Disease table of SMOKING AS A QUANTITATIVE TRAIT LOCUS 3 OMIM ID: 612052

Gene-disease associations table

GeneAssociated with SMOKING AS A QUANTITATIVE TRAIT LOCUS 3 inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
CHRNA5ClinVar, OMIMHGNC link15q25.11612052
CHRNA3ClinVar, OMIMHGNC link15q25.11612052

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Common tandem groupNumber of genes in this tandem group associated to this diseaseGenes in this tandem group associated to this disease
Group 6762CHRNA5, CHRNA3
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
15q25.12CHRNA5, CHRNA3
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
15q252CHRNA5, CHRNA3
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
15q22CHRNA5, CHRNA3
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
15q2CHRNA5, CHRNA3
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
152CHRNA5, CHRNA3
Transcription Factors (TF) annotation from TRRUST
TFassociated to this disease# regulated genesRegulated genes# regulated genes associated with this diseaseRegulated genes associated with this disease
ASCL1NO7TPH1, CHRNA3, PCSK6, CHRNA5, CHRNB4, IGF2, DKK12CHRNA3, CHRNA5
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CHRNA5YES1ASCL10
CHRNA3YES1ASCL10
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
CHRNA5CHRNA3Yesbinding10CHRNA4, CHRNB2, CHRNA2, CHRNB3, CHRNB1, CHRNA6, CHRNB4, CHRNA7, CHRND, CHRNE

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
CHRNA3CHRNA5yes, maybe indirectThe neuronal subtypes of Cholinergic Receptor Nicotinic are various homomeric or heteromeric combinations of twelve different nicotinic receptor subunits: A2-A10 and B2-B4. Examples of the neuronal subtypes include: (A4)3(B2)2, (A4)2(B2)3, and (A7)5.
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Neuroactive ligand-receptor interactionhsa040804.582CHRNA3, CHRNA5

NET-GE enrichment

Term New enriched termICP valueGenes
Neuroactive ligand-receptor interaction (hsa04080) -4.580.028CHRNA3, CHRNA5
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Acetylcholine Binding And Downstream EventsR-HSA-1814319.182CHRNA3, CHRNA5
Activation of Nicotinic Acetylcholine ReceptorsR-HSA-6296029.182CHRNA3, CHRNA5
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-6295979.812CHRNA3, CHRNA5
Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsR-HSA-6295949.522CHRNA3, CHRNA5
Postsynaptic nicotinic acetylcholine receptorsR-HSA-6223279.182CHRNA3, CHRNA5
Presynaptic nicotinic acetylcholine receptorsR-HSA-6223239.42CHRNA3, CHRNA5
Neuronal SystemR-HSA-1123164.822CHRNA3, CHRNA5
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellR-HSA-1123145.852CHRNA3, CHRNA5
Transmission across Chemical SynapsesR-HSA-1123155.282CHRNA3, CHRNA5

NET-GE enrichment

Term New enriched termICP valueGenes
Acetylcholine Binding And Downstream Events (R-HSA-181431) -9.180.0CHRNA3, CHRNA5
Activation of Nicotinic Acetylcholine Receptors (R-HSA-629602) -9.180.0CHRNA3, CHRNA5
Highly calcium permeable nicotinic acetylcholine receptors (R-HSA-629597) -9.810.0CHRNA3, CHRNA5
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors (R-HSA-629594) -9.520.0CHRNA3, CHRNA5
Postsynaptic nicotinic acetylcholine receptors (R-HSA-622327) -9.180.0CHRNA3, CHRNA5
Presynaptic nicotinic acetylcholine receptors (R-HSA-622323) -9.40.0CHRNA3, CHRNA5
Neuronal System (R-HSA-112316) -4.820.033CHRNA3, CHRNA5
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell (R-HSA-112314) -5.850.006CHRNA3, CHRNA5
Transmission across Chemical Synapses (R-HSA-112315) -5.280.007CHRNA3, CHRNA5
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
signaling receptor activity (GO:0038023) 2.492CHRNA3, CHRNA5
acetylcholine receptor activity (GO:0015464) 6.32CHRNA3, CHRNA5
molecular transducer activity (GO:0060089) 2.322CHRNA3, CHRNA5
receptor activity (GO:0004872) 2.322CHRNA3, CHRNA5
signal transducer activity (GO:0004871) 2.282CHRNA3, CHRNA5
cation channel activity (GO:0005261) 4.042CHRNA3, CHRNA5
cation binding (GO:0043169) 1.42CHRNA3, CHRNA5
ligand-gated ion channel activity (GO:0015276) 4.82CHRNA3, CHRNA5
ion binding (GO:0043167) 1.362CHRNA3, CHRNA5
transmembrane transporter activity (GO:0022857) 2.822CHRNA3, CHRNA5
acetylcholine-activated cation-selective channel activity (GO:0004889) 6.652CHRNA3, CHRNA5
passive transmembrane transporter activity (GO:0022803) 3.62CHRNA3, CHRNA5
extracellular ligand-gated ion channel activity (GO:0005230) 5.422CHRNA3, CHRNA5
neurotransmitter receptor activity (GO:0030594) 5.52CHRNA3, CHRNA5
protein heterodimerization activity (GO:0046982) 3.642CHRNA3, CHRNA5
transporter activity (GO:0005215) 2.572CHRNA3, CHRNA5
ion channel activity (GO:0005216) 3.712CHRNA3, CHRNA5
excitatory extracellular ligand-gated ion channel activity (GO:0005231) 5.732CHRNA3, CHRNA5
acetylcholine binding (GO:0042166) 6.562CHRNA3, CHRNA5
neurotransmitter binding (GO:0042165) 6.342CHRNA3, CHRNA5
cation transmembrane transporter activity (GO:0008324) 3.322CHRNA3, CHRNA5
substrate-specific transmembrane transporter activity (GO:0022891) 2.92CHRNA3, CHRNA5
substrate-specific transporter activity (GO:0022892) 2.722CHRNA3, CHRNA5
ion transmembrane transporter activity (GO:0015075) 3.042CHRNA3, CHRNA5
ammonium ion binding (GO:0070405) 5.812CHRNA3, CHRNA5
transmembrane signaling receptor activity (GO:0004888) 2.572CHRNA3, CHRNA5
channel activity (GO:0015267) 3.62CHRNA3, CHRNA5
gated channel activity (GO:0022836) 3.962CHRNA3, CHRNA5
protein binding (GO:0005515) 0.462CHRNA3, CHRNA5
ligand-gated channel activity (GO:0022834) 4.82CHRNA3, CHRNA5
protein dimerization activity (GO:0046983) 2.722CHRNA3, CHRNA5
substrate-specific channel activity (GO:0022838) 3.672CHRNA3, CHRNA5
transmembrane receptor activity (GO:0099600) 2.532CHRNA3, CHRNA5
binding (GO:0005488) 0.182CHRNA3, CHRNA5

NET-GE enrichment

Term New enriched termICP valueGenes
calcium ion transmembrane transporter activity (GO:0015085) NEW4.890.007CHRNA3, CHRNA5
neurotransmitter receptor activity (GO:0030594) -5.50.002CHRNA3, CHRNA5
cation channel activity (GO:0005261) -4.040.008CHRNA3, CHRNA5
calcium channel activity (GO:0005262) NEW5.030.005CHRNA3, CHRNA5
substrate-specific channel activity (GO:0022838) -3.670.018CHRNA3, CHRNA5
extracellular ligand-gated ion channel activity (GO:0005230) -5.420.001CHRNA3, CHRNA5
excitatory extracellular ligand-gated ion channel activity (GO:0005231) -5.730.0CHRNA3, CHRNA5
ligand-gated ion channel activity (GO:0015276) -4.80.015CHRNA3, CHRNA5
acetylcholine receptor activity (GO:0015464) -6.30.0CHRNA3, CHRNA5
divalent inorganic cation transmembrane transporter activity (GO:0072509) NEW4.620.012CHRNA3, CHRNA5
channel activity (GO:0015267) -3.60.019CHRNA3, CHRNA5
acetylcholine-activated cation-selective channel activity (GO:0004889) -6.650.0CHRNA3, CHRNA5
neurotransmitter binding (GO:0042165) -6.340.0CHRNA3, CHRNA5
ligand-gated channel activity (GO:0022834) -4.80.015CHRNA3, CHRNA5
passive transmembrane transporter activity (GO:0022803) -3.60.019CHRNA3, CHRNA5
cation transmembrane transporter activity (GO:0008324) -3.320.04CHRNA3, CHRNA5
drug binding (GO:0008144) NEW5.030.01CHRNA3, CHRNA5
ion channel activity (GO:0005216) -3.710.017CHRNA3, CHRNA5
gated channel activity (GO:0022836) -3.960.011CHRNA3, CHRNA5
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to stimulus (GO:0050896) 1.222CHRNA3, CHRNA5
behavior (GO:0007610) 3.472CHRNA3, CHRNA5
signaling (GO:0023052) 3.252CHRNA3, CHRNA5
signal transduction (GO:0007165) 1.282CHRNA3, CHRNA5
response to alkaloid (GO:0043279) 4.832CHRNA3, CHRNA5
synaptic transmission, cholinergic (GO:0007271) 6.22CHRNA3, CHRNA5
localization (GO:0051179) 1.42CHRNA3, CHRNA5
neuromuscular synaptic transmission (GO:0007274) 6.432CHRNA3, CHRNA5
regulation of biological process (GO:0050789) 0.452CHRNA3, CHRNA5
response to organic cyclic compound (GO:0014070) 3.072CHRNA3, CHRNA5
response to endogenous stimulus (GO:0009719) 2.792CHRNA3, CHRNA5
transmembrane transport (GO:0055085) 2.722CHRNA3, CHRNA5
biological regulation (GO:0065007) 0.392CHRNA3, CHRNA5
single-organism process (GO:0044699) 0.482CHRNA3, CHRNA5
multicellular organismal process (GO:0032501) 1.452CHRNA3, CHRNA5
adult behavior (GO:0030534) 4.792CHRNA3, CHRNA5
cation transport (GO:0006812) 3.112CHRNA3, CHRNA5
ion transport (GO:0006811) 2.662CHRNA3, CHRNA5
transport (GO:0006810) 1.512CHRNA3, CHRNA5
regulation of cellular process (GO:0050794) 0.52CHRNA3, CHRNA5
ion transmembrane transport (GO:0034220) 3.082CHRNA3, CHRNA5
response to chemical (GO:0042221) 1.982CHRNA3, CHRNA5
single-organism cellular process (GO:0044763) 0.652CHRNA3, CHRNA5
chemical synaptic transmission (GO:0007268) 3.982CHRNA3, CHRNA5
cell-cell signaling (GO:0007267) 3.352CHRNA3, CHRNA5
cell communication (GO:0007154) 3.042CHRNA3, CHRNA5
establishment of localization (GO:0051234) 1.482CHRNA3, CHRNA5
response to organic substance (GO:0010033) 2.22CHRNA3, CHRNA5
single organism signaling (GO:0044700) 3.252CHRNA3, CHRNA5
single-multicellular organism process (GO:0044707) 1.782CHRNA3, CHRNA5
single-organism behavior (GO:0044708) 3.792CHRNA3, CHRNA5
response to nitrogen compound (GO:1901698) 3.122CHRNA3, CHRNA5
behavioral response to nicotine (GO:0035095) 7.782CHRNA3, CHRNA5
response to nicotine (GO:0035094) 5.782CHRNA3, CHRNA5
anterograde trans-synaptic signaling (GO:0098916) 3.982CHRNA3, CHRNA5
cellular process (GO:0009987) 0.262CHRNA3, CHRNA5
cation transmembrane transport (GO:0098655) 3.432CHRNA3, CHRNA5
response to organonitrogen compound (GO:0010243) 3.22CHRNA3, CHRNA5
synaptic signaling (GO:0099536) 3.982CHRNA3, CHRNA5
trans-synaptic signaling (GO:0099537) 3.982CHRNA3, CHRNA5

NET-GE enrichment

Term New enriched termICP valueGenes
muscle cell development (GO:0055001) NEW5.290.032CHRNA3, CHRNA5
musculoskeletal movement (GO:0050881) NEW7.240.0CHRNA3, CHRNA5
inner ear morphogenesis (GO:0042472) NEW5.620.021CHRNA3, CHRNA5
neuromuscular process (GO:0050905) NEW5.270.037CHRNA3, CHRNA5
single-organism behavior (GO:0044708) -3.790.049CHRNA3, CHRNA5
adult behavior (GO:0030534) -4.790.007CHRNA3, CHRNA5
detection of mechanical stimulus (GO:0050982) NEW5.940.003CHRNA3, CHRNA5
behavioral response to nicotine (GO:0035095) -7.780.0CHRNA3, CHRNA5
multicellular organismal movement (GO:0050879) NEW7.240.0CHRNA3, CHRNA5
calcium ion transmembrane transport (GO:0070588) NEW4.670.035CHRNA3, CHRNA5
striated muscle cell development (GO:0055002) NEW5.420.023CHRNA3, CHRNA5
muscle fiber development (GO:0048747) NEW5.80.006CHRNA3, CHRNA5
response to nicotine (GO:0035094) -5.780.001CHRNA3, CHRNA5
response to alkaloid (GO:0043279) -4.830.004CHRNA3, CHRNA5
synaptic transmission, cholinergic (GO:0007271) -6.20.0CHRNA3, CHRNA5
neuromuscular synaptic transmission (GO:0007274) -6.430.001CHRNA3, CHRNA5
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
plasma membrane region (GO:0098590) 2.972CHRNA3, CHRNA5
dendrite (GO:0030425) 3.922CHRNA3, CHRNA5
acetylcholine-gated channel complex (GO:0005892) 6.672CHRNA3, CHRNA5
ion channel complex (GO:0034702) 4.182CHRNA3, CHRNA5
synapse (GO:0045202) 3.582CHRNA3, CHRNA5
intrinsic component of membrane (GO:0031224) 1.132CHRNA3, CHRNA5
synaptic membrane (GO:0097060) 4.222CHRNA3, CHRNA5
integral component of membrane (GO:0016021) 1.142CHRNA3, CHRNA5
membrane (GO:0016020) 0.682CHRNA3, CHRNA5
plasma membrane receptor complex (GO:0098802) 4.632CHRNA3, CHRNA5
neuron part (GO:0097458) 2.642CHRNA3, CHRNA5
synapse part (GO:0044456) 3.422CHRNA3, CHRNA5
cell junction (GO:0030054) 2.752CHRNA3, CHRNA5
neuron projection (GO:0043005) 3.122CHRNA3, CHRNA5
neuronal cell body (GO:0043025) 3.92CHRNA3, CHRNA5
transmembrane transporter complex (GO:1902495) 4.062CHRNA3, CHRNA5
cell body (GO:0044297) 3.742CHRNA3, CHRNA5
transporter complex (GO:1990351) 4.042CHRNA3, CHRNA5
postsynaptic membrane (GO:0045211) 4.472CHRNA3, CHRNA5
plasma membrane (GO:0005886) 1.392CHRNA3, CHRNA5
cell projection (GO:0042995) 2.472CHRNA3, CHRNA5
protein complex (GO:0043234) 1.512CHRNA3, CHRNA5
receptor complex (GO:0043235) 4.012CHRNA3, CHRNA5
macromolecular complex (GO:0032991) 1.352CHRNA3, CHRNA5
plasma membrane part (GO:0044459) 1.952CHRNA3, CHRNA5
cell part (GO:0044464) 0.112CHRNA3, CHRNA5
plasma membrane protein complex (GO:0098797) 3.552CHRNA3, CHRNA5
membrane protein complex (GO:0098796) 2.842CHRNA3, CHRNA5
membrane part (GO:0044425) 0.952CHRNA3, CHRNA5

NET-GE enrichment

Term New enriched termICP valueGenes
synaptic membrane (GO:0097060) -4.220.004CHRNA3, CHRNA5
receptor complex (GO:0043235) -4.010.006CHRNA3, CHRNA5
transmembrane transporter complex (GO:1902495) -4.060.038CHRNA3, CHRNA5
transporter complex (GO:1990351) -4.040.007CHRNA3, CHRNA5
acetylcholine-gated channel complex (GO:0005892) -6.670.0CHRNA3, CHRNA5
postsynaptic membrane (GO:0045211) -4.470.035CHRNA3, CHRNA5
synapse part (GO:0044456) -3.420.014CHRNA3, CHRNA5
ion channel complex (GO:0034702) -4.180.005CHRNA3, CHRNA5