Disease table of MICROPHTHALMIA, ISOLATED, WITH COLOBOMA OMIM ID: PS300345

Gene-disease associations table

GeneAssociated with MICROPHTHALMIA, ISOLATED, WITH COLOBOMA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
GDF3ClinVar, OMIM, HUMSAVARHGNC link12p13.314PS300345, PS118100, 120200, PS251600
STRA6ClinVar, OMIM, HUMSAVARHGNC link15q24.12PS309800, PS300345
GDF6ClinVar, OMIMHGNC link8q22.14PS300345, PS118100, PS204000, PS251600
TENM3ClinVar, OMIMHGNC link4q34.31PS300345
RBP4ClinVar, OMIM, HUMSAVARHGNC link10q23.332PS300345, 615147
ABCB6ClinVar, OMIM, HUMSAVARHGNC link2q354PS127500, 609153, 111600, PS300345
VSX2ClinVar, OMIM, HUMSAVARHGNC link14q24.32PS251600, PS300345
SHHOMIMHGNC link7q36.34PS300345, 269160, PS236100, 147250

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
GDF3YES1NANOG0
VSX2YES1NEUROG30
SHHYES3STAT3, PAX3, SOX90
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
STRA6RBP4Yesbinding1TTR
GDF6SHHNo-1NOG
ABCB6SHHNo-1UBC
VSX2SHHNo-1ASCL1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
DiseaseR-HSA-16436853.334STRA6, SHH, ABCB6, RBP4
Signal TransductionR-HSA-1625821.783STRA6, SHH, RBP4
Diseases of signal transductionR-HSA-56632024.893STRA6, SHH, RBP4
The canonical retinoid cycle in rods (twilight vision)R-HSA-24539028.522STRA6, RBP4
Retinoid cycle disease eventsR-HSA-24538649.282STRA6, RBP4
Visual phototransductionR-HSA-21873386.442STRA6, RBP4
Diseases associated with visual transductionR-HSA-24747959.282STRA6, RBP4

NET-GE enrichment

Term New enriched termICP valueGenes
Diseases associated with visual transduction (R-HSA-2474795) -9.280.0STRA6, RBP4
Visual phototransduction (R-HSA-2187338) -6.440.019STRA6, RBP4
Diseases of signal transduction (R-HSA-5663202) -4.890.004STRA6, SHH, RBP4
Retinoid cycle disease events (R-HSA-2453864) -9.280.0STRA6, RBP4
The canonical retinoid cycle in rods (twilight vision) (R-HSA-2453902) -8.520.018STRA6, RBP4
Disease (R-HSA-1643685) -3.330.002STRA6, SHH, ABCB6, RBP4
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.187GDF3, VSX2, RBP4, GDF6, TENM3, ABCB6, SHH
protein binding (GO:0005515) 0.465RBP4, TENM3, SHH, GDF3, GDF6
transporter activity (GO:0005215) 2.573STRA6, ABCB6, RBP4
receptor binding (GO:0005102) 2.433SHH, GDF6, GDF3
protein dimerization activity (GO:0046983) 2.723TENM3, GDF6, RBP4
cytokine receptor binding (GO:0005126) 4.142GDF6, GDF3
hydrolase activity (GO:0016787) 1.92SHH, ABCB6
cytokine activity (GO:0005125) 4.342GDF6, GDF3
growth factor activity (GO:0008083) 4.662GDF6, GDF3
vitamin transporter activity (GO:0051183) 6.562STRA6, RBP4
carbohydrate derivative binding (GO:0097367) 2.032SHH, ABCB6
organic cyclic compound binding (GO:0097159) 1.052ABCB6, VSX2
transforming growth factor beta receptor binding (GO:0005160) 5.812GDF6, GDF3
small molecule binding (GO:0036094) 1.892ABCB6, RBP4
catalytic activity (GO:0003824) 1.052SHH, ABCB6
protein heterodimerization activity (GO:0046982) 3.642TENM3, RBP4
heterocyclic compound binding (GO:1901363) 1.062ABCB6, VSX2
identical protein binding (GO:0042802) 2.632TENM3, GDF6
protein homodimerization activity (GO:0042803) 3.162TENM3, GDF6

NET-GE enrichment

Term New enriched termICP valueGenes
vitamin transporter activity (GO:0051183) -6.560.012STRA6, RBP4
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism developmental process (GO:0044767) 1.498STRA6, GDF3, VSX2, RBP4, GDF6, TENM3, ABCB6, SHH
developmental process (GO:0032502) 1.368STRA6, GDF3, VSX2, RBP4, GDF6, TENM3, ABCB6, SHH
cellular process (GO:0009987) 0.268STRA6, GDF3, VSX2, RBP4, GDF6, TENM3, ABCB6, SHH
biological regulation (GO:0065007) 0.398STRA6, GDF3, VSX2, RBP4, GDF6, TENM3, ABCB6, SHH
single-organism process (GO:0044699) 0.488STRA6, GDF3, VSX2, RBP4, GDF6, TENM3, ABCB6, SHH
organic substance metabolic process (GO:0071704) 0.637STRA6, VSX2, RBP4, GDF6, TENM3, ABCB6, SHH
anatomical structure development (GO:0048856) 1.587STRA6, GDF3, VSX2, RBP4, GDF6, SHH, ABCB6
single-organism cellular process (GO:0044763) 0.657STRA6, GDF3, RBP4, GDF6, TENM3, ABCB6, SHH
regulation of biological process (GO:0050789) 0.457STRA6, GDF3, VSX2, RBP4, GDF6, TENM3, SHH
metabolic process (GO:0008152) 0.587STRA6, VSX2, RBP4, GDF6, TENM3, ABCB6, SHH
positive regulation of biological process (GO:0048518) 1.26STRA6, GDF3, RBP4, GDF6, TENM3, SHH
primary metabolic process (GO:0044238) 0.696STRA6, VSX2, RBP4, GDF6, TENM3, SHH
multicellular organismal process (GO:0032501) 1.456STRA6, GDF3, VSX2, RBP4, GDF6, SHH
cellular metabolic process (GO:0044237) 0.696STRA6, VSX2, RBP4, GDF6, SHH, ABCB6
regulation of cellular process (GO:0050794) 0.56GDF3, VSX2, RBP4, GDF6, TENM3, SHH
single-multicellular organism process (GO:0044707) 1.785STRA6, VSX2, SHH, GDF6, GDF3
regulation of developmental process (GO:0050793) 2.15RBP4, TENM3, SHH, GDF3, GDF6
animal organ development (GO:0048513) 2.535STRA6, SHH, ABCB6, RBP4, GDF3
regulation of multicellular organismal development (GO:2000026) 2.315RBP4, TENM3, SHH, GDF3, GDF6
regulation of multicellular organismal process (GO:0051239) 1.875TENM3, SHH, RBP4, GDF3, GDF6
positive regulation of cellular process (GO:0048522) 1.35RBP4, TENM3, SHH, GDF3, GDF6
regulation of primary metabolic process (GO:0080090) 1.084VSX2, SHH, GDF6, GDF3
regulation of metabolic process (GO:0019222) 1.024VSX2, SHH, GDF6, GDF3
regulation of cellular biosynthetic process (GO:0031326) 1.384VSX2, SHH, GDF6, GDF3
regulation of cellular metabolic process (GO:0031323) 1.074VSX2, SHH, GDF6, GDF3
positive regulation of signaling (GO:0023056) 2.414SHH, RBP4, GDF3, GDF6
signal transduction (GO:0007165) 1.284TENM3, SHH, GDF3, GDF6
regulation of signaling (GO:0023051) 1.724SHH, RBP4, GDF3, GDF6
positive regulation of cell communication (GO:0010647) 2.414SHH, RBP4, GDF3, GDF6
regulation of cell communication (GO:0010646) 1.734SHH, RBP4, GDF3, GDF6
multicellular organism development (GO:0007275) 2.544VSX2, SHH, GDF6, GDF3
anatomical structure morphogenesis (GO:0009653) 2.534STRA6, TENM3, SHH, RBP4
growth (GO:0040007) 3.84STRA6, SHH, GDF6, GDF3
cellular developmental process (GO:0048869) 1.824TENM3, SHH, GDF6, GDF3
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.464VSX2, SHH, GDF6, GDF3
regulation of macromolecule metabolic process (GO:0060255) 1.084VSX2, SHH, GDF6, GDF3
regulation of gene expression (GO:0010468) 1.374VSX2, SHH, GDF6, GDF3
anatomical structure formation involved in morphogenesis (GO:0048646) 3.014STRA6, SHH, RBP4, GDF3
organ morphogenesis (GO:0009887) 3.554STRA6, TENM3, SHH, RBP4
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.434VSX2, SHH, GDF6, GDF3
transport (GO:0006810) 1.514STRA6, SHH, ABCB6, RBP4
regulation of biosynthetic process (GO:0009889) 1.374VSX2, SHH, GDF6, GDF3
tissue development (GO:0009888) 3.274STRA6, SHH, RBP4, GDF3
regulation of nucleic acid-templated transcription (GO:1903506) 1.554VSX2, SHH, GDF6, GDF3
regulation of cell differentiation (GO:0045595) 2.424SHH, TENM3, GDF3, GDF6
regulation of nitrogen compound metabolic process (GO:0051171) 1.364VSX2, SHH, GDF6, GDF3
regulation of RNA biosynthetic process (GO:2001141) 1.554VSX2, SHH, GDF6, GDF3
establishment of localization (GO:0051234) 1.484STRA6, SHH, ABCB6, RBP4
localization (GO:0051179) 1.44STRA6, SHH, ABCB6, RBP4
sensory organ development (GO:0007423) 4.824STRA6, SHH, RBP4, GDF3
response to stimulus (GO:0050896) 1.224VSX2, SHH, RBP4, GDF3
regulation of RNA metabolic process (GO:0051252) 1.524VSX2, SHH, GDF6, GDF3
macromolecule metabolic process (GO:0043170) 0.834VSX2, TENM3, SHH, GDF6
regulation of transcription, DNA-templated (GO:0006355) 1.564VSX2, SHH, GDF6, GDF3
regulation of macromolecule biosynthetic process (GO:0010556) 1.434VSX2, SHH, GDF6, GDF3
system development (GO:0048731) 2.924STRA6, SHH, RBP4, GDF3
lung development (GO:0030324) 5.133STRA6, SHH, RBP4
positive regulation of metabolic process (GO:0009893) 1.743SHH, GDF6, GDF3
embryonic organ development (GO:0048568) 4.863STRA6, SHH, GDF3
positive regulation of cellular metabolic process (GO:0031325) 1.813SHH, GDF6, GDF3
positive regulation of response to stimulus (GO:0048584) 2.183SHH, GDF6, GDF3
regulation of response to stimulus (GO:0048583) 1.543SHH, GDF6, GDF3
skeletal system development (GO:0001501) 4.493SHH, RBP4, GDF3
regulation of cell death (GO:0010941) 2.433SHH, GDF6, GDF3
regulation of apoptotic process (GO:0042981) 2.53SHH, GDF6, GDF3
regulation of neurogenesis (GO:0050767) 3.213TENM3, SHH, GDF6
positive regulation of macromolecule metabolic process (GO:0010604) 1.813SHH, GDF6, GDF3
regulation of signal transduction (GO:0009966) 1.843SHH, GDF6, GDF3
positive regulation of signal transduction (GO:0009967) 2.53SHH, GDF6, GDF3
positive regulation of multicellular organismal process (GO:0051240) 2.493TENM3, SHH, GDF6
regulation of protein metabolic process (GO:0051246) 1.933SHH, GDF6, GDF3
regulation of cell development (GO:0060284) 3.013TENM3, SHH, GDF6
positive regulation of neurogenesis (GO:0050769) 3.773SHH, TENM3, GDF6
regulation of neuron differentiation (GO:0045664) 3.393SHH, TENM3, GDF6
regulation of programmed cell death (GO:0043067) 2.493SHH, GDF6, GDF3
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243SHH, GDF6, GDF3
genitalia development (GO:0048806) 6.23STRA6, SHH, RBP4
positive regulation of cell development (GO:0010720) 3.573TENM3, SHH, GDF6
negative regulation of biological process (GO:0048519) 1.333SHH, RBP4, GDF3
regulation of biological quality (GO:0065008) 1.683SHH, ABCB6, RBP4
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.393SHH, GDF6, GDF3
cell differentiation (GO:0030154) 2.143TENM3, SHH, GDF6
reproductive structure development (GO:0048608) 4.083STRA6, SHH, RBP4
organic substance biosynthetic process (GO:1901576) 1.343ABCB6, VSX2, RBP4
neurological system process (GO:0050877) 2.643STRA6, VSX2, RBP4
cell development (GO:0048468) 3.283SHH, GDF6, GDF3
positive regulation of cell differentiation (GO:0045597) 3.013SHH, TENM3, GDF6
developmental process involved in reproduction (GO:0003006) 3.363STRA6, SHH, RBP4
single-organism transport (GO:0044765) 2.183STRA6, ABCB6, RBP4
single organism reproductive process (GO:0044702) 2.733STRA6, SHH, RBP4
eye development (GO:0001654) 5.073SHH, RBP4, GDF3
single-organism localization (GO:1902578) 2.093STRA6, ABCB6, RBP4
system process (GO:0003008) 2.33STRA6, VSX2, RBP4
negative regulation of developmental process (GO:0051093) 3.173SHH, RBP4, GDF3
heart development (GO:0007507) 4.243STRA6, SHH, RBP4
regulation of cellular protein metabolic process (GO:0032268) 1.993SHH, GDF6, GDF3
reproductive process (GO:0022414) 2.553STRA6, SHH, RBP4
protein metabolic process (GO:0019538) 1.453SHH, TENM3, GDF6
positive regulation of developmental process (GO:0051094) 2.773SHH, TENM3, GDF6
biosynthetic process (GO:0009058) 1.323ABCB6, VSX2, RBP4
positive regulation of nervous system development (GO:0051962) 3.643TENM3, SHH, GDF6
regulation of nervous system development (GO:0051960) 3.13TENM3, SHH, GDF6
muscle tissue development (GO:0060537) 5.13STRA6, SHH, RBP4
negative regulation of cellular process (GO:0048523) 1.413SHH, RBP4, GDF3
regulation of phosphate metabolic process (GO:0019220) 2.352GDF6, GDF3
developmental growth (GO:0048589) 4.052STRA6, SHH
regulation of transport (GO:0051049) 2.242SHH, RBP4
negative regulation of response to stimulus (GO:0048585) 2.522SHH, GDF3
cell surface receptor signaling pathway (GO:0007166) 2.092SHH, GDF6
organic cyclic compound biosynthetic process (GO:1901362) 1.662ABCB6, VSX2
organic cyclic compound metabolic process (GO:1901360) 1.262ABCB6, VSX2
hormone metabolic process (GO:0042445) 4.642SHH, RBP4
single-organism metabolic process (GO:0044710) 1.632STRA6, RBP4
negative regulation of signal transduction (GO:0009968) 2.752SHH, GDF3
kidney development (GO:0001822) 4.792STRA6, SHH
positive regulation of neuron differentiation (GO:0045666) 3.982TENM3, GDF6
diterpenoid metabolic process (GO:0016101) 5.172STRA6, RBP4
regulation of cell proliferation (GO:0042127) 2.412SHH, RBP4
regulation of striated muscle tissue development (GO:0016202) 5.092SHH, RBP4
positive regulation of transport (GO:0051050) 2.92SHH, RBP4
visual perception (GO:0007601) 4.412VSX2, RBP4
sensory perception (GO:0007600) 2.932VSX2, RBP4
heterocycle metabolic process (GO:0046483) 1.312ABCB6, VSX2
regulation of phosphorylation (GO:0042325) 2.52GDF6, GDF3
positive regulation of phosphorylation (GO:0042327) 2.92GDF6, GDF3
embryo development (GO:0009790) 4.22SHH, GDF3
SMAD protein signal transduction (GO:0060395) 5.652GDF6, GDF3
regulation of pathway-restricted SMAD protein phosphorylation (GO:0060393) 5.632GDF6, GDF3
aromatic compound biosynthetic process (GO:0019438) 1.72ABCB6, VSX2
chemical homeostasis (GO:0048878) 2.972ABCB6, RBP4
embryonic organ morphogenesis (GO:0048562) 4.922SHH, RBP4
positive regulation of biosynthetic process (GO:0009891) 2.292SHH, GDF6
nitrogen compound metabolic process (GO:0006807) 1.132ABCB6, VSX2
positive regulation of protein transport (GO:0051222) 3.612SHH, RBP4
positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862) 5.862GDF6, GDF3
embryonic pattern specification (GO:0009880) 5.82SHH, GDF3
cellular macromolecule metabolic process (GO:0044260) 0.932VSX2, GDF6
blood vessel development (GO:0001568) 4.952STRA6, SHH
positive regulation of immune system process (GO:0002684) 2.962SHH, RBP4
regulation of immune system process (GO:0002682) 2.52SHH, RBP4
regulation of MAPK cascade (GO:0043408) 3.222GDF6, GDF3
heterocycle biosynthetic process (GO:0018130) 1.72ABCB6, VSX2
regulation of muscle tissue development (GO:1901861) 5.072SHH, RBP4
regulation of establishment of protein localization (GO:0070201) 3.022SHH, RBP4
negative regulation of muscle tissue development (GO:1901862) 6.172SHH, RBP4
lipid metabolic process (GO:0006629) 2.682STRA6, RBP4
cell-cell adhesion (GO:0098609) 3.342TENM3, SHH
sensory perception of light stimulus (GO:0050953) 4.42VSX2, RBP4
regulation of intracellular signal transduction (GO:1902531) 2.312GDF6, GDF3
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592ABCB6, VSX2
embryonic skeletal system development (GO:0048706) 5.972SHH, RBP4
positive regulation of protein modification process (GO:0031401) 2.72GDF6, GDF3
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392SHH, GDF6
female genitalia development (GO:0030540) 7.092STRA6, RBP4
regulation of muscle organ development (GO:0048634) 5.072SHH, RBP4
negative regulation of signaling (GO:0023057) 2.652SHH, GDF3
cellular nitrogen compound metabolic process (GO:0034641) 1.222ABCB6, VSX2
negative regulation of cell communication (GO:0010648) 2.662SHH, GDF3
positive regulation of establishment of protein localization (GO:1904951) 3.492SHH, RBP4
regulation of protein localization (GO:0032880) 2.882SHH, RBP4
positive regulation of phosphorus metabolic process (GO:0010562) 2.782GDF6, GDF3
negative regulation of multicellular organismal process (GO:0051241) 2.842SHH, RBP4
vasculature development (GO:0001944) 6.042STRA6, SHH
positive regulation of protein metabolic process (GO:0051247) 2.432GDF6, GDF3
positive regulation of cellular protein metabolic process (GO:0032270) 2.492GDF6, GDF3
regulation of protein modification process (GO:0031399) 2.322GDF6, GDF3
proteolysis (GO:0006508) 2.732TENM3, SHH
biological adhesion (GO:0022610) 2.812TENM3, SHH
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562SHH, GDF6
negative regulation of cell proliferation (GO:0008285) 3.262SHH, RBP4
tube morphogenesis (GO:0035239) 4.352STRA6, SHH
terpenoid metabolic process (GO:0006721) 5.072STRA6, RBP4
isoprenoid metabolic process (GO:0006720) 4.892STRA6, RBP4
lung epithelium development (GO:0060428) 7.332STRA6, SHH
epithelium development (GO:0060429) 4.572STRA6, SHH
cellular aromatic compound metabolic process (GO:0006725) 1.32ABCB6, VSX2
negative regulation of cell differentiation (GO:0045596) 3.332SHH, GDF3
positive regulation of transcription, DNA-templated (GO:0045893) 2.562SHH, GDF6
cellular lipid metabolic process (GO:0044255) 2.922STRA6, RBP4
regulation of localization (GO:0032879) 1.942SHH, RBP4
positive regulation of RNA metabolic process (GO:0051254) 2.512SHH, GDF6
positive regulation of RNA biosynthetic process (GO:1902680) 2.542SHH, GDF6
positive regulation of gene expression (GO:0010628) 2.352SHH, GDF6
gland development (GO:0048732) 4.152STRA6, SHH
digestive tract morphogenesis (GO:0048546) 6.782STRA6, SHH
positive regulation of cellular biosynthetic process (GO:0031328) 2.32SHH, GDF6
homeostatic process (GO:0042592) 2.612ABCB6, RBP4
striated muscle tissue development (GO:0014706) 5.232SHH, RBP4
regulation of muscle cell differentiation (GO:0051147) 4.682SHH, GDF3
negative regulation of muscle cell differentiation (GO:0051148) 5.72SHH, GDF3
retinoid metabolic process (GO:0001523) 5.252STRA6, RBP4
pattern specification process (GO:0007389) 3.792SHH, GDF3
regulation of protein transport (GO:0051223) 3.122SHH, RBP4
organic substance transport (GO:0071702) 2.152ABCB6, RBP4
skin development (GO:0043588) 5.842SHH, ABCB6
sensory organ morphogenesis (GO:0090596) 5.722STRA6, TENM3
embryonic morphogenesis (GO:0048598) 3.722SHH, RBP4
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352SHH, GDF6
positive regulation of phosphate metabolic process (GO:0045937) 2.782GDF6, GDF3
regulation of hormone levels (GO:0010817) 3.562SHH, RBP4
regulation of phosphorus metabolic process (GO:0051174) 2.352GDF6, GDF3
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292SHH, GDF6
cell adhesion (GO:0007155) 2.822SHH, TENM3
response to chemical (GO:0042221) 1.982SHH, RBP4
tube development (GO:0035295) 4.412STRA6, SHH
cellular hormone metabolic process (GO:0034754) 5.092SHH, RBP4
formation of anatomical boundary (GO:0048859) 8.122SHH, GDF3
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) 5.122GDF6, GDF3
regulation of protein phosphorylation (GO:0001932) 2.572GDF6, GDF3
cellular biosynthetic process (GO:0044249) 1.372ABCB6, VSX2
positive regulation of protein phosphorylation (GO:0001934) 2.952GDF6, GDF3

NET-GE enrichment

Term New enriched termICP valueGenes
lung development (GO:0030324) -5.130.004STRA6, SHH, RBP4
observational learning (GO:0098597) NEW7.650.015STRA6, RBP4
imitative learning (GO:0098596) NEW7.780.015STRA6, RBP4
vasculature development (GO:0001944) -6.040.018STRA6, SHH, RBP4
vocal learning (GO:0042297) NEW7.780.015STRA6, RBP4
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) -4.390.046SHH, GDF6, GDF3
skeletal system development (GO:0001501) -4.490.031SHH, RBP4, GDF3
head morphogenesis (GO:0060323) NEW7.650.021STRA6, RBP4
face morphogenesis (GO:0060325) NEW6.290.01STRA6, SHH, RBP4
embryonic organ development (GO:0048568) -4.860.026STRA6, SHH, RBP4, GDF3
nose morphogenesis (GO:0043585) NEW8.630.004STRA6, RBP4
hormone metabolic process (GO:0042445) -4.640.03STRA6, SHH, RBP4
growth (GO:0040007) -3.80.006STRA6, SHH, GDF6, GDF3
embryonic digestive tract development (GO:0048566) NEW6.780.002STRA6, SHH, RBP4
female genitalia development (GO:0030540) -7.090.013STRA6, RBP4
vitamin transmembrane transport (GO:0035461) NEW7.650.025STRA6, RBP4
organ development (GO:0048513) -2.530.038STRA6, SHH, ABCB6, RBP4, GDF3
genitalia development (GO:0048806) -6.20.014STRA6, SHH, RBP4
ear development (GO:0043583) NEW7.240.025STRA6, RBP4
learned vocalization behavior or vocal learning (GO:0098598) NEW7.780.015STRA6, RBP4
organ morphogenesis (GO:0009887) -3.550.013STRA6, SHH, TENM3, RBP4
positive regulation of JAK-STAT cascade (GO:0046427) NEW5.440.03STRA6, SHH, RBP4
embryonic camera-type eye formation (GO:0060900) NEW9.040.003STRA6, RBP4
lung epithelium development (GO:0060428) -7.330.0STRA6, SHH, RBP4
eye development (GO:0001654) -5.070.004SHH, RBP4, GDF3
retinol transport (GO:0034633) NEW9.730.0STRA6, RBP4
cellular hormone metabolic process (GO:0034754) -5.090.006STRA6, SHH, RBP4
uterus morphogenesis (GO:0061038) NEW8.120.008STRA6, RBP4
pulmonary artery morphogenesis (GO:0061156) NEW8.120.015STRA6, RBP4
heart development (GO:0007507) -4.240.034STRA6, SHH, RBP4
formation of anatomical boundary (GO:0048859) -8.120.015SHH, GDF3
sensory organ development (GO:0007423) -4.820.014STRA6, SHH, RBP4, GDF3
ductus arteriosus closure (GO:0097070) NEW7.940.025STRA6, RBP4
pulmonary valve morphogenesis (GO:0003184) NEW7.780.021STRA6, RBP4
muscle tissue development (GO:0060537) -5.10.007STRA6, SHH, RBP4
paramesonephric duct development (GO:0061205) NEW8.630.012STRA6, RBP4
digestive tract morphogenesis (GO:0048546) -6.780.002STRA6, SHH, RBP4
isoprenoid transport (GO:0046864) NEW9.730.0STRA6, RBP4
terpenoid transport (GO:0046865) NEW9.730.0STRA6, RBP4
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.117STRA6, VSX2, RBP4, GDF3, TENM3, ABCB6, SHH
intracellular part (GO:0044424) 0.285VSX2, SHH, ABCB6, RBP4, GDF3
extracellular region part (GO:0044421) 1.575SHH, ABCB6, RBP4, GDF3, GDF6
membrane part (GO:0044425) 0.954STRA6, SHH, ABCB6, TENM3
membrane (GO:0016020) 0.684STRA6, SHH, ABCB6, TENM3
extracellular space (GO:0005615) 2.634SHH, RBP4, GDF3, GDF6
extracellular region (GO:0005576) 2.184SHH, RBP4, GDF3, GDF6
protein complex (GO:0043234) 1.513STRA6, ABCB6, RBP4
macromolecular complex (GO:0032991) 1.353STRA6, ABCB6, RBP4
integral component of membrane (GO:0016021) 1.143STRA6, TENM3, ABCB6
cytoplasmic part (GO:0044444) 0.823SHH, ABCB6, RBP4
plasma membrane (GO:0005886) 1.393STRA6, SHH, ABCB6
membrane-bounded organelle (GO:0043227) 0.473ABCB6, VSX2, RBP4
organelle (GO:0043226) 0.43ABCB6, VSX2, RBP4
intrinsic component of membrane (GO:0031224) 1.133STRA6, TENM3, ABCB6
extracellular organelle (GO:0043230) 1.892ABCB6, RBP4
intracellular membrane-bounded organelle (GO:0043231) 0.62ABCB6, VSX2
cytosol (GO:0005829) 1.682SHH, RBP4
vesicle (GO:0031982) 1.642ABCB6, RBP4
membrane-bounded vesicle (GO:0031988) 1.712ABCB6, RBP4
intracellular organelle part (GO:0044446) 0.812SHH, ABCB6
endoplasmic reticulum part (GO:0044432) 2.732SHH, ABCB6
intracellular organelle (GO:0043229) 0.512ABCB6, VSX2
extracellular vesicle (GO:1903561) 1.892ABCB6, RBP4
organelle part (GO:0044422) 0.792SHH, ABCB6
extracellular exosome (GO:0070062) 1.892ABCB6, RBP4

NET-GE enrichment

Term New enriched termICP valueGenes
extracellular space (GO:0005615) -2.630.045SHH, RBP4, GDF3, GDF6