Disease table of SHORT-RIB THORACIC DYSPLASIA OMIM ID: PS208500

Gene-disease associations table

GeneAssociated with SHORT-RIB THORACIC DYSPLASIA inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
IFT140ClinVar, OMIM, HUMSAVARHGNC link16p13.32PS208500, PS268000
IFT80ClinVar, OMIM, HUMSAVARHGNC link3q25.331PS208500
NEK1ClinVar, OMIM, HUMSAVARHGNC link4q331PS208500
IFT172ClinVar, OMIM, HUMSAVARHGNC link2p23.32PS208500, PS268000
EVCClinVar, OMIM, HUMSAVARHGNC link4p16.22193530, PS208500
TTC21BClinVar, OMIM, HUMSAVARHGNC link2q24.33PS256100, PS208500, PS209900
EVC2ClinVar, OMIM, HUMSAVARHGNC link4p16.22193530, PS208500
WDR35ClinVar, OMIM, HUMSAVARHGNC link2p24.12PS218330, PS208500
KIAA0586ClinVar, OMIMHGNC link14q23.12PS213300, PS208500
CEP120ClinVar, OMIM, HUMSAVARHGNC link5q23.21PS208500
WDR19ClinVar, OMIM, HUMSAVARHGNC link4p144PS256100, 616307, PS208500, PS218330
DYNC2H1ClinVar, OMIM, HUMSAVARHGNC link11q22.31PS208500
WDR60ClinVar, OMIM, HUMSAVARHGNC link7q36.31PS208500
WDR34ClinVar, OMIM, HUMSAVARHGNC link9q34.111PS208500

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
4p16.22EVC2, EVC
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
4p162EVC2, EVC
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
2p22WDR35, IFT172
4p13EVC2, WDR19, EVC
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
2p2WDR35, IFT172
4p3EVC2, WDR19, EVC
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
23WDR35, TTC21B, IFT172
44EVC2, WDR19, NEK1, EVC
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
IFT140WDR35No2IFT122, C11ORF74
IFT140WDR19No2IFT122, C11ORF74
IFT140WDR60No1FBXW11
IFT80IFT172No3IFT57, LCA5, CORO1A
IFT80CEP120No1LCA5
NEK1EVC2No1YWHAH
NEK1CEP120No1WDR83
NEK1WDR34No1XPO1
IFT172CEP120No2LCA5, PCM1
EVC2CEP120No1UNC45A
WDR35WDR19No2IFT122, C11ORF74
WDR35DYNC2H1No1NEDD1
KIAA0586CEP120Yes2CENPJ, KIAA0753
KIAA0586WDR60No1DYNLT1
KIAA0586WDR34No1DYNLT1
WDR60WDR34No4DYNLT1, TMEM25, DYNLRB1, DYNLL1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
NEK1TTC21BNo1KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
IFT140IFT172No-2UBC, WDR19
IFT140TTC21BYesbinding8WDR35, IFT43, IFT27, IFT88, IFT52, IFT122, WDR19, IFT81
IFT140WDR35Yesbinding5IFT52, IFT122, IFT43, TTC21B, WDR19
IFT140KIAA0586No-1UBC
IFT140WDR19Yesbinding8WDR35, IFT43, IFT88, IFT52, IFT27, IFT122, TTC21B, IFT81
IFT140DYNC2H1No-1DYNC2LI1
IFT140WDR34No-1UBC
IFT172TTC21BNo-1WDR19
IFT172WDR35No-1WDR19
IFT172KIAA0586No-1UBC
IFT172WDR19Yesbinding0
IFT172WDR34No-1UBC
TTC21BWDR35Yesbinding5IFT52, IFT140, IFT43, IFT122, WDR19
TTC21BWDR19Yesbinding8WDR35, IFT81, IFT140, IFT27, IFT52, IFT122, IFT43, IFT88
WDR35WDR19Yesbinding5IFT52, IFT140, IFT43, TTC21B, IFT122
KIAA0586WDR34No-1UBC
DYNC2H1WDR60No-2DYNLRB1, DYNLRB2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
EVCEVC2yes, they interactThey are in interaction. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Organelle biogenesis and maintenanceR-HSA-18522414.639WDR35, IFT140, IFT172, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
Assembly of the primary ciliumR-HSA-56178335.449WDR35, IFT140, IFT172, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
Intraflagellar transportR-HSA-56209247.259WDR35, IFT140, IFT172, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
Signal TransductionR-HSA-1625821.788EVC, WDR35, IFT140, IFT172, EVC2, WDR19, TTC21B, DYNC2H1
Signaling by HedgehogR-HSA-53583515.798EVC, WDR35, IFT140, IFT172, EVC2, WDR19, TTC21B, DYNC2H1
Hedgehog 'off' stateR-HSA-56107876.196WDR35, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
Hedgehog 'on' stateR-HSA-56326846.622EVC, EVC2
Activation of SMOR-HSA-56358389.662EVC, EVC2

NET-GE enrichment

Term New enriched termICP valueGenes
Hedgehog 'off' state (R-HSA-5610787) -6.190.0WDR35, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
Organelle biogenesis and maintenance (R-HSA-1852241) -4.630.0WDR35, IFT140, IFT172, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
Activation of SMO (R-HSA-5635838) -9.660.005EVC, EVC2
Signaling by Hedgehog (R-HSA-5358351) -5.790.0EVC, WDR35, IFT140, IFT172, EVC2, WDR19, TTC21B, DYNC2H1
Assembly of the primary cilium (R-HSA-5617833) -5.440.0WDR35, IFT140, IFT172, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
Intraflagellar transport (R-HSA-5620924) -7.250.0WDR35, IFT140, IFT172, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
Signal Transduction (R-HSA-162582) -1.780.041EVC, WDR35, IFT140, IFT172, EVC2, WDR19, TTC21B, DYNC2H1
GO - molecular function annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185WDR34, WDR35, NEK1, CEP120, DYNC2H1
protein binding (GO:0005515) 0.463WDR34, NEK1, CEP120
adenyl nucleotide binding (GO:0030554) 2.42NEK1, DYNC2H1
purine ribonucleoside triphosphate binding (GO:0035639) 2.222NEK1, DYNC2H1
carbohydrate derivative binding (GO:0097367) 2.032NEK1, DYNC2H1
ribonucleotide binding (GO:0032553) 2.192NEK1, DYNC2H1
nucleotide binding (GO:0000166) 1.962NEK1, DYNC2H1
small molecule binding (GO:0036094) 1.892NEK1, DYNC2H1
catalytic activity (GO:0003824) 1.052NEK1, DYNC2H1
purine ribonucleoside binding (GO:0032550) 2.222NEK1, DYNC2H1
adenyl ribonucleotide binding (GO:0032559) 2.412NEK1, DYNC2H1
ATP binding (GO:0005524) 2.432NEK1, DYNC2H1
purine nucleoside binding (GO:0001883) 2.222NEK1, DYNC2H1
ribonucleoside binding (GO:0032549) 2.222NEK1, DYNC2H1
purine ribonucleotide binding (GO:0032555) 2.22NEK1, DYNC2H1
purine nucleotide binding (GO:0017076) 2.192NEK1, DYNC2H1
organic cyclic compound binding (GO:0097159) 1.052NEK1, DYNC2H1
heterocyclic compound binding (GO:1901363) 1.062NEK1, DYNC2H1
nucleoside phosphate binding (GO:1901265) 1.962NEK1, DYNC2H1
nucleoside binding (GO:0001882) 2.212NEK1, DYNC2H1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism process (GO:0044699) 0.4812EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
developmental process (GO:0032502) 1.3611EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
cellular process (GO:0009987) 0.2611WDR35, KIAA0586, CEP120, IFT140, IFT172, NEK1, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
cellular component organization (GO:0016043) 1.2411IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
regulation of cellular process (GO:0050794) 0.511EVC, IFT172, CEP120, KIAA0586, IFT140, EVC2, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
single-organism developmental process (GO:0044767) 1.4911EVC, WDR35, KIAA0586, CEP120, IFT140, IFT172, NEK1, WDR19, TTC21B, IFT80, DYNC2H1
biological regulation (GO:0065007) 0.3911EVC, IFT172, CEP120, KIAA0586, IFT140, EVC2, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
single-organism cellular process (GO:0044763) 0.6511IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
regulation of biological process (GO:0050789) 0.4511EVC, IFT172, KIAA0586, CEP120, IFT140, EVC2, NEK1, WDR19, TTC21B, IFT80, DYNC2H1
cellular component organization or biogenesis (GO:0071840) 1.2211IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
cell projection organization (GO:0030030) 3.1410IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
organelle organization (GO:0006996) 2.029IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
single-organism organelle organization (GO:1902589) 2.689IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
cilium assembly (GO:0042384) 4.778IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
cellular developmental process (GO:0048869) 1.828IFT172, KIAA0586, CEP120, IFT140, WDR19, TTC21B, IFT80, DYNC2H1
cellular component assembly involved in morphogenesis (GO:0010927) 4.298IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
cellular component assembly (GO:0022607) 2.148IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
organelle assembly (GO:0070925) 3.758IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
signal transduction (GO:0007165) 1.288EVC, IFT172, KIAA0586, EVC2, NEK1, WDR19, IFT80, TTC21B
cell projection assembly (GO:0030031) 4.198IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
cilium organization (GO:0044782) 4.678IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
anatomical structure formation involved in morphogenesis (GO:0048646) 3.018IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
microtubule-based process (GO:0007017) 3.547WDR35, CEP120, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
cell projection morphogenesis (GO:0048858) 4.057IFT172, KIAA0586, IFT140, WDR19, TTC21B, IFT80, DYNC2H1
cilium morphogenesis (GO:0060271) 5.547IFT172, KIAA0586, IFT140, WDR19, TTC21B, IFT80, DYNC2H1
smoothened signaling pathway (GO:0007224) 5.457EVC, IFT172, KIAA0586, EVC2, WDR19, IFT80, TTC21B
anatomical structure development (GO:0048856) 1.587EVC, IFT172, CEP120, IFT140, WDR19, TTC21B, DYNC2H1
cellular component morphogenesis (GO:0032989) 3.57IFT172, KIAA0586, IFT140, WDR19, TTC21B, IFT80, DYNC2H1
cell surface receptor signaling pathway (GO:0007166) 2.097EVC, IFT172, KIAA0586, EVC2, WDR19, IFT80, TTC21B
anatomical structure morphogenesis (GO:0009653) 2.537IFT172, KIAA0586, IFT140, WDR19, TTC21B, IFT80, DYNC2H1
cell part morphogenesis (GO:0032990) 3.997IFT172, KIAA0586, IFT140, WDR19, TTC21B, IFT80, DYNC2H1
regulation of smoothened signaling pathway (GO:0008589) 5.626EVC, IFT172, IFT140, IFT80, TTC21B, DYNC2H1
multicellular organismal process (GO:0032501) 1.456EVC, IFT172, IFT140, WDR19, TTC21B, DYNC2H1
single-multicellular organism process (GO:0044707) 1.786EVC, IFT172, IFT140, WDR19, TTC21B, DYNC2H1
regulation of signal transduction (GO:0009966) 1.846EVC, IFT172, IFT140, IFT80, TTC21B, DYNC2H1
regulation of response to stimulus (GO:0048583) 1.546EVC, IFT172, IFT140, IFT80, TTC21B, DYNC2H1
regulation of signaling (GO:0023051) 1.726EVC, IFT172, IFT140, IFT80, TTC21B, DYNC2H1
regulation of cell communication (GO:0010646) 1.736EVC, IFT172, IFT140, IFT80, TTC21B, DYNC2H1
localization (GO:0051179) 1.46WDR35, CEP120, IFT140, WDR19, TTC21B, DYNC2H1
cellular localization (GO:0051641) 2.326WDR35, CEP120, IFT140, WDR19, TTC21B, DYNC2H1
protein localization (GO:0008104) 2.365TTC21B, WDR35, IFT140, DYNC2H1, WDR19
intraciliary transport (GO:0042073) 6.435WDR35, DYNC2H1, IFT140, TTC21B, WDR19
movement of cell or subcellular component (GO:0006928) 2.615WDR35, IFT140, TTC21B, DYNC2H1, WDR19
intracellular protein transport (GO:0006886) 3.25WDR35, IFT140, TTC21B, DYNC2H1, WDR19
cytoskeleton-dependent intracellular transport (GO:0030705) 4.965WDR35, DYNC2H1, IFT140, TTC21B, WDR19
animal organ development (GO:0048513) 2.535EVC, IFT172, IFT140, DYNC2H1, WDR19
intraciliary retrograde transport (GO:0035721) 7.535TTC21B, WDR35, IFT140, DYNC2H1, WDR19
organic substance transport (GO:0071702) 2.155WDR35, IFT140, TTC21B, DYNC2H1, WDR19
positive regulation of biological process (GO:0048518) 1.25EVC, IFT172, CEP120, IFT80, DYNC2H1
macromolecule localization (GO:0033036) 2.345TTC21B, WDR35, IFT140, DYNC2H1, WDR19
transport (GO:0006810) 1.515TTC21B, WDR35, IFT140, WDR19, DYNC2H1
establishment of protein localization (GO:0045184) 2.535WDR35, DYNC2H1, IFT140, TTC21B, WDR19
single-organism transport (GO:0044765) 2.185TTC21B, WDR35, IFT140, WDR19, DYNC2H1
establishment of localization by movement along microtubule (GO:0010970) 5.145TTC21B, WDR35, IFT140, WDR19, DYNC2H1
establishment of localization in cell (GO:0051649) 2.475TTC21B, WDR35, IFT140, WDR19, DYNC2H1
establishment of localization (GO:0051234) 1.485TTC21B, WDR35, IFT140, WDR19, DYNC2H1
single-organism localization (GO:1902578) 2.095TTC21B, WDR35, IFT140, WDR19, DYNC2H1
protein complex localization (GO:0031503) 5.625WDR35, IFT140, TTC21B, DYNC2H1, WDR19
intracellular transport (GO:0046907) 2.675WDR35, DYNC2H1, IFT140, TTC21B, WDR19
microtubule-based movement (GO:0007018) 4.395TTC21B, WDR35, IFT140, DYNC2H1, WDR19
protein transport along microtubule (GO:0098840) 6.435TTC21B, WDR35, IFT140, DYNC2H1, WDR19
protein transport (GO:0015031) 2.625WDR35, DYNC2H1, IFT140, TTC21B, WDR19
single-organism intracellular transport (GO:1902582) 3.595WDR35, DYNC2H1, IFT140, TTC21B, WDR19
single-organism cellular localization (GO:1902580) 3.165TTC21B, WDR35, IFT140, DYNC2H1, WDR19
positive regulation of cellular process (GO:0048522) 1.35EVC, IFT80, IFT172, DYNC2H1, CEP120
pattern specification process (GO:0007389) 3.794TTC21B, IFT172, IFT140, DYNC2H1
positive regulation of response to stimulus (GO:0048584) 2.184EVC, IFT172, IFT80, DYNC2H1
cellular macromolecule localization (GO:0070727) 3.14TTC21B, WDR35, IFT140, WDR19
positive regulation of signal transduction (GO:0009967) 2.54EVC, IFT172, IFT80, DYNC2H1
cell differentiation (GO:0030154) 2.144IFT80, IFT172, DYNC2H1, CEP120
positive regulation of signaling (GO:0023056) 2.414EVC, IFT172, IFT80, DYNC2H1
positive regulation of smoothened signaling pathway (GO:0045880) 6.554EVC, IFT172, IFT80, DYNC2H1
system development (GO:0048731) 2.924EVC, IFT140, TTC21B, WDR19
positive regulation of cell communication (GO:0010647) 2.414EVC, IFT172, IFT80, DYNC2H1
cellular protein localization (GO:0034613) 3.114WDR35, IFT140, TTC21B, WDR19
regionalization (GO:0003002) 4.244TTC21B, IFT172, IFT140, DYNC2H1
organic substance metabolic process (GO:0071704) 0.633IFT172, NEK1, DYNC2H1
primary metabolic process (GO:0044238) 0.693IFT172, NEK1, DYNC2H1
organ morphogenesis (GO:0009887) 3.553IFT140, IFT80, WDR19
limb morphogenesis (GO:0035108) 5.053IFT140, WDR19, DYNC2H1
dorsal/ventral pattern formation (GO:0009953) 5.63IFT172, TTC21B, DYNC2H1
heart development (GO:0007507) 4.243IFT172, IFT140, DYNC2H1
protein metabolic process (GO:0019538) 1.453IFT172, NEK1, DYNC2H1
determination of left/right symmetry (GO:0007368) 5.383IFT172, IFT140, DYNC2H1
appendage morphogenesis (GO:0035107) 5.053IFT140, WDR19, DYNC2H1
macromolecule metabolic process (GO:0043170) 0.833IFT172, NEK1, DYNC2H1
protein localization to organelle (GO:0033365) 3.573TTC21B, WDR35, IFT140
protein localization to cilium (GO:0061512) 6.433TTC21B, WDR35, IFT140
embryonic morphogenesis (GO:0048598) 3.723IFT172, DYNC2H1, WDR19
metabolic process (GO:0008152) 0.583IFT172, NEK1, DYNC2H1
determination of bilateral symmetry (GO:0009855) 5.373IFT172, IFT140, DYNC2H1
specification of symmetry (GO:0009799) 5.363IFT172, IFT140, DYNC2H1
multicellular organism development (GO:0007275) 2.543IFT172, DYNC2H1, WDR19
regulation of cell morphogenesis (GO:0022604) 3.42IFT140, CEP120
skeletal system morphogenesis (GO:0048705) 4.982IFT140, WDR19
embryonic limb morphogenesis (GO:0030326) 5.242DYNC2H1, WDR19
regulation of anatomical structure morphogenesis (GO:0022603) 2.792IFT140, CEP120
cell differentiation in spinal cord (GO:0021515) 6.022IFT172, DYNC2H1
embryonic appendage morphogenesis (GO:0035113) 5.242DYNC2H1, WDR19
negative regulation of epithelial cell proliferation (GO:0050680) 4.982IFT172, IFT80
regulation of cellular component organization (GO:0051128) 2.012IFT140, CEP120
regulation of cell projection assembly (GO:0060491) 4.662IFT140, CEP120
microtubule cytoskeleton organization (GO:0000226) 4.132IFT172, CEP120
regulation of cell projection organization (GO:0031344) 3.382IFT140, CEP120
regulation of protein localization (GO:0032880) 2.882KIAA0586, CEP120
regulation of organelle organization (GO:0033043) 2.722IFT140, CEP120
regulation of organelle assembly (GO:1902115) 4.72IFT140, CEP120
proteolysis (GO:0006508) 2.732IFT172, DYNC2H1
regulation of cilium assembly (GO:1902017) 5.72IFT140, CEP120
central nervous system neuron differentiation (GO:0021953) 5.172IFT172, DYNC2H1
regulation of cell proliferation (GO:0042127) 2.412IFT172, IFT80
negative regulation of cell proliferation (GO:0008285) 3.262IFT172, IFT80
spinal cord motor neuron differentiation (GO:0021522) 6.512IFT172, DYNC2H1
neuron differentiation (GO:0030182) 4.172IFT172, DYNC2H1
regulation of developmental process (GO:0050793) 2.12IFT140, CEP120
cytoplasmic microtubule organization (GO:0031122) 5.972IFT172, CEP120
negative regulation of biological process (GO:0048519) 1.332IFT172, IFT80
protein processing (GO:0016485) 4.622IFT172, DYNC2H1
cytoskeleton organization (GO:0007010) 3.222IFT172, CEP120
regulation of localization (GO:0032879) 1.942CEP120, KIAA0586
regulation of epithelial cell proliferation (GO:0050678) 4.062IFT172, IFT80
protein maturation (GO:0051604) 4.482IFT172, DYNC2H1
regulation of cellular component biogenesis (GO:0044087) 3.082IFT140, CEP120
cell cycle process (GO:0022402) 2.752NEK1, CEP120
negative regulation of cellular process (GO:0048523) 1.412IFT172, IFT80

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of smoothened signaling pathway (GO:0008589) -5.620.0EVC, IFT172, IFT80, TTC21B, DYNC2H1
protein localization (GO:0008104) -2.360.034IFT140, TTC21B, DYNC2H1, WDR19
cell projection organization (GO:0030030) -3.140.001IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, WDR60, DYNC2H1
cell projection assembly (GO:0030031) -4.190.0IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
intraciliary transport (GO:0042073) -6.430.0WDR35, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
cellular component assembly involved in morphogenesis (GO:0010927) -4.290.0IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
digestive system development (GO:0055123) NEW7.530.01IFT172, WDR19
cellular component assembly (GO:0022607) -2.140.001IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
positive regulation of smoothened signaling pathway (GO:0045880) -6.550.0EVC, IFT172, IFT80, DYNC2H1
anatomical structure morphogenesis (GO:0009653) -2.530.039IFT172, KIAA0586, IFT140, WDR19, IFT80, DYNC2H1
cellular component organization or biogenesis (GO:0071840) -1.220.016IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, WDR60, DYNC2H1
cellular component organization (GO:0016043) -1.240.015WDR35, CEP120, KIAA0586, IFT140, IFT172, NEK1, WDR19, IFT80, WDR60, DYNC2H1
cytoskeleton-dependent intracellular transport (GO:0030705) -4.960.0WDR35, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
smoothened signaling pathway involved in dorsal/ventral neural tube patterning (GO:0060831) NEW7.780.006IFT172, WDR19
ciliary receptor clustering involved in smoothened signaling pathway (GO:0060830) NEW8.630.005IFT172, WDR19
intraciliary retrograde transport (GO:0035721) -7.530.0WDR35, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
macromolecule localization (GO:0033036) -2.340.037IFT140, TTC21B, DYNC2H1, WDR19
anatomical structure formation involved in morphogenesis (GO:0048646) -3.010.0IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
developmental process (GO:0032502) -1.360.003EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
spinal cord motor neuron differentiation (GO:0021522) -6.510.035IFT172, DYNC2H1
cilium assembly (GO:0042384) -4.770.0IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
cytoplasmic microtubule organization (GO:0031122) -5.970.045IFT172, CEP120
single-organism developmental process (GO:0044767) -1.490.001EVC, WDR35, KIAA0586, CEP120, IFT140, IFT172, NEK1, WDR19, TTC21B, IFT80, DYNC2H1
microtubule-based transport (GO:0010970) -5.140.0WDR35, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
organelle assembly (GO:0070925) -3.750.0WDR35, CEP120, KIAA0586, IFT140, IFT172, NEK1, WDR19, IFT80, DYNC2H1
cellular localization (GO:0051641) -2.320.024TTC21B, IFT140, WDR19, CEP120
ear morphogenesis (GO:0042471) NEW7.940.006IFT172, WDR19
microtubule-based process (GO:0007017) -3.540.002WDR35, CEP120, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
dorsal/ventral pattern formation (GO:0009953) -5.60.004IFT172, TTC21B, DYNC2H1
smoothened signaling pathway (GO:0007224) -5.450.0EVC, IFT172, KIAA0586, EVC2, WDR19, IFT80, TTC21B
microtubule-based movement (GO:0007018) -4.390.0WDR35, IFT140, IFT172, WDR19, TTC21B, DYNC2H1
protein localization to cilium (GO:0061512) -6.430.004IFT140, TTC21B
cilium organization (GO:0044782) -4.670.0IFT172, KIAA0586, IFT140, WDR35, NEK1, WDR19, IFT80, DYNC2H1
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1114EVC, WDR35, CEP120, KIAA0586, IFT140, IFT172, EVC2, WDR34, NEK1, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
organelle (GO:0043226) 0.414EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, EVC2, WDR34, NEK1, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
organelle part (GO:0044422) 0.7914EVC, WDR35, KIAA0586, CEP120, IFT140, IFT172, EVC2, WDR34, NEK1, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
intracellular part (GO:0044424) 0.2813EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, EVC2, WDR34, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
cytoplasm (GO:0005737) 1.0112EVC, WDR35, KIAA0586, CEP120, IFT140, EVC2, WDR34, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
cytoskeleton (GO:0005856) 2.5512EVC, WDR35, KIAA0586, CEP120, IFT140, EVC2, WDR34, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
intracellular non-membrane-bounded organelle (GO:0043232) 1.7612EVC, WDR35, KIAA0586, CEP120, IFT140, EVC2, WDR34, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
cell projection part (GO:0044463) 2.9712EVC, IFT172, KIAA0586, IFT140, WDR35, EVC2, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
intracellular organelle part (GO:0044446) 0.8112EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, WDR34, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
intracellular organelle (GO:0043229) 0.5112EVC, WDR35, KIAA0586, CEP120, IFT140, EVC2, WDR34, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
non-membrane-bounded organelle (GO:0043228) 1.7612EVC, WDR35, CEP120, KIAA0586, IFT140, EVC2, WDR34, NEK1, WDR19, IFT80, TTC21B, DYNC2H1
ciliary part (GO:0044441) 4.0512EVC, IFT172, KIAA0586, IFT140, WDR35, EVC2, WDR34, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
cell projection (GO:0042995) 2.4711EVC, IFT172, IFT140, WDR35, EVC2, WDR34, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
cilium (GO:0005929) 3.8911EVC, IFT172, IFT140, WDR35, EVC2, WDR34, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
cytoskeletal part (GO:0044430) 2.4910EVC, WDR35, KIAA0586, CEP120, IFT140, IFT172, WDR34, NEK1, IFT80, DYNC2H1
ciliary tip (GO:0097542) 6.049WDR35, IFT140, IFT172, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
primary cilium (GO:0072372) 4.649WDR35, IFT140, IFT172, WDR34, WDR60, WDR19, TTC21B, IFT80, DYNC2H1
microtubule organizing center (GO:0005815) 3.429EVC, WDR35, KIAA0586, CEP120, IFT140, IFT172, WDR34, NEK1, IFT80
protein complex (GO:0043234) 1.517WDR35, IFT140, IFT172, WDR19, TTC21B, IFT80, DYNC2H1
macromolecular complex (GO:0032991) 1.357WDR35, IFT140, IFT172, WDR19, TTC21B, IFT80, DYNC2H1
ciliary basal body (GO:0036064) 5.366EVC, WDR35, KIAA0586, IFT140, IFT172, WDR34
centrosome (GO:0005813) 3.756WDR35, CEP120, KIAA0586, IFT140, NEK1, IFT80
membrane-bounded organelle (GO:0043227) 0.475EVC2, IFT172, NEK1, WDR60, DYNC2H1
axoneme (GO:0005930) 5.535WDR34, WDR35, IFT172, IFT140, DYNC2H1
intraciliary transport particle A (GO:0030991) 7.724WDR35, IFT140, TTC21B, WDR19
membrane (GO:0016020) 0.684EVC, DYNC2H1, WDR19, EVC2
cytoplasmic part (GO:0044444) 0.824WDR34, NEK1, CEP120, DYNC2H1
plasma membrane (GO:0005886) 1.394EVC, DYNC2H1, WDR19, EVC2
extracellular organelle (GO:0043230) 1.893IFT172, WDR60, DYNC2H1
intracellular membrane-bounded organelle (GO:0043231) 0.63NEK1, EVC2, DYNC2H1
microtubule organizing center part (GO:0044450) 4.83WDR34, NEK1, CEP120
extracellular vesicle (GO:1903561) 1.893IFT172, WDR60, DYNC2H1
extracellular region part (GO:0044421) 1.573IFT172, WDR60, DYNC2H1
vesicle (GO:0031982) 1.643IFT172, WDR60, DYNC2H1
plasma membrane region (GO:0098590) 2.972EVC, EVC2
photoreceptor connecting cilium (GO:0032391) 6.282IFT140, WDR19
extracellular exosome (GO:0070062) 1.892WDR60, DYNC2H1
intraciliary transport particle B (GO:0030992) 6.862IFT172, IFT80
ciliary membrane (GO:0060170) 5.432EVC, EVC2
integral component of membrane (GO:0016021) 1.142EVC, EVC2
cell projection membrane (GO:0031253) 4.112EVC, EVC2
nucleus (GO:0005634) 1.072NEK1, EVC2
centriole (GO:0005814) 5.152WDR34, CEP120
membrane-bounded vesicle (GO:0031988) 1.712WDR60, DYNC2H1
nuclear part (GO:0044428) 1.552TTC21B, WDR19
membrane part (GO:0044425) 0.952EVC, EVC2
nonmotile primary cilium (GO:0031513) 5.142IFT140, WDR19
plasma membrane part (GO:0044459) 1.952EVC, EVC2
bounding membrane of organelle (GO:0098588) 2.392EVC, EVC2
intrinsic component of membrane (GO:0031224) 1.132EVC, EVC2
organelle membrane (GO:0031090) 1.972EVC, EVC2

NET-GE enrichment

Term New enriched termICP valueGenes
ciliary basal body (GO:0036064) -5.360.0EVC, IFT172, KIAA0586, IFT140, WDR35, WDR34
intraciliary transport particle A (GO:0030991) -7.720.0TTC21B, WDR35, IFT140, IFT172, WDR19
primary cilium (GO:0072372) -4.640.008IFT172, IFT140, DYNC2H1, WDR19
microtubule organizing center (GO:0005815) -3.420.0EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, WDR34, NEK1, IFT80
intracellular non-membrane-bounded organelle (GO:0043232) -1.760.0WDR35, CEP120, KIAA0586, IFT140, EVC2, WDR34, NEK1, WDR19, TTC21B, IFT80
intraciliary transport particle B (GO:0030992) -6.860.008IFT172, IFT80
centrosome (GO:0005813) -3.750.0WDR35, CEP120, KIAA0586, IFT140, NEK1, IFT80
cell projection part (GO:0044463) -2.970.011EVC, WDR35, KIAA0586, IFT140, IFT172, EVC2, WDR34, DYNC2H1
cilium (GO:0005929) -3.890.0EVC, IFT172, IFT140, EVC2, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
photoreceptor connecting cilium (GO:0032391) -6.280.012IFT172, IFT140, WDR19
nonmotile primary cilium (GO:0031513) -5.140.046IFT172, IFT140, WDR19
organelle (GO:0043226) -0.40.032EVC, WDR35, KIAA0586, CEP120, IFT140, IFT172, EVC2, WDR34, NEK1, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
non-membrane-bounded organelle (GO:0043228) -1.760.0WDR35, KIAA0586, CEP120, IFT140, EVC2, WDR34, NEK1, WDR19, TTC21B, IFT80
cytoskeletal part (GO:0044430) -2.490.005EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, WDR34, NEK1, IFT80, DYNC2H1
ciliary part (GO:0044441) -4.050.0EVC, WDR35, KIAA0586, IFT140, IFT172, EVC2, WDR34, DYNC2H1
cell projection (GO:0042995) -2.470.0EVC, IFT172, IFT140, EVC2, WDR60, WDR19, IFT80, TTC21B, DYNC2H1
axoneme (GO:0005930) -5.530.0WDR34, WDR35, IFT140, IFT172, DYNC2H1
organelle part (GO:0044422) -0.790.02EVC, IFT172, CEP120, KIAA0586, IFT140, WDR35, EVC2, WDR34, NEK1, IFT80, TTC21B, DYNC2H1