Disease table of PULMONARY HYPERTENSION, PRIMARY OMIM ID: PS178600

Gene-disease associations table

GeneAssociated with PULMONARY HYPERTENSION, PRIMARY inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
KCNA5ClinVarHGNC link12p13.322PS178600, PS608583
BMPR2ClinVar, OMIM, HUMSAVARHGNC link2q33.12PS178600, PS265450
KCNK3ClinVar, OMIM, HUMSAVARHGNC link2p23.31PS178600
SMAD9ClinVar, OMIM, HUMSAVARHGNC link13q13.32209920, PS178600
CAV1OMIMHGNC link7q31.23606721, PS178600, PS608594

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
22BMPR2, KCNK3
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CAV1YES6SP1, GATA6, SREBF1, TFDP1, TP53, PPARG0
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
KCNA5BMPR2No1CAV1
KCNA5CAV1Yes6KCNA5, TFRC, HSP90AA1, SRC, FYN, KCNA3
BMPR2SMAD9No1SMAD7
BMPR2CAV1Yes3BMPR2, BMPR1A, TGFBR1
SMAD9CAV1No2ACTB, SMAD2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
KCNA5CAV1No-2SRC, FYN
BMPR2SMAD9Yesactivation, binding21SMURF1, BMPR1B, ACVRL1, BMP4, ACVR2B, PPP1CA, SMAD7, BMPR1A, ACVR2A, SMAD1, ZFYVE16, TGFBR1, SMAD6, BMP2, BMP7, SMAD5, RGMA, ACVR1B, AMH, ACVR1, RGMB
BMPR2CAV1No-12SMURF1, ACVRL1, FKBP1A, SMAD7, NOS3, PPP1CA, SMAD1, SMAD5, TGFBR1, SMAD2, BMPR1A, SMAD9
SMAD9CAV1Yesactivation12MAPK3, SMURF1, TGFBR2, MAPK1, SMAD7, SMAD1, PPP1CA, SMAD5, TGFBR1, ACVRL1, TGFB1, BMPR1A

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
TGF-beta signaling pathwayhsa043506.412SMAD9, BMPR2
Signaling pathways regulating pluripotency of stem cellshsa045505.62SMAD9, BMPR2

NET-GE enrichment

Term New enriched termICP valueGenes
TGF-beta signaling pathway (hsa04350) -6.410.002SMAD9, BMPR2, CAV1
Signaling pathways regulating pluripotency of stem cells (hsa04550) -5.60.026SMAD9, BMPR2, CAV1
Cellular communityNEW3.570.012SMAD9, BMPR2, CAV1
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
Signal TransductionR-HSA-1625821.783SMAD9, BMPR2, CAV1
Neuronal SystemR-HSA-1123164.822KCNK3, KCNA5
Signaling by BMPR-HSA-2014518.462SMAD9, BMPR2
Potassium ChannelsR-HSA-12960716.352KCNK3, KCNA5

NET-GE enrichment

Term New enriched termICP valueGenes
Netrin-1 signaling (R-HSA-373752) NEW7.590.023BMPR2, CAV1
Signaling by BMP (R-HSA-201451) -8.460.002SMAD9, BMPR2
Potassium Channels (R-HSA-1296071) -6.350.036KCNK3, KCNA5
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.185SMAD9, KCNK3, BMPR2, KCNA5, CAV1
protein binding (GO:0005515) 0.465SMAD9, KCNK3, BMPR2, KCNA5, CAV1
organic cyclic compound binding (GO:0097159) 1.053SMAD9, BMPR2, CAV1
potassium channel activity (GO:0005267) 4.942KCNK3, KCNA5
cation channel activity (GO:0005261) 4.042KCNK3, KCNA5
enzyme binding (GO:0019899) 2.272CAV1, KCNA5
small molecule binding (GO:0036094) 1.892BMPR2, CAV1
signal transducer activity (GO:0004871) 2.282SMAD9, BMPR2
molecular function regulator (GO:0098772) 2.512CAV1, KCNA5
heterocyclic compound binding (GO:1901363) 1.062SMAD9, BMPR2
cation binding (GO:0043169) 1.42SMAD9, BMPR2
receptor signaling protein activity (GO:0005057) 4.762SMAD9, BMPR2
transmembrane transporter activity (GO:0022857) 2.822KCNK3, KCNA5
ion binding (GO:0043167) 1.362SMAD9, BMPR2
substrate-specific channel activity (GO:0022838) 3.672KCNK3, KCNA5
channel inhibitor activity (GO:0016248) 6.132CAV1, KCNA5
channel regulator activity (GO:0016247) 4.882CAV1, KCNA5
passive transmembrane transporter activity (GO:0022803) 3.62KCNK3, KCNA5
metal ion transmembrane transporter activity (GO:0046873) 3.712KCNK3, KCNA5
metal ion binding (GO:0046872) 1.412SMAD9, BMPR2
potassium channel regulator activity (GO:0015459) 5.932CAV1, KCNA5
identical protein binding (GO:0042802) 2.632CAV1, KCNK3
voltage-gated cation channel activity (GO:0022843) 4.832KCNK3, KCNA5
protein heterodimerization activity (GO:0046982) 3.642CAV1, KCNK3
transporter activity (GO:0005215) 2.572KCNK3, KCNA5
ion channel activity (GO:0005216) 3.712KCNK3, KCNA5
cation transmembrane transporter activity (GO:0008324) 3.322KCNK3, KCNA5
protein kinase binding (GO:0019901) 3.442CAV1, KCNA5
kinase binding (GO:0019900) 3.322CAV1, KCNA5
ion channel inhibitor activity (GO:0008200) 6.152CAV1, KCNA5
protein dimerization activity (GO:0046983) 2.722CAV1, KCNK3
substrate-specific transmembrane transporter activity (GO:0022891) 2.92KCNK3, KCNA5
inorganic cation transmembrane transporter activity (GO:0022890) 3.492KCNK3, KCNA5
substrate-specific transporter activity (GO:0022892) 2.722KCNK3, KCNA5
ion transmembrane transporter activity (GO:0015075) 3.042KCNK3, KCNA5
voltage-gated channel activity (GO:0022832) 4.492KCNK3, KCNA5
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.872KCNK3, KCNA5
channel activity (GO:0015267) 3.62KCNK3, KCNA5
gated channel activity (GO:0022836) 3.962KCNK3, KCNA5
voltage-gated potassium channel activity (GO:0005249) 5.242KCNK3, KCNA5
potassium channel inhibitor activity (GO:0019870) 7.662CAV1, KCNA5
receptor binding (GO:0005102) 2.432CAV1, KCNA5
voltage-gated ion channel activity (GO:0005244) 4.492KCNK3, KCNA5
potassium ion transmembrane transporter activity (GO:0015079) 4.772KCNK3, KCNA5

NET-GE enrichment

Term New enriched termICP valueGenes
potassium channel activity (GO:0005267) -4.940.048KCNK3, KCNA5
potassium channel inhibitor activity (GO:0019870) -7.660.001CAV1, KCNA5
voltage-gated cation channel activity (GO:0022843) -4.830.011KCNK3, CAV1, KCNA5
passive transmembrane transporter activity (GO:0022803) -3.60.01KCNK3, BMPR2, KCNA5, CAV1
protein homodimerization activity (GO:0042803) NEW3.160.007SMAD9, KCNK3, CAV1, KCNA5, BMPR2
transporter activity (GO:0005215) -2.570.023SMAD9, KCNK3, CAV1, KCNA5, BMPR2
ion channel activity (GO:0005216) -3.710.007KCNK3, CAV1, KCNA5, BMPR2
cation transmembrane transporter activity (GO:0008324) -3.320.001SMAD9, KCNK3, CAV1, KCNA5, BMPR2
metal ion transmembrane transporter activity (GO:0046873) -3.710.0SMAD9, KCNK3, CAV1, KCNA5, BMPR2
cell adhesion molecule binding (GO:0050839) NEW4.50.036BMPR2, KCNA5, CAV1
substrate-specific transmembrane transporter activity (GO:0022891) -2.90.004SMAD9, KCNK3, BMPR2, KCNA5, CAV1
inorganic cation transmembrane transporter activity (GO:0022890) -3.490.0SMAD9, KCNA5, BMPR2, KCNK3, CAV1
substrate-specific transporter activity (GO:0022892) -2.720.008SMAD9, KCNK3, CAV1, KCNA5, BMPR2
voltage-gated ion channel activity (GO:0005244) -4.490.021KCNK3, CAV1, KCNA5
ion transmembrane transporter activity (GO:0015075) -3.040.002SMAD9, KCNK3, BMPR2, KCNA5, CAV1
voltage-gated channel activity (GO:0022832) -4.490.021KCNK3, CAV1, KCNA5
transmembrane transporter activity (GO:0022857) -2.820.005SMAD9, KCNA5, BMPR2, KCNK3, CAV1
channel activity (GO:0015267) -3.60.01KCNK3, CAV1, KCNA5, BMPR2
gated channel activity (GO:0022836) -3.960.003KCNK3, CAV1, KCNA5, BMPR2
voltage-gated potassium channel activity (GO:0005249) -5.240.024KCNK3, KCNA5
receptor signaling protein activity (GO:0005057) -4.760.013SMAD9, BMPR2, CAV1
protein dimerization activity (GO:0046983) -2.720.05SMAD9, KCNK3, CAV1, KCNA5, BMPR2
substrate-specific channel activity (GO:0022838) -3.670.008KCNK3, BMPR2, KCNA5, CAV1
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
response to stimulus (GO:0050896) 1.225SMAD9, KCNA5, BMPR2, KCNK3, CAV1
cellular process (GO:0009987) 0.265SMAD9, KCNA5, BMPR2, KCNK3, CAV1
biological regulation (GO:0065007) 0.395SMAD9, KCNK3, CAV1, KCNA5, BMPR2
response to chemical (GO:0042221) 1.985SMAD9, KCNA5, BMPR2, KCNK3, CAV1
regulation of biological process (GO:0050789) 0.455SMAD9, KCNA5, BMPR2, KCNK3, CAV1
single-organism process (GO:0044699) 0.485SMAD9, KCNK3, CAV1, KCNA5, BMPR2
developmental process (GO:0032502) 1.364SMAD9, CAV1, KCNK3, BMPR2
cellular response to stimulus (GO:0051716) 1.974SMAD9, CAV1, KCNK3, BMPR2
single-multicellular organism process (GO:0044707) 1.784KCNK3, CAV1, KCNA5, BMPR2
cellular response to chemical stimulus (GO:0070887) 2.574SMAD9, CAV1, KCNK3, BMPR2
regulation of system process (GO:0044057) 3.534KCNK3, CAV1, KCNA5, BMPR2
multicellular organismal process (GO:0032501) 1.454KCNK3, CAV1, KCNA5, BMPR2
anatomical structure development (GO:0048856) 1.584SMAD9, BMPR2, KCNK3, CAV1
regulation of cellular process (GO:0050794) 0.54SMAD9, BMPR2, KCNA5, CAV1
single-organism developmental process (GO:0044767) 1.494SMAD9, CAV1, KCNK3, BMPR2
response to stress (GO:0006950) 1.84KCNK3, CAV1, KCNA5, BMPR2
animal organ development (GO:0048513) 2.534SMAD9, CAV1, KCNK3, BMPR2
single-organism cellular process (GO:0044763) 0.654KCNK3, BMPR2, KCNA5, CAV1
signal transduction (GO:0007165) 1.284SMAD9, BMPR2, KCNA5, CAV1
regulation of multicellular organismal process (GO:0051239) 1.874KCNK3, CAV1, KCNA5, BMPR2
positive regulation of biological process (GO:0048518) 1.24SMAD9, BMPR2, KCNA5, CAV1
regulation of blood circulation (GO:1903522) 4.054KCNK3, CAV1, KCNA5, BMPR2
regulation of biological quality (GO:0065008) 1.684KCNK3, BMPR2, KCNA5, CAV1
response to organic substance (GO:0010033) 2.24SMAD9, BMPR2, KCNA5, CAV1
positive regulation of cellular process (GO:0048522) 1.34SMAD9, BMPR2, KCNA5, CAV1
regulation of primary metabolic process (GO:0080090) 1.083SMAD9, BMPR2, CAV1
regulation of metabolic process (GO:0019222) 1.023SMAD9, BMPR2, CAV1
regulation of vasoconstriction (GO:0019229) 5.513BMPR2, KCNA5, CAV1
circulatory system process (GO:0003013) 4.383BMPR2, KCNA5, CAV1
calcium ion homeostasis (GO:0055074) 3.973KCNK3, CAV1, KCNA5
cell surface receptor signaling pathway (GO:0007166) 2.093SMAD9, BMPR2, KCNA5
vascular process in circulatory system (GO:0003018) 4.653BMPR2, KCNA5, CAV1
cellular component organization or biogenesis (GO:0071840) 1.223KCNK3, CAV1, KCNA5
positive regulation of macromolecule metabolic process (GO:0010604) 1.813SMAD9, BMPR2, CAV1
response to growth factor (GO:0070848) 4.143SMAD9, BMPR2, CAV1
negative regulation of biological process (GO:0048519) 1.333BMPR2, KCNA5, CAV1
regulation of cell proliferation (GO:0042127) 2.413BMPR2, KCNA5, CAV1
regulation of macromolecule metabolic process (GO:0060255) 1.083SMAD9, BMPR2, CAV1
regulation of RNA biosynthetic process (GO:2001141) 1.553SMAD9, BMPR2, CAV1
response to inorganic substance (GO:0010035) 3.563KCNK3, CAV1, KCNA5
system process (GO:0003008) 2.33BMPR2, KCNA5, CAV1
single organism signaling (GO:0044700) 3.253KCNK3, CAV1, KCNA5
response to external stimulus (GO:0009605) 2.553BMPR2, KCNA5, CAV1
protein metabolic process (GO:0019538) 1.453SMAD9, BMPR2, CAV1
chemical homeostasis (GO:0048878) 2.973KCNK3, CAV1, KCNA5
cellular response to stress (GO:0033554) 2.513CAV1, KCNK3, BMPR2
regulation of membrane potential (GO:0042391) 3.893KCNK3, CAV1, KCNA5
positive regulation of metabolic process (GO:0009893) 1.743SMAD9, BMPR2, CAV1
inorganic ion homeostasis (GO:0098771) 3.433KCNK3, CAV1, KCNA5
positive regulation of gene expression (GO:0010628) 2.353SMAD9, BMPR2, CAV1
cellular protein metabolic process (GO:0044267) 1.633SMAD9, BMPR2, CAV1
regulation of cell communication (GO:0010646) 1.733BMPR2, KCNA5, CAV1
cellular macromolecule metabolic process (GO:0044260) 0.933SMAD9, BMPR2, CAV1
cellular component organization (GO:0016043) 1.243KCNK3, CAV1, KCNA5
regulation of anatomical structure size (GO:0090066) 3.783BMPR2, KCNA5, CAV1
regulation of tube size (GO:0035150) 4.793BMPR2, KCNA5, CAV1
transport (GO:0006810) 1.513KCNK3, CAV1, KCNA5
cation transport (GO:0006812) 3.113KCNK3, CAV1, KCNA5
ion transport (GO:0006811) 2.663KCNK3, CAV1, KCNA5
regulation of heart contraction (GO:0008016) 4.353KCNK3, CAV1, KCNA5
regulation of biosynthetic process (GO:0009889) 1.373SMAD9, BMPR2, CAV1
macromolecule modification (GO:0043412) 1.733SMAD9, BMPR2, CAV1
protein modification process (GO:0036211) 1.793SMAD9, BMPR2, CAV1
metabolic process (GO:0008152) 0.583SMAD9, BMPR2, CAV1
establishment of localization (GO:0051234) 1.483KCNK3, CAV1, KCNA5
response to decreased oxygen levels (GO:0036293) 4.093KCNK3, CAV1, KCNA5
regulation of transcription, DNA-templated (GO:0006355) 1.563SMAD9, BMPR2, CAV1
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.243SMAD9, BMPR2, CAV1
regulation of nitrogen compound metabolic process (GO:0051171) 1.363SMAD9, BMPR2, CAV1
multicellular organismal signaling (GO:0035637) 5.363KCNK3, CAV1, KCNA5
phosphorylation (GO:0016310) 2.633SMAD9, BMPR2, CAV1
ion homeostasis (GO:0050801) 3.423KCNK3, CAV1, KCNA5
signaling (GO:0023052) 3.253KCNK3, CAV1, KCNA5
regulation of signaling (GO:0023051) 1.723BMPR2, KCNA5, CAV1
response to hypoxia (GO:0001666) 4.133KCNK3, CAV1, KCNA5
response to endogenous stimulus (GO:0009719) 2.793SMAD9, BMPR2, CAV1
divalent inorganic cation homeostasis (GO:0072507) 3.93KCNK3, CAV1, KCNA5
regulation of blood vessel size (GO:0050880) 4.83BMPR2, KCNA5, CAV1
cellular divalent inorganic cation homeostasis (GO:0072503) 3.963KCNK3, CAV1, KCNA5
positive regulation of cell proliferation (GO:0008284) 3.013BMPR2, KCNA5, CAV1
response to abiotic stimulus (GO:0009628) 2.83KCNK3, CAV1, KCNA5
cellular metal ion homeostasis (GO:0006875) 3.753KCNK3, CAV1, KCNA5
cellular calcium ion homeostasis (GO:0006874) 4.013KCNK3, CAV1, KCNA5
cellular ion homeostasis (GO:0006873) 3.573KCNK3, CAV1, KCNA5
metal ion transport (GO:0030001) 3.363KCNK3, CAV1, KCNA5
cellular cation homeostasis (GO:0030003) 3.63KCNK3, CAV1, KCNA5
cation homeostasis (GO:0055080) 3.463KCNK3, CAV1, KCNA5
cellular chemical homeostasis (GO:0055082) 3.43KCNK3, CAV1, KCNA5
regulation of localization (GO:0032879) 1.943BMPR2, KCNA5, CAV1
cellular response to growth factor stimulus (GO:0071363) 4.273SMAD9, BMPR2, CAV1
regulation of RNA metabolic process (GO:0051252) 1.523SMAD9, BMPR2, CAV1
macromolecule metabolic process (GO:0043170) 0.833SMAD9, BMPR2, CAV1
cellular homeostasis (GO:0019725) 3.233KCNK3, CAV1, KCNA5
regulation of cellular biosynthetic process (GO:0031326) 1.383SMAD9, BMPR2, CAV1
positive regulation of cellular metabolic process (GO:0031325) 1.813SMAD9, BMPR2, CAV1
regulation of cellular metabolic process (GO:0031323) 1.073SMAD9, BMPR2, CAV1
homeostatic process (GO:0042592) 2.613KCNK3, CAV1, KCNA5
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.463SMAD9, BMPR2, CAV1
organic substance metabolic process (GO:0071704) 0.633SMAD9, BMPR2, CAV1
cellular response to organic substance (GO:0071310) 2.783SMAD9, BMPR2, CAV1
regulation of macromolecule biosynthetic process (GO:0010556) 1.433SMAD9, BMPR2, CAV1
regulation of gene expression (GO:0010468) 1.373SMAD9, BMPR2, CAV1
protein phosphorylation (GO:0006468) 2.893SMAD9, BMPR2, CAV1
cardiac conduction (GO:0061337) 5.543KCNK3, CAV1, KCNA5
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.433SMAD9, BMPR2, CAV1
cellular protein modification process (GO:0006464) 1.793SMAD9, BMPR2, CAV1
single-organism transport (GO:0044765) 2.183KCNK3, CAV1, KCNA5
regulation of nucleic acid-templated transcription (GO:1903506) 1.553SMAD9, BMPR2, CAV1
metal ion homeostasis (GO:0055065) 3.613KCNK3, CAV1, KCNA5
cell communication (GO:0007154) 3.043BMPR2, KCNK3, CAV1
localization (GO:0051179) 1.43KCNK3, CAV1, KCNA5
single-organism localization (GO:1902578) 2.093KCNK3, CAV1, KCNA5
response to oxygen levels (GO:0070482) 4.023KCNK3, CAV1, KCNA5
primary metabolic process (GO:0044238) 0.693SMAD9, BMPR2, CAV1
regulation of cytosolic calcium ion concentration (GO:0051480) 4.413KCNK3, CAV1, KCNA5
cellular metabolic process (GO:0044237) 0.693SMAD9, BMPR2, CAV1
cellular response to endogenous stimulus (GO:0071495) 3.333SMAD9, BMPR2, CAV1
phosphate-containing compound metabolic process (GO:0006796) 2.163SMAD9, BMPR2, CAV1
phosphorus metabolic process (GO:0006793) 2.153SMAD9, BMPR2, CAV1
regulation of phosphate metabolic process (GO:0019220) 2.352BMPR2, CAV1
regulation of transport (GO:0051049) 2.242CAV1, KCNA5
positive regulation of response to stimulus (GO:0048584) 2.182BMPR2, CAV1
regulation of response to stimulus (GO:0048583) 1.542BMPR2, CAV1
tissue remodeling (GO:0048771) 5.542BMPR2, CAV1
BMP signaling pathway (GO:0030509) 5.332SMAD9, BMPR2
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242SMAD9, BMPR2
regulation of ion transmembrane transport (GO:0034765) 3.772CAV1, KCNA5
organic cyclic compound biosynthetic process (GO:1901362) 1.662SMAD9, BMPR2
regulation of cell projection organization (GO:0031344) 3.382BMPR2, CAV1
organic cyclic compound metabolic process (GO:1901360) 1.262SMAD9, BMPR2
single-organism metabolic process (GO:0044710) 1.632BMPR2, CAV1
negative regulation of macromolecule metabolic process (GO:0010605) 2.012BMPR2, CAV1
regulation of signal transduction (GO:0009966) 1.842BMPR2, CAV1
positive regulation of signal transduction (GO:0009967) 2.52BMPR2, CAV1
response to mechanical stimulus (GO:0009612) 4.412CAV1, KCNA5
regulation of neuron differentiation (GO:0045664) 3.392BMPR2, CAV1
regulation of BMP signaling pathway (GO:0030510) 5.362BMPR2, CAV1
inorganic cation transmembrane transport (GO:0098662) 3.552KCNK3, KCNA5
negative regulation of transport (GO:0051051) 3.62CAV1, KCNA5
cellular response to extracellular stimulus (GO:0031668) 4.572BMPR2, CAV1
response to metal ion (GO:0010038) 3.912CAV1, KCNK3
transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0007178) 4.62SMAD9, BMPR2
regulation of phosphorylation (GO:0042325) 2.52BMPR2, CAV1
positive regulation of phosphorylation (GO:0042327) 2.92BMPR2, CAV1
cellular response to nutrient levels (GO:0031669) 4.72BMPR2, CAV1
response to nutrient levels (GO:0031667) 3.772BMPR2, CAV1
aromatic compound biosynthetic process (GO:0019438) 1.72SMAD9, BMPR2
cellular component assembly (GO:0022607) 2.142CAV1, KCNA5
negative regulation of metabolic process (GO:0009892) 1.932BMPR2, CAV1
negative regulation of biosynthetic process (GO:0009890) 2.472BMPR2, CAV1
positive regulation of biosynthetic process (GO:0009891) 2.292SMAD9, BMPR2
nitrogen compound metabolic process (GO:0006807) 1.132SMAD9, BMPR2
nucleic acid-templated transcription (GO:0097659) 1.912SMAD9, BMPR2
organic substance biosynthetic process (GO:1901576) 1.342SMAD9, BMPR2
heterocycle metabolic process (GO:0046483) 1.312SMAD9, BMPR2
macromolecular complex assembly (GO:0065003) 2.552CAV1, KCNA5
regulation of developmental process (GO:0050793) 2.12BMPR2, CAV1
cellular response to oxygen levels (GO:0071453) 4.972CAV1, KCNK3
signal transduction by protein phosphorylation (GO:0023014) 3.792BMPR2, CAV1
inorganic ion transmembrane transport (GO:0098660) 3.382KCNK3, KCNA5
anatomical structure formation involved in morphogenesis (GO:0048646) 3.012BMPR2, CAV1
heterocycle biosynthetic process (GO:0018130) 1.72SMAD9, BMPR2
positive regulation of cellular component organization (GO:0051130) 2.682BMPR2, CAV1
nucleobase-containing compound metabolic process (GO:0006139) 1.352SMAD9, BMPR2
potassium ion transport (GO:0006813) 4.682KCNK3, KCNA5
tissue development (GO:0009888) 3.272SMAD9, CAV1
cellular response to starvation (GO:0009267) 4.982BMPR2, CAV1
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722SMAD9, BMPR2
RNA metabolic process (GO:0016070) 1.592SMAD9, BMPR2
regulation of phosphorus metabolic process (GO:0051174) 2.352BMPR2, CAV1
cellular nitrogen compound biosynthetic process (GO:0044271) 1.592SMAD9, BMPR2
brain development (GO:0007420) 4.242BMPR2, KCNK3
positive regulation of protein modification process (GO:0031401) 2.72BMPR2, CAV1
response to increased oxygen levels (GO:0036296) 6.42CAV1, KCNA5
positive regulation of macromolecule biosynthetic process (GO:0010557) 2.392SMAD9, BMPR2
regulation of nervous system development (GO:0051960) 3.12BMPR2, CAV1
transcription, DNA-templated (GO:0006351) 1.912SMAD9, BMPR2
cellular developmental process (GO:0048869) 1.822BMPR2, CAV1
positive regulation of multicellular organismal process (GO:0051240) 2.492BMPR2, CAV1
response to BMP (GO:0071772) 6.172SMAD9, BMPR2
cellular response to BMP stimulus (GO:0071773) 6.172SMAD9, BMPR2
RNA biosynthetic process (GO:0032774) 1.842SMAD9, BMPR2
regulation of response to external stimulus (GO:0032101) 3.062BMPR2, CAV1
cell differentiation (GO:0030154) 2.142BMPR2, CAV1
regulation of cellular component organization (GO:0051128) 2.012BMPR2, CAV1
positive regulation of signaling (GO:0023056) 2.412BMPR2, CAV1
cellular biosynthetic process (GO:0044249) 1.372SMAD9, BMPR2
cellular nitrogen compound metabolic process (GO:0034641) 1.222SMAD9, BMPR2
cellular macromolecule biosynthetic process (GO:0034645) 1.662SMAD9, BMPR2
positive regulation of cell communication (GO:0010647) 2.412BMPR2, CAV1
response to organic cyclic compound (GO:0014070) 3.072SMAD9, CAV1
regulation of neurogenesis (GO:0050767) 3.212BMPR2, CAV1
regulation of cellular response to growth factor stimulus (GO:0090287) 4.292BMPR2, CAV1
cellular potassium ion transport (GO:0071804) 4.792KCNK3, KCNA5
potassium ion transmembrane transport (GO:0071805) 4.792KCNK3, KCNA5
positive regulation of phosphorus metabolic process (GO:0010562) 2.782BMPR2, CAV1
negative regulation of multicellular organismal process (GO:0051241) 2.842BMPR2, CAV1
regulation of protein metabolic process (GO:0051246) 1.932BMPR2, CAV1
positive regulation of protein metabolic process (GO:0051247) 2.432BMPR2, CAV1
regulation of cell development (GO:0060284) 3.012BMPR2, CAV1
regulation of heart rate (GO:0002027) 5.292CAV1, KCNA5
positive regulation of cellular protein metabolic process (GO:0032270) 2.492BMPR2, CAV1
regulation of protein modification process (GO:0031399) 2.322BMPR2, CAV1
monovalent inorganic cation transport (GO:0015672) 3.742KCNK3, KCNA5
positive regulation of nucleic acid-templated transcription (GO:1903508) 2.562SMAD9, BMPR2
negative regulation of cell proliferation (GO:0008285) 3.262BMPR2, CAV1
cellular response to external stimulus (GO:0071496) 4.22BMPR2, CAV1
cellular aromatic compound metabolic process (GO:0006725) 1.32SMAD9, BMPR2
negative regulation of ion transport (GO:0043271) 4.942CAV1, KCNA5
regulation of cell differentiation (GO:0045595) 2.422BMPR2, CAV1
positive regulation of transcription, DNA-templated (GO:0045893) 2.562SMAD9, BMPR2
transmembrane transport (GO:0055085) 2.722KCNK3, KCNA5
protein oligomerization (GO:0051259) 3.712CAV1, KCNA5
nucleic acid metabolic process (GO:0090304) 1.462SMAD9, BMPR2
regulation of cellular protein metabolic process (GO:0032268) 1.992BMPR2, CAV1
regulation of epithelial cell proliferation (GO:0050678) 4.062BMPR2, CAV1
positive regulation of epithelial cell proliferation (GO:0050679) 4.672BMPR2, CAV1
cellular response to organic cyclic compound (GO:0071407) 3.932SMAD9, CAV1
response to drug (GO:0042493) 3.712CAV1, KCNK3
positive regulation of RNA metabolic process (GO:0051254) 2.512SMAD9, BMPR2
regulation of protein phosphorylation (GO:0001932) 2.572BMPR2, CAV1
positive regulation of RNA biosynthetic process (GO:1902680) 2.542SMAD9, BMPR2
regulation of heart rate by cardiac conduction (GO:0086091) 6.332CAV1, KCNA5
positive regulation of transcription from RNA polymerase II promoter (GO:0045944) 2.812SMAD9, BMPR2
regulation of transmembrane transport (GO:0034762) 3.742CAV1, KCNA5
response to extracellular stimulus (GO:0009991) 3.712BMPR2, CAV1
positive regulation of cellular biosynthetic process (GO:0031328) 2.32SMAD9, BMPR2
macromolecular complex subunit organization (GO:0043933) 2.142CAV1, KCNA5
negative regulation of cellular metabolic process (GO:0031324) 2.012BMPR2, CAV1
negative regulation of potassium ion transport (GO:0043267) 6.262CAV1, KCNA5
regulation of potassium ion transport (GO:0043266) 5.312CAV1, KCNA5
response to starvation (GO:0042594) 4.692BMPR2, CAV1
response to hyperoxia (GO:0055093) 6.42CAV1, KCNA5
regulation of ion transport (GO:0043269) 3.42CAV1, KCNA5
protein complex subunit organization (GO:0071822) 2.62CAV1, KCNA5
protein homooligomerization (GO:0051260) 4.212CAV1, KCNA5
negative regulation of cellular macromolecule biosynthetic process (GO:2000113) 2.62BMPR2, CAV1
negative regulation of cellular biosynthetic process (GO:0031327) 2.492BMPR2, CAV1
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090092) 4.392BMPR2, CAV1
positive regulation of nucleobase-containing compound metabolic process (GO:0045935) 2.352SMAD9, BMPR2
negative regulation of nucleobase-containing compound metabolic process (GO:0045934) 2.552BMPR2, CAV1
positive regulation of phosphate metabolic process (GO:0045937) 2.782BMPR2, CAV1
protein complex assembly (GO:0006461) 2.782CAV1, KCNA5
regulation of metal ion transport (GO:0010959) 3.942CAV1, KCNA5
ion transmembrane transport (GO:0034220) 3.082KCNK3, KCNA5
biosynthetic process (GO:0009058) 1.322SMAD9, BMPR2
macromolecule biosynthetic process (GO:0009059) 1.612SMAD9, BMPR2
cellular component disassembly (GO:0022411) 3.522CAV1, KCNK3
negative regulation of nitrogen compound metabolic process (GO:0051172) 2.472BMPR2, CAV1
positive regulation of nitrogen compound metabolic process (GO:0051173) 2.292SMAD9, BMPR2
response to oxygen-containing compound (GO:1901700) 2.572CAV1, KCNA5
regulation of cellular component movement (GO:0051270) 3.082BMPR2, CAV1
organelle organization (GO:0006996) 2.022CAV1, KCNK3
negative regulation of cytosolic calcium ion concentration (GO:0051481) 7.332KCNK3, KCNA5
negative regulation of macromolecule biosynthetic process (GO:0010558) 2.532BMPR2, CAV1
positive regulation of endothelial cell proliferation (GO:0001938) 5.512BMPR2, CAV1
single-organism organelle organization (GO:1902589) 2.682CAV1, KCNK3
regulation of multicellular organismal development (GO:2000026) 2.312BMPR2, CAV1
cation transmembrane transport (GO:0098655) 3.432KCNK3, KCNA5
positive regulation of protein phosphorylation (GO:0001934) 2.952BMPR2, CAV1
negative regulation of cellular process (GO:0048523) 1.412BMPR2, CAV1
regulation of endothelial cell proliferation (GO:0001936) 5.142BMPR2, CAV1

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of vasoconstriction (GO:0045906) NEW7.530.001BMPR2, CAV1
negative regulation of cell growth (GO:0030308) NEW4.580.004SMAD9, BMPR2, KCNA5, CAV1
ion homeostasis (GO:0050801) -3.420.003SMAD9, KCNK3, BMPR2, KCNA5, CAV1
regulation of vasoconstriction (GO:0019229) -5.510.0BMPR2, KCNA5, CAV1
BMP signaling pathway (GO:0030509) -5.330.007SMAD9, BMPR2, CAV1
signaling (GO:0023052) -3.250.029SMAD9, KCNK3, CAV1, KCNA5, BMPR2
calcium ion homeostasis (GO:0055074) -3.970.02KCNK3, CAV1, KCNA5
regulation of ion transmembrane transport (GO:0034765) -3.770.026KCNK3, CAV1, KCNA5, BMPR2
response to hypoxia (GO:0001666) -4.130.0SMAD9, KCNK3, CAV1, KCNA5, BMPR2
signal transduction by phosphorylation (GO:0023014) -3.790.005SMAD9, BMPR2, KCNA5, CAV1
divalent inorganic cation homeostasis (GO:0072507) -3.90.023KCNK3, CAV1, KCNA5
cellular divalent inorganic cation homeostasis (GO:0072503) -3.960.019KCNK3, CAV1, KCNA5
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:0090100) NEW5.120.013SMAD9, BMPR2, CAV1
organ development (GO:0048513) -2.530.044SMAD9, CAV1, KCNK3, BMPR2
regulation of transmembrane transport (GO:0034762) -3.740.035KCNK3, CAV1, KCNA5, BMPR2
cation transport (GO:0006812) -3.110.018SMAD9, KCNK3, CAV1, KCNA5, BMPR2
regulation of BMP signaling pathway (GO:0030510) -5.360.017SMAD9, BMPR2, CAV1
single organism signaling (GO:0044700) -3.250.029SMAD9, KCNK3, CAV1, KCNA5, BMPR2
cellular metal ion homeostasis (GO:0006875) -3.750.047KCNK3, BMPR2, KCNA5, CAV1
cellular calcium ion homeostasis (GO:0006874) -4.010.017KCNK3, CAV1, KCNA5
vasculogenesis (GO:0001570) NEW5.650.016SMAD9, BMPR2, CAV1
metal ion transport (GO:0030001) -3.360.004SMAD9, KCNK3, BMPR2, KCNA5, CAV1
metal ion homeostasis (GO:0055065) -3.610.001SMAD9, KCNA5, BMPR2, KCNK3, CAV1
cation homeostasis (GO:0055080) -3.460.002SMAD9, KCNA5, BMPR2, KCNK3, CAV1
cell communication (GO:0007154) -3.040.014KCNK3, BMPR2, KCNA5, CAV1
retina vasculature development in camera-type eye (GO:0061298) NEW7.650.005BMPR2, CAV1
response to oxygen levels (GO:0070482) -4.020.0SMAD9, KCNA5, BMPR2, KCNK3, CAV1
response to abiotic stimulus (GO:0009628) -2.80.023SMAD9, KCNK3, CAV1, KCNA5
cytosolic calcium ion homeostasis (GO:0051480) -4.410.005KCNK3, CAV1, KCNA5
response to decreased oxygen levels (GO:0036293) -4.090.0SMAD9, KCNA5, BMPR2, KCNK3, CAV1
chemical homeostasis (GO:0048878) -2.970.025SMAD9, KCNA5, BMPR2, KCNK3, CAV1
cell-cell signaling (GO:0007267) NEW3.350.024SMAD9, KCNA5, BMPR2, KCNK3, CAV1
negative regulation of cytosolic calcium ion concentration (GO:0051481) -7.330.001KCNK3, KCNA5
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.285SMAD9, KCNK3, BMPR2, KCNA5, CAV1
cell part (GO:0044464) 0.115SMAD9, KCNK3, BMPR2, KCNA5, CAV1
plasma membrane part (GO:0044459) 1.954KCNK3, BMPR2, KCNA5, CAV1
integral component of membrane (GO:0016021) 1.144KCNK3, CAV1, KCNA5, BMPR2
membrane (GO:0016020) 0.684KCNK3, CAV1, KCNA5, BMPR2
cytoplasmic part (GO:0044444) 0.824SMAD9, KCNK3, CAV1, KCNA5
integral component of plasma membrane (GO:0005887) 2.574KCNK3, BMPR2, KCNA5, CAV1
plasma membrane (GO:0005886) 1.394KCNK3, CAV1, KCNA5, BMPR2
membrane part (GO:0044425) 0.954KCNK3, CAV1, KCNA5, BMPR2
intrinsic component of plasma membrane (GO:0031226) 2.534KCNK3, CAV1, KCNA5, BMPR2
cytosol (GO:0005829) 1.684SMAD9, KCNK3, CAV1, KCNA5
intrinsic component of membrane (GO:0031224) 1.134KCNK3, BMPR2, KCNA5, CAV1
protein complex (GO:0043234) 1.513SMAD9, CAV1, KCNA5
plasma membrane region (GO:0098590) 2.973BMPR2, KCNA5, CAV1
membrane raft (GO:0045121) 4.183BMPR2, KCNA5, CAV1
macromolecular complex (GO:0032991) 1.353SMAD9, CAV1, KCNA5
intracellular membrane-bounded organelle (GO:0043231) 0.63SMAD9, CAV1, KCNA5
membrane region (GO:0098589) 3.953BMPR2, KCNA5, CAV1
cytoplasm (GO:0005737) 1.013SMAD9, BMPR2, CAV1
caveola (GO:0005901) 5.553BMPR2, KCNA5, CAV1
intracellular organelle (GO:0043229) 0.513SMAD9, CAV1, KCNA5
plasma membrane raft (GO:0044853) 5.423BMPR2, KCNA5, CAV1
membrane microdomain (GO:0098857) 4.173BMPR2, KCNA5, CAV1
membrane-bounded organelle (GO:0043227) 0.473SMAD9, CAV1, KCNA5
organelle (GO:0043226) 0.43SMAD9, CAV1, KCNA5
organelle part (GO:0044422) 0.793SMAD9, CAV1, KCNA5
Golgi apparatus (GO:0005794) 2.72CAV1, KCNA5
endoplasmic reticulum (GO:0005783) 2.562CAV1, KCNA5
apical plasma membrane (GO:0016324) 4.132BMPR2, CAV1
cell surface (GO:0009986) 3.442BMPR2, CAV1
intracellular (GO:0005622) 2.372SMAD9, CAV1
intracellular organelle part (GO:0044446) 0.812SMAD9, CAV1
membrane protein complex (GO:0098796) 2.842CAV1, KCNA5
basal plasma membrane (GO:0009925) 6.342BMPR2, CAV1
perinuclear region of cytoplasm (GO:0048471) 3.352CAV1, KCNA5
cell projection (GO:0042995) 2.472BMPR2, CAV1
cell junction (GO:0030054) 2.752CAV1, KCNA5

NET-GE enrichment

Term New enriched termICP valueGenes
cell body (GO:0044297) NEW3.740.009SMAD9, BMPR2, KCNA5, CAV1
plasma membrane region (GO:0098590) -2.970.027SMAD9, BMPR2, KCNA5, CAV1
neuronal cell body (GO:0043025) NEW3.90.005SMAD9, BMPR2, KCNA5, CAV1
dendrite (GO:0030425) NEW3.920.005SMAD9, BMPR2, KCNA5, CAV1