Disease table of MYASTHENIC SYNDROME, CONGENITAL OMIM ID: PS601462

Gene-disease associations table

GeneAssociated with MYASTHENIC SYNDROME, CONGENITAL inLink to HGNCCytogenetic bandNumber of associated diseasesAssociated diseases
MUSKClinVar, OMIM, HUMSAVARHGNC link9q31.32PS601462, 208150
ALG2ClinVar, OMIM, HUMSAVARHGNC link9q22.332PS212065, PS601462
TACO1ClinVarHGNC link17q23.32PS601462, 220110
COLQClinVar, OMIM, HUMSAVARHGNC link3p25.11PS601462
AGRNClinVar, OMIM, HUMSAVARHGNC link1p36.331PS601462
CHATClinVar, OMIM, HUMSAVARHGNC link10q11.231PS601462
CHRNB1ClinVar, OMIM, HUMSAVARHGNC link17p13.11PS601462
DOK7ClinVar, OMIM, HUMSAVARHGNC link4p16.32PS601462, 208150
SCN4AClinVar, OMIM, HUMSAVARHGNC link17q23.36PS601462, 170400, 170500, 613345, 608390, 168300
DPAGT1ClinVar, OMIM, HUMSAVARHGNC link11q23.32PS212065, PS601462
SURF1ClinVarHGNC link9q34.23PS118220, PS601462, 256000
CHRNA1ClinVar, OMIM, HUMSAVARHGNC link2q31.13236750, 253290, PS601462
ALG14ClinVar, OMIM, HUMSAVARHGNC link1p21.31PS601462
SNAP25ClinVar, OMIM, HUMSAVARHGNC link20p12.21PS601462
LRP4ClinVar, OMIM, HUMSAVARHGNC link11p11.23PS269500, 212780, PS601462
SYT2ClinVar, OMIM, HUMSAVARHGNC link1q32.11PS601462
RAPSNClinVar, OMIM, HUMSAVARHGNC link11p11.22PS601462, 208150
COL13A1OMIMHGNC link10q22.11PS601462
CHRNDClinVar, OMIM, HUMSAVARHGNC link2q37.12PS601462, 253290
CHRNEClinVar, OMIM, HUMSAVARHGNC link17p13.21PS601462
COX10ClinVarHGNC link17p123256000, 220110, PS601462
GFPT1ClinVar, OMIM, HUMSAVARHGNC link2p13.31PS601462
COX15ClinVarHGNC link10q24.23256000, PS601462, 615119

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Relations among genes:

Tandem repeat annotations from DGD
Cytogenetic band analysis
By sub-band
Shared sub_bandNumber of genes associated with the diseaseGenes associated with the disease
11p11.22LRP4, RAPSN
17q23.32SCN4A, TACO1
By band
Shared bandNumber of genes associated with the diseaseGenes associated with the disease
11p112LRP4, RAPSN
17p132CHRNB1, CHRNE
17q232SCN4A, TACO1
By region
Shared regionNumber of genes associated with the diseaseGenes associated with the disease
17q22SCN4A, TACO1
2q32CHRNA1, CHRND
17p13CHRNB1, CHRNE, COX10
10q22COL13A1, COX15
11p12LRP4, RAPSN
9q32MUSK, SURF1
By arm
Shared armNumber of genes associated with the diseaseGenes associated with the disease
1p2AGRN, ALG14
2q2CHRNA1, CHRND
11p2LRP4, RAPSN
9q3MUSK, ALG2, SURF1
10q3CHAT, COL13A1, COX15
17q2SCN4A, TACO1
17p3CHRNB1, CHRNE, COX10
By chromosome
Shared chromosomeNumber of genes associated with the diseaseGenes associated with the disease
113LRP4, RAPSN, DPAGT1
103CHAT, COL13A1, COX15
175CHRNB1, SCN4A, TACO1, COX10, CHRNE
13AGRN, SYT2, ALG14
23CHRNA1, CHRND, GFPT1
93MUSK, ALG2, SURF1
Transcription Factors (TF) annotation from TRRUST
regulated geneassociated to this disease# TFsTFs # TFs associated with this diseaseTFs associated with this disease
CHATYES2ESR1, ESR20
SURF1YES2MYC, YY10
CHRNA1YES1AIRE0
SNAP25YES1SP10
CHRNEYES2GABPA, ETS20
Interactions from BIOGRID - physical
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
MUSKALG2No1HSP90AA1
MUSKRAPSNNo1HSP90AA1
ALG2RAPSNNo1HSP90AA1
TACO1SNAP25No1APP
AGRNSURF1No2NXF1, MOV10
AGRNLRP4No1ZFP41
AGRNRAPSNNo1DAG1
DOK7GFPT1No1CRK
SURF1COX15Yes3NDUFS8, NDUFA12, CYC1
CHRNA1CHRNDYes0
CHRNA1CHRNEYes0
SNAP25SYT2No1HTT
CHRNDCHRNENo1CHRNA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic
Interactions from STRING
Gene1Gene2Direct InteractionInteraction modeNumber of shared interactorsShared genes in interaction
MUSKCOLQYesbinding0
MUSKCHRNB1Yesbinding5SRC, CHRNG, PTK2B, RAPSN, PTK2
MUSKDOK7Yesbinding0
MUSKCHRNA1No-10PAK3, RAPSN, PAK4, PAK2, CHRNG, PTK2, SRC, PAK6, PAK1, PAK7
MUSKLRP4Yesbinding0
MUSKRAPSNYesbinding11PTK2B, PAK3, CHRNB1, PAK2, CHRNG, PTK2, PAK4, SRC, PAK6, PAK1, PAK7
MUSKCHRNDNo-1CHRNB1
MUSKCHRNENo-1CHRNB1
COLQCHRNB1No-1MUSK
COLQDOK7No-1MUSK
COLQLRP4No-1MUSK
COLQRAPSNNo-1MUSK
CHRNB1DOK7No-1MUSK
CHRNB1CHRNA1No-6RAPSN, PTK2, CHRNG, SRC, CHRND, CHRNE
CHRNB1LRP4No-1MUSK
CHRNB1RAPSNYesbinding5SRC, PTK2B, CHRNG, PTK2, MUSK
CHRNB1CHRNDYesbinding10CHRNA4, CHRNB2, CHRNA3, CHRNA2, CHRNB4, CHRNA5, CHRNA6, CHRNB3, CHRNA7, CHRNE
CHRNB1CHRNEYesbinding10CHRNA4, CHRNA3, CHRNB2, CHRNA2, CHRNB3, CHRNA5, CHRNA6, CHRNB4, CHRNA7, CHRND
DOK7LRP4No-1MUSK
DOK7RAPSNNo-1MUSK
DPAGT1ALG14Yesactivation, binding1ALG13
DPAGT1GFPT1No-1UBC
SURF1COX10No-1MT-CO1
CHRNA1LRP4No-0
CHRNA1RAPSNYesbinding29ACTA1, LAMA5, PXN, PAK2, CHRNG, PAK4, LAMB3, PAK6, CHRM1, CTTN, LAMB1, LAMA3, PTK2, LAMA2, PAK7, PAK1, ARHGEF6, LAMC3, UTRN, LAMB2, SRC, DAG1, PAK3, GIT2, ITGB1, ARHGEF7, LAMC2, ITGA1, LAMC1
CHRNA1COL13A1No-2ITGA1, ITGB1
CHRNA1CHRNDYesbinding1CHRNE
CHRNA1CHRNEYesbinding2JUN, CHRND
LRP4RAPSNNo-1MUSK
RAPSNCOL13A1No-2ITGA1, ITGB1
RAPSNCHRNDNo-2CHRNA1, CHRNB1
RAPSNCHRNENo-2CHRNA1, CHRNB1
CHRNDCHRNEYesbinding11CHRNA4, CHRNA3, CHRNB2, CHRNA1, CHRNA2, CHRNB4, CHRNA5, CHRNA6, CHRNB3, CHRNB1, CHRNA7
COX10COX15Yesbinding1COX11

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM
Interactions from CENSUS
Gene1Gene2Direct InteractionNumber of shared interactorsShared genes in interaction
SURF1COX15Yes4NDUFS8, MT-CO2, CYC1, NDUFA12

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from PDB
Interactions from manually curated literature
Gene1Gene2Direct interactionMore information
CHRNA1CHRNDyes, complexPentamer of two alpha chains, and one each of the beta, delta, and gamma (in immature muscle) or epsilon (in mature muscle) chains. [UniProt]
DOK7MUSKyes, complexThey form a heterotetramer composed of 2 DOK7 and 2 MUSK molecules. [UniProt]
KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG termKEGG term IDICNumber of genes with the same termGenes
Metabolic pathwayshsa011002.496COX15, GFPT1, ALG14, ALG2, DPAGT1, COX10
Neuroactive ligand-receptor interactionhsa040804.584CHRND, CHRNE, CHRNA1, CHRNB1
N-Glycan biosynthesishsa005107.073DPAGT1, ALG14, ALG2
Porphyrin and chlorophyll metabolismhsa008607.412COX15, COX10
Oxidative phosphorylationhsa001905.692COX15, COX10

NET-GE enrichment

Term New enriched termICP valueGenes
N-Glycan biosynthesis (hsa00510) -7.070.004DPAGT1, ALG14, ALG2
REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME termREACTOME term IDICNumber of genes with the same termGenes
MetabolismR-HSA-14307282.347COX15, TACO1, SNAP25, SURF1, COX10, AGRN, CHAT
DiseaseR-HSA-16436853.337ALG14, GFPT1, SNAP25, SYT2, ALG2, DPAGT1, AGRN
Neuronal SystemR-HSA-1123164.825CHRND, CHRNE, CHAT, SNAP25, CHRNA1
Diseases of glycosylationR-HSA-37818656.895DPAGT1, GFPT1, AGRN, ALG2, ALG14
Transmission across Chemical SynapsesR-HSA-1123155.285CHRND, CHRNE, CHRNA1, SNAP25, CHAT
Post-translational protein modificationR-HSA-5975924.544DPAGT1, GFPT1, ALG14, ALG2
Extracellular matrix organizationR-HSA-14742444.914LRP4, COL13A1, MUSK, AGRN
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent proteinR-HSA-4461936.924DPAGT1, GFPT1, ALG14, ALG2
Metabolism of proteinsR-HSA-3924993.414DPAGT1, GFPT1, ALG14, ALG2
Asparagine N-linked glycosylationR-HSA-4462036.14DPAGT1, GFPT1, ALG14, ALG2
Acetylcholine Binding And Downstream EventsR-HSA-1814319.183CHRND, CHRNE, CHRNA1
Activation of Nicotinic Acetylcholine ReceptorsR-HSA-6296029.183CHRND, CHRNE, CHRNA1
ECM proteoglycansR-HSA-30001786.753LRP4, AGRN, MUSK
Postsynaptic nicotinic acetylcholine receptorsR-HSA-6223279.183CHRND, CHRNE, CHRNA1
Presynaptic nicotinic acetylcholine receptorsR-HSA-6223239.43CHRND, CHRNE, CHRNA1
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellR-HSA-1123145.853CHRND, CHRNE, CHRNA1
Diseases associated with N-glycosylation of proteinsR-HSA-37818608.893DPAGT1, ALG14, ALG2
Integrin cell surface interactionsR-HSA-2160836.572COL13A1, AGRN
Infectious diseaseR-HSA-56632054.472SYT2, SNAP25
Transcriptional Regulation by TP53R-HSA-37009896.732SURF1, TACO1
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.R-HSA-1632006.122SURF1, TACO1
Acetylcholine Neurotransmitter Release CycleR-HSA-2646428.892CHAT, SNAP25
Gene ExpressionR-HSA-741602.722SURF1, TACO1
Generic Transcription PathwayR-HSA-2124363.862SURF1, TACO1
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.712SURF1, TACO1
Heme biosynthesisR-HSA-1894519.522COX15, COX10
Respiratory electron transportR-HSA-6111056.442SURF1, TACO1
Highly sodium permeable acetylcholine nicotinic receptorsR-HSA-62958710.182CHRND, CHRNE
Developmental BiologyR-HSA-12667383.482SCN4A, AGRN
Neurotoxicity of clostridium toxinsR-HSA-1687999.662SYT2, SNAP25
Metabolism of porphyrinsR-HSA-1894458.892COX15, COX10
Uptake and actions of bacterial toxinsR-HSA-53395628.282SYT2, SNAP25
TP53 Regulates Metabolic GenesR-HSA-56288976.732SURF1, TACO1
Axon guidanceR-HSA-4224753.932SCN4A, AGRN
Neurotransmitter Release CycleR-HSA-1123107.342CHAT, SNAP25

NET-GE enrichment

Term New enriched termICP valueGenes
Acetylcholine Binding And Downstream Events (R-HSA-181431) -9.180.0CHRND, CHRNE, CHRNA1
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (R-HSA-446193) -6.920.001DPAGT1, GFPT1, ALG14, ALG2
Activation of Nicotinic Acetylcholine Receptors (R-HSA-629602) -9.180.0CHRND, CHRNE, CHRNA1
Heme biosynthesis (R-HSA-189451) -9.520.025COX15, COX10
Highly sodium permeable acetylcholine nicotinic receptors (R-HSA-629587) -10.180.014CHRND, CHRNE
Neurotoxicity of clostridium toxins (R-HSA-168799) -9.660.02SYT2, SNAP25
Asparagine N-linked glycosylation (R-HSA-446203) -6.10.012DPAGT1, GFPT1, ALG14, ALG2
Postsynaptic nicotinic acetylcholine receptors (R-HSA-622327) -9.180.0CHRND, CHRNE, CHRNA1
Presynaptic nicotinic acetylcholine receptors (R-HSA-622323) -9.40.0CHRND, CHRNE, CHRNA1
Neuronal System (R-HSA-112316) -4.820.036CHRND, CHRNE, CHAT, SNAP25, CHRNA1
Diseases of glycosylation (R-HSA-3781865) -6.890.0DPAGT1, GFPT1, AGRN, ALG2, ALG14
Transmission across Chemical Synapses (R-HSA-112315) -5.280.008CHRNA1, SNAP25, MUSK, CHRND, CHRNE, CHAT
Diseases associated with N-glycosylation of proteins (R-HSA-3781860) -8.890.004DPAGT1, ALG14, ALG2
GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
binding (GO:0005488) 0.1817COL13A1, COLQ, CHRNA1, GFPT1, CHAT, RAPSN, DOK7, CHRNB1, SYT2, SNAP25, SURF1, LRP4, AGRN, CHRND, ALG2, CHRNE, MUSK
protein binding (GO:0005515) 0.4611COL13A1, COLQ, RAPSN, DOK7, LRP4, SYT2, SURF1, SNAP25, AGRN, ALG2, MUSK
ion binding (GO:0043167) 1.3611CHRNA1, GFPT1, CHAT, RAPSN, CHRNB1, SYT2, LRP4, AGRN, CHRND, CHRNE, MUSK
cation binding (GO:0043169) 1.410CHRNA1, CHAT, RAPSN, CHRNB1, SYT2, LRP4, AGRN, CHRND, CHRNE, MUSK
catalytic activity (GO:0003824) 1.059COX15, CHAT, GFPT1, ALG14, SURF1, ALG2, DPAGT1, COX10, MUSK
substrate-specific transmembrane transporter activity (GO:0022891) 2.98COX15, SCN4A, CHRNA1, SURF1, CHRNB1, CHRND, CHRNE, COX10
substrate-specific transporter activity (GO:0022892) 2.728COX15, SCN4A, CHRNA1, SURF1, CHRNB1, CHRND, CHRNE, COX10
transporter activity (GO:0005215) 2.578COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
cation transmembrane transporter activity (GO:0008324) 3.328COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
ion transmembrane transporter activity (GO:0015075) 3.048COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
transmembrane transporter activity (GO:0022857) 2.828COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
transferase activity (GO:0016740) 1.957CHAT, GFPT1, ALG14, ALG2, DPAGT1, COX10, MUSK
substrate-specific channel activity (GO:0022838) 3.675SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
cation channel activity (GO:0005261) 4.045SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
ion channel activity (GO:0005216) 3.715SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
ammonium ion binding (GO:0070405) 5.815CHRND, CHRNE, CHRNA1, CHRNB1, CHAT
molecular transducer activity (GO:0060089) 2.325CHRND, CHRNE, MUSK, CHRNB1, CHRNA1
transmembrane signaling receptor activity (GO:0004888) 2.575CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
channel activity (GO:0015267) 3.65SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
gated channel activity (GO:0022836) 3.965SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
signal transducer activity (GO:0004871) 2.285CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
passive transmembrane transporter activity (GO:0022803) 3.65SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
signaling receptor activity (GO:0038023) 2.495CHRND, CHRNE, MUSK, CHRNB1, CHRNA1
metal ion binding (GO:0046872) 1.415SYT2, LRP4, RAPSN, AGRN, MUSK
transmembrane receptor activity (GO:0099600) 2.535CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
receptor activity (GO:0004872) 2.325CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
inorganic cation transmembrane transporter activity (GO:0022890) 3.494SURF1, COX15, SCN4A, COX10
neurotransmitter receptor activity (GO:0030594) 5.54CHRND, CHRNE, CHRNA1, CHRNB1
extracellular ligand-gated ion channel activity (GO:0005230) 5.424CHRND, CHRNE, CHRNA1, CHRNB1
excitatory extracellular ligand-gated ion channel activity (GO:0005231) 5.734CHRND, CHRNE, CHRNA1, CHRNB1
ligand-gated ion channel activity (GO:0015276) 4.84CHRND, CHRNE, CHRNA1, CHRNB1
acetylcholine receptor activity (GO:0015464) 6.34CHRND, CHRNE, CHRNA1, CHRNB1
acetylcholine binding (GO:0042166) 6.564CHRND, CHRNE, CHRNA1, CHRNB1
monovalent inorganic cation transmembrane transporter activity (GO:0015077) 3.874SCN4A, COX15, SURF1, COX10
acetylcholine-activated cation-selective channel activity (GO:0004889) 6.654CHRND, CHRNE, CHRNA1, CHRNB1
neurotransmitter binding (GO:0042165) 6.344CHRND, CHRNE, CHRNA1, CHRNB1
ligand-gated channel activity (GO:0022834) 4.84CHRND, CHRNE, CHRNA1, CHRNB1
cytochrome-c oxidase activity (GO:0004129) 6.343SURF1, COX15, COX10
carbohydrate derivative binding (GO:0097367) 2.033COL13A1, MUSK, AGRN
oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor (GO:0016676) 6.343SURF1, COX15, COX10
calcium ion binding (GO:0005509) 3.173SYT2, LRP4, AGRN
transferase activity, transferring glycosyl groups (GO:0016757) 4.083DPAGT1, ALG14, ALG2
oxidoreductase activity, acting on a heme group of donors (GO:0016675) 6.33SURF1, COX15, COX10
receptor binding (GO:0005102) 2.433DOK7, RAPSN, LRP4
electron carrier activity (GO:0009055) 4.973SURF1, COX15, COX10
hydrogen ion transmembrane transporter activity (GO:0015078) 5.013SURF1, COX15, COX10
heme-copper terminal oxidase activity (GO:0015002) 6.343SURF1, COX15, COX10
oxidoreductase activity (GO:0016491) 3.123SURF1, COX15, COX10
sulfur compound binding (GO:1901681) 4.322COL13A1, AGRN
anion binding (GO:0043168) 4.172GFPT1, AGRN
calcium-dependent protein binding (GO:0048306) 5.682SNAP25, ALG2
transferase activity, transferring phosphorus-containing groups (GO:0016772) 2.772DPAGT1, MUSK
SNARE binding (GO:0000149) 4.872SYT2, SNAP25
carboxylic acid binding (GO:0031406) 4.642GFPT1, AGRN
lipid binding (GO:0008289) 3.262SYT2, DOK7
enzyme binding (GO:0019899) 2.272DOK7, LRP4
protein kinase binding (GO:0019901) 3.442DOK7, LRP4
kinase binding (GO:0019900) 3.322DOK7, LRP4
small molecule binding (GO:0036094) 1.892SYT2, MUSK
syntaxin binding (GO:0019905) 5.192SYT2, SNAP25
transferase activity, transferring hexosyl groups (GO:0016758) 4.432ALG14, ALG2
protein dimerization activity (GO:0046983) 2.722LRP4, ALG2
glycosaminoglycan binding (GO:0005539) 4.422COL13A1, AGRN

NET-GE enrichment

Term New enriched termICP valueGenes
cation channel activity (GO:0005261) -4.040.001CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
acetylcholine receptor regulator activity (GO:0030548) NEW8.640.002AGRN, MUSK
ligand-gated ion channel activity (GO:0015276) -4.80.004CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
acetylcholine-activated cation-selective channel activity (GO:0004889) -6.650.0CHRND, CHRNE, CHRNA1, CHRNB1
passive transmembrane transporter activity (GO:0022803) -3.60.021CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
extracellular ligand-gated ion channel activity (GO:0005230) -5.420.0CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
cation transmembrane transporter activity (GO:0008324) -3.320.001COX15, CHRNA1, SCN4A, CHRNB1, SURF1, SNAP25, CHRND, CHRNE, MUSK
transporter activity (GO:0005215) -2.570.01COX15, CHRNA1, SCN4A, SURF1, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, AGRN, MUSK
ion channel activity (GO:0005216) -3.710.015CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
excitatory extracellular ligand-gated ion channel activity (GO:0005231) -5.730.0CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
acetylcholine binding (GO:0042166) -6.560.029CHRND, CHRNB1
neurotransmitter binding (GO:0042165) -6.340.022CHRND, CHRNB1
channel activity (GO:0015267) -3.60.021CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
substrate-specific transmembrane transporter activity (GO:0022891) -2.90.047COX15, CHRNA1, SCN4A, CHRNB1, SURF1, SNAP25, CHRND, CHRNE, MUSK
substrate-specific transporter activity (GO:0022892) -2.720.02COX15, CHRNA1, SCN4A, CHRNB1, SURF1, SNAP25, CHRND, CHRNE, AGRN, MUSK
sialic acid binding (GO:0033691) NEW7.660.033MUSK, AGRN
ion transmembrane transporter activity (GO:0015075) -3.040.027COX15, CHRNA1, SCN4A, CHRNB1, SURF1, SNAP25, CHRND, CHRNE, MUSK
transmembrane transporter activity (GO:0022857) -2.820.014COX15, CHRNA1, SCN4A, SURF1, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, MUSK
farnesyltranstransferase activity (GO:0004311) NEW8.350.004COX15, COX10
gated channel activity (GO:0022836) -3.960.003CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
ligand-gated channel activity (GO:0022834) -4.80.004CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
substrate-specific channel activity (GO:0022838) -3.670.017CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cellular process (GO:0009987) 0.2620ALG14, COL13A1, COLQ, CHRNA1, RAPSN, CHAT, GFPT1, SURF1, LRP4, CHRNB1, SYT2, COX15, SNAP25, AGRN, DPAGT1, COX10, CHRNE, CHRND, ALG2, MUSK
single-organism cellular process (GO:0044763) 0.6520ALG14, COL13A1, COLQ, CHRNA1, CHRNE, CHAT, RAPSN, GFPT1, SURF1, LRP4, CHRNB1, SYT2, COX15, SNAP25, AGRN, DPAGT1, COX10, CHRND, ALG2, MUSK
single-organism process (GO:0044699) 0.4820ALG14, COX10, COL13A1, COLQ, CHRNA1, RAPSN, CHAT, GFPT1, SYT2, SNAP25, CHRNB1, SURF1, COX15, LRP4, AGRN, DPAGT1, ALG2, CHRNE, CHRND, MUSK
biological regulation (GO:0065007) 0.3916COLQ, CHRNA1, GFPT1, CHAT, RAPSN, TACO1, DOK7, CHRNB1, SYT2, SNAP25, LRP4, AGRN, CHRND, CHRNE, SCN4A, MUSK
localization (GO:0051179) 1.416COX15, COLQ, CHRNA1, CHRNE, CHAT, RAPSN, SYT2, CHRNB1, SURF1, SNAP25, LRP4, AGRN, CHRND, COX10, SCN4A, MUSK
regulation of biological process (GO:0050789) 0.4515COLQ, CHRNA1, GFPT1, SCN4A, RAPSN, TACO1, DOK7, CHRNB1, SYT2, SNAP25, LRP4, AGRN, CHRND, CHRNE, MUSK
cellular component organization or biogenesis (GO:0071840) 1.2215COL13A1, COLQ, CHRNA1, RAPSN, GFPT1, SURF1, CHRNB1, SYT2, SNAP25, COX15, LRP4, AGRN, DPAGT1, COX10, MUSK
cellular component organization (GO:0016043) 1.2415COL13A1, COLQ, CHRNA1, RAPSN, GFPT1, SURF1, CHRNB1, SYT2, SNAP25, COX15, LRP4, AGRN, DPAGT1, COX10, MUSK
regulation of cellular process (GO:0050794) 0.514COLQ, CHRNA1, GFPT1, RAPSN, TACO1, DOK7, CHRNB1, SYT2, SNAP25, LRP4, AGRN, CHRND, CHRNE, MUSK
multicellular organismal process (GO:0032501) 1.4513COL13A1, CHRNA1, CHAT, GFPT1, CHRNB1, SNAP25, LRP4, COX15, CHRND, CHRNE, SCN4A, AGRN, MUSK
establishment of localization (GO:0051234) 1.4813COX15, COLQ, CHRNA1, CHAT, SURF1, CHRNB1, SYT2, SNAP25, LRP4, CHRND, CHRNE, SCN4A, COX10
organic substance metabolic process (GO:0071704) 0.6312COL13A1, COLQ, CHAT, GFPT1, ALG14, SURF1, ALG2, COX15, DPAGT1, COX10, AGRN, MUSK
transport (GO:0006810) 1.5112COX15, CHRNA1, CHAT, SURF1, CHRNB1, SYT2, SNAP25, LRP4, CHRND, CHRNE, SCN4A, COX10
metabolic process (GO:0008152) 0.5812COL13A1, COLQ, CHAT, GFPT1, ALG14, SURF1, COX10, COX15, DPAGT1, ALG2, AGRN, MUSK
single-organism localization (GO:1902578) 2.0911COX15, COLQ, CHAT, RAPSN, SURF1, LRP4, SYT2, SNAP25, COX10, AGRN, MUSK
single-organism metabolic process (GO:0044710) 1.6311COL13A1, COLQ, CHAT, GFPT1, ALG14, SURF1, ALG2, COX15, DPAGT1, COX10, AGRN
single-multicellular organism process (GO:0044707) 1.7811COL13A1, CHRNA1, CHAT, GFPT1, CHRNB1, SNAP25, LRP4, COX15, CHRND, AGRN, MUSK
cellular metabolic process (GO:0044237) 0.6911COX15, COLQ, CHAT, GFPT1, ALG14, SURF1, ALG2, DPAGT1, COX10, AGRN, MUSK
organic substance biosynthetic process (GO:1901576) 1.349COX15, CHAT, GFPT1, ALG14, SURF1, AGRN, DPAGT1, ALG2, COX10
ion transport (GO:0006811) 2.669COX15, CHRNA1, SCN4A, CHRNB1, SURF1, SNAP25, CHRND, CHRNE, COX10
regulation of biological quality (GO:0065008) 1.689COLQ, CHRNA1, SCN4A, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, CHAT
biosynthetic process (GO:0009058) 1.329COX15, CHAT, GFPT1, ALG14, SURF1, AGRN, DPAGT1, ALG2, COX10
developmental process (GO:0032502) 1.368COL13A1, CHRNA1, CHAT, CHRNB1, LRP4, CHRND, AGRN, MUSK
membrane organization (GO:0061024) 3.048COLQ, RAPSN, CHRNB1, SYT2, SNAP25, LRP4, AGRN, MUSK
cation transport (GO:0006812) 3.118COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
single-organism developmental process (GO:0044767) 1.498COL13A1, CHRNA1, CHAT, CHRNB1, LRP4, CHRND, AGRN, MUSK
ion transmembrane transport (GO:0034220) 3.088COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
nitrogen compound metabolic process (GO:0006807) 1.138COX15, COLQ, CHAT, GFPT1, SURF1, AGRN, DPAGT1, COX10
single-organism membrane organization (GO:0044802) 3.198COLQ, RAPSN, CHRNB1, SYT2, SNAP25, LRP4, AGRN, MUSK
signal transduction (GO:0007165) 1.288CHRNA1, GFPT1, CHRNB1, LRP4, CHRND, CHRNE, AGRN, MUSK
cation transmembrane transport (GO:0098655) 3.438COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
transmembrane transport (GO:0055085) 2.728COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
system process (GO:0003008) 2.38CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, CHAT, MUSK
primary metabolic process (GO:0044238) 0.697GFPT1, ALG14, SURF1, ALG2, DPAGT1, AGRN, MUSK
single-organism biosynthetic process (GO:0044711) 2.87COX15, CHAT, ALG14, SURF1, ALG2, DPAGT1, COX10
cellular component assembly (GO:0022607) 2.147COX15, GFPT1, LRP4, SURF1, SNAP25, DPAGT1, COX10
protein complex subunit organization (GO:0071822) 2.67COX15, GFPT1, LRP4, SURF1, SNAP25, DPAGT1, COX10
single organism signaling (GO:0044700) 3.257CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, AGRN
macromolecular complex subunit organization (GO:0043933) 2.147COX15, GFPT1, LRP4, SURF1, SNAP25, DPAGT1, COX10
single-organism cellular localization (GO:1902580) 3.167COLQ, RAPSN, LRP4, SYT2, SNAP25, AGRN, MUSK
protein complex assembly (GO:0006461) 2.787COX15, GFPT1, LRP4, SURF1, SNAP25, DPAGT1, COX10
regulation of cellular component organization (GO:0051128) 2.017COLQ, RAPSN, LRP4, SYT2, SNAP25, AGRN, MUSK
macromolecular complex assembly (GO:0065003) 2.557COX15, GFPT1, LRP4, SURF1, SNAP25, DPAGT1, COX10
positive regulation of biological process (GO:0048518) 1.27RAPSN, DOK7, LRP4, SYT2, SNAP25, AGRN, MUSK
anterograde trans-synaptic signaling (GO:0098916) 3.987CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, AGRN
signaling (GO:0023052) 3.257CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, AGRN
chemical synaptic transmission (GO:0007268) 3.987CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, AGRN
cell-cell signaling (GO:0007267) 3.357CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, AGRN
cell communication (GO:0007154) 3.047CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, AGRN
positive regulation of cellular process (GO:0048522) 1.37RAPSN, DOK7, LRP4, SYT2, SNAP25, AGRN, MUSK
trans-synaptic signaling (GO:0099537) 3.987CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, AGRN
synaptic signaling (GO:0099536) 3.987CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, AGRN
cellular localization (GO:0051641) 2.327COLQ, RAPSN, LRP4, SYT2, SNAP25, AGRN, MUSK
cell surface receptor signaling pathway (GO:0007166) 2.096CHRNA1, CHRNB1, LRP4, CHRND, CHRNE, MUSK
regulation of metabolic process (GO:0019222) 1.026TACO1, GFPT1, LRP4, DOK7, MUSK, AGRN
cellular biosynthetic process (GO:0044249) 1.376COX15, GFPT1, SURF1, COX10, DPAGT1, CHAT
regulation of developmental process (GO:0050793) 2.16COLQ, LRP4, SYT2, SNAP25, AGRN, MUSK
neurological system process (GO:0050877) 2.646CHRNA1, CHRNB1, SNAP25, CHRND, CHAT, MUSK
response to stimulus (GO:0050896) 1.226GFPT1, CHRNA1, CHAT, CHRND, CHRNE, ALG2
regulation of cellular metabolic process (GO:0031323) 1.076TACO1, GFPT1, LRP4, DOK7, MUSK, AGRN
carbohydrate derivative biosynthetic process (GO:1901137) 3.736GFPT1, ALG14, SURF1, ALG2, DPAGT1, AGRN
single-organism transport (GO:0044765) 2.186COX15, SURF1, SNAP25, SYT2, CHAT, COX10
regulation of nervous system development (GO:0051960) 3.16COLQ, LRP4, SYT2, SNAP25, AGRN, MUSK
regulation of multicellular organismal development (GO:2000026) 2.316COLQ, LRP4, SYT2, SNAP25, AGRN, MUSK
regulation of multicellular organismal process (GO:0051239) 1.876COLQ, LRP4, SYT2, SNAP25, AGRN, MUSK
cellular developmental process (GO:0048869) 1.826COL13A1, CHRNB1, SYT2, LRP4, AGRN, MUSK
regulation of macromolecule metabolic process (GO:0060255) 1.086TACO1, GFPT1, LRP4, DOK7, MUSK, AGRN
response to chemical (GO:0042221) 1.986GFPT1, CHRNA1, CHAT, CHRND, CHRNE, ALG2
carbohydrate derivative metabolic process (GO:1901135) 3.076GFPT1, ALG14, SURF1, ALG2, DPAGT1, AGRN
regulation of primary metabolic process (GO:0080090) 1.086TACO1, GFPT1, LRP4, DOK7, MUSK, AGRN
regulation of membrane potential (GO:0042391) 3.895SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
protein localization (GO:0008104) 2.365COLQ, LRP4, RAPSN, MUSK, AGRN
regulation of cellular biosynthetic process (GO:0031326) 1.385TACO1, LRP4, GFPT1, AGRN, MUSK
cell differentiation (GO:0030154) 2.145SYT2, LRP4, COL13A1, AGRN, MUSK
regulation of synapse organization (GO:0050807) 5.035COLQ, LRP4, RAPSN, MUSK, AGRN
muscle system process (GO:0003012) 4.185SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
synaptic transmission, cholinergic (GO:0007271) 6.25CHRNE, CHRND, RAPSN, CHRNA1, CHRNB1
cell surface receptor signaling pathway involved in cell-cell signaling (GO:1905114) 3.795CHRND, LRP4, CHRNE, CHRNA1, CHRNB1
organic cyclic compound metabolic process (GO:1901360) 1.265GFPT1, SURF1, COX15, DPAGT1, COX10
cellular macromolecule localization (GO:0070727) 3.15COLQ, LRP4, RAPSN, AGRN, MUSK
regulation of cellular macromolecule biosynthetic process (GO:2000112) 1.465TACO1, LRP4, GFPT1, AGRN, MUSK
macromolecule localization (GO:0033036) 2.345COLQ, LRP4, RAPSN, AGRN, MUSK
regulation of gene expression (GO:0010468) 1.375GFPT1, LRP4, TACO1, MUSK, AGRN
muscle contraction (GO:0006936) 4.375SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
cellular aromatic compound metabolic process (GO:0006725) 1.35COX15, SURF1, GFPT1, DPAGT1, COX10
cellular protein localization (GO:0034613) 3.115COLQ, LRP4, RAPSN, AGRN, MUSK
regulation of biosynthetic process (GO:0009889) 1.375TACO1, LRP4, GFPT1, MUSK, AGRN
protein localization to membrane (GO:0072657) 3.955COLQ, LRP4, RAPSN, MUSK, AGRN
localization within membrane (GO:0051668) 5.625COLQ, LRP4, RAPSN, AGRN, MUSK
response to organic substance (GO:0010033) 2.25CHRNE, CHRND, GFPT1, CHAT, CHRNA1
heterocycle metabolic process (GO:0046483) 1.315COX15, SURF1, GFPT1, DPAGT1, COX10
organonitrogen compound metabolic process (GO:1901564) 2.325GFPT1, SURF1, COX15, AGRN, COX10
anatomical structure development (GO:0048856) 1.585AGRN, LRP4, COL13A1, MUSK, CHRNB1
cellular nitrogen compound metabolic process (GO:0034641) 1.225COX15, SURF1, GFPT1, DPAGT1, COX10
macromolecule metabolic process (GO:0043170) 0.835DPAGT1, ALG2, COL13A1, AGRN, MUSK
regulation of macromolecule biosynthetic process (GO:0010556) 1.435TACO1, LRP4, GFPT1, AGRN, MUSK
receptor clustering (GO:0043113) 6.025COLQ, LRP4, RAPSN, AGRN, MUSK
regulation of developmental growth (GO:0048638) 4.044COLQ, SYT2, AGRN, MUSK
synapse organization (GO:0050808) 4.874LRP4, MUSK, AGRN, CHRNA1
positive regulation of metabolic process (GO:0009893) 1.744DOK7, LRP4, MUSK, AGRN
developmental growth (GO:0048589) 4.054CHRND, LRP4, CHAT, CHRNA1
positive regulation of cellular metabolic process (GO:0031325) 1.814DOK7, LRP4, AGRN, MUSK
behavior (GO:0007610) 3.474CHRNB1, CHAT, SNAP25, MUSK
striated muscle contraction (GO:0006941) 5.374CHRND, CHRNE, CHRNA1, CHRNB1
regulation of neurotransmitter levels (GO:0001505) 4.774COLQ, SYT2, CHAT, SNAP25
cellular macromolecular complex assembly (GO:0034622) 3.184SURF1, COX15, SNAP25, COX10
generation of precursor metabolites and energy (GO:0006091) 4.074GFPT1, SURF1, COX15, COX10
organic cyclic compound biosynthetic process (GO:1901362) 1.664COX15, SURF1, GFPT1, COX10
regulation of cell projection organization (GO:0031344) 3.384SYT2, LRP4, SNAP25, AGRN
response to endogenous stimulus (GO:0009719) 2.794CHRNE, CHRND, GFPT1, CHRNA1
positive regulation of macromolecule metabolic process (GO:0010604) 1.814DOK7, LRP4, MUSK, AGRN
regulation of neuromuscular junction development (GO:1904396) 7.784COLQ, LRP4, MUSK, AGRN
neuromuscular synaptic transmission (GO:0007274) 6.434CHRND, CHRNE, CHRNA1, CHRNB1
regulation of growth (GO:0040008) 3.264COLQ, SYT2, AGRN, MUSK
regulation of protein metabolic process (GO:0051246) 1.934DOK7, TACO1, LRP4, MUSK
multicellular organism development (GO:0007275) 2.544LRP4, COL13A1, AGRN, MUSK
inorganic cation transmembrane transport (GO:0098662) 3.554SURF1, COX15, SCN4A, COX10
oxidation-reduction process (GO:0055114) 2.914COX15, SURF1, GFPT1, COX10
inorganic ion transmembrane transport (GO:0098660) 3.384SCN4A, COX15, SURF1, COX10
monovalent inorganic cation transport (GO:0015672) 3.744SCN4A, COX15, SURF1, COX10
heterocycle biosynthetic process (GO:0018130) 1.74COX15, SURF1, GFPT1, COX10
lipid metabolic process (GO:0006629) 2.684DPAGT1, AGRN, ALG2, ALG14
chemical synaptic transmission, postsynaptic (GO:0099565) 6.264CHRND, CHRNE, CHRNA1, CHRNB1
cellular lipid metabolic process (GO:0044255) 2.924DPAGT1, AGRN, ALG2, ALG14
regulation of localization (GO:0032879) 1.944SCN4A, LRP4, SYT2, SNAP25
cellular protein complex assembly (GO:0043623) 3.94SURF1, COX15, SNAP25, COX10
skeletal muscle contraction (GO:0003009) 6.334CHRND, CHRNE, CHRNA1, CHRNB1
growth (GO:0040007) 3.84CHRND, LRP4, CHRNA1, CHAT
regulation of cellular protein metabolic process (GO:0032268) 1.994DOK7, TACO1, LRP4, MUSK
cellular nitrogen compound biosynthetic process (GO:0044271) 1.594COX15, SURF1, GFPT1, COX10
energy derivation by oxidation of organic compounds (GO:0015980) 4.934GFPT1, SURF1, COX15, COX10
organonitrogen compound biosynthetic process (GO:1901566) 2.854SURF1, COX15, AGRN, COX10
single-organism behavior (GO:0044708) 3.794CHAT, SNAP25, CHRNB1, MUSK
response to organonitrogen compound (GO:0010243) 3.24CHRNE, CHRND, GFPT1, CHRNA1
skeletal muscle acetylcholine-gated channel clustering (GO:0071340) 7.534LRP4, RAPSN, COLQ, MUSK
aromatic compound biosynthetic process (GO:0019438) 1.74COX15, SURF1, GFPT1, COX10
response to nitrogen compound (GO:1901698) 3.124CHRNE, CHRND, GFPT1, CHRNA1
signal release from synapse (GO:0099643) 5.163SYT2, CHAT, SNAP25
regulation of phosphate metabolic process (GO:0019220) 2.353DOK7, LRP4, MUSK
regulation of neuron projection development (GO:0010975) 3.693SYT2, LRP4, SNAP25
hydrogen ion transmembrane transport (GO:1902600) 4.973SURF1, COX15, COX10
regulation of transport (GO:0051049) 2.243SCN4A, SYT2, SNAP25
establishment of localization in cell (GO:0051649) 2.473SYT2, CHAT, SNAP25
nucleobase-containing compound metabolic process (GO:0006139) 1.353SURF1, GFPT1, DPAGT1
cytochrome complex assembly (GO:0017004) 6.43SURF1, COX15, COX10
learning or memory (GO:0007611) 4.333CHAT, SNAP25, MUSK
secretion by cell (GO:0032940) 3.593SYT2, CHAT, SNAP25
small molecule metabolic process (GO:0044281) 2.383SURF1, GFPT1, DPAGT1
regulation of signaling (GO:0023051) 1.723RAPSN, LRP4, SNAP25
regulation of cell communication (GO:0010646) 1.733RAPSN, LRP4, SNAP25
regulation of cell differentiation (GO:0045595) 2.423SYT2, LRP4, SNAP25
response to organic cyclic compound (GO:0014070) 3.073CHRND, CHRNE, CHRNA1
cellular protein metabolic process (GO:0044267) 1.633DPAGT1, MUSK, ALG2
proton transport (GO:0015992) 4.733SURF1, COX15, COX10
cellular macromolecule metabolic process (GO:0044260) 0.933DPAGT1, ALG2, MUSK
dolichol-linked oligosaccharide biosynthetic process (GO:0006488) 7.023DPAGT1, ALG14, ALG2
positive regulation of phosphorus metabolic process (GO:0010562) 2.783DOK7, LRP4, MUSK
positive regulation of protein metabolic process (GO:0051247) 2.433DOK7, LRP4, MUSK
regulation of cell development (GO:0060284) 3.013SYT2, LRP4, SNAP25
regulation of neuron differentiation (GO:0045664) 3.393SYT2, LRP4, SNAP25
positive regulation of cellular protein metabolic process (GO:0032270) 2.493DOK7, LRP4, MUSK
regulation of protein modification process (GO:0031399) 2.323DOK7, LRP4, MUSK
positive regulation of cellular component organization (GO:0051130) 2.683SYT2, LRP4, AGRN
organelle organization (GO:0006996) 2.023SYT2, SNAP25, COX10
hydrogen transport (GO:0006818) 4.723SURF1, COX15, COX10
regulation of synaptic growth at neuromuscular junction (GO:0008582) 8.123COLQ, AGRN, MUSK
positive regulation of phosphate metabolic process (GO:0045937) 2.783DOK7, LRP4, MUSK
regulation of neurogenesis (GO:0050767) 3.213SYT2, LRP4, SNAP25
secretion (GO:0046903) 3.383SYT2, CHAT, SNAP25
cellular protein modification process (GO:0006464) 1.793DPAGT1, ALG2, MUSK
neuromuscular junction development (GO:0007528) 6.263LRP4, CHRNA1, MUSK
macromolecule modification (GO:0043412) 1.733DPAGT1, ALG2, MUSK
protein modification process (GO:0036211) 1.793DPAGT1, MUSK, ALG2
cellular respiration (GO:0045333) 5.93SURF1, COX15, COX10
protein oligomerization (GO:0051259) 3.713DPAGT1, GFPT1, LRP4
neurotransmitter secretion (GO:0007269) 5.73SYT2, CHAT, SNAP25
neurotransmitter transport (GO:0006836) 5.073SYT2, CHAT, SNAP25
signal release (GO:0023061) 4.653SYT2, CHAT, SNAP25
response to alkaloid (GO:0043279) 4.833CHRND, CHRNE, CHRNA1
catabolic process (GO:0009056) 2.383COL13A1, COLQ, AGRN
regulation of phosphorylation (GO:0042325) 2.53DOK7, LRP4, MUSK
regulation of phosphorus metabolic process (GO:0051174) 2.353DOK7, LRP4, MUSK
positive regulation of phosphorylation (GO:0042327) 2.93DOK7, LRP4, MUSK
carbohydrate metabolic process (GO:0005975) 3.263DPAGT1, GFPT1, ALG2
vesicle-mediated transport (GO:0016192) 2.723SYT2, LRP4, SNAP25
oligosaccharide-lipid intermediate biosynthetic process (GO:0006490) 7.023DPAGT1, ALG14, ALG2
protein metabolic process (GO:0019538) 1.453DPAGT1, MUSK, ALG2
positive regulation of protein modification process (GO:0031401) 2.73DOK7, LRP4, MUSK
cognition (GO:0050890) 4.23CHAT, SNAP25, MUSK
response to nicotine (GO:0035094) 5.783CHRND, CHRNE, CHRNA1
respiratory chain complex IV assembly (GO:0008535) 6.733SURF1, COX15, COX10
regulation of synapse assembly (GO:0051963) 5.363COLQ, AGRN, MUSK
regulation of cellular component biogenesis (GO:0044087) 3.083COLQ, MUSK, AGRN
phosphate-containing compound metabolic process (GO:0006796) 2.163SURF1, GFPT1, MUSK
phosphorus metabolic process (GO:0006793) 2.153SURF1, GFPT1, MUSK
presynaptic process involved in chemical synaptic transmission (GO:0099531) 4.983SYT2, CHAT, SNAP25
regulation of protein phosphorylation (GO:0001932) 2.573DOK7, LRP4, MUSK
positive regulation of protein phosphorylation (GO:0001934) 2.953DOK7, LRP4, MUSK
regulation of nitrogen compound metabolic process (GO:0051171) 1.363TACO1, LRP4, AGRN
neurotransmitter metabolic process (GO:0042133) 6.472COLQ, CHAT
regulation of secretion (GO:0051046) 3.22SYT2, SNAP25
vesicle fusion (GO:0006906) 5.22SYT2, SNAP25
neuronal action potential (GO:0019228) 6.42SCN4A, CHRNA1
memory (GO:0007613) 5.132CHAT, MUSK
porphyrin-containing compound metabolic process (GO:0006778) 6.092COX15, COX10
porphyrin-containing compound biosynthetic process (GO:0006779) 6.472COX15, COX10
membrane fusion (GO:0061025) 4.682SYT2, SNAP25
enzyme linked receptor protein signaling pathway (GO:0007167) 3.242LRP4, MUSK
action potential (GO:0001508) 5.422SCN4A, CHRNA1
establishment of organelle localization (GO:0051656) 4.152SYT2, SNAP25
establishment of vesicle localization (GO:0051650) 4.912SYT2, SNAP25
positive regulation of cell projection organization (GO:0031346) 3.992SYT2, AGRN
single-organism catabolic process (GO:0044712) 3.212COL13A1, COLQ
pigment metabolic process (GO:0042440) 5.592COX15, COX10
heme biosynthetic process (GO:0006783) 6.682COX15, COX10
heme a biosynthetic process (GO:0006784) 9.042COX15, COX10
rhythmic process (GO:0048511) 4.022GFPT1, CHAT
electron transport chain (GO:0022900) 5.092COX15, COX10
positive regulation of molecular function (GO:0044093) 2.232DOK7, AGRN
skeletal muscle tissue growth (GO:0048630) 8.122CHRND, CHRNA1
negative regulation of biological process (GO:0048519) 1.332GFPT1, LRP4
synaptic vesicle localization (GO:0097479) 5.312SYT2, SNAP25
regulation of RNA biosynthetic process (GO:2001141) 1.552LRP4, AGRN
establishment of synaptic vesicle localization (GO:0097480) 5.332SYT2, SNAP25
organelle membrane fusion (GO:0090174) 5.172SYT2, SNAP25
amino sugar metabolic process (GO:0006040) 6.152DPAGT1, GFPT1
regulation of peptidyl-tyrosine phosphorylation (GO:0050730) 4.352DOK7, LRP4
vesicle organization (GO:0016050) 4.132SYT2, SNAP25
UDP-N-acetylglucosamine metabolic process (GO:0006047) 7.092DPAGT1, GFPT1
positive regulation of peptidyl-tyrosine phosphorylation (GO:0050731) 4.622DOK7, LRP4
extracellular matrix organization (GO:0030198) 4.012COL13A1, AGRN
organophosphate metabolic process (GO:0019637) 3.042SURF1, GFPT1
regulation of cell morphogenesis (GO:0022604) 3.42SYT2, LRP4
regulation of anatomical structure morphogenesis (GO:0022603) 2.792SYT2, LRP4
aerobic respiration (GO:0009060) 6.42SURF1, COX10
synaptic vesicle transport (GO:0048489) 5.332SYT2, SNAP25
organic substance catabolic process (GO:1901575) 2.452COLQ, AGRN
cofactor metabolic process (GO:0051186) 3.912COX15, COX10
ammonium ion metabolic process (GO:0097164) 5.262COLQ, CHAT
exocytosis (GO:0006887) 4.112SYT2, SNAP25
cofactor biosynthetic process (GO:0051188) 4.622COX15, COX10
regulated exocytosis (GO:0045055) 4.442SYT2, SNAP25
nucleotide-sugar metabolic process (GO:0009225) 6.232DPAGT1, GFPT1
tetrapyrrole biosynthetic process (GO:0033014) 6.362COX15, COX10
tetrapyrrole metabolic process (GO:0033013) 5.652COX15, COX10
regulation of molecular function (GO:0065009) 1.782DOK7, AGRN
acetate ester metabolic process (GO:1900619) 8.122COLQ, CHAT
regulation of catalytic activity (GO:0050790) 1.972DOK7, AGRN
response to stress (GO:0006950) 1.82GFPT1, CHAT
macromolecule glycosylation (GO:0043413) 4.22DPAGT1, ALG2
single-organism membrane fusion (GO:0044801) 4.892SYT2, SNAP25
nucleobase-containing compound biosynthetic process (GO:0034654) 1.722SURF1, GFPT1
pigment biosynthetic process (GO:0046148) 5.862COX15, COX10
endocytosis (GO:0006897) 3.692SYT2, LRP4
synaptic vesicle exocytosis (GO:0016079) 5.782SYT2, SNAP25
regulation of transcription, DNA-templated (GO:0006355) 1.562LRP4, AGRN
regulation of transcription from RNA polymerase II promoter (GO:0006357) 2.242LRP4, AGRN
positive regulation of developmental growth (GO:0048639) 4.672SYT2, AGRN
phosphorylation (GO:0016310) 2.632SURF1, MUSK
(GO:0099003) 5.512SYT2, SNAP25
positive regulation of synaptic transmission (GO:0050806) 5.072RAPSN, SNAP25
modulation of synaptic transmission (GO:0050804) 4.092RAPSN, SNAP25
positive regulation of signaling (GO:0023056) 2.412RAPSN, SNAP25
single-organism carbohydrate metabolic process (GO:0044723) 3.422DPAGT1, ALG2
regulation of secretion by cell (GO:1903530) 3.282SYT2, SNAP25
positive regulation of cell communication (GO:0010647) 2.412RAPSN, SNAP25
anatomical structure morphogenesis (GO:0009653) 2.532COL13A1, LRP4
positive regulation of catalytic activity (GO:0043085) 2.42DOK7, AGRN
regulation of protein localization (GO:0032880) 2.882LRP4, SNAP25
musculoskeletal movement (GO:0050881) 7.242CHRND, CHRNA1
positive regulation of neuromuscular junction development (GO:1904398) 8.632LRP4, AGRN
postsynaptic membrane organization (GO:0001941) 7.652LRP4, CHRNB1
positive regulation of multicellular organismal process (GO:0051240) 2.492SYT2, AGRN
calcium ion regulated exocytosis (GO:0017156) 5.592SYT2, SNAP25
heme metabolic process (GO:0042168) 6.332COX15, COX10
multicellular organismal movement (GO:0050879) 7.242CHRND, CHRNA1
isoprenoid metabolic process (GO:0006720) 4.892DPAGT1, AGRN
respiratory electron transport chain (GO:0022904) 5.112COX15, COX10
regulation of nucleic acid-templated transcription (GO:1903506) 1.552LRP4, AGRN
heme a metabolic process (GO:0046160) 9.042COX15, COX10
positive regulation of developmental process (GO:0051094) 2.772SYT2, AGRN
regulation of RNA metabolic process (GO:0051252) 1.522LRP4, AGRN
mitochondrial electron transport, cytochrome c to oxygen (GO:0006123) 6.732COX15, COX10
positive regulation of gene expression (GO:0010628) 2.352MUSK, AGRN
positive regulation of growth (GO:0045927) 4.252SYT2, AGRN
neuromuscular process (GO:0050905) 5.272CHRND, CHRNA1
protein glycosylation (GO:0006486) 4.22DPAGT1, ALG2
positive regulation of nervous system development (GO:0051962) 3.642SYT2, AGRN
protein tetramerization (GO:0051262) 5.012GFPT1, LRP4
regulation of postsynaptic membrane organization (GO:1901626) 7.782RAPSN, LRP4
extracellular structure organization (GO:0043062) 4.02COL13A1, AGRN
regulation of nucleobase-containing compound metabolic process (GO:0019219) 1.432LRP4, AGRN
glycosylation (GO:0070085) 4.162DPAGT1, ALG2
vesicle localization (GO:0051648) 4.852SYT2, SNAP25
organelle localization (GO:0051640) 3.942SYT2, SNAP25
response to oxygen-containing compound (GO:1901700) 2.572GFPT1, CHAT
single-organism organelle organization (GO:1902589) 2.682SYT2, SNAP25
organelle fusion (GO:0048284) 4.862SYT2, SNAP25
acetylcholine metabolic process (GO:0008291) 8.122COLQ, CHAT
negative regulation of cellular process (GO:0048523) 1.412GFPT1, LRP4

NET-GE enrichment

Term New enriched termICP valueGenes
regulation of membrane potential (GO:0042391) -3.890.01SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
synapse organization (GO:0050808) -4.870.0CHRNA1, LRP4, DOK7, CHAT, CHRNE, AGRN, MUSK
skeletal muscle tissue growth (GO:0048630) -8.120.018CHRND, CHRNA1
cytochrome complex assembly (GO:0017004) -6.40.001SURF1, COX15, COX10
membrane organization (GO:0061024) -3.040.01CHRNA1, SCN4A, RAPSN, CHRNB1, DOK7, SNAP25, LRP4, CHRNE, AGRN, MUSK
muscle system process (GO:0003012) -4.180.006SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
aerobic respiration (GO:0009060) -6.40.015SURF1, COX15, COX10
signaling (GO:0023052) -3.250.031COLQ, CHRNA1, SCN4A, RAPSN, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, CHAT, MUSK
regulation of neurotransmitter levels (GO:0001505) -4.770.016COLQ, SYT2, SNAP25, MUSK, CHAT
synaptic transmission, cholinergic (GO:0007271) -6.20.001CHRNE, RAPSN, MUSK, CHRNB1
localization (GO:0051179) -1.40.001COX15, COLQ, CHRNA1, CHRNE, CHAT, DOK7, SURF1, CHRNB1, SYT2, SNAP25, LRP4, AGRN, CHRND, COX10, SCN4A, MUSK
respiratory chain complex IV assembly (GO:0008535) -6.730.0SURF1, COX15, COX10
neuromuscular synaptic transmission (GO:0007274) -6.430.001CHAT, SNAP25, CHRNB1, CHRNA1
protein N-linked glycosylation (GO:0006487) NEW5.650.005DPAGT1, GFPT1, ALG14, ALG2
dolichol-linked oligosaccharide biosynthetic process (GO:0006488) -7.020.0DPAGT1, GFPT1, ALG14, ALG2
postsynaptic membrane organization (GO:0001941) -7.650.034LRP4, MUSK, CHRNB1
peptidyl-asparagine modification (GO:0018196) NEW6.070.04DPAGT1, GFPT1, ALG14, ALG2
positive regulation of neuron death (GO:1901216) NEW5.520.024RAPSN, MUSK, AGRN
heme a biosynthetic process (GO:0006784) -9.040.001COX15, COX10
regulation of synaptic growth at neuromuscular junction (GO:0008582) -8.120.006MUSK, AGRN
protein N-linked glycosylation via asparagine (GO:0018279) NEW6.090.039DPAGT1, GFPT1, ALG14, ALG2
cellular respiration (GO:0045333) -5.90.009SURF1, COX15, COX10
muscle contraction (GO:0006936) -4.370.002SCN4A, CHRND, CHRNE, CHRNA1, CHRNB1
cation transport (GO:0006812) -3.110.013COX15, CHRNA1, SCN4A, SURF1, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, COX10, MUSK
ion transport (GO:0006811) -2.660.008COX15, CHRNA1, SCN4A, CHRNB1, SURF1, SNAP25, CHRND, CHRNE, COX10
heme a metabolic process (GO:0046160) -9.040.001COX15, COX10
neuromuscular junction development (GO:0007528) -6.260.0CHRNA1, LRP4, DOK7, MUSK, CHRNE, AGRN
ion transmembrane transport (GO:0034220) -3.080.002COX15, CHRNA1, SCN4A, CHRNB1, SURF1, SNAP25, CHRND, CHRNE, COX10, MUSK
single-organism cellular process (GO:0044763) -0.650.004COLQ, SYT2, LRP4, COX15, DPAGT1, CHRND, CHAT, ALG14, RAPSN, DOK7, CHRNA1, ALG2, CHRNE, MUSK, COL13A1, GFPT1, COX10, SCN4A, CHRNB1, SURF1, SNAP25, AGRN
protein localization to membrane (GO:0072657) -3.950.034DOK7, LRP4, SCN4A, AGRN, MUSK
neurotransmitter secretion (GO:0007269) -5.70.039SYT2, SNAP25, MUSK, CHAT
synaptic transmission (GO:0007268) -3.980.0COLQ, CHRNA1, SCN4A, RAPSN, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, CHAT, MUSK
cell-cell signaling (GO:0007267) -3.350.021COLQ, CHRNA1, CHAT, RAPSN, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, SCN4A, MUSK
cell communication (GO:0007154) -3.040.004CHRNA1, RAPSN, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, CHAT
transmembrane transport (GO:0055085) -2.720.046COX15, SCN4A, CHRNB1, SURF1, CHRNA1, CHRND, CHRNE, COX10
single-organism localization (GO:1902578) -2.090.007DOK7, LRP4, MUSK, AGRN
single organism signaling (GO:0044700) -3.250.031COLQ, CHRNA1, CHAT, RAPSN, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, SCN4A, MUSK
single-organism cellular localization (GO:1902580) -3.160.007DOK7, LRP4, AGRN, MUSK
energy derivation by oxidation of organic compounds (GO:0015980) -4.930.002GFPT1, SURF1, COX15, SNAP25, COX10
carbohydrate derivative biosynthetic process (GO:1901137) -3.730.009COX15, ALG14, GFPT1, SNAP25, SURF1, ALG2, DPAGT1, AGRN
mitochondrial electron transport, cytochrome c to oxygen (GO:0006123) -6.730.018COX15, COX10
skeletal muscle acetylcholine-gated channel clustering (GO:0071340) -7.530.014LRP4, MUSK, AGRN
UDP-N-acetylglucosamine metabolic process (GO:0006047) -7.090.043DPAGT1, GFPT1
single-organism membrane organization (GO:0044802) -3.190.0CHRNA1, SCN4A, RAPSN, CHRNB1, DOK7, SNAP25, LRP4, CHRNE, AGRN, MUSK
receptor clustering (GO:0043113) -6.020.007DOK7, LRP4, MUSK, AGRN
cation transmembrane transport (GO:0098655) -3.430.0COX15, CHRNA1, SCN4A, CHRNB1, SURF1, SNAP25, CHRND, CHRNE, COX10, MUSK
positive regulation of neuron apoptotic process (GO:0043525) NEW5.880.015RAPSN, AGRN, MUSK
GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GOICNumber of genes with the same GOGenes
cell part (GO:0044464) 0.1123COLQ, SYT2, LRP4, COX15, DPAGT1, CHRND, CHAT, ALG14, RAPSN, DOK7, CHRNA1, ALG2, CHRNE, MUSK, COL13A1, GFPT1, COX10, SCN4A, TACO1, CHRNB1, SURF1, SNAP25, AGRN
membrane (GO:0016020) 0.6820CHRNA1, COX10, COL13A1, COLQ, ALG14, SCN4A, RAPSN, DOK7, LRP4, CHRNB1, SYT2, SURF1, SNAP25, COX15, DPAGT1, ALG2, CHRNE, CHRND, AGRN, MUSK
membrane part (GO:0044425) 0.9518ALG14, COL13A1, CHRNA1, SCN4A, RAPSN, SURF1, LRP4, CHRNB1, SYT2, COX15, SNAP25, AGRN, DPAGT1, COX10, CHRNE, CHRND, ALG2, MUSK
integral component of membrane (GO:0016021) 1.1416ALG14, COL13A1, CHRNA1, SCN4A, SURF1, LRP4, CHRNB1, SYT2, ALG2, COX15, DPAGT1, COX10, CHRNE, CHRND, AGRN, MUSK
intrinsic component of membrane (GO:0031224) 1.1316COX10, COL13A1, CHRNA1, SCN4A, SURF1, CHRNB1, ALG14, SYT2, LRP4, COX15, DPAGT1, ALG2, CHRNE, CHRND, AGRN, MUSK
intracellular part (GO:0044424) 0.2815COL13A1, ALG14, RAPSN, CHAT, TACO1, SURF1, LRP4, SYT2, COX15, SNAP25, AGRN, DPAGT1, GFPT1, COX10, ALG2
cytoplasmic part (GO:0044444) 0.8214COL13A1, ALG14, RAPSN, CHAT, TACO1, SURF1, SNAP25, SYT2, AGRN, COX15, DPAGT1, GFPT1, COX10, ALG2
organelle (GO:0043226) 0.414COX15, ALG14, RAPSN, CHAT, TACO1, SURF1, LRP4, SYT2, SNAP25, AGRN, DPAGT1, GFPT1, COX10, ALG2
membrane-bounded organelle (GO:0043227) 0.4713COX15, ALG14, RAPSN, CHAT, TACO1, SURF1, SNAP25, SYT2, AGRN, DPAGT1, GFPT1, COX10, ALG2
plasma membrane (GO:0005886) 1.3913COL13A1, COLQ, CHRNA1, RAPSN, DOK7, CHRNB1, SYT2, SNAP25, LRP4, AGRN, CHRND, CHRNE, MUSK
protein complex (GO:0043234) 1.5112COL13A1, COLQ, CHRNA1, SCN4A, CHRNB1, SNAP25, LRP4, COX15, CHRND, COX10, CHRNE, MUSK
macromolecular complex (GO:0032991) 1.3512COL13A1, COLQ, CHRNA1, SCN4A, CHRNB1, SNAP25, LRP4, COX15, CHRND, COX10, CHRNE, MUSK
synapse (GO:0045202) 3.5812COLQ, CHRNA1, RAPSN, DOK7, CHRNB1, SYT2, SNAP25, LRP4, AGRN, CHRND, CHRNE, MUSK
cell junction (GO:0030054) 2.7512COL13A1, COLQ, CHRNA1, RAPSN, DOK7, CHRNB1, SYT2, SNAP25, CHRND, CHRNE, AGRN, MUSK
intracellular organelle (GO:0043229) 0.5111COX15, ALG14, RAPSN, TACO1, SURF1, LRP4, SYT2, CHAT, DPAGT1, COX10, ALG2
synapse part (GO:0044456) 3.4211COLQ, CHRNA1, CHAT, RAPSN, CHRNB1, SYT2, SNAP25, LRP4, CHRND, CHRNE, MUSK
intracellular organelle part (GO:0044446) 0.8110COL13A1, ALG14, SURF1, SNAP25, SYT2, ALG2, COX15, DPAGT1, COX10, AGRN
plasma membrane part (GO:0044459) 1.9510COL13A1, CHRNA1, SCN4A, RAPSN, CHRNB1, SNAP25, LRP4, CHRND, CHRNE, MUSK
intracellular membrane-bounded organelle (GO:0043231) 0.610COX15, TACO1, RAPSN, SURF1, ALG14, SYT2, CHAT, DPAGT1, COX10, ALG2
organelle part (GO:0044422) 0.7910COL13A1, ALG14, SURF1, SNAP25, SYT2, COX10, COX15, DPAGT1, ALG2, AGRN
synaptic membrane (GO:0097060) 4.228CHRNA1, RAPSN, CHRNB1, SNAP25, LRP4, CHRND, CHRNE, MUSK
plasma membrane region (GO:0098590) 2.978CHRNA1, RAPSN, CHRNB1, SNAP25, LRP4, CHRND, CHRNE, MUSK
plasma membrane protein complex (GO:0098797) 3.558COL13A1, CHRNA1, SCN4A, CHRNB1, SNAP25, LRP4, CHRND, CHRNE
membrane protein complex (GO:0098796) 2.848COL13A1, CHRNA1, SCN4A, CHRNB1, SNAP25, LRP4, CHRND, CHRNE
ion channel complex (GO:0034702) 4.186CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE
transporter complex (GO:1990351) 4.046CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE
transmembrane transporter complex (GO:1902495) 4.066CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE
postsynaptic membrane (GO:0045211) 4.476RAPSN, CHRNB1, CHRNA1, CHRND, CHRNE, MUSK
neuromuscular junction (GO:0031594) 5.815LRP4, RAPSN, COLQ, MUSK, CHRNA1
receptor complex (GO:0043235) 4.015CHRND, CHRNE, CHRNB1, MUSK, CHRNA1
organelle membrane (GO:0031090) 1.975SURF1, COX15, SYT2, COX10, ALG14
cytoplasm (GO:0005737) 1.015CHAT, ALG2, RAPSN, SNAP25, AGRN
vesicle (GO:0031982) 1.644SYT2, GFPT1, SNAP25, AGRN
neuron part (GO:0097458) 2.644SYT2, LRP4, SNAP25, CHAT
cytosol (GO:0005829) 1.684SYT2, GFPT1, SNAP25, CHAT
plasma membrane receptor complex (GO:0098802) 4.634CHRND, CHRNE, CHRNA1, CHRNB1
mitochondrion (GO:0005739) 2.424COX15, SURF1, TACO1, COX10
acetylcholine-gated channel complex (GO:0005892) 6.674CHRND, CHRNE, CHRNA1, CHRNB1
endoplasmic reticulum part (GO:0044432) 2.734DPAGT1, COL13A1, ALG14, ALG2
integral component of plasma membrane (GO:0005887) 2.574SCN4A, CHRNE, CHRNB1, MUSK
intrinsic component of plasma membrane (GO:0031226) 2.534SCN4A, CHRNE, CHRNB1, MUSK
nucleus (GO:0005634) 1.074CHAT, TACO1, ALG14, ALG2
endoplasmic reticulum membrane (GO:0005789) 2.953DPAGT1, ALG14, ALG2
organelle inner membrane (GO:0019866) 3.563SURF1, COX15, COX10
mitochondrial membrane (GO:0031966) 3.313SURF1, COX15, COX10
mitochondrial inner membrane (GO:0005743) 3.653SURF1, COX15, COX10
extracellular region (GO:0005576) 2.183COL13A1, COLQ, AGRN
mitochondrial part (GO:0044429) 2.923SURF1, COX15, COX10
neuron projection (GO:0043005) 3.123CHAT, LRP4, SNAP25
membrane-bounded vesicle (GO:0031988) 1.713SYT2, GFPT1, AGRN
cell projection (GO:0042995) 2.473CHAT, LRP4, SNAP25
extracellular region part (GO:0044421) 1.573GFPT1, COLQ, AGRN
basal lamina (GO:0005605) 7.092COLQ, AGRN
extracellular organelle (GO:0043230) 1.892GFPT1, AGRN
endoplasmic reticulum (GO:0005783) 2.562DPAGT1, ALG14
intracellular non-membrane-bounded organelle (GO:0043232) 1.762RAPSN, LRP4
organelle lumen (GO:0043233) 3.052COL13A1, AGRN
extracellular exosome (GO:0070062) 1.892GFPT1, AGRN
cell surface (GO:0009986) 3.442LRP4, CHRNA1
membrane-enclosed lumen (GO:0031974) 3.052COL13A1, AGRN
mitochondrial membrane part (GO:0044455) 4.542SURF1, COX15
intracellular organelle lumen (GO:0070013) 3.052COL13A1, AGRN
Golgi apparatus part (GO:0044431) 3.02SNAP25, AGRN
non-membrane-bounded organelle (GO:0043228) 1.762RAPSN, LRP4
mitochondrial respiratory chain (GO:0005746) 7.162SURF1, COX15
cation channel complex (GO:0034703) 4.692SCN4A, SNAP25
cytochrome complex (GO:0070069) 6.512COX15, COX10
perinuclear region of cytoplasm (GO:0048471) 3.352SNAP25, ALG2
extracellular vesicle (GO:1903561) 1.892GFPT1, AGRN
extracellular matrix component (GO:0044420) 4.972COLQ, AGRN
respiratory chain (GO:0070469) 5.512SURF1, COX15
collagen trimer (GO:0005581) 5.212COL13A1, COLQ

NET-GE enrichment

Term New enriched termICP valueGenes
synaptic membrane (GO:0097060) -4.220.0CHRNA1, RAPSN, CHRNB1, SNAP25, LRP4, CHRND, CHRNE, AGRN, MUSK
acetylcholine-gated channel complex (GO:0005892) -6.670.0CHRND, CHRNE, CHRNA1, CHRNB1
basal lamina (GO:0005605) -7.090.019COLQ, AGRN
transmembrane transporter complex (GO:1902495) -4.060.001CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
receptor complex (GO:0043235) -4.010.001CHRNA1, CHRNB1, SNAP25, CHRND, CHRNE, AGRN, MUSK
integral component of membrane (GO:0016021) -1.140.028CHRNB1, COX15, CHRNA1, CHRNE, SCN4A, SURF1, LRP4, ALG14, SYT2, ALG2, DPAGT1, COX10, CHRND, AGRN, MUSK
transporter complex (GO:1990351) -4.040.002CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
neuromuscular junction (GO:0031594) -5.810.0RAPSN, LRP4, DOK7, CHRNA1, CHRNE, MUSK
postsynaptic membrane (GO:0045211) -4.470.001CHRNA1, RAPSN, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
synapse part (GO:0044456) -3.420.0CHRNA1, RAPSN, CHRNB1, SYT2, SNAP25, LRP4, AGRN, CHRND, CHRNE, MUSK
ion channel complex (GO:0034702) -4.180.001CHRNA1, SCN4A, CHRNB1, SNAP25, CHRND, CHRNE, MUSK
synapse (GO:0045202) -3.580.0COLQ, CHRNA1, RAPSN, CHRNB1, DOK7, SNAP25, LRP4, CHRNE, AGRN, MUSK
membrane part (GO:0044425) -0.950.004CHRNB1, COL13A1, CHRNA1, CHRNE, SCN4A, RAPSN, SURF1, LRP4, ALG14, SYT2, COX15, SNAP25, AGRN, DPAGT1, COX10, CHRND, ALG2, MUSK
mitochondrial respiratory chain (GO:0005746) -7.160.017SURF1, COX15
respiratory chain (GO:0070469) -5.510.042SURF1, COX15
plasma membrane part (GO:0044459) -1.950.015COL13A1, CHRNA1, SCN4A, RAPSN, CHRNB1, SNAP25, LRP4, CHRND, CHRNE, MUSK
cell junction (GO:0030054) -2.750.0COL13A1, COLQ, CHRNA1, SCN4A, RAPSN, DOK7, CHRNB1, SYT2, SNAP25, LRP4, AGRN, CHRND, CHRNE, MUSK