Disease table of BARDET-BIEDL SYNDROME OMIM ID: PS209900

Gene-disease associations table

Gene	Associated with BARDET-BIEDL SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
IFT27	ClinVar, OMIM, HUMSAVAR	HGNC link	22q12.3	1	PS209900
SDCCAG8	ClinVar, OMIM	HGNC link	1q43	2	PS209900, 613615
TRIM32	ClinVar, OMIM, HUMSAVAR	HGNC link	9q33.1	2	PS209900, PS253600
ARL6	ClinVar, OMIM, HUMSAVAR	HGNC link	3q11.2	2	PS209900, PS268000
CCDC28B	OMIM	HGNC link	1p35.2	1	PS209900
BBS5	ClinVar, OMIM, HUMSAVAR	HGNC link	2q31.1	1	PS209900
MKS1	OMIM, HUMSAVAR	HGNC link	17q22	3	PS213300, PS209900, PS249000
MKKS	ClinVar, OMIM, HUMSAVAR	HGNC link	20p12.2	2	236700, PS209900
BBS9	ClinVar, OMIM, HUMSAVAR	HGNC link	7p14.3	1	PS209900
KIF7	HUMSAVAR	HGNC link	15q26.1	5	146510, PS236680, PS209900, 607131, PS213300
TTC8	ClinVar, OMIM	HGNC link	14q31.3	2	PS209900, PS268000
LZTFL1	ClinVar, OMIM, HUMSAVAR	HGNC link	3p21.31	1	PS209900
TMEM67	OMIM	HGNC link	8q22.1	5	PS249000, PS213300, PS256100, 216360, PS209900
BBS1	ClinVar, OMIM, HUMSAVAR	HGNC link	11q13.2	1	PS209900
BBIP1	ClinVar, OMIM	HGNC link	10q25.2	1	PS209900
BBS2	ClinVar, OMIM, HUMSAVAR	HGNC link	16q13	2	PS209900, PS268000
TTC21B	HUMSAVAR	HGNC link	2q24.3	3	PS256100, PS208500, PS209900
BBS4	ClinVar, OMIM, HUMSAVAR	HGNC link	15q24.1	1	PS209900
BBS7	ClinVar, OMIM, HUMSAVAR	HGNC link	4q27	1	PS209900
CEP290	ClinVar, OMIM	HGNC link	12q21.32	5	PS249000, PS213300, PS204000, 610189, PS209900
BBS10	ClinVar, OMIM, HUMSAVAR	HGNC link	12q21.2	1	PS209900
BBS12	ClinVar, OMIM, HUMSAVAR	HGNC link	4q27	1	PS209900
WDPCP	ClinVar, OMIM	HGNC link	2p15	2	217085, PS209900

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
4q27	2	BBS12, BBS7

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
4q27	2	BBS12, BBS7
12q21	2	CEP290, BBS10

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
12q2	2	CEP290, BBS10
4q2	2	BBS12, BBS7
15q2	2	KIF7, BBS4

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
15q	2	KIF7, BBS4
2q	2	BBS5, TTC21B
4q	2	BBS12, BBS7
12q	2	CEP290, BBS10

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
12	2	CEP290, BBS10
1	2	CCDC28B, SDCCAG8
3	2	LZTFL1, ARL6
2	3	BBS5, WDPCP, TTC21B
4	2	BBS12, BBS7
15	2	KIF7, BBS4

Transcription Factors (TF) annotation from TRRUST

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SDCCAG8	BBS4	No	1	OFD1
SDCCAG8	CEP290	No	1	OFD1
TRIM32	MKS1	No	1	DNAJC7
TRIM32	MKKS	No	1	HSP90AA1
TRIM32	BBS9	No	1	TUBA1C
TRIM32	LZTFL1	No	2	CEP250, SDCBP
TRIM32	BBS1	No	1	GLIS2
TRIM32	BBS2	No	1	GLIS2
TRIM32	BBS4	No	1	CUL3
TRIM32	CEP290	No	2	YWHAH, DTNBP1
CCDC28B	MKKS	No	1	APP
BBS5	BBS9	No	1	LZTFL1
BBS5	TTC8	No	1	LZTFL1
BBS5	LZTFL1	Yes	1	LZTFL1
BBS5	BBS1	No	1	LZTFL1
BBS5	BBS2	No	1	LZTFL1
BBS5	BBS4	No	1	LZTFL1
BBS5	BBS7	No	1	LZTFL1
MKS1	BBIP1	No	1	SHMT2
MKS1	BBS2	No	1	THBS3
MKS1	BBS7	No	2	THBS3, KLK5
MKS1	CEP290	No	6	TPGS1, LRRC49, HAUS7, FKBP4, HAUS8, ECH1
MKS1	BBS10	No	1	XPO1
BBS9	TTC8	No	1	LZTFL1
BBS9	LZTFL1	Yes	1	LZTFL1
BBS9	BBS1	No	1	LZTFL1
BBS9	BBS2	No	1	LZTFL1
BBS9	BBS4	No	1	LZTFL1
BBS9	BBS7	No	1	LZTFL1
KIF7	LZTFL1	No	1	BBS4
KIF7	BBS4	Yes	1	PCM1
KIF7	BBS7	No	1	CCDC8
KIF7	CEP290	Yes	13	CCDC8, CEP128, CCDC61, SSX2IP, PIBF1, KIAA0753, CCDC77, TBC1D31, CEP72, CEP135, CEP131, MED4, PCM1
TTC8	LZTFL1	Yes	1	LZTFL1
TTC8	BBS1	No	1	LZTFL1
TTC8	BBS2	No	1	LZTFL1
TTC8	BBS4	No	1	LZTFL1
TTC8	BBS7	No	1	LZTFL1
LZTFL1	BBS1	Yes	1	LZTFL1
LZTFL1	BBS2	Yes	1	LZTFL1
LZTFL1	BBS4	Yes	1	LZTFL1
LZTFL1	BBS7	Yes	1	LZTFL1
TMEM67	CEP290	No	2	RAB2A, BCAP31
BBS1	BBS2	No	11	GLIS2, EXOC7, ALDOB, BHMT, KRT18, PAX2, LZTFL1, EPAS1, EEF1A1, FHOD1, HSCB
BBS1	BBS4	No	13	CALCA, EXOC7, FHOD1, BHMT, KRT18, DCTN1, PAX2, EIF3A, LZTFL1, EPAS1, EEF1A1, ALDOB, HSCB
BBS1	BBS7	No	5	ALDOB, KRT18, PAX2, FHOD1, LZTFL1
BBS2	BBS4	No	10	EXOC7, ALDOB, BHMT, KRT18, PAX2, LZTFL1, EPAS1, EEF1A1, FHOD1, HSCB
BBS2	BBS7	No	6	THBS3, FHOD1, KRT18, PAX2, LZTFL1, ALDOB
BBS4	BBS7	No	5	ALDOB, KRT18, PAX2, FHOD1, LZTFL1
BBS4	CEP290	No	4	OFD1, KIF7, PCM1, CEP162
BBS7	CEP290	No	1	CCDC8
CEP290	BBS10	No	1	CSNK1E

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
SDCCAG8	TTC21B	No	1	KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
IFT27	TTC21B	Yes	binding	6	IFT140, IFT52, IFT122, WDR19, IFT81, IFT88
SDCCAG8	ARL6	No	-	6	PAFAH1B1, TUBG2, TUBA1A, CLASP1, TUBGCP2, TUBG1
SDCCAG8	BBS5	No	-	1	AZI1
SDCCAG8	MKS1	No	-	1	CEP290
SDCCAG8	MKKS	No	-	1	HSP90AA1
SDCCAG8	BBS9	No	-	1	AZI1
SDCCAG8	TTC8	No	-	1	AZI1
SDCCAG8	LZTFL1	No	-	1	AZI1
SDCCAG8	TMEM67	No	-	1	CEP290
SDCCAG8	BBS1	No	-	1	AZI1
SDCCAG8	BBIP1	No	-	1	AZI1
SDCCAG8	BBS2	No	-	1	AZI1
SDCCAG8	BBS4	No	-	3	AZI1, HSP90AA1, PCM1
SDCCAG8	BBS7	No	-	1	AZI1
SDCCAG8	CEP290	Yes	binding	64	CEP76, TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP152, FGFR1OP, ALMS1, CSNK1D, PLK1, CEP135, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, DCTN2, CEP250, DYNLL1, TUBA1A, CNTRL, DYNC1H1, MAPRE1, DYNC1I2, PCM1, PCNT, TUBGCP2, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, AZI1, PRKAR2B, TUBB4B, CEP78, CENPJ, NINL, PAFAH1B1, CEP70, PPP2R1A, BORA, TUBGCP3, HAUS2, AJUBA, AURKA, CLASP1, NEK2, OFD1, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1, TUBG1
ARL6	BBS1	No	-	1	RAB8A
ARL6	CEP290	No	-	6	PAFAH1B1, TUBG2, TUBA1A, CLASP1, TUBGCP2, TUBG1
CCDC28B	BBS5	Yes	binding	5	TTC8, BBS2, BBS7, BBS4, BBS1
CCDC28B	MKKS	Yes	binding	1	BBS7
CCDC28B	BBS9	No	-	6	BBS5, BBS7, BBS1, BBS4, TTC8, BBS2
CCDC28B	TTC8	Yes	binding	5	BBS7, BBS2, BBS4, BBS5, BBS1
CCDC28B	LZTFL1	No	-	6	BBS5, BBS7, BBS1, BBS4, TTC8, BBS2
CCDC28B	BBS1	Yes	binding	5	TTC8, BBS2, BBS7, BBS4, BBS5
CCDC28B	BBIP1	No	-	6	BBS5, BBS7, BBS1, BBS4, TTC8, BBS2
CCDC28B	BBS2	Yes	binding	5	TTC8, BBS7, BBS4, BBS5, BBS1
CCDC28B	BBS4	Yes	binding	5	BBS7, BBS2, TTC8, BBS5, BBS1
CCDC28B	BBS7	Yes	binding	6	MKKS, BBS5, BBS1, BBS4, TTC8, BBS2
CCDC28B	BBS10	No	-	2	BBS7, MKKS
CCDC28B	BBS12	No	-	3	BBS7, MKKS, BBS1
BBS5	MKKS	No	-	2	CCDC28B, BBS7
BBS5	BBS9	Yes	binding	8	LZTFL1, AZI1, BBS1, BBS7, BBS4, TTC8, BBIP1, BBS2
BBS5	TTC8	Yes	binding	9	LZTFL1, CCDC28B, BBS1, BBS7, BBS9, BBS4, BBS2, BBIP1, AZI1
BBS5	LZTFL1	Yes	binding	8	AZI1, BBS1, BBS7, BBS9, BBS4, BBS2, BBIP1, TTC8
BBS5	BBS1	Yes	binding	9	LZTFL1, CCDC28B, AZI1, BBS9, BBS7, BBS4, TTC8, BBIP1, BBS2
BBS5	BBIP1	Yes	binding	8	LZTFL1, AZI1, BBS1, BBS7, BBS9, BBS4, BBS2, TTC8
BBS5	BBS2	Yes	binding	9	LZTFL1, CCDC28B, BBS1, BBS7, BBS9, BBS4, TTC8, BBIP1, AZI1
BBS5	BBS4	Yes	binding	9	CCDC28B, AZI1, BBS1, BBS7, BBS9, LZTFL1, TTC8, BBIP1, BBS2
BBS5	BBS7	Yes	binding	9	LZTFL1, CCDC28B, AZI1, BBS1, BBS9, BBS4, TTC8, BBIP1, BBS2
BBS5	CEP290	No	-	1	AZI1
BBS5	BBS10	No	-	1	BBS7
BBS5	BBS12	No	-	2	BBS7, BBS1
MKS1	TMEM67	Yes	binding	10	TMEM216, CEP290, TMEM17, TCTN2, AHI1, TCTN1, TMEM231, B9D1, CC2D2A, B9D2
MKS1	CEP290	Yes	binding	10	TMEM216, TCTN2, TMEM17, AHI1, TCTN1, TMEM67, TMEM231, B9D1, CC2D2A, B9D2
MKKS	BBS9	No	-	1	BBS7
MKKS	TTC8	No	-	2	CCDC28B, BBS7
MKKS	LZTFL1	No	-	1	BBS7
MKKS	BBS1	No	-	3	CCDC28B, BBS12, BBS7
MKKS	BBIP1	No	-	1	BBS7
MKKS	BBS2	No	-	2	CCDC28B, BBS7
MKKS	BBS4	No	-	3	CCDC28B, BBS7, HSP90AA1
MKKS	BBS7	Yes	binding	3	BBS10, CCDC28B, BBS12
MKKS	CEP290	No	-	1	HSP90AA1
MKKS	BBS10	Yes	binding	31	GRPEL2, HSPA9, CAD, HSPA5, CCT5, CCT3, ANKRD45, CCT8, HYOU1, EPRS, HSPA2, GRPEL1, HSPA13, CCT8L2, HSPA4L, CCT6B, CCT2, CCT4, CCT6A, HSPA12A, ACACA, HSPA8, HSPA12B, HSPE1, HSPA4, BBS7, HSPA6, HSPH1, ACACB, FARS2, HSPA14
MKKS	BBS12	Yes	binding	1	BBS7
BBS9	TTC8	Yes	binding	8	LZTFL1, AZI1, BBS5, BBS7, BBS1, BBS4, BBS2, BBIP1
BBS9	LZTFL1	Yes	binding	8	AZI1, BBS5, BBS7, BBS1, BBS4, BBS2, BBIP1, TTC8
BBS9	BBS1	Yes	binding	8	LZTFL1, AZI1, BBS5, BBS7, BBS4, TTC8, BBIP1, BBS2
BBS9	BBIP1	Yes	binding	8	LZTFL1, AZI1, BBS5, BBS7, BBS1, BBS4, BBS2, TTC8
BBS9	BBS2	Yes	binding	8	LZTFL1, AZI1, BBS5, BBS7, BBS1, BBS4, TTC8, BBIP1
BBS9	BBS4	Yes	binding	8	AZI1, BBS5, BBS7, BBS1, LZTFL1, TTC8, BBIP1, BBS2
BBS9	BBS7	Yes	binding	8	LZTFL1, AZI1, BBS1, BBS5, BBS4, TTC8, BBIP1, BBS2
BBS9	CEP290	No	-	1	AZI1
BBS9	BBS10	No	-	1	BBS7
BBS9	BBS12	No	-	2	BBS7, BBS1
TTC8	LZTFL1	Yes	binding	8	AZI1, BBS1, BBS7, BBS9, BBS4, BBS5, BBS2, BBIP1
TTC8	BBS1	Yes	binding	9	LZTFL1, CCDC28B, BBS5, BBS7, BBS9, BBS4, BBS2, BBIP1, AZI1
TTC8	BBIP1	Yes	binding	8	LZTFL1, AZI1, BBS1, BBS7, BBS9, BBS4, BBS5, BBS2
TTC8	BBS2	Yes	binding	10	LZTFL1, CCDC28B, BBS1, BBS7, BBS9, BBS4, BBS5, UBC, BBIP1, AZI1
TTC8	BBS4	Yes	binding	9	CCDC28B, BBS1, BBS7, BBS9, LZTFL1, BBS5, BBS2, BBIP1, AZI1
TTC8	BBS7	Yes	binding	9	LZTFL1, CCDC28B, BBS1, BBS9, BBS4, BBS5, BBS2, BBIP1, AZI1
TTC8	CEP290	No	-	2	UBC, AZI1
TTC8	BBS10	No	-	2	UBC, BBS7
TTC8	BBS12	No	-	2	BBS7, BBS1
LZTFL1	BBS1	Yes	binding	8	AZI1, BBS5, BBS7, BBS9, BBS4, BBS2, BBIP1, TTC8
LZTFL1	BBIP1	Yes	binding	8	AZI1, BBS1, BBS7, BBS9, BBS4, BBS5, BBS2, TTC8
LZTFL1	BBS2	Yes	binding	8	AZI1, BBS1, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1
LZTFL1	BBS4	Yes	binding	8	AZI1, BBS1, BBS7, BBS9, BBS5, TTC8, BBIP1, BBS2
LZTFL1	BBS7	Yes	binding	8	AZI1, BBS1, BBS9, BBS4, BBS5, BBS2, BBIP1, TTC8
LZTFL1	CEP290	No	-	1	AZI1
LZTFL1	BBS10	No	-	1	BBS7
LZTFL1	BBS12	No	-	2	BBS7, BBS1
TMEM67	CEP290	Yes	binding	10	TMEM216, TMEM17, TCTN2, AHI1, TCTN1, TMEM231, MKS1, B9D1, CC2D2A, B9D2
BBS1	BBIP1	Yes	binding	8	LZTFL1, AZI1, BBS5, BBS7, BBS9, BBS4, BBS2, TTC8
BBS1	BBS2	Yes	binding	9	LZTFL1, CCDC28B, BBS5, BBS7, BBS9, BBS4, TTC8, BBIP1, AZI1
BBS1	BBS4	Yes	binding	9	CCDC28B, AZI1, BBS5, BBS7, BBS9, LZTFL1, TTC8, BBIP1, BBS2
BBS1	BBS7	Yes	binding	10	BBS12, LZTFL1, CCDC28B, AZI1, BBS5, BBS9, BBS4, BBS2, BBIP1, TTC8
BBS1	CEP290	No	-	1	AZI1
BBS1	BBS10	No	-	1	BBS7
BBS1	BBS12	Yes	binding	1	BBS7
BBIP1	BBS2	Yes	binding	8	LZTFL1, AZI1, BBS1, BBS7, BBS9, BBS4, BBS5, TTC8
BBIP1	BBS4	Yes	binding	8	AZI1, BBS1, BBS7, BBS9, LZTFL1, BBS5, BBS2, TTC8
BBIP1	BBS7	Yes	binding	8	LZTFL1, AZI1, BBS1, BBS9, BBS4, BBS5, BBS2, TTC8
BBIP1	CEP290	No	-	1	AZI1
BBIP1	BBS10	No	-	1	BBS7
BBIP1	BBS12	No	-	2	BBS7, BBS1
BBS2	BBS4	Yes	binding	9	CCDC28B, BBS1, BBS7, BBS9, LZTFL1, BBS5, TTC8, BBIP1, AZI1
BBS2	BBS7	Yes	binding	9	LZTFL1, CCDC28B, BBS1, BBS9, BBS4, BBS5, TTC8, BBIP1, AZI1
BBS2	CEP290	No	-	2	UBC, AZI1
BBS2	BBS10	No	-	2	UBC, BBS7
BBS2	BBS12	No	-	2	BBS7, BBS1
BBS4	BBS7	Yes	binding	9	CCDC28B, AZI1, BBS1, BBS9, LZTFL1, BBS5, TTC8, BBIP1, BBS2
BBS4	CEP290	No	-	3	AZI1, HSP90AA1, PCM1
BBS4	BBS10	No	-	1	BBS7
BBS4	BBS12	No	-	2	BBS7, BBS1
BBS7	CEP290	No	-	1	AZI1
BBS7	BBS10	Yes	binding	1	MKKS
BBS7	BBS12	Yes	binding	2	MKKS, BBS1
CEP290	BBS10	No	-	1	UBC
BBS10	BBS12	No	-	2	BBS7, MKKS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Assembly of the primary cilium	R-HSA-5617833	5.44	19	BBS10, CEP290, TTC8, LZTFL1, MKS1, IFT27, BBS1, MKKS, TTC21B, BBS7, BBS9, BBS4, BBS5, BBS12, ARL6, BBIP1, BBS2, SDCCAG8, TMEM67
Organelle biogenesis and maintenance	R-HSA-1852241	4.63	19	BBS9, BBS10, CEP290, TTC8, LZTFL1, MKS1, IFT27, BBS1, TTC21B, BBS7, BBS4, TMEM67, MKKS, BBS5, BBS12, ARL6, BBIP1, BBS2, SDCCAG8
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.31	13	BBS10, LZTFL1, TTC8, MKKS, BBS1, BBS7, BBS9, BBS4, BBS5, BBS12, ARL6, BBIP1, BBS2
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.46	13	BBS10, LZTFL1, BBS12, MKKS, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.51	4	CEP290, SDCCAG8, MKS1, TMEM67
Hedgehog 'off' state	R-HSA-5610787	6.19	3	TTC21B, KIF7, MKS1
Signal Transduction	R-HSA-162582	1.78	3	TTC21B, KIF7, MKS1
Signaling by Hedgehog	R-HSA-5358351	5.79	3	TTC21B, KIF7, MKS1
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	6.68	2	CEP290, SDCCAG8
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.66	2	CEP290, SDCCAG8
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.03	2	CEP290, SDCCAG8
Centrosome maturation	R-HSA-380287	6.68	2	CEP290, SDCCAG8
Mitotic G2-G2/M phases	R-HSA-453274	6.04	2	CEP290, SDCCAG8
Cell Cycle, Mitotic	R-HSA-69278	4.16	2	CEP290, SDCCAG8
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.03	2	CEP290, SDCCAG8
Cell Cycle	R-HSA-1640170	3.89	2	CEP290, SDCCAG8
Intraflagellar transport	R-HSA-5620924	7.25	2	TTC21B, IFT27
G2/M Transition	R-HSA-69275	6.06	2	CEP290, SDCCAG8

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Hedgehog 'off' state (R-HSA-5610787)	-	6.19	0.014	CEP290, TTC21B, KIF7, MKS1
Organelle biogenesis and maintenance (R-HSA-1852241)	-	4.63	0.0	BBS9, BBS10, CEP290, TTC8, LZTFL1, MKS1, IFT27, BBS1, TTC21B, BBS7, BBS4, TMEM67, MKKS, BBS5, BBS12, ARL6, BBIP1, BBS2, SDCCAG8
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)	-	6.51	0.004	CEP290, SDCCAG8, MKS1, TMEM67
Cargo trafficking to the periciliary membrane (R-HSA-5620920)	-	7.31	0.0	BBS10, LZTFL1, TTC8, MKKS, BBS1, BBS7, BBS9, BBS4, BBS5, BBS12, ARL6, BBIP1, BBS2
Assembly of the primary cilium (R-HSA-5617833)	-	5.44	0.0	BBS10, CEP290, TTC8, LZTFL1, MKS1, IFT27, BBS1, MKKS, TTC21B, BBS7, BBS9, BBS4, BBS5, BBS12, ARL6, BBIP1, BBS2, SDCCAG8, TMEM67
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)	-	8.46	0.0	BBS10, LZTFL1, BBS12, MKKS, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	21	BBS10, CEP290, LZTFL1, BBS12, BBS4, MKS1, CCDC28B, IFT27, BBS9, BBS7, BBS2, BBS1, MKKS, BBS5, KIF7, TRIM32, TTC8, BBIP1, ARL6, SDCCAG8, TMEM67
protein binding (GO:0005515)	0.46	21	BBS10, CEP290, LZTFL1, BBS2, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS9, BBS7, TRIM32, TMEM67, BBS4, BBS5, KIF7, BBS12, TTC8, BBIP1, ARL6, SDCCAG8
transcription factor binding (GO:0008134)	3.46	9	BBS10, MKKS, TRIM32, BBS1, BBS7, BBS5, BBS4, BBS2, TTC8
RNA polymerase II transcription factor binding (GO:0001085)	5.08	8	BBS10, MKKS, BBS5, BBS7, BBS1, BBS4, TTC8, BBS2
RNA polymerase II repressing transcription factor binding (GO:0001103)	6.44	8	BBS10, MKKS, BBS5, BBS7, BBS1, BBS4, BBS2, TTC8
repressing transcription factor binding (GO:0070491)	5.71	8	BBS10, MKKS, BBS5, BBS7, BBS1, BBS4, BBS2, TTC8
organic cyclic compound binding (GO:0097159)	1.05	7	BBS10, BBS12, TRIM32, IFT27, MKKS, ARL6, KIF7
heterocyclic compound binding (GO:1901363)	1.06	7	BBS10, BBS12, TRIM32, IFT27, MKKS, ARL6, KIF7
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
nucleotide binding (GO:0000166)	1.96	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
small molecule binding (GO:0036094)	1.89	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
carbohydrate derivative binding (GO:0097367)	2.03	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
ribonucleotide binding (GO:0032553)	2.19	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
nucleoside phosphate binding (GO:1901265)	1.96	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
ribonucleoside binding (GO:0032549)	2.22	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
purine ribonucleotide binding (GO:0032555)	2.2	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
purine nucleotide binding (GO:0017076)	2.19	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
purine ribonucleoside binding (GO:0032550)	2.22	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
purine nucleoside binding (GO:0001883)	2.22	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
nucleoside binding (GO:0001882)	2.21	6	BBS10, BBS12, IFT27, MKKS, ARL6, KIF7
cytoskeletal protein binding (GO:0008092)	3.02	5	TRIM32, CEP290, BBS4, KIF7, TMEM67
adenyl ribonucleotide binding (GO:0032559)	2.41	4	BBS10, BBS12, MKKS, KIF7
ATP binding (GO:0005524)	2.43	4	BBS10, BBS12, MKKS, KIF7
adenyl nucleotide binding (GO:0030554)	2.4	4	BBS10, BBS12, MKKS, KIF7
catalytic activity (GO:0003824)	1.05	3	TRIM32, KIF7, BBS4
tubulin binding (GO:0015631)	4.1	3	CEP290, BBS4, KIF7
motor activity (GO:0003774)	4.81	2	BBS4, KIF7
hydrolase activity (GO:0016787)	1.9	2	BBS4, KIF7
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	2	BBS4, KIF7
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	2	BBS4, KIF7
pyrophosphatase activity (GO:0016462)	3.04	2	BBS4, KIF7
cation binding (GO:0043169)	1.4	2	TRIM32, ARL6
microtubule binding (GO:0008017)	4.42	2	CEP290, KIF7
phospholipid binding (GO:0005543)	3.91	2	ARL6, BBS5
lipid binding (GO:0008289)	3.26	2	ARL6, BBS5
unfolded protein binding (GO:0051082)	5.13	2	MKKS, TMEM67
ion binding (GO:0043167)	1.36	2	TRIM32, ARL6
guanyl nucleotide binding (GO:0019001)	3.73	2	ARL6, IFT27
nucleoside-triphosphatase activity (GO:0017111)	3.09	2	BBS4, KIF7
metal ion binding (GO:0046872)	1.41	2	TRIM32, ARL6
guanyl ribonucleotide binding (GO:0032561)	3.73	2	ARL6, IFT27
microtubule motor activity (GO:0003777)	5.34	2	BBS4, KIF7
GTP binding (GO:0005525)	3.78	2	ARL6, IFT27

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
RNA polymerase II transcription factor binding (GO:0001085)	-	5.08	0.0	BBS10, MKKS, BBS5, BBS7, BBS1, BBS4, BBS2, TTC8
anion binding (GO:0043168)	NEW	4.17	0.021	BBS10, CEP290, BBS12, MKKS, TRIM32, IFT27, BBS5, BBS7, KIF7, BBS4, BBS2, ARL6, SDCCAG8
transcription factor binding (GO:0008134)	-	3.46	0.0	BBS10, MKKS, TRIM32, BBS1, BBS7, BBS5, BBS4, TTC8, BBS2
protein binding (GO:0005515)	-	0.46	0.0	BBS10, CEP290, BBS12, LZTFL1, MKS1, CCDC28B, MKKS, BBS1, ARL6, BBS7, TRIM32, BBS9, BBS4, BBS5, KIF7, TTC8, BBIP1, BBS2, SDCCAG8, TMEM67
RNA polymerase II repressing transcription factor binding (GO:0001103)	-	6.44	0.0	BBS10, MKKS, BBS5, BBS7, BBS1, BBS4, BBS2, TTC8
repressing transcription factor binding (GO:0070491)	-	5.71	0.0	BBS10, MKKS, BBS5, BBS7, BBS1, BBS4, BBS2, TTC8

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	22	BBS10, BBS12, MKS1, TMEM67, BBS4, BBS2, KIF7, CCDC28B, IFT27, BBS5, WDPCP, SDCCAG8, ARL6, TRIM32, BBS9, BBS7, MKKS, TTC21B, BBIP1, CEP290, BBS1, TTC8
single-organism cellular process (GO:0044763)	0.65	22	BBS10, BBS12, MKS1, TMEM67, BBS4, BBS2, KIF7, CCDC28B, IFT27, BBS5, WDPCP, SDCCAG8, ARL6, TRIM32, BBS9, BBS7, MKKS, TTC21B, BBIP1, CEP290, BBS1, TTC8
single-organism process (GO:0044699)	0.48	22	BBS10, BBS12, MKS1, TMEM67, BBS4, TTC21B, KIF7, CCDC28B, IFT27, BBS5, WDPCP, SDCCAG8, ARL6, TRIM32, BBS9, BBS7, MKKS, BBS2, BBIP1, CEP290, BBS1, TTC8
cellular component organization (GO:0016043)	1.24	20	BBS10, CEP290, BBS12, MKKS, MKS1, TRIM32, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, CCDC28B, BBS5, BBS4, BBS2, BBIP1, TTC8, SDCCAG8, TMEM67
cellular component organization or biogenesis (GO:0071840)	1.22	20	BBS10, CEP290, BBS2, MKKS, MKS1, CCDC28B, BBS1, BBS9, ARL6, TTC21B, BBS7, WDPCP, TMEM67, BBS4, BBS5, BBS12, TTC8, BBIP1, TRIM32, SDCCAG8
cell projection organization (GO:0030030)	3.14	18	BBS10, CEP290, MKKS, MKS1, TRIM32, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, BBS2, CCDC28B, BBIP1, TTC8, TMEM67
single-organism developmental process (GO:0044767)	1.49	18	BBS10, CEP290, MKKS, MKS1, CCDC28B, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, BBS2, BBIP1, TTC8, SDCCAG8, TMEM67
biological regulation (GO:0065007)	0.39	18	BBS10, CEP290, TTC8, MKKS, MKS1, TRIM32, IFT27, BBS1, ARL6, BBS7, WDPCP, TMEM67, LZTFL1, BBS12, BBS2, BBS4, TTC21B, KIF7
developmental process (GO:0032502)	1.36	18	BBS10, CEP290, MKKS, MKS1, CCDC28B, TMEM67, ARL6, TTC21B, BBS7, WDPCP, BBS1, BBS4, BBS5, BBS9, BBS2, BBIP1, TTC8, SDCCAG8
organelle organization (GO:0006996)	2.02	18	BBS10, CEP290, TTC8, MKKS, MKS1, CCDC28B, TMEM67, ARL6, BBS7, WDPCP, BBS1, BBS4, BBS5, BBS9, BBS2, BBIP1, TRIM32, SDCCAG8
single-organism organelle organization (GO:1902589)	2.68	17	BBS10, CEP290, BBS2, MKKS, MKS1, CCDC28B, BBS1, ARL6, BBS7, WDPCP, TMEM67, BBS4, BBS5, BBS9, TTC8, BBIP1, TRIM32
cellular component assembly (GO:0022607)	2.14	17	BBS9, BBS10, CEP290, BBS2, MKKS, MKS1, CCDC28B, BBS1, BBS7, WDPCP, TMEM67, BBS4, BBS5, BBS12, TTC8, BBIP1, ARL6
regulation of biological process (GO:0050789)	0.45	17	BBS10, CEP290, BBS2, MKKS, MKS1, TRIM32, IFT27, TMEM67, BBS7, WDPCP, TTC8, LZTFL1, BBS12, TTC21B, BBS4, ARL6, KIF7
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	17	BBS10, CEP290, BBS4, MKS1, CCDC28B, BBS1, ARL6, BBS7, WDPCP, BBS9, MKKS, BBS5, BBS2, BBIP1, TTC8, SDCCAG8, TMEM67
regulation of cellular process (GO:0050794)	0.5	17	BBS10, CEP290, BBS12, LZTFL1, MKS1, TRIM32, IFT27, TMEM67, ARL6, TTC21B, BBS7, WDPCP, BBS4, MKKS, TTC8, BBS2, KIF7
cilium assembly (GO:0042384)	4.77	16	BBS9, BBS10, CEP290, TTC8, BBS4, MKS1, CCDC28B, BBS1, BBS7, WDPCP, TMEM67, MKKS, BBS5, ARL6, BBIP1, BBS2
cell projection assembly (GO:0030031)	4.19	16	BBS9, BBS10, CEP290, TTC8, BBS4, MKS1, CCDC28B, BBS1, BBS7, WDPCP, TMEM67, MKKS, BBS5, ARL6, BBIP1, BBS2
cilium organization (GO:0044782)	4.67	16	BBS10, CEP290, BBS4, MKS1, CCDC28B, BBS1, ARL6, BBS7, WDPCP, BBS9, MKKS, BBS5, BBS2, BBIP1, TTC8, TMEM67
organelle assembly (GO:0070925)	3.75	16	BBS10, CEP290, TTC8, BBS4, MKS1, CCDC28B, BBS1, BBS7, WDPCP, BBS9, MKKS, BBS5, ARL6, BBIP1, BBS2, TMEM67
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	16	BBS9, BBS10, CEP290, TTC8, BBS4, MKS1, CCDC28B, BBS1, BBS7, WDPCP, TMEM67, MKKS, BBS5, ARL6, BBIP1, BBS2
establishment of localization (GO:0051234)	1.48	15	CEP290, BBS12, MKKS, IFT27, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2
localization (GO:0051179)	1.4	15	CEP290, BBS12, BBS4, IFT27, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, MKKS, BBS5, BBS2, BBIP1, TTC8
establishment of protein localization (GO:0045184)	2.53	14	CEP290, TTC8, IFT27, BBS1, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, BBS12, ARL6, BBIP1, BBS2
transport (GO:0006810)	1.51	14	CEP290, BBS2, MKKS, IFT27, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS12, TTC21B, BBIP1, TTC8
multicellular organismal process (GO:0032501)	1.45	13	BBS10, BBS2, MKKS, MKS1, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS12, TTC21B, TTC8
cellular developmental process (GO:0048869)	1.82	13	CEP290, MKKS, MKS1, TRIM32, TMEM67, ARL6, TTC21B, BBS7, WDPCP, BBS9, BBS4, TTC8, BBS2
protein localization (GO:0008104)	2.36	13	CEP290, BBS12, IFT27, BBS1, ARL6, TTC21B, BBS7, BBS9, BBS4, BBS5, BBS2, BBIP1, TTC8
organic substance transport (GO:0071702)	2.15	13	CEP290, TTC8, IFT27, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS12, TTC21B, BBIP1, BBS2
protein transport (GO:0015031)	2.62	13	CEP290, TTC8, IFT27, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS12, TTC21B, BBIP1, BBS2
macromolecule localization (GO:0033036)	2.34	13	CEP290, BBS12, IFT27, BBS1, ARL6, TTC21B, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2
cellular localization (GO:0051641)	2.32	12	BBS12, MKKS, IFT27, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC21B, BBIP1, BBS2
single-organism cellular localization (GO:1902580)	3.16	11	BBS12, MKKS, IFT27, BBS1, ARL6, BBS7, BBS5, BBS4, BBS2, BBIP1, TTC21B
single-organism localization (GO:1902578)	2.09	11	BBS12, MKKS, IFT27, BBS1, ARL6, BBS7, BBS5, BBS4, BBS2, BBIP1, TTC21B
single-multicellular organism process (GO:0044707)	1.78	11	BBS10, BBS12, BBS4, MKS1, BBS1, ARL6, TTC21B, BBS7, MKKS, BBS2, TTC8
neurological system process (GO:0050877)	2.64	10	BBS10, BBS4, BBS1, ARL6, BBS7, BBS9, MKKS, BBS5, BBS2, TTC8
response to stimulus (GO:0050896)	1.22	10	BBS10, MKKS, TRIM32, BBS1, BBS7, BBS9, BBS4, BBS5, BBS2, ARL6
anatomical structure development (GO:0048856)	1.58	10	CEP290, BBS2, BBS4, MKS1, BBS7, WDPCP, TTC8, MKKS, TTC21B, ARL6
sensory perception (GO:0007600)	2.93	10	BBS10, MKKS, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBS2
single-organism transport (GO:0044765)	2.18	10	BBS12, MKKS, IFT27, BBS1, ARL6, BBS7, BBS5, BBS4, TTC21B, BBS2
anatomical structure morphogenesis (GO:0009653)	2.53	10	CEP290, MKKS, MKS1, TMEM67, BBS7, WDPCP, BBS5, BBS4, TTC21B, BBS2
system process (GO:0003008)	2.3	10	BBS10, MKKS, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS2, TTC8
cell projection morphogenesis (GO:0048858)	4.05	9	CEP290, MKKS, MKS1, TMEM67, BBS7, WDPCP, BBS4, BBS2, TTC21B
cilium morphogenesis (GO:0060271)	5.54	9	CEP290, MKKS, MKS1, TMEM67, BBS7, WDPCP, BBS4, BBS2, TTC21B
visual perception (GO:0007601)	4.41	9	BBS10, MKKS, BBS1, BBS7, BBS9, BBS4, BBS5, BBS2, ARL6
sensory perception of light stimulus (GO:0050953)	4.4	9	BBS10, MKKS, BBS1, BBS7, BBS9, BBS4, BBS5, BBS2, ARL6
cellular component morphogenesis (GO:0032989)	3.5	9	CEP290, MKKS, MKS1, TMEM67, BBS7, WDPCP, BBS4, BBS2, TTC21B
establishment of localization in cell (GO:0051649)	2.47	9	BBS12, MKKS, IFT27, BBS5, ARL6, BBS7, BBS4, TTC21B, BBS2
negative regulation of biological process (GO:0048519)	1.33	9	LZTFL1, BBS12, MKKS, TRIM32, TMEM67, BBS4, BBS2, TTC8, KIF7
cell part morphogenesis (GO:0032990)	3.99	9	CEP290, MKKS, MKS1, TMEM67, BBS7, WDPCP, BBS4, BBS2, TTC21B
regulation of localization (GO:0032879)	1.94	8	CEP290, MKKS, TRIM32, WDPCP, LZTFL1, TTC8, BBS4, BBS2
regulation of biological quality (GO:0065008)	1.68	8	BBS10, MKKS, MKS1, TRIM32, BBS1, WDPCP, BBS4, BBS2
intracellular transport (GO:0046907)	2.67	8	BBS12, MKKS, IFT27, BBS5, BBS7, BBS4, TTC21B, ARL6
cell differentiation (GO:0030154)	2.14	8	MKKS, TRIM32, BBS9, ARL6, BBS7, BBS4, TTC8, BBS2
regulation of response to stimulus (GO:0048583)	1.54	8	MKKS, MKS1, TRIM32, ARL6, BBS4, BBS2, TTC21B, KIF7
movement of cell or subcellular component (GO:0006928)	2.61	8	BBS12, IFT27, WDPCP, SDCCAG8, BBS4, TTC8, TTC21B, KIF7
signal transduction (GO:0007165)	1.28	8	MKKS, IFT27, ARL6, BBS7, WDPCP, BBS4, BBS2, TTC21B
cell surface receptor signaling pathway (GO:0007166)	2.09	8	MKKS, IFT27, ARL6, BBS7, WDPCP, BBS4, BBS2, TTC21B
fat cell differentiation (GO:0045444)	5.02	8	MKKS, TRIM32, BBS9, ARL6, BBS7, BBS4, TTC8, BBS2
regulation of cellular component organization (GO:0051128)	2.01	8	BBS10, LZTFL1, MKKS, TRIM32, TMEM67, WDPCP, BBS4, TTC8
nonmotile primary cilium assembly (GO:0035058)	6.51	7	BBS10, MKKS, MKS1, BBS1, BBS7, BBS4, BBS2
regulation of metabolic process (GO:0019222)	1.02	7	CEP290, MKKS, TRIM32, BBS7, BBS4, TTC21B, BBS2
cellular macromolecule localization (GO:0070727)	3.1	7	BBS1, ARL6, BBS9, BBS4, TTC21B, BBIP1, BBS2
regulation of macromolecule metabolic process (GO:0060255)	1.08	7	CEP290, MKKS, TRIM32, BBS7, BBS4, TTC21B, BBS2
cellular protein localization (GO:0034613)	3.11	7	BBS1, ARL6, BBS9, BBS4, TTC21B, BBIP1, BBS2
protein localization to cilium (GO:0061512)	6.43	7	BBS1, ARL6, BBS9, BBS4, TTC21B, BBIP1, BBS2
positive regulation of biological process (GO:0048518)	1.2	7	CEP290, MKKS, TRIM32, BBS7, BBS4, BBS2, KIF7
animal organ development (GO:0048513)	2.53	7	CEP290, MKS1, BBS7, WDPCP, MKKS, BBS2, ARL6
protein localization to organelle (GO:0033365)	3.57	7	BBS1, ARL6, BBS9, BBS4, TTC21B, BBIP1, BBS2
regulation of gene expression (GO:0010468)	1.37	7	CEP290, MKKS, TRIM32, BBS7, BBS4, TTC21B, BBS2
negative regulation of cellular process (GO:0048523)	1.41	7	BBS12, BBS4, TRIM32, MKKS, TMEM67, LZTFL1, KIF7
embryonic morphogenesis (GO:0048598)	3.72	6	BBS4, MKS1, BBS5, BBS7, WDPCP, MKKS
pattern specification process (GO:0007389)	3.79	6	MKS1, ARL6, BBS7, MKKS, TTC21B, TTC8
melanosome localization (GO:0032400)	6.59	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
vesicle localization (GO:0051648)	4.85	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
regulation of developmental process (GO:0050793)	2.1	6	BBS4, MKS1, TRIM32, WDPCP, MKKS, BBS2
pigment granule localization (GO:0051875)	6.55	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
pigment granule transport (GO:0051904)	6.64	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
establishment of pigment granule localization (GO:0051905)	6.59	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
microtubule-based process (GO:0007017)	3.54	6	BBS12, IFT27, BBS4, BBS2, TTC21B, KIF7
photoreceptor cell maintenance (GO:0045494)	6.17	6	BBS10, BBS12, BBS4, BBS1, MKKS, BBS2
regulation of multicellular organismal process (GO:0051239)	1.87	6	BBS4, MKS1, TRIM32, WDPCP, MKKS, BBS2
melanosome transport (GO:0032402)	6.68	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
establishment of melanosome localization (GO:0032401)	6.64	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
establishment of organelle localization (GO:0051656)	4.15	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
establishment of vesicle localization (GO:0051650)	4.91	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
organelle localization (GO:0051640)	3.94	6	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
morphogenesis of an epithelium (GO:0002009)	4.08	5	BBS7, BBS4, MKKS, MKS1, BBS5
regulation of locomotion (GO:0040012)	3.12	5	WDPCP, TRIM32, BBS4, BBS2, MKKS
tube morphogenesis (GO:0035239)	4.35	5	BBS7, BBS4, MKKS, MKS1, BBS5
regulation of primary metabolic process (GO:0080090)	1.08	5	CEP290, TRIM32, BBS7, TTC21B, BBS4
anatomical structure homeostasis (GO:0060249)	4.25	5	BBS10, TRIM32, BBS4, MKS1, BBS1
regulation of signal transduction (GO:0009966)	1.84	5	TTC21B, TRIM32, KIF7, MKS1, ARL6
negative regulation of response to stimulus (GO:0048585)	2.52	5	TRIM32, BBS2, BBS4, MKKS, KIF7
homeostatic process (GO:0042592)	2.61	5	BBS10, TRIM32, BBS4, MKS1, BBS1
regulation of cellular component biogenesis (GO:0044087)	3.08	5	BBS10, TTC8, WDPCP, BBS4, MKKS
regulation of cellular component movement (GO:0051270)	3.08	5	TRIM32, BBS2, WDPCP, BBS4, MKKS
regulation of cell motility (GO:2000145)	3.16	5	TRIM32, BBS2, WDPCP, BBS4, MKKS
tissue morphogenesis (GO:0048729)	3.87	5	BBS7, BBS4, MKKS, MKS1, BBS5
regulation of signaling (GO:0023051)	1.72	5	TTC21B, ARL6, TRIM32, KIF7, MKS1
tissue homeostasis (GO:0001894)	4.78	5	BBS10, BBS1, TRIM32, BBS4, MKS1
regulation of cell communication (GO:0010646)	1.73	5	TTC21B, TRIM32, KIF7, MKS1, ARL6
positive regulation of cellular process (GO:0048522)	1.3	5	CEP290, TRIM32, BBS7, BBS4, KIF7
regulation of smoothened signaling pathway (GO:0008589)	5.62	4	TTC21B, KIF7, MKS1, ARL6
determination of left/right symmetry (GO:0007368)	5.38	4	BBS7, MKKS, MKS1, ARL6
negative regulation of metabolic process (GO:0009892)	1.93	4	TRIM32, BBS4, BBS2, MKKS
positive regulation of growth (GO:0045927)	4.25	4	TRIM32, BBS4, BBS2, MKKS
regulation of organelle organization (GO:0033043)	2.72	4	TTC8, BBS4, MKKS, TMEM67
macromolecular complex subunit organization (GO:0043933)	2.14	4	BBS10, ARL6, BBS12, MKKS
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	4	CEP290, TRIM32, BBS7, TTC21B
regulation of cellular metabolic process (GO:0031323)	1.07	4	CEP290, TRIM32, BBS7, TTC21B
negative regulation of cellular component organization (GO:0051129)	3.35	4	LZTFL1, BBS4, MKKS, TMEM67
membrane organization (GO:0061024)	3.04	4	BBS2, BBIP1, ARL6, BBS1
negative regulation of gene expression (GO:0010629)	2.48	4	TRIM32, BBS4, BBS2, MKKS
positive regulation of developmental process (GO:0051094)	2.77	4	TRIM32, BBS4, BBS2, MKKS
cellular macromolecular complex assembly (GO:0034622)	3.18	4	BBS10, ARL6, BBS12, MKKS
specification of symmetry (GO:0009799)	5.36	4	BBS7, MKKS, MKS1, ARL6
regulation of microtubule-based process (GO:0032886)	4.79	4	BBS2, BBS4, MKKS, TMEM67
regulation of protein localization (GO:0032880)	2.88	4	CEP290, WDPCP, TTC8, LZTFL1
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	4	TRIM32, BBS4, BBS2, MKKS
protein complex subunit organization (GO:0071822)	2.6	4	BBS10, ARL6, BBS12, MKKS
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	4	CEP290, TRIM32, BBS7, TTC21B
positive regulation of multicellular organismal process (GO:0051240)	2.49	4	TRIM32, BBS4, BBS2, MKKS
regulation of cytoskeleton organization (GO:0051493)	3.72	4	TTC8, BBS4, MKKS, TMEM67
heart looping (GO:0001947)	5.65	4	BBS7, BBS4, BBS5, MKKS
macromolecular complex assembly (GO:0065003)	2.55	4	BBS10, ARL6, BBS12, MKKS
regulation of cellular biosynthetic process (GO:0031326)	1.38	4	CEP290, TRIM32, BBS7, TTC21B
epithelial tube morphogenesis (GO:0060562)	5.12	4	BBS7, BBS4, BBS5, MKKS
regulation of molecular function (GO:0065009)	1.78	4	TRIM32, TTC8, BBS4, MKKS
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	4	CEP290, TRIM32, BBS7, TTC21B
protein complex assembly (GO:0006461)	2.78	4	BBS10, ARL6, BBS12, MKKS
regulation of biosynthetic process (GO:0009889)	1.37	4	CEP290, TRIM32, BBS7, TTC21B
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	4	CEP290, TRIM32, BBS7, TTC21B
single-organism membrane organization (GO:0044802)	3.19	4	BBS2, BBIP1, ARL6, BBS1
behavior (GO:0007610)	3.47	4	BBS2, BBS12, BBS4, MKKS
regulation of RNA biosynthetic process (GO:2001141)	1.55	4	CEP290, TRIM32, BBS7, TTC21B
response to chemical (GO:0042221)	1.98	4	TRIM32, BBS4, BBS2, MKKS
cellular protein complex assembly (GO:0043623)	3.9	4	BBS10, ARL6, BBS12, MKKS
response to organic substance (GO:0010033)	2.2	4	TRIM32, BBS4, BBS2, MKKS
embryonic heart tube morphogenesis (GO:0003143)	5.57	4	BBS7, BBS4, BBS5, MKKS
single-organism intracellular transport (GO:1902582)	3.59	4	BBS12, TTC21B, IFT27, ARL6
cytoskeleton organization (GO:0007010)	3.22	4	TRIM32, WDPCP, BBS2, BBS4
smoothened signaling pathway (GO:0007224)	5.45	4	WDPCP, TTC21B, IFT27, BBS7
regulation of RNA metabolic process (GO:0051252)	1.52	4	CEP290, TRIM32, BBS7, TTC21B
microtubule-based movement (GO:0007018)	4.39	4	BBS12, TTC21B, IFT27, KIF7
regulation of growth (GO:0040008)	3.26	4	TRIM32, BBS4, BBS2, MKKS
regulation of transcription, DNA-templated (GO:0006355)	1.56	4	CEP290, TRIM32, BBS7, TTC21B
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	4	CEP290, TRIM32, BBS7, TTC21B
determination of bilateral symmetry (GO:0009855)	5.37	4	BBS7, MKKS, MKS1, ARL6
system development (GO:0048731)	2.92	4	TTC21B, WDPCP, BBS4, MKS1
intracellular protein transport (GO:0006886)	3.2	4	BBS12, ARL6, IFT27, TTC21B
protein localization to membrane (GO:0072657)	3.95	4	BBS2, BBIP1, ARL6, BBS1
positive regulation of developmental growth (GO:0048639)	4.67	3	BBS2, BBS4, MKKS
regulation of developmental growth (GO:0048638)	4.04	3	BBS2, BBS4, MKKS
regulation of response to extracellular stimulus (GO:0032104)	6.51	3	BBS2, BBS4, MKKS
negative regulation of response to extracellular stimulus (GO:0032105)	7.09	3	BBS2, BBS4, MKKS
negative regulation of response to external stimulus (GO:0032102)	4.18	3	BBS2, BBS4, MKKS
positive regulation of metabolic process (GO:0009893)	1.74	3	CEP290, TRIM32, BBS7
regulation of GTPase activity (GO:0043087)	3.21	3	TTC8, BBS4, MKKS
regulation of response to external stimulus (GO:0032101)	3.06	3	BBS2, BBS4, MKKS
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	CEP290, TRIM32, BBS7
cellular process involved in reproduction in multicellular organism (GO:0022412)	4.3	3	BBS2, BBS4, MKKS
cell development (GO:0048468)	3.28	3	CEP290, BBS4, MKKS
establishment of protein localization to membrane (GO:0090150)	4.14	3	BBS2, ARL6, BBS1
negative regulation of response to nutrient levels (GO:0032108)	7.09	3	BBS2, BBS4, MKKS
tube formation (GO:0035148)	4.98	3	SDCCAG8, BBS4, MKS1
hippocampus development (GO:0021766)	5.6	3	BBS2, BBS4, MKKS
protein localization to nonmotile primary cilium (GO:0097499)	7.43	3	ARL6, BBIP1, BBS4
cell motility (GO:0048870)	3.02	3	WDPCP, SDCCAG8, BBS4
protein localization to cell periphery (GO:1990778)	4.91	3	BBS2, BBIP1, BBS1
negative regulation of appetite by leptin-mediated signaling pathway (GO:0038108)	8.34	3	BBS2, BBS4, MKKS
regulation of hydrolase activity (GO:0051336)	2.53	3	TTC8, BBS4, MKKS
response to leptin (GO:0044321)	6.84	3	BBS2, BBS4, MKKS
cytokine-mediated signaling pathway (GO:0019221)	3.6	3	BBS2, BBS4, MKKS
response to endogenous stimulus (GO:0009719)	2.79	3	BBS2, BBS4, MKKS
regulation of actin filament bundle assembly (GO:0032231)	5.37	3	TTC8, BBS4, MKKS
retina homeostasis (GO:0001895)	6.07	3	BBS10, BBS4, BBS1
negative regulation of catalytic activity (GO:0043086)	3.0	3	TTC8, BBS4, MKKS
regulation of response to food (GO:0032095)	6.78	3	BBS2, BBS4, MKKS
negative regulation of response to food (GO:0032096)	7.24	3	BBS2, BBS4, MKKS
regulation of appetite (GO:0032098)	6.51	3	BBS2, BBS4, MKKS
negative regulation of appetite (GO:0032099)	7.24	3	BBS2, BBS4, MKKS
negative regulation of cytoskeleton organization (GO:0051494)	5.01	3	BBS4, MKKS, TMEM67
regulation of stress fiber assembly (GO:0051492)	5.49	3	TTC8, BBS4, MKKS
cytoskeleton-dependent intracellular transport (GO:0030705)	4.96	3	BBS12, TTC21B, IFT27
protein transport along microtubule (GO:0098840)	6.43	3	BBS12, TTC21B, IFT27
regulation of cilium-dependent cell motility (GO:1902019)	7.94	3	BBS2, BBS4, MKKS
negative regulation of molecular function (GO:0044092)	2.74	3	TTC8, BBS4, MKKS
regulation of actin filament-based process (GO:0032970)	3.97	3	TTC8, BBS4, MKKS
cell migration (GO:0016477)	3.12	3	WDPCP, SDCCAG8, BBS4
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	WDPCP, BBS4, MKS1
protein complex localization (GO:0031503)	5.62	3	BBS12, TTC21B, IFT27
organ morphogenesis (GO:0009887)	3.55	3	BBS2, BBS4, MKKS
sensory perception of chemical stimulus (GO:0007606)	3.49	3	TTC8, BBS4, MKKS
sensory perception of smell (GO:0007608)	3.61	3	TTC8, BBS4, MKKS
regulation of microtubule-based movement (GO:0060632)	6.78	3	BBS2, BBS4, MKKS
striatum development (GO:0021756)	7.33	3	BBS2, BBS4, MKKS
regulation of catalytic activity (GO:0050790)	1.97	3	TTC8, BBS4, MKKS
negative regulation of GTPase activity (GO:0034260)	5.99	3	TTC8, BBS4, MKKS
response to hormone (GO:0009725)	3.33	3	BBS2, BBS4, MKKS
reproductive process (GO:0022414)	2.55	3	BBS2, BBS4, MKKS
establishment of localization by movement along microtubule (GO:0010970)	5.14	3	BBS12, TTC21B, IFT27
regulation of anatomical structure size (GO:0090066)	3.78	3	BBS2, BBS4, MKKS
regulation of actin cytoskeleton organization (GO:0032956)	4.09	3	TTC8, BBS4, MKKS
cerebral cortex development (GO:0021987)	5.57	3	BBS2, BBS4, MKKS
regulation of cilium beat frequency (GO:0003356)	7.33	3	BBS2, BBS4, MKKS
regulation of protein complex assembly (GO:0043254)	3.83	3	BBS10, BBS4, MKKS
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	CEP290, TRIM32, BBS7
regulation of cilium movement (GO:0003352)	7.24	3	BBS2, BBS4, MKKS
negative regulation of hydrolase activity (GO:0051346)	3.74	3	TTC8, BBS4, MKKS
locomotion (GO:0040011)	2.91	3	WDPCP, SDCCAG8, BBS4
single organism reproductive process (GO:0044702)	2.73	3	BBS2, BBS4, MKKS
regulation of multicellular organism growth (GO:0040014)	5.48	3	BBS2, BBS4, MKKS
mitotic cell cycle process (GO:1903047)	3.12	3	CEP290, SDCCAG8, BBS4
developmental process involved in reproduction (GO:0003006)	3.36	3	BBS2, BBS4, MKKS
positive regulation of multicellular organism growth (GO:0040018)	6.17	3	BBS2, BBS4, MKKS
regulation of cell cycle (GO:0051726)	2.93	3	TRIM32, BBS4, TMEM67
regulation of cilium movement involved in cell motility (GO:0060295)	7.94	3	BBS2, BBS4, MKKS
negative regulation of organelle organization (GO:0010639)	4.07	3	BBS4, MKKS, TMEM67
regulation of cilium beat frequency involved in ciliary motility (GO:0060296)	7.94	3	BBS2, BBS4, MKKS
intraciliary transport (GO:0042073)	6.43	3	BBS12, TTC21B, IFT27
regulation of multicellular organismal development (GO:2000026)	2.31	3	TRIM32, WDPCP, MKS1
chaperone-mediated protein complex assembly (GO:0051131)	7.16	3	BBS10, BBS12, MKKS
brain morphogenesis (GO:0048854)	7.02	3	BBS2, BBS4, MKKS
cell cycle process (GO:0022402)	2.75	3	CEP290, SDCCAG8, BBS4
regulation of response to nutrient levels (GO:0032107)	6.51	3	BBS2, BBS4, MKKS
leptin-mediated signaling pathway (GO:0033210)	7.53	3	BBS2, BBS4, MKKS
primary metabolic process (GO:0044238)	0.69	2	TRIM32, TMEM67
G2/M transition of mitotic cell cycle (GO:0000086)	4.84	2	CEP290, SDCCAG8
positive regulation of response to stimulus (GO:0048584)	2.18	2	TRIM32, KIF7
regulation of actin polymerization or depolymerization (GO:0008064)	4.65	2	BBS4, MKKS
plasma membrane organization (GO:0007009)	4.8	2	BBS2, BBS1
circulatory system process (GO:0003013)	4.38	2	BBS2, MKKS
face development (GO:0060324)	6.78	2	BBS4, MKKS
vascular process in circulatory system (GO:0003018)	4.65	2	BBS2, MKKS
regulation of cell projection organization (GO:0031344)	3.38	2	WDPCP, BBS4
ventricular system development (GO:0021591)	7.02	2	TTC21B, BBS4
negative regulation of signal transduction (GO:0009968)	2.75	2	TRIM32, KIF7
positive regulation of signal transduction (GO:0009967)	2.5	2	TRIM32, KIF7
kidney development (GO:0001822)	4.79	2	CEP290, WDPCP
protein localization to ciliary membrane (GO:1903441)	7.94	2	BBS2, BBIP1
vascular smooth muscle contraction (GO:0014829)	7.16	2	BBS2, MKKS
muscle contraction (GO:0006936)	4.37	2	BBS2, MKKS
social behavior (GO:0035176)	5.9	2	BBS4, MKKS
tonic smooth muscle contraction (GO:0014820)	7.43	2	BBS2, MKKS
centrosome organization (GO:0051297)	5.38	2	SDCCAG8, BBS4
artery smooth muscle contraction (GO:0014824)	7.53	2	BBS2, MKKS
germ cell development (GO:0007281)	4.75	2	BBS4, MKKS
regulation of proteolysis (GO:0030162)	3.2	2	TRIM32, BBS7
regulation of embryonic development (GO:0045995)	4.98	2	WDPCP, MKS1
spermatid development (GO:0007286)	5.32	2	BBS4, MKKS
intraspecies interaction between organisms (GO:0051703)	5.9	2	BBS4, MKKS
protein localization to plasma membrane (GO:0072659)	5.29	2	BBS2, BBS1
multi-organism behavior (GO:0051705)	5.6	2	BBS4, MKKS
multi-organism process (GO:0051704)	2.65	2	BBS4, MKKS
positive regulation of signaling (GO:0023056)	2.41	2	TRIM32, KIF7
cartilage development (GO:0051216)	5.31	2	BBS2, MKKS
protein metabolic process (GO:0019538)	1.45	2	TRIM32, TMEM67
single-organism behavior (GO:0044708)	3.79	2	BBS2, BBS4
regulation of cell projection assembly (GO:0060491)	4.66	2	WDPCP, BBS4
regulation of cellular component size (GO:0032535)	4.21	2	BBS4, MKKS
positive regulation of catabolic process (GO:0009896)	3.94	2	TRIM32, BBS7
regulation of catabolic process (GO:0009894)	3.52	2	TRIM32, BBS7
embryonic organ development (GO:0048568)	4.86	2	WDPCP, MKS1
microtubule cytoskeleton organization (GO:0000226)	4.13	2	BBS2, BBS4
neuron projection development (GO:0031175)	4.58	2	TRIM32, BBS4
vasoconstriction (GO:0042310)	6.36	2	BBS2, MKKS
vasodilation (GO:0042311)	6.68	2	BBS2, MKKS
intracellular signal transduction (GO:0035556)	2.39	2	ARL6, IFT27
cellular macromolecule metabolic process (GO:0044260)	0.93	2	TRIM32, TMEM67
establishment of protein localization to plasma membrane (GO:0090002)	5.2	2	BBS2, BBS1
pigment granule aggregation in cell center (GO:0051877)	9.04	2	BBS7, MKKS
neural tube closure (GO:0001843)	5.38	2	BBS4, MKS1
regulation of tube size (GO:0035150)	4.79	2	BBS2, MKKS
tissue development (GO:0009888)	3.27	2	TTC8, BBS4
tube closure (GO:0060606)	5.36	2	BBS4, MKS1
metabolic process (GO:0008152)	0.58	2	TRIM32, TMEM67
positive regulation of proteolysis (GO:0045862)	3.86	2	TRIM32, BBS7
embryonic digit morphogenesis (GO:0042733)	5.69	2	WDPCP, MKS1
brain development (GO:0007420)	4.24	2	BBS7, ARL6
sensory organ development (GO:0007423)	4.82	2	BBS7, WDPCP
cognition (GO:0050890)	4.2	2	TTC8, BBS4
sensory processing (GO:0050893)	8.63	2	TTC8, BBS4
positive regulation of protein catabolic process (GO:0045732)	4.18	2	TRIM32, BBS7
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	2	TTC21B, BBS7
regulation of cell morphogenesis (GO:0022604)	3.4	2	WDPCP, BBS4
regulation of cell cycle process (GO:0010564)	3.5	2	BBS4, TMEM67
regulation of cellular protein localization (GO:1903827)	3.43	2	CEP290, LZTFL1
negative regulation of signaling (GO:0023057)	2.65	2	TRIM32, KIF7
regulation of protein catabolic process (GO:0042176)	3.83	2	TRIM32, BBS7
negative regulation of cell communication (GO:0010648)	2.66	2	TRIM32, KIF7
positive regulation of cell communication (GO:0010647)	2.41	2	TRIM32, KIF7
regulation of blood vessel size (GO:0050880)	4.8	2	BBS2, MKKS
cell cycle G2/M phase transition (GO:0044839)	4.82	2	CEP290, SDCCAG8
regulation of protein metabolic process (GO:0051246)	1.93	2	TRIM32, BBS7
positive regulation of protein metabolic process (GO:0051247)	2.43	2	TRIM32, BBS7
Golgi to plasma membrane protein transport (GO:0043001)	6.43	2	BBS2, BBS1
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	TRIM32, BBS7
regulation of protein polymerization (GO:0032271)	4.57	2	BBS4, MKKS
negative regulation of protein polymerization (GO:0032272)	5.72	2	BBS4, MKKS
microtubule organizing center organization (GO:0031023)	5.26	2	SDCCAG8, BBS4
adult behavior (GO:0030534)	4.79	2	BBS2, BBS4
negative regulation of protein complex assembly (GO:0031333)	5.07	2	BBS4, MKKS
regulation of cell differentiation (GO:0045595)	2.42	2	TRIM32, BBS12
eye development (GO:0001654)	5.07	2	BBS7, WDPCP
regulation of cellular protein metabolic process (GO:0032268)	1.99	2	TRIM32, BBS7
macromolecule metabolic process (GO:0043170)	0.83	2	TRIM32, TMEM67
neuron migration (GO:0001764)	5.0	2	SDCCAG8, BBS4
heart development (GO:0007507)	4.24	2	BBS7, MKKS
regulation of cellular localization (GO:0060341)	3.03	2	CEP290, LZTFL1
palate development (GO:0060021)	5.38	2	BBS7, WDPCP
cell cycle phase transition (GO:0044770)	4.24	2	CEP290, SDCCAG8
mitotic cell cycle phase transition (GO:0044772)	4.27	2	CEP290, SDCCAG8
regulation of blood pressure (GO:0008217)	4.72	2	BBS4, MKKS
eye photoreceptor cell development (GO:0042462)	6.23	2	CEP290, BBS4
regulation of actin filament length (GO:0030832)	4.65	2	BBS4, MKKS
regulation of actin filament polymerization (GO:0030833)	4.76	2	BBS4, MKKS
negative regulation of actin filament polymerization (GO:0030837)	5.94	2	BBS4, MKKS
organic substance metabolic process (GO:0071704)	0.63	2	TRIM32, TMEM67
muscle system process (GO:0003012)	4.18	2	BBS2, MKKS
regulation of nervous system development (GO:0051960)	3.1	2	TRIM32, MKS1
smooth muscle contraction (GO:0006939)	5.9	2	BBS2, MKKS
neuron development (GO:0048666)	4.8	2	CEP290, BBS4
regulation of cell migration (GO:0030334)	3.23	2	TRIM32, WDPCP
photoreceptor cell development (GO:0042461)	6.17	2	CEP290, BBS4
tube development (GO:0035295)	4.41	2	TTC8, MKS1
small GTPase mediated signal transduction (GO:0007264)	3.85	2	ARL6, IFT27
response to abiotic stimulus (GO:0009628)	2.8	2	TRIM32, MKKS
negative regulation of blood pressure (GO:0045776)	5.99	2	BBS4, MKKS
cellular metabolic process (GO:0044237)	0.69	2	TRIM32, TMEM67

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
establishment of organelle localization (GO:0051656)	-	4.15	0.001	MKKS, BBS5, BBS7, BBS1, BBS4, BBS2, ARL6
establishment of vesicle localization (GO:0051650)	-	4.91	0.0	MKKS, BBS5, BBS7, BBS1, BBS4, BBS2, ARL6
cellular component organization or biogenesis (GO:0071840)	-	1.22	0.0	BBS10, CEP290, BBS12, MKKS, MKS1, CCDC28B, BBS9, ARL6, BBS7, WDPCP, BBS1, BBS4, BBS5, TTC8, BBIP1, BBS2, TMEM67
cellular response to leptin stimulus (GO:0044320)	NEW	7.53	0.0	BBS2, BBS7, BBS4, MKKS
cellular developmental process (GO:0048869)	-	1.82	0.004	CEP290, MKKS, MKS1, TRIM32, TMEM67, ARL6, BBS7, WDPCP, BBS9, BBS4, TTC8, BBS2
determination of left/right symmetry (GO:0007368)	-	5.38	0.019	BBS7, ARL6, MKKS
vascular smooth muscle contraction (GO:0014829)	-	7.16	0.003	BBS2, BBS7, MKKS
sensory perception of smell (GO:0007608)	-	3.61	0.033	TTC8, BBS4, BBS7, MKKS
tonic smooth muscle contraction (GO:0014820)	-	7.43	0.025	BBS2, BBS7, MKKS
visual perception (GO:0007601)	-	4.41	0.0	BBS10, LZTFL1, MKKS, BBS1, BBS7, BBS9, BBS4, BBS5, BBS2, ARL6
sensory perception (GO:0007600)	-	2.93	0.0	BBS10, CEP290, LZTFL1, IFT27, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, MKKS, TTC8, BBS2
establishment of protein localization (GO:0045184)	-	2.53	0.0	CEP290, TTC8, BBS4, IFT27, BBS1, BBS7, WDPCP, BBS9, LZTFL1, BBS5, ARL6, BBIP1, BBS2
microtubule-based transport (GO:0010970)	-	5.14	0.006	CEP290, BBS2, BBS12, TTC21B, BBS1
negative regulation of response to nutrient levels (GO:0032108)	-	7.09	0.0	BBS2, BBS7, BBS4, MKKS
regulation of cilium movement (GO:0003352)	-	7.24	0.0	BBS2, BBS7, BBS4, MKKS
system process (GO:0003008)	-	2.3	0.0	BBS10, MKKS, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS2, TTC8
single-multicellular organism process (GO:0044707)	-	1.78	0.01	BBS10, BBS2, BBS4, MKS1, BBS1, ARL6, BBS7, BBS9, MKKS, BBS5, BBS12, TTC8, TTC21B
cilium organization (GO:0044782)	-	4.67	0.0	BBS10, CEP290, MKKS, MKS1, CCDC28B, IFT27, BBS1, ARL6, BBS7, WDPCP, BBS9, LZTFL1, BBS5, BBS4, BBS2, BBIP1, TTC8, SDCCAG8, TMEM67
photoreceptor cell maintenance (GO:0045494)	-	6.17	0.0	BBS10, BBS12, MKKS, BBS1, BBS7, BBS4, BBS2
cellular component assembly (GO:0022607)	-	2.14	0.0	BBS9, BBS10, CEP290, BBS2, MKKS, MKS1, CCDC28B, BBS1, BBS7, WDPCP, TMEM67, BBS4, BBS5, BBS12, TTC8, BBIP1, ARL6
vasoconstriction (GO:0042310)	-	6.36	0.05	BBS2, BBS7, MKKS
vasodilation (GO:0042311)	-	6.68	0.048	BBS2, BBS7, MKKS
anatomical structure morphogenesis (GO:0009653)	-	2.53	0.008	CEP290, MKKS, MKS1, BBS5, BBS7, WDPCP, TMEM67, BBS4, BBS2
regulation of response to food (GO:0032095)	-	6.78	0.0	BBS2, BBS7, BBS4, MKKS
negative regulation of response to food (GO:0032096)	-	7.24	0.0	BBS2, BBS7, BBS4, MKKS
regulation of appetite (GO:0032098)	-	6.51	0.0	BBS2, BBS7, BBS4, MKKS
negative regulation of appetite (GO:0032099)	-	7.24	0.0	BBS2, BBS7, BBS4, MKKS
cellular component organization (GO:0016043)	-	1.24	0.0	BBS10, CEP290, BBS12, BBS4, MKS1, CCDC28B, BBS1, ARL6, BBS7, WDPCP, BBS9, MKKS, BBS5, BBS2, BBIP1, TTC8, TMEM67
pigment granule aggregation in cell center (GO:0051877)	-	9.04	0.0	BBS7, BBS4, MKKS
regulation of cilium-dependent cell motility (GO:1902019)	-	7.94	0.0	BBS2, BBS7, BBS4, MKKS
response to leptin (GO:0044321)	-	6.84	0.0	BBS2, BBS7, BBS4, MKKS
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.0	BBS10, CEP290, MKKS, MKS1, CCDC28B, IFT27, BBS1, ARL6, BBS7, WDPCP, BBS9, LZTFL1, BBS5, BBS4, BBS2, BBIP1, TTC8, SDCCAG8, TMEM67
chaperone-mediated protein complex assembly (GO:0051131)	-	7.16	0.0	BBS10, BBS7, BBS12, MKKS
cilium assembly (GO:0042384)	-	4.77	0.0	BBS9, BBS10, CEP290, TTC8, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS7, WDPCP, TMEM67, LZTFL1, BBS5, BBS4, ARL6, BBIP1, BBS2, SDCCAG8
cilium morphogenesis (GO:0060271)	-	5.54	0.0	CEP290, MKKS, MKS1, TMEM67, BBS7, WDPCP, BBS4, BBS2
sensory perception of light stimulus (GO:0050953)	-	4.4	0.0	BBS10, LZTFL1, MKKS, BBS1, BBS7, BBS9, BBS4, BBS5, BBS2, ARL6
establishment of localization (GO:0051234)	-	1.48	0.003	CEP290, LZTFL1, BBS12, MKKS, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2
smoothened signaling pathway (GO:0007224)	-	5.45	0.001	CEP290, TTC21B, WDPCP, BBS7, KIF7
sensory processing (GO:0050893)	-	8.63	0.01	TTC8, BBS4
regulation of response to nutrient levels (GO:0032107)	-	6.51	0.016	BBS2, BBS7, BBS4, MKKS
regulation of response to extracellular stimulus (GO:0032104)	-	6.51	0.016	BBS2, BBS7, BBS4, MKKS
negative regulation of response to extracellular stimulus (GO:0032105)	-	7.09	0.0	BBS2, BBS7, BBS4, MKKS
intraciliary transport (GO:0042073)	-	6.43	0.0	TTC21B, BBS12, CEP290, BBS1
cellular component assembly involved in morphogenesis (GO:0010927)	-	4.29	0.0	BBS9, BBS10, CEP290, TTC8, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS7, WDPCP, TMEM67, LZTFL1, BBS5, BBS4, ARL6, BBIP1, BBS2, SDCCAG8
hippocampus development (GO:0021766)	-	5.6	0.01	BBS2, BBS7, BBS4, MKKS
specification of symmetry (GO:0009799)	-	5.36	0.023	BBS7, ARL6, MKKS
regulation of microtubule-based process (GO:0032886)	-	4.79	0.001	CEP290, MKKS, TMEM67, BBS7, BBS4, BBS2
heart looping (GO:0001947)	-	5.65	0.001	BBS7, BBS2, BBS4, BBS5, MKKS
cytoskeleton-dependent intracellular transport (GO:0030705)	-	4.96	0.008	CEP290, BBS2, BBS12, TTC21B, BBS1
cell projection organization (GO:0030030)	-	3.14	0.0	BBS10, CEP290, LZTFL1, MKS1, CCDC28B, IFT27, BBS1, ARL6, BBS7, WDPCP, BBS9, BBS4, BBS5, MKKS, BBS2, BBIP1, TTC8, SDCCAG8, TMEM67
cell projection assembly (GO:0030031)	-	4.19	0.0	BBS9, BBS10, CEP290, TTC8, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS7, WDPCP, TMEM67, LZTFL1, BBS5, BBS4, ARL6, BBIP1, BBS2, SDCCAG8
epithelial tube morphogenesis (GO:0060562)	-	5.12	0.001	BBS4, BBS5, BBS7, BBS1, MKKS, BBS2
establishment of melanosome localization (GO:0032401)	-	6.64	0.0	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
motile cilium assembly (GO:0044458)	NEW	7.02	0.045	BBS5, BBS1
developmental process (GO:0032502)	-	1.36	0.0	BBS10, CEP290, TTC8, MKKS, MKS1, CCDC28B, TMEM67, ARL6, TTC21B, BBS7, WDPCP, BBS1, BBS4, BBS5, KIF7, BBS9, BBS2, BBIP1, TRIM32, SDCCAG8
leptin-mediated signaling pathway (GO:0033210)	-	7.53	0.0	BBS2, BBS7, BBS4, MKKS
multicellular organismal process (GO:0032501)	-	1.45	0.012	BBS10, BBS2, MKKS, MKS1, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS12, TTC21B, TTC8
tube morphogenesis (GO:0035239)	-	4.35	0.003	BBS4, BBS5, BBS7, BBS1, MKKS, BBS2
neurological system process (GO:0050877)	-	2.64	0.0	BBS10, CEP290, TTC8, LZTFL1, TRIM32, IFT27, BBS1, BBS7, BBS9, MKKS, BBS5, ARL6, BBS4, BBS2
melanosome transport (GO:0032402)	-	6.68	0.0	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
retina homeostasis (GO:0001895)	-	6.07	0.009	BBS10, BBS4, BBS1
cell part morphogenesis (GO:0032990)	-	3.99	0.0	CEP290, MKKS, MKS1, IFT27, TMEM67, BBS7, WDPCP, BBS4, BBS2
regulation of cilium movement involved in cell motility (GO:0060295)	-	7.94	0.0	BBS2, BBS7, BBS4, MKKS
regulation of cilium beat frequency involved in ciliary motility (GO:0060296)	-	7.94	0.0	BBS2, BBS7, BBS4, MKKS
establishment of pigment granule localization (GO:0051905)	-	6.59	0.0	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
pigment granule transport (GO:0051904)	-	6.64	0.0	BBS4, BBS5, BBS7, MKKS, BBS2, ARL6
positive regulation of multicellular organism growth (GO:0040018)	-	6.17	0.006	BBS2, BBS7, BBS4, MKKS
positive regulation of growth (GO:0045927)	-	4.25	0.031	TRIM32, BBS4, BBS2, MKKS
convergent extension (GO:0060026)	NEW	7.16	0.005	BBS7, BBS4, MKKS
convergent extension involved in gastrulation (GO:0060027)	NEW	7.94	0.003	BBS7, BBS4, MKKS
regulation of microtubule-based movement (GO:0060632)	-	6.78	0.0	BBS2, BBS7, BBS4, MKKS
fat cell differentiation (GO:0045444)	-	5.02	0.0	LZTFL1, TTC8, MKKS, TRIM32, BBS1, BBS7, BBS9, BBS4, ARL6, BBS2
negative regulation of appetite by leptin-mediated signaling pathway (GO:0038108)	-	8.34	0.0	BBS2, BBS7, BBS4, MKKS
cerebral cortex development (GO:0021987)	-	5.57	0.012	BBS2, BBS7, BBS4, MKKS
morphogenesis of an epithelium (GO:0002009)	-	4.08	0.017	BBS7, BBS4, MKKS, MKS1, BBS5
cellular component morphogenesis (GO:0032989)	-	3.5	0.006	CEP290, MKKS, MKS1, TRIM32, IFT27, TMEM67, BBS7, WDPCP, BBS4, BBS2
tissue morphogenesis (GO:0048729)	-	3.87	0.04	MKKS, MKS1, TRIM32, BBS1, BBS7, BBS5, BBS4, BBS2
organic substance transport (GO:0071702)	-	2.15	0.02	CEP290, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2
nonmotile primary cilium assembly (GO:0035058)	-	6.51	0.0	BBS10, MKKS, BBS1, BBS7, BBS4, TTC8, BBS2
striatum development (GO:0021756)	-	7.33	0.0	BBS2, BBS7, BBS4, MKKS
artery smooth muscle contraction (GO:0014824)	-	7.53	0.0	BBS2, BBS7, MKKS
single-organism developmental process (GO:0044767)	-	1.49	0.0	BBS10, CEP290, TTC8, MKKS, MKS1, CCDC28B, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, BBS2, BBIP1, TRIM32, SDCCAG8, TMEM67
single-organism cellular process (GO:0044763)	-	0.65	0.039	BBS10, CEP290, TTC8, MKKS, MKS1, TRIM32, BBS1, TMEM67, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, KIF7, BBS12, BBS2, BBIP1, ARL6, SDCCAG8, CCDC28B
establishment of localization in cell (GO:0051649)	-	2.47	0.049	BBS12, MKKS, BBS1, ARL6, BBS7, BBS5, BBS4, TTC21B, BBS2
organelle assembly (GO:0070925)	-	3.75	0.0	BBS10, CEP290, TTC8, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS7, WDPCP, BBS9, LZTFL1, BBS5, BBS4, ARL6, BBIP1, BBS2, SDCCAG8, TMEM67
cellular protein complex assembly (GO:0043623)	-	3.9	0.002	BBS10, BBS12, TRIM32, BBS1, BBS7, MKKS, BBS2, ARL6
localization (GO:0051179)	-	1.4	0.007	CEP290, BBS12, MKKS, BBS4, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, LZTFL1, BBS5, BBS2, BBIP1, TTC8
embryonic heart tube morphogenesis (GO:0003143)	-	5.57	0.001	BBS4, BBS5, BBS7, BBS1, MKKS, BBS2
microtubule-based process (GO:0007017)	-	3.54	0.028	CEP290, BBS12, BBS1, BBS7, BBS4, TTC21B, BBS2, KIF7
cell projection morphogenesis (GO:0048858)	-	4.05	0.0	CEP290, MKKS, MKS1, IFT27, TMEM67, BBS7, WDPCP, BBS4, BBS2
brain morphogenesis (GO:0048854)	-	7.02	0.0	BBS2, BBS7, BBS4, MKKS
microtubule-based movement (GO:0007018)	-	4.39	0.012	CEP290, BBS12, BBS1, TTC21B, BBS2, KIF7
determination of bilateral symmetry (GO:0009855)	-	5.37	0.021	BBS7, ARL6, MKKS
protein transport (GO:0015031)	-	2.62	0.0	CEP290, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	23	BBS10, BBS12, MKS1, TMEM67, BBS4, BBS2, KIF7, CCDC28B, IFT27, BBS5, WDPCP, SDCCAG8, LZTFL1, ARL6, TRIM32, BBS9, BBS7, MKKS, TTC21B, BBIP1, CEP290, BBS1, TTC8
organelle (GO:0043226)	0.4	22	BBS10, BBS12, MKS1, TMEM67, BBS4, TTC21B, KIF7, CCDC28B, IFT27, BBS5, WDPCP, SDCCAG8, ARL6, TRIM32, BBS9, BBS7, MKKS, BBS2, BBIP1, CEP290, BBS1, TTC8
intracellular part (GO:0044424)	0.28	21	CEP290, TTC8, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS9, TTC21B, BBS7, BBS4, TRIM32, TMEM67, LZTFL1, BBS5, KIF7, WDPCP, ARL6, BBIP1, BBS2, SDCCAG8
organelle part (GO:0044422)	0.79	20	CEP290, BBS2, MKKS, MKS1, TRIM32, IFT27, BBS1, ARL6, BBS7, WDPCP, BBS9, CCDC28B, BBS5, KIF7, BBS4, TTC21B, BBIP1, TTC8, SDCCAG8, TMEM67
intracellular organelle part (GO:0044446)	0.81	19	CEP290, BBS2, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS9, TTC21B, BBS7, WDPCP, TMEM67, BBS4, BBS5, KIF7, TRIM32, TTC8, ARL6, SDCCAG8
cytoplasm (GO:0005737)	1.01	19	BBS9, CEP290, TRIM32, MKS1, CCDC28B, MKKS, BBS1, ARL6, TTC21B, BBS7, WDPCP, TMEM67, LZTFL1, BBS5, BBS4, TTC8, BBIP1, BBS2, SDCCAG8
cell projection (GO:0042995)	2.47	19	BBS10, CEP290, TTC8, MKKS, MKS1, IFT27, BBS1, TMEM67, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, BBS12, ARL6, BBIP1, BBS2, KIF7
cilium (GO:0005929)	3.89	19	BBS10, CEP290, BBS2, BBS4, MKS1, IFT27, BBS1, ARL6, BBS7, WDPCP, BBS9, MKKS, BBS5, BBS12, TTC21B, BBIP1, TTC8, KIF7, TMEM67
intracellular organelle (GO:0043229)	0.51	18	CEP290, BBS2, MKKS, MKS1, TRIM32, IFT27, BBS9, TTC21B, BBS7, WDPCP, BBS1, BBS4, BBS5, TTC8, TMEM67, ARL6, SDCCAG8, CCDC28B
cytoskeletal part (GO:0044430)	2.49	18	CEP290, TTC8, BBS4, MKS1, CCDC28B, IFT27, BBS1, ARL6, BBS7, WDPCP, BBS9, MKKS, BBS5, KIF7, BBS2, TRIM32, SDCCAG8, TMEM67
cell projection part (GO:0044463)	2.97	17	BBS9, CEP290, BBS2, MKKS, MKS1, IFT27, BBS1, TTC21B, BBS7, WDPCP, TMEM67, BBS4, BBS5, TTC8, BBIP1, ARL6, KIF7
cytoplasmic part (GO:0044444)	0.82	17	CEP290, LZTFL1, MKS1, TRIM32, MKKS, BBS1, TMEM67, ARL6, BBS7, WDPCP, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2, SDCCAG8
non-membrane-bounded organelle (GO:0043228)	1.76	17	CEP290, TTC8, BBS4, MKS1, CCDC28B, IFT27, BBS1, ARL6, BBS7, WDPCP, BBS9, MKKS, BBS5, BBS2, TTC21B, SDCCAG8, TMEM67
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	17	CEP290, TTC8, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS7, BBS2, BBS9, BBS4, BBS5, WDPCP, ARL6, TTC21B, SDCCAG8, TMEM67
ciliary part (GO:0044441)	4.05	17	BBS9, CEP290, BBS4, MKS1, IFT27, BBS1, ARL6, TTC21B, BBS7, WDPCP, TMEM67, MKKS, BBS5, BBS2, BBIP1, TTC8, KIF7
protein complex (GO:0043234)	1.51	16	CEP290, TTC8, MKS1, TRIM32, IFT27, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS2, BBIP1, TTC21B, KIF7, TMEM67
cytoskeleton (GO:0005856)	2.55	16	CEP290, MKKS, MKS1, CCDC28B, BBS1, ARL6, TTC21B, BBS7, WDPCP, BBS9, BBS4, BBS5, TTC8, BBS2, SDCCAG8, TMEM67
macromolecular complex (GO:0032991)	1.35	16	BBS9, CEP290, MKS1, TRIM32, IFT27, BBS1, ARL6, TTC21B, BBS7, TMEM67, BBS4, BBS5, TTC8, BBIP1, BBS2, KIF7
cytosol (GO:0005829)	1.68	15	CEP290, LZTFL1, MKS1, TRIM32, MKKS, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, BBS2, BBIP1, TTC8, SDCCAG8
membrane (GO:0016020)	0.68	14	CEP290, LZTFL1, MKKS, MKS1, BBS1, ARL6, BBS7, WDPCP, BBS9, BBS4, BBS5, TTC8, BBS2, TMEM67
microtubule organizing center (GO:0005815)	3.42	14	BBS9, CEP290, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS7, TMEM67, BBS4, BBS5, TTC8, BBS2, SDCCAG8
membrane part (GO:0044425)	0.95	12	LZTFL1, MKKS, BBS1, ARL6, BBS7, WDPCP, BBS9, BBS4, BBS5, TTC8, BBS2, TMEM67
centrosome (GO:0005813)	3.75	11	CEP290, MKKS, MKS1, CCDC28B, IFT27, BBS1, BBS7, TMEM67, BBS4, TTC8, SDCCAG8
plasma membrane region (GO:0098590)	2.97	10	BBS9, BBS1, ARL6, BBS7, WDPCP, TMEM67, BBS4, BBS5, BBS2, TTC8
plasma membrane part (GO:0044459)	1.95	10	BBS9, BBS1, ARL6, BBS7, WDPCP, TMEM67, BBS4, BBS5, TTC8, BBS2
plasma membrane (GO:0005886)	1.39	10	BBS9, BBS1, ARL6, BBS7, WDPCP, TMEM67, BBS4, BBS5, BBS2, TTC8
ciliary membrane (GO:0060170)	5.43	9	BBS9, BBS1, ARL6, BBS7, TMEM67, BBS4, BBS5, TTC8, BBS2
bounding membrane of organelle (GO:0098588)	2.39	9	BBS9, BBS1, ARL6, BBS7, TMEM67, BBS4, BBS5, BBS2, TTC8
cell projection membrane (GO:0031253)	4.11	9	BBS9, BBS1, ARL6, BBS7, TMEM67, BBS4, BBS5, TTC8, BBS2
organelle membrane (GO:0031090)	1.97	9	BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBS2, TMEM67
BBSome (GO:0034464)	7.5	9	BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2
ciliary basal body (GO:0036064)	5.36	8	MKKS, MKS1, BBS5, BBS7, BBS1, BBS4, TTC8, BBS2
primary cilium (GO:0072372)	4.64	7	CEP290, IFT27, ARL6, BBS7, BBS4, TTC21B, TTC8
membrane-bounded organelle (GO:0043227)	0.47	6	CEP290, TRIM32, TMEM67, BBS7, BBS4, ARL6
ciliary transition zone (GO:0035869)	6.62	5	CEP290, BBS4, MKS1, BBS9, TMEM67
intracellular (GO:0005622)	2.37	5	TRIM32, IFT27, BBS5, MKKS, ARL6
intracellular membrane-bounded organelle (GO:0043231)	0.6	5	CEP290, TRIM32, BBS7, BBS4, TMEM67
microtubule organizing center part (GO:0044450)	4.8	5	CEP290, SDCCAG8, BBS4, MKS1, BBS9
centriolar satellite (GO:0034451)	6.58	4	CEP290, SDCCAG8, BBS4, BBS9
motile cilium (GO:0031514)	5.36	4	BBS2, IFT27, BBS4, MKKS
integral component of membrane (GO:0016021)	1.14	4	LZTFL1, BBS4, MKKS, TMEM67
centriole (GO:0005814)	5.15	4	CEP290, SDCCAG8, BBS4, MKS1
axoneme (GO:0005930)	5.53	4	BBS7, WDPCP, ARL6, BBS1
nonmotile primary cilium (GO:0031513)	5.14	4	CEP290, TTC8, BBS7, BBS4
nucleus (GO:0005634)	1.07	4	CEP290, TRIM32, BBS7, BBS4
intrinsic component of membrane (GO:0031224)	1.13	4	LZTFL1, BBS4, MKKS, TMEM67
ciliary tip (GO:0097542)	6.04	3	TTC21B, IFT27, KIF7
photoreceptor connecting cilium (GO:0032391)	6.28	3	CEP290, TTC8, BBS4
MKS complex (GO:0036038)	7.32	3	CEP290, MKS1, TMEM67
neuron part (GO:0097458)	2.64	3	BBS7, BBS4, MKKS
pericentriolar material (GO:0000242)	6.91	2	BBS4, BBS9
supramolecular fiber (GO:0099512)	3.31	2	ARL6, KIF7
polymeric cytoskeletal fiber (GO:0099513)	3.31	2	ARL6, KIF7
axoneme part (GO:0044447)	6.67	2	ARL6, WDPCP
microtubule (GO:0005874)	3.81	2	ARL6, KIF7
photoreceptor outer segment (GO:0001750)	5.78	2	BBS7, BBS4

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
plasma membrane region (GO:0098590)	-	2.97	0.0	BBS9, CEP290, LZTFL1, BBS1, ARL6, BBS7, TMEM67, BBS4, BBS5, BBS2, TTC8
ciliary membrane (GO:0060170)	-	5.43	0.0	CEP290, BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBS2, TMEM67
non-membrane-bounded organelle (GO:0043228)	-	1.76	0.0	CEP290, MKKS, MKS1, CCDC28B, IFT27, TMEM67, BBS7, WDPCP, BBS4, TTC21B, TTC8, SDCCAG8
cilium (GO:0005929)	-	3.89	0.0	BBS10, CEP290, LZTFL1, BBS2, MKKS, IFT27, BBS9, BBS7, BBS4, BBS12, TTC21B, BBIP1, TTC8, KIF7
nonmotile primary cilium (GO:0031513)	-	5.14	0.007	CEP290, TTC8, BBS4
ciliary basal body (GO:0036064)	-	5.36	0.0	CEP290, MKS1, BBS5, BBS7, BBS1, BBS4, BBS2, TTC8
primary cilium (GO:0072372)	-	4.64	0.02	TTC8, CEP290, BBS4
motile cilium (GO:0031514)	-	5.36	0.0	CEP290, MKKS, IFT27, BBS7, BBS4, BBS2
centrosome (GO:0005813)	-	3.75	0.0	CEP290, MKKS, MKS1, CCDC28B, IFT27, TMEM67, BBS7, BBS4, TTC8, SDCCAG8
centriole (GO:0005814)	-	5.15	0.008	CEP290, SDCCAG8, BBS4, MKS1
microtubule organizing center (GO:0005815)	-	3.42	0.0	CEP290, LZTFL1, MKS1, CCDC28B, IFT27, BBS1, BBS7, BBS9, BBS4, BBS5, MKKS, BBS2, TTC8, SDCCAG8, TMEM67
cytoskeletal part (GO:0044430)	-	2.49	0.0	CEP290, TTC8, MKKS, MKS1, CCDC28B, IFT27, BBS1, ARL6, BBS7, BBS9, LZTFL1, BBS5, KIF7, BBS2, BBS4, TRIM32, SDCCAG8, TMEM67
microtubule organizing center part (GO:0044450)	-	4.8	0.001	CEP290, SDCCAG8, BBS4, MKS1
photoreceptor connecting cilium (GO:0032391)	-	6.28	0.041	TTC8, CEP290
centriolar satellite (GO:0034451)	-	6.58	0.014	CEP290, BBS4
bounding membrane of organelle (GO:0098588)	-	2.39	0.03	BBS9, BBS1, ARL6, BBS7, TMEM67, BBS4, BBS5, BBS2, TTC8
membrane region (GO:0098589)	NEW	3.95	0.001	BBS1, ARL6, BBS7, BBS9, BBS4, BBS5, TTC8, BBS2, TMEM67
cell projection membrane (GO:0031253)	-	4.11	0.0	BBS9, CEP290, LZTFL1, TRIM32, BBS1, ARL6, BBS7, TMEM67, BBS4, BBS5, BBS2, TTC8
cell projection (GO:0042995)	-	2.47	0.0	BBS10, CEP290, LZTFL1, BBS2, MKKS, IFT27, TMEM67, BBS7, BBS9, BBS4, KIF7, BBS12, TTC21B, BBIP1, TTC8, SDCCAG8
axoneme (GO:0005930)	-	5.53	0.002	BBS7, WDPCP, ARL6
protein complex (GO:0043234)	-	1.51	0.02	BBS10, CEP290, BBS2, LZTFL1, MKS1, TRIM32, IFT27, BBS1, BBS9, TTC21B, BBS7, TMEM67, BBS4, BBS5, KIF7, TTC8, BBIP1, ARL6, SDCCAG8
TCTN-B9D complex (GO:0036038)	-	7.32	0.0	CEP290, MKS1, TMEM67
macromolecular complex (GO:0032991)	-	1.35	0.0	CEP290, BBS2, LZTFL1, MKS1, TRIM32, IFT27, BBS1, TTC21B, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1, ARL6, KIF7, TMEM67
intracellular non-membrane-bounded organelle (GO:0043232)	-	1.76	0.0	CEP290, MKKS, MKS1, CCDC28B, IFT27, TMEM67, BBS7, WDPCP, BBS4, TTC21B, TTC8, SDCCAG8
cell projection part (GO:0044463)	-	2.97	0.0	CEP290, BBS2, LZTFL1, MKS1, TRIM32, IFT27, BBS1, BBS7, WDPCP, BBS9, BBS4, BBS5, TTC8, ARL6, TMEM67
intracellular organelle part (GO:0044446)	-	0.81	0.004	CEP290, MKKS, MKS1, TRIM32, IFT27, BBS1, ARL6, TTC21B, BBS7, BBS9, BBS4, BBS5, KIF7, TTC8, CCDC28B, BBS2, SDCCAG8, TMEM67
axoneme part (GO:0044447)	-	6.67	0.044	ARL6, WDPCP
ciliary part (GO:0044441)	-	4.05	0.0	BBS9, CEP290, BBS4, MKS1, IFT27, BBS1, ARL6, BBS7, WDPCP, TMEM67, LZTFL1, BBS5, BBS2, TTC8
organelle part (GO:0044422)	-	0.79	0.001	BBS9, CEP290, BBS2, BBS4, MKS1, CCDC28B, IFT27, BBS1, ARL6, BBS7, TRIM32, SDCCAG8, MKKS, BBS5, WDPCP, TTC21B, TTC8, KIF7, TMEM67
BBSome (GO:0034464)	-	7.5	0.0	LZTFL1, BBS1, BBS7, BBS9, BBS4, BBS5, TTC8, BBIP1, BBS2