Disease table of SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR OMIM ID: 147250

Gene-disease associations table

GeneAssociated with SOLITARY MEDIAN MAXILLARY CENTRAL INCISOR inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SHHClinVar, OMIM, HUMSAVARHGNC link7q36.34PS300345, 269160, PS236100, 147250
SIX3ClinVarHGNC link2p213269160, PS236100, 147250

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SHHYES3STAT3, PAX3, SOX90
SIX3YES2PAX6, PROX10
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SHHSIX3Yesactivation, binding7SALL1, PITX2, PLP1, POU3F4, BMP4, WNT1, PAX6

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182SHH, SIX3
protein binding (GO:0005515) 0.462SHH, SIX3

NET-GE enrichment

Term New enriched termICP valueGenes
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity (GO:0003705) NEW5.230.029SHH, SIX3
RNA polymerase II transcription factor binding transcription factor activity (GO:0001076) NEW4.840.038SHH, SIX3
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
protein localization (GO:0008104) 2.362SHH, SIX3
regulation of primary metabolic process (GO:0080090) 1.082SHH, SIX3
regulation of metabolic process (GO:0019222) 1.022SHH, SIX3
negative regulation of response to stimulus (GO:0048585) 2.522SHH, SIX3
regulation of response to stimulus (GO:0048583) 1.542SHH, SIX3
regulation of Wnt signaling pathway (GO:0030111) 3.982SHH, SIX3
regulation of macromolecule biosynthetic process (GO:0010556) 1.432SHH, SIX3
negative regulation of macromolecule metabolic process (GO:0010605) 2.012SHH, SIX3
positive regulation of macromolecule metabolic process (GO:0010604) 1.812SHH, SIX3
negative regulation of signal transduction (GO:0009968) 2.752SHH, SIX3
cellular macromolecule localization (GO:0070727) 3.12SHH, SIX3
regulation of signal transduction (GO:0009966) 1.842SHH, SIX3
cellular developmental process (GO:0048869) 1.822SHH, SIX3
negative regulation of neuron differentiation (GO:0045665) 4.452SHH, SIX3
regulation of neuron differentiation (GO:0045664) 3.392SHH, SIX3
animal organ development (GO:0048513) 2.532SHH, SIX3
negative regulation of cell development (GO:0010721) 4.022SHH, SIX3
positive regulation of biological process (GO:0048518) 1.22SHH, SIX3
negative regulation of biological process (GO:0048519) 1.332SHH, SIX3
macromolecule localization (GO:0033036) 2.342SHH, SIX3
regulation of cell proliferation (GO:0042127) 2.412SHH, SIX3
neural precursor cell proliferation (GO:0061351) 5.72SHH, SIX3
regulation of macromolecule metabolic process (GO:0060255) 1.082SHH, SIX3
regionalization (GO:0003002) 4.242SHH, SIX3
regulation of RNA biosynthetic process (GO:2001141) 1.552SHH, SIX3
single-multicellular organism process (GO:0044707) 1.782SHH, SIX3
cell motility (GO:0048870) 3.022SHH, SIX3
negative regulation of cell communication (GO:0010648) 2.662SHH, SIX3
negative regulation of metabolic process (GO:0009892) 1.932SHH, SIX3
positive regulation of metabolic process (GO:0009893) 1.742SHH, SIX3
negative regulation of biosynthetic process (GO:0009890) 2.472SHH, SIX3
positive regulation of biosynthetic process (GO:0009891) 2.292SHH, SIX3
movement of cell or subcellular component (GO:0006928) 2.612SHH, SIX3
negative regulation of gene expression (GO:0010629) 2.482SHH, SIX3
positive regulation of gene expression (GO:0010628) 2.352SHH, SIX3
regulation of biological process (GO:0050789) 0.452SHH, SIX3
regulation of cell communication (GO:0010646) 1.732SHH, SIX3
biological regulation (GO:0065007) 0.392SHH, SIX3
cell migration (GO:0016477) 3.122SHH, SIX3
regulation of developmental process (GO:0050793) 2.12SHH, SIX3
transport (GO:0006810) 1.512SHH, SIX3
regulation of biosynthetic process (GO:0009889) 1.372SHH, SIX3
regulation of cellular process (GO:0050794) 0.52SHH, SIX3
regulation of multicellular organismal process (GO:0051239) 1.872SHH, SIX3
establishment of localization (GO:0051234) 1.482SHH, SIX3
negative regulation of RNA biosynthetic process (GO:1902679) 2.72SHH, SIX3
dorsal/ventral pattern formation (GO:0009953) 5.62SHH, SIX3
anterior/posterior pattern specification (GO:0009952) 4.712SHH, SIX3
sensory organ development (GO:0007423) 4.822SHH, SIX3
regulation of transcription, DNA-templated (GO:0006355) 1.562SHH, SIX3
negative regulation of nervous system development (GO:0051961) 4.152SHH, SIX3
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242SHH, SIX3
camera-type eye development (GO:0043010) 5.362SHH, SIX3
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532SHH, SIX3
metabolic process (GO:0008152) 0.582SHH, SIX3
cell differentiation (GO:0030154) 2.142SHH, SIX3
negative regulation of signaling (GO:0023057) 2.652SHH, SIX3
regulation of cell development (GO:0060284) 3.012SHH, SIX3
regulation of signaling (GO:0023051) 1.722SHH, SIX3
anatomical structure morphogenesis (GO:0009653) 2.532SHH, SIX3
single-organism process (GO:0044699) 0.482SHH, SIX3
regulation of neurogenesis (GO:0050767) 3.212SHH, SIX3
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392SHH, SIX3
negative regulation of multicellular organismal process (GO:0051241) 2.842SHH, SIX3
negative regulation of neurogenesis (GO:0050768) 4.222SHH, SIX3
regulation of neural precursor cell proliferation (GO:2000177) 5.452SHH, SIX3
regulation of stem cell proliferation (GO:0072091) 5.62SHH, SIX3
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562SHH, SIX3
multicellular organismal process (GO:0032501) 1.452SHH, SIX3
cell proliferation (GO:0008283) 3.232SHH, SIX3
cellular process (GO:0009987) 0.262SHH, SIX3
regulation of nucleic acid-templated transcription (GO:1903506) 1.552SHH, SIX3
negative regulation of nucleic acid-templated transcription (GO:1903507) 2.712SHH, SIX3
negative regulation of cell differentiation (GO:0045596) 3.332SHH, SIX3
regulation of cell differentiation (GO:0045595) 2.422SHH, SIX3
eye development (GO:0001654) 5.072SHH, SIX3
positive regulation of transcription, DNA-templated (GO:0045893) 2.562SHH, SIX3
negative regulation of developmental process (GO:0051093) 3.172SHH, SIX3
negative regulation of RNA metabolic process (GO:0051253) 2.662SHH, SIX3
regulation of RNA metabolic process (GO:0051252) 1.522SHH, SIX3
positive regulation of RNA metabolic process (GO:0051254) 2.512SHH, SIX3
macromolecule metabolic process (GO:0043170) 0.832SHH, SIX3
positive regulation of RNA biosynthetic process (GO:1902680) 2.542SHH, SIX3
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812SHH, SIX3
protein localization to organelle (GO:0033365) 3.572SHH, SIX3
gland development (GO:0048732) 4.152SHH, SIX3
protein localization to nucleus (GO:0034504) 4.92SHH, SIX3
developmental process (GO:0032502) 1.362SHH, SIX3
positive regulation of cellular biosynthetic process (GO:0031328) 2.32SHH, SIX3
negative regulation of cellular biosynthetic process (GO:0031327) 2.492SHH, SIX3
regulation of cellular biosynthetic process (GO:0031326) 1.382SHH, SIX3
positive regulation of cellular metabolic process (GO:0031325) 1.812SHH, SIX3
negative regulation of cellular metabolic process (GO:0031324) 2.012SHH, SIX3
regulation of cellular metabolic process (GO:0031323) 1.072SHH, SIX3
multicellular organism development (GO:0007275) 2.542SHH, SIX3
pattern specification process (GO:0007389) 3.792SHH, SIX3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462SHH, SIX3
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62SHH, SIX3
negative regulation of Wnt signaling pathway (GO:0030178) 4.442SHH, SIX3
organic substance metabolic process (GO:0071704) 0.632SHH, SIX3
regulation of nervous system development (GO:0051960) 3.12SHH, SIX3
regulation of neuroblast proliferation (GO:1902692) 6.362SHH, SIX3
tissue morphogenesis (GO:0048729) 3.872SHH, SIX3
regulation of gene expression (GO:0010468) 1.372SHH, SIX3
telencephalon regionalization (GO:0021978) 7.782SHH, SIX3
embryonic morphogenesis (GO:0048598) 3.722SHH, SIX3
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352SHH, SIX3
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552SHH, SIX3
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432SHH, SIX3
cellular protein localization (GO:0034613) 3.112SHH, SIX3
single-organism developmental process (GO:0044767) 1.492SHH, SIX3
single-organism cellular process (GO:0044763) 0.652SHH, SIX3
regulation of nitrogen compound metabolic process (GO:0051171) 1.362SHH, SIX3
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472SHH, SIX3
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292SHH, SIX3
localization (GO:0051179) 1.42SHH, SIX3
cellular localization (GO:0051641) 2.322SHH, SIX3
locomotion (GO:0040011) 2.912SHH, SIX3
primary metabolic process (GO:0044238) 0.692SHH, SIX3
anatomical structure development (GO:0048856) 1.582SHH, SIX3
cellular metabolic process (GO:0044237) 0.692SHH, SIX3
regulation of multicellular organismal development (GO:2000026) 2.312SHH, SIX3
negative regulation of transcription, DNA-templated (GO:0045892) 2.752SHH, SIX3
negative regulation of cellular process (GO:0048523) 1.412SHH, SIX3
positive regulation of cellular process (GO:0048522) 1.32SHH, SIX3

NET-GE enrichment

Term New enriched termICP valueGenes
dorsal/ventral pattern formation (GO:0009953) -5.60.007SHH, SIX3
developmental induction (GO:0031128) NEW6.590.014SHH, SIX3
sensory organ development (GO:0007423) -4.820.018SHH, SIX3
cell-cell signaling involved in cell fate commitment (GO:0045168) NEW9.040.016SHH, SIX3
forebrain dorsal/ventral pattern formation (GO:0021798) NEW7.780.001SHH, SIX3
eye development (GO:0001654) -5.070.011SHH, SIX3
columnar/cuboidal epithelial cell development (GO:0002066) NEW6.290.013SHH, SIX3
negative regulation of Wnt signaling pathway (GO:0030178) -4.440.028SHH, SIX3
middle ear morphogenesis (GO:0042474) NEW6.730.015SHH, SIX3
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.282SHH, SIX3
cell part (GO:0044464) 0.112SHH, SIX3