Disease table of PULMONARY VENOOCCLUSIVE DISEASE OMIM ID: PS265450

Gene-disease associations table

GeneAssociated with PULMONARY VENOOCCLUSIVE DISEASE inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
BMPR2OMIMHGNC link2q33.12PS178600, PS265450
EIF2AK4ClinVar, OMIM, HUMSAVARHGNC link15q15.11PS265450

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
BMPR2EIF2AK4No1PPP1CC

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
BMPR2EIF2AK4No-1PPP1CA

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term New enriched termICP valueGenes
Protein processing in endoplasmic reticulum (hsa04141) NEW5.350.035EIF2AK4, BMPR2
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
purine ribonucleoside triphosphate binding (GO:0035639) 2.222EIF2AK4, BMPR2
protein kinase activity (GO:0004672) 3.272EIF2AK4, BMPR2
heterocyclic compound binding (GO:1901363) 1.062EIF2AK4, BMPR2
nucleoside phosphate binding (GO:1901265) 1.962EIF2AK4, BMPR2
nucleoside binding (GO:0001882) 2.212EIF2AK4, BMPR2
nucleotide binding (GO:0000166) 1.962EIF2AK4, BMPR2
protein serine/threonine kinase activity (GO:0004674) 3.642EIF2AK4, BMPR2
transferase activity (GO:0016740) 1.952EIF2AK4, BMPR2
purine nucleoside binding (GO:0001883) 2.222EIF2AK4, BMPR2
ribonucleoside binding (GO:0032549) 2.222EIF2AK4, BMPR2
purine nucleotide binding (GO:0017076) 2.192EIF2AK4, BMPR2
ATP binding (GO:0005524) 2.432EIF2AK4, BMPR2
kinase activity (GO:0016301) 2.932EIF2AK4, BMPR2
small molecule binding (GO:0036094) 1.892EIF2AK4, BMPR2
catalytic activity (GO:0003824) 1.052EIF2AK4, BMPR2
adenyl nucleotide binding (GO:0030554) 2.42EIF2AK4, BMPR2
carbohydrate derivative binding (GO:0097367) 2.032EIF2AK4, BMPR2
organic cyclic compound binding (GO:0097159) 1.052EIF2AK4, BMPR2
phosphotransferase activity, alcohol group as acceptor (GO:0016773) 3.082EIF2AK4, BMPR2
adenyl ribonucleotide binding (GO:0032559) 2.412EIF2AK4, BMPR2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772EIF2AK4, BMPR2
purine ribonucleotide binding (GO:0032555) 2.22EIF2AK4, BMPR2
purine ribonucleoside binding (GO:0032550) 2.222EIF2AK4, BMPR2
ribonucleotide binding (GO:0032553) 2.192EIF2AK4, BMPR2
binding (GO:0005488) 0.182EIF2AK4, BMPR2

NET-GE enrichment

Term New enriched termICP valueGenes
protein serine/threonine kinase activity (GO:0004674) -3.640.034EIF2AK4, BMPR2
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of phosphate metabolic process (GO:0019220) 2.352EIF2AK4, BMPR2
regulation of primary metabolic process (GO:0080090) 1.082EIF2AK4, BMPR2
regulation of metabolic process (GO:0019222) 1.022EIF2AK4, BMPR2
positive regulation of response to stimulus (GO:0048584) 2.182EIF2AK4, BMPR2
regulation of response to stimulus (GO:0048583) 1.542EIF2AK4, BMPR2
cellular response to stimulus (GO:0051716) 1.972EIF2AK4, BMPR2
negative regulation of macromolecule metabolic process (GO:0010605) 2.012EIF2AK4, BMPR2
positive regulation of macromolecule metabolic process (GO:0010604) 1.812EIF2AK4, BMPR2
regulation of neuron differentiation (GO:0045664) 3.392EIF2AK4, BMPR2
positive regulation of biological process (GO:0048518) 1.22EIF2AK4, BMPR2
negative regulation of biological process (GO:0048519) 1.332EIF2AK4, BMPR2
regulation of macromolecule metabolic process (GO:0060255) 1.082EIF2AK4, BMPR2
regulation of RNA biosynthetic process (GO:2001141) 1.552EIF2AK4, BMPR2
system process (GO:0003008) 2.32EIF2AK4, BMPR2
regulation of phosphorylation (GO:0042325) 2.52EIF2AK4, BMPR2
cellular response to extracellular stimulus (GO:0031668) 4.572EIF2AK4, BMPR2
cellular response to nutrient levels (GO:0031669) 4.72EIF2AK4, BMPR2
response to external stimulus (GO:0009605) 2.552EIF2AK4, BMPR2
single-multicellular organism process (GO:0044707) 1.782EIF2AK4, BMPR2
protein metabolic process (GO:0019538) 1.452EIF2AK4, BMPR2
response to nutrient levels (GO:0031667) 3.772EIF2AK4, BMPR2
cellular response to stress (GO:0033554) 2.512EIF2AK4, BMPR2
negative regulation of metabolic process (GO:0009892) 1.932EIF2AK4, BMPR2
positive regulation of metabolic process (GO:0009893) 1.742EIF2AK4, BMPR2
negative regulation of biosynthetic process (GO:0009890) 2.472EIF2AK4, BMPR2
positive regulation of biosynthetic process (GO:0009891) 2.292EIF2AK4, BMPR2
metabolic process (GO:0008152) 0.582EIF2AK4, BMPR2
nitrogen compound metabolic process (GO:0006807) 1.132EIF2AK4, BMPR2
regulation of biological process (GO:0050789) 0.452EIF2AK4, BMPR2
cellular protein metabolic process (GO:0044267) 1.632EIF2AK4, BMPR2
cellular macromolecule metabolic process (GO:0044260) 0.932EIF2AK4, BMPR2
biological regulation (GO:0065007) 0.392EIF2AK4, BMPR2
regulation of biological quality (GO:0065008) 1.682EIF2AK4, BMPR2
regulation of developmental process (GO:0050793) 2.12EIF2AK4, BMPR2
regulation of biosynthetic process (GO:0009889) 1.372EIF2AK4, BMPR2
regulation of cellular process (GO:0050794) 0.52EIF2AK4, BMPR2
response to stress (GO:0006950) 1.82EIF2AK4, BMPR2
protein modification process (GO:0036211) 1.792EIF2AK4, BMPR2
cellular response to starvation (GO:0009267) 4.982EIF2AK4, BMPR2
single-organism developmental process (GO:0044767) 1.492EIF2AK4, BMPR2
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592EIF2AK4, BMPR2
response to stimulus (GO:0050896) 1.222EIF2AK4, BMPR2
macromolecule modification (GO:0043412) 1.732EIF2AK4, BMPR2
regulation of transcription, DNA-templated (GO:0006355) 1.562EIF2AK4, BMPR2
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392EIF2AK4, BMPR2
regulation of macromolecule biosynthetic process (GO:0010556) 1.432EIF2AK4, BMPR2
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532EIF2AK4, BMPR2
regulation of multicellular organismal process (GO:0051239) 1.872EIF2AK4, BMPR2
regulation of response to external stimulus (GO:0032101) 3.062EIF2AK4, BMPR2
phosphorylation (GO:0016310) 2.632EIF2AK4, BMPR2
cellular biosynthetic process (GO:0044249) 1.372EIF2AK4, BMPR2
cellular nitrogen compound metabolic process (GO:0034641) 1.222EIF2AK4, BMPR2
cellular macromolecule biosynthetic process (GO:0034645) 1.662EIF2AK4, BMPR2
regulation of signaling (GO:0023051) 1.722EIF2AK4, BMPR2
regulation of cell communication (GO:0010646) 1.732EIF2AK4, BMPR2
single-organism process (GO:0044699) 0.482EIF2AK4, BMPR2
regulation of neurogenesis (GO:0050767) 3.212EIF2AK4, BMPR2
negative regulation of multicellular organismal process (GO:0051241) 2.842EIF2AK4, BMPR2
regulation of protein metabolic process (GO:0051246) 1.932EIF2AK4, BMPR2
positive regulation of protein metabolic process (GO:0051247) 2.432EIF2AK4, BMPR2
regulation of cell development (GO:0060284) 3.012EIF2AK4, BMPR2
positive regulation of cellular protein metabolic process (GO:0032270) 2.492EIF2AK4, BMPR2
regulation of protein modification process (GO:0031399) 2.322EIF2AK4, BMPR2
developmental process (GO:0032502) 1.362EIF2AK4, BMPR2
multicellular organismal process (GO:0032501) 1.452EIF2AK4, BMPR2
cellular process (GO:0009987) 0.262EIF2AK4, BMPR2
regulation of nucleic acid-templated transcription (GO:1903506) 1.552EIF2AK4, BMPR2
regulation of cell differentiation (GO:0045595) 2.422EIF2AK4, BMPR2
regulation of cellular protein metabolic process (GO:0032268) 1.992EIF2AK4, BMPR2
regulation of RNA metabolic process (GO:0051252) 1.522EIF2AK4, BMPR2
macromolecule metabolic process (GO:0043170) 0.832EIF2AK4, BMPR2
positive regulation of gene expression (GO:0010628) 2.352EIF2AK4, BMPR2
system development (GO:0048731) 2.922EIF2AK4, BMPR2
response to extracellular stimulus (GO:0009991) 3.712EIF2AK4, BMPR2
positive regulation of cellular biosynthetic process (GO:0031328) 2.32EIF2AK4, BMPR2
negative regulation of cellular biosynthetic process (GO:0031327) 2.492EIF2AK4, BMPR2
regulation of cellular biosynthetic process (GO:0031326) 1.382EIF2AK4, BMPR2
positive regulation of cellular metabolic process (GO:0031325) 1.812EIF2AK4, BMPR2
negative regulation of cellular metabolic process (GO:0031324) 2.012EIF2AK4, BMPR2
regulation of cellular metabolic process (GO:0031323) 1.072EIF2AK4, BMPR2
cellular response to external stimulus (GO:0071496) 4.22EIF2AK4, BMPR2
response to starvation (GO:0042594) 4.692EIF2AK4, BMPR2
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462EIF2AK4, BMPR2
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62EIF2AK4, BMPR2
organic substance metabolic process (GO:0071704) 0.632EIF2AK4, BMPR2
regulation of nervous system development (GO:0051960) 3.12EIF2AK4, BMPR2
regulation of gene expression (GO:0010468) 1.372EIF2AK4, BMPR2
protein phosphorylation (GO:0006468) 2.892EIF2AK4, BMPR2
organic substance biosynthetic process (GO:1901576) 1.342EIF2AK4, BMPR2
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432EIF2AK4, BMPR2
cellular protein modification process (GO:0006464) 1.792EIF2AK4, BMPR2
regulation of phosphorus metabolic process (GO:0051174) 2.352EIF2AK4, BMPR2
biosynthetic process (GO:0009058) 1.322EIF2AK4, BMPR2
macromolecule biosynthetic process (GO:0009059) 1.612EIF2AK4, BMPR2
single-organism cellular process (GO:0044763) 0.652EIF2AK4, BMPR2
regulation of nitrogen compound metabolic process (GO:0051171) 1.362EIF2AK4, BMPR2
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472EIF2AK4, BMPR2
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292EIF2AK4, BMPR2
cell communication (GO:0007154) 3.042EIF2AK4, BMPR2
primary metabolic process (GO:0044238) 0.692EIF2AK4, BMPR2
anatomical structure development (GO:0048856) 1.582EIF2AK4, BMPR2
cellular metabolic process (GO:0044237) 0.692EIF2AK4, BMPR2
phosphate-containing compound metabolic process (GO:0006796) 2.162EIF2AK4, BMPR2
regulation of multicellular organismal development (GO:2000026) 2.312EIF2AK4, BMPR2
phosphorus metabolic process (GO:0006793) 2.152EIF2AK4, BMPR2
regulation of protein phosphorylation (GO:0001932) 2.572EIF2AK4, BMPR2
negative regulation of cellular process (GO:0048523) 1.412EIF2AK4, BMPR2
positive regulation of cellular process (GO:0048522) 1.32EIF2AK4, BMPR2

NET-GE enrichment

Term New enriched termICP valueGenes
cellular response to extracellular stimulus (GO:0031668) -4.570.01EIF2AK4, BMPR2
cellular response to external stimulus (GO:0071496) -4.20.025EIF2AK4, BMPR2
response to starvation (GO:0042594) -4.690.008EIF2AK4, BMPR2
cellular response to nutrient levels (GO:0031669) -4.70.007EIF2AK4, BMPR2
cellular response to starvation (GO:0009267) -4.980.004EIF2AK4, BMPR2
GO - cellular component annotation: shared terms (no NET-GE enrichment)

Shared terms

GOICNumber of genes with the same GOGenes
cytoplasm (GO:0005737) 1.012EIF2AK4, BMPR2
intracellular part (GO:0044424) 0.282EIF2AK4, BMPR2
cell part (GO:0044464) 0.112EIF2AK4, BMPR2