Disease table of RETINITIS PIGMENTOSA OMIM ID: PS268000

Gene-disease associations table

Gene	Associated with RETINITIS PIGMENTOSA in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
RGR	ClinVar, OMIM, HUMSAVAR	HGNC link	10q23.1	1	PS268000
MERTK	ClinVar, OMIM, HUMSAVAR	HGNC link	2q13	1	PS268000
USH2A	ClinVar, OMIM, HUMSAVAR	HGNC link	1q41	2	PS276900, PS268000
RPE65	ClinVar, OMIM, HUMSAVAR	HGNC link	1p31.3	2	PS204000, PS268000
CRX	ClinVar, HUMSAVAR	HGNC link	19q13.33	4	PS204000, PS268000, 120970, 153870
NR2E3	ClinVar, OMIM, HUMSAVAR	HGNC link	15q23	2	PS268000, 268100
TOPORS	OMIM	HGNC link	9p21.1	1	PS268000
DHDDS	ClinVar, OMIM, HUMSAVAR	HGNC link	1p36.11	1	PS268000
ARL6	ClinVar, OMIM, HUMSAVAR	HGNC link	3q11.2	2	PS209900, PS268000
PRPH2	ClinVar, OMIM, HUMSAVAR	HGNC link	6p21.1	6	PS204000, PS268000, PS169150, PS215500, 136880, PS153840
PRPF8	ClinVar, OMIM, HUMSAVAR	HGNC link	17p13.3	1	PS268000
HGSNAT	ClinVar, OMIM, HUMSAVAR	HGNC link	8p11.21	2	PS607014, PS268000
SEMA4A	ClinVar, OMIM, HUMSAVAR	HGNC link	1q22	2	610283, PS268000
PRPF3	ClinVar, OMIM, HUMSAVAR	HGNC link	1q21.2	1	PS268000
PRCD	ClinVar, OMIM, HUMSAVAR	HGNC link	17q25.1	1	PS268000
PRPF4	ClinVar, OMIM, HUMSAVAR	HGNC link	9q32	1	PS268000
PRPF6	ClinVar, OMIM, HUMSAVAR	HGNC link	20q13.33	1	PS268000
FAM161A	ClinVar, OMIM	HGNC link	2p15	1	PS268000
SNRNP200	ClinVar, OMIM, HUMSAVAR	HGNC link	2q11.2	1	PS268000
IFT140	ClinVar	HGNC link	16p13.3	2	PS208500, PS268000
PANK2	ClinVar	HGNC link	20p13	3	PS268000, 607236, PS234200
NEK2	OMIM	HGNC link	1q32.3	1	PS268000
IDH3B	ClinVar, OMIM, HUMSAVAR	HGNC link	20p13	1	PS268000
CNGB1	ClinVar, OMIM, HUMSAVAR	HGNC link	16q21	1	PS268000
PRPF31	ClinVar, OMIM, HUMSAVAR	HGNC link	19q13.42	1	PS268000
TULP1	ClinVar, OMIM, HUMSAVAR	HGNC link	6p21.31	2	PS204000, PS268000
SAG	OMIM	HGNC link	2q37.1	2	PS310500, PS268000
IMPDH1	ClinVar, OMIM, HUMSAVAR	HGNC link	7q32.1	2	PS204000, PS268000
FSCN2	OMIM	HGNC link	17q25.3	1	PS268000
C2orf71	ClinVar, OMIM, HUMSAVAR	HGNC link	2p23.2	1	PS268000
CERKL	ClinVar, OMIM, HUMSAVAR	HGNC link	2q31.3	1	PS268000
KLHL7	ClinVar, OMIM, HUMSAVAR	HGNC link	7p15.3	1	PS268000
RPGR	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp11.4	4	300455, 304020, PS268000, 300834
LRAT	ClinVar	HGNC link	4q32.1	2	PS204000, PS268000
OFD1	ClinVar, OMIM	HGNC link	Xp22.2	4	311200, PS213300, PS268000, 300209
RP1L1	ClinVar	HGNC link	8p23.1	2	613587, PS268000
CLRN1	ClinVar, OMIM, HUMSAVAR	HGNC link	3q25.1	2	PS276900, PS268000
RP1	ClinVar, OMIM, HUMSAVAR	HGNC link	8q11.23	1	PS268000
RP2	ClinVar, OMIM, HUMSAVAR	HGNC link	Xp11.3	1	PS268000
RHO	ClinVar, OMIM, HUMSAVAR	HGNC link	3q22.1	3	PS310500, 136880, PS268000
ROM1	ClinVar, OMIM	HGNC link	11q12.3	2	PS204000, PS268000
RP9	ClinVar, OMIM, HUMSAVAR	HGNC link	7p14.3	1	PS268000
CRB1	ClinVar, OMIM, HUMSAVAR	HGNC link	1q31.3	3	PS204000, PS268000, 172870
TTC8	ClinVar, OMIM	HGNC link	14q31.3	2	PS209900, PS268000
CNGA1	ClinVar, OMIM, HUMSAVAR	HGNC link	4p12	1	PS268000
EYS	ClinVar, OMIM, HUMSAVAR	HGNC link	6q12	1	PS268000
RBP3	ClinVar, OMIM, HUMSAVAR	HGNC link	10q11.22	1	PS268000
CYGB	ClinVar	HGNC link	17q25.1	1	PS268000
PROM1	ClinVar, OMIM	HGNC link	4p15.32	5	612657, PS268000, 603786, 608051, 120970
ZNF513	ClinVar, OMIM, HUMSAVAR	HGNC link	2p23.3	1	PS268000
MAK	ClinVar, OMIM, HUMSAVAR	HGNC link	6p24.2	1	PS268000
KIZ	ClinVar, OMIM	HGNC link	20p11.23	1	PS268000
IMPG2	ClinVar, OMIM	HGNC link	3q12.3	2	PS153840, PS268000
NRL	ClinVar, OMIM, HUMSAVAR	HGNC link	14q12	1	PS268000
SLC7A14	ClinVar, OMIM, HUMSAVAR	HGNC link	3q26.2	1	PS268000
IFT172	ClinVar, OMIM, HUMSAVAR	HGNC link	2p23.3	2	PS208500, PS268000
BBS2	ClinVar, OMIM, HUMSAVAR	HGNC link	16q13	2	PS209900, PS268000
CA4	ClinVar, OMIM, HUMSAVAR	HGNC link	17q23.1	1	PS268000
PDE6B	ClinVar, OMIM, HUMSAVAR	HGNC link	4p16.3	2	PS310500, PS268000
ABCA4	ClinVar, OMIM	HGNC link	1p22.1	4	248200, PS268000, 604116, PS603075
PDE6A	ClinVar, OMIM, HUMSAVAR	HGNC link	5q32	1	PS268000
PDE6G	ClinVar, OMIM	HGNC link	17q25.3	1	PS268000
RDH12	ClinVar, OMIM, HUMSAVAR	HGNC link	14q24.1	2	PS204000, PS268000
CDHR1	OMIM, HUMSAVAR	HGNC link	10q23.1	1	PS268000
ZNF408	ClinVar, OMIM, HUMSAVAR	HGNC link	11p11.2	2	PS133780, PS268000
BEST1	ClinVar, OMIM, HUMSAVAR	HGNC link	11q12.3	4	PS268000, PS153840, 611809, 193220
MYO7A	ClinVar	HGNC link	11q13.5	4	PS124900, PS220290, PS268000, PS276900
C8orf37	ClinVar, OMIM, HUMSAVAR	HGNC link	8q22.1	1	PS268000
GUCA1B	ClinVar, OMIM, HUMSAVAR	HGNC link	6p21.1	1	PS268000

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
2p23.3	2	ZNF513, IFT172
11q12.3	2	ROM1, BEST1
10q23.1	2	CDHR1, RGR
6p21.1	2	PRPH2, GUCA1B
20p13	2	PANK2, IDH3B
17q25.3	2	PDE6G, FSCN2
17q25.1	2	PRCD, CYGB

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
2p23	3	ZNF513, IFT172, C2orf71
20p13	2	PANK2, IDH3B
6p21	3	PRPH2, GUCA1B, TULP1
10q23	2	CDHR1, RGR
17q25	4	PRCD, PDE6G, CYGB, FSCN2
19q13	2	CRX, PRPF31
11q12	2	ROM1, BEST1
Xp11	2	RPGR, RP2

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
2p2	3	ZNF513, IFT172, C2orf71
19q1	2	CRX, PRPF31
1p3	2	RPE65, DHDDS
6p2	4	MAK, PRPH2, GUCA1B, TULP1
20p1	3	PANK2, IDH3B, KIZ
2q3	2	SAG, CERKL
2q1	2	SNRNP200, MERTK
3q2	3	SLC7A14, CLRN1, RHO
3q1	2	IMPG2, ARL6
7p1	2	RP9, KLHL7
1q3	2	NEK2, CRB1
1q2	2	PRPF3, SEMA4A
Xp1	2	RPGR, RP2
17q2	5	PRCD, CA4, CYGB, PDE6G, FSCN2
11q1	3	ROM1, MYO7A, BEST1
10q2	2	CDHR1, RGR
4p1	3	PROM1, PDE6B, CNGA1

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
20p	3	PANK2, IDH3B, KIZ
14q	3	RDH12, TTC8, NRL
7p	2	RP9, KLHL7
10q	3	RBP3, CDHR1, RGR
16q	2	CNGB1, BBS2
1q	5	NEK2, SEMA4A, PRPF3, USH2A, CRB1
1p	3	ABCA4, RPE65, DHDDS
3q	5	RHO, CLRN1, ARL6, SLC7A14, IMPG2
19q	2	CRX, PRPF31
6p	4	MAK, PRPH2, GUCA1B, TULP1
11q	3	ROM1, MYO7A, BEST1
8p	2	RP1L1, HGSNAT
8q	2	RP1, C8orf37
17q	5	PRCD, CA4, CYGB, PDE6G, FSCN2
2p	4	FAM161A, ZNF513, IFT172, C2orf71
2q	4	SNRNP200, SAG, CERKL, MERTK
4p	3	PROM1, PDE6B, CNGA1
Xp	3	RPGR, OFD1, RP2

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
11	4	ROM1, BEST1, ZNF408, MYO7A
10	3	RBP3, CDHR1, RGR
14	3	RDH12, TTC8, NRL
17	6	PRCD, CYGB, FSCN2, CA4, PDE6G, PRPF8
16	3	CNGB1, BBS2, IFT140
19	2	CRX, PRPF31
20	4	IDH3B, PRPF6, PANK2, KIZ
1	8	NEK2, ABCA4, PRPF3, RPE65, USH2A, CRB1, DHDDS, SEMA4A
3	5	RHO, CLRN1, ARL6, SLC7A14, IMPG2
2	8	SNRNP200, CERKL, MERTK, ZNF513, C2orf71, FAM161A, SAG, IFT172
4	4	LRAT, PROM1, PDE6B, CNGA1
7	3	IMPDH1, RP9, KLHL7
6	5	EYS, MAK, PRPH2, GUCA1B, TULP1
9	2	PRPF4, TOPORS
8	4	RP1, RP1L1, HGSNAT, C8orf37
X	3	RPGR, OFD1, RP2

Transcription Factors (TF) annotation from TRRUST

TF	associated to this disease	# regulated genes	Regulated genes	# regulated genes associated with this disease	Regulated genes associated with this disease
CRX	YES	5	RS1, RHO, NR2E3, RBP3, BEST1	4	RHO, NR2E3, RBP3, BEST1
NR2E3	YES	2	ESR1, RHO	1	RHO
NRL	YES	4	RHO, NR2E3, RBP3, PDE6B	4	RHO, NR2E3, RBP3, PDE6B
KLF15	NO	4	RHO, LRP5, RBP3, CLCNKA	2	RHO, RBP3
SP1	NO	460	ITGB3, KRT14, CDK4, UGCG, PGR, GAST, PSIP1, ITGA5, PTHLH, ITGB2, CD44, HLA-G, LTF, IGFBP4, NF1, ACVRL1, GSTP1, CYP2F1, CA9, MMRN1, HSD17B2, STK11, FGFR3, CD28, UGT1A4, FASLG, DNASE2, KRT19, SLC39A1, ALOX5, PDGFB, PTGS2, CYP7A1, TNF, TPMT, HSD11B2, FMR1, CHI3L1, PCK1, DMRT1, RARA, RASSF1, CYP3A7, BRD7, CYP17A1, LPL, CXADR, PADI3, ABCA1, NR5A1, COL11A2, IRF5, XIAP, BACE1, STAR, TBX21, BSG, APP, MDM2, COMP, ALOX12, CHRNB4, SNAP25, MTA1, CCK, DDB2, CIC, ACAN, KIT, MAT2A, SERPINB5, CDH2, ICAM1, SLC29A1, USP7, SLC5A8, HTR1A, REST, IGF2, APOC3, APAF1, ABCG2, IFNGR1, CRMP1, SLC7A5, PDGFC, HNF4A, ATP2C1, MICA, EAPP, TNFRSF10B, KRT5, MACROD1, ERVW-1, CD151, ELF4, MMP28, POLD2, DNMT1, MAOB, CBS, E2F1, KCNQ3, COL18A1, HIST2H4A, RPS3A, IL10, C4A, CYP3A5, ST6GAL1, CD99, BCL2, SLC15A1, IL6, ADAM10, KRT16, POLE2, MUC6, CBFB, ACO1, DCK, CAV1, MIF, DNMT3A, HMGA2, PDIA2, B4GALT1, GJA1, PPL, SLC13A4, AGTR1, PTGIR, CETP, SLC2A2, CYP27A1, F2R, BLMH, ADIPOQ, CENPH, OPRM1, BAG2, MPO, WRN, CDK6, PTTG1, YY1, CD2AP, TBXA2R, TGM4, PRSS50, HSD17B11, HCN2, MYCN, F3, ID4, CDKN1A, SLC5A1, SERPINE1, C1QBP, SOX3, EGR1, TF, RETN, SYP, RORA, NDUFV1, C4B, SNAPC1, TGFBR2, MME, GATA3, DPYSL2, CXCL14, SPRY2, ABCB8, COX4I1, SCTR, UGDH, HBEGF, PLAT, FOS, XPC, MUC5AC, HYAL1, BRCA1, NOS1, KCTD11, HCN4, ASPN, OXTR, COL1A1, TLR2, ALOX15B, ITGAV, IL5, SLC9A2, SIRT1, FGL2, KLF8, KCNQ2, UGT2B15, FOXM1, TEC, CHST4, TINF2, SLC19A3, KIF2C, ADAM23, PTGES, DNMT3B, GCLC, THBD, GFER, ADRBK1, TGFB1, SLC25A20, TK1, PRM1, CXCL1, APOE, PDE6A, TICAM1, KCNH2, TERF2, CENPW, NFKB1, ITGA2, PCYT1A, SIGIRR, IRS2, SP3, GIPR, SCNN1B, PTN, PTEN, NDUFV2, INSR, AGT, ME1, ATP2A2, HAS2, CYP19A1, HTT, MAT2B, PRNP, MNDA, SLC9A3, ADAM17, BAX, SLC3A2, UTRN, SPN, PAX6, SMARCA1, IL2, CREM, MMP9, ENG, CHGA, MUC4, ESR1, AHR, ATM, NFKB2, COL7A1, CD97, EPO, TFPI2, POR, DRG2, ELMO3, CAT, CYP3A4, LOXL4, BDKRB1, WAS, PNOC, LDHC, ADH6, CDC42BPG, NKX2-1, CYP1B1, TAF7, PLAUR, MMP2, MMP11, APLNR, UBC, GM2A, FGFR1, PLAA, TIMP1, TNFSF14, PTK6, KISS1, CDKN2B, COL2A1, BTK, ITGAX, HBZ, CREB1, MMP14, MICB, LEP, FOLR1, ATP2A3, SNRPN, ADA, PSEN1, SPP1, TNNI3, NOL7, VEGFA, CSNK2A1, VAMP2, NQO2, LOR, EPOR, HSD3B1, ISG20, MET, F10, CD1D, FBLN1, APLP1, CCL5, FAS, ERBB2, COPS5, MYBL1, RECQL4, CD83, SOD1, HOXB7, WIF1, SLC39A8, CES1, IL5RA, APEX1, ITGAD, TNC, KDR, CLDN3, NR4A1, MYC, RELA, RECK, PGLYRP2, LRP5, MYBL2, ADRA2B, VIM, EGFR, GDA, SOD2, FES, LDHA, CD14, AMACR, IGFBP1, SLC19A1, IMPDH2, PDE6B, LCAT, PPP2R2B, FBN1, CERS2, EPAS1, KLK3, FLNA, CCL2, HMGA1, BACE2, EDNRB, FABP6, HPR, IGFBP3, PON1, APOA1, NPY, B4GALT5, FXR2, CCND2, STARD3, IL2RB, DDB1, SQSTM1, TERT, HGF, TNFSF10, KRT18, TYMP, MUC2, MPG, ABCC3, HDAC4, TCN2, TYMS, DBF4, CASP3, SGPL1, GH2, EGF, CCND1, GPR39, IVL, AR, NT5E, LYZ, SMPD1, PHGDH, CDKN2A, MGST1, CCNA2, POLD1, NOS3, ABCB1, DHCR24, LDLR, HSD17B1, SOCS1, FBP1, LTC4S, CTSL, BIRC5, HRAS, PDHA1, TIMP2, P4HA1, TMPO, ARF6, CDKN1B, SLC31A1, SOX9, PLAU, RGN, CTSB, EZR, TIMP3, F7, SREBF1, SKP2, SCT, VDR, ADRB3, CXCL5, LMO4, CD163, MCTS1, ATF2, CTGF, SRC, P2RX4, TGFA, IL3, CYP7B1, ADRA1A, GRIN1, SRY, ODC1	2	PDE6A, PDE6B
OTX2	NO	12	TYR, POU1F1, HESX1, DCT, BEST1, AURKA, RBP3, IL6, CCNG2, IGF1, PAX6, CDC25C	2	RBP3, BEST1

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
CRX	YES	1	TFAP2A	0
NR2E3	YES	2	NRL, CRX	2	NRL, CRX
PANK2	YES	1	FOXN4	0
RHO	YES	5	NRL, CRX, NR2E3, KLF15, SOX2	3	NRL, CRX, NR2E3
RBP3	YES	5	KLF15, NRL, CRX, ZNF239, OTX2	2	NRL, CRX
PROM1	YES	3	SRY, DNMT1, HOXB4	0
PDE6B	YES	3	SP1, NRL, SP4	1	NRL
PDE6A	YES	1	SP1	0
BEST1	YES	5	CRX, OTX2, SOX9, MITF, OTX1	1	CRX

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
RGR	OFD1	No	1	KIAA1279
MERTK	PRPF8	No	1	HSP90AA1
MERTK	SNRNP200	No	1	HSP90AA1
USH2A	PRPF3	No	1	BRCA1
USH2A	FAM161A	No	1	BRCA1
USH2A	SNRNP200	No	1	BRCA1
RPE65	CRB1	No	1	PSMD13
CRX	PRPF6	No	1	PARK2
CRX	FAM161A	No	1	MDFI
CRX	SNRNP200	No	1	PARK2
CRX	NEK2	No	1	PARK2
CRX	PRPF31	No	1	AES
CRX	NRL	Yes	0
CRX	BBS2	No	1	MDFI
CRX	ZNF408	No	1	MDFI
TOPORS	PRPF8	No	10	HNRNPA1, HNRNPM, RANGAP1, UBC, S100A9, DHX15, PQBP1, UBE2I, SF3B1, TOP1
TOPORS	PRPF3	No	3	PQBP1, SF3B1, HNRNPM
TOPORS	PRPF4	No	5	PQBP1, HNRNPA1, SF3B1, DHX15, UBC
TOPORS	PRPF6	No	2	PQBP1, HNRNPM
TOPORS	SNRNP200	No	6	HNRNPA1, DHX15, PQBP1, UBE2I, SF3B1, TOP1
TOPORS	IDH3B	No	1	TP53
TOPORS	PRPF31	No	3	PQBP1, SF3B1, HNRNPA1
TOPORS	KLHL7	No	1	UBC
TOPORS	OFD1	No	2	TP53, PLK1
TOPORS	RHO	No	1	UBC
TOPORS	BBS2	No	1	EEF1A1
TOPORS	RDH12	No	1	UBE2D2
PRPF8	PRPF3	Yes	40	BCAS2, PRPF8, PABPC1, PCBP1, SF3B2, WWOX, SNRPD2, SRRM1, PQBP1, PLRG1, SF3B1, SRRM2, DDX23, EIF4A3, USP39, CDC5L, SLU7, RNPS1, SNRPA1, SEPT7, SNRNP40, SNRPD3, OBSL1, SNRNP70, PRPF3, SUPT16H, PRPF31, SART1, CD2BP2, SF3B3, PRPF6, MEPCE, PRPF19, SF3A1, PRPF4, SF3A2, SART3, HNRNPM, SEPT2, NTRK1
PRPF8	PRPF4	Yes	33	FN1, HNRNPA1, MEPCE, U2AF1, SNRNP200, PQBP1, PRPF8, SF3B1, SNW1, USP39, GPKOW, PRPF4B, SNRPA1, SNRNP40, OBSL1, PLRG1, PRPF3, SART1, UBC, PRPF31, DHX15, DDX23, SF3B3, PRPF6, PRPF19, SF3A1, PRPF4, SF3A2, SART3, HNRNPU, CUL3, NTRK1, EFTUD2
PRPF8	PRPF6	Yes	53	RNU12, BCAS2, PRPF8, LUC7L2, CDC5L, HNRNPM, RNU11, RPA1, PRPF4B, SNRPD2, SNRPD1, SIRT7, SNRNP200, PQBP1, SNW1, BSG, RPA3, DDX23, EIF4A3, MEX3C, TSSC4, RNPS1, SF3A2, WBP11, SNRPA1, SNRNP40, SNRPD3, U2AF1, OBSL1, RPA2, PRPF3, EED, SRRM2, SUPT16H, GIGYF2, SART1, CD2BP2, USP39, SF3B3, NOTCH1, PRPF6, MEPCE, GCFC2, SF3A1, PRPF19, PRPF4, PRPF31, CCDC8, REV, EFTUD2, NTRK1, MYC, CUL7
PRPF8	SNRNP200	Yes	90	AAR2, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, PQBP1, DDX23, PABPC1, RNPS1, SNRPE, SIRT7, FBXO6, ITGA4, SNRNP70, SNRPD3, EED, SNRPB, DHX15, SUZ12, FOXQ1, GCFC2, SF3A1, CCDC12, CUL3, PRPF8, PIN1, SF3B2, CCDC8, SF3B1, MAGOH, PRPF4B, RPA2, ERG, HDAC5, HSP90AA1, PRPF31, SART1, LUC7L2, RPA3, MED12, STAU1, MEPCE, SF3A2, REV, LGR4, HNRNPR, EBNA-LP, FN1, RPA1, CRNKL1, HNRNPA1, ZMYND11, PHF6, SIRT6, WWOX, TSSC4, RNF2, CD2BP2, CDK1, PRPF6, PRPF4, MCM5, HNRNPU, TOP1, NTRK1, CUL7, RNU12, BCAS2, FOXM1, RNU11, OBSL1, SRRM1, TAT, SRRM2, SNW1, USP39, VCAM1, SNRPA1, SNRNP40, CDKN1A, RBM5, MYC, SF3B3, PRPF19, HUWE1, USP9X, EFTUD2, RANBP2, UBE2I
PRPF8	IFT140	No	1	RANBP2
PRPF8	IDH3B	No	5	NTRK1, MYC, NXF1, CUL7, EBNA-LP
PRPF8	CNGB1	No	1	SRRM1
PRPF8	PRPF31	Yes	32	WWOX, PRPF8, MEPCE, PRPF4B, SNRPD2, HNRNPH2, SNRPD1, SNRNP200, PQBP1, HNRNPA1, SF3B1, USP39, RNPS1, WBP11, SNRPA1, SNRNP40, OBSL1, PRPF3, SART1, SF3A2, DDX23, CD2BP2, SF3B3, PRPF6, SF3A1, PRPF4, PRPF31, SART3, REV, EFTUD2, NTRK1, CUL3
PRPF8	IMPDH1	No	2	NTRK1, DDX3X
PRPF8	KLHL7	No	3	UBC, NXF1, CUL3
PRPF8	OFD1	No	5	NTRK1, LUC7L2, WDR83, CCDC8, PSMD14
PRPF8	RP2	No	1	CCDC8
PRPF8	RHO	No	1	UBC
PRPF8	RP9	No	2	NTRK1, U2AF1
PRPF8	MAK	No	1	SND1
PRPF3	PRPF4	Yes	35	PRPF8, SF3A3, USP15, SNRPA1, PQBP1, SF3B1, LSM1, HIST1H3E, KIFAP3, CEP250, NHP2L1, USP4, TFIP11, SNRNP40, PRPF4, OBSL1, PLRG1, WBP4, PRPF3, SART1, SF3A2, PATL1, DDX23, USP39, SF3B3, PRPF6, MEPCE, PRPF19, SF3A1, RPS10, PRPF31, SART3, CCDC84, NTRK1, PPIH
PRPF3	PRPF6	Yes	37	EIF4A3, PRPF8, CDC5L, SF3A3, SRSF5, SNRPD2, THRAP3, PQBP1, SON, TRA2A, DDX23, USP39, SRSF7, RNPS1, SRRM2, NHP2L1, SNRPA1, SF3B3, SNRNP40, PRPF4, SNRPD3, OBSL1, PRPF3, SUPT16H, PRPF31, SART1, CD2BP2, MMS19, PRPF6, MEPCE, PRPF19, SF3A1, U2AF2, SF3A2, HNRNPM, RAB4B, NTRK1
PRPF3	FAM161A	No	4	BRCA1, ZBTB8A, FAM9B, TFIP11
PRPF3	SNRNP200	No	39	BCAS2, PRPF8, PABPC1, SF3A3, TARDBP, SF3B2, WWOX, SNRPD2, SRRM1, PQBP1, SF3B1, SRRM2, EIF4A3, SMNDC1, USP39, CDC5L, RNPS1, SNRPA1, SNRNP40, PRPF4, BRCA1, OBSL1, SNRNP70, RBM39, SNRPD3, SART1, PRPF31, DDX23, CD2BP2, SF3B3, XAB2, PRPF6, MEPCE, PRPF19, SF3A1, U2AF2, SF3A2, RAB4B, NTRK1
PRPF3	NEK2	No	1	CEP250
PRPF3	IDH3B	No	2	NTRK1, MMS19
PRPF3	CNGB1	No	1	SRRM1
PRPF3	PRPF31	Yes	34	WWOX, PRPF8, SF3A3, SNRPD2, USP15, USP4, PQBP1, SF3B1, TFIP11, HIST1H3E, USP39, RNPS1, NHP2L1, RBM25, SNRPA1, SNRNP40, OBSL1, PRPF3, CTNNBL1, SART1, PRPF31, DDX23, CD2BP2, SF3B3, XAB2, PRPF6, MEPCE, SF3A1, PRPF4, SF3A2, SART3, FBL, NTRK1, PPIH
PRPF3	IMPDH1	No	2	NTRK1, NHP2L1
PRPF3	OFD1	No	4	NNT, NTRK1, AURKB, SNRPC
PRPF3	RP9	No	1	NTRK1
PRPF3	ZNF408	No	2	DVL3, ZBTB8A
PRPF4	PRPF6	Yes	26	PRPF8, SF3A3, U2AF1, SNRNP200, PQBP1, SNW1, USP39, NHP2L1, SNRPA1, SNRNP40, OBSL1, PRPF3, SART1, SF3A2, DDX23, PRPF31, SF3B3, PRPF6, MEPCE, PRPF19, SF3A1, PRPF4, TXNL4A, PRPF4B, NTRK1, EFTUD2
PRPF4	FAM161A	No	1	TFIP11
PRPF4	SNRNP200	Yes	35	FN1, PRPF8, RNU4ATAC, PRPF4, PRPF4B, SNRNP200, PQBP1, HNRNPA1, SF3B1, SNW1, LSM8, USP39, RNU6ATAC, SNRPA1, SRSF1, COPS5, SNRNP40, OBSL1, MEPCE, SART1, PRPF31, DHX15, DDX23, SF3B3, PRPF6, SNRPB2, PRPF19, SF3A1, SF3A3, SF3A2, CAND1, HNRNPU, CUL3, NTRK1, EFTUD2
PRPF4	IFT140	No	1	PFDN1
PRPF4	NEK2	No	2	CEP250, VCP
PRPF4	IDH3B	No	1	NTRK1
PRPF4	PRPF31	Yes	37	PRPF8, RNU4ATAC, VCP, PRPF4, XPO1, USP15, USP4, SNRNP200, PQBP1, HNRNPA1, SF3B1, TFIP11, HIST1H3E, USP39, NHP2L1, SNRPA1, RNU6ATAC, COPS5, SNRNP40, OBSL1, PRPF3, SART1, PRPF31, DDX23, SF3B3, PRPF6, MEPCE, SNRPB2, SF3A1, SF3A3, SF3A2, SART3, PRPF4B, CUL3, NTRK1, PPIH, EFTUD2
PRPF4	SAG	No	2	ARRB2, ARRB1
PRPF4	IMPDH1	No	3	NTRK1, NHP2L1, TXNDC5
PRPF4	KLHL7	No	2	UBC, CUL3
PRPF4	OFD1	No	3	NTRK1, CDC37, SASS6
PRPF4	RHO	No	3	UBC, ARRB2, ADRBK1
PRPF4	RP9	No	3	NTRK1, U2AF1, APP
PRPF4	MAK	No	1	APP
PRPF4	PDE6G	No	1	ADRBK1
PRPF4	ZNF408	No	1	LSM2
PRPF4	MYO7A	No	1	MGMT
PRPF6	SNRNP200	Yes	48	RNU12, BCAS2, PRPF8, LUC7L2, CDC5L, U2AF2, RNU11, RPA1, EIF4A3, SNRPD2, SNRPD1, SIRT7, SNRNP200, PQBP1, SNW1, SRRM2, RPA3, USP39, SNRPD3, RNPS1, REV, SNRPA1, SNRNP40, PRPF4, OBSL1, RPA2, TSSC4, EED, SART1, PRPF31, DDX23, CD2BP2, SF3B3, PRPF6, MEPCE, GCFC2, SF3A1, PRPF19, PARK2, SF3A2, CCDC8, PRPF4B, CUL7, RAB4B, NTRK1, SF3A3, MYC, EFTUD2
PRPF6	NEK2	No	2	PARK2, CTNNB1
PRPF6	IDH3B	No	4	NTRK1, MYC, MMS19, CUL7
PRPF6	PRPF31	Yes	29	PRPF8, PRPF4, PRPF4B, SNRPD2, SNRPD1, SNRNP200, PQBP1, USP39, RNPS1, NHP2L1, WBP11, SNRPA1, SNRNP40, TADA2A, OBSL1, PRPF3, SART1, SF3A2, DDX23, CD2BP2, SF3B3, PRPF6, MEPCE, SF3A1, SF3A3, PRPF31, REV, NTRK1, EFTUD2
PRPF6	IMPDH1	No	2	NTRK1, NHP2L1
PRPF6	OFD1	No	3	NTRK1, LUC7L2, CCDC8
PRPF6	RP2	No	1	CCDC8
PRPF6	RP9	No	2	NTRK1, U2AF1
PRPF6	MYO7A	No	1	CTNNB1
FAM161A	SNRNP200	No	1	BRCA1
FAM161A	NEK2	No	1	PDE4DIP
FAM161A	IDH3B	No	1	POC5
FAM161A	PRPF31	No	18	TSGA10, STX11, TMCC2, MTUS2, CCDC57, CTR9, KRTAP10-9, SSX2IP, PDE4DIP, KRTAP10-3, PHC2, PNMA2, CEP70, CCDC136, MIPOL1, CALCOCO2, TFIP11, MID2
FAM161A	OFD1	No	10	CEP63, POC5, CCDC57, NINL, SPICE1, LCA5, CEP44, KIAA0753, TNIP1, SSX2IP
FAM161A	KIZ	No	1	KIAA0753
FAM161A	IFT172	No	1	LCA5
FAM161A	BBS2	No	1	MDFI
FAM161A	ZNF408	No	6	CALCOCO2, MDFI, PDE4DIP, CEP70, CCDC136, ZBTB8A
SNRNP200	IFT140	No	1	RANBP2
SNRNP200	NEK2	No	2	PARK2, MCC
SNRNP200	IDH3B	No	4	NTRK1, MYC, CUL7, EBNA-LP
SNRNP200	CNGB1	No	1	SRRM1
SNRNP200	PRPF31	Yes	34	WWOX, PRPF8, RNU4ATAC, PRPF4, SNRPD2, SNRPD1, SNRNP200, PQBP1, HNRNPA1, SF3B1, USP39, RNPS1, PRPF4B, SNRPA1, RNU6ATAC, COPS5, SNRNP40, OBSL1, SART1, PRPF31, DDX23, CD2BP2, SF3B3, XAB2, PRPF6, MEPCE, SNRPB2, SF3A1, SF3A3, SF3A2, REV, CUL3, NTRK1, EFTUD2
SNRNP200	IMPDH1	No	1	NTRK1
SNRNP200	KLHL7	No	2	CUL3, FERMT3
SNRNP200	RPGR	No	1	TUBB
SNRNP200	OFD1	No	4	NTRK1, TUBA1B, LUC7L2, CCDC8
SNRNP200	RP2	No	1	CCDC8
SNRNP200	RP9	No	1	NTRK1
SNRNP200	PDE6G	No	1	GRB2
SNRNP200	C8orf37	No	1	MCM2
IFT140	NEK2	Yes	1	NEK2
PANK2	KIZ	No	1	TACC3
NEK2	PRPF31	No	2	PDE4DIP, VCP
NEK2	OFD1	No	2	NDC80, ODF2
NEK2	MAK	No	1	FZR1
NEK2	SLC7A14	No	1	PPP1CA
NEK2	PDE6B	No	1	PPP1CC
NEK2	ZNF408	No	1	PDE4DIP
NEK2	MYO7A	No	1	CTNNB1
IDH3B	PRPF31	No	1	NTRK1
IDH3B	IMPDH1	No	1	NTRK1
IDH3B	KLHL7	No	2	NXF1, MOV10
IDH3B	RPGR	No	1	RPGRIP1L
IDH3B	OFD1	Yes	8	POC5, RPGRIP1L, TP53, CNTRL, OFD1, CEP164, NTRK1, PCM1
IDH3B	RP9	No	3	NTRK1, OFD1, OTUB1
IDH3B	KIZ	No	1	PCM1
IDH3B	IFT172	No	1	PCM1
CNGB1	ABCA4	Yes	0
PRPF31	IMPDH1	No	3	NTRK1, NHP2L1, RPL35
PRPF31	KLHL7	No	2	CUL3, UFL1
PRPF31	OFD1	No	5	NTRK1, CCDC57, TP53BP2, RPAP2, SSX2IP
PRPF31	RP9	No	1	NTRK1
PRPF31	ZNF408	No	8	LDOC1, CHAF1A, UPF2, CALCOCO2, CEP70, PDE4DIP, CCDC136, KHDRBS3
PRPF31	MYO7A	No	1	PRKAR1A
SAG	RHO	Yes	3	SAG, ARRB2, RHO
IMPDH1	OFD1	No	3	NTRK1, CTPS1, IMPDH2
IMPDH1	RP9	No	1	NTRK1
IMPDH1	CYGB	No	1	SH3KBP1
IMPDH1	NRL	No	1	EDF1
KLHL7	RHO	No	1	UBC
RPGR	OFD1	No	10	NUDCD3, RPGRIP1, FKBP4, RPGRIP1L, DNAJA1, TUBA1A, UNC45A, DNM2, DNAJC7, NUDC
RPGR	PDE6G	No	1	DNM2
LRAT	RDH12	No	1	NME2P1
OFD1	RP2	No	2	CSNK1E, CCDC8
OFD1	RHO	No	1	HSPA4
OFD1	RP9	Yes	2	NTRK1, OFD1
OFD1	KIZ	No	4	KIAA0753, PCM1, CEP192, CEP128
OFD1	IFT172	No	3	IFT57, LCA5, PCM1
OFD1	CA4	No	1	PIH1D1
OFD1	PDE6G	No	1	DNM2
RP2	RDH12	No	1	DAK
RHO	PDE6G	No	1	ADRBK1
RP9	MAK	No	1	APP
RP9	BEST1	No	1	PPP2CA
TTC8	BBS2	No	1	LZTFL1
PROM1	CDHR1	Yes	0
KIZ	IFT172	No	1	PCM1
BBS2	RDH12	No	1	RBPMS
BBS2	ZNF408	No	1	MDFI

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
USH2A	PRPF6	No	1	TP53
PRPF3	PRPF31	No	1	KRAS
PRPF3	PROM1	No	1	KRAS
SNRNP200	NEK2	No	1	MYC
PRPF31	PROM1	No	1	KRAS

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
MERTK	TOPORS	No	-	1	UBC
MERTK	DHDDS	No	-	1	UBC
MERTK	PRPF8	No	-	1	UBC
MERTK	PRPF4	No	-	1	UBC
MERTK	PRPF6	No	-	1	UBC
MERTK	SNRNP200	No	-	1	UBC
MERTK	IFT140	No	-	1	UBC
MERTK	PANK2	No	-	1	UBC
MERTK	NEK2	No	-	1	UBC
MERTK	IMPDH1	No	-	1	UBC
MERTK	KLHL7	No	-	1	UBC
MERTK	OFD1	No	-	1	UBC
MERTK	RP2	No	-	1	UBC
MERTK	RHO	No	-	1	UBC
MERTK	TTC8	No	-	1	UBC
MERTK	IFT172	No	-	1	UBC
MERTK	BBS2	No	-	1	UBC
MERTK	RDH12	No	-	1	UBC
USH2A	NEK2	No	-	1	NINL
USH2A	OFD1	No	-	1	NINL
CRX	SAG	No	-	1	RHO
CRX	RHO	Yes	activation, binding	2	NRL, PDC
CRX	NRL	Yes	binding	2	RHO, FIZ1
TOPORS	DHDDS	No	-	1	UBC
TOPORS	ARL6	No	-	1	TUBG1
TOPORS	PRPF8	No	-	1	UBC
TOPORS	PRPF4	No	-	1	UBC
TOPORS	PRPF6	No	-	1	UBC
TOPORS	SNRNP200	No	-	2	UBC, SUMO2
TOPORS	IFT140	No	-	1	UBC
TOPORS	PANK2	No	-	1	UBC
TOPORS	NEK2	No	-	9	TUBGCP5, UBE2D1, PLK1, CENPJ, TUBGCP6, TUBGCP4, UBE2E1, UBC, TUBG1
TOPORS	IMPDH1	No	-	1	UBC
TOPORS	KLHL7	No	-	1	UBC
TOPORS	OFD1	No	-	7	TUBGCP5, PLK1, CENPJ, TUBGCP6, TUBG1, UBC, TUBGCP4
TOPORS	RP2	No	-	1	UBC
TOPORS	RHO	No	-	1	UBC
TOPORS	TTC8	No	-	1	UBC
TOPORS	PROM1	No	-	1	TP53
TOPORS	IFT172	No	-	1	UBC
TOPORS	BBS2	No	-	1	UBC
TOPORS	RDH12	No	-	1	UBC
DHDDS	PRPF8	No	-	1	UBC
DHDDS	PRPF4	No	-	1	UBC
DHDDS	PRPF6	No	-	1	UBC
DHDDS	SNRNP200	No	-	1	UBC
DHDDS	IFT140	No	-	1	UBC
DHDDS	PANK2	No	-	1	UBC
DHDDS	NEK2	No	-	1	UBC
DHDDS	IMPDH1	No	-	1	UBC
DHDDS	KLHL7	No	-	1	UBC
DHDDS	OFD1	No	-	1	UBC
DHDDS	RP2	No	-	1	UBC
DHDDS	RHO	No	-	1	UBC
DHDDS	TTC8	No	-	1	UBC
DHDDS	IFT172	No	-	1	UBC
DHDDS	BBS2	No	-	1	UBC
DHDDS	RDH12	No	-	1	UBC
ARL6	NEK2	No	-	6	PAFAH1B1, TUBG2, TUBA1A, CLASP1, TUBGCP2, TUBG1
ARL6	OFD1	No	-	6	PAFAH1B1, TUBG2, TUBA1A, CLASP1, TUBGCP2, TUBG1
ARL6	RP2	No	-	1	ARL3
PRPF8	PRPF4	Yes	binding	119	AAR2, CDC40, PPP1R42, HNRNPK, SNRPD2, SNRPD1, RBMX, SNRNP200, SNRPN, RNPS1, SNRPE, SRSF1, DHX9, SNRNP70, PAPOLA, SNRPB, POLR2L, PATL1, PRPF6, POLR2I, SRSF11, SF3A1, DHX38, CLP1, PCBP2, PHF5A, SF3A3, POLR2G, SRSF4, PCF11, HNRNPD, HNRNPA1, PCBP1, SF3B2, SRSF9, HNRNPUL1, PRPF39, SF3B1, MAGOH, PTBP1, LSM6, NCBP2, POLR2A, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, SART1, MFAP1, SF3A2, DDX23, EEF2, POLR2B, HNRNPA3, NUDT21, POLR2D, NCBP1, HNRNPM, UBC, ZMAT2, EFTUD2, HNRNPR, U2AF1, CSTF3, POLR2J, POLR2F, SNRPA, LSM3, SRSF6, HNRNPA2B1, POLR2C, LSM5, GTF2F1, SRSF5, SRSF7, C10ORF11, HNRNPF, CD2BP2, SUGP1, SNRPB2, FUS, HNRNPA0, U2AF2, HNRNPU, CSTF1, SNRPF, SRSF2, PRPF4B, NFX1, SRRM1, CSTF2, YBX1, NAA38, DNAJC8, POLR2H, LSM1, UPF3B, SNRPD3, SF3B5, SNRPA1, ASCC3, SNRNP40, HNRNPL, RBM5, ALYREF, LSM7, SF3B3, CCAR1, HNRNPC, LSM4, PRPF19, PABPN1, TXNL4A, SRSF3, HNRNPH1, CPSF7, POLR2E, NHP2L1
PRPF8	PRPF6	Yes	binding	124	AAR2, CDC40, PPP1R42, HNRNPK, SNRPD2, SNRPD1, RBMX, SNRNP200, SNRPN, RNPS1, SNRPE, SRSF1, DHX9, SNRNP70, PAPOLA, SNRPB, POLR2L, PATL1, POLR2I, WDR69, SRSF11, SF3A1, DHX38, CLP1, PCBP2, PHF5A, SF3A3, POLR2G, SRSF4, HFM1, HNRNPD, HNRNPA1, U2AF2, SF3B2, SRSF9, HNRNPUL1, PRPF39, POLR2H, MAGOH, PTBP1, LSM6, NCBP2, POLR2A, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, SART1, MFAP1, SF3A2, DDX23, EEF2, POLR2B, HNRNPA3, NUDT21, LSM10, POLR2D, NCBP1, HNRNPM, PCF11, UBC, ZMAT2, EFTUD2, HNRNPR, U2AF1, CSTF3, POLR2J, POLR2F, SNRPA, LSM3, TFIP11, SRSF6, HNRNPA2B1, POLR2C, LSM5, GTF2F1, SRSF5, SRSF7, C10ORF11, HNRNPF, CD2BP2, SUGP1, SNRPB2, FUS, HNRNPA0, PRPF4, HNRNPU, CSTF1, SNRPF, SRSF2, PRPF4B, NFX1, SRRM1, CSTF2, YBX1, NAA38, DNAJC8, SF3B1, LSM1, UPF3B, SNRPD3, NHP2L1, SNRPA1, ASCC3, SNRNP40, HNRNPL, PCBP1, RBM5, ALYREF, LSM7, SF3B3, CCAR1, HNRNPC, LSM4, PRPF19, PABPN1, RBM25, TXNL4A, SRSF3, HNRNPH1, CPSF7, POLR2E, SF3B5
PRPF8	SNRNP200	Yes	binding	118	AAR2, CDC40, CDC5L, HNRNPK, SNRPD2, SNRPD1, RBMX, SLU7, RNPS1, SNRPE, POLR2B, DHX9, SNRNP70, SNRPD3, SNRPB, POLR2L, DHX15, XAB2, PRPF6, DHX38, SRSF11, SF3A1, POLR2I, CLP1, POLR2A, PHF5A, SF3A3, POLR2G, SRSF4, PCF11, HNRNPD, HNRNPA1, U2AF2, SF3B2, SRSF9, HNRNPUL1, POLR2H, MAGOH, PTBP1, NCBP2, PCBP2, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, SART1, MFAP1, SF3A2, DDX23, EEF2, HNRNPA3, NUDT21, CWC22, POLR2D, NCBP1, HNRNPM, BUD31, UBC, EFTUD2, HNRNPR, U2AF1, CSTF3, POLR2J, CRNKL1, POLR2F, SNRPA, TFIP11, SRSF6, HNRNPA2B1, POLR2C, RBM22, GTF2F1, SRSF5, SRSF7, HNRNPF, CD2BP2, SUGP1, SNRPB2, FUS, HNRNPA0, PRPF4, HNRNPU, CSTF1, DHX8, SNRPF, SRSF2, NFX1, SRRM1, CSTF2, YBX1, NAA38, DNAJC8, SF3B1, UPF3B, PAPOLA, NHP2L1, SNRPA1, SRSF1, SNRNP40, SNW1, HNRNPL, PLRG1, PCBP1, RBM5, ALYREF, SF3B3, CCAR1, HNRNPC, LSM4, PRPF19, PABPN1, TXNL4A, SRSF3, HNRNPH1, CPSF7, POLR2E, SF3B5
PRPF8	IFT140	No	-	1	UBC
PRPF8	PANK2	No	-	1	UBC
PRPF8	NEK2	No	-	2	UBC, SRSF1
PRPF8	IMPDH1	No	-	1	UBC
PRPF8	KLHL7	No	-	1	UBC
PRPF8	OFD1	No	-	1	UBC
PRPF8	RP2	No	-	1	UBC
PRPF8	RHO	No	-	1	UBC
PRPF8	TTC8	No	-	1	UBC
PRPF8	IFT172	No	-	1	UBC
PRPF8	BBS2	No	-	1	UBC
PRPF8	RDH12	No	-	1	UBC
PRPF4	PRPF6	Yes	binding	121	AAR2, CDC40, PPP1R42, HNRNPK, SNRPD2, SNRPD1, RBMX, SNRNP200, SNRPN, RNPS1, SNRPE, SRSF1, DHX9, EIF2AK4, SNRNP70, PAPOLA, SNRPB, POLR2L, PATL1, POLR2I, SRSF11, SF3A1, DHX38, SART3, PCBP2, PHF5A, SF3A3, POLR2G, SRSF4, PCF11, HNRNPD, PRPF8, PCBP1, SF3B2, SRSF9, HNRNPUL1, PRPF39, CLP1, POLR2H, MAGOH, PTBP1, LSM6, NCBP2, POLR2A, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, SART1, MFAP1, SF3A2, DDX23, EEF2, POLR2B, HNRNPA3, NUDT21, POLR2D, NCBP1, HNRNPM, UBC, ZMAT2, EFTUD2, HNRNPR, U2AF1, CSTF3, POLR2J, HNRNPA1, POLR2F, SNRPA, LSM3, SRSF6, HNRNPA2B1, POLR2C, LSM5, GTF2F1, SRSF5, SRSF7, C10ORF11, HNRNPF, CD2BP2, SUGP1, SNRPB2, FUS, HNRNPA0, U2AF2, HNRNPU, CSTF1, SNRPF, SRSF2, PRPF4B, NFX1, SRRM1, CSTF2, YBX1, NAA38, DNAJC8, SF3B1, LSM1, UPF3B, SNRPD3, SF3B5, SNRPA1, ASCC3, SNRNP40, HNRNPL, RBM5, ALYREF, LSM7, SF3B3, CCAR1, HNRNPC, LSM4, PRPF19, PABPN1, TXNL4A, SRSF3, HNRNPH1, CPSF7, POLR2E, NHP2L1
PRPF4	SNRNP200	Yes	binding	106	AAR2, CDC40, HNRNPK, SNRPD2, SNRPD1, RBMX, RNPS1, SNRPE, POLR2B, DHX9, SNRNP70, PAPOLA, SNRPB, POLR2L, PRPF6, DHX38, SRSF11, SF3A1, POLR2I, CLP1, POLR2A, PHF5A, SF3A3, POLR2G, SRSF4, PCF11, HNRNPD, PRPF8, PCBP1, SF3B2, SRSF9, HNRNPUL1, SF3B1, MAGOH, PTBP1, NCBP2, PCBP2, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, SART1, MFAP1, SF3A2, DDX23, EEF2, HNRNPA3, NUDT21, POLR2D, NCBP1, HNRNPM, UBC, EFTUD2, HNRNPR, U2AF1, CSTF3, POLR2J, HNRNPA1, POLR2F, SNRPA, SRSF6, HNRNPA2B1, POLR2C, GTF2F1, SRSF5, SRSF7, TXNL4A, CD2BP2, SUGP1, SNRPB2, FUS, HNRNPA0, U2AF2, HNRNPU, CSTF1, SNRPF, SRSF2, NFX1, SRRM1, CSTF2, YBX1, NAA38, DNAJC8, POLR2H, UPF3B, SNRPD3, SF3B5, SNRPA1, SRSF1, SNRNP40, HNRNPL, RBM5, ALYREF, SF3B3, CCAR1, HNRNPC, LSM4, PRPF19, PABPN1, HNRNPF, SRSF3, HNRNPH1, CPSF7, POLR2E, NHP2L1
PRPF4	IFT140	No	-	1	UBC
PRPF4	PANK2	No	-	1	UBC
PRPF4	NEK2	No	-	2	UBC, SRSF1
PRPF4	IMPDH1	No	-	1	UBC
PRPF4	KLHL7	No	-	1	UBC
PRPF4	OFD1	No	-	1	UBC
PRPF4	RP2	No	-	1	UBC
PRPF4	RHO	No	-	1	UBC
PRPF4	TTC8	No	-	1	UBC
PRPF4	IFT172	No	-	1	UBC
PRPF4	BBS2	No	-	2	UBC, GRP
PRPF4	RDH12	No	-	1	UBC
PRPF6	SNRNP200	Yes	binding	107	AAR2, CDC40, HNRNPK, SNRPD2, SNRPD1, RBMX, RNPS1, SNRPE, POLR2B, DHX9, SNRNP70, PAPOLA, SNRPB, POLR2L, DHX38, SRSF11, SF3A1, POLR2I, CLP1, POLR2A, PHF5A, SF3A3, POLR2G, SRSF4, PCF11, HNRNPD, PRPF8, U2AF2, SF3B2, SRSF9, HNRNPUL1, SF3B1, MAGOH, PTBP1, NCBP2, PCBP2, POLR2K, CPSF2, CPSF3, GTF2F2, SNRPG, SART1, MFAP1, SF3A2, DDX23, EEF2, HNRNPA3, NUDT21, POLR2D, NCBP1, HNRNPM, UBC, EFTUD2, HNRNPR, U2AF1, CSTF3, POLR2J, HNRNPA1, POLR2F, SNRPA, TFIP11, SRSF6, HNRNPA2B1, POLR2C, GTF2F1, SRSF5, SRSF7, TXNL4A, CD2BP2, SUGP1, SNRPB2, FUS, HNRNPA0, PRPF4, HNRNPU, CSTF1, SNRPF, SRSF2, NFX1, SRRM1, CSTF2, YBX1, NAA38, DNAJC8, POLR2H, UPF3B, SNRPD3, SF3B5, SNRPA1, SRSF1, SNRNP40, HNRNPL, PCBP1, RBM5, ALYREF, SF3B3, CCAR1, HNRNPC, LSM4, PRPF19, PABPN1, HNRNPF, SRSF3, HNRNPH1, CPSF7, POLR2E, NHP2L1
PRPF6	IFT140	No	-	1	UBC
PRPF6	PANK2	No	-	1	UBC
PRPF6	NEK2	No	-	2	UBC, SRSF1
PRPF6	IMPDH1	No	-	1	UBC
PRPF6	KLHL7	No	-	1	UBC
PRPF6	OFD1	No	-	1	UBC
PRPF6	RP2	No	-	1	UBC
PRPF6	RHO	No	-	1	UBC
PRPF6	TTC8	No	-	1	UBC
PRPF6	PROM1	No	-	1	AR
PRPF6	MAK	No	-	1	AR
PRPF6	IFT172	No	-	1	UBC
PRPF6	BBS2	No	-	1	UBC
PRPF6	RDH12	No	-	1	UBC
SNRNP200	IFT140	No	-	1	UBC
SNRNP200	PANK2	No	-	1	UBC
SNRNP200	NEK2	No	-	2	UBC, SRSF1
SNRNP200	IMPDH1	No	-	1	UBC
SNRNP200	KLHL7	No	-	1	UBC
SNRNP200	OFD1	No	-	1	UBC
SNRNP200	RP2	No	-	1	UBC
SNRNP200	RHO	No	-	1	UBC
SNRNP200	TTC8	No	-	1	UBC
SNRNP200	IFT172	No	-	1	UBC
SNRNP200	BBS2	No	-	1	UBC
SNRNP200	RDH12	No	-	1	UBC
IFT140	PANK2	No	-	1	UBC
IFT140	NEK2	No	-	1	UBC
IFT140	IMPDH1	No	-	1	UBC
IFT140	KLHL7	No	-	1	UBC
IFT140	OFD1	No	-	1	UBC
IFT140	RP2	No	-	1	UBC
IFT140	RHO	No	-	1	UBC
IFT140	TTC8	No	-	1	UBC
IFT140	IFT172	No	-	2	UBC, WDR19
IFT140	BBS2	No	-	1	UBC
IFT140	RDH12	No	-	1	UBC
PANK2	NEK2	No	-	1	UBC
PANK2	IMPDH1	No	-	1	UBC
PANK2	KLHL7	No	-	1	UBC
PANK2	OFD1	No	-	1	UBC
PANK2	RP2	No	-	1	UBC
PANK2	RHO	No	-	1	UBC
PANK2	TTC8	No	-	1	UBC
PANK2	IFT172	No	-	1	UBC
PANK2	BBS2	No	-	1	UBC
PANK2	RDH12	No	-	1	UBC
NEK2	IMPDH1	No	-	1	UBC
NEK2	KLHL7	No	-	1	UBC
NEK2	OFD1	Yes	binding	65	CEP76, TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP152, CEP70, ALMS1, CSNK1D, CEP135, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, HAUS2, CEP250, DYNLL1, TUBA1A, CNTRL, DYNC1H1, MAPRE1, DYNC1I2, SDCCAG8, PCNT, YWHAG, TUBGCP2, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, AZI1, PRKAR2B, TUBB4B, CEP78, CENPJ, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, TUBGCP3, CEP290, DCTN2, AJUBA, AURKA, CLASP1, PLK1, TUBGCP4, CEP72, PCM1, TUBG2, UBC, TUBB4A, PLK4, NDE1, TUBG1
NEK2	RP2	No	-	1	UBC
NEK2	RHO	No	-	1	UBC
NEK2	TTC8	No	-	2	UBC, AZI1
NEK2	IFT172	No	-	1	UBC
NEK2	BBS2	No	-	2	UBC, AZI1
NEK2	RDH12	No	-	1	UBC
IDH3B	IMPDH1	No	-	1	ACLY
CNGB1	RHO	No	-	1	GNAT1
CNGB1	CNGA1	Yes	binding	4	PDE6G, PDE6A, GNAT1, PDE6B
CNGB1	PDE6B	Yes	activation, binding	4	CNGA1, PDE6G, PDE6A, GNAT1
CNGB1	ABCA4	Yes	binding	0
CNGB1	PDE6A	Yes	activation	4	CNGA1, PDE6G, GNAT1, PDE6B
CNGB1	PDE6G	Yes	activation	4	CNGA1, PDE6A, GNAT1, PDE6B
SAG	RHO	Yes	activation, binding	1	GRK1
SAG	NRL	No	-	1	RHO
IMPDH1	KLHL7	No	-	1	UBC
IMPDH1	OFD1	No	-	1	UBC
IMPDH1	RP2	No	-	1	UBC
IMPDH1	RHO	No	-	1	UBC
IMPDH1	TTC8	No	-	1	UBC
IMPDH1	IFT172	No	-	1	UBC
IMPDH1	BBS2	No	-	1	UBC
IMPDH1	RDH12	No	-	1	UBC
KLHL7	OFD1	No	-	1	UBC
KLHL7	RP2	No	-	1	UBC
KLHL7	RHO	No	-	1	UBC
KLHL7	TTC8	No	-	1	UBC
KLHL7	IFT172	No	-	1	UBC
KLHL7	BBS2	No	-	1	UBC
KLHL7	RDH12	No	-	1	UBC
OFD1	RP2	No	-	1	UBC
OFD1	RHO	No	-	1	UBC
OFD1	TTC8	No	-	2	UBC, AZI1
OFD1	IFT172	No	-	1	UBC
OFD1	BBS2	No	-	2	UBC, AZI1
OFD1	RDH12	No	-	1	UBC
RP2	RHO	No	-	1	UBC
RP2	TTC8	No	-	1	UBC
RP2	IFT172	No	-	1	UBC
RP2	BBS2	No	-	1	UBC
RP2	RDH12	No	-	1	UBC
RHO	TTC8	No	-	1	UBC
RHO	CNGA1	No	-	1	GNAT1
RHO	NRL	Yes	activation, binding	1	CRX
RHO	IFT172	No	-	1	UBC
RHO	BBS2	No	-	1	UBC
RHO	PDE6B	No	-	4	GNAT3, GNAT2, GNGT1, GNAT1
RHO	PDE6A	No	-	4	GNAT3, GNAT2, GNGT1, GNAT1
RHO	PDE6G	No	-	4	GNAT3, GNAT2, GNGT1, GNAT1
RHO	RDH12	No	-	1	UBC
TTC8	IFT172	No	-	1	UBC
TTC8	BBS2	Yes	binding	10	LZTFL1, CCDC28B, BBS1, BBS7, BBS9, BBS4, BBS5, UBC, BBIP1, AZI1
TTC8	RDH12	No	-	1	UBC
CNGA1	PDE6B	Yes	activation, binding	4	PDE6G, CNGB1, PDE6A, GNAT1
CNGA1	ABCA4	No	-	1	CNGB1
CNGA1	PDE6A	Yes	activation	4	CNGB1, PDE6G, GNAT1, PDE6B
CNGA1	PDE6G	Yes	activation	4	CNGB1, PDE6A, GNAT1, PDE6B
PROM1	MAK	No	-	1	AR
PROM1	CDHR1	Yes	binding	0
IFT172	BBS2	No	-	1	UBC
IFT172	RDH12	No	-	1	UBC
BBS2	RDH12	No	-	1	UBC
PDE6B	ABCA4	No	-	1	CNGB1
PDE6B	PDE6A	Yes	binding	11	CNGA1, CNGB1, RGS9, GNB5, GNGT1, GNAT3, PDE6G, RGS9BP, GNAT2, PDE6H, GNAT1
PDE6B	PDE6G	Yes	binding	11	CNGA1, CNGB1, RGS9, GNB5, GNGT1, PDE6A, GNAT3, RGS9BP, GNAT2, PDE6H, GNAT1
ABCA4	PDE6A	No	-	1	CNGB1
ABCA4	PDE6G	No	-	1	CNGB1
PDE6A	PDE6G	Yes	binding	11	CNGA1, CNGB1, GNB5, PDE6B, GNGT1, RGS9, GNAT3, RGS9BP, GNAT2, PDE6H, GNAT1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Gene1	Gene2	Direct Interaction	Complexes	Number of shared interactors	Shared genes in interaction
PRPF8	PRPF3	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, SF3A3, THOC5, SRSF4, CWC15, RBM8A, WTAP, PRPF4, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, SF3A2, ALYREF, BUD13, SNU13, THOC3, CWC22, TCERG1, NCBP1, DHX8, BUD31, PRPF31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, THOC7, U2AF2, SKIV2L2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, ISY1, KIAA1429, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF8	PRPF4	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, CWC15, RBM8A, WTAP, U2AF2, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, KIAA1429, SF3A2, ALYREF, BUD13, SNU13, THOC3, CWC22, TCERG1, NCBP1, DHX8, BUD31, PRPF31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, THOC7, SF3A3, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, PRPF3, SKIV2L2, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF8	PRPF6	Yes	Spliceosome;C complex spliceosome	161	SF1, DDX5, CDC40, CDC5L, HNRNPK, EIF4A3, SNRPD2, SNRPD1, RBMX, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, SYNCRIP, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, SF3A3, THOC5, SRSF4, CWC15, RBM8A, WTAP, RALY, ACIN1, SF3B2, SRSF9, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, ZCCHC8, SNRPG, CDK12, SART1, KIAA1429, HNRNPA3, TCERG1, ALYREF, BUD13, DHX35, THOC3, CWC22, SF3A2, NCBP1, HNRNPM, DHX8, BUD31, PRPF31, SRRT, HNRNPR, WDR83, PABPC1, U2AF1, HNRNPU, DHX16, GPATCH1, DHX38, CRNKL1, HNRNPA1, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, HNRNPA2B1, PRPF4, RBM22, PPIE, THOC6, SNU13, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, HNRNPF, CD2BP2, MOV10, SNRPB2, THOC7, U2AF2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, CWC27, BCAS2, SNRPF, PNN, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, FRG1, C19ORF43, MFAP1, PLRG1, PRPF3, SKIV2L2, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, HNRNPC, LSM4, PRPF19, DDX17, RBM25, TXNL4A, SRSF3, HNRNPH1, EFTUD2, RBM17, PRPF18
PRPF8	SNRNP200	Yes	Spliceosome;C complex spliceosome;SNW1 complex	172	SF1, HNRNPC, DDX5, CDC40, CDC5L, HNRNPK, EIF4A3, SNRPD2, SNRPD1, RBMX, WTAP, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, MSH2, SNRPE, ZNF207, SYNCRIP, DHX9, AQR, EEF1A1, U2AF1, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, DDX3X, RBM8A, RALY, SF3A3, SF3B2, SRSF9, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, HNRNPU, DDB1, LSM6, PPWD1, TCERG1, SNRPC, PPIL3, PPIH, PFKL, SNRPG, CDK12, SMNDC1, SART1, KIAA1429, HNRNPA3, SF3A2, ALYREF, BUD13, DHX35, THOC3, CWC22, PRPF31, TUBB, NCBP1, HNRNPM, FNBP3, BUD31, ABCF2, SRRT, HNRNPR, WDR83, PABPC1, MATR3, DHX16, GPATCH1, DHX38, CRNKL1, HNRNPA1, HSPA5, CPSF6, LSM3, TFIP11, THOC2, SFPQ, SRSF6, LUC7L3, PPM1G, HNRNPA2B1, PRPF4, RBM22, EEF1G, PPIE, THOC6, SNU13, SRSF5, SRSF7, DDX41, NUDT21, PRPF40A, HNRNPF, CD2BP2, MOV10, UBR5, PRPF6, SNRPB2, CWC15, U2AF2, PRPF4B, DDX46, RBM39, PUF60, DHX8, CWC27, BCAS2, SNRPF, PNN, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, DDX39B, IK, SNRPA1, SRSF1, SNRNP40, FRG1, ACIN1, C19ORF43, MFAP1, PLRG1, PRPF3, SKIV2L2, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, ZCCHC8, LSM4, PRPF19, DDX17, RBM25, TXNL4A, SRSF3, HNRNPH1, EFTUD2, RBM17, THOC7, PRPF18
PRPF8	PRPF31	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, LUC7L3, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, DDX3X, RBM8A, WTAP, SF3A3, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, WBP11, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, TCERG1, SPEN, BUD13, SNU13, THOC3, CWC22, SF3A2, NCBP1, DHX8, BUD31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, DHX9, PPM1G, PRPF4, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, CWC15, U2AF2, SKIV2L2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, KIAA1429, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, PRPF3, THOC1, ALYREF, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, THOC7, PRPF18
PRPF3	PRPF4	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, CWC15, PRPF8, WTAP, U2AF2, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, SF3A2, ALYREF, BUD13, SNU13, THOC3, CWC22, TCERG1, NCBP1, DHX8, BUD31, PRPF31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, THOC7, SF3A3, SKIV2L2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, ISY1, KIAA1429, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF3	PRPF6	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, SF3A3, THOC5, SRSF4, CWC15, PRPF8, WTAP, PRPF4, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, SF3A2, ALYREF, BUD13, SNU13, THOC3, CWC22, TCERG1, NCBP1, DHX8, BUD31, PRPF31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, SNRPB2, THOC7, U2AF2, SKIV2L2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, ISY1, KIAA1429, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF3	SNRNP200	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, WTAP, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, SF3A3, THOC5, SRSF4, CWC15, PRPF8, PRPF4, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, SF3A2, ALYREF, BUD13, SNU13, THOC3, CWC22, TCERG1, NCBP1, DHX8, BUD31, PRPF31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, THOC7, U2AF2, SKIV2L2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, ISY1, KIAA1429, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF3	PRPF31	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, SF3A3, THOC5, SRSF4, CWC15, PRPF8, WTAP, PRPF4, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, TCERG1, ALYREF, BUD13, SNU13, THOC3, CWC22, SF3A2, NCBP1, DHX8, BUD31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, THOC7, U2AF2, SKIV2L2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, ISY1, KIAA1429, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF4	PRPF6	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, CWC15, PRPF8, WTAP, U2AF2, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, KIAA1429, SF3A2, ALYREF, BUD13, SNU13, THOC3, CWC22, TCERG1, NCBP1, DHX8, BUD31, PRPF31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, SNRPB2, THOC7, SF3A3, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, PRPF3, SKIV2L2, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF4	SNRNP200	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, WTAP, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, CWC15, PRPF8, U2AF2, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, KIAA1429, SF3A2, ALYREF, BUD13, SNU13, THOC3, CWC22, TCERG1, NCBP1, DHX8, BUD31, PRPF31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, THOC7, SF3A3, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, PRPF3, SKIV2L2, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF4	PRPF31	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, CWC15, PRPF8, WTAP, U2AF2, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, KIAA1429, TCERG1, ALYREF, BUD13, SNU13, THOC3, CWC22, SF3A2, NCBP1, DHX8, BUD31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, THOC7, SF3A3, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, PRPF3, SKIV2L2, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
PRPF6	SNRNP200	Yes	Spliceosome;C complex spliceosome	161	SF1, DDX5, CDC40, CDC5L, HNRNPK, EIF4A3, SNRPD2, SNRPD1, RBMX, WTAP, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, SYNCRIP, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, SF3A3, THOC5, SRSF4, CWC15, PRPF8, RALY, ACIN1, SF3B2, SRSF9, HTATSF1, SF3B1, PPIL2, HNRNPA1, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, ZCCHC8, SNRPG, CDK12, SART1, KIAA1429, HNRNPA3, TCERG1, ALYREF, BUD13, DHX35, THOC3, CWC22, SF3A2, NCBP1, HNRNPM, DHX8, BUD31, PRPF31, SRRT, HNRNPR, WDR83, PABPC1, U2AF1, HNRNPU, DHX16, GPATCH1, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, HNRNPA2B1, PRPF4, RBM22, PPIE, THOC6, SNU13, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, HNRNPF, CD2BP2, MOV10, SNRPB2, THOC7, U2AF2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, CWC27, BCAS2, SNRPF, PNN, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, FRG1, C19ORF43, MFAP1, PLRG1, PRPF3, SKIV2L2, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, HNRNPC, LSM4, PRPF19, DDX17, RBM25, TXNL4A, SRSF3, HNRNPH1, EFTUD2, RBM17, PRPF18
PRPF6	PRPF31	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, SNRNP200, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, DHX9, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, WBP11, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, CWC15, PRPF8, WTAP, SF3A3, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, DDX3X, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, TCERG1, ALYREF, BUD13, SNU13, THOC3, CWC22, SF3A2, NCBP1, DHX8, BUD31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, LUC7L3, PPM1G, PRPF4, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, SNRPB2, THOC7, U2AF2, SKIV2L2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, THOC1, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, PRPF3, KIAA1429, SPEN, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, PRPF18
SNRNP200	PRPF31	Yes	Spliceosome	141	SF1, DDX5, CDC40, CDC5L, EIF4A3, SNRPD2, SNRPD1, WTAP, LSM2, SF3B6, SYF2, DDX23, PAXBP1, SLU7, RNPS1, SNRPE, ZNF207, LUC7L3, AQR, SNRNP27, CACTIN, SNRNP70, SNRPD3, CTNNBL1, CFAP20, SNRPB, DHX15, XAB2, SRSF11, SF3A1, RBM15, IGF2BP3, CIRBP, THOC5, SRSF4, DDX3X, PRPF8, SF3A3, SF3B2, MFAP1, HTATSF1, SF3B1, PPIL2, MAGOH, ISY1, TRA2B, SNRPA, NCBP2, WBP11, LSM6, PPWD1, SNRPC, PPIL3, PPIH, SNRPG, CDK12, SART1, TCERG1, SPEN, BUD13, SNU13, THOC3, CWC22, SF3A2, NCBP1, DHX8, BUD31, SRRT, PABPC1, U2AF1, DHX16, DHX38, CRNKL1, RBM8A, CPSF6, LSM3, TFIP11, THOC2, SMNDC1, SRSF6, DHX9, PPM1G, PRPF4, RBM22, PPIE, THOC6, SRSF5, DDX39B, DDX41, NUDT21, PRPF40A, TXNL4A, CD2BP2, MOV10, PRPF6, SNRPB2, CWC15, U2AF2, SKIV2L2, PRPF4B, DDX46, RBM39, PUF60, FNBP3, BCAS2, SNRPF, SRSF2, SRRM1, SMU1, DNAJC8, SRRM2, SNW1, U2SURP, KIAA1429, USP39, SRSF7, IK, SNRPA1, SRSF1, SNRNP40, ACIN1, C19ORF43, SRSF9, PLRG1, PRPF3, THOC1, ALYREF, SF3B4, LSM7, PPIL1, DGCR14, SF3B3, LSM4, PRPF19, DDX17, RBM25, SRSF3, EFTUD2, RBM17, THOC7, PRPF18

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CENSUS

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
PRPF8	PRPF3	Yes	12	PRPF6, CDC5L, PRPF19, SNRPA1, SF3A1, HNRNPM, SUPT16H, SART1, SF3A2, SEPT2, SNRPD2, SEPT7
PRPF8	PRPF4	No	4	HNRNPU, PRPF3, PRPF19, SNRPA1
PRPF8	PRPF6	Yes	13	CD2BP2, SNRPD3, SNRPA1, PRPF19, U2AF1, HNRNPM, SNRPD2, SART1, SNRPD1, SUPT16H, SNRNP200, PRPF3, SF3B3
PRPF8	SNRNP200	Yes	18	EFTUD2, AAR2, SNRNP70, SNRPD3, PRPF19, SNRNP40, SF3A1, HUWE1, HNRNPU, SNRPD2, SNRPD1, SNRPA1, CD2BP2, PRPF6, CDC5L, SF3B1, SF3B3, CRNKL1
PRPF8	PRPF31	No	7	PRPF6, SF3A1, SNRPA1, SF3A2, SART1, SF3B1, SF3B3
PRPF8	IMPDH1	No	1	DDX3X
PRPF3	PRPF4	Yes	5	RPS10, PATL1, LSM1, PRPF19, SNRPA1
PRPF3	PRPF6	Yes	14	EIF4A3, SRSF5, SON, PRPF19, SRSF7, SNRPA1, U2AF2, HNRNPM, SNRPD2, SART1, THRAP3, SUPT16H, PRPF8, SRRM2
PRPF3	SNRNP200	No	10	BCAS2, PRPF8, PABPC1, PRPF19, SF3A1, U2AF2, SNRPD2, SNRPA1, PRPF6, CDC5L
PRPF3	PRPF31	No	6	PRPF6, SF3A1, SF3A3, SART1, SF3A2, SNRPA1
PRPF4	PRPF6	No	3	PRPF3, PRPF19, SNRPA1
PRPF4	SNRNP200	No	4	HNRNPU, SNRPB2, PRPF19, SNRPA1
PRPF4	PRPF31	No	2	SNRPA1, SNRPB2
PRPF6	SNRNP200	Yes	9	PRPF8, SNRPD3, PRPF19, U2AF2, SNRPD2, SNRPD1, SNRPA1, CD2BP2, SF3B3
PRPF6	PRPF31	Yes	3	SF3B3, SNRPA1, SART1
SNRNP200	PRPF31	No	6	PRPF6, SNRPB2, SF3A1, SNRPA1, SF3B1, SF3B3

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
PRPF8	PRPF3	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF8	PRPF4	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF8	PRPF6	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF8	SNRNP200	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF8	PRPF31	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF3	PRPF4	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF3	PRPF6	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF3	SNRNP200	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF3	PRPF31	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF4	PRPF6	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF4	SNRNP200	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF4	PRPF31	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF6	SNRNP200	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
PRPF6	PRPF31	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2
SNRNP200	PRPF31	Yes	10	PRPF8, PRPF3, SNRPE, PRPF4, TXNL4A, SNRPB, PRPF31, SNRNP200, PRPF6, EFTUD2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Phototransduction	hsa04744	7.91	7	CNGA1, CNGB1, PDE6B, PDE6A, PDE6G, RHO, GUCA1B
Spliceosome	hsa03040	5.73	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
Metabolic pathways	hsa01100	2.49	5	IDH3B, HGSNAT, PANK2, RDH12, IMPDH1
Purine metabolism	hsa00230	5.28	4	PDE6G, PDE6A, IMPDH1, PDE6B
Retinol metabolism	hsa00830	6.79	3	RPE65, LRAT, RDH12
cGMP-PKG signaling pathway	hsa04022	5.32	2	CNGA1, CNGB1
cAMP signaling pathway	hsa04024	5.05	2	CNGA1, CNGB1
Olfactory transduction	hsa04740	4.13	2	CNGB1, GUCA1B

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Phototransduction (hsa04744)	-	7.91	0.0	CNGA1, CNGB1, PDE6B, PDE6A, PDE6G, RHO, GUCA1B
Transcription	NEW	5.07	0.004	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
Spliceosome (hsa03040)	-	5.73	0.004	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signal Transduction	R-HSA-162582	1.78	18	CNGA1, IFT172, PDE6B, RDH12, RBP3, SAG, PDE6A, CNGB1, RPE65, OFD1, PDE6G, RGR, GUCA1B, RHO, MYO7A, LRAT, IFT140, ABCA4
Visual phototransduction	R-HSA-2187338	6.44	14	CNGA1, CNGB1, RBP3, PDE6B, SAG, PDE6A, RDH12, RPE65, RHO, GUCA1B, PDE6G, MYO7A, LRAT, ABCA4
Organelle biogenesis and maintenance	R-HSA-1852241	4.63	10	IFT172, RP2, IFT140, CNGB1, NEK2, ARL6, OFD1, RHO, BBS2, TTC8
Assembly of the primary cilium	R-HSA-5617833	5.44	10	IFT172, RP2, IFT140, CNGB1, NEK2, ARL6, OFD1, RHO, BBS2, TTC8
The phototransduction cascade	R-HSA-2514856	8.03	8	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B
Inactivation, recovery and regulation of the phototransduction cascade	R-HSA-2514859	8.08	8	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B
The canonical retinoid cycle in rods (twilight vision)	R-HSA-2453902	8.52	7	RBP3, RDH12, ABCA4, RPE65, RHO, MYO7A, LRAT
Activation of the phototransduction cascade	R-HSA-2485179	9.52	7	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO
Cargo trafficking to the periciliary membrane	R-HSA-5620920	7.31	6	CNGB1, RP2, ARL6, RHO, TTC8, BBS2
Metabolism	R-HSA-1430728	2.34	6	CYGB, PANK2, CA4, HGSNAT, IDH3B, IMPDH1
Gene Expression	R-HSA-74160	2.72	5	NR2E3, PRPF8, PRPF4, PRPF6, SNRNP200
Disease	R-HSA-1643685	3.33	5	ABCA4, HGSNAT, DHDDS, LRAT, RDH12
mRNA Splicing - Major Pathway	R-HSA-72163	6.15	4	PRPF4, PRPF8, PRPF6, SNRNP200
Processing of Capped Intron-Containing Pre-mRNA	R-HSA-72203	6.1	4	PRPF4, PRPF6, PRPF8, SNRNP200
mRNA Splicing	R-HSA-72172	6.15	4	PRPF4, PRPF6, PRPF8, SNRNP200
mRNA Splicing - Minor Pathway	R-HSA-72165	7.59	3	PRPF6, PRPF8, SNRNP200
Signaling by Wnt	R-HSA-195721	4.79	3	PDE6G, PDE6A, PDE6B
Hedgehog 'off' state	R-HSA-5610787	6.19	3	IFT172, IFT140, OFD1
Diseases of signal transduction	R-HSA-5663202	4.89	3	ABCA4, RDH12, LRAT
beta-catenin independent WNT signaling	R-HSA-3858494	5.83	3	PDE6G, PDE6A, PDE6B
Diseases associated with visual transduction	R-HSA-2474795	9.28	3	ABCA4, RDH12, LRAT
Ca2+ pathway	R-HSA-4086398	7.1	3	PDE6G, PDE6A, PDE6B
Signaling by Hedgehog	R-HSA-5358351	5.79	3	IFT172, IFT140, OFD1
BBSome-mediated cargo-targeting to cilium	R-HSA-5620922	8.46	3	BBS2, TTC8, ARL6
Retinoid cycle disease events	R-HSA-2453864	9.28	3	ABCA4, RDH12, LRAT
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	6.68	2	OFD1, NEK2
Signaling by GPCR	R-HSA-372790	2.68	2	RHO, RGR
GPCR downstream signaling	R-HSA-388396	3.07	2	RHO, RGR
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.66	2	OFD1, NEK2
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.03	2	OFD1, NEK2
Centrosome maturation	R-HSA-380287	6.68	2	OFD1, NEK2
Opsins	R-HSA-419771	9.81	2	RHO, RGR
Mitotic G2-G2/M phases	R-HSA-453274	6.04	2	OFD1, NEK2
Transmembrane transport of small molecules	R-HSA-382551	3.79	2	ABCA4, BEST1
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.51	2	OFD1, NEK2
Cell Cycle, Mitotic	R-HSA-69278	4.16	2	OFD1, NEK2
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69	2	RHO, RGR
G alpha (i) signalling events	R-HSA-418594	5.1	2	RHO, RGR
VxPx cargo-targeting to cilium	R-HSA-5620916	8.59	2	CNGB1, RHO
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.03	2	OFD1, NEK2
Cell Cycle	R-HSA-1640170	3.89	2	OFD1, NEK2
GPCR ligand binding	R-HSA-500792	4.19	2	RHO, RGR
Intraflagellar transport	R-HSA-5620924	7.25	2	IFT172, IFT140
G2/M Transition	R-HSA-69275	6.06	2	OFD1, NEK2

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Diseases associated with visual transduction (R-HSA-2474795)	-	9.28	0.004	CNGB1, ABCA4, LRAT, RDH12
Visual phototransduction (R-HSA-2187338)	-	6.44	0.0	CNGA1, CNGB1, RDH12, PDE6B, SAG, PDE6A, RHO, RPE65, RBP3, GUCA1B, PDE6G, MYO7A, LRAT, ABCA4
Organelle biogenesis and maintenance (R-HSA-1852241)	-	4.63	0.0	IFT172, RHO, PDE6B, RP2, IFT140, CNGB1, NEK2, ARL6, OFD1, PRPF31, ZNF513, ABCA4, BBS2, TTC8, RPGR
Retinoid cycle disease events (R-HSA-2453864)	-	9.28	0.004	CNGB1, ABCA4, LRAT, RDH12
Activation of the phototransduction cascade (R-HSA-2485179)	-	9.52	0.0	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO
The phototransduction cascade (R-HSA-2514856)	-	8.03	0.0	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B
The canonical retinoid cycle in rods (twilight vision) (R-HSA-2453902)	-	8.52	0.0	RBP3, RDH12, ABCA4, RPE65, LRAT, RHO, MYO7A
Cargo trafficking to the periciliary membrane (R-HSA-5620920)	-	7.31	0.002	CNGB1, RP2, ARL6, RHO, TTC8, BBS2
Assembly of the primary cilium (R-HSA-5617833)	-	5.44	0.0	CNGB1, PDE6B, RP2, IFT140, IFT172, NEK2, ARL6, OFD1, RHO, BBS2, TTC8, RPGR
BBSome-mediated cargo-targeting to cilium (R-HSA-5620922)	-	8.46	0.016	BBS2, TTC8, ARL6
Inactivation, recovery and regulation of the phototransduction cascade (R-HSA-2514859)	-	8.08	0.0	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	56	IMPG2, CRX, PRPF8, RGR, RDH12, NR2E3, SAG, CYGB, ZNF408, CDHR1, SNRNP200, KLHL7, BBS2, ABCA4, FSCN2, FAM161A, PRPF3, RP9, PANK2, RBP3, CRB1, NRL, OFD1, RPE65, ZNF513, PDE6G, ARL6, TOPORS, USH2A, KIZ, CNGB1, RHO, MERTK, EYS, PDE6A, SEMA4A, TULP1, PRPF31, MYO7A, PDE6B, RP1, IDH3B, GUCA1B, IMPDH1, CNGA1, PRPF6, DHDDS, RP2, MAK, PRPF4, NEK2, CA4, RPGR, LRAT, TTC8, PROM1
protein binding (GO:0005515)	0.46	43	CRX, KLHL7, SNRNP200, RDH12, NR2E3, SAG, CNGB1, ZNF408, RGR, PRPF8, BBS2, FSCN2, FAM161A, MERTK, PROM1, CRB1, OFD1, PDE6G, ARL6, TOPORS, USH2A, KIZ, CYGB, PRPF3, NRL, SEMA4A, TULP1, PRPF31, MYO7A, RP1, ZNF513, CNGA1, PRPF6, DHDDS, RP2, MAK, PRPF4, NEK2, CA4, RPGR, RHO, TTC8, RP9
organic cyclic compound binding (GO:0097159)	1.05	28	CRX, PRPF8, MYO7A, NR2E3, TOPORS, CNGB1, ZNF408, SNRNP200, PRPF3, RP9, PANK2, ZNF513, ARL6, ABCA4, RPGR, CYGB, MERTK, NRL, PRPF31, IDH3B, IMPDH1, CNGA1, PRPF6, RP2, MAK, PRPF4, NEK2, PDE6G
heterocyclic compound binding (GO:1901363)	1.06	28	CRX, PRPF8, MYO7A, NR2E3, TOPORS, CYGB, ZNF408, SNRNP200, PRPF3, RP9, PANK2, ZNF513, ARL6, ABCA4, RPGR, CNGB1, MERTK, NRL, PRPF31, IDH3B, IMPDH1, CNGA1, PRPF6, RP2, MAK, PRPF4, NEK2, PDE6G
catalytic activity (GO:0003824)	1.05	24	PRPF8, MYO7A, RDH12, TOPORS, CERKL, SNRNP200, KLHL7, PDE6B, PANK2, RPE65, PDE6G, HGSNAT, ABCA4, CYGB, RBP3, MERTK, PDE6A, IDH3B, IMPDH1, DHDDS, MAK, NEK2, CA4, LRAT
ion binding (GO:0043167)	1.36	20	CYGB, RHO, PDE6B, NR2E3, RP9, PDE6A, NEK2, RPE65, ZNF408, CDHR1, CRB1, LRAT, GUCA1B, ZNF513, CA4, ARL6, TOPORS, IDH3B, EYS, IMPDH1
cation binding (GO:0043169)	1.4	19	CA4, CYGB, PDE6B, PDE6A, RP9, NR2E3, CRB1, TOPORS, ZNF408, RPE65, NEK2, RHO, GUCA1B, ZNF513, CDHR1, ARL6, IDH3B, EYS, IMPDH1
metal ion binding (GO:0046872)	1.41	19	CA4, CYGB, PDE6B, EYS, PDE6A, TOPORS, NR2E3, NEK2, ZNF408, RPE65, CRB1, RHO, GUCA1B, ZNF513, CDHR1, ARL6, IDH3B, RP9, IMPDH1
small molecule binding (GO:0036094)	1.89	17	CNGA1, CNGB1, RBP3, MERTK, RP2, ABCA4, PANK2, NEK2, PDE6G, SNRNP200, MYO7A, MAK, RHO, ARL6, IDH3B, LRAT, IMPDH1
nucleic acid binding (GO:0003676)	1.44	15	CRX, PRPF8, PRPF3, NRL, PRPF4, RP9, NR2E3, ZNF408, PRPF31, RPGR, SNRNP200, ZNF513, PRPF6, TOPORS, IMPDH1
nucleoside phosphate binding (GO:1901265)	1.96	14	CNGA1, CNGB1, MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, PDE6G, SNRNP200, ARL6, IDH3B, MAK, IMPDH1
nucleotide binding (GO:0000166)	1.96	14	CNGA1, CNGB1, MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, PDE6G, SNRNP200, ARL6, IDH3B, MAK, IMPDH1
carbohydrate derivative binding (GO:0097367)	2.03	13	CNGA1, CNGB1, SNRNP200, MERTK, RP2, ABCA4, PANK2, NEK2, PDE6G, IMPG2, MYO7A, ARL6, MAK
purine ribonucleotide binding (GO:0032555)	2.2	12	CNGA1, CNGB1, MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, PDE6G, SNRNP200, ARL6, MAK
purine nucleotide binding (GO:0017076)	2.19	12	CNGA1, CNGB1, MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, PDE6G, SNRNP200, ARL6, MAK
ribonucleotide binding (GO:0032553)	2.19	12	CNGA1, CNGB1, MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, PDE6G, SNRNP200, ARL6, MAK
transferase activity (GO:0016740)	1.95	10	CERKL, KLHL7, MERTK, DHDDS, MAK, PANK2, NEK2, LRAT, HGSNAT, TOPORS
cytoskeletal protein binding (GO:0008092)	3.02	9	FSCN2, RP2, PROM1, TULP1, OFD1, PDE6G, MYO7A, RP1, USH2A
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	9	MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, SNRNP200, ARL6, MAK
RNA binding (GO:0003723)	2.36	9	PRPF8, PRPF3, RP9, PRPF4, PRPF31, RPGR, SNRNP200, PRPF6, IMPDH1
ribonucleoside binding (GO:0032549)	2.22	9	MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, SNRNP200, ARL6, MAK
purine ribonucleoside binding (GO:0032550)	2.22	9	MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, SNRNP200, ARL6, MAK
purine nucleoside binding (GO:0001883)	2.22	9	MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, SNRNP200, ARL6, MAK
nucleoside binding (GO:0001882)	2.21	9	MYO7A, MERTK, RP2, ABCA4, PANK2, NEK2, SNRNP200, ARL6, MAK
hydrolase activity (GO:0016787)	1.9	8	SNRNP200, PDE6B, ABCA4, PDE6A, RPE65, RBP3, PDE6G, MYO7A
adenyl ribonucleotide binding (GO:0032559)	2.41	8	CNGB1, MYO7A, MERTK, ABCA4, PANK2, NEK2, SNRNP200, MAK
adenyl nucleotide binding (GO:0030554)	2.4	8	CNGB1, MYO7A, MERTK, ABCA4, PANK2, NEK2, SNRNP200, MAK
poly(A) RNA binding (GO:0044822)	2.69	7	PRPF8, PRPF3, RP9, PRPF31, SNRNP200, PRPF6, RPGR
identical protein binding (GO:0042802)	2.63	7	KLHL7, MYO7A, PRPF3, OFD1, ZNF408, SNRNP200, USH2A
ATP binding (GO:0005524)	2.43	7	MYO7A, MERTK, ABCA4, PANK2, NEK2, SNRNP200, MAK
DNA binding (GO:0003677)	1.92	7	CRX, NRL, TOPORS, NR2E3, ZNF408, ZNF513, IMPDH1
substrate-specific transporter activity (GO:0022892)	2.72	6	CNGA1, CYGB, SLC7A14, ABCA4, CNGB1, BEST1
transporter activity (GO:0005215)	2.57	6	CNGA1, CYGB, SLC7A14, ABCA4, CNGB1, BEST1
lipid binding (GO:0008289)	3.26	6	RBP3, TULP1, RPE65, RHO, ARL6, LRAT
molecular transducer activity (GO:0060089)	2.32	6	CNGA1, CNGB1, RGR, MERTK, NR2E3, RHO
macromolecular complex binding (GO:0044877)	2.61	6	FSCN2, PRPF6, TULP1, PRPF31, MYO7A, USH2A
receptor activity (GO:0004872)	2.32	6	CNGA1, CNGB1, RGR, MERTK, NR2E3, RHO
guanyl nucleotide binding (GO:0019001)	3.73	5	CNGA1, RP2, CNGB1, PDE6G, ARL6
transferase activity, transferring phosphorus-containing groups (GO:0016772)	2.77	5	MERTK, MAK, PANK2, CERKL, NEK2
kinase activity (GO:0016301)	2.93	5	MERTK, CERKL, PANK2, MAK, NEK2
guanyl ribonucleotide binding (GO:0032561)	3.73	5	CNGA1, RP2, CNGB1, PDE6G, ARL6
transmembrane transporter activity (GO:0022857)	2.82	5	CNGA1, ABCA4, CNGB1, BEST1, SLC7A14
molecular function regulator (GO:0098772)	2.51	5	RP2, SAG, PDE6G, GUCA1B, RPGR
transmembrane receptor activity (GO:0099600)	2.53	5	CNGA1, RHO, CNGB1, MERTK, RGR
oxidoreductase activity (GO:0016491)	3.12	5	IDH3B, CYGB, RPE65, RDH12, IMPDH1
substrate-specific transmembrane transporter activity (GO:0022891)	2.9	4	CNGA1, CNGB1, BEST1, SLC7A14
signaling receptor activity (GO:0038023)	2.49	4	MERTK, NR2E3, RHO, RGR
transition metal ion binding (GO:0046914)	2.48	4	NR2E3, TOPORS, CA4, CYGB
phosphotransferase activity, alcohol group as acceptor (GO:0016773)	3.08	4	MAK, PANK2, MERTK, NEK2
enzyme regulator activity (GO:0030234)	2.85	4	RP2, SAG, PDE6G, GUCA1B
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	4	PDE6A, RPE65, PDE6G, PDE6B
actin binding (GO:0003779)	3.74	4	FSCN2, RP2, TULP1, MYO7A
calcium ion binding (GO:0005509)	3.17	4	EYS, CDHR1, GUCA1B, CRB1
signal transducer activity (GO:0004871)	2.28	4	MERTK, NR2E3, RHO, RGR
protein complex binding (GO:0032403)	3.09	4	FSCN2, TULP1, USH2A, MYO7A
3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114)	6.52	3	PDE6G, PDE6A, PDE6B
enzyme binding (GO:0019899)	2.27	3	KIZ, TOPORS, NEK2
phosphoric ester hydrolase activity (GO:0042578)	3.82	3	PDE6G, PDE6A, PDE6B
zinc ion binding (GO:0008270)	2.66	3	CA4, TOPORS, NR2E3
ATPase activity (GO:0016887)	3.65	3	ABCA4, MYO7A, SNRNP200
sequence-specific DNA binding (GO:0043565)	2.79	3	NRL, CRX, NR2E3
cyclic-nucleotide phosphodiesterase activity (GO:0004112)	6.48	3	PDE6G, PDE6A, PDE6B
phosphoric diester hydrolase activity (GO:0008081)	5.23	3	PDE6G, PDE6A, PDE6B
phospholipid binding (GO:0005543)	3.91	3	TULP1, ARL6, RPE65
3',5'-cyclic-GMP phosphodiesterase activity (GO:0047555)	7.1	3	PDE6G, PDE6A, PDE6B
snRNA binding (GO:0017069)	6.21	3	PRPF4, PRPF31, PRPF8
passive transmembrane transporter activity (GO:0022803)	3.6	3	CNGA1, CNGB1, BEST1
retinoid binding (GO:0005501)	6.1	3	RHO, RBP3, LRAT
RNA polymerase II transcription factor activity, sequence-specific DNA binding (GO:0000981)	3.29	3	NRL, CRX, NR2E3
protein homodimerization activity (GO:0042803)	3.16	3	KLHL7, USH2A, MYO7A
ion channel activity (GO:0005216)	3.71	3	CNGA1, CNGB1, BEST1
protein kinase activity (GO:0004672)	3.27	3	MAK, MERTK, NEK2
regulatory region nucleic acid binding (GO:0001067)	3.03	3	NRL, CRX, ZNF513
cyclic nucleotide binding (GO:0030551)	6.13	3	CNGA1, CNGB1, PDE6G
actin filament binding (GO:0051015)	4.93	3	FSCN2, TULP1, MYO7A
nucleoside-triphosphatase activity (GO:0017111)	3.09	3	ABCA4, MYO7A, SNRNP200
protein domain specific binding (GO:0019904)	3.32	3	NRL, CRX, MYO7A
protein dimerization activity (GO:0046983)	2.72	3	KLHL7, USH2A, MYO7A
cGMP binding (GO:0030553)	6.97	3	CNGA1, CNGB1, PDE6G
transcription regulatory region DNA binding (GO:0044212)	3.03	3	NRL, CRX, ZNF513
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides (GO:0016818)	3.03	3	ABCA4, MYO7A, SNRNP200
oxidoreductase activity, acting on CH-OH group of donors (GO:0016614)	4.83	3	IDH3B, RDH12, IMPDH1
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)	5.0	3	IDH3B, RDH12, IMPDH1
transcription factor activity, sequence-specific DNA binding (GO:0003700)	2.65	3	NRL, CRX, NR2E3
ATPase activity, coupled (GO:0042623)	3.97	3	ABCA4, MYO7A, SNRNP200
isoprenoid binding (GO:0019840)	6.05	3	RHO, RBP3, LRAT
hydrolase activity, acting on acid anhydrides (GO:0016817)	3.03	3	ABCA4, MYO7A, SNRNP200
vitamin binding (GO:0019842)	5.34	3	RHO, RBP3, LRAT
ion transmembrane transporter activity (GO:0015075)	3.04	3	CNGA1, CNGB1, BEST1
pyrophosphatase activity (GO:0016462)	3.04	3	ABCA4, MYO7A, SNRNP200
transmembrane signaling receptor activity (GO:0004888)	2.57	3	MERTK, RHO, RGR
channel activity (GO:0015267)	3.6	3	CNGA1, CNGB1, BEST1
gated channel activity (GO:0022836)	3.96	3	CNGA1, CNGB1, BEST1
regulatory region DNA binding (GO:0000975)	3.03	3	NRL, CRX, ZNF513
receptor binding (GO:0005102)	2.43	3	SEMA4A, PRPF6, CRX
substrate-specific channel activity (GO:0022838)	3.67	3	CNGA1, CNGB1, BEST1
nucleic acid binding transcription factor activity (GO:0001071)	2.65	3	NRL, CRX, NR2E3
repressing transcription factor binding (GO:0070491)	5.71	2	BBS2, TTC8
potassium channel activity (GO:0005267)	4.94	2	CNGA1, CNGB1
cation channel activity (GO:0005261)	4.04	2	CNGA1, CNGB1
cyclic nucleotide-gated ion channel activity (GO:0043855)	7.34	2	CNGA1, CNGB1
intracellular cyclic nucleotide activated cation channel activity (GO:0005221)	7.34	2	CNGA1, CNGB1
intracellular cGMP activated cation channel activity (GO:0005223)	7.79	2	CNGA1, CNGB1
intracellular cAMP activated cation channel activity (GO:0005222)	7.54	2	CNGA1, CNGB1
RNA polymerase II regulatory region DNA binding (GO:0001012)	3.36	2	NRL, CRX
core promoter proximal region DNA binding (GO:0001159)	3.82	2	NRL, CRX
ligand-gated ion channel activity (GO:0015276)	4.8	2	CNGA1, CNGB1
leucine zipper domain binding (GO:0043522)	7.34	2	NRL, CRX
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0001077)	4.31	2	NRL, CRX
enzyme activator activity (GO:0008047)	3.56	2	RP2, GUCA1B
enzyme inhibitor activity (GO:0004857)	3.78	2	SAG, PDE6G
retinal binding (GO:0016918)	7.1	2	RHO, RBP3
ubiquitin-like protein transferase activity (GO:0019787)	3.69	2	TOPORS, KLHL7
G-protein coupled receptor activity (GO:0004930)	2.95	2	RHO, RGR
sequence-specific double-stranded DNA binding (GO:1990837)	3.2	2	NRL, CRX
U4 snRNA binding (GO:0030621)	8.13	2	PRPF31, PRPF4
transcription coactivator activity (GO:0003713)	4.04	2	MAK, PRPF6
transcription cofactor activity (GO:0003712)	3.44	2	MAK, PRPF6
structural molecule activity (GO:0005198)	3.1	2	GUCA1B, IMPG2
protein serine/threonine kinase activity (GO:0004674)	3.64	2	MAK, NEK2
transferase activity, transferring acyl groups (GO:0016746)	4.2	2	HGSNAT, LRAT
transferase activity, transferring acyl groups other than amino-acyl groups (GO:0016747)	4.37	2	HGSNAT, LRAT
transcription factor activity, transcription factor binding (GO:0000989)	3.36	2	MAK, PRPF6
transcription factor activity, protein binding (GO:0000988)	3.35	2	MAK, PRPF6
ribonucleoprotein complex binding (GO:0043021)	5.15	2	PRPF31, PRPF6
metal ion transmembrane transporter activity (GO:0046873)	3.71	2	CNGA1, CNGB1
spectrin binding (GO:0030507)	6.48	2	PDE6G, MYO7A
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding (GO:0000982)	3.94	2	NRL, CRX
active transmembrane transporter activity (GO:0022804)	3.85	2	ABCA4, SLC7A14
GTP binding (GO:0005525)	3.78	2	RP2, ARL6
tubulin binding (GO:0015631)	4.1	2	RP1, OFD1
intracellular ligand-gated ion channel activity (GO:0005217)	6.41	2	CNGA1, CNGB1
photoreceptor activity (GO:0009881)	6.97	2	RHO, RGR
transcription factor binding (GO:0008134)	3.46	2	BBS2, TTC8
cation transmembrane transporter activity (GO:0008324)	3.32	2	CNGA1, CNGB1
nuclear hormone receptor binding (GO:0035257)	4.7	2	CRX, PRPF6
core promoter proximal region sequence-specific DNA binding (GO:0000987)	3.83	2	NRL, CRX
RNA polymerase II repressing transcription factor binding (GO:0001103)	6.44	2	BBS2, TTC8
LRR domain binding (GO:0030275)	6.91	2	NRL, CRX
hormone receptor binding (GO:0051427)	4.57	2	CRX, PRPF6
ubiquitin-protein transferase activity (GO:0004842)	3.73	2	TOPORS, KLHL7
double-stranded DNA binding (GO:0003690)	3.09	2	NRL, CRX
retinol binding (GO:0019841)	7.17	2	RBP3, LRAT
RNA polymerase II transcription factor binding (GO:0001085)	5.08	2	BBS2, TTC8
inorganic cation transmembrane transporter activity (GO:0022890)	3.49	2	CNGA1, CNGB1
voltage-gated ion channel activity (GO:0005244)	4.49	2	CNGA1, CNGB1
dioxygenase activity (GO:0051213)	5.25	2	CYGB, RPE65
alcohol binding (GO:0043178)	5.53	2	RBP3, LRAT
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding (GO:0001228)	3.98	2	NRL, CRX
voltage-gated channel activity (GO:0022832)	4.49	2	CNGA1, CNGB1
monovalent inorganic cation transmembrane transporter activity (GO:0015077)	3.87	2	CNGA1, CNGB1
transcription regulatory region sequence-specific DNA binding (GO:0000976)	3.24	2	NRL, CRX
RNA polymerase II regulatory region sequence-specific DNA binding (GO:0000977)	3.37	2	NRL, CRX
voltage-gated potassium channel activity (GO:0005249)	5.24	2	CNGA1, CNGB1
ligand-gated channel activity (GO:0022834)	4.8	2	CNGA1, CNGB1
voltage-gated cation channel activity (GO:0022843)	4.83	2	CNGA1, CNGB1
RNA polymerase II core promoter proximal region sequence-specific DNA binding (GO:0000978)	3.88	2	NRL, CRX
U6 snRNA binding (GO:0017070)	7.44	2	PRPF4, PRPF8
potassium ion transmembrane transporter activity (GO:0015079)	4.77	2	CNGA1, CNGB1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cGMP binding (GO:0030553)	-	6.97	0.003	CNGA1, CNGB1, PDE6G, PDE6B
cyclic nucleotide binding (GO:0030551)	-	6.13	0.043	CNGA1, CNGB1, PDE6G, PDE6B
photoreceptor activity (GO:0009881)	-	6.97	0.006	TULP1, RHO, RGR
3',5'-cyclic-nucleotide phosphodiesterase activity (GO:0004114)	-	6.52	0.029	PDE6G, CNGB1, PDE6A, PDE6B
isoprenoid binding (GO:0019840)	-	6.05	0.04	RHO, RBP3, LRAT
cyclic-nucleotide phosphodiesterase activity (GO:0004112)	-	6.48	0.015	PDE6G, CNGB1, PDE6A, PDE6B
3',5'-cyclic-GMP phosphodiesterase activity (GO:0047555)	-	7.1	0.0	PDE6G, CNGB1, PDE6A, PDE6B
leucine zipper domain binding (GO:0043522)	-	7.34	0.002	NRL, CRX, RHO
retinoid binding (GO:0005501)	-	6.1	0.04	RHO, RBP3, LRAT

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	61	CRX, PRPF8, RGR, RDH12, NR2E3, TOPORS, CERKL, ZNF408, CDHR1, SNRNP200, KLHL7, BBS2, ABCA4, FSCN2, FAM161A, PRPF3, RP9, CYGB, RBP3, CRB1, OFD1, RPE65, ZNF513, ROM1, PDE6G, ARL6, CLRN1, SAG, USH2A, KIZ, CNGB1, LRAT, MERTK, NRL, RP1L1, SEMA4A, PANK2, TULP1, PRPF31, MYO7A, PDE6B, RP1, IDH3B, HGSNAT, IMPDH1, CNGA1, IFT172, PRPF6, DHDDS, MAK, RP2, IFT140, PRPF4, NEK2, PDE6A, CA4, RPGR, RHO, GUCA1B, TTC8, PROM1
single-organism process (GO:0044699)	0.48	50	CRX, PDE6A, BEST1, RDH12, TOPORS, CNGB1, CDHR1, SNRNP200, BBS2, ABCA4, FSCN2, FAM161A, PDE6B, PROM1, PANK2, CRB1, SLC7A14, OFD1, RPE65, ROM1, ARL6, CLRN1, EYS, RPGR, KIZ, CYGB, RBP3, MERTK, NRL, RP1L1, SEMA4A, TULP1, MYO7A, MAK, RHO, RP1, IDH3B, GUCA1B, IMPDH1, CNGA1, IFT172, DHDDS, RP2, IFT140, NR2E3, NEK2, CA4, USH2A, LRAT, TTC8
single-organism cellular process (GO:0044763)	0.65	46	CRX, MYO7A, RDH12, TOPORS, CYGB, SNRNP200, BBS2, FSCN2, FAM161A, RP1L1, PDE6B, PROM1, PANK2, CRB1, OFD1, RPE65, ROM1, ARL6, CLRN1, ABCA4, RPGR, KIZ, CNGB1, RBP3, MERTK, NRL, TULP1, SEMA4A, PDE6A, MAK, RHO, RP1, IDH3B, GUCA1B, IMPDH1, CNGA1, IFT172, DHDDS, RP2, IFT140, NR2E3, NEK2, CA4, USH2A, LRAT, TTC8
multicellular organismal process (GO:0032501)	1.45	45	CRX, IMPG2, RDH12, SAG, CDHR1, RGR, PRPH2, BBS2, ABCA4, FSCN2, FAM161A, RP9, PDE6A, RBP3, PRCD, RPE65, ROM1, ARL6, CLRN1, EYS, USH2A, BEST1, CNGB1, LRAT, PDE6B, NRL, TULP1, SEMA4A, RP1L1, MYO7A, MAK, RP1, GUCA1B, ZNF513, CNGA1, IFT172, RP2, IFT140, NR2E3, C2orf71, PDE6G, RPGR, RHO, TTC8, PROM1
biological regulation (GO:0065007)	0.39	44	CRX, PDE6A, BEST1, RDH12, CYGB, SAG, CERKL, ZNF408, RGR, PRPH2, BBS2, ABCA4, PDE6B, PROM1, PANK2, SLC7A14, RPE65, ROM1, ARL6, CLRN1, TOPORS, USH2A, CNGB1, RHO, MERTK, NRL, RP1L1, SEMA4A, TULP1, MAK, RP1, GUCA1B, ZNF513, CNGA1, IFT172, PRPF6, RP2, IFT140, NR2E3, NEK2, PDE6G, RPGR, LRAT, TTC8
regulation of biological process (GO:0050789)	0.45	41	CRX, BEST1, CYGB, SAG, CERKL, ZNF408, RGR, PRPH2, BBS2, ABCA4, PDE6B, PROM1, PANK2, RPE65, ROM1, ARL6, CLRN1, TOPORS, USH2A, CNGB1, SLC7A14, MERTK, NRL, RP1L1, SEMA4A, TULP1, MAK, RHO, RP1, GUCA1B, ZNF513, CNGA1, IFT172, PRPF6, PDE6A, IFT140, NR2E3, NEK2, PDE6G, LRAT, TTC8
neurological system process (GO:0050877)	2.64	39	CRX, IMPG2, RDH12, SAG, RGR, PRPH2, BBS2, FSCN2, FAM161A, RP9, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, RPGR, BEST1, CNGB1, RBP3, PDE6B, NRL, TULP1, EYS, RP1L1, MYO7A, RHO, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, USH2A, LRAT, TTC8
system process (GO:0003008)	2.3	39	CRX, IMPG2, RDH12, SAG, RGR, PRPH2, BBS2, FSCN2, FAM161A, RP9, PDE6A, RBP3, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, USH2A, BEST1, CNGB1, LRAT, PDE6B, NRL, TULP1, EYS, RP1L1, MYO7A, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, RPGR, RHO, TTC8
sensory perception (GO:0007600)	2.93	38	CRX, IMPG2, RDH12, SAG, RGR, PRPH2, LRAT, FSCN2, FAM161A, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, RPGR, BEST1, CNGB1, BBS2, RBP3, PDE6B, NRL, TULP1, EYS, RP1L1, MYO7A, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, USH2A, RHO, TTC8
regulation of cellular process (GO:0050794)	0.5	38	CRX, CYGB, SAG, CERKL, ZNF408, RGR, PRPH2, BBS2, ABCA4, PDE6B, PROM1, PANK2, RPE65, ARL6, CLRN1, TOPORS, USH2A, CNGB1, RHO, MERTK, NRL, RP1L1, SEMA4A, TULP1, MAK, RP1, GUCA1B, ZNF513, CNGA1, IFT172, PRPF6, PDE6A, IFT140, NR2E3, NEK2, PDE6G, SLC7A14, TTC8
visual perception (GO:0007601)	4.41	37	CRX, IMPG2, RDH12, SAG, RGR, PRPH2, LRAT, FSCN2, FAM161A, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, USH2A, BEST1, CNGB1, BBS2, RBP3, PDE6B, NRL, TULP1, EYS, RP1L1, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, RPGR, RHO, MYO7A
sensory perception of light stimulus (GO:0050953)	4.4	37	CRX, IMPG2, RDH12, SAG, RGR, PRPH2, BBS2, FSCN2, FAM161A, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, USH2A, BEST1, CNGB1, RBP3, PDE6B, NRL, TULP1, EYS, RP1L1, RHO, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, RPGR, LRAT, MYO7A
response to stimulus (GO:0050896)	1.22	35	CRX, PRPF8, BEST1, RDH12, SAG, CYGB, RGR, BBS2, ABCA4, FAM161A, PRCD, NRL, RPE65, ZNF513, ARL6, CLRN1, TOPORS, RPGR, CNGB1, LRAT, PDE6B, EYS, RP1L1, SEMA4A, TULP1, RP1, GUCA1B, IMPDH1, CNGA1, PDE6A, NR2E3, C2orf71, PDE6G, USH2A, RHO
metabolic process (GO:0008152)	0.58	35	CRX, KLHL7, RGR, RDH12, NR2E3, TOPORS, CYGB, ZNF408, SNRNP200, PRPF8, MERTK, RP9, PANK2, RPE65, IMPDH1, HGSNAT, ABCA4, CERKL, RBP3, PRPF3, NRL, PDE6A, PRPF31, PDE6B, RHO, IDH3B, ZNF513, IFT172, PRPF6, DHDDS, MAK, PRPF4, NEK2, CA4, LRAT
developmental process (GO:0032502)	1.36	33	CRX, TOPORS, MYO7A, PRPH2, BBS2, FSCN2, FAM161A, PDE6B, PROM1, PANK2, CRB1, OFD1, RPE65, IMPDH1, ROM1, ARL6, EYS, RPGR, MERTK, NRL, TULP1, SEMA4A, RP1L1, MAK, RP1, ZNF513, IFT172, RP2, IFT140, NR2E3, NEK2, RHO, TTC8
organic substance metabolic process (GO:0071704)	0.63	33	CRX, KLHL7, RGR, RDH12, NR2E3, TOPORS, ZNF408, SNRNP200, PRPF8, MERTK, RP9, PANK2, RPE65, IMPDH1, HGSNAT, ABCA4, CYGB, LRAT, PRPF3, NRL, PDE6A, PRPF31, PDE6B, RHO, IDH3B, ZNF513, IFT172, PRPF6, DHDDS, MAK, PRPF4, NEK2, RBP3
cellular metabolic process (GO:0044237)	0.69	33	CRX, KLHL7, RGR, RDH12, NR2E3, TOPORS, CERKL, ZNF408, SNRNP200, PRPF8, MERTK, RP9, PANK2, RPE65, IMPDH1, ABCA4, CYGB, RBP3, PRPF3, NRL, PDE6A, PRPF31, PDE6B, RHO, IDH3B, ZNF513, PRPF6, DHDDS, MAK, PRPF4, NEK2, CA4, LRAT
primary metabolic process (GO:0044238)	0.69	32	CRX, KLHL7, RGR, RDH12, NR2E3, TOPORS, ZNF408, SNRNP200, PRPF8, PRPF3, RP9, PANK2, RPE65, IMPDH1, ABCA4, CYGB, RBP3, MERTK, NRL, PDE6A, PRPF31, PDE6B, RHO, IDH3B, ZNF513, IFT172, PRPF6, DHDDS, MAK, PRPF4, NEK2, LRAT
cellular component organization (GO:0016043)	1.24	30	PRPF8, MYO7A, TOPORS, SNRNP200, BBS2, FSCN2, FAM161A, MERTK, PANK2, CRB1, OFD1, ARL6, CLRN1, ABCA4, RPGR, KIZ, CNGB1, PRPF3, RP1L1, SEMA4A, TULP1, PRPF31, RP1, HGSNAT, IFT172, PRPF6, RP2, IFT140, NEK2, TTC8
cellular component organization or biogenesis (GO:0071840)	1.22	30	PRPF8, MYO7A, TOPORS, SNRNP200, BBS2, FSCN2, FAM161A, MERTK, PANK2, CRB1, OFD1, ARL6, CLRN1, ABCA4, RPGR, KIZ, CNGB1, PRPF3, RP1L1, SEMA4A, TULP1, PRPF31, RP1, HGSNAT, IFT172, PRPF6, RP2, IFT140, NEK2, TTC8
single-organism developmental process (GO:0044767)	1.49	28	CRX, TOPORS, MYO7A, BBS2, FSCN2, FAM161A, PROM1, PANK2, CRB1, OFD1, RPE65, ROM1, ARL6, SEMA4A, RPGR, MERTK, NRL, TULP1, EYS, RP1L1, MAK, RP1, IFT172, RP2, IFT140, NR2E3, NEK2, TTC8
anatomical structure development (GO:0048856)	1.58	28	CRX, TOPORS, MYO7A, PRPH2, BBS2, FSCN2, PDE6B, PANK2, CRB1, RPE65, IMPDH1, ROM1, ARL6, SEMA4A, MERTK, NRL, TULP1, EYS, RP1L1, MAK, RP1, ZNF513, IFT172, IFT140, NR2E3, NEK2, RHO, TTC8
cellular developmental process (GO:0048869)	1.82	25	CRX, MYO7A, TOPORS, SNRNP200, BBS2, FSCN2, PROM1, PANK2, CRB1, OFD1, ROM1, ARL6, MAK, USH2A, MERTK, NRL, TULP1, SEMA4A, RP1L1, RP1, IFT172, RP2, IFT140, NR2E3, TTC8
localization (GO:0051179)	1.4	23	MYO7A, TOPORS, CNGB1, BEST1, ARL6, ABCA4, USH2A, CYGB, RBP3, MERTK, TULP1, PRPF31, BBS2, HGSNAT, CNGA1, PRPF6, RP2, IFT140, CA4, RPGR, SLC7A14, GUCA1B, TTC8
macromolecule metabolic process (GO:0043170)	0.83	23	CRX, KLHL7, SNRNP200, PRPF4, TOPORS, ZNF408, RGR, PRPF8, MERTK, RP9, HGSNAT, MAK, RHO, PRPF3, NRL, PRPF31, ZNF513, IFT172, PRPF6, DHDDS, NR2E3, NEK2, RBP3
signal transduction (GO:0007165)	1.28	21	CNGA1, CNGB1, RP1L1, RGR, PDE6B, MERTK, NR2E3, SAG, PDE6A, IFT172, ARL6, SEMA4A, RPE65, RHO, GUCA1B, PDE6G, RP1, TOPORS, PRPH2, BBS2, ABCA4
establishment of localization (GO:0051234)	1.48	20	CNGA1, BEST1, CYGB, GUCA1B, RBP3, MERTK, RP2, IFT140, TULP1, CNGB1, ARL6, HGSNAT, CA4, RPGR, SLC7A14, MYO7A, BBS2, TTC8, USH2A, ABCA4
nitrogen compound metabolic process (GO:0006807)	1.13	20	CRX, PRPF4, PRPF8, PDE6B, PRPF3, NRL, PDE6A, RP9, PANK2, ZNF408, PRPF6, PRPF31, TOPORS, ZNF513, SNRNP200, NR2E3, HGSNAT, IDH3B, MAK, IMPDH1
single-multicellular organism process (GO:0044707)	1.78	20	CNGB1, SEMA4A, RDH12, NRL, RP1L1, IFT140, TULP1, CRX, ARL6, PROM1, CDHR1, TTC8, RHO, CLRN1, MAK, RP1, IFT172, BBS2, USH2A, ABCA4
cellular macromolecule metabolic process (GO:0044260)	0.93	20	RGR, CRX, KLHL7, SNRNP200, DHDDS, NRL, NR2E3, RP9, PRPF4, PRPF31, NEK2, ZNF408, TOPORS, RHO, PRPF3, PRPF8, PRPF6, MERTK, MAK, ZNF513
nucleobase-containing compound metabolic process (GO:0006139)	1.35	19	CRX, PRPF4, PRPF8, PDE6B, PRPF3, NRL, PDE6A, RP9, PANK2, ZNF408, PRPF6, PRPF31, ZNF513, SNRNP200, NR2E3, TOPORS, IDH3B, MAK, IMPDH1
cellular component assembly (GO:0022607)	2.14	19	FSCN2, FAM161A, PRPF8, MYO7A, PRPF3, IFT140, RP1L1, IFT172, NEK2, ARL6, OFD1, PRPF31, HGSNAT, TTC8, SNRNP200, PRPF6, RP1, BBS2, RPGR
transport (GO:0006810)	1.51	19	CNGA1, BEST1, CYGB, GUCA1B, RBP3, MERTK, RP2, IFT140, TULP1, CNGB1, ARL6, HGSNAT, CA4, SLC7A14, MYO7A, BBS2, TTC8, RPGR, ABCA4
cellular aromatic compound metabolic process (GO:0006725)	1.3	19	CRX, PRPF4, PRPF6, PRPF3, PDE6B, NRL, PDE6A, RP9, PANK2, PRPF31, NR2E3, ZNF408, ZNF513, SNRNP200, PRPF8, TOPORS, IDH3B, MAK, IMPDH1
cellular nitrogen compound metabolic process (GO:0034641)	1.22	19	CRX, PRPF4, PRPF8, PDE6B, PRPF3, NRL, PDE6A, RP9, PANK2, ZNF408, PRPF6, PRPF31, ZNF513, SNRNP200, NR2E3, TOPORS, IDH3B, MAK, IMPDH1
organic cyclic compound metabolic process (GO:1901360)	1.26	19	CRX, PRPF8, PDE6B, PRPF3, NRL, PRPF4, RP9, PDE6A, PANK2, PRPF31, PRPF6, ZNF408, ZNF513, SNRNP200, NR2E3, TOPORS, IDH3B, MAK, IMPDH1
heterocycle metabolic process (GO:0046483)	1.31	19	CRX, PRPF4, PRPF6, PRPF3, PDE6B, NRL, PDE6A, RP9, PANK2, PRPF31, NR2E3, ZNF408, ZNF513, SNRNP200, PRPF8, TOPORS, IDH3B, MAK, IMPDH1
organelle organization (GO:0006996)	2.02	18	KIZ, FSCN2, FAM161A, RP2, RP1L1, IFT140, PANK2, CNGB1, NEK2, ARL6, OFD1, TOPORS, TTC8, MYO7A, RP1, IFT172, BBS2, RPGR
response to abiotic stimulus (GO:0009628)	2.8	18	CNGA1, BEST1, CNGB1, RHO, PDE6B, PDE6A, TULP1, SAG, NR2E3, CYGB, RPE65, RGR, GUCA1B, PDE6G, RP1, EYS, IMPDH1, ABCA4
regulation of metabolic process (GO:0019222)	1.02	17	CYGB, PRPF6, ROM1, NRL, NR2E3, MAK, PANK2, CRX, NEK2, TOPORS, ZNF408, RPE65, SLC7A14, PDE6G, BBS2, GUCA1B, ZNF513
response to external stimulus (GO:0009605)	2.55	17	CNGA1, BEST1, CNGB1, PRPF8, RHO, PDE6B, PDE6A, SAG, TULP1, NR2E3, RPE65, RGR, GUCA1B, PDE6G, RP1, EYS, ABCA4
detection of external stimulus (GO:0009581)	4.98	16	CNGA1, BEST1, CNGB1, RHO, PDE6B, EYS, PDE6A, SAG, TULP1, NR2E3, RPE65, RGR, GUCA1B, PDE6G, RP1, ABCA4
detection of abiotic stimulus (GO:0009582)	4.96	16	CNGA1, BEST1, CNGB1, RHO, PDE6B, EYS, PDE6A, SAG, TULP1, NR2E3, RPE65, RGR, GUCA1B, PDE6G, RP1, ABCA4
detection of light stimulus (GO:0009583)	5.67	16	CNGA1, BEST1, CNGB1, RHO, PDE6B, EYS, PDE6A, SAG, TULP1, NR2E3, RPE65, RGR, GUCA1B, PDE6G, RP1, ABCA4
detection of stimulus (GO:0051606)	3.22	16	CNGA1, BEST1, CNGB1, RHO, PDE6B, EYS, PDE6A, SAG, TULP1, NR2E3, RPE65, RGR, GUCA1B, PDE6G, RP1, ABCA4
response to radiation (GO:0009314)	3.69	16	CNGA1, BEST1, CNGB1, RHO, PDE6B, PDE6A, SAG, TULP1, NR2E3, RPE65, RGR, GUCA1B, PDE6G, RP1, EYS, ABCA4
single-organism organelle organization (GO:1902589)	2.68	16	KIZ, FSCN2, FAM161A, RP1L1, IFT140, PANK2, CNGB1, NEK2, ARL6, OFD1, TOPORS, TTC8, RP1, IFT172, BBS2, RPGR
response to light stimulus (GO:0009416)	4.08	16	CNGA1, BEST1, CNGB1, RHO, PDE6B, PDE6A, SAG, TULP1, NR2E3, RPE65, RGR, GUCA1B, PDE6G, RP1, EYS, ABCA4
positive regulation of biological process (GO:0048518)	1.2	16	IFT172, PRPF6, MERTK, NRL, NR2E3, PROM1, TULP1, CRX, NEK2, TOPORS, PDE6G, LRAT, GUCA1B, BBS2, CLRN1, SEMA4A
cell projection organization (GO:0030030)	3.14	15	CNGB1, SEMA4A, RP1L1, IFT140, TULP1, FAM161A, ARL6, OFD1, TOPORS, TTC8, MYO7A, RP1, IFT172, BBS2, RPGR
regulation of biological quality (GO:0065008)	1.68	15	CNGA1, CNGB1, RDH12, PDE6B, PDE6A, PANK2, ABCA4, TULP1, NEK2, TOPORS, RPE65, LRAT, GUCA1B, BBS2, SEMA4A
single-organism localization (GO:1902578)	2.09	15	CNGA1, BEST1, CNGB1, SLC7A14, MERTK, IFT140, TULP1, CYGB, TOPORS, ABCA4, GUCA1B, BBS2, ARL6, RPGR, MYO7A
RNA metabolic process (GO:0016070)	1.59	14	CRX, PRPF8, PRPF3, NRL, PRPF4, RP9, NR2E3, ZNF408, PRPF31, SNRNP200, PRPF6, TOPORS, MAK, ZNF513
single-organism metabolic process (GO:0044710)	1.63	14	CYGB, PDE6B, DHDDS, PANK2, ABCA4, PDE6A, RBP3, RDH12, RPE65, RHO, CA4, IDH3B, LRAT, IMPDH1
regulation of macromolecule metabolic process (GO:0060255)	1.08	14	CYGB, PRPF6, NRL, MAK, NR2E3, CRX, NEK2, ZNF408, RPE65, ROM1, PDE6G, BBS2, TOPORS, ZNF513
nucleic acid metabolic process (GO:0090304)	1.46	14	CRX, PRPF8, PRPF3, NRL, PRPF4, RP9, NR2E3, ZNF408, PRPF31, SNRNP200, PRPF6, TOPORS, MAK, ZNF513
single-organism transport (GO:0044765)	2.18	14	CNGA1, CYGB, BBS2, BEST1, MERTK, IFT140, TULP1, CNGB1, GUCA1B, SLC7A14, MYO7A, ARL6, ABCA4, RPGR
anatomical structure morphogenesis (GO:0009653)	2.53	14	FSCN2, CRX, MYO7A, MERTK, RP2, IFT140, PANK2, IFT172, OFD1, SEMA4A, RPE65, ROM1, BBS2, PROM1
positive regulation of cellular process (GO:0048522)	1.3	14	CRX, PRPF6, MERTK, NRL, NR2E3, PROM1, TULP1, IFT172, NEK2, PDE6G, GUCA1B, TOPORS, CLRN1, SEMA4A
regulation of cellular metabolic process (GO:0031323)	1.07	13	CRX, PRPF6, NRL, NR2E3, TOPORS, PANK2, NEK2, ZNF408, PDE6G, SLC7A14, GUCA1B, MAK, ZNF513
cell differentiation (GO:0030154)	2.14	13	IFT172, ROM1, MERTK, SEMA4A, PROM1, CRX, ARL6, SNRNP200, MYO7A, MAK, BBS2, TTC8, USH2A
regulation of response to stimulus (GO:0048583)	1.54	13	CNGA1, IFT172, PDE6B, SEMA4A, IFT140, PDE6A, CNGB1, ARL6, PDE6G, RHO, GUCA1B, BBS2, SAG
photoreceptor cell maintenance (GO:0045494)	6.17	13	CNGB1, RDH12, RP1L1, ABCA4, TULP1, PROM1, CDHR1, RHO, MAK, RP1, CLRN1, BBS2, USH2A
regulation of primary metabolic process (GO:0080090)	1.08	12	CRX, PRPF6, NRL, NR2E3, MAK, PANK2, NEK2, ZNF408, PDE6G, GUCA1B, TOPORS, ZNF513
phototransduction (GO:0007602)	5.99	12	CNGA1, CNGB1, RHO, PDE6B, NR2E3, SAG, PDE6A, PDE6G, RGR, GUCA1B, RP1, ABCA4
retina development in camera-type eye (GO:0060041)	5.51	12	RP1L1, PDE6B, MERTK, NR2E3, IFT140, TULP1, RPE65, ZNF513, RHO, RP1, PRPH2, IMPDH1
cell surface receptor signaling pathway (GO:0007166)	2.09	12	IFT172, MERTK, PDE6B, SEMA4A, SAG, PDE6A, PDE6G, GUCA1B, RPE65, BBS2, PRPH2, ARL6
negative regulation of biological process (GO:0048519)	1.33	12	CYGB, MERTK, NR2E3, SEMA4A, CERKL, IFT172, NEK2, TOPORS, SLC7A14, BBS2, TTC8, USH2A
macromolecule localization (GO:0033036)	2.34	12	CNGB1, PRPF6, RP2, IFT140, TULP1, ARL6, PRPF31, TOPORS, MYO7A, BBS2, TTC8, RPGR
anatomical structure formation involved in morphogenesis (GO:0048646)	3.01	12	FAM161A, SEMA4A, IFT140, RP1L1, IFT172, ARL6, PROM1, TOPORS, TTC8, RP1, BBS2, RPGR
phosphorus metabolic process (GO:0006793)	2.15	11	CERKL, PDE6B, DHDDS, MERTK, PDE6A, MAK, PANK2, NEK2, RHO, IDH3B, IMPDH1
regulation of signal transduction (GO:0009966)	1.84	11	CNGA1, IFT172, PDE6B, IFT140, PDE6A, CNGB1, PDE6G, RHO, GUCA1B, ARL6, SAG
regulation of signaling (GO:0023051)	1.72	11	CNGA1, IFT172, PDE6B, IFT140, PDE6A, CNGB1, PDE6G, RHO, GUCA1B, ARL6, SAG
regulation of biosynthetic process (GO:0009889)	1.37	11	CYGB, PRPF6, NRL, MAK, NR2E3, CRX, NEK2, ZNF408, GUCA1B, TOPORS, ZNF513
phosphate-containing compound metabolic process (GO:0006796)	2.16	11	CERKL, DHDDS, PDE6B, MERTK, PDE6A, MAK, PANK2, NEK2, RHO, IDH3B, IMPDH1
organic substance transport (GO:0071702)	2.15	11	ABCA4, BEST1, MYO7A, RP2, IFT140, ARL6, CA4, SLC7A14, TTC8, BBS2, RPGR
regulation of cell communication (GO:0010646)	1.73	11	CNGA1, IFT172, PDE6B, IFT140, PDE6A, CNGB1, PDE6G, RHO, GUCA1B, ARL6, SAG
regulation of gene expression (GO:0010468)	1.37	11	CRX, PRPF6, NRL, MAK, NR2E3, ZNF408, RPE65, ROM1, BBS2, TOPORS, ZNF513
organic substance biosynthetic process (GO:1901576)	1.34	10	CRX, DHDDS, NRL, PANK2, MAK, NR2E3, ZNF408, ZNF513, TOPORS, IMPDH1
cellular response to stimulus (GO:0051716)	1.97	10	CNGA1, CNGB1, PRPF8, PDE6B, SAG, PDE6A, RPE65, RHO, PDE6G, TOPORS
protein localization (GO:0008104)	2.36	10	CNGB1, RP2, IFT140, TULP1, ARL6, TOPORS, MYO7A, TTC8, BBS2, RPGR
regulation of response to external stimulus (GO:0032101)	3.06	10	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B, BBS2, SEMA4A
protein metabolic process (GO:0019538)	1.45	10	IFT172, KLHL7, RHO, DHDDS, MERTK, MAK, RBP3, NEK2, RGR, TOPORS
regulation of cellular biosynthetic process (GO:0031326)	1.38	10	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2, ZNF408, GUCA1B, MAK, ZNF513
regulation of catalytic activity (GO:0050790)	1.97	10	CYGB, RP2, SAG, NEK2, PDE6G, SLC7A14, GUCA1B, TTC8, TOPORS, RPGR
cell development (GO:0048468)	3.28	10	FSCN2, RP1L1, NRL, NR2E3, TOPORS, PANK2, TULP1, CRB1, MYO7A, RP1
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	10	CRX, PRPF6, NRL, MAK, NR2E3, NEK2, ZNF408, GUCA1B, TOPORS, ZNF513
biosynthetic process (GO:0009058)	1.32	10	CRX, DHDDS, NRL, PANK2, MAK, NR2E3, ZNF408, ZNF513, TOPORS, IMPDH1
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	10	CYGB, PRPF6, NRL, MAK, NR2E3, CRX, NEK2, ZNF408, TOPORS, ZNF513
organelle assembly (GO:0070925)	3.75	10	FAM161A, IFT140, IFT172, NEK2, ARL6, OFD1, MYO7A, TTC8, BBS2, RPGR
small molecule metabolic process (GO:0044281)	2.38	10	CYGB, RDH12, PDE6B, PANK2, PDE6A, CA4, LRAT, RPE65, IDH3B, IMPDH1
regulation of molecular function (GO:0065009)	1.78	10	CYGB, RP2, SAG, NEK2, PDE6G, SLC7A14, GUCA1B, TTC8, TOPORS, RPGR
cilium organization (GO:0044782)	4.67	10	FAM161A, IFT140, CNGB1, ARL6, TOPORS, TTC8, RP1, IFT172, BBS2, RPGR
cellular biosynthetic process (GO:0044249)	1.37	10	CRX, DHDDS, NRL, PANK2, MAK, NR2E3, ZNF408, ZNF513, TOPORS, IMPDH1
negative regulation of cellular process (GO:0048523)	1.41	10	CYGB, MERTK, NR2E3, SEMA4A, CERKL, IFT172, NEK2, SLC7A14, TOPORS, USH2A
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	10	CRX, PRPF6, NRL, MAK, NR2E3, NEK2, ZNF408, GUCA1B, TOPORS, ZNF513
neuron development (GO:0048666)	4.8	9	FSCN2, NRL, RP1L1, TOPORS, NR2E3, CRB1, MYO7A, TULP1, RP1
photoreceptor cell development (GO:0042461)	6.17	9	FSCN2, NRL, RP1L1, TOPORS, NR2E3, CRB1, MYO7A, TULP1, RP1
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	9	CRX, NRL, PANK2, MAK, NR2E3, ZNF408, ZNF513, TOPORS, IMPDH1
detection of visible light (GO:0009584)	6.23	9	CNGB1, BEST1, PDE6B, ABCA4, TULP1, RPE65, RHO, RP1, EYS
cell projection assembly (GO:0030031)	4.19	9	IFT172, BBS2, IFT140, RP1L1, FAM161A, ARL6, TTC8, RP1, RPGR
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	9	CRX, PRPF6, NRL, MAK, NR2E3, NEK2, ZNF408, TOPORS, ZNF513
cellular component assembly involved in morphogenesis (GO:0010927)	4.29	9	IFT172, BBS2, IFT140, RP1L1, FAM161A, ARL6, TTC8, RP1, RPGR
microtubule-based process (GO:0007017)	3.54	9	KIZ, IFT172, IFT140, RP1L1, NEK2, OFD1, RP1, BBS2, RPGR
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	9	CRX, NRL, PANK2, MAK, NR2E3, ZNF408, ZNF513, TOPORS, IMPDH1
aromatic compound biosynthetic process (GO:0019438)	1.7	9	CRX, NRL, PANK2, MAK, NR2E3, ZNF408, ZNF513, TOPORS, IMPDH1
cellular localization (GO:0051641)	2.32	9	CNGB1, IFT140, TULP1, PRPF31, TOPORS, MYO7A, BBS2, ARL6, RPGR
organic cyclic compound biosynthetic process (GO:1901362)	1.66	9	CRX, NRL, PANK2, MAK, NR2E3, ZNF408, ZNF513, TOPORS, IMPDH1
cytoskeleton organization (GO:0007010)	3.22	9	KIZ, FSCN2, IFT172, RP2, RP1L1, NEK2, OFD1, RP1, BBS2
heterocycle biosynthetic process (GO:0018130)	1.7	9	CRX, NRL, PANK2, MAK, NR2E3, ZNF408, ZNF513, TOPORS, IMPDH1
eye photoreceptor cell development (GO:0042462)	6.23	8	FSCN2, NRL, TULP1, TOPORS, NR2E3, CRB1, MYO7A, RP1
cellular protein metabolic process (GO:0044267)	1.63	8	RGR, KLHL7, MERTK, DHDDS, MAK, NEK2, RHO, TOPORS
cellular component morphogenesis (GO:0032989)	3.5	8	IFT172, MERTK, RP2, IFT140, PANK2, OFD1, BBS2, SEMA4A
cellular response to abiotic stimulus (GO:0071214)	4.15	8	CNGA1, CNGB1, PDE6B, SAG, PDE6A, RPE65, RHO, PDE6G
positive regulation of metabolic process (GO:0009893)	1.74	8	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2, PDE6G, GUCA1B
positive regulation of cellular metabolic process (GO:0031325)	1.81	8	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2, PDE6G, GUCA1B
regulation of RNA metabolic process (GO:0051252)	1.52	8	CRX, PRPF6, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)	4.97	8	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B
cellular protein modification process (GO:0006464)	1.79	8	KLHL7, DHDDS, MERTK, MAK, NEK2, RGR, RHO, TOPORS
movement of cell or subcellular component (GO:0006928)	2.61	8	MERTK, IFT140, OFD1, MYO7A, TTC8, CLRN1, SEMA4A, RPGR
establishment of protein localization (GO:0045184)	2.53	8	RP2, IFT140, ARL6, USH2A, MYO7A, TTC8, BBS2, RPGR
regulation of transcription, DNA-templated (GO:0006355)	1.56	8	CRX, PRPF6, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
macromolecule modification (GO:0043412)	1.73	8	KLHL7, DHDDS, MERTK, MAK, NEK2, RGR, RHO, TOPORS
protein modification process (GO:0036211)	1.79	8	RGR, KLHL7, MERTK, DHDDS, MAK, NEK2, RHO, TOPORS
regulation of nucleic acid-templated transcription (GO:1903506)	1.55	8	CRX, PRPF6, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
regulation of rhodopsin mediated signaling pathway (GO:0022400)	6.47	8	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B
regulation of RNA biosynthetic process (GO:2001141)	1.55	8	CRX, PRPF6, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
cellular lipid metabolic process (GO:0044255)	2.92	8	CYGB, DHDDS, RDH12, ABCA4, RPE65, RBP3, RHO, LRAT
regulation of localization (GO:0032879)	1.94	8	CYGB, BEST1, MERTK, SEMA4A, TULP1, LRAT, TTC8, BBS2
G-protein coupled receptor signaling pathway (GO:0007186)	2.64	8	CNGA1, CNGB1, RHO, PDE6B, SAG, PDE6A, PDE6G, RGR
lipid metabolic process (GO:0006629)	2.68	8	CYGB, RHO, DHDDS, ABCA4, RDH12, RPE65, RBP3, LRAT
cellular response to radiation (GO:0071478)	4.81	7	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	7	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2, GUCA1B
RNA biosynthetic process (GO:0032774)	1.84	7	CRX, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
positive regulation of biosynthetic process (GO:0009891)	2.29	7	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2, GUCA1B
rhodopsin mediated signaling pathway (GO:0016056)	7.24	7	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	7	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2, GUCA1B
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	7	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2, PDE6G
regulation of cellular component organization (GO:0051128)	2.01	7	MERTK, IFT140, TULP1, NEK2, TTC8, CLRN1, SEMA4A
macromolecular complex assembly (GO:0065003)	2.55	7	PRPF8, PRPF3, PRPF31, SNRNP200, PRPF6, HGSNAT, ARL6
macromolecular complex subunit organization (GO:0043933)	2.14	7	PRPF8, PRPF3, PRPF31, SNRNP200, PRPF6, HGSNAT, ARL6
cellular macromolecule biosynthetic process (GO:0034645)	1.66	7	CRX, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
macromolecule biosynthetic process (GO:0009059)	1.61	7	CRX, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
microtubule cytoskeleton organization (GO:0000226)	4.13	7	KIZ, IFT172, RP1L1, NEK2, OFD1, RP1, BBS2
nucleic acid-templated transcription (GO:0097659)	1.91	7	CRX, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
cilium assembly (GO:0042384)	4.77	7	FAM161A, IFT140, IFT172, ARL6, TTC8, BBS2, RPGR
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	7	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2, GUCA1B
protein transport (GO:0015031)	2.62	7	RP2, IFT140, ARL6, MYO7A, TTC8, BBS2, RPGR
cellular response to light stimulus (GO:0071482)	5.22	7	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO
RNA splicing (GO:0008380)	3.85	7	PRPF8, PRPF3, RP9, PRPF4, PRPF31, SNRNP200, PRPF6
RNA processing (GO:0006396)	3.01	7	PRPF8, PRPF3, RP9, PRPF4, PRPF31, SNRNP200, PRPF6
transcription, DNA-templated (GO:0006351)	1.91	7	CRX, NRL, MAK, NR2E3, ZNF408, TOPORS, ZNF513
phosphorylation (GO:0016310)	2.63	6	CERKL, MERTK, MAK, PANK2, NEK2, RHO
cellular macromolecular complex assembly (GO:0034622)	3.18	6	PRPF6, PRPF3, PRPF31, SNRNP200, PRPF8, ARL6
retinoid metabolic process (GO:0001523)	5.25	6	RBP3, RDH12, ABCA4, RPE65, LRAT, RHO
positive regulation of catalytic activity (GO:0043085)	2.4	6	RP2, TOPORS, NEK2, PDE6G, GUCA1B, RPGR
cellular macromolecule localization (GO:0070727)	3.1	6	CNGB1, IFT140, TULP1, ARL6, BBS2, TOPORS
animal organ development (GO:0048513)	2.53	6	IFT172, MERTK, IFT140, RPE65, BBS2, ARL6
positive regulation of molecular function (GO:0044093)	2.23	6	RP2, TOPORS, NEK2, PDE6G, GUCA1B, RPGR
diterpenoid metabolic process (GO:0016101)	5.17	6	RBP3, RDH12, ABCA4, RPE65, RHO, LRAT
neuron differentiation (GO:0030182)	4.17	6	IFT172, MYO7A, PROM1, ROM1, TTC8, USH2A
terpenoid metabolic process (GO:0006721)	5.07	6	RBP3, RDH12, ABCA4, RPE65, LRAT, RHO
isoprenoid metabolic process (GO:0006720)	4.89	6	RBP3, RDH12, ABCA4, RPE65, RHO, LRAT
cellular protein localization (GO:0034613)	3.11	6	CNGB1, IFT140, TULP1, ARL6, BBS2, TOPORS
RNA splicing, via transesterification reactions (GO:0000375)	4.25	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)	4.27	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
oxidation-reduction process (GO:0055114)	2.91	6	CYGB, RDH12, PANK2, RPE65, IDH3B, IMPDH1
mRNA metabolic process (GO:0016071)	3.33	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
organonitrogen compound metabolic process (GO:1901564)	2.32	6	PDE6B, PANK2, PDE6A, HGSNAT, IDH3B, IMPDH1
cell part morphogenesis (GO:0032990)	3.99	6	IFT172, SEMA4A, PANK2, OFD1, BBS2, IFT140
mRNA splicing, via spliceosome (GO:0000398)	4.27	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
protein localization to organelle (GO:0033365)	3.57	6	CNGB1, IFT140, TULP1, ARL6, BBS2, TOPORS
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	6	CRX, PRPF6, NRL, TOPORS, NR2E3, NEK2
organophosphate metabolic process (GO:0019637)	3.04	6	DHDDS, PDE6B, PANK2, PDE6A, IDH3B, IMPDH1
single-organism cellular localization (GO:1902580)	3.16	6	IFT140, TULP1, MYO7A, BBS2, ARL6, RPGR
mRNA processing (GO:0006397)	3.69	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
detection of light stimulus involved in sensory perception (GO:0050962)	6.84	5	TULP1, CNGB1, RPE65, EYS, BEST1
homeostatic process (GO:0042592)	2.61	5	TULP1, PDE6A, CNGB1, RPE65, PDE6B
membrane organization (GO:0061024)	3.04	5	ABCA4, TULP1, BBS2, CRB1, ARL6
positive regulation of gene expression (GO:0010628)	2.35	5	NRL, NR2E3, TOPORS, PRPF6, CRX
detection of stimulus involved in sensory perception (GO:0050906)	3.46	5	TULP1, CNGB1, RPE65, EYS, BEST1
intracellular signal transduction (GO:0035556)	2.39	5	TOPORS, RP1L1, RP1, MERTK, ARL6
multicellular organism development (GO:0007275)	2.54	5	NRL, CRX, SEMA4A, IFT172, MAK
ribonucleoprotein complex subunit organization (GO:0071826)	4.41	5	PRPF6, PRPF31, PRPF8, PRPF3, SNRNP200
ribonucleoprotein complex assembly (GO:0022618)	4.46	5	PRPF6, PRPF31, PRPF8, PRPF3, SNRNP200
nucleobase-containing small molecule metabolic process (GO:0055086)	3.59	5	PDE6A, PANK2, IDH3B, IMPDH1, PDE6B
negative regulation of molecular function (GO:0044092)	2.74	5	TTC8, SAG, PDE6G, NEK2, SLC7A14
biological adhesion (GO:0022610)	2.81	5	CDHR1, SEMA4A, PRPH2, ROM1, MERTK
positive regulation of nucleic acid-templated transcription (GO:1903508)	2.56	5	NRL, PRPF6, TOPORS, NR2E3, CRX
regulation of developmental process (GO:0050793)	2.1	5	IFT140, SEMA4A, PROM1, BBS2, CRX
ion transport (GO:0006811)	2.66	5	CNGA1, CNGB1, CA4, BEST1, SLC7A14
reproductive process (GO:0022414)	2.55	5	MERTK, MAK, PANK2, BBS2, NEK2
nucleotide metabolic process (GO:0009117)	3.73	5	IDH3B, PANK2, PDE6A, IMPDH1, PDE6B
positive regulation of transcription, DNA-templated (GO:0045893)	2.56	5	NRL, PRPF6, TOPORS, NR2E3, CRX
regulation of multicellular organismal process (GO:0051239)	1.87	5	CYGB, SEMA4A, PROM1, BBS2, CRX
establishment of localization in cell (GO:0051649)	2.47	5	ARL6, IFT140, BBS2, RPGR, MYO7A
cell adhesion (GO:0007155)	2.82	5	PRPH2, SEMA4A, CDHR1, MERTK, ROM1
transmembrane transport (GO:0055085)	2.72	5	CNGA1, ABCA4, CNGB1, BEST1, SLC7A14
detection of light stimulus involved in visual perception (GO:0050908)	6.84	5	TULP1, CNGB1, RPE65, EYS, BEST1
single organism reproductive process (GO:0044702)	2.73	5	MAK, BBS2, PANK2, MERTK, NEK2
cell projection morphogenesis (GO:0048858)	4.05	5	IFT140, SEMA4A, IFT172, BBS2, OFD1
carbohydrate derivative metabolic process (GO:1901135)	3.07	5	PDE6A, HGSNAT, PANK2, IMPDH1, PDE6B
positive regulation of RNA metabolic process (GO:0051254)	2.51	5	NRL, NR2E3, CRX, PRPF6, TOPORS
positive regulation of RNA biosynthetic process (GO:1902680)	2.54	5	NRL, PRPF6, TOPORS, NR2E3, CRX
single-organism membrane organization (GO:0044802)	3.19	5	ABCA4, TULP1, BBS2, CRB1, ARL6
nucleoside phosphate metabolic process (GO:0006753)	3.71	5	PDE6A, PANK2, IDH3B, IMPDH1, PDE6B
negative regulation of metabolic process (GO:0009892)	1.93	4	CYGB, NR2E3, BBS2, SLC7A14
regulation of transport (GO:0051049)	2.24	4	MERTK, TULP1, BEST1, LRAT
organ morphogenesis (GO:0009887)	3.55	4	IFT140, CRX, BBS2, MYO7A
carboxylic acid metabolic process (GO:0019752)	3.12	4	IDH3B, CYGB, PANK2, LRAT
protein localization to cilium (GO:0061512)	6.43	4	BBS2, TULP1, IFT140, ARL6
purine-containing compound metabolic process (GO:0072521)	4.0	4	PANK2, PDE6A, IMPDH1, PDE6B
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114)	3.79	4	PDE6G, ARL6, PDE6A, PDE6B
pattern specification process (GO:0007389)	3.79	4	IFT172, TTC8, IFT140, ARL6
spliceosomal snRNP assembly (GO:0000387)	6.12	4	PRPF6, PRPF31, PRPF8, PRPF3
negative regulation of catalytic activity (GO:0043086)	3.0	4	SAG, PDE6G, TTC8, SLC7A14
intracellular protein transport (GO:0006886)	3.2	4	IFT140, MYO7A, RPGR, ARL6
purine nucleoside metabolic process (GO:0042278)	4.32	4	PDE6A, PANK2, IMPDH1, PDE6B
ribonucleotide metabolic process (GO:0009259)	4.11	4	PDE6A, PANK2, IMPDH1, PDE6B
regulation of transcription from RNA polymerase II promoter (GO:0006357)	2.24	4	NRL, NR2E3, CRX, PRPF6
organic acid metabolic process (GO:0006082)	3.01	4	IDH3B, CYGB, PANK2, LRAT
positive regulation of cellular component organization (GO:0051130)	2.68	4	CLRN1, TULP1, MERTK, NEK2
protein phosphorylation (GO:0006468)	2.89	4	RHO, MAK, MERTK, NEK2
cilium morphogenesis (GO:0060271)	5.54	4	IFT172, BBS2, IFT140, OFD1
phototransduction, visible light (GO:0007603)	7.53	4	RHO, RP1, ABCA4, PDE6B
purine ribonucleotide metabolic process (GO:0009150)	4.16	4	PDE6A, PANK2, IMPDH1, PDE6B
regulation of cell differentiation (GO:0045595)	2.42	4	SEMA4A, PROM1, CRX, USH2A
nucleoside metabolic process (GO:0009116)	4.12	4	PANK2, PDE6A, IMPDH1, PDE6B
oxoacid metabolic process (GO:0043436)	3.12	4	IDH3B, CYGB, PANK2, LRAT
ribonucleoside metabolic process (GO:0009119)	4.21	4	PANK2, PDE6A, IMPDH1, PDE6B
purine ribonucleoside metabolic process (GO:0046128)	4.33	4	PDE6A, PANK2, IMPDH1, PDE6B
spliceosomal tri-snRNP complex assembly (GO:0000244)	7.24	4	PRPF6, PRPF31, PRPF8, PRPF3
regulation of hydrolase activity (GO:0051336)	2.53	4	RP2, TTC8, RPGR, SLC7A14
vesicle-mediated transport (GO:0016192)	2.72	4	RP2, TULP1, MERTK, MYO7A
intracellular transport (GO:0046907)	2.67	4	IFT140, MYO7A, RPGR, ARL6
Wnt signaling pathway (GO:0016055)	3.88	4	PDE6G, ARL6, PDE6A, PDE6B
ribose phosphate metabolic process (GO:0019693)	4.06	4	PDE6A, PANK2, IMPDH1, PDE6B
purine nucleotide metabolic process (GO:0006163)	4.09	4	PANK2, PDE6A, IMPDH1, PDE6B
glycosyl compound metabolic process (GO:1901657)	4.04	4	PDE6A, PANK2, IMPDH1, PDE6B
photoreceptor cell outer segment organization (GO:0035845)	7.65	4	RP1, IFT140, CNGB1, TOPORS
positive regulation of transcription from RNA polymerase II promoter (GO:0045944)	2.81	4	NRL, NR2E3, CRX, PRPF6
system development (GO:0048731)	2.92	4	SEMA4A, IFT140, CRX, ROM1
regulation of smoothened signaling pathway (GO:0008589)	5.62	3	IFT172, IFT140, ARL6
phagocytosis (GO:0006909)	5.54	3	TULP1, MERTK, MYO7A
anatomical structure homeostasis (GO:0060249)	4.25	3	TULP1, CNGB1, RPE65
purine ribonucleoside monophosphate metabolic process (GO:0009167)	4.7	3	PDE6A, IMPDH1, PDE6B
anion transport (GO:0006820)	3.71	3	CA4, BEST1, SLC7A14
ribonucleoside monophosphate metabolic process (GO:0009161)	4.62	3	PDE6A, IMPDH1, PDE6B
regulation of phosphate metabolic process (GO:0019220)	2.35	3	GUCA1B, PDE6G, SLC7A14
establishment of organelle localization (GO:0051656)	4.15	3	BBS2, ARL6, MYO7A
establishment of vesicle localization (GO:0051650)	4.91	3	BBS2, ARL6, MYO7A
hormone metabolic process (GO:0042445)	4.64	3	RPE65, RDH12, LRAT
single-organism biosynthetic process (GO:0044711)	2.8	3	PANK2, IMPDH1, DHDDS
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	3	BBS2, NR2E3, CYGB
determination of left/right symmetry (GO:0007368)	5.38	3	IFT172, IFT140, ARL6
epithelial cell differentiation (GO:0030855)	3.98	3	PROM1, USH2A, MYO7A
regulation of cell proliferation (GO:0042127)	2.41	3	IFT172, NR2E3, TOPORS
vitamin metabolic process (GO:0006766)	4.97	3	PANK2, RPE65, LRAT
positive regulation of transport (GO:0051050)	2.9	3	TULP1, MERTK, LRAT
sensory perception of sound (GO:0007605)	4.82	3	CLRN1, USH2A, MYO7A
negative regulation of cell death (GO:0060548)	2.95	3	CERKL, TOPORS, MERTK
GMP metabolic process (GO:0046037)	6.73	3	PDE6A, IMPDH1, PDE6B
transcription from RNA polymerase II promoter (GO:0006366)	3.38	3	NRL, CRX, NR2E3
organic anion transport (GO:0015711)	4.07	3	CA4, BEST1, SLC7A14
monocarboxylic acid metabolic process (GO:0032787)	3.57	3	CYGB, PANK2, LRAT
developmental process involved in reproduction (GO:0003006)	3.36	3	BBS2, PANK2, MERTK
lymphocyte activation (GO:0046649)	3.96	3	SEMA4A, MERTK, IMPDH1
protein localization to membrane (GO:0072657)	3.95	3	BBS2, TULP1, ARL6
eye photoreceptor cell differentiation (GO:0001754)	7.24	3	TTC8, PROM1, ROM1
non-canonical Wnt signaling pathway (GO:0035567)	4.79	3	PDE6G, PDE6A, PDE6B
single organism signaling (GO:0044700)	3.25	3	GUCA1B, MERTK, CRB1
cell motility (GO:0048870)	3.02	3	SEMA4A, CLRN1, MERTK
immune system process (GO:0002376)	2.29	3	SEMA4A, MERTK, IMPDH1
regulation of membrane potential (GO:0042391)	3.89	3	CNGA1, CNGB1, PANK2
leukocyte activation (GO:0045321)	3.76	3	SEMA4A, MERTK, IMPDH1
regulation of apoptotic process (GO:0042981)	2.5	3	CERKL, TOPORS, MERTK
photoreceptor cell differentiation (GO:0046530)	7.24	3	TTC8, PROM1, ROM1
positive regulation of transferase activity (GO:0051347)	3.31	3	TOPORS, PDE6G, NEK2
axoneme assembly (GO:0035082)	6.68	3	RP1, RP1L1, BBS2
regulation of GTPase activity (GO:0043087)	3.21	3	RP2, TTC8, RPGR
regulation of cell projection organization (GO:0031344)	3.38	3	SEMA4A, CLRN1, IFT140
pigment granule localization (GO:0051875)	6.55	3	BBS2, ARL6, MYO7A
guanosine-containing compound metabolic process (GO:1901068)	5.9	3	PDE6A, IMPDH1, PDE6B
inorganic ion transmembrane transport (GO:0098660)	3.38	3	CNGA1, CNGB1, BEST1
sensory perception of mechanical stimulus (GO:0050954)	4.79	3	CLRN1, USH2A, MYO7A
tissue development (GO:0009888)	3.27	3	IFT172, TTC8, EYS
spindle organization (GO:0007051)	5.33	3	KIZ, OFD1, NEK2
cell activation (GO:0001775)	3.47	3	SEMA4A, MERTK, IMPDH1
primary alcohol metabolic process (GO:0034308)	5.9	3	RPE65, RDH12, LRAT
organophosphate biosynthetic process (GO:0090407)	3.67	3	PANK2, IMPDH1, DHDDS
Wnt signaling pathway, calcium modulating pathway (GO:0007223)	6.12	3	PDE6G, PDE6A, PDE6B
endocytosis (GO:0006897)	3.69	3	TULP1, MERTK, MYO7A
microtubule bundle formation (GO:0001578)	5.9	3	RP1, RP1L1, BBS2
response to stress (GO:0006950)	1.8	3	CYGB, TOPORS, IMPDH1
regulation of transferase activity (GO:0051338)	2.88	3	TOPORS, PDE6G, NEK2
regulation of cell motility (GO:2000145)	3.16	3	SEMA4A, CYGB, BBS2
organic hydroxy compound metabolic process (GO:1901615)	3.84	3	RPE65, RDH12, LRAT
regulation of organelle organization (GO:0033043)	2.72	3	IFT140, TTC8, NEK2
retina layer formation (GO:0010842)	6.64	3	ARL6, TOPORS, PROM1
signaling (GO:0023052)	3.25	3	GUCA1B, MERTK, CRB1
retina morphogenesis in camera-type eye (GO:0060042)	7.43	3	PROM1, RPE65, ROM1
specification of symmetry (GO:0009799)	5.36	3	IFT172, IFT140, ARL6
nucleoside monophosphate metabolic process (GO:0009123)	4.54	3	PDE6A, IMPDH1, PDE6B
retinol metabolic process (GO:0042572)	6.29	3	RPE65, RDH12, LRAT
purine nucleoside monophosphate metabolic process (GO:0009126)	4.69	3	PDE6A, IMPDH1, PDE6B
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	CRX, PROM1, BBS2
negative regulation of multicellular organismal process (GO:0051241)	2.84	3	SEMA4A, BBS2, CYGB
proteolysis (GO:0006508)	2.73	3	IFT172, TOPORS, RBP3
regulation of locomotion (GO:0040012)	3.12	3	SEMA4A, CYGB, BBS2
camera-type eye photoreceptor cell differentiation (GO:0060219)	7.65	3	TTC8, PROM1, ROM1
tissue homeostasis (GO:0001894)	4.78	3	TULP1, CNGB1, RPE65
retina homeostasis (GO:0001895)	6.07	3	TULP1, CNGB1, RPE65
positive regulation of developmental process (GO:0051094)	2.77	3	CRX, PROM1, BBS2
establishment of pigment granule localization (GO:0051905)	6.59	3	BBS2, ARL6, MYO7A
pigment granule transport (GO:0051904)	6.64	3	BBS2, ARL6, MYO7A
cell cycle process (GO:0022402)	2.75	3	KIZ, OFD1, NEK2
fat cell differentiation (GO:0045444)	5.02	3	BBS2, TTC8, ARL6
regulation of cell death (GO:0010941)	2.43	3	CERKL, TOPORS, MERTK
regulation of programmed cell death (GO:0043067)	2.49	3	CERKL, TOPORS, MERTK
negative regulation of apoptotic process (GO:0043066)	3.04	3	CERKL, TOPORS, MERTK
negative regulation of programmed cell death (GO:0043069)	3.02	3	CERKL, TOPORS, MERTK
regulation of hormone levels (GO:0010817)	3.56	3	RPE65, RDH12, LRAT
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	GUCA1B, PDE6G, SLC7A14
ion transmembrane transport (GO:0034220)	3.08	3	CNGA1, CNGB1, BEST1
vesicle localization (GO:0051648)	4.85	3	BBS2, ARL6, MYO7A
cell-cell signaling (GO:0007267)	3.35	3	GUCA1B, MERTK, CRB1
cell communication (GO:0007154)	3.04	3	GUCA1B, MERTK, CRB1
cellular hormone metabolic process (GO:0034754)	5.09	3	RPE65, LRAT, RDH12
organelle localization (GO:0051640)	3.94	3	BBS2, ARL6, MYO7A
locomotion (GO:0040011)	2.91	3	SEMA4A, CLRN1, MERTK
regulation of rhodopsin gene expression (GO:0007468)	8.63	3	NRL, NR2E3, RPE65
regulation of cellular component movement (GO:0051270)	3.08	3	SEMA4A, CYGB, BBS2
microtubule-based movement (GO:0007018)	4.39	3	OFD1, IFT140, RPGR
alcohol metabolic process (GO:0006066)	4.2	3	RPE65, RDH12, LRAT
regulation of cellular component biogenesis (GO:0044087)	3.08	3	IFT140, CLRN1, TTC8
regulation of multicellular organismal development (GO:2000026)	2.31	3	SEMA4A, PROM1, CRX
determination of bilateral symmetry (GO:0009855)	5.37	3	IFT172, IFT140, ARL6
retinal rod cell development (GO:0046548)	7.33	3	NRL, RP1, TOPORS
single-organism intracellular transport (GO:1902582)	3.59	3	IFT140, ARL6, RPGR
vitamin A metabolic process (GO:0006776)	7.65	2	RPE65, LRAT
fat-soluble vitamin metabolic process (GO:0006775)	6.26	2	RPE65, LRAT
developmental growth (GO:0048589)	4.05	2	EYS, TTC8
G2/M transition of mitotic cell cycle (GO:0000086)	4.84	2	OFD1, NEK2
negative regulation of response to stimulus (GO:0048585)	2.52	2	SEMA4A, BBS2
positive regulation of response to stimulus (GO:0048584)	2.18	2	IFT172, PDE6G
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	NR2E3, SLC7A14
plasma membrane organization (GO:0007009)	4.8	2	BBS2, CRB1
nucleotide biosynthetic process (GO:0009165)	4.49	2	PANK2, IMPDH1
nucleoside biosynthetic process (GO:0009163)	4.97	2	PANK2, IMPDH1
enzyme linked receptor protein signaling pathway (GO:0007167)	3.24	2	GUCA1B, RPE65
inorganic ion homeostasis (GO:0098771)	3.43	2	PDE6A, PDE6B
purine ribonucleoside biosynthetic process (GO:0046129)	5.25	2	PANK2, IMPDH1
rhythmic process (GO:0048511)	4.02	2	CRX, RPE65
positive regulation of signal transduction (GO:0009967)	2.5	2	IFT172, PDE6G
regulation of cytoskeleton organization (GO:0051493)	3.72	2	TTC8, NEK2
peptidyl-amino acid modification (GO:0018193)	2.98	2	TOPORS, MERTK
regulation of neuron differentiation (GO:0045664)	3.39	2	SEMA4A, CRX
protein localization to ciliary membrane (GO:1903441)	7.94	2	BBS2, TULP1
cellular homeostasis (GO:0019725)	3.23	2	PDE6A, PDE6B
sensory perception of smell (GO:0007608)	3.61	2	CNGB1, TTC8
centrosome organization (GO:0051297)	5.38	2	OFD1, NEK2
sensory perception of chemical stimulus (GO:0007606)	3.49	2	CNGB1, TTC8
spermatogenesis (GO:0007283)	3.7	2	MAK, MERTK
establishment of localization by movement along microtubule (GO:0010970)	5.14	2	IFT140, RPGR
regionalization (GO:0003002)	4.24	2	IFT172, IFT140
purine nucleoside biosynthetic process (GO:0042451)	5.25	2	PANK2, IMPDH1
response to organic substance (GO:0010033)	2.2	2	BBS2, PRPF8
ribonucleoside biosynthetic process (GO:0042455)	5.06	2	PANK2, IMPDH1
protein modification by small protein conjugation or removal (GO:0070647)	2.95	2	TOPORS, KLHL7
protein complex localization (GO:0031503)	5.62	2	IFT140, RPGR
organonitrogen compound biosynthetic process (GO:1901566)	2.85	2	PANK2, IMPDH1
axis specification (GO:0009798)	5.42	2	IFT172, TTC8
regulation of cell projection assembly (GO:0060491)	4.66	2	IFT140, CLRN1
chemical homeostasis (GO:0048878)	2.97	2	PDE6A, PDE6B
protein ubiquitination (GO:0016567)	3.28	2	TOPORS, KLHL7
purine nucleotide biosynthetic process (GO:0006164)	4.87	2	PANK2, IMPDH1
calcium ion homeostasis (GO:0055074)	3.97	2	PDE6A, PDE6B
regulation of cell morphogenesis (GO:0022604)	3.4	2	SEMA4A, IFT140
positive regulation of GTPase activity (GO:0043547)	3.28	2	RP2, RPGR
bicarbonate transport (GO:0015701)	5.97	2	CA4, BEST1
negative regulation of biosynthetic process (GO:0009890)	2.47	2	CYGB, NR2E3
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	2	SEMA4A, IFT140
negative regulation of gene expression (GO:0010629)	2.48	2	BBS2, NR2E3
protein localization to nonmotile primary cilium (GO:0097499)	7.43	2	ARL6, TULP1
inner ear receptor cell differentiation (GO:0060113)	7.02	2	USH2A, MYO7A
mitotic nuclear division (GO:0007067)	4.05	2	OFD1, NEK2
spindle assembly (GO:0051225)	5.57	2	OFD1, NEK2
hair cell differentiation (GO:0035315)	7.02	2	USH2A, MYO7A
organic substance catabolic process (GO:1901575)	2.45	2	HGSNAT, TOPORS
cofactor metabolic process (GO:0051186)	3.91	2	IDH3B, PANK2
negative regulation of hydrolase activity (GO:0051346)	3.74	2	TTC8, SLC7A14
positive regulation of hydrolase activity (GO:0051345)	2.91	2	RP2, RPGR
potassium ion transport (GO:0006813)	4.68	2	CNGA1, CNGB1
negative regulation of cellular component organization (GO:0051129)	3.35	2	SEMA4A, NEK2
protein transport along microtubule (GO:0098840)	6.43	2	IFT140, RPGR
inorganic cation transmembrane transport (GO:0098662)	3.55	2	CNGA1, CNGB1
negative regulation of developmental growth (GO:0048640)	5.25	2	SEMA4A, BBS2
cell migration (GO:0016477)	3.12	2	SEMA4A, MERTK
single organism cell adhesion (GO:0098602)	3.63	2	SEMA4A, MERTK
circadian rhythm (GO:0007623)	4.79	2	CRX, RPE65
positive regulation of rhodopsin gene expression (GO:0045872)	9.04	2	NRL, NR2E3
divalent inorganic cation homeostasis (GO:0072507)	3.9	2	PDE6A, PDE6B
cell-cell adhesion (GO:0098609)	3.34	2	SEMA4A, CDHR1
cation transport (GO:0006812)	3.11	2	CNGA1, CNGB1
equilibrioception (GO:0050957)	7.94	2	CLRN1, MYO7A
purine ribonucleotide biosynthetic process (GO:0009152)	4.92	2	PANK2, IMPDH1
ribonucleotide biosynthetic process (GO:0009260)	4.82	2	PANK2, IMPDH1
leukocyte differentiation (GO:0002521)	4.13	2	SEMA4A, MERTK
secretion (GO:0046903)	3.38	2	GUCA1B, MERTK
brain development (GO:0007420)	4.24	2	IFT172, ARL6
potassium ion transmembrane transport (GO:0071805)	4.79	2	CNGA1, CNGB1
ribose phosphate biosynthetic process (GO:0046390)	4.79	2	PANK2, IMPDH1
regulation of nervous system development (GO:0051960)	3.1	2	SEMA4A, CRX
nucleoside phosphate biosynthetic process (GO:1901293)	4.47	2	PANK2, IMPDH1
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	CYGB, NR2E3
regulation of developmental growth (GO:0048638)	4.04	2	SEMA4A, BBS2
negative regulation of response to external stimulus (GO:0032102)	4.18	2	SEMA4A, BBS2
coenzyme metabolic process (GO:0006732)	4.14	2	PANK2, IDH3B
nuclear division (GO:0000280)	3.85	2	OFD1, NEK2
ion homeostasis (GO:0050801)	3.42	2	PDE6A, PDE6B
metal ion homeostasis (GO:0055065)	3.61	2	PDE6A, PDE6B
melanosome transport (GO:0032402)	6.68	2	BBS2, ARL6
intraciliary transport (GO:0042073)	6.43	2	IFT140, RPGR
positive regulation of signaling (GO:0023056)	2.41	2	IFT172, PDE6G
regulation of microtubule-based process (GO:0032886)	4.79	2	BBS2, NEK2
positive regulation of cell communication (GO:0010647)	2.41	2	IFT172, PDE6G
protein localization to cell periphery (GO:1990778)	4.91	2	BBS2, TULP1
protein autophosphorylation (GO:0046777)	4.46	2	MAK, NEK2
positive regulation of phagocytosis (GO:0050766)	5.9	2	TULP1, MERTK
regulation of neurogenesis (GO:0050767)	3.21	2	SEMA4A, CRX
regulation of phagocytosis (GO:0050764)	5.49	2	TULP1, MERTK
cellular divalent inorganic cation homeostasis (GO:0072503)	3.96	2	PDE6A, PDE6B
cellular potassium ion transport (GO:0071804)	4.79	2	CNGA1, CNGB1
protein modification by small protein conjugation (GO:0032446)	3.1	2	TOPORS, KLHL7
catabolic process (GO:0009056)	2.38	2	HGSNAT, TOPORS
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	2	GUCA1B, PDE6G
regulation of protein metabolic process (GO:0051246)	1.93	2	TOPORS, PDE6G
positive regulation of protein metabolic process (GO:0051247)	2.43	2	TOPORS, PDE6G
regulation of cell development (GO:0060284)	3.01	2	SEMA4A, CRX
cytoskeleton-dependent intracellular transport (GO:0030705)	4.96	2	IFT140, RPGR
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	2	TOPORS, PDE6G
regulation of protein modification process (GO:0031399)	2.32	2	TOPORS, PDE6G
microtubule cytoskeleton organization involved in mitosis (GO:1902850)	6.17	2	OFD1, NEK2
establishment of melanosome localization (GO:0032401)	6.64	2	BBS2, ARL6
melanosome localization (GO:0032400)	6.59	2	BBS2, ARL6
monovalent inorganic cation transport (GO:0015672)	3.74	2	CNGA1, CNGB1
negative regulation of cell proliferation (GO:0008285)	3.26	2	IFT172, NR2E3
microtubule organizing center organization (GO:0031023)	5.26	2	OFD1, NEK2
multicellular organismal reproductive process (GO:0048609)	3.35	2	MAK, MERTK
actin filament organization (GO:0007015)	4.54	2	FSCN2, CLRN1
cellular metal ion homeostasis (GO:0006875)	3.75	2	PDE6A, PDE6B
cellular calcium ion homeostasis (GO:0006874)	4.01	2	PDE6A, PDE6B
epithelium development (GO:0060429)	4.57	2	IFT172, TTC8
negative regulation of locomotion (GO:0040013)	4.22	2	SEMA4A, CYGB
cellular ion homeostasis (GO:0006873)	3.57	2	PDE6A, PDE6B
regulation of vesicle-mediated transport (GO:0060627)	3.63	2	TULP1, MERTK
positive regulation of cell differentiation (GO:0045597)	3.01	2	CRX, PROM1
negative regulation of cell differentiation (GO:0045596)	3.33	2	SEMA4A, USH2A
metal ion transport (GO:0030001)	3.36	2	CNGA1, CNGB1
cellular cation homeostasis (GO:0030003)	3.6	2	PDE6A, PDE6B
male gamete generation (GO:0048232)	3.7	2	MAK, MERTK
cation homeostasis (GO:0055080)	3.46	2	PDE6A, PDE6B
cellular chemical homeostasis (GO:0055082)	3.4	2	PDE6A, PDE6B
negative regulation of developmental process (GO:0051093)	3.17	2	SEMA4A, BBS2
retinal cone cell development (GO:0046549)	7.65	2	RP1, TOPORS
regulation of cellular protein metabolic process (GO:0032268)	1.99	2	TOPORS, PDE6G
carbohydrate derivative biosynthetic process (GO:1901137)	3.73	2	PANK2, IMPDH1
mechanoreceptor differentiation (GO:0042490)	6.78	2	USH2A, MYO7A
regulation of cytosolic calcium ion concentration (GO:0051480)	4.41	2	PDE6A, PDE6B
lymphocyte differentiation (GO:0030098)	4.49	2	SEMA4A, MERTK
positive regulation of protein modification process (GO:0031401)	2.7	2	TOPORS, PDE6G
negative regulation of growth (GO:0045926)	4.24	2	SEMA4A, BBS2
cell cycle G2/M phase transition (GO:0044839)	4.82	2	OFD1, NEK2
regulation of cell activation (GO:0050865)	3.53	2	CYGB, MERTK
cognition (GO:0050890)	4.2	2	RP9, TTC8
negative regulation of cell activation (GO:0050866)	4.67	2	CYGB, MERTK
mitotic cell cycle process (GO:1903047)	3.12	2	OFD1, NEK2
cell cycle phase transition (GO:0044770)	4.24	2	OFD1, NEK2
mitotic cell cycle phase transition (GO:0044772)	4.27	2	OFD1, NEK2
mitotic spindle assembly (GO:0090307)	6.17	2	OFD1, NEK2
positive regulation of phosphate metabolic process (GO:0045937)	2.78	2	GUCA1B, PDE6G
purine-containing compound biosynthetic process (GO:0072522)	4.79	2	PANK2, IMPDH1
gamete generation (GO:0007276)	3.61	2	MAK, MERTK
growth (GO:0040007)	3.8	2	EYS, TTC8
protein complex subunit organization (GO:0071822)	2.6	2	HGSNAT, ARL6
regulation of growth (GO:0040008)	3.26	2	SEMA4A, BBS2
RNA localization (GO:0006403)	6.68	2	PRPF31, PRPF6
embryonic morphogenesis (GO:0048598)	3.72	2	IFT172, MYO7A
regulation of cell migration (GO:0030334)	3.23	2	SEMA4A, CYGB
actin filament-based process (GO:0030029)	3.94	2	FSCN2, MYO7A
protein complex assembly (GO:0006461)	2.78	2	HGSNAT, ARL6
protein-chromophore linkage (GO:0018298)	7.02	2	RHO, RGR
cellular process involved in reproduction in multicellular organism (GO:0022412)	4.3	2	BBS2, PANK2
response to chemical (GO:0042221)	1.98	2	BBS2, PRPF8
tube development (GO:0035295)	4.41	2	IFT172, TTC8
regulation of endocytosis (GO:0030100)	4.42	2	TULP1, MERTK
macromolecule catabolic process (GO:0009057)	3.0	2	HGSNAT, TOPORS
cell morphogenesis (GO:0000902)	4.35	2	RP2, MERTK
heart development (GO:0007507)	4.24	2	IFT172, IFT140
negative regulation of cellular component movement (GO:0051271)	4.22	2	SEMA4A, CYGB
nervous system development (GO:0007399)	3.53	2	SEMA4A, CRX
regulation of cell cycle (GO:0051726)	2.93	2	MAK, NEK2
epidermal cell differentiation (GO:0009913)	5.13	2	USH2A, MYO7A
establishment of protein localization to membrane (GO:0090150)	4.14	2	BBS2, ARL6
organelle fission (GO:0048285)	3.79	2	OFD1, NEK2
positive regulation of endocytosis (GO:0045807)	4.98	2	TULP1, MERTK
cation transmembrane transport (GO:0098655)	3.43	2	CNGA1, CNGB1
glycosyl compound biosynthetic process (GO:1901659)	4.95	2	PANK2, IMPDH1

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
developmental process (GO:0032502)	-	1.36	0.0	CRX, PDE6A, MYO7A, TOPORS, SNRNP200, PRPH2, BBS2, FSCN2, FAM161A, PDE6B, PROM1, PANK2, CRB1, OFD1, RPE65, ROM1, ARL6, EYS, RPGR, MERTK, NRL, TULP1, SEMA4A, RP1L1, MAK, RP1, ZNF513, IFT172, RP2, IFT140, NR2E3, NEK2, CA4, USH2A, RHO, TTC8
detection of light stimulus involved in sensory perception (GO:0050962)	-	6.84	0.0	CNGA1, CNGB1, EYS, TULP1, RPE65, BEST1
cellular component assembly (GO:0022607)	-	2.14	0.039	FSCN2, CNGB1, PRPF6, MYO7A, IFT140, FAM161A, NEK2, ARL6, OFD1, PRPF31, HGSNAT, TTC8, SNRNP200, RP1, IFT172, BBS2, RPGR
cellular response to light stimulus (GO:0071482)	-	5.22	0.0	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, RP1, GUCA1B
cell projection organization (GO:0030030)	-	3.14	0.0	FAM161A, SEMA4A, RP1L1, IFT140, TULP1, IFT172, ARL6, OFD1, TTC8, MYO7A, RP1, CLRN1, BBS2, RPGR
cell projection assembly (GO:0030031)	-	4.19	0.0	IFT172, BBS2, IFT140, FAM161A, ARL6, OFD1, TTC8, RP1, RPGR
cell development (GO:0048468)	-	3.28	0.003	FSCN2, RP1L1, NRL, PANK2, TOPORS, TULP1, CRB1, MYO7A, NR2E3, RP1, RPGR
cellular component assembly involved in morphogenesis (GO:0010927)	-	4.29	0.0	IFT172, BBS2, IFT140, FAM161A, ARL6, OFD1, TTC8, RP1, RPGR
regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)	-	4.97	0.0	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B
multicellular organismal process (GO:0032501)	-	1.45	0.0	CRX, IMPG2, RDH12, SAG, CDHR1, RGR, PRPH2, BBS2, ABCA4, FSCN2, FAM161A, PDE6B, RP9, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, MAK, RPGR, BEST1, CNGB1, RBP3, MERTK, NRL, TULP1, RP1L1, MYO7A, RHO, RP1, GUCA1B, ZNF513, CNGA1, IFT172, RP2, NR2E3, C2orf71, PDE6G, USH2A, LRAT, TTC8, PROM1
response to light stimulus (GO:0009416)	-	4.08	0.0	CNGA1, BEST1, CNGB1, RBP3, PDE6B, EYS, TULP1, PROM1, PDE6A, CRX, RDH12, RHO, RPE65, RGR, GUCA1B, PDE6G, RP1, LRAT, SAG, NR2E3, ABCA4
retina development in camera-type eye (GO:0060041)	-	5.51	0.0	CNGB1, MERTK, PDE6B, PDE6A, IFT140, TULP1, CRX, ZNF513, RHO, NR2E3, PRPH2, RPGR
regulation of rhodopsin mediated signaling pathway (GO:0022400)	-	6.47	0.0	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B
detection of light stimulus involved in visual perception (GO:0050908)	-	6.84	0.0	CNGA1, CNGB1, EYS, TULP1, RPE65, BEST1
isoprenoid metabolic process (GO:0006720)	-	4.89	0.004	RBP3, RDH12, ABCA4, RPE65, LRAT, RHO
retinoid metabolic process (GO:0001523)	-	5.25	0.0	CNGB1, RHO, RDH12, ABCA4, RPE65, RBP3, LRAT
single-organism process (GO:0044699)	-	0.48	0.004	IMPG2, CRX, PDE6A, RGR, RDH12, SAG, CYGB, CDHR1, CRB1, SNRNP200, PRPH2, BBS2, ABCA4, FSCN2, FAM161A, PDE6B, PROM1, PANK2, PRCD, NRL, OFD1, RPE65, ZNF513, ROM1, PDE6G, ARL6, CLRN1, TOPORS, USH2A, KIZ, CNGB1, RBP3, MERTK, SLC7A14, EYS, RP1L1, SEMA4A, TULP1, MYO7A, MAK, RHO, RP1, IDH3B, HGSNAT, IMPDH1, BEST1, CNGA1, IFT172, DHDDS, RP2, IFT140, NR2E3, NEK2, C2orf71, CA4, RPGR, LRAT, GUCA1B, TTC8, RP9
eye photoreceptor cell development (GO:0042462)	-	6.23	0.0	FSCN2, CRX, MYO7A, NRL, NR2E3, TOPORS, TULP1, CNGB1, CRB1, RHO, RP1, RPGR
tissue development (GO:0009888)	-	3.27	0.0	CRX, PDE6B, MERTK, PDE6A, IFT140, TULP1, IFT172, RHO, NR2E3, TTC8, PRPH2, EYS, ZNF513
cellular response to radiation (GO:0071478)	-	4.81	0.0	CNGA1, CNGB1, RHO, PDE6B, SAG, PDE6A, PDE6G, RBP3, RP1, GUCA1B
axoneme assembly (GO:0035082)	-	6.68	0.037	RP1, BBS2, OFD1
cellular developmental process (GO:0048869)	-	1.82	0.002	MYO7A, TOPORS, SNRNP200, RP1, FSCN2, PROM1, PANK2, CRB1, OFD1, ROM1, ARL6, MAK, USH2A, MERTK, NRL, TULP1, SEMA4A, RP1L1, BBS2, IFT172, RP2, NR2E3, RPGR, TTC8
response to radiation (GO:0009314)	-	3.69	0.0	CNGA1, BEST1, CNGB1, RGR, RDH12, RBP3, TULP1, SAG, PDE6A, CRX, NR2E3, PROM1, RPE65, RHO, GUCA1B, PDE6B, PDE6G, RP1, LRAT, EYS, ABCA4
detection of light stimulus (GO:0009583)	-	5.67	0.0	CNGA1, BEST1, CNGB1, RGR, PDE6B, EYS, PDE6A, SAG, TULP1, CRX, RDH12, RBP3, RPE65, RHO, GUCA1B, PDE6G, RP1, LRAT, ABCA4, NR2E3
neurological system process (GO:0050877)	-	2.64	0.0	CRX, PRPF8, IMPG2, RDH12, SAG, RGR, PRPH2, BBS2, FSCN2, FAM161A, RP9, PDE6A, RBP3, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, USH2A, BEST1, CNGB1, RHO, PDE6B, NRL, TULP1, RP1L1, MYO7A, RP1, GUCA1B, ZNF513, CNGA1, IFT172, RP2, NR2E3, NEK2, C2orf71, PDE6G, RPGR, LRAT, TTC8
diterpenoid metabolic process (GO:0016101)	-	5.17	0.001	CNGB1, RHO, RDH12, ABCA4, RPE65, RBP3, LRAT
cellular response to abiotic stimulus (GO:0071214)	-	4.15	0.0	CNGA1, CNGB1, RHO, PDE6B, SAG, PDE6A, RPE65, RBP3, GUCA1B, PDE6G, RP1, ABCA4
anatomical structure formation involved in morphogenesis (GO:0048646)	-	3.01	0.011	FAM161A, SEMA4A, IFT140, IFT172, ARL6, OFD1, PROM1, TOPORS, TTC8, RP1, BBS2, RPGR
neuron development (GO:0048666)	-	4.8	0.0	FSCN2, CRX, RP1L1, MYO7A, NRL, NR2E3, TOPORS, TULP1, CNGB1, CRB1, RHO, RP1, RPGR
detection of external stimulus (GO:0009581)	-	4.98	0.0	CRX, RGR, RDH12, SAG, BEST1, PROM1, RPE65, GUCA1B, ABCA4, USH2A, CNGB1, RBP3, PDE6B, TULP1, EYS, PDE6A, RHO, RP1, CNGA1, NR2E3, PDE6G, LRAT
detection of abiotic stimulus (GO:0009582)	-	4.96	0.0	CRX, RGR, RDH12, SAG, BEST1, PROM1, RPE65, GUCA1B, ABCA4, USH2A, CNGB1, RBP3, PDE6B, TULP1, EYS, PDE6A, RHO, RP1, CNGA1, NR2E3, PDE6G, LRAT
cilium assembly (GO:0042384)	-	4.77	0.0	FAM161A, IFT140, IFT172, ARL6, TTC8, BBS2, RPGR
detection of visible light (GO:0009584)	-	6.23	0.0	CNGA1, BEST1, CNGB1, PDE6B, RDH12, EYS, PDE6A, SAG, TULP1, RHO, RPE65, RBP3, GUCA1B, PDE6G, RP1, LRAT, ABCA4
positive regulation of rhodopsin gene expression (GO:0045872)	-	9.04	0.013	NRL, NR2E3
response to abiotic stimulus (GO:0009628)	-	2.8	0.0	CNGA1, BEST1, CNGB1, PDE6B, RDH12, EYS, TULP1, SAG, PDE6A, RBP3, RHO, RPE65, RGR, GUCA1B, PDE6G, RP1, LRAT, ABCA4, NR2E3
terpenoid metabolic process (GO:0006721)	-	5.07	0.001	RBP3, RDH12, ABCA4, RPE65, LRAT, RHO
retinal rod cell development (GO:0046548)	-	7.33	0.001	NRL, RP1, TOPORS, CRX
GMP metabolic process (GO:0046037)	-	6.73	0.003	PDE6A, IMPDH1, PDE6B
visual perception (GO:0007601)	-	4.41	0.0	CRX, IMPG2, RDH12, SAG, RGR, PRPH2, BBS2, FSCN2, FAM161A, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, USH2A, BEST1, CNGB1, RBP3, PDE6B, NRL, TULP1, RP1L1, RHO, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, RPGR, LRAT, MYO7A
sensory perception (GO:0007600)	-	2.93	0.0	CRX, PRPF8, IMPG2, RDH12, SAG, RGR, PRPH2, BBS2, FSCN2, FAM161A, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, RPGR, BEST1, CNGB1, RBP3, PDE6B, NRL, TULP1, RP1L1, MYO7A, RHO, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, USH2A, LRAT, TTC8
sensory perception of light stimulus (GO:0050953)	-	4.4	0.0	CRX, IMPG2, RDH12, SAG, RGR, PRPH2, BBS2, FSCN2, FAM161A, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, USH2A, BEST1, CNGB1, RBP3, PDE6B, NRL, TULP1, RP1L1, RHO, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, RPGR, LRAT, MYO7A
phototransduction (GO:0007602)	-	5.99	0.0	CNGA1, CNGB1, RGR, PDE6B, RBP3, TULP1, SAG, PDE6A, CRX, RDH12, NR2E3, RPE65, RHO, GUCA1B, PDE6G, RP1, LRAT, ABCA4
single-organism developmental process (GO:0044767)	-	1.49	0.048	CRX, MYO7A, TOPORS, SNRNP200, BBS2, FSCN2, FAM161A, PROM1, PANK2, CRB1, OFD1, RPE65, ROM1, ARL6, SEMA4A, RPGR, MERTK, NRL, TULP1, EYS, RP1L1, MAK, RP1, IFT172, RP2, IFT140, NR2E3, NEK2, USH2A, TTC8
photoreceptor cell development (GO:0042461)	-	6.17	0.0	FSCN2, CRX, RP1L1, MYO7A, NRL, NR2E3, TOPORS, TULP1, CNGB1, CRB1, RHO, RP1, RPGR
phototransduction, visible light (GO:0007603)	-	7.53	0.0	CNGA1, CNGB1, RBP3, PDE6B, SAG, PDE6A, RDH12, RPE65, RHO, GUCA1B, PDE6G, RP1, LRAT, ABCA4
camera-type eye photoreceptor cell differentiation (GO:0060219)	-	7.65	0.002	TTC8, PROM1, ROM1
eye photoreceptor cell differentiation (GO:0001754)	-	7.24	0.038	TTC8, PROM1, ROM1
organelle assembly (GO:0070925)	-	3.75	0.001	FAM161A, IFT140, IFT172, NEK2, ARL6, MYO7A, TTC8, BBS2, RPGR
system process (GO:0003008)	-	2.3	0.0	CRX, IMPG2, RDH12, SAG, RGR, PRPH2, BBS2, FSCN2, FAM161A, RP9, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, ABCA4, USH2A, BEST1, CNGB1, RBP3, PDE6B, NRL, TULP1, RP1L1, MYO7A, RHO, RP1, GUCA1B, ZNF513, CNGA1, RP2, NR2E3, C2orf71, PDE6G, RPGR, LRAT, TTC8
regulation of rhodopsin gene expression (GO:0007468)	-	8.63	0.0	NRL, NR2E3, RPE65
detection of stimulus (GO:0051606)	-	3.22	0.0	CRX, RGR, RDH12, SAG, BEST1, PROM1, RPE65, GUCA1B, ABCA4, USH2A, CNGB1, RBP3, PDE6B, TULP1, EYS, PDE6A, RHO, RP1, CNGA1, NR2E3, PDE6G, LRAT
response to external stimulus (GO:0009605)	-	2.55	0.0	CNGA1, BEST1, CNGB1, RGR, PDE6B, PDE6A, SAG, TULP1, RBP3, RDH12, NR2E3, RPE65, RHO, GUCA1B, PDE6G, RP1, LRAT, EYS, ABCA4
single-multicellular organism process (GO:0044707)	-	1.78	0.0	CRX, IMPG2, RDH12, SAG, CDHR1, RGR, PRPH2, BBS2, ABCA4, FSCN2, FAM161A, PDE6B, RP9, PDE6A, PRCD, RPE65, ROM1, ARL6, CLRN1, MAK, RPGR, BEST1, CNGB1, RBP3, MERTK, NRL, TULP1, RP1L1, MYO7A, RHO, RP1, GUCA1B, ZNF513, CNGA1, IFT172, RP2, NR2E3, C2orf71, PDE6G, USH2A, LRAT, TTC8, PROM1
rhodopsin mediated signaling pathway (GO:0016056)	-	7.24	0.0	CNGA1, CNGB1, PDE6B, SAG, PDE6A, PDE6G, RHO, GUCA1B
anatomical structure development (GO:0048856)	-	1.58	0.001	CRX, TOPORS, MYO7A, PRPH2, RP1, FSCN2, PDE6B, PANK2, CRB1, ROM1, RPGR, MERTK, NRL, TULP1, EYS, RP1L1, BBS2, ZNF513, IFT172, PDE6A, IFT140, NR2E3, NEK2, CA4, RHO, TTC8
photoreceptor cell differentiation (GO:0046530)	-	7.24	0.038	TTC8, PROM1, ROM1
cilium organization (GO:0044782)	-	4.67	0.0	FAM161A, IFT140, IFT172, ARL6, TTC8, BBS2, RPGR
photoreceptor cell maintenance (GO:0045494)	-	6.17	0.0	CNGB1, MYO7A, RDH12, RP1L1, PROM1, TULP1, CDHR1, ABCA4, MAK, RP1, CLRN1, BBS2, USH2A

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cell part (GO:0044464)	0.11	66	CRX, PRPF8, RGR, RDH12, CYGB, PRPF4, TOPORS, CERKL, ZNF408, CDHR1, PRCD, SNRNP200, KLHL7, PRPH2, BBS2, ABCA4, FSCN2, FAM161A, PRPF3, RP9, PANK2, CRB1, C8orf37, SLC7A14, OFD1, RPE65, ZNF513, ROM1, PDE6G, ARL6, KIZ, CLRN1, SAG, USH2A, BEST1, CNGB1, RHO, MERTK, NRL, RP1L1, SEMA4A, PDE6A, TULP1, PRPF31, MYO7A, PDE6B, RP1, IDH3B, HGSNAT, IMPDH1, CNGA1, IFT172, PRPF6, DHDDS, MAK, RP2, IFT140, NR2E3, NEK2, C2orf71, CA4, RPGR, LRAT, GUCA1B, TTC8, PROM1
organelle (GO:0043226)	0.4	56	CRX, PRPF8, MYO7A, NR2E3, TOPORS, CERKL, ZNF408, SNRNP200, KLHL7, PRPH2, BBS2, ABCA4, FSCN2, FAM161A, PRPF3, RP9, PANK2, RBP3, OFD1, RPE65, ZNF513, ROM1, ARL6, SAG, USH2A, KIZ, CNGB1, SLC7A14, MERTK, NRL, RP1L1, EYS, TULP1, PRPF31, PDE6B, RHO, RP1, IDH3B, HGSNAT, IMPDH1, CNGA1, IFT172, PRPF6, DHDDS, MAK, RP2, IFT140, PRPF4, NEK2, C2orf71, CA4, RPGR, LRAT, GUCA1B, TTC8, PROM1
intracellular part (GO:0044424)	0.28	53	CRX, PRPF8, BEST1, NR2E3, TOPORS, CERKL, CYGB, ZNF408, SNRNP200, KLHL7, BBS2, ABCA4, FSCN2, FAM161A, PRPF3, RP9, PANK2, PRCD, C8orf37, OFD1, RPE65, ZNF513, ARL6, SAG, RPGR, KIZ, CNGB1, SLC7A14, MERTK, NRL, RP1L1, TULP1, PRPF31, MYO7A, MAK, RHO, RP1, IDH3B, HGSNAT, IMPDH1, IFT172, PRPF6, DHDDS, RP2, IFT140, PRPF4, NEK2, CA4, USH2A, LRAT, GUCA1B, TTC8, PROM1
organelle part (GO:0044422)	0.79	48	PRPF8, MYO7A, NR2E3, TOPORS, CNGB1, CDHR1, SNRNP200, KLHL7, BBS2, FSCN2, FAM161A, PDE6B, RP9, PANK2, OFD1, RPE65, ROM1, PDE6G, ARL6, ABCA4, RPGR, KIZ, CERKL, SLC7A14, PRPF3, PDE6A, RP1L1, PRPF31, MAK, RHO, RP1, IDH3B, HGSNAT, IMPDH1, CNGA1, IFT172, PRPF6, DHDDS, RP2, IFT140, PRPF4, NEK2, CA4, USH2A, LRAT, GUCA1B, TTC8, PROM1
intracellular organelle (GO:0043229)	0.51	42	CRX, PRPF8, MYO7A, NR2E3, TOPORS, ZNF408, SNRNP200, KLHL7, BBS2, FSCN2, FAM161A, RP9, PANK2, OFD1, RPE65, ZNF513, HGSNAT, ABCA4, RPGR, KIZ, CERKL, SLC7A14, PRPF3, NRL, RP1L1, PRPF31, MAK, RHO, RP1, IDH3B, ARL6, IMPDH1, PRPF6, DHDDS, RP2, IFT140, PRPF4, NEK2, CA4, LRAT, TTC8, PROM1
membrane (GO:0016020)	0.68	41	PRPF8, SNRNP200, RDH12, ABCA4, CDHR1, CRB1, RGR, KLHL7, PRPH2, BBS2, KIZ, PDE6B, PROM1, PRCD, C8orf37, SLC7A14, OFD1, RPE65, ROM1, PDE6G, ARL6, CLRN1, USH2A, BEST1, CNGB1, RHO, MERTK, PDE6A, SEMA4A, TULP1, MYO7A, IMPG2, HGSNAT, CNGA1, PRPF6, DHDDS, RP2, CA4, LRAT, GUCA1B, TTC8
intracellular organelle part (GO:0044446)	0.81	38	PRPF8, MYO7A, NR2E3, TOPORS, CERKL, SNRNP200, KLHL7, BBS2, KIZ, FAM161A, RP9, PANK2, OFD1, ARL6, MAK, USH2A, CNGB1, SLC7A14, PRPF3, RP1L1, PRPF31, RHO, RP1, IDH3B, HGSNAT, IMPDH1, IFT172, PRPF6, DHDDS, RP2, IFT140, PRPF4, NEK2, CA4, RPGR, LRAT, GUCA1B, TTC8
membrane-bounded organelle (GO:0043227)	0.47	38	CRX, PRPF8, MYO7A, NR2E3, TOPORS, ZNF408, SNRNP200, KLHL7, RP9, PANK2, RBP3, OFD1, RPE65, IMPDH1, ARL6, ABCA4, RPGR, CERKL, SLC7A14, PRPF3, NRL, EYS, RP1L1, PRPF31, RHO, IDH3B, HGSNAT, ZNF513, IFT172, PRPF6, DHDDS, RP2, MAK, PRPF4, NEK2, CA4, LRAT, PROM1
membrane part (GO:0044425)	0.95	35	IMPG2, RDH12, ABCA4, CDHR1, PRCD, RGR, PRPH2, KIZ, PDE6B, RP9, CRB1, OFD1, ROM1, PDE6G, ARL6, CLRN1, USH2A, BEST1, CNGB1, SLC7A14, MERTK, SEMA4A, PDE6A, MYO7A, RHO, BBS2, HGSNAT, CNGA1, DHDDS, RP2, CA4, LRAT, GUCA1B, TTC8, PROM1
cell projection (GO:0042995)	2.47	33	MYO7A, SAG, CNGB1, ABCA4, PRPH2, BBS2, FSCN2, FAM161A, PDE6B, PROM1, CRB1, OFD1, ROM1, ARL6, CLRN1, TOPORS, USH2A, KIZ, CYGB, MERTK, RP1L1, TULP1, MAK, RP1, GUCA1B, CNGA1, IFT172, RP2, IFT140, C2orf71, RPGR, RHO, TTC8
intracellular membrane-bounded organelle (GO:0043231)	0.6	33	CRX, KLHL7, MYO7A, NR2E3, TOPORS, ZNF408, SNRNP200, PRPF8, RP9, PANK2, OFD1, RPE65, IMPDH1, HGSNAT, ABCA4, RPGR, CERKL, SLC7A14, PRPF3, NRL, PRPF31, RHO, IDH3B, ZNF513, PRPF6, DHDDS, RP2, MAK, PRPF4, NEK2, CA4, LRAT, PROM1
cytoplasm (GO:0005737)	1.01	29	KLHL7, MAK, CERKL, MYO7A, BBS2, FSCN2, FAM161A, PRPF3, RP9, PANK2, PRCD, C8orf37, OFD1, RPE65, ARL6, RPGR, KIZ, CYGB, MERTK, TULP1, RP1L1, RP1, IMPDH1, RP2, IFT140, NEK2, USH2A, LRAT, TTC8
cilium (GO:0005929)	3.89	28	MYO7A, SAG, ABCA4, PRPH2, BBS2, FAM161A, PDE6B, PROM1, OFD1, ROM1, ARL6, TOPORS, RPGR, CNGB1, MERTK, TULP1, RP1L1, MAK, RP1, GUCA1B, CNGA1, IFT172, RP2, IFT140, C2orf71, USH2A, RHO, TTC8
cytoplasmic part (GO:0044444)	0.82	27	MYO7A, SAG, CERKL, CNGB1, BEST1, RP9, PANK2, OFD1, RPE65, ARL6, TOPORS, RPGR, CYGB, LRAT, TULP1, RHO, BBS2, IDH3B, HGSNAT, IMPDH1, DHDDS, RP2, NEK2, CA4, SLC7A14, TTC8, PROM1
cell projection part (GO:0044463)	2.97	27	ABCA4, CDHR1, MYO7A, BBS2, FAM161A, PROM1, OFD1, ROM1, PDE6G, ARL6, TOPORS, USH2A, CNGB1, PDE6B, PDE6A, RP1L1, TULP1, RP1, GUCA1B, CNGA1, IFT172, RP2, IFT140, CA4, RPGR, RHO, TTC8
neuron part (GO:0097458)	2.64	26	RDH12, SAG, CNGB1, CDHR1, MYO7A, PRPH2, FSCN2, PDE6B, PROM1, ROM1, GUCA1B, ABCA4, USH2A, CYGB, MERTK, RP1L1, PDE6A, TULP1, RP1, CNGA1, MAK, IFT140, C2orf71, PDE6G, RPGR, RHO
primary cilium (GO:0072372)	4.64	26	MYO7A, SAG, ABCA4, PRPH2, FAM161A, MERTK, PROM1, ROM1, ARL6, TOPORS, RPGR, CNGB1, PDE6B, TULP1, RP1L1, MAK, RP1, GUCA1B, CNGA1, IFT172, RP2, IFT140, C2orf71, USH2A, RHO, TTC8
plasma membrane part (GO:0044459)	1.95	25	BEST1, RDH12, ABCA4, CDHR1, RGR, PRPH2, MERTK, PROM1, CRB1, ROM1, CA4, ARL6, USH2A, CNGB1, SLC7A14, PDE6B, PDE6A, MYO7A, BBS2, GUCA1B, CNGA1, RP2, PDE6G, RHO, TTC8
integral component of membrane (GO:0016021)	1.14	24	RGR, ABCA4, CDHR1, PRCD, IMPG2, PRPH2, KIZ, PDE6B, PROM1, CRB1, OFD1, ROM1, HGSNAT, CLRN1, USH2A, BEST1, CNGB1, SLC7A14, MERTK, SEMA4A, RHO, CNGA1, CA4, LRAT
plasma membrane (GO:0005886)	1.39	24	KLHL7, CDHR1, BEST1, MERTK, PROM1, CRB1, C8orf37, RPE65, PDE6G, ARL6, CLRN1, USH2A, CNGB1, PDE6B, TULP1, SEMA4A, PDE6A, BBS2, GUCA1B, CNGA1, RP2, CA4, RHO, TTC8
intrinsic component of membrane (GO:0031224)	1.13	24	RGR, ABCA4, CDHR1, CRB1, IMPG2, PRPH2, KIZ, PDE6B, PROM1, PRCD, OFD1, ROM1, HGSNAT, CLRN1, USH2A, BEST1, CNGB1, SLC7A14, MERTK, SEMA4A, RHO, CNGA1, CA4, LRAT
ciliary part (GO:0044441)	4.05	24	TOPORS, CDHR1, RP1, FAM161A, PROM1, OFD1, ROM1, ARL6, ABCA4, USH2A, CNGB1, PDE6B, RP1L1, PDE6A, BBS2, GUCA1B, CNGA1, IFT172, RP2, IFT140, PDE6G, RPGR, RHO, TTC8
nonmotile primary cilium (GO:0031513)	5.14	23	ABCA4, SAG, MYO7A, PRPH2, FAM161A, MERTK, PROM1, ROM1, GUCA1B, MAK, USH2A, CNGB1, PDE6B, TULP1, RP1L1, RP1, CNGA1, IFT140, C2orf71, TOPORS, RPGR, RHO, TTC8
macromolecular complex (GO:0032991)	1.35	22	KLHL7, IMPG2, PRPF4, TOPORS, BEST1, PRPF8, RP1, RP9, ARL6, USH2A, CNGB1, PRPF3, SNRNP200, PRPF31, MYO7A, BBS2, IFT172, PRPF6, IFT140, NR2E3, NEK2, TTC8
plasma membrane region (GO:0098590)	2.97	21	CNGA1, BEST1, CNGB1, ROM1, PDE6B, RP2, PROM1, PDE6A, GUCA1B, CRB1, ARL6, RDH12, CDHR1, RHO, CA4, PDE6G, BBS2, MYO7A, TTC8, USH2A, ABCA4
nucleus (GO:0005634)	1.07	20	CRX, PRPF6, PRPF8, PRPF3, ZNF408, NRL, PRPF4, RP9, NR2E3, CERKL, NEK2, OFD1, PRPF31, ZNF513, SNRNP200, KLHL7, TOPORS, IDH3B, MAK, IMPDH1
photoreceptor outer segment (GO:0001750)	5.78	19	CNGA1, CNGB1, SAG, ROM1, PDE6B, MERTK, RP1L1, PROM1, TULP1, GUCA1B, C2orf71, RHO, MYO7A, MAK, RP1, PRPH2, IFT140, RPGR, ABCA4
organelle membrane (GO:0031090)	1.97	19	CNGA1, CA4, CNGB1, ROM1, PDE6B, PROM1, PDE6A, GUCA1B, ARL6, PDE6G, HGSNAT, RPE65, SLC7A14, CDHR1, RHO, BBS2, MYO7A, TTC8, ABCA4
protein complex (GO:0043234)	1.51	18	IFT172, KLHL7, BEST1, MYO7A, IFT140, NR2E3, CNGB1, NEK2, ARL6, PRPF31, BBS2, TTC8, IMPG2, PRPF3, RP1, TOPORS, RP9, USH2A
bounding membrane of organelle (GO:0098588)	2.39	18	CNGA1, CA4, CNGB1, RHO, PDE6B, ABCA4, PDE6A, GUCA1B, ARL6, SLC7A14, PROM1, CDHR1, TTC8, ROM1, MYO7A, PDE6G, HGSNAT, BBS2
non-membrane-bounded organelle (GO:0043228)	1.76	18	KIZ, FSCN2, FAM161A, KLHL7, RP2, IFT140, RP1L1, CERKL, NEK2, ARL6, OFD1, TOPORS, TTC8, MYO7A, MAK, RP1, BBS2, RPGR
cytoskeletal part (GO:0044430)	2.49	18	KIZ, FAM161A, RP2, IFT140, RP1L1, IFT172, NEK2, ARL6, OFD1, TOPORS, TTC8, MYO7A, GUCA1B, MAK, RP1, RPGR, BBS2, USH2A
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	18	KIZ, FSCN2, FAM161A, KLHL7, RP2, IFT140, RP1L1, CERKL, NEK2, ARL6, OFD1, TOPORS, TTC8, MYO7A, MAK, RP1, BBS2, RPGR
cell projection membrane (GO:0031253)	4.11	16	CNGA1, CNGB1, RHO, PDE6B, PROM1, PDE6A, PDE6G, ARL6, CDHR1, ROM1, GUCA1B, CA4, BBS2, TTC8, USH2A, ABCA4
ciliary membrane (GO:0060170)	5.43	14	CNGA1, CNGB1, RHO, PDE6B, ABCA4, PDE6A, ARL6, PROM1, CDHR1, ROM1, GUCA1B, PDE6G, TTC8, BBS2
cytoskeleton (GO:0005856)	2.55	14	KIZ, FSCN2, FAM161A, IFT140, RP1L1, NEK2, ARL6, OFD1, TTC8, MYO7A, MAK, RP1, BBS2, RPGR
intrinsic component of plasma membrane (GO:0031226)	2.53	13	CNGA1, BEST1, CNGB1, RGR, MERTK, ABCA4, ROM1, SLC7A14, CA4, RHO, CDHR1, PRPH2, PROM1
microtubule organizing center (GO:0005815)	3.42	13	KIZ, FAM161A, RP2, IFT140, IFT172, NEK2, OFD1, TOPORS, RPGR, MAK, BBS2, TTC8, USH2A
cytosol (GO:0005829)	1.68	12	CYGB, MYO7A, PANK2, SAG, TULP1, NEK2, ARL6, OFD1, BEST1, BBS2, TTC8, IMPDH1
nuclear part (GO:0044428)	1.55	12	CERKL, KLHL7, PRPF3, PRPF4, TOPORS, NR2E3, NEK2, PRPF31, SNRNP200, PRPF8, PRPF6, IMPDH1
extracellular region part (GO:0044421)	1.57	12	IFT172, RBP3, MERTK, SEMA4A, EYS, RP1L1, RP2, CA4, IMPG2, ARL6, PROM1, USH2A
integral component of plasma membrane (GO:0005887)	2.57	12	CNGA1, BEST1, CNGB1, RGR, MERTK, ABCA4, ROM1, SLC7A14, CDHR1, RHO, PRPH2, PROM1
ciliary basal body (GO:0036064)	5.36	10	FAM161A, RP2, IFT140, IFT172, OFD1, TOPORS, RPGR, BBS2, TTC8, USH2A
nucleoplasm (GO:0005654)	1.89	9	KLHL7, PRPF3, PRPF4, NR2E3, PRPF6, PRPF31, SNRNP200, PRPF8, IMPDH1
vesicle (GO:0031982)	1.64	9	IFT172, MYO7A, RP2, EYS, RP1L1, CA4, RBP3, ARL6, PROM1
photoreceptor inner segment (GO:0001917)	6.25	8	MYO7A, MAK, TULP1, RHO, GUCA1B, RP1, SAG, USH2A
photoreceptor connecting cilium (GO:0032391)	6.28	8	FAM161A, IFT140, RP1L1, TOPORS, MYO7A, TTC8, RP1, USH2A
extracellular vesicle (GO:1903561)	1.89	8	IFT172, RP2, EYS, RP1L1, CA4, RBP3, ARL6, PROM1
extracellular organelle (GO:0043230)	1.89	8	IFT172, RP2, EYS, RP1L1, CA4, RBP3, ARL6, PROM1
centrosome (GO:0005813)	3.75	8	KIZ, FAM161A, IFT140, NEK2, OFD1, TTC8, MAK, RPGR
membrane-bounded vesicle (GO:0031988)	1.71	7	RP2, PROM1, RP1L1, CA4, MYO7A, ARL6, EYS
photoreceptor disc membrane (GO:0097381)	6.91	6	PDE6B, ABCA4, PDE6A, PDE6G, RHO, GUCA1B
nuclear speck (GO:0016607)	4.52	6	PRPF6, PRPF3, TOPORS, PRPF4, PRPF31, PRPF8
nuclear body (GO:0016604)	3.94	6	PRPF6, PRPF3, TOPORS, PRPF4, PRPF31, PRPF8
endoplasmic reticulum (GO:0005783)	2.56	6	CERKL, DHDDS, PROM1, CA4, LRAT, RPE65
small nuclear ribonucleoprotein complex (GO:0030532)	5.68	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
whole membrane (GO:0098805)	2.85	6	CNGB1, SLC7A14, MYO7A, CA4, RHO, HGSNAT
ribonucleoprotein complex (GO:1990904)	3.19	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
intracellular ribonucleoprotein complex (GO:0030529)	3.19	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
spliceosomal snRNP complex (GO:0097525)	5.79	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
nucleoplasm part (GO:0044451)	3.22	6	PRPF6, PRPF3, TOPORS, PRPF4, PRPF31, PRPF8
spliceosomal complex (GO:0005681)	4.65	6	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
extracellular exosome (GO:0070062)	1.89	6	RP2, PROM1, RP1L1, CA4, ARL6, EYS
Golgi apparatus (GO:0005794)	2.7	5	RP2, CERKL, CA4, RHO, RPGR
supramolecular fiber (GO:0099512)	3.31	5	RP1, RP1L1, GUCA1B, NEK2, ARL6
polymeric cytoskeletal fiber (GO:0099513)	3.31	5	RP1, RP1L1, GUCA1B, NEK2, ARL6
photoreceptor outer segment membrane (GO:0042622)	7.09	5	CNGA1, PROM1, CDHR1, ROM1, RHO
apical plasma membrane (GO:0016324)	4.13	5	PROM1, USH2A, CA4, MYO7A, CRB1
extracellular region (GO:0005576)	2.18	5	EYS, USH2A, TULP1, CRB1, RBP3
axoneme (GO:0005930)	5.53	5	RP1L1, RP1, IFT140, IFT172, ARL6
U4/U6 x U5 tri-snRNP complex (GO:0046540)	6.67	4	PRPF6, PRPF31, PRPF4, PRPF3
extracellular space (GO:0005615)	2.63	4	MERTK, SEMA4A, PROM1, RBP3
membrane protein complex (GO:0098796)	2.84	4	CNGB1, RP9, BEST1, ARL6
endoplasmic reticulum part (GO:0044432)	2.73	4	RHO, RP9, DHDDS, LRAT
spliceosomal tri-snRNP complex (GO:0097526)	6.47	4	PRPF6, PRPF31, PRPF4, PRPF3
actin-based cell projection (GO:0098858)	4.83	4	FSCN2, CLRN1, CRB1, MYO7A
microtubule (GO:0005874)	3.81	4	RP1, RP1L1, ARL6, NEK2
cell junction (GO:0030054)	2.75	4	C8orf37, TULP1, RHO, IMPDH1
BBSome (GO:0034464)	7.5	3	BBS2, TTC8, ARL6
intracellular (GO:0005622)	2.37	3	ARL6, RP1L1, RDH12
catalytic complex (GO:1902494)	2.9	3	PRPF31, KLHL7, TOPORS
nucleolus (GO:0005730)	3.06	3	CERKL, KLHL7, NEK2
vacuole (GO:0005773)	2.92	3	HGSNAT, LRAT, SLC7A14
catalytic step 2 spliceosome (GO:0071013)	5.32	3	PRPF6, PRPF8, SNRNP200
midbody (GO:0030496)	4.95	3	MAK, TOPORS, NEK2
microvillus (GO:0005902)	5.69	3	CLRN1, CRB1, MYO7A
centriole (GO:0005814)	5.15	3	RP2, OFD1, TOPORS
endoplasmic reticulum membrane (GO:0005789)	2.95	3	RHO, DHDDS, LRAT
cytoplasmic vesicle part (GO:0044433)	3.41	3	CNGB1, CA4, RHO
lysosomal membrane (GO:0005765)	4.19	3	HGSNAT, MYO7A, SLC7A14
Golgi apparatus part (GO:0044431)	3.0	3	CNGB1, CA4, RHO
vacuolar part (GO:0044437)	3.26	3	HGSNAT, MYO7A, SLC7A14
intracellular vesicle (GO:0097708)	2.86	3	RP2, IFT172, MYO7A
transferase complex (GO:1990234)	3.32	3	PRPF31, KLHL7, TOPORS
Cajal body (GO:0015030)	5.85	3	PRPF31, PRPF4, PRPF3
vacuolar membrane (GO:0005774)	3.45	3	HGSNAT, MYO7A, SLC7A14
U5 snRNP (GO:0005682)	6.97	3	PRPF8, PRPF6, SNRNP200
lytic vacuole membrane (GO:0098852)	4.19	3	HGSNAT, MYO7A, SLC7A14
microtubule organizing center part (GO:0044450)	4.8	3	RP2, OFD1, TOPORS
lytic vacuole (GO:0000323)	3.89	2	HGSNAT, SLC7A14
photoreceptor inner segment membrane (GO:0060342)	9.11	2	RDH12, RHO
periciliary membrane compartment (GO:1990075)	8.42	2	RP2, USH2A
membrane-enclosed lumen (GO:0031974)	3.05	2	PANK2, IDH3B
extracellular matrix (GO:0031012)	3.81	2	IMPG2, RBP3
synapse (GO:0045202)	3.58	2	TULP1, MYO7A
transmembrane transporter complex (GO:1902495)	4.06	2	CNGB1, BEST1
microtubule associated complex (GO:0005875)	4.79	2	RP1, TOPORS
Golgi-associated vesicle membrane (GO:0030660)	6.19	2	CNGB1, RHO
intracellular organelle lumen (GO:0070013)	3.05	2	PANK2, IDH3B
motile cilium (GO:0031514)	5.36	2	BBS2, RPGR
cytoplasmic vesicle (GO:0031410)	2.87	2	RP2, MYO7A
sperm part (GO:0097223)	4.83	2	IFT172, RPGR
mitochondrion (GO:0005739)	2.42	2	PANK2, IDH3B
spindle pole (GO:0000922)	5.08	2	TOPORS, NEK2
viral nucleocapsid (GO:0019013)	6.97	2	PRPF31, SNRNP200
perinuclear region of cytoplasm (GO:0048471)	3.35	2	CA4, LRAT
stereocilium (GO:0032420)	6.4	2	FSCN2, MYO7A
rough endoplasmic reticulum (GO:0005791)	5.83	2	CA4, LRAT
endoplasmic reticulum-Golgi intermediate compartment (GO:0005793)	5.63	2	PROM1, CA4
transporter complex (GO:1990351)	4.04	2	CNGB1, BEST1
cell surface (GO:0009986)	3.44	2	PROM1, CA4
cell body (GO:0044297)	3.74	2	CYGB, RPE65
basolateral plasma membrane (GO:0016323)	4.56	2	CA4, BEST1
interphotoreceptor matrix (GO:0033165)	9.11	2	IMPG2, RBP3
organelle lumen (GO:0043233)	3.05	2	IDH3B, PANK2
ubiquitin ligase complex (GO:0000151)	4.23	2	TOPORS, KLHL7
Golgi membrane (GO:0000139)	3.28	2	CNGB1, RHO
lysosome (GO:0005764)	3.89	2	HGSNAT, SLC7A14
ciliary tip (GO:0097542)	6.04	2	IFT172, IFT140
mitochondrial part (GO:0044429)	2.92	2	IDH3B, PANK2
proteinaceous extracellular matrix (GO:0005578)	4.01	2	IMPG2, RBP3
virion part (GO:0044423)	6.06	2	PRPF31, SNRNP200

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
plasma membrane region (GO:0098590)	-	2.97	0.0	CNGA1, BEST1, CNGB1, PRPF8, RHO, PDE6B, PROM1, PDE6A, GUCA1B, CRB1, ARL6, CA4, CDHR1, TTC8, ROM1, MYO7A, PDE6G, RP1, BBS2, USH2A, ABCA4
photoreceptor inner segment membrane (GO:0060342)	-	9.11	0.003	RHO, RDH12
U4/U6 x U5 tri-snRNP complex (GO:0046540)	-	6.67	0.0	PRPF31, PRPF6, PRPF3
ciliary membrane (GO:0060170)	-	5.43	0.0	CNGA1, CNGB1, RHO, PDE6B, ABCA4, PDE6A, ARL6, PROM1, CDHR1, ROM1, GUCA1B, PDE6G, TTC8, BBS2
U4/U6 snRNP (GO:0071001)	NEW	8.7	0.008	PRPF6, PRPF4
microvillus (GO:0005902)	-	5.69	0.001	FSCN2, PROM1, CLRN1, CRB1, MYO7A
cilium (GO:0005929)	-	3.89	0.0	FAM161A, BBS2, MERTK, PDE6B, RP1L1, PROM1, SAG, TULP1, IFT172, NEK2, C2orf71, OFD1, TOPORS, TTC8, RHO, MYO7A, MAK, RP1, RPGR, IFT140, USH2A
nonmotile primary cilium (GO:0031513)	-	5.14	0.0	FAM161A, MYO7A, MERTK, RP1L1, IFT140, TULP1, IFT172, C2orf71, PROM1, TOPORS, TTC8, RHO, MAK, RP1, SAG, RPGR
nuclear speck (GO:0016607)	-	4.52	0.008	PRPF6, PRPF3, TOPORS, PRPF4, PRPF31, PRPF8
ciliary basal body (GO:0036064)	-	5.36	0.0	FAM161A, RP2, IFT140, IFT172, OFD1, TOPORS, SNRNP200, BBS2, TTC8, RPGR
primary cilium (GO:0072372)	-	4.64	0.0	IFT172, SAG, MYO7A, MERTK, RP1L1, PROM1, TULP1, FAM161A, NEK2, C2orf71, TOPORS, TTC8, RHO, MAK, RP1, IFT140, RPGR
photoreceptor outer segment membrane (GO:0042622)	-	7.09	0.0	CNGA1, CNGB1, ROM1, PROM1, CDHR1, RHO
centrosome (GO:0005813)	-	3.75	0.011	KIZ, FAM161A, IFT140, NEK2, OFD1, TTC8, MAK, RPGR
axoneme (GO:0005930)	-	5.53	0.0	RP1L1, RP1, IFT140, IFT172, ARL6
neuron part (GO:0097458)	-	2.64	0.0	CRX, RDH12, NR2E3, SAG, CNGB1, CDHR1, MYO7A, PDE6B, PROM1, CRB1, ROM1, GUCA1B, ABCA4, USH2A, CYGB, MERTK, TULP1, RP1L1, PRPF31, RP1, CNGA1, PDE6A, MAK, PRPF4, C2orf71, PDE6G, RPGR, RHO
cytoskeletal part (GO:0044430)	-	2.49	0.011	KIZ, FAM161A, RP2, IFT140, RP1L1, IFT172, NEK2, ARL6, OFD1, TOPORS, TTC8, MYO7A, MAK, RP1, BBS2, RPGR
plasma membrane part (GO:0044459)	-	1.95	0.002	RGR, ABCA4, CDHR1, TTC8, BEST1, PDE6B, PROM1, CRB1, ROM1, CA4, GUCA1B, USH2A, CNGB1, MERTK, PDE6A, BBS2, ARL6, CNGA1, RP2, PDE6G, RHO, MYO7A
stereocilium (GO:0032420)	-	6.4	0.019	FSCN2, PROM1, MYO7A
photoreceptor connecting cilium (GO:0032391)	-	6.28	0.0	IFT172, IFT140, RP1L1, FAM161A, TOPORS, MYO7A, TTC8, RP1
bounding membrane of organelle (GO:0098588)	-	2.39	0.015	CNGA1, CA4, MYO7A, RHO, DHDDS, PDE6A, ABCA4, PDE6B, ARL6, ROM1, PROM1, CDHR1, TTC8, SLC7A14, GUCA1B, PDE6G, HGSNAT, LRAT, BBS2
membrane region (GO:0098589)	NEW	3.95	0.0	CNGA1, BEST1, MYO7A, ROM1, DHDDS, PDE6A, ABCA4, PDE6B, PDE6G, CRB1, ARL6, PROM1, CDHR1, RHO, GUCA1B, CA4, BBS2, LRAT, TTC8, USH2A
cell projection membrane (GO:0031253)	-	4.11	0.0	CNGA1, CA4, CNGB1, ROM1, PDE6B, RP2, ABCA4, PDE6A, ARL6, PROM1, CDHR1, RHO, GUCA1B, PDE6G, BBS2, TTC8, USH2A
cell projection (GO:0042995)	-	2.47	0.0	PRPF8, TOPORS, CNGB1, MYO7A, BBS2, FSCN2, FAM161A, PDE6B, PROM1, CRB1, OFD1, CLRN1, SAG, USH2A, CYGB, MERTK, RP1L1, TULP1, PRPF31, MAK, RP1, IFT172, IFT140, PRPF4, C2orf71, RPGR, RHO, TTC8
photoreceptor outer segment (GO:0001750)	-	5.78	0.0	MYO7A, MERTK, RP1L1, SAG, TULP1, C2orf71, RHO, MAK, RP1, PROM1, RPGR
photoreceptor disc membrane (GO:0097381)	-	6.91	0.0	CNGB1, PDE6B, ABCA4, PDE6A, PDE6G, RHO, GUCA1B
microtubule organizing center (GO:0005815)	-	3.42	0.0	KIZ, FAM161A, RP2, IFT140, IFT172, NEK2, OFD1, TOPORS, MAK, BBS2, TTC8, RPGR
small nuclear ribonucleoprotein complex (GO:0030532)	-	5.68	0.0	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
cell projection part (GO:0044463)	-	2.97	0.0	CRX, MYO7A, TOPORS, CDHR1, SNRNP200, BBS2, FAM161A, PROM1, OFD1, ROM1, PDE6G, ARL6, ABCA4, USH2A, CNGB1, PDE6B, PDE6A, RP1L1, MAK, RP1, GUCA1B, CNGA1, IFT172, RP2, IFT140, NR2E3, NEK2, CA4, RPGR, RHO, TTC8
spliceosomal snRNP complex (GO:0097525)	-	5.79	0.0	PRPF31, PRPF6, PRPF3
spliceosomal tri-snRNP complex (GO:0097526)	-	6.47	0.0	PRPF31, PRPF6, PRPF3
photoreceptor inner segment (GO:0001917)	-	6.25	0.0	MYO7A, MAK, TULP1, RHO, GUCA1B, RP1, SAG
spliceosomal complex (GO:0005681)	-	4.65	0.004	PRPF6, PRPF3, PRPF4, PRPF31, SNRNP200, PRPF8
ciliary part (GO:0044441)	-	4.05	0.0	TOPORS, CDHR1, SNRNP200, RP1, FAM161A, PROM1, OFD1, ROM1, ARL6, ABCA4, RPGR, CNGB1, PDE6B, RP1L1, PDE6A, BBS2, GUCA1B, CNGA1, IFT172, RP2, IFT140, PDE6G, RHO, TTC8
U5 snRNP (GO:0005682)	-	6.97	0.0	PRPF8, PRPF6, SNRNP200
organelle part (GO:0044422)	-	0.79	0.0	PRPF8, MYO7A, NR2E3, TOPORS, CDHR1, SNRNP200, KLHL7, BBS2, FSCN2, FAM161A, PDE6B, RP9, PANK2, OFD1, RPE65, ROM1, PDE6G, ARL6, ABCA4, RPGR, KIZ, CERKL, SLC7A14, PRPF3, PDE6A, RP1L1, PRPF31, MAK, RHO, RP1, IDH3B, HGSNAT, CNGA1, IFT172, PRPF6, DHDDS, RP2, IFT140, PRPF4, NEK2, CA4, USH2A, LRAT, GUCA1B, TTC8, PROM1