Disease table of HYPEROXALURIA, PRIMARY OMIM ID: PS259900

Gene-disease associations table

GeneAssociated with HYPEROXALURIA, PRIMARY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
HOGA1ClinVar, OMIM, HUMSAVARHGNC link10q24.21PS259900
GRHPRClinVar, OMIMHGNC link9p13.21PS259900
AGXTClinVar, OMIM, HUMSAVARHGNC link2q37.31PS259900

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.493GRHPR, HOGA1, AGXT
Glyoxylate and dicarboxylate metabolismhsa006308.073GRHPR, HOGA1, AGXT
Glycine, serine and threonine metabolismhsa002607.452GRHPR, AGXT

NET-GE enrichment

Term New enriched termICP valueGenes
Glycine, serine and threonine metabolism (hsa00260) -7.450.002GRHPR, AGXT
Glyoxylate and dicarboxylate metabolism (hsa00630) -8.070.0GRHPR, HOGA1, AGXT
Amino acid metabolismNEW4.630.006GRHPR, HOGA1, AGXT
Carbohydrate metabolismNEW4.360.002GRHPR, HOGA1, AGXT
Arginine and proline metabolism (hsa00330) NEW6.840.006HOGA1, AGXT
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Metabolism of amino acids and derivativesR-HSA-712915.42GRHPR, AGXT
MetabolismR-HSA-14307282.342GRHPR, AGXT
Glyoxylate metabolismR-HSA-38966110.662GRHPR, AGXT

NET-GE enrichment

Term New enriched termICP valueGenes
Metabolism of amino acids and derivatives (R-HSA-71291) -5.40.002GRHPR, AGXT
Glyoxylate metabolism (R-HSA-389661) -10.660.0GRHPR, AGXT
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
catalytic activity (GO:0003824) 1.053GRHPR, HOGA1, AGXT
binding (GO:0005488) 0.183GRHPR, HOGA1, AGXT
protein binding (GO:0005515) 0.463GRHPR, HOGA1, AGXT
protein dimerization activity (GO:0046983) 2.723GRHPR, HOGA1, AGXT
identical protein binding (GO:0042802) 2.633GRHPR, HOGA1, AGXT
protein homodimerization activity (GO:0042803) 3.163GRHPR, HOGA1, AGXT
anion binding (GO:0043168) 4.172GRHPR, AGXT
carboxylic acid binding (GO:0031406) 4.642GRHPR, AGXT
cofactor binding (GO:0048037) 4.162GRHPR, AGXT
ion binding (GO:0043167) 1.362GRHPR, AGXT

NET-GE enrichment

Term New enriched termICP valueGenes
carboxylic acid binding (GO:0031406) -4.640.013GRHPR, AGXT
organic acid binding (GO:0043177) NEW6.60.014GRHPR, AGXT
cofactor binding (GO:0048037) -4.160.032GRHPR, AGXT
protein dimerization activity (GO:0046983) -2.720.008GRHPR, HOGA1, AGXT
identical protein binding (GO:0042802) -2.630.008GRHPR, HOGA1, AGXT
protein homodimerization activity (GO:0042803) -3.160.002GRHPR, HOGA1, AGXT
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
single-organism metabolic process (GO:0044710) 1.633GRHPR, HOGA1, AGXT
organic acid metabolic process (GO:0006082) 3.013GRHPR, HOGA1, AGXT
cellular metabolic process (GO:0044237) 0.693GRHPR, HOGA1, AGXT
cellular process (GO:0009987) 0.263GRHPR, HOGA1, AGXT
carboxylic acid metabolic process (GO:0019752) 3.123GRHPR, HOGA1, AGXT
monocarboxylic acid metabolic process (GO:0032787) 3.573GRHPR, HOGA1, AGXT
organic substance metabolic process (GO:0071704) 0.633GRHPR, HOGA1, AGXT
single-organism cellular process (GO:0044763) 0.653GRHPR, HOGA1, AGXT
small molecule metabolic process (GO:0044281) 2.383GRHPR, HOGA1, AGXT
metabolic process (GO:0008152) 0.583GRHPR, HOGA1, AGXT
oxoacid metabolic process (GO:0043436) 3.123GRHPR, HOGA1, AGXT
glyoxylate metabolic process (GO:0046487) 6.43GRHPR, HOGA1, AGXT
single-organism process (GO:0044699) 0.483GRHPR, HOGA1, AGXT
cellular catabolic process (GO:0044248) 2.622HOGA1, AGXT
cellular biosynthetic process (GO:0044249) 1.372HOGA1, AGXT
glyoxylate catabolic process (GO:0009436) 8.632HOGA1, AGXT
nitrogen compound metabolic process (GO:0006807) 1.132HOGA1, AGXT
small molecule catabolic process (GO:0044282) 3.992HOGA1, AGXT
small molecule biosynthetic process (GO:0044283) 3.792HOGA1, AGXT
pyruvate metabolic process (GO:0006090) 5.512HOGA1, AGXT
monocarboxylic acid biosynthetic process (GO:0072330) 4.742HOGA1, AGXT
single-organism catabolic process (GO:0044712) 3.212HOGA1, AGXT
organic substance biosynthetic process (GO:1901576) 1.342HOGA1, AGXT
organic substance catabolic process (GO:1901575) 2.452HOGA1, AGXT
single-organism biosynthetic process (GO:0044711) 2.82HOGA1, AGXT
pyruvate biosynthetic process (GO:0042866) 7.942HOGA1, AGXT
alpha-amino acid metabolic process (GO:1901605) 4.52HOGA1, AGXT
alpha-amino acid catabolic process (GO:1901606) 5.542HOGA1, AGXT
biosynthetic process (GO:0009058) 1.322HOGA1, AGXT
monocarboxylic acid catabolic process (GO:0072329) 5.262HOGA1, AGXT
catabolic process (GO:0009056) 2.382HOGA1, AGXT
dicarboxylic acid metabolic process (GO:0043648) 5.32GRHPR, HOGA1
organonitrogen compound metabolic process (GO:1901564) 2.322HOGA1, AGXT
organonitrogen compound catabolic process (GO:1901565) 3.912HOGA1, AGXT
carboxylic acid biosynthetic process (GO:0046394) 4.322HOGA1, AGXT
carboxylic acid catabolic process (GO:0046395) 4.582HOGA1, AGXT
organic acid catabolic process (GO:0016054) 4.442HOGA1, AGXT
organic acid biosynthetic process (GO:0016053) 4.262HOGA1, AGXT

NET-GE enrichment

Term New enriched termICP valueGenes
cellular amino acid catabolic process (GO:0009063) NEW5.370.015HOGA1, AGXT
glyoxylate metabolic process (GO:0046487) -6.40.0GRHPR, HOGA1, AGXT
aldehyde catabolic process (GO:0046185) NEW7.430.0HOGA1, AGXT
cellular aldehyde metabolic process (GO:0006081) NEW5.740.0GRHPR, HOGA1, AGXT
organic acid metabolic process (GO:0006082) -3.010.021GRHPR, HOGA1, AGXT
dicarboxylic acid metabolic process (GO:0043648) -5.30.008GRHPR, HOGA1
carboxylic acid catabolic process (GO:0046395) -4.580.044HOGA1, AGXT
organic acid catabolic process (GO:0016054) -4.440.044HOGA1, AGXT
carboxylic acid metabolic process (GO:0019752) -3.120.014GRHPR, HOGA1, AGXT
monocarboxylic acid metabolic process (GO:0032787) -3.570.002GRHPR, HOGA1, AGXT
pyruvate biosynthetic process (GO:0042866) -7.940.0HOGA1, AGXT
glyoxylate catabolic process (GO:0009436) -8.630.0HOGA1, AGXT
monocarboxylic acid catabolic process (GO:0072329) -5.260.037HOGA1, AGXT
oxoacid metabolic process (GO:0043436) -3.120.02GRHPR, HOGA1, AGXT
pyruvate metabolic process (GO:0006090) -5.510.021HOGA1, AGXT
monocarboxylic acid biosynthetic process (GO:0072330) -4.740.028HOGA1, AGXT
alpha-amino acid catabolic process (GO:1901606) -5.540.01HOGA1, AGXT
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.283GRHPR, HOGA1, AGXT
cell part (GO:0044464) 0.113GRHPR, HOGA1, AGXT
cytoplasmic part (GO:0044444) 0.823GRHPR, HOGA1, AGXT
membrane-bounded organelle (GO:0043227) 0.473GRHPR, HOGA1, AGXT
organelle (GO:0043226) 0.43GRHPR, HOGA1, AGXT
intracellular membrane-bounded organelle (GO:0043231) 0.62HOGA1, AGXT
extracellular vesicle (GO:1903561) 1.892GRHPR, HOGA1
peroxisomal matrix (GO:0005782) 6.02GRHPR, AGXT
vesicle (GO:0031982) 1.642GRHPR, HOGA1
organelle lumen (GO:0043233) 3.052GRHPR, AGXT
mitochondrion (GO:0005739) 2.422HOGA1, AGXT
membrane-bounded vesicle (GO:0031988) 1.712GRHPR, HOGA1
intracellular organelle part (GO:0044446) 0.812GRHPR, AGXT
intracellular organelle lumen (GO:0070013) 3.052GRHPR, AGXT
intracellular organelle (GO:0043229) 0.512HOGA1, AGXT
membrane-enclosed lumen (GO:0031974) 3.052GRHPR, AGXT
microbody lumen (GO:0031907) 6.02GRHPR, AGXT
extracellular organelle (GO:0043230) 1.892GRHPR, HOGA1
peroxisomal part (GO:0044439) 5.282GRHPR, AGXT
microbody part (GO:0044438) 5.282GRHPR, AGXT
extracellular region part (GO:0044421) 1.572GRHPR, HOGA1
organelle part (GO:0044422) 0.792GRHPR, AGXT
extracellular exosome (GO:0070062) 1.892GRHPR, HOGA1

NET-GE enrichment

Term New enriched termICP valueGenes
microbody lumen (GO:0031907) -6.00.0GRHPR, AGXT
peroxisomal part (GO:0044439) -5.280.002GRHPR, AGXT
microbody part (GO:0044438) -5.280.002GRHPR, AGXT
peroxisomal matrix (GO:0005782) -6.00.0GRHPR, AGXT