Disease table of SCLEROSTEOSIS OMIM ID: PS269500

Gene-disease associations table

GeneAssociated with SCLEROSTEOSIS inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
SOSTClinVar, OMIM, HUMSAVARHGNC link17q21.313PS269500, 239100, 122860
LRP4ClinVar, OMIM, HUMSAVARHGNC link11p11.23PS269500, 212780, PS601462

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
SOSTYES3MEF2C, MEF2D, MEF2A0
Interactions from BIOGRID - physical
Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
SOSTLRP4Yesbinding0

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
LRP4SOSTyes, they interactThey are in interaction. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment (no shared terms)
REACTOME pathways annotation: shared terms / NET-GE enrichment (no shared terms)
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.182SOST, LRP4
protein binding (GO:0005515) 0.462SOST, LRP4

NET-GE enrichment

Term New enriched termICP valueGenes
sulfur compound binding (GO:1901681) NEW4.320.027SOST, LRP4
glycosaminoglycan binding (GO:0005539) NEW4.420.023SOST, LRP4
heparin binding (GO:0008201) NEW4.680.014SOST, LRP4
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
regulation of RNA metabolic process (GO:0051252) 1.522SOST, LRP4
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432SOST, LRP4
positive regulation of metabolic process (GO:0009893) 1.742SOST, LRP4
regulation of metabolic process (GO:0019222) 1.022SOST, LRP4
regulation of cellular biosynthetic process (GO:0031326) 1.382SOST, LRP4
negative regulation of response to stimulus (GO:0048585) 2.522SOST, LRP4
regulation of response to stimulus (GO:0048583) 1.542SOST, LRP4
negative regulation of cellular component organization (GO:0051129) 3.352SOST, LRP4
regulation of cellular component organization (GO:0051128) 2.012SOST, LRP4
negative regulation of signaling (GO:0023057) 2.652SOST, LRP4
regulation of Wnt signaling pathway (GO:0030111) 3.982SOST, LRP4
signal transduction (GO:0007165) 1.282SOST, LRP4
cell surface receptor signaling pathway (GO:0007166) 2.092SOST, LRP4
regulation of signaling (GO:0023051) 1.722SOST, LRP4
regulation of cell communication (GO:0010646) 1.732SOST, LRP4
regulation of biological process (GO:0050789) 0.452SOST, LRP4
single-organism process (GO:0044699) 0.482SOST, LRP4
regulation of primary metabolic process (GO:0080090) 1.082SOST, LRP4
positive regulation of macromolecule metabolic process (GO:0010604) 1.812SOST, LRP4
negative regulation of signal transduction (GO:0009968) 2.752SOST, LRP4
regulation of signal transduction (GO:0009966) 1.842SOST, LRP4
negative regulation of multicellular organismal process (GO:0051241) 2.842SOST, LRP4
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.462SOST, LRP4
negative regulation of Wnt signaling pathway (GO:0030178) 4.442SOST, LRP4
regulation of developmental process (GO:0050793) 2.12SOST, LRP4
regulation of macromolecule biosynthetic process (GO:0010556) 1.432SOST, LRP4
biological regulation (GO:0065007) 0.392SOST, LRP4
positive regulation of biological process (GO:0048518) 1.22SOST, LRP4
negative regulation of biological process (GO:0048519) 1.332SOST, LRP4
positive regulation of cellular metabolic process (GO:0031325) 1.812SOST, LRP4
negative regulation of canonical Wnt signaling pathway (GO:0090090) 4.632SOST, LRP4
multicellular organismal process (GO:0032501) 1.452SOST, LRP4
regulation of macromolecule metabolic process (GO:0060255) 1.082SOST, LRP4
regulation of cellular metabolic process (GO:0031323) 1.072SOST, LRP4
cellular process (GO:0009987) 0.262SOST, LRP4
regulation of biosynthetic process (GO:0009889) 1.372SOST, LRP4
regulation of nucleic acid-templated transcription (GO:1903506) 1.552SOST, LRP4
regulation of cellular process (GO:0050794) 0.52SOST, LRP4
regulation of nitrogen compound metabolic process (GO:0051171) 1.362SOST, LRP4
regulation of multicellular organismal process (GO:0051239) 1.872SOST, LRP4
regulation of RNA biosynthetic process (GO:2001141) 1.552SOST, LRP4
regulation of ossification (GO:0030278) 4.532SOST, LRP4
negative regulation of ossification (GO:0030279) 5.482SOST, LRP4
negative regulation of developmental process (GO:0051093) 3.172SOST, LRP4
single-multicellular organism process (GO:0044707) 1.782SOST, LRP4
Wnt signaling pathway (GO:0016055) 3.882SOST, LRP4
regulation of gene expression (GO:0010468) 1.372SOST, LRP4
regulation of transcription, DNA-templated (GO:0006355) 1.562SOST, LRP4
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242SOST, LRP4
regulation of multicellular organismal development (GO:2000026) 2.312SOST, LRP4
negative regulation of cellular process (GO:0048523) 1.412SOST, LRP4
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.792SOST, LRP4
positive regulation of cellular process (GO:0048522) 1.32SOST, LRP4
regulation of canonical Wnt signaling pathway (GO:0060828) 4.262SOST, LRP4
negative regulation of cell communication (GO:0010648) 2.662SOST, LRP4

NET-GE enrichment

Term New enriched termICP valueGenes
negative regulation of canonical Wnt signaling pathway (GO:0090090) -4.630.004SOST, LRP4
embryonic digit morphogenesis (GO:0042733) NEW5.690.01SOST, LRP4
dorsal/ventral pattern formation (GO:0009953) NEW5.60.038SOST, LRP4
negative regulation of axonogenesis (GO:0050771) NEW5.520.015SOST, LRP4
hair follicle development (GO:0001942) NEW6.020.012SOST, LRP4
Wnt signaling pathway (GO:0016055) -3.880.031SOST, LRP4
hair cycle process (GO:0022405) NEW5.540.04SOST, LRP4
regulation of Wnt signaling pathway (GO:0030111) -3.980.025SOST, LRP4
negative regulation of Wnt signaling pathway (GO:0030178) -4.440.009SOST, LRP4
molting cycle process (GO:0022404) NEW5.540.04SOST, LRP4
odontogenesis of dentin-containing tooth (GO:0042475) NEW5.520.033SOST, LRP4
regulation of ossification (GO:0030278) -4.530.016SOST, LRP4
negative regulation of ossification (GO:0030279) -5.480.0SOST, LRP4
regulation of canonical Wnt signaling pathway (GO:0060828) -4.260.012SOST, LRP4
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
intracellular part (GO:0044424) 0.282SOST, LRP4
intracellular organelle (GO:0043229) 0.512SOST, LRP4
cell part (GO:0044464) 0.112SOST, LRP4
organelle (GO:0043226) 0.42SOST, LRP4

NET-GE enrichment

Term New enriched termICP valueGenes
synapse (GO:0045202) NEW3.580.047SOST, LRP4
proteinaceous extracellular matrix (GO:0005578) NEW4.010.036SOST, LRP4