylation (GO:0023014)	3.79	2	KCNH2, CALM1
single-organism metabolic process (GO:0044710)	1.63	2	KCNH2, CALM1
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	2	CALM1, ANK2
cellular macromolecule localization (GO:0070727)	3.1	2	LMNA, ANK2
cellular response to organic substance (GO:0071310)	2.78	2	RYR2, CASQ2
response to mechanical stimulus (GO:0009612)	4.41	2	RYR2, LMNA
release of sequestered calcium ion into cytosol (GO:0051209)	6.04	2	RYR2, TRDN
regulation of SA node cell action potential (GO:0098907)	9.04	2	RYR2, ANK2
regulation of osteoblast differentiation (GO:0045667)	4.99	2	TRPM4, LMNA
animal organ development (GO:0048513)	2.53	2	DSP, LMNA
positive regulation of calcium ion transport into cytosol (GO:0010524)	5.82	2	CALM1, TRDN
positive regulation of cardiac conduction (GO:1903781)	8.63	2	TRPM4, TRDN
muscle filament sliding (GO:0030049)	6.09	2	MYBPC3, TPM1
actin filament-based movement (GO:0030048)	5.54	2	MYBPC3, TPM1
positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	7.78	2	CALM1, TRDN
calcium ion import into cytosol (GO:1902656)	5.99	2	RYR2, TRDN
desmosome organization (GO:0002934)	7.53	2	DSP, DSG2
single organism reproductive process (GO:0044702)	2.73	2	LMNA, DSG2
vesicle-mediated transport (GO:0016192)	2.72	2	CALM1, ANK2
response to external stimulus (GO:0009605)	2.55	2	RYR2, LMNA
Wnt signaling pathway (GO:0016055)	3.88	2	RYR2, CALM1
regulation of gene expression (GO:0010468)	1.37	2	RYR2, ANK2
calcium ion import (GO:0070509)	5.57	2	RYR2, TRDN
cellular response to stress (GO:0033554)	2.51	2	TPM1, LMNA
response to hormone (GO:0009725)	3.33	2	CALM1, DSG2
cellular component assembly (GO:0022607)	2.14	2	CASQ2, ANK2
positive regulation of metabolic process (GO:0009893)	1.74	2	CALM1, ANK2
microtubule cytoskeleton organization (GO:0000226)	4.13	2	LMNA, TRDN
intracellular protein transport (GO:0006886)	3.2	2	LMNA, ANK2
Purkinje myocyte to ventricular cardiac muscle cell signaling (GO:0086029)	9.04	2	RYR2, CASQ2
regulation of immune system process (GO:0002682)	2.5	2	TRPM4, CALM1
cellular protein localization (GO:0034613)	3.11	2	LMNA, ANK2
calcium ion transmembrane import into cytosol (GO:0097553)	5.99	2	RYR2, TRDN
positive regulation of receptor activity (GO:2000273)	5.97	2	CALM1, TRDN
organ morphogenesis (GO:0009887)	3.55	2	MYBPC3, SCN5A
single organism cell adhesion (GO:0098602)	3.63	2	DSP, DSG2
cell-cell adhesion (GO:0098609)	3.34	2	DSP, DSG2
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0014808)	7.78	2	RYR2, TRDN
regulation of biosynthetic process (GO:0009889)	1.37	2	RYR2, CALM1
tissue development (GO:0009888)	3.27	2	DSP, DSG2
response to caffeine (GO:0031000)	6.84	2	RYR2, CASQ2
sodium ion transport (GO:0006814)	4.75	2	TRPM4, SCN5A
programmed cell death (GO:0012501)	3.1	2	RYR2, DMPK
wound healing (GO:0042060)	5.13	2	TPM1, DSP
positive regulation of intracellular signal transduction (GO:1902533)	2.95	2	CALM1, TRDN
regulation of ossification (GO:0030278)	4.53	2	TRPM4, LMNA
regulation of heart rate by chemical signal (GO:0003062)	8.12	2	TPM1, KCNH2
intracellular transport (GO:0046907)	2.67	2	ANK2, LMNA
response to decreased oxygen levels (GO:0036293)	4.09	2	RYR2, LMNA
cellular response to nitrogen compound (GO:1901699)	3.79	2	RYR2, CASQ2
regulation of organelle organization (GO:0033043)	2.72	2	TPM1, LMNA
regulation of cell adhesion (GO:0030155)	3.27	2	LAMA4, TPM1
cell differentiation (GO:0030154)	2.14	2	LAMA4, DSP
response to wounding (GO:0009611)	4.39	2	TPM1, DSP
peptidyl-amino acid modification (GO:0018193)	2.98	2	TRPM4, DMPK
response to purine-containing compound (GO:0014074)	4.67	2	RYR2, CASQ2
response to hypoxia (GO:0001666)	4.13	2	RYR2, LMNA
regulation of protein localization (GO:0032880)	2.88	2	TRPM4, LMNA
positive regulation of calcium ion import (GO:0090280)	5.72	2	CALM1, TRDN
membrane depolarization during SA node cell action potential (GO:0086046)	8.34	2	SCN5A, ANK2
negative regulation of multicellular organismal process (GO:0051241)	2.84	2	TRPM4, LMNA
actin-myosin filament sliding (GO:0033275)	6.09	2	MYBPC3, TPM1
cellular localization (GO:0051641)	2.32	2	LMNA, ANK2
regulation of sodium ion transport (GO:0002028)	5.4	2	SCN5A, DMPK
positive regulation of cell proliferation (GO:0008284)	3.01	2	TRPM4, SCN5A
multicellular organismal reproductive process (GO:0048609)	3.35	2	LMNA, DSG2
response to abiotic stimulus (GO:0009628)	2.8	2	RYR2, LMNA
establishment of protein localization to organelle (GO:0072594)	3.92	2	RYR2, LMNA
positive regulation of cell differentiation (GO:0045597)	3.01	2	TRPM4, LMNA
cell-cell signaling involved in cardiac conduction (GO:0086019)	8.12	2	RYR2, CASQ2
sarcomere organization (GO:0045214)	6.4	2	TPM1, CASQ2
mitotic cell cycle process (GO:1903047)	3.12	2	CALM1, LMNA
response to alkaloid (GO:0043279)	4.83	2	RYR2, CASQ2
SA node cell action potential (GO:0086015)	7.94	2	SCN5A, ANK2
negative regulation of developmental process (GO:0051093)	3.17	2	TRPM4, LMNA
regulation of immune response (GO:0050776)	2.98	2	TRPM4, CALM1
positive regulation of developmental process (GO:0051094)	2.77	2	TRPM4, LMNA
cellular response to organic cyclic compound (GO:0071407)	3.93	2	RYR2, CASQ2
regulation of membrane depolarization (GO:0003254)	6.04	2	TRPM4, SCN5A
protein localization to organelle (GO:0033365)	3.57	2	LMNA, ANK2
response to steroid hormone (GO:0048545)	4.24	2	CALM1, DSG2
cellular response to endogenous stimulus (GO:0071495)	3.33	2	RYR2, CASQ2
single organismal cell-cell adhesion (GO:0016337)	3.69	2	DSP, DSG2
actomyosin structure organization (GO:0031032)	5.4	2	TPM1, CASQ2
regulation of cellular biosynthetic process (GO:0031326)	1.38	2	RYR2, CALM1
calcium ion transport from endoplasmic reticulum to cytosol (GO:1903514)	7.78	2	RYR2, TRDN
regulation of cellular metabolic process (GO:0031323)	1.07	2	RYR2, CALM1
actin cytoskeleton organization (GO:0030036)	4.1	2	TPM1, CASQ2
negative regulation of potassium ion transport (GO:0043267)	6.26	2	KCNH2, CASQ2
cell cycle process (GO:0022402)	2.75	2	CALM1, LMNA
regulation of potassium ion transmembrane transporter activity (GO:1901016)	6.02	2	CASQ2, ANK2
Purkinje myocyte to ventricular cardiac muscle cell communication (GO:0086068)	9.04	2	RYR2, CASQ2
cell death (GO:0008219)	3.05	2	RYR2, DMPK
multicellular organism development (GO:0007275)	2.54	2	RYR2, TPM1
positive regulation of potassium ion transport (GO:0043268)	6.09	2	KCNH2, ANK2
positive regulation of action potential (GO:0045760)	7.33	2	TRPM4, SCN5A
response to lipid (GO:0033993)	3.11	2	CALM1, DSG2
cellular response to organonitrogen compound (GO:0071417)	3.87	2	RYR2, CASQ2
cellular response to alkaloid (GO:0071312)	6.2	2	RYR2, CASQ2
cellular response to caffeine (GO:0071313)	7.65	2	RYR2, CASQ2
sodium ion transmembrane transport (GO:0035725)	5.23	2	TRPM4, SCN5A
regulation of adipose tissue development (GO:1904177)	8.63	2	TRPM4, LMNA
organic substance transport (GO:0071702)	2.15	2	ANK2, LMNA
negative regulation of potassium ion transmembrane transport (GO:1901380)	6.68	2	CASQ2, KCNH2
positive regulation of potassium ion transmembrane transport (GO:1901381)	6.43	2	KCNH2, ANK2
regulation of cell communication by electrical coupling involved in cardiac conduction (GO:1901844)	7.78	2	CALM1, TRDN
positive regulation of calcium-mediated signaling (GO:0050850)	6.12	2	CALM1, TRDN
cytosolic calcium ion transport (GO:0060401)	5.74	2	RYR2, TRDN
calcium ion transport into cytosol (GO:0060402)	5.78	2	RYR2, TRDN
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	2	RYR2, CALM1
homotypic cell-cell adhesion (GO:0034109)	5.76	2	DSP, DSG2
apoptotic process (GO:0006915)	3.14	2	RYR2, DMPK
reproductive process (GO:0022414)	2.55	2	LMNA, DSG2
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	2	RYR2, CALM1
cell-cell signaling (GO:0007267)	3.35	2	RYR2, CASQ2
bundle of His cell-Purkinje myocyte adhesion involved in cell communication (GO:0086073)	7.94	2	DSP, DSG2
response to oxygen levels (GO:0070482)	4.02	2	RYR2, LMNA
cellular response to oxygen-containing compound (GO:1901701)	3.22	2	RYR2, TPM1
microtubule-based process (GO:0007017)	3.54	2	LMNA, TRDN
nuclear envelope organization (GO:0006998)	5.45	2	DMPK, LMNA
cellular response to purine-containing compound (GO:0071415)	7.53	2	RYR2, CASQ2
response to ketone (GO:1901654)	4.53	2	CALM1, DSG2
protein transport (GO:0015031)	2.62	2	ANK2, LMNA
single-organism intracellular transport (GO:1902582)	3.59	2	ANK2, LMNA
actin-mediated cell contraction (GO:0070252)	5.88	2	MYBPC3, TPM1
single-organism cellular localization (GO:1902580)	3.16	2	LMNA, ANK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of transport (GO:0051049)	-	2.24	0.0	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, MYBPC3, DMPK
regulation of intracellular transport (GO:0032386)	NEW	3.58	0.0	RYR2, CASQ2, TRDN, ANK2, CALM1, MYBPC3
regulation of sequestering of calcium ion (GO:0051282)	-	5.07	0.043	RYR2, CALM1, TRDN
negative regulation of sequestering of calcium ion (GO:0051283)	-	6.04	0.035	RYR2, CALM1, TRDN
regulation of homeostatic process (GO:0032844)	-	3.65	0.0	RYR2, SCN5A, CASQ2, TRDN, ANK2, CALM1, MYBPC3, DMPK
membrane organization (GO:0061024)	-	3.04	0.002	RYR2, SCN5A, CASQ2, LMNA, TRDN, ANK2, CALM1, MYBPC3, DMPK
membrane depolarization (GO:0051899)	-	5.62	0.005	SCN5A, CALM1, DMPK, ANK2, KCNH2
circulatory system process (GO:0003013)	-	4.38	0.0	RYR2, CASQ2, TRPM4, TPM1, TRDN, ANK2, CALM1
calcium ion homeostasis (GO:0055074)	-	3.97	0.027	RYR2, CALM1, TRDN, ANK2, CASQ2, DMPK
membrane depolarization during SA node cell action potential (GO:0086046)	-	8.34	0.014	SCN5A, ANK2
action potential (GO:0001508)	-	5.42	0.0	RYR2, SCN5A, KCNH2, DSG2, ANK2, CALM1, DSP
regulation of ion transmembrane transport (GO:0034765)	-	3.77	0.0	RYR2, SCN5A, CALM1, KCNH2, TRDN, ANK2, CASQ2, DMPK
regulation of transmembrane transport (GO:0034762)	-	3.74	0.0	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, DMPK
muscle organ development (GO:0007517)	NEW	4.98	0.021	CALM1, RYR2, SCN5A, MYBPC3, LMNA
membrane depolarization during action potential (GO:0086010)	-	6.07	0.002	KCNH2, SCN5A, ANK2
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.034	TPM1, CASQ2, DSG2, LAMA4, TRDN, LMNA, DMPK, ANK2, CALM1, MYBPC3, DSP
release of sequestered calcium ion into cytosol (GO:0051209)	-	6.04	0.035	RYR2, CALM1, TRDN
regulation of calcium ion transport into cytosol (GO:0010522)	-	5.23	0.001	CALM1, RYR2, CASQ2, ANK2, TRDN
positive regulation of heart rate (GO:0010460)	-	6.59	0.009	RYR2, SCN5A, TPM1
cellular homeostasis (GO:0019725)	-	3.23	0.031	RYR2, SCN5A, CASQ2, TRDN, ANK2, CALM1, MYBPC3, DMPK
muscle contraction (GO:0006936)	-	4.37	0.0	RYR2, SCN5A, CALM1, KCNH2, TPM1, TRDN, ANK2, CASQ2, MYBPC3
calcium-mediated signaling (GO:0019722)	-	5.24	0.0	RYR2, CALM1, TRDN, ANK2, CASQ2, DMPK
positive regulation of ATPase activity (GO:0032781)	-	5.99	0.001	RYR2, CALM1, MYBPC3, TPM1
response to calcium ion (GO:0051592)	-	4.98	0.001	CASQ2, RYR2, SCN5A, CALM1
negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	-	7.43	0.0	CASQ2, RYR2, CALM1, TRDN
positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)	-	7.78	0.0	CASQ2, RYR2, CALM1, TRDN
regulation of potassium ion transmembrane transport (GO:1901379)	-	5.62	0.002	CASQ2, RYR2, KCNH2, ANK2
response to metal ion (GO:0010038)	-	3.91	0.033	CASQ2, RYR2, SCN5A, CALM1
divalent metal ion transport (GO:0070838)	-	4.15	0.0	RYR2, CASQ2, TRPM4, TRDN, ANK2, CALM1, DMPK
regulation of cardiac muscle contraction (GO:0055117)	-	5.57	0.0	CALM1, RYR2, CASQ2, TRDN, ANK2, SCN5A
system process (GO:0003008)	-	2.3	0.0	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, ANK2, CALM1, MYBPC3
single organism signaling (GO:0044700)	-	3.25	0.0	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, DSG2, DMPK, ANK2, CALM1, DSP
single-multicellular organism process (GO:0044707)	-	1.78	0.0	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, DSG2, ANK2, CALM1, MYBPC3, DSP
muscle system process (GO:0003012)	-	4.18	0.0	RYR2, SCN5A, CASQ2, KCNH2, TPM1, TRDN, ANK2, CALM1, MYBPC3
chemical homeostasis (GO:0048878)	-	2.97	0.002	RYR2, SCN5A, CASQ2, LMNA, KCNH2, TRDN, DMPK, ANK2, CALM1, DSP
positive regulation of heart contraction (GO:0045823)	-	6.15	0.022	RYR2, SCN5A, TPM1
regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)	-	6.68	0.0	CALM1, RYR2, CASQ2, ANK2, TRDN
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO:0010881)	-	6.9	0.0	CALM1, RYR2, CASQ2, ANK2, TRDN
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)	-	6.59	0.0	CASQ2, RYR2, CALM1, ANK2, TRDN
signaling (GO:0023052)	-	3.25	0.002	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, DSG2, DMPK, ANK2, CALM1, DSP
muscle tissue morphogenesis (GO:0060415)	-	5.62	0.0	RYR2, CALM1, TPM1, CASQ2, MYBPC3, DSP
positive regulation of ion transmembrane transporter activity (GO:0032414)	-	5.55	0.0	CASQ2, RYR2, CALM1, ANK2, TRDN
regulation of membrane potential (GO:0042391)	-	3.89	0.0	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, DSG2, TRDN, ANK2, CALM1, DMPK, DSP
negative regulation of transporter activity (GO:0032410)	-	5.59	0.005	CASQ2, RYR2, CALM1, TRDN
positive regulation of transporter activity (GO:0032411)	-	5.44	0.0	CASQ2, RYR2, CALM1, ANK2, TRDN
regulation of ion transmembrane transporter activity (GO:0032412)	-	4.55	0.0	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, DMPK
negative regulation of ion transmembrane transporter activity (GO:0032413)	-	5.74	0.001	CASQ2, RYR2, CALM1, TRDN
regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	-	6.84	0.0	SCN5A, CALM1, ANK2, KCNH2
regulation of membrane repolarization (GO:0060306)	-	6.4	0.0	CALM1, RYR2, CASQ2, KCNH2, ANK2, SCN5A
second-messenger-mediated signaling (GO:0019932)	-	4.65	0.0	RYR2, CALM1, TPM1, TRDN, ANK2, CASQ2, DMPK
actin filament-based process (GO:0030029)	-	3.94	0.0	RYR2, CASQ2, LMNA, TPM1, ANK2, CALM1, MYBPC3, DMPK
G-protein coupled receptor signaling pathway involved in heart process (GO:0086103)	NEW	7.78	0.049	RYR2, CALM1
adrenergic receptor signaling pathway involved in heart process (GO:0086023)	NEW	8.34	0.008	RYR2, CALM1
cardiac conduction (GO:0061337)	-	5.54	0.0	CALM1, TRPM4, KCNH2, DSG2, ANK2, SCN5A, DSP
positive regulation of transport (GO:0051050)	-	2.9	0.004	RYR2, SCN5A, CASQ2, LMNA, KCNH2, TPM1, TRDN, ANK2, CALM1, MYBPC3
Purkinje myocyte to ventricular cardiac muscle cell signaling (GO:0086029)	-	9.04	0.0	RYR2, CASQ2
cellular component organization (GO:0016043)	-	1.24	0.032	TPM1, CALM1, DSG2, LAMA4, TRDN, LMNA, DMPK, ANK2, CASQ2, MYBPC3, DSP
inorganic cation transmembrane transport (GO:0098662)	-	3.55	0.001	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, ANK2, CALM1
inorganic ion transmembrane transport (GO:0098660)	-	3.38	0.0	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, ANK2, CALM1, DMPK
regulation of skeletal muscle contraction by calcium ion signaling (GO:0014722)	NEW	8.12	0.028	RYR2, DMPK
regulation of molecular function (GO:0065009)	-	1.78	0.034	RYR2, CALM1, LMNA, TPM1, TRDN, ANK2, CASQ2, MYBPC3, DMPK
regulation of biological quality (GO:0065008)	-	1.68	0.0	TPM1, SCN5A, CASQ2, TRPM4, KCNH2, RYR2, DSG2, TRDN, ANK2, CALM1, MYBPC3, DMPK, DSP
regulation of heart contraction (GO:0008016)	-	4.35	0.0	RYR2, SCN5A, CASQ2, DSG2, TRPM4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, MYBPC3, DSP
divalent inorganic cation homeostasis (GO:0072507)	-	3.9	0.035	RYR2, CASQ2, TRDN, ANK2, CALM1, DMPK
cation transport (GO:0006812)	-	3.11	0.001	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, ANK2, CALM1, DMPK
ion transport (GO:0006811)	-	2.66	0.024	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, ANK2, CALM1, DMPK
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0014808)	-	7.78	0.007	RYR2, TRDN
regulation of atrial cardiac muscle cell membrane repolarization (GO:0060372)	NEW	7.94	0.038	CALM1, SCN5A
tissue development (GO:0009888)	-	3.27	0.041	RYR2, SCN5A, CASQ2, TPM1, DMPK, ANK2, CALM1, MYBPC3, DSP
response to caffeine (GO:0031000)	-	6.84	0.003	CALM1, RYR2, CASQ2
calcium ion transport (GO:0006816)	-	4.33	0.0	RYR2, CASQ2, TRPM4, TRDN, ANK2, CALM1, DMPK
single-organism membrane organization (GO:0044802)	-	3.19	0.0	RYR2, SCN5A, CASQ2, LMNA, TRDN, ANK2, CALM1, MYBPC3, DMPK
regulation of multicellular organismal process (GO:0051239)	-	1.87	0.0	RYR2, SCN5A, CASQ2, DSG2, LAMA4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, MYBPC3, TRPM4, DSP
positive regulation of cell communication by electrical coupling (GO:0010650)	NEW	9.04	0.008	RYR2, TRDN
cellular divalent inorganic cation homeostasis (GO:0072503)	-	3.96	0.023	RYR2, CASQ2, TRDN, ANK2, CALM1, DMPK
regulation of heart rate by chemical signal (GO:0003062)	-	8.12	0.02	TPM1, KCNH2
cardiac muscle cell action potential involved in contraction (GO:0086002)	-	6.47	0.0	RYR2, SCN5A, KCNH2, DSG2, ANK2, CALM1, DSP
regulation of cardiac muscle cell membrane potential (GO:0086036)	NEW	7.65	0.007	RYR2, ANK2, TRDN
regulation of transmembrane transporter activity (GO:0022898)	-	4.52	0.0	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, DMPK
sarcoplasmic reticulum calcium ion transport (GO:0070296)	-	7.33	0.0	RYR2, CASQ2, ANK2, TRDN
negative regulation of cation channel activity (GO:2001258)	-	6.26	0.0	CALM1, RYR2, CASQ2, TRDN
positive regulation of cation channel activity (GO:2001259)	-	6.17	0.0	CASQ2, RYR2, CALM1, ANK2, TRDN
regulation of cation channel activity (GO:2001257)	-	5.27	0.0	RYR2, CASQ2, TRDN, ANK2, CALM1, DMPK
multicellular organismal signaling (GO:0035637)	-	5.36	0.0	CALM1, TRPM4, KCNH2, DSG2, ANK2, SCN5A, DSP
ion homeostasis (GO:0050801)	-	3.42	0.01	RYR2, SCN5A, CALM1, KCNH2, TRDN, ANK2, CASQ2, DMPK
striated muscle contraction (GO:0006941)	-	5.37	0.0	RYR2, SCN5A, CALM1, KCNH2, TPM1, ANK2, CASQ2, MYBPC3
regulation of striated muscle contraction (GO:0006942)	-	5.38	0.0	RYR2, SCN5A, CASQ2, TRDN, ANK2, CALM1, MYBPC3, DMPK
regulation of cell communication by electrical coupling (GO:0010649)	-	7.33	0.0	CALM1, RYR2, CASQ2, TRDN
cellular response to chemical stimulus (GO:0070887)	-	2.57	0.044	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, LMNA, CALM1
response to chemical (GO:0042221)	-	1.98	0.003	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TPM1, DSG2, TRDN, ANK2, CALM1
muscle structure development (GO:0061061)	NEW	4.96	0.027	CALM1, RYR2, SCN5A, MYBPC3, LMNA
response to purine-containing compound (GO:0014074)	-	4.67	0.002	RYR2, CASQ2, KCNH2, TPM1, ANK2, CALM1
cardiac muscle contraction (GO:0060048)	-	5.88	0.0	RYR2, SCN5A, CASQ2, KCNH2, TPM1, ANK2, CALM1, MYBPC3
response to organic cyclic compound (GO:0014070)	-	3.07	0.0	RYR2, SCN5A, CASQ2, LMNA, KCNH2, TPM1, TRDN, DSG2, ANK2, CALM1, DMPK
regulation of cardiac muscle cell contraction (GO:0086004)	-	6.51	0.027	CALM1, SCN5A, ANK2
ventricular cardiac muscle cell action potential (GO:0086005)	-	7.02	0.0	RYR2, CALM1, KCNH2, DSG2, ANK2, SCN5A, DSP
cardiac muscle cell action potential (GO:0086001)	-	6.33	0.0	RYR2, SCN5A, KCNH2, DSG2, ANK2, CALM1, DSP
regulation of system process (GO:0044057)	-	3.53	0.0	RYR2, SCN5A, CASQ2, DSG2, TRPM4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, MYBPC3, DSP
cardiac muscle hypertrophy (GO:0003300)	NEW	6.84	0.014	RYR2, CALM1, TPM1
regulation of heart rate (GO:0002027)	-	5.29	0.0	RYR2, SCN5A, CASQ2, KCNH2, TPM1, TRDN, DSG2, ANK2, CALM1, MYBPC3, DSP
regulation of transporter activity (GO:0032409)	-	4.45	0.0	RYR2, SCN5A, CALM1, KCNH2, TRDN, ANK2, CASQ2, DMPK
regulation of sodium ion transport (GO:0002028)	-	5.4	0.016	CALM1, SCN5A, DMPK, ANK2
striated muscle cell development (GO:0055002)	NEW	5.42	0.044	RYR2, CALM1, TPM1, LMNA
multicellular organismal process (GO:0032501)	-	1.45	0.0	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, DSG2, ANK2, CALM1, MYBPC3, DSP
regulation of actin filament-based movement (GO:1903115)	-	6.33	0.0	CALM1, MYBPC3, SCN5A, ANK2
regulation of calcium ion transmembrane transporter activity (GO:1901019)	-	5.49	0.0	RYR2, CALM1, TRDN, ANK2, CASQ2, DMPK
cardiac muscle tissue morphogenesis (GO:0055008)	-	5.8	0.0	RYR2, CASQ2, TPM1, CALM1, MYBPC3, DSP
cellular calcium ion homeostasis (GO:0006874)	-	4.01	0.037	RYR2, CALM1, TRDN, ANK2, CASQ2, DMPK
regulation of actin filament-based process (GO:0032970)	-	3.97	0.037	RYR2, CALM1, TPM1, ANK2, SCN5A, MYBPC3, DMPK
positive regulation of ion transport (GO:0043270)	-	4.36	0.003	RYR2, CALM1, KCNH2, ANK2, SCN5A, MYBPC3
negative regulation of ion transport (GO:0043271)	-	4.94	0.032	CALM1, KCNH2, RYR2, CASQ2
cell-cell signaling involved in cardiac conduction (GO:0086019)	-	8.12	0.008	RYR2, CASQ2
microtubule-based process (GO:0007017)	-	3.54	0.029	RYR2, CALM1, LMNA, TRDN, ANK2, CASQ2, DMPK
metal ion transport (GO:0030001)	-	3.36	0.001	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TRDN, ANK2, CALM1, DMPK
cation homeostasis (GO:0055080)	-	3.46	0.004	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, DMPK
membrane depolarization during cardiac muscle cell action potential (GO:0086012)	-	7.09	0.014	SCN5A, ANK2
regulation of localization (GO:0032879)	-	1.94	0.0	RYR2, SCN5A, CASQ2, LMNA, LAMA4, KCNH2, TPM1, TRDN, ANK2, CALM1, MYBPC3, DMPK
transmembrane transport (GO:0055085)	-	2.72	0.011	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, ANK2, CALM1, DMPK
divalent inorganic cation transport (GO:0072511)	-	4.13	0.034	RYR2, CASQ2, TRPM4, TRDN, ANK2, CALM1, DMPK
vasoconstriction (GO:0042310)	NEW	6.36	0.043	TRPM4, CALM1, ANK2
detection of calcium ion (GO:0005513)	-	7.24	0.0	CALM1, RYR2, CASQ2
regulation of heart rate by cardiac conduction (GO:0086091)	-	6.33	0.0	DSP, KCNH2, SCN5A, ANK2, DSG2
myosin filament assembly (GO:0031034)	NEW	8.63	0.028	MYBPC3, TPM1
myosin filament organization (GO:0031033)	NEW	8.63	0.028	MYBPC3, TPM1
actomyosin structure organization (GO:0031032)	-	5.4	0.0	CALM1, MYBPC3, CASQ2, TPM1, DMPK
regulation of cellular localization (GO:0060341)	-	3.03	0.042	RYR2, CASQ2, LMNA, KCNH2, TPM1, TRDN, ANK2, CALM1, MYBPC3, DMPK
ventricular cardiac muscle tissue morphogenesis (GO:0055010)	-	6.07	0.0	DSP, RYR2, MYBPC3, TPM1
actin cytoskeleton organization (GO:0030036)	-	4.1	0.002	RYR2, CASQ2, TPM1, ANK2, CALM1, MYBPC3, DMPK
regulation of calcium ion transmembrane transport (GO:1903169)	-	4.98	0.0	RYR2, CASQ2, TRDN, ANK2, CALM1, DMPK
negative regulation of potassium ion transport (GO:0043267)	-	6.26	0.009	KCNH2, RYR2, CASQ2
regulation of potassium ion transport (GO:0043266)	-	5.31	0.0	CASQ2, RYR2, CALM1, ANK2, KCNH2
cellular response to drug (GO:0035690)	NEW	5.48	0.012	CASQ2, RYR2, CALM1, KCNH2
Purkinje myocyte to ventricular cardiac muscle cell communication (GO:0086068)	-	9.04	0.0	RYR2, CASQ2
bundle of His cell to Purkinje myocyte communication (GO:0086069)	NEW	9.04	0.0	SCN5A, DSP, DSG2
cell death (GO:0008219)	-	3.05	0.018	RYR2, CALM1, LMNA, KCNH2, DSG2, DSP, ANK2, SCN5A, MYBPC3, DMPK
cell communication involved in cardiac conduction (GO:0086065)	-	6.73	0.0	RYR2, SCN5A, CASQ2, DSG2, ANK2, CALM1, DSP
regulation of ion transport (GO:0043269)	-	3.4	0.001	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, MYBPC3, DMPK
regulation of ATPase activity (GO:0043462)	-	5.59	0.001	RYR2, CALM1, MYBPC3, TPM1
cellular response to purine-containing compound (GO:0071415)	-	7.53	0.014	CASQ2, RYR2, CALM1
regulation of muscle contraction (GO:0006937)	-	4.75	0.0	RYR2, SCN5A, CALM1, TPM1, TRDN, ANK2, CASQ2, MYBPC3, DMPK
protein homooligomerization (GO:0051260)	NEW	4.21	0.031	RYR2, CALM1, KCNH2, TPM1, ANK2, DMPK
cellular response to caffeine (GO:0071313)	-	7.65	0.014	CASQ2, RYR2, CALM1
positive regulation of calcium ion transmembrane transporter activity (GO:1901021)	-	6.36	0.0	CASQ2, RYR2, CALM1, ANK2, TRDN
negative regulation of calcium ion transmembrane transporter activity (GO:1901020)	-	6.59	0.0	CALM1, RYR2, CASQ2, TRDN
regulation of high voltage-gated calcium channel activity (GO:1901841)	NEW	7.65	0.008	RYR2, CALM1
response to organophosphorus (GO:0046683)	NEW	4.79	0.001	RYR2, CALM1, KCNH2, TPM1, ANK2, CASQ2
regulation of cell communication by electrical coupling involved in cardiac conduction (GO:1901844)	-	7.78	0.007	RYR2, CALM1, TRDN
cytosolic calcium ion transport (GO:0060401)	-	5.74	0.002	RYR2, CALM1, ANK2, TRDN
calcium ion transport into cytosol (GO:0060402)	-	5.78	0.002	RYR2, CALM1, ANK2, TRDN
regulation of metal ion transport (GO:0010959)	-	3.94	0.0	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, MYBPC3, DMPK
ion transmembrane transport (GO:0034220)	-	3.08	0.017	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, TRDN, ANK2, CALM1, DMPK
single-organism cellular process (GO:0044763)	-	0.65	0.041	RYR2, SCN5A, CASQ2, LMNA, LAMA4, KCNH2, TPM1, DSG2, TRDN, ANK2, CALM1, MYBPC3, DMPK, TRPM4, DSP
regulation of muscle system process (GO:0090257)	-	4.51	0.0	RYR2, SCN5A, CASQ2, TPM1, TRDN, ANK2, CALM1, MYBPC3, DMPK
metal ion homeostasis (GO:0055065)	-	3.61	0.002	RYR2, SCN5A, CASQ2, KCNH2, TRDN, ANK2, CALM1, DMPK
cell communication (GO:0007154)	-	3.04	0.0	RYR2, SCN5A, CASQ2, KCNH2, DSG2, ANK2, CALM1, DSP
SA node cell to atrial cardiac muscle cell communication (GO:0086070)	NEW	9.04	0.008	SCN5A, ANK2
regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)	-	6.51	0.0	CALM1, RYR2, CASQ2, TRDN
regulation of cellular component movement (GO:0051270)	-	3.08	0.013	RYR2, CALM1, LMNA, LAMA4, TPM1, ANK2, SCN5A, MYBPC3, DMPK
cytoskeleton organization (GO:0007010)	-	3.22	0.0	RYR2, SCN5A, CASQ2, LMNA, TPM1, TRDN, DMPK, ANK2, CALM1, MYBPC3, DSP
regulation of release of sequestered calcium ion into cytosol (GO:0051279)	-	5.44	0.0	CALM1, RYR2, CASQ2, ANK2, TRDN
regulation of calcium ion transport (GO:0051924)	-	4.38	0.004	RYR2, CASQ2, TRDN, ANK2, CALM1, DMPK
regulation of potassium ion transmembrane transporter activity (GO:1901016)	-	6.02	0.0	CASQ2, RYR2, KCNH2, ANK2
regulation of ion homeostasis (GO:2000021)	-	4.44	0.0	RYR2, SCN5A, CALM1, TRDN, ANK2, CASQ2, MYBPC3
cellular component disassembly involved in execution phase of apoptosis (GO:0006921)	NEW	6.47	0.008	DSP, LMNA, DSG2
sarcomere organization (GO:0045214)	-	6.4	0.001	CASQ2, MYBPC3, CALM1, TPM1
cation transmembrane transport (GO:0098655)	-	3.43	0.005	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TPM1, ANK2, CALM1

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	14	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TPM1, DSG2, TRDN, ANK2, CALM1, MYBPC3, DMPK, DSP
intracellular part (GO:0044424)	0.28	13	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, MYBPC3, DSP
membrane (GO:0016020)	0.68	13	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TPM1, DSG2, TRDN, ANK2, CALM1, DMPK, DSP
organelle (GO:0043226)	0.4	13	RYR2, SCN5A, CASQ2, LMNA, LAMA4, TPM1, TRDN, DSG2, ANK2, CALM1, DMPK, TRPM4, DSP
membrane part (GO:0044425)	0.95	12	RYR2, SCN5A, CASQ2, DSG2, TRPM4, KCNH2, TPM1, TRDN, DMPK, ANK2, CALM1, DSP
cytoplasmic part (GO:0044444)	0.82	12	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TPM1, TRDN, ANK2, CALM1, MYBPC3, DMPK
organelle part (GO:0044422)	0.79	12	RYR2, SCN5A, CASQ2, LMNA, TRPM4, TPM1, TRDN, DMPK, ANK2, CALM1, MYBPC3, DSP
intracellular organelle (GO:0043229)	0.51	11	RYR2, SCN5A, CASQ2, LMNA, TRPM4, TPM1, TRDN, DMPK, ANK2, CALM1, DSP
membrane-bounded organelle (GO:0043227)	0.47	11	RYR2, SCN5A, CASQ2, LAMA4, TRDN, DSG2, LMNA, CALM1, DMPK, TRPM4, DSP
intracellular organelle part (GO:0044446)	0.81	10	RYR2, CALM1, TRPM4, TPM1, TRDN, DMPK, LMNA, CASQ2, MYBPC3, DSP
plasma membrane (GO:0005886)	1.39	10	RYR2, CALM1, TRPM4, KCNH2, DSG2, TRDN, ANK2, SCN5A, DMPK, DSP
plasma membrane part (GO:0044459)	1.95	9	TPM1, SCN5A, CASQ2, KCNH2, TRDN, DSG2, ANK2, CALM1, DSP
intracellular membrane-bounded organelle (GO:0043231)	0.6	9	RYR2, SCN5A, CASQ2, TRPM4, TRDN, DSP, LMNA, CALM1, DMPK
protein complex (GO:0043234)	1.51	8	RYR2, SCN5A, CASQ2, KCNH2, TPM1, TRDN, CALM1, MYBPC3
cytoplasm (GO:0005737)	1.01	8	TPM1, CALM1, LMNA, TRDN, DMPK, ANK2, CASQ2, DSP
integral component of membrane (GO:0016021)	1.14	8	RYR2, SCN5A, TRPM4, KCNH2, TPM1, TRDN, DSG2, DMPK
macromolecular complex (GO:0032991)	1.35	8	RYR2, SCN5A, CASQ2, KCNH2, TPM1, TRDN, CALM1, MYBPC3
intrinsic component of membrane (GO:0031224)	1.13	8	RYR2, SCN5A, TRPM4, KCNH2, TPM1, DSG2, TRDN, DMPK
cytosol (GO:0005829)	1.68	7	TPM1, CALM1, LMNA, TRPM4, ANK2, MYBPC3, DMPK
contractile fiber part (GO:0044449)	4.53	7	RYR2, SCN5A, CASQ2, TPM1, ANK2, CALM1, MYBPC3
transmembrane transporter complex (GO:1902495)	4.06	6	CALM1, RYR2, SCN5A, KCNH2, TRDN, CASQ2
endoplasmic reticulum (GO:0005783)	2.56	6	RYR2, SCN5A, TRPM4, TRDN, CASQ2, DMPK
transporter complex (GO:1990351)	4.04	6	CALM1, RYR2, SCN5A, KCNH2, TRDN, CASQ2
membrane protein complex (GO:0098796)	2.84	6	CALM1, RYR2, CASQ2, KCNH2, TRDN, SCN5A
ion channel complex (GO:0034702)	4.18	6	CALM1, RYR2, CASQ2, KCNH2, TRDN, SCN5A
cation channel complex (GO:0034703)	4.69	6	RYR2, CALM1, KCNH2, CASQ2, TRDN, SCN5A
plasma membrane region (GO:0098590)	2.97	5	DSP, TPM1, SCN5A, ANK2, DSG2
extracellular vesicle (GO:1903561)	1.89	5	DSP, RYR2, CALM1, LAMA4, DSG2
extracellular organelle (GO:0043230)	1.89	5	DSP, RYR2, CALM1, LAMA4, DSG2
vesicle (GO:0031982)	1.64	5	DSP, RYR2, CALM1, LAMA4, DSG2
extracellular exosome (GO:0070062)	1.89	5	DSP, RYR2, CALM1, LAMA4, DSG2
membrane-bounded vesicle (GO:0031988)	1.71	5	DSP, RYR2, CALM1, LAMA4, DSG2
plasma membrane protein complex (GO:0098797)	3.55	5	CASQ2, SCN5A, CALM1, TRDN, KCNH2
cytoskeletal part (GO:0044430)	2.49	5	DSP, MYBPC3, CALM1, TPM1, LMNA
intracellular (GO:0005622)	2.37	5	KCNH2, RYR2, CASQ2, SCN5A, ANK2
extracellular region part (GO:0044421)	1.57	5	DSP, RYR2, CALM1, LAMA4, DSG2
organelle membrane (GO:0031090)	1.97	5	RYR2, DMPK, CASQ2, LMNA, TRDN
cytoskeleton (GO:0005856)	2.55	4	TPM1, CALM1, DSP, ANK2
intercalated disc (GO:0014704)	5.93	4	DSP, SCN5A, ANK2, DSG2
bounding membrane of organelle (GO:0098588)	2.39	4	RYR2, CASQ2, DMPK, TRDN
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	4	TPM1, CALM1, DSP, ANK2
sarcomere (GO:0030017)	5.95	4	RYR2, CALM1, MYBPC3, TPM1
cell-cell contact zone (GO:0044291)	5.69	4	DSP, SCN5A, ANK2, DSG2
sarcoplasmic reticulum (GO:0016529)	5.81	4	RYR2, CASQ2, DMPK, TRDN
endoplasmic reticulum membrane (GO:0005789)	2.95	4	RYR2, CASQ2, DMPK, TRDN
sarcoplasmic reticulum membrane (GO:0033017)	6.14	4	RYR2, CASQ2, DMPK, TRDN
endoplasmic reticulum part (GO:0044432)	2.73	4	RYR2, CASQ2, DMPK, TRDN
calcium channel complex (GO:0034704)	5.72	4	CASQ2, RYR2, CALM1, TRDN
non-membrane-bounded organelle (GO:0043228)	1.76	4	TPM1, CALM1, DSP, ANK2
nuclear part (GO:0044428)	1.55	4	TRPM4, CALM1, DMPK, LMNA
Z disc (GO:0030018)	5.11	4	CASQ2, RYR2, SCN5A, ANK2
cell-cell junction (GO:0005911)	3.85	4	DSP, SCN5A, ANK2, DSG2
nucleus (GO:0005634)	1.07	4	DMPK, CALM1, DSP, LMNA
cell junction (GO:0030054)	2.75	4	DSP, SCN5A, ANK2, DSG2
supramolecular fiber (GO:0099512)	3.31	3	CALM1, DSP, LMNA
polymeric cytoskeletal fiber (GO:0099513)	3.31	3	CALM1, DSP, LMNA
cell surface (GO:0009986)	3.44	3	KCNH2, SCN5A, DSG2
nucleoplasm (GO:0005654)	1.89	3	TRPM4, CALM1, LMNA
neuron part (GO:0097458)	2.64	3	TRPM4, CALM1, ANK2
junctional sarcoplasmic reticulum membrane (GO:0014701)	7.5	3	RYR2, CASQ2, TRDN
cell projection (GO:0042995)	2.47	3	TPM1, CALM1, ANK2
membrane raft (GO:0045121)	4.18	2	SCN5A, ANK2
membrane-enclosed lumen (GO:0031974)	3.05	2	CASQ2, TRDN
potassium channel complex (GO:0034705)	5.32	2	CALM1, KCNH2
lateral plasma membrane (GO:0016328)	5.89	2	SCN5A, DSG2
desmosome (GO:0030057)	6.58	2	DSP, DSG2
A band (GO:0031672)	7.09	2	MYBPC3, ANK2
T-tubule (GO:0030315)	6.09	2	SCN5A, ANK2
extracellular region (GO:0005576)	2.18	2	LAMA4, CALM1
neuron projection (GO:0043005)	3.12	2	CALM1, ANK2
perinuclear region of cytoplasm (GO:0048471)	3.35	2	KCNH2, LMNA
sarcoplasmic reticulum lumen (GO:0033018)	7.72	2	CASQ2, TRDN
anchoring junction (GO:0070161)	3.61	2	DSP, DSG2
sarcolemma (GO:0042383)	5.2	2	SCN5A, ANK2
apical plasma membrane (GO:0016324)	4.13	2	ANK2, DSG2
junctional membrane complex (GO:0030314)	7.86	2	CASQ2, TRDN
membrane region (GO:0098589)	3.95	2	SCN5A, ANK2
nuclear membrane (GO:0031965)	4.2	2	DMPK, LMNA
voltage-gated potassium channel complex (GO:0008076)	5.34	2	CALM1, KCNH2
basolateral plasma membrane (GO:0016323)	4.56	2	DSP, ANK2
intermediate filament (GO:0005882)	4.48	2	DSP, LMNA
endoplasmic reticulum lumen (GO:0005788)	4.5	2	CASQ2, TRDN
organelle lumen (GO:0043233)	3.05	2	CASQ2, TRDN
cell projection part (GO:0044463)	2.97	2	TPM1, CALM1
intracellular organelle lumen (GO:0070013)	3.05	2	CASQ2, TRDN
voltage-gated calcium channel complex (GO:0005891)	6.11	2	CASQ2, TRDN
membrane microdomain (GO:0098857)	4.17	2	SCN5A, ANK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
plasma membrane region (GO:0098590)	-	2.97	0.023	RYR2, CALM1, DSG2, DSP, ANK2, MYBPC3, DMPK
A band (GO:0031672)	-	7.09	0.004	MYBPC3, ANK2
endoplasmic reticulum (GO:0005783)	-	2.56	0.044	RYR2, SCN5A, CASQ2, TRPM4, KCNH2, TRDN, DMPK, ANK2, CALM1, MYBPC3, DSP
envelope (GO:0031975)	NEW	4.62	0.001	DSP, CALM1, KCNH2, LMNA, ANK2
intercalated disc (GO:0014704)	-	5.93	0.0	CALM1, RYR2, SCN5A, DSP, ANK2
sarcomere (GO:0030017)	-	5.95	0.0	MYBPC3, CALM1, TPM1
potassium channel complex (GO:0034705)	-	5.32	0.049	CALM1, KCNH2, ANK2
ion channel complex (GO:0034702)	-	4.18	0.001	CALM1, RYR2, CASQ2, KCNH2, ANK2, SCN5A
cation channel complex (GO:0034703)	-	4.69	0.0	RYR2, CALM1, KCNH2, CASQ2, ANK2, SCN5A
transmembrane transporter complex (GO:1902495)	-	4.06	0.0	RYR2, SCN5A, CASQ2, KCNH2, ANK2, CALM1, DMPK
intrinsic component of plasma membrane (GO:0031226)	NEW	2.53	0.012	CALM1, SCN5A, ANK2
desmosome (GO:0030057)	-	6.58	0.018	DSP, DSG2
cell junction (GO:0030054)	-	2.75	0.005	TPM1, CALM1, LMNA, RYR2, DSG2, DMPK, ANK2, SCN5A, MYBPC3, DSP
nuclear envelope (GO:0005635)	NEW	4.72	0.001	DSP, CALM1, KCNH2, LMNA, ANK2
I band (GO:0031674)	NEW	6.67	0.0	CALM1, RYR2, CASQ2, TPM1
sarcoplasmic reticulum membrane (GO:0033017)	-	6.14	0.0	CASQ2, RYR2, CALM1, DMPK, TRDN
T-tubule (GO:0030315)	-	6.09	0.0	CALM1, RYR2, SCN5A, ANK2
Z disc (GO:0030018)	-	5.11	0.0	RYR2, SCN5A, CASQ2, LMNA, KCNH2, TRDN, ANK2, CALM1, MYBPC3
leading edge membrane (GO:0031256)	NEW	4.9	0.003	CALM1, RYR2, KCNH2, TPM1, ANK2
neuronal cell body (GO:0043025)	NEW	3.9	0.022	RYR2, SCN5A, KCNH2, ANK2, CALM1, MYBPC3
sarcoplasmic reticulum lumen (GO:0033018)	-	7.72	0.0	RYR2, CASQ2, TRDN
cell body (GO:0044297)	NEW	3.74	0.004	RYR2, SCN5A, KCNH2, ANK2, CALM1, MYBPC3, DMPK
sarcolemma (GO:0042383)	-	5.2	0.007	CALM1, RYR2, SCN5A, ANK2
smooth endoplasmic reticulum (GO:0005790)	NEW	6.58	0.001	RYR2, CALM1, DMPK
lateral plasma membrane (GO:0016328)	-	5.89	0.014	CALM1, SCN5A, DSG2
nuclear membrane (GO:0031965)	-	4.2	0.047	RYR2, DMPK, CALM1, DSP, LMNA
cell-cell contact zone (GO:0044291)	-	5.69	0.0	CALM1, RYR2, SCN5A, DSP, ANK2
membrane region (GO:0098589)	-	3.95	0.0	RYR2, SCN5A, CASQ2, DSG2, KCNH2, TPM1, TRDN, LMNA, DMPK, ANK2, CALM1, MYBPC3, DSP
transporter complex (GO:1990351)	-	4.04	0.0	CALM1, RYR2, CASQ2, KCNH2, ANK2, SCN5A, DMPK
voltage-gated potassium channel complex (GO:0008076)	-	5.34	0.049	CALM1, KCNH2, ANK2
organelle envelope (GO:0031967)	NEW	4.63	0.001	DSP, CALM1, KCNH2, LMNA, ANK2
neuron projection membrane (GO:0032589)	NEW	6.19	0.02	CALM1, KCNH2, ANK2
cell-cell junction (GO:0005911)	-	3.85	0.015	TPM1, SCN5A, DSG2, ANK2, CALM1, DSP
plasma membrane (GO:0005886)	-	1.39	0.019	RYR2, SCN5A, CASQ2, LMNA, TRPM4, KCNH2, TPM1, DSG2, TRDN, ANK2, CALM1, MYBPC3, DMPK, DSP
junctional sarcoplasmic reticulum membrane (GO:0014701)	-	7.5	0.0	RYR2, CASQ2, TRDN
protein complex (GO:0043234)	-	1.51	0.026	RYR2, SCN5A, CASQ2, LAMA4, KCNH2, TPM1, TRDN, LMNA, CALM1, MYBPC3
filopodium (GO:0030175)	NEW	5.48	0.002	CALM1, RYR2, SCN5A, LMNA
plasma membrane part (GO:0044459)	-	1.95	0.027	TPM1, SCN5A, CASQ2, LMNA, KCNH2, RYR2, DSG2, DMPK, ANK2, CALM1, MYBPC3, DSP
membrane raft (GO:0045121)	-	4.18	0.033	SCN5A, RYR2, CALM1, TPM1, ANK2
sarcoplasmic reticulum (GO:0016529)	-	5.81	0.004	RYR2, CASQ2, TRDN
contractile fiber (GO:0043292)	NEW	5.81	0.0	MYBPC3, CALM1, TPM1, ANK2
contractile fiber part (GO:0044449)	-	4.53	0.0	RYR2, SCN5A, CASQ2, LMNA, KCNH2, TPM1, TRDN, ANK2, CALM1, MYBPC3