Disease table of AFIBRINOGENEMIA, CONGENITAL OMIM ID: 202400

Gene-disease associations table

Gene	Associated with AFIBRINOGENEMIA, CONGENITAL in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
FGG	OMIM, HUMSAVAR	HGNC link	4q32.1	2	202400, 616004
FGA	OMIM, HUMSAVAR	HGNC link	4q31.3	3	202400, 105200, 616004
FGB	OMIM, HUMSAVAR	HGNC link	4q31.3	2	202400, 616004

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By sub-band

Shared sub_band	Number of genes associated with the disease	Genes associated with the disease
4q31.3	2	FGB, FGA

By band

Shared band	Number of genes associated with the disease	Genes associated with the disease
4q31	2	FGB, FGA

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
4q3	3	FGG, FGB, FGA

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
4q	3	FGG, FGB, FGA

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
4	3	FGG, FGB, FGA

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs
FGG	YES	1	STAT3
FGA	YES	1	TFCP2
FGB	YES	1	FOXM1

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
FGG	FGA	Yes	9	FGA, DDX19B, ASB6, FGG, ASB7, KHDRBS2, FN1, FGB, ALDH2
FGG	FGB	Yes	9	FGA, FN1, ASCC1, ASB6, FGG, ASB7, KHDRBS2, DDX19B, ALDH2
FGA	FGB	Yes	10	FGA, FN1, ASB6, FGG, ASB7, KHDRBS2, DDX19B, NID1, MIS12, ALDH2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
FGG	FGA	Yes	binding	20	ITGB3, ITGAX, ITGB1, SERPINC1, PLAUR, F13A1, PLAU, THBS1, FN1, ITGA2B, F2, ITGA5, ITGAD, SERPINF2, FGL2, ITGAV, FGL1, ITGAM, F13B, FGB
FGG	FGB	Yes	binding	20	FGA, ITGB3, ITGAX, ITGB1, SERPINC1, PLAUR, F13A1, PLAU, THBS1, FN1, ITGA2B, F2, ITGA5, ITGAD, FGL1, FGL2, ITGAV, ITGAM, F13B, SERPINF2
FGA	FGB	Yes	binding	21	ITGB3, ITGAX, ITGB1, SERPINC1, PLAUR, THBS1, PLAU, ITGAM, F13A1, FN1, ITGA2B, F2, ITGA5, ITGAD, FGL1, FGL2, FGG, ITGAV, MIS12, F13B, SERPINF2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Gene1	Gene2	Interaction	Number of common interactors	Common genes in interaction
FGG	FGA	Yes	4	FGA, F2, FGG, FGB
FGG	FGB	Yes	4	FGA, F2, FGG, FGB
FGA	FGB	Yes	4	FGA, F2, FGG, FGB

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from manually curated literature

KEGG pathways annotation: shared terms / NET-GE enrichment

Shared terms

KEGG term	KEGG term ID	IC	Number of genes with the same term	Genes
Platelet activation	hsa04611	5.66	3	FGA, FGG, FGB
Complement and coagulation cascades	hsa04610	6.58	3	FGA, FGG, FGB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Platelet activation (hsa04611)	-	5.66	0.0	FGA, FGG, FGB
Complement and coagulation cascades (hsa04610)	-	6.58	0.0	FGA, FGG, FGB
Immune system	NEW	2.92	0.018	FGA, FGG, FGB

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	R-HSA-2404192	4.85	3	FGA, FGG, FGB
Gastrin-CREB signalling pathway via PKC and MAPK	R-HSA-881907	4.26	3	FGA, FGG, FGB
Signalling to p38 via RIT and RIN	R-HSA-187706	5.12	3	FGA, FGG, FGB
Platelet degranulation	R-HSA-114608	6.68	3	FGA, FGG, FGB
Signaling by Interleukins	R-HSA-449147	4.71	3	FGA, FGG, FGB
Signaling by PDGF	R-HSA-186797	4.53	3	FGA, FGG, FGB
Immune System	R-HSA-168256	2.37	3	FGA, FGG, FGB
Frs2-mediated activation	R-HSA-170968	5.12	3	FGA, FGG, FGB
MAP2K and MAPK activation	R-HSA-5674135	7.66	3	FGA, FGG, FGB
Cytokine Signaling in Immune system	R-HSA-1280215	3.74	3	FGA, FGG, FGB
Extracellular matrix organization	R-HSA-1474244	4.91	3	FGA, FGG, FGB
IGF1R signaling cascade	R-HSA-2428924	4.85	3	FGA, FGG, FGB
Downstream signal transduction	R-HSA-186763	4.65	3	FGA, FGG, FGB
IRS-related events triggered by IGF1R	R-HSA-2428928	4.85	3	FGA, FGG, FGB
Signaling by ERBB4	R-HSA-1236394	4.7	3	FGA, FGG, FGB
Signaling by Insulin receptor	R-HSA-74752	4.73	3	FGA, FGG, FGB
Developmental Biology	R-HSA-1266738	3.48	3	FGA, FGG, FGB
Insulin receptor signalling cascade	R-HSA-74751	4.85	3	FGA, FGG, FGB
Integrin cell surface interactions	R-HSA-216083	6.57	3	FGA, FGG, FGB
Platelet Aggregation (Plug Formation)	R-HSA-76009	7.77	3	FGA, FGG, FGB
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71	3	FGA, FGG, FGB
MAPK family signaling cascades	R-HSA-5683057	4.89	3	FGA, FGG, FGB
Signalling by NGF	R-HSA-166520	4.23	3	FGA, FGG, FGB
Signaling by VEGF	R-HSA-194138	4.66	3	FGA, FGG, FGB
MAPK1/MAPK3 signaling	R-HSA-5684996	5.11	3	FGA, FGG, FGB
Platelet activation, signaling and aggregation	R-HSA-76002	5.15	3	FGA, FGG, FGB
FCERI mediated MAPK activation	R-HSA-2871796	4.32	3	FGA, FGG, FGB
VEGFR2 mediated cell proliferation	R-HSA-5218921	5.07	3	FGA, FGG, FGB
Response to elevated platelet cytosolic Ca2+	R-HSA-76005	6.59	3	FGA, FGG, FGB
IRS-mediated signalling	R-HSA-112399	4.87	3	FGA, FGG, FGB
p130Cas linkage to MAPK signaling for integrins	R-HSA-372708	9.08	3	FGA, FGG, FGB
FRS-mediated FGFR2 signaling	R-HSA-5654700	5.14	3	FGA, FGG, FGB
FRS-mediated FGFR4 signaling	R-HSA-5654712	5.14	3	FGA, FGG, FGB
FRS-mediated FGFR3 signaling	R-HSA-5654706	5.14	3	FGA, FGG, FGB
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71	3	FGA, FGG, FGB
RAF/MAP kinase cascade	R-HSA-5673001	5.15	3	FGA, FGG, FGB
Signaling by FGFR4	R-HSA-5654743	4.69	3	FGA, FGG, FGB
Signaling by FGFR3	R-HSA-5654741	4.69	3	FGA, FGG, FGB
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7	3	FGA, FGG, FGB
Signaling by FGFR	R-HSA-190236	4.67	3	FGA, FGG, FGB
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03	3	FGA, FGG, FGB
GRB2 events in ERBB2 signaling	R-HSA-1963640	5.15	3	FGA, FGG, FGB
Interleukin receptor SHC signaling	R-HSA-912526	5.09	3	FGA, FGG, FGB
Innate Immune System	R-HSA-168249	3.17	3	FGA, FGG, FGB
Signaling by SCF-KIT	R-HSA-1433557	4.73	3	FGA, FGG, FGB
Interleukin-2 signaling	R-HSA-451927	5.05	3	FGA, FGG, FGB
NCAM signaling for neurite out-growth	R-HSA-375165	4.9	3	FGA, FGG, FGB
Signalling to RAS	R-HSA-167044	5.08	3	FGA, FGG, FGB
DAP12 signaling	R-HSA-2424491	4.64	3	FGA, FGG, FGB
Interleukin-3, 5 and GM-CSF signaling	R-HSA-512988	4.99	3	FGA, FGG, FGB
SOS-mediated signalling	R-HSA-112412	5.15	3	FGA, FGG, FGB
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71	3	FGA, FGG, FGB
SHC1 events in ERBB4 signaling	R-HSA-1250347	5.15	3	FGA, FGG, FGB
SHC1 events in EGFR signaling	R-HSA-180336	5.15	3	FGA, FGG, FGB
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51	3	FGA, FGG, FGB
FRS-mediated FGFR1 signaling	R-HSA-5654693	5.14	3	FGA, FGG, FGB
Prolonged ERK activation events	R-HSA-169893	5.11	3	FGA, FGG, FGB
Signalling to ERKs	R-HSA-187687	5.04	3	FGA, FGG, FGB
Signaling by Leptin	R-HSA-2586552	5.1	3	FGA, FGG, FGB
Signaling by GPCR	R-HSA-372790	2.68	3	FGA, FGG, FGB
Signaling by FGFR2	R-HSA-5654738	4.68	3	FGA, FGG, FGB
GRB2 events in EGFR signaling	R-HSA-179812	5.15	3	FGA, FGG, FGB
SHC1 events in ERBB2 signaling	R-HSA-1250196	5.15	3	FGA, FGG, FGB
Signaling by FGFR1	R-HSA-5654736	4.69	3	FGA, FGG, FGB
Signaling by EGFR	R-HSA-177929	4.59	3	FGA, FGG, FGB
ARMS-mediated activation	R-HSA-170984	5.12	3	FGA, FGG, FGB
GRB2:SOS provides linkage to MAPK signaling for Integrins	R-HSA-354194	9.08	3	FGA, FGG, FGB
DAP12 interactions	R-HSA-2172127	4.56	3	FGA, FGG, FGB
Signal Transduction	R-HSA-162582	1.78	3	FGA, FGG, FGB
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71	3	FGA, FGG, FGB
Signaling by ERBB2	R-HSA-1227986	4.66	3	FGA, FGG, FGB
Common Pathway of Fibrin Clot Formation	R-HSA-140875	8.52	3	FGA, FGG, FGB
Axon guidance	R-HSA-422475	3.93	3	FGA, FGG, FGB
Formation of Fibrin Clot (Clotting Cascade)	R-HSA-140877	7.7	3	FGA, FGG, FGB
Hemostasis	R-HSA-109582	3.98	3	FGA, FGG, FGB
Integrin alphaIIb beta3 signaling	R-HSA-354192	8.23	3	FGA, FGG, FGB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (R-HSA-2404192)	-	4.85	0.003	FGA, FGG, FGB
Gastrin-CREB signalling pathway via PKC and MAPK (R-HSA-881907)	-	4.26	0.011	FGA, FGG, FGB
NCAM signaling for neurite out-growth (R-HSA-375165)	-	4.9	0.019	FGA, FGG, FGB
Platelet degranulation (R-HSA-114608)	-	6.68	0.0	FGA, FGG, FGB
Signaling by Interleukins (R-HSA-449147)	-	4.71	0.004	FGA, FGG, FGB
Interleukin-2 signaling (R-HSA-451927)	-	5.05	0.002	FGA, FGG, FGB
Frs2-mediated activation (R-HSA-170968)	-	5.12	0.01	FGA, FGG, FGB
MAP2K and MAPK activation (R-HSA-5674135)	-	7.66	0.0	FGA, FGG, FGB
SHC1 events in ERBB4 signaling (R-HSA-1250347)	-	5.15	0.01	FGA, FGG, FGB
Extracellular matrix organization (R-HSA-1474244)	-	4.91	0.003	FGA, FGG, FGB
IGF1R signaling cascade (R-HSA-2428924)	-	4.85	0.003	FGA, FGG, FGB
Downstream signal transduction (R-HSA-186763)	-	4.65	0.005	FGA, FGG, FGB
IRS-related events triggered by IGF1R (R-HSA-2428928)	-	4.85	0.003	FGA, FGG, FGB
Signaling by ERBB4 (R-HSA-1236394)	-	4.7	0.029	FGA, FGG, FGB
MAPK1/MAPK3 signaling (R-HSA-5684996)	-	5.11	0.01	FGA, FGG, FGB
RAF/MAP kinase cascade (R-HSA-5673001)	-	5.15	0.01	FGA, FGG, FGB
Integrin cell surface interactions (R-HSA-216083)	-	6.57	0.0	FGA, FGG, FGB
Platelet Aggregation (Plug Formation) (R-HSA-76009)	-	7.77	0.0	FGA, FGG, FGB
Downstream signaling of activated FGFR1 (R-HSA-5654687)	-	4.71	0.004	FGA, FGG, FGB
MAPK family signaling cascades (R-HSA-5683057)	-	4.89	0.018	FGA, FGG, FGB
Signalling by NGF (R-HSA-166520)	-	4.23	0.012	FGA, FGG, FGB
Signaling by VEGF (R-HSA-194138)	-	4.66	0.031	FGA, FGG, FGB
Signalling to p38 via RIT and RIN (R-HSA-187706)	-	5.12	0.002	FGA, FGG, FGB
Platelet activation, signaling and aggregation (R-HSA-76002)	-	5.15	0.014	FGA, FGG, FGB
FCERI mediated MAPK activation (R-HSA-2871796)	-	4.32	0.01	FGA, FGG, FGB
VEGFR2 mediated cell proliferation (R-HSA-5218921)	-	5.07	0.011	FGA, FGG, FGB
Response to elevated platelet cytosolic Ca2+ (R-HSA-76005)	-	6.59	0.0	FGA, FGG, FGB
IRS-mediated signalling (R-HSA-112399)	-	4.87	0.02	FGA, FGG, FGB
p130Cas linkage to MAPK signaling for integrins (R-HSA-372708)	-	9.08	0.0	FGA, FGG, FGB
FRS-mediated FGFR2 signaling (R-HSA-5654700)	-	5.14	0.002	FGA, FGG, FGB
SOS-mediated signalling (R-HSA-112412)	-	5.15	0.01	FGA, FGG, FGB
FRS-mediated FGFR3 signaling (R-HSA-5654706)	-	5.14	0.002	FGA, FGG, FGB
Signaling by Insulin receptor (R-HSA-74752)	-	4.73	0.004	FGA, FGG, FGB
Downstream signaling of activated FGFR3 (R-HSA-5654708)	-	4.71	0.004	FGA, FGG, FGB
Insulin receptor signalling cascade (R-HSA-74751)	-	4.85	0.021	FGA, FGG, FGB
Signaling by FGFR4 (R-HSA-5654743)	-	4.69	0.005	FGA, FGG, FGB
Signaling by FGFR3 (R-HSA-5654741)	-	4.69	0.005	FGA, FGG, FGB
VEGFA-VEGFR2 Pathway (R-HSA-4420097)	-	4.7	0.027	FGA, FGG, FGB
GRB2 events in ERBB2 signaling (R-HSA-1963640)	-	5.15	0.01	FGA, FGG, FGB
Signaling by FGFR (R-HSA-190236)	-	4.67	0.005	FGA, FGG, FGB
Fc epsilon receptor (FCERI) signaling (R-HSA-2454202)	-	4.03	0.018	FGA, FGG, FGB
Signaling by Leptin (R-HSA-2586552)	-	5.1	0.01	FGA, FGG, FGB
Interleukin receptor SHC signaling (R-HSA-912526)	-	5.09	0.002	FGA, FGG, FGB
Signaling by SCF-KIT (R-HSA-1433557)	-	4.73	0.004	FGA, FGG, FGB
SHC1 events in ERBB2 signaling (R-HSA-1250196)	-	5.15	0.01	FGA, FGG, FGB
Signaling by PDGF (R-HSA-186797)	-	4.53	0.047	FGA, FGG, FGB
Signalling to RAS (R-HSA-167044)	-	5.08	0.002	FGA, FGG, FGB
DAP12 signaling (R-HSA-2424491)	-	4.64	0.031	FGA, FGG, FGB
SHC1 events in EGFR signaling (R-HSA-180336)	-	5.15	0.01	FGA, FGG, FGB
Interleukin-3, 5 and GM-CSF signaling (R-HSA-512988)	-	4.99	0.012	FGA, FGG, FGB
Downstream signaling of activated FGFR2 (R-HSA-5654696)	-	4.71	0.004	FGA, FGG, FGB
Signaling by FGFR1 (R-HSA-5654736)	-	4.69	0.005	FGA, FGG, FGB
Signaling by EGFR (R-HSA-177929)	-	4.59	0.006	FGA, FGG, FGB
NGF signalling via TRKA from the plasma membrane (R-HSA-187037)	-	4.51	0.007	FGA, FGG, FGB
FRS-mediated FGFR1 signaling (R-HSA-5654693)	-	5.14	0.002	FGA, FGG, FGB
Prolonged ERK activation events (R-HSA-169893)	-	5.11	0.01	FGA, FGG, FGB
Cytokine Signaling in Immune system (R-HSA-1280215)	-	3.74	0.033	FGA, FGG, FGB
FRS-mediated FGFR4 signaling (R-HSA-5654712)	-	5.14	0.002	FGA, FGG, FGB
Signaling by FGFR2 (R-HSA-5654738)	-	4.68	0.03	FGA, FGG, FGB
GRB2 events in EGFR signaling (R-HSA-179812)	-	5.15	0.01	FGA, FGG, FGB
Signalling to ERKs (R-HSA-187687)	-	5.04	0.012	FGA, FGG, FGB
Integrin alphaIIb beta3 signaling (R-HSA-354192)	-	8.23	0.0	FGA, FGG, FGB
ARMS-mediated activation (R-HSA-170984)	-	5.12	0.01	FGA, FGG, FGB
GRB2:SOS provides linkage to MAPK signaling for Integrins (R-HSA-354194)	-	9.08	0.0	FGA, FGG, FGB
DAP12 interactions (R-HSA-2172127)	-	4.56	0.006	FGA, FGG, FGB
Downstream signaling of activated FGFR4 (R-HSA-5654716)	-	4.71	0.004	FGA, FGG, FGB
Signaling by ERBB2 (R-HSA-1227986)	-	4.66	0.032	FGA, FGG, FGB
Common Pathway of Fibrin Clot Formation (R-HSA-140875)	-	8.52	0.0	FGA, FGG, FGB
Axon guidance (R-HSA-422475)	-	3.93	0.022	FGA, FGG, FGB
Formation of Fibrin Clot (Clotting Cascade) (R-HSA-140877)	-	7.7	0.0	FGA, FGG, FGB
Hemostasis (R-HSA-109582)	-	3.98	0.02	FGA, FGG, FGB

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
protein binding, bridging (GO:0030674)	4.68	3	FGA, FGG, FGB
structural molecule activity (GO:0005198)	3.1	3	FGA, FGG, FGB
binding (GO:0005488)	0.18	3	FGA, FGG, FGB
protein binding (GO:0005515)	0.46	3	FGA, FGG, FGB
receptor binding (GO:0005102)	2.43	3	FGA, FGG, FGB
cell adhesion molecule binding (GO:0050839)	4.5	3	FGA, FGG, FGB
binding, bridging (GO:0060090)	4.57	3	FGA, FGG, FGB
cation binding (GO:0043169)	1.4	2	FGA, FGG
metal ion binding (GO:0046872)	1.41	2	FGA, FGG
ion binding (GO:0043167)	1.36	2	FGA, FGG

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
protein binding, bridging (GO:0030674)	-	4.68	0.0	FGA, FGG, FGB
chaperone binding (GO:0051087)	NEW	5.34	0.008	FGA, FGB
vitamin binding (GO:0019842)	NEW	5.34	0.033	FGA, FGG
structural molecule activity (GO:0005198)	-	3.1	0.001	FGA, FGG, FGB
steroid binding (GO:0005496)	NEW	5.24	0.04	FGA, FGG
binding, bridging (GO:0060090)	-	4.57	0.001	FGA, FGG, FGB

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
regulation of peptide transport (GO:0090087)	4.37	3	FGA, FGG, FGB
positive regulation of heterotypic cell-cell adhesion (GO:0034116)	7.43	3	FGA, FGG, FGB
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	4.69	3	FGA, FGG, FGB
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	5.13	3	FGA, FGG, FGB
regulation of phosphate metabolic process (GO:0019220)	2.35	3	FGA, FGG, FGB
regulation of primary metabolic process (GO:0080090)	1.08	3	FGA, FGG, FGB
regulation of secretion (GO:0051046)	3.2	3	FGA, FGG, FGB
regulation of apoptotic signaling pathway (GO:2001233)	3.83	3	FGA, FGG, FGB
regulation of transport (GO:0051049)	2.24	3	FGA, FGG, FGB
negative regulation of response to stimulus (GO:0048585)	2.52	3	FGA, FGG, FGB
blood coagulation (GO:0007596)	4.52	3	FGA, FGG, FGB
regulation of response to stimulus (GO:0048583)	1.54	3	FGA, FGG, FGB
regulation of vasoconstriction (GO:0019229)	5.51	3	FGA, FGG, FGB
cell-matrix adhesion (GO:0007160)	5.13	3	FGA, FGG, FGB
regulation of heterotypic cell-cell adhesion (GO:0034114)	6.84	3	FGA, FGG, FGB
signal transduction (GO:0007165)	1.28	3	FGA, FGG, FGB
vascular process in circulatory system (GO:0003018)	4.65	3	FGA, FGG, FGB
hemostasis (GO:0007599)	4.5	3	FGA, FGG, FGB
regulation of anatomical structure size (GO:0090066)	3.78	3	FGA, FGG, FGB
cellular component organization or biogenesis (GO:0071840)	1.22	3	FGA, FGG, FGB
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	3	FGA, FGG, FGB
negative regulation of signal transduction (GO:0009968)	2.75	3	FGA, FGG, FGB
positive regulation of cell adhesion (GO:0045785)	3.79	3	FGA, FGG, FGB
regulation of signal transduction (GO:0009966)	1.84	3	FGA, FGG, FGB
positive regulation of signal transduction (GO:0009967)	2.5	3	FGA, FGG, FGB
positive regulation of secretion (GO:0051047)	3.85	3	FGA, FGG, FGB
regulation of hemostasis (GO:1900046)	5.26	3	FGA, FGG, FGB
positive regulation of cell development (GO:0010720)	3.57	3	FGA, FGG, FGB
positive regulation of biological process (GO:0048518)	1.2	3	FGA, FGG, FGB
negative regulation of biological process (GO:0048519)	1.33	3	FGA, FGG, FGB
cell-substrate adhesion (GO:0031589)	4.75	3	FGA, FGG, FGB
positive regulation of response to stimulus (GO:0048584)	2.18	3	FGA, FGG, FGB
positive regulation of transport (GO:0051050)	2.9	3	FGA, FGG, FGB
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	FGA, FGG, FGB
negative regulation of cell death (GO:0060548)	2.95	3	FGA, FGG, FGB
response to calcium ion (GO:0051592)	4.98	3	FGA, FGG, FGB
regulation of peptide hormone secretion (GO:0090276)	4.41	3	FGA, FGG, FGB
positive regulation of peptide hormone secretion (GO:0090277)	5.26	3	FGA, FGG, FGB
response to metal ion (GO:0010038)	3.91	3	FGA, FGG, FGB
response to inorganic substance (GO:0010035)	3.56	3	FGA, FGG, FGB
platelet activation (GO:0030168)	4.96	3	FGA, FGG, FGB
system process (GO:0003008)	2.3	3	FGA, FGG, FGB
regulation of phosphorylation (GO:0042325)	2.5	3	FGA, FGG, FGB
positive regulation of phosphorylation (GO:0042327)	2.9	3	FGA, FGG, FGB
vesicle-mediated transport (GO:0016192)	2.72	3	FGA, FGG, FGB
single-multicellular organism process (GO:0044707)	1.78	3	FGA, FGG, FGB
protein metabolic process (GO:0019538)	1.45	3	FGA, FGG, FGB
positive regulation of cell-substrate adhesion (GO:0010811)	5.11	3	FGA, FGG, FGB
extracellular matrix organization (GO:0030198)	4.01	3	FGA, FGG, FGB
regulation of blood coagulation (GO:0030193)	5.26	3	FGA, FGG, FGB
negative regulation of blood coagulation (GO:0030195)	5.88	3	FGA, FGG, FGB
regulation of secretion by cell (GO:1903530)	3.28	3	FGA, FGG, FGB
regulation of cell morphogenesis (GO:0022604)	3.4	3	FGA, FGG, FGB
positive regulation of cellular component organization (GO:0051130)	2.68	3	FGA, FGG, FGB
cellular component assembly (GO:0022607)	2.14	3	FGA, FGG, FGB
positive regulation of metabolic process (GO:0009893)	1.74	3	FGA, FGG, FGB
regulation of anatomical structure morphogenesis (GO:0022603)	2.79	3	FGA, FGG, FGB
positive regulation of secretion by cell (GO:1903532)	3.93	3	FGA, FGG, FGB
secretion by cell (GO:0032940)	3.59	3	FGA, FGG, FGB
positive regulation of protein transport (GO:0051222)	3.61	3	FGA, FGG, FGB
regulation of protein transport (GO:0051223)	3.12	3	FGA, FGG, FGB
regulation of apoptotic process (GO:0042981)	2.5	3	FGA, FGG, FGB
regulation of biological process (GO:0050789)	0.45	3	FGA, FGG, FGB
regulation of cell communication (GO:0010646)	1.73	3	FGA, FGG, FGB
regulation of protein secretion (GO:0050708)	3.77	3	FGA, FGG, FGB
exocytosis (GO:0006887)	4.11	3	FGA, FGG, FGB
cellular component organization (GO:0016043)	1.24	3	FGA, FGG, FGB
regulated exocytosis (GO:0045055)	4.44	3	FGA, FGG, FGB
macromolecular complex assembly (GO:0065003)	2.55	3	FGA, FGG, FGB
cell-cell adhesion (GO:0098609)	3.34	3	FGA, FGG, FGB
negative regulation of apoptotic signaling pathway (GO:2001234)	4.42	3	FGA, FGG, FGB
negative regulation of hemostasis (GO:1900047)	5.88	3	FGA, FGG, FGB
biological regulation (GO:0065007)	0.39	3	FGA, FGG, FGB
negative regulation of epithelial cell apoptotic process (GO:1904036)	6.15	3	FGA, FGG, FGB
regulation of biological quality (GO:0065008)	1.68	3	FGA, FGG, FGB
regulation of tube size (GO:0035150)	4.79	3	FGA, FGG, FGB
regulation of establishment of protein localization (GO:0070201)	3.02	3	FGA, FGG, FGB
single organism cell adhesion (GO:0098602)	3.63	3	FGA, FGG, FGB
regulation of developmental process (GO:0050793)	2.1	3	FGA, FGG, FGB
transport (GO:0006810)	1.51	3	FGA, FGG, FGB
regulation of cellular process (GO:0050794)	0.5	3	FGA, FGG, FGB
positive regulation of vasoconstriction (GO:0045907)	6.12	3	FGA, FGG, FGB
positive regulation of blood circulation (GO:1903524)	5.16	3	FGA, FGG, FGB
coagulation (GO:0050817)	4.51	3	FGA, FGG, FGB
regulation of blood circulation (GO:1903522)	4.05	3	FGA, FGG, FGB
metabolic process (GO:0008152)	0.58	3	FGA, FGG, FGB
positive regulation of intracellular signal transduction (GO:1902533)	2.95	3	FGA, FGG, FGB
regulation of intracellular signal transduction (GO:1902531)	2.31	3	FGA, FGG, FGB
regulation of coagulation (GO:0050818)	5.22	3	FGA, FGG, FGB
negative regulation of coagulation (GO:0050819)	5.82	3	FGA, FGG, FGB
positive regulation of MAPK cascade (GO:0043410)	3.57	3	FGA, FGG, FGB
fibrinolysis (GO:0042730)	6.68	3	FGA, FGG, FGB
protein maturation (GO:0051604)	4.48	3	FGA, FGG, FGB
positive regulation of protein secretion (GO:0050714)	4.39	3	FGA, FGG, FGB
regulation of response to stress (GO:0080134)	2.53	3	FGA, FGG, FGB
positive regulation of protein modification process (GO:0031401)	2.7	3	FGA, FGG, FGB
cell activation (GO:0001775)	3.47	3	FGA, FGG, FGB
positive regulation of multicellular organismal process (GO:0051240)	2.49	3	FGA, FGG, FGB
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	6.2	3	FGA, FGG, FGB
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	5.72	3	FGA, FGG, FGB
negative regulation of response to external stimulus (GO:0032102)	4.18	3	FGA, FGG, FGB
regulation of multicellular organismal process (GO:0051239)	1.87	3	FGA, FGG, FGB
regulation of response to external stimulus (GO:0032101)	3.06	3	FGA, FGG, FGB
response to stimulus (GO:0050896)	1.22	3	FGA, FGG, FGB
regulation of cell adhesion (GO:0030155)	3.27	3	FGA, FGG, FGB
regulation of cellular component organization (GO:0051128)	2.01	3	FGA, FGG, FGB
positive regulation of signaling (GO:0023056)	2.41	3	FGA, FGG, FGB
negative regulation of signaling (GO:0023057)	2.65	3	FGA, FGG, FGB
regulation of phosphorus metabolic process (GO:0051174)	2.35	3	FGA, FGG, FGB
negative regulation of cell communication (GO:0010648)	2.66	3	FGA, FGG, FGB
regulation of signaling (GO:0023051)	1.72	3	FGA, FGG, FGB
positive regulation of cell communication (GO:0010647)	2.41	3	FGA, FGG, FGB
positive regulation of establishment of protein localization (GO:1904951)	3.49	3	FGA, FGG, FGB
single-organism process (GO:0044699)	0.48	3	FGA, FGG, FGB
regulation of protein localization (GO:0032880)	2.88	3	FGA, FGG, FGB
regulation of blood vessel size (GO:0050880)	4.8	3	FGA, FGG, FGB
regulation of system process (GO:0044057)	3.53	3	FGA, FGG, FGB
positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)	6.4	3	FGA, FGG, FGB
regulation of substrate adhesion-dependent cell spreading (GO:1900024)	5.99	3	FGA, FGG, FGB
negative regulation of multicellular organismal process (GO:0051241)	2.84	3	FGA, FGG, FGB
regulation of protein metabolic process (GO:0051246)	1.93	3	FGA, FGG, FGB
positive regulation of protein metabolic process (GO:0051247)	2.43	3	FGA, FGG, FGB
regulation of cell development (GO:0060284)	3.01	3	FGA, FGG, FGB
regulation of cell morphogenesis involved in differentiation (GO:0010769)	3.91	3	FGA, FGG, FGB
positive regulation of cellular protein metabolic process (GO:0032270)	2.49	3	FGA, FGG, FGB
regulation of protein modification process (GO:0031399)	2.32	3	FGA, FGG, FGB
proteolysis (GO:0006508)	2.73	3	FGA, FGG, FGB
biological adhesion (GO:0022610)	2.81	3	FGA, FGG, FGB
regulation of response to wounding (GO:1903034)	4.74	3	FGA, FGG, FGB
negative regulation of response to wounding (GO:1903035)	5.54	3	FGA, FGG, FGB
regulation of exocytosis (GO:0017157)	4.59	3	FGA, FGG, FGB
multicellular organismal process (GO:0032501)	1.45	3	FGA, FGG, FGB
regulation of body fluid levels (GO:0050878)	3.76	3	FGA, FGG, FGB
cellular process (GO:0009987)	0.26	3	FGA, FGG, FGB
regulation of endothelial cell apoptotic process (GO:2000351)	5.99	3	FGA, FGG, FGB
negative regulation of endothelial cell apoptotic process (GO:2000352)	6.43	3	FGA, FGG, FGB
regulation of vesicle-mediated transport (GO:0060627)	3.63	3	FGA, FGG, FGB
positive regulation of cell differentiation (GO:0045597)	3.01	3	FGA, FGG, FGB
regulation of cell differentiation (GO:0045595)	2.42	3	FGA, FGG, FGB
regulation of MAPK cascade (GO:0043408)	3.22	3	FGA, FGG, FGB
positive regulation of hormone secretion (GO:0046887)	4.98	3	FGA, FGG, FGB
protein processing (GO:0016485)	4.62	3	FGA, FGG, FGB
regulation of localization (GO:0032879)	1.94	3	FGA, FGG, FGB
protein polymerization (GO:0051258)	5.8	3	FGA, FGG, FGB
regulation of cellular protein metabolic process (GO:0032268)	1.99	3	FGA, FGG, FGB
protein complex assembly (GO:0006461)	2.78	3	FGA, FGG, FGB
positive regulation of developmental process (GO:0051094)	2.77	3	FGA, FGG, FGB
macromolecule metabolic process (GO:0043170)	0.83	3	FGA, FGG, FGB
regulation of peptide secretion (GO:0002791)	4.38	3	FGA, FGG, FGB
positive regulation of cell morphogenesis involved in differentiation (GO:0010770)	4.65	3	FGA, FGG, FGB
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	4.56	3	FGA, FGG, FGB
regulation of ERK1 and ERK2 cascade (GO:0070372)	4.23	3	FGA, FGG, FGB
positive regulation of exocytosis (GO:0045921)	5.41	3	FGA, FGG, FGB
single organismal cell-cell adhesion (GO:0016337)	3.69	3	FGA, FGG, FGB
macromolecular complex subunit organization (GO:0043933)	2.14	3	FGA, FGG, FGB
positive regulation of cellular metabolic process (GO:0031325)	1.81	3	FGA, FGG, FGB
regulation of cellular metabolic process (GO:0031323)	1.07	3	FGA, FGG, FGB
regulation of cell-cell adhesion (GO:0022407)	3.79	3	FGA, FGG, FGB
regulation of wound healing (GO:0061041)	4.88	3	FGA, FGG, FGB
negative regulation of wound healing (GO:0061045)	5.65	3	FGA, FGG, FGB
cellular macromolecular complex assembly (GO:0034622)	3.18	3	FGA, FGG, FGB
establishment of localization (GO:0051234)	1.48	3	FGA, FGG, FGB
regulation of cell death (GO:0010941)	2.43	3	FGA, FGG, FGB
positive regulation of cell-cell adhesion (GO:0022409)	4.23	3	FGA, FGG, FGB
protein complex subunit organization (GO:0071822)	2.6	3	FGA, FGG, FGB
protein activation cascade (GO:0072376)	5.21	3	FGA, FGG, FGB
blood coagulation, fibrin clot formation (GO:0072378)	8.34	3	FGA, FGG, FGB
platelet degranulation (GO:0002576)	5.12	3	FGA, FGG, FGB
plasminogen activation (GO:0031639)	7.53	3	FGA, FGG, FGB
zymogen activation (GO:0031638)	6.33	3	FGA, FGG, FGB
organic substance metabolic process (GO:0071704)	0.63	3	FGA, FGG, FGB
regulation of programmed cell death (GO:0043067)	2.49	3	FGA, FGG, FGB
negative regulation of apoptotic process (GO:0043066)	3.04	3	FGA, FGG, FGB
extracellular structure organization (GO:0043062)	4.0	3	FGA, FGG, FGB
negative regulation of programmed cell death (GO:0043069)	3.02	3	FGA, FGG, FGB
regulation of epithelial cell apoptotic process (GO:1904035)	5.63	3	FGA, FGG, FGB
positive regulation of phosphate metabolic process (GO:0045937)	2.78	3	FGA, FGG, FGB
regulation of cell-substrate adhesion (GO:0010810)	4.56	3	FGA, FGG, FGB
homotypic cell-cell adhesion (GO:0034109)	5.76	3	FGA, FGG, FGB
positive regulation of phosphorus metabolic process (GO:0010562)	2.78	3	FGA, FGG, FGB
regulation of hormone levels (GO:0010817)	3.56	3	FGA, FGG, FGB
circulatory system process (GO:0003013)	4.38	3	FGA, FGG, FGB
single-organism transport (GO:0044765)	2.18	3	FGA, FGG, FGB
single-organism cellular process (GO:0044763)	0.65	3	FGA, FGG, FGB
cell adhesion (GO:0007155)	2.82	3	FGA, FGG, FGB
response to chemical (GO:0042221)	1.98	3	FGA, FGG, FGB
regulation of metabolic process (GO:0019222)	1.02	3	FGA, FGG, FGB
cellular protein complex assembly (GO:0043623)	3.9	3	FGA, FGG, FGB
localization (GO:0051179)	1.4	3	FGA, FGG, FGB
single-organism localization (GO:1902578)	2.09	3	FGA, FGG, FGB
primary metabolic process (GO:0044238)	0.69	3	FGA, FGG, FGB
secretion (GO:0046903)	3.38	3	FGA, FGG, FGB
positive regulation of peptide secretion (GO:0002793)	5.22	3	FGA, FGG, FGB
positive regulation of protein phosphorylation (GO:0001934)	2.95	3	FGA, FGG, FGB
regulation of hormone secretion (GO:0046883)	4.18	3	FGA, FGG, FGB
regulation of protein phosphorylation (GO:0001932)	2.57	3	FGA, FGG, FGB
platelet aggregation (GO:0070527)	6.04	3	FGA, FGG, FGB
negative regulation of cellular process (GO:0048523)	1.41	3	FGA, FGG, FGB
positive regulation of cellular process (GO:0048522)	1.3	3	FGA, FGG, FGB
antimicrobial humoral response (GO:0019730)	5.92	2	FGA, FGB
antibacterial humoral response (GO:0019731)	6.02	2	FGA, FGB
defense response to bacterium (GO:0042742)	4.31	2	FGA, FGB
cellular response to chemical stimulus (GO:0070887)	2.57	2	FGA, FGB
response to endogenous stimulus (GO:0009719)	2.79	2	FGA, FGB
cellular response to stimulus (GO:0051716)	1.97	2	FGA, FGB
response to external biotic stimulus (GO:0043207)	3.13	2	FGA, FGB
response to bacterium (GO:0009617)	4.18	2	FGA, FGB
cellular response to organic substance (GO:0071310)	2.78	2	FGA, FGB
response to cytokine (GO:0034097)	3.84	2	FGA, FGB
innate immune response (GO:0045087)	3.55	2	FGA, FGB
defense response (GO:0006952)	2.78	2	FGA, FGB
response to stress (GO:0006950)	1.8	2	FGA, FGB
defense response to other organism (GO:0098542)	3.75	2	FGA, FGB
immune response (GO:0006955)	2.86	2	FGA, FGB
humoral immune response (GO:0006959)	4.59	2	FGA, FGB
response to other organism (GO:0051707)	3.48	2	FGA, FGB
response to organic substance (GO:0010033)	2.2	2	FGA, FGB
multi-organism process (GO:0051704)	2.65	2	FGA, FGB
response to biotic stimulus (GO:0009607)	3.09	2	FGA, FGB
response to external stimulus (GO:0009605)	2.55	2	FGA, FGB
cellular response to cytokine stimulus (GO:0071345)	4.33	2	FGA, FGB
immune system process (GO:0002376)	2.29	2	FGA, FGB
adaptive immune response (GO:0002250)	4.43	2	FGA, FGB
induction of bacterial agglutination (GO:0043152)	8.34	2	FGA, FGB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
regulation of peptide transport (GO:0090087)	-	4.37	0.0	FGA, FGG, FGB
positive regulation of heterotypic cell-cell adhesion (GO:0034116)	-	7.43	0.0	FGA, FGG, FGB
regulation of extrinsic apoptotic signaling pathway (GO:2001236)	-	4.69	0.008	FGA, FGG, FGB
regulation of heterotypic cell-cell adhesion (GO:0034114)	-	6.84	0.0	FGA, FGG, FGB
hemostasis (GO:0007599)	-	4.5	0.003	FGA, FGG, FGB
regulation of secretion (GO:0051046)	-	3.2	0.005	FGA, FGG, FGB
positive regulation of secretion (GO:0051047)	-	3.85	0.001	FGA, FGG, FGB
negative regulation of response to stimulus (GO:0048585)	-	2.52	0.036	FGA, FGG, FGB
blood coagulation (GO:0007596)	-	4.52	0.003	FGA, FGG, FGB
regulation of vasoconstriction (GO:0019229)	-	5.51	0.0	FGA, FGG, FGB
cell-matrix adhesion (GO:0007160)	-	5.13	0.002	FGA, FGG, FGB
negative regulation of extrinsic apoptotic signaling pathway (GO:2001237)	-	5.13	0.0	FGA, FGG, FGB
response to leptin (GO:0044321)	NEW	6.84	0.004	FGA, FGB
cellular response to leptin stimulus (GO:0044320)	NEW	7.53	0.003	FGA, FGB
negative regulation of signal transduction (GO:0009968)	-	2.75	0.021	FGA, FGG, FGB
positive regulation of cell adhesion (GO:0045785)	-	3.79	0.012	FGA, FGG, FGB
positive regulation of signal transduction (GO:0009967)	-	2.5	0.035	FGA, FGG, FGB
regulation of apoptotic signaling pathway (GO:2001233)	-	3.83	0.001	FGA, FGG, FGB
positive regulation of cell development (GO:0010720)	-	3.57	0.041	FGA, FGG, FGB
cell-substrate adhesion (GO:0031589)	-	4.75	0.005	FGA, FGG, FGB
positive regulation of transport (GO:0051050)	-	2.9	0.008	FGA, FGG, FGB
negative regulation of cell death (GO:0060548)	-	2.95	0.012	FGA, FGG, FGB
response to calcium ion (GO:0051592)	-	4.98	0.0	FGA, FGG, FGB
regulation of peptide hormone secretion (GO:0090276)	-	4.41	0.0	FGA, FGG, FGB
positive regulation of peptide hormone secretion (GO:0090277)	-	5.26	0.0	FGA, FGG, FGB
response to metal ion (GO:0010038)	-	3.91	0.0	FGA, FGG, FGB
response to inorganic substance (GO:0010035)	-	3.56	0.001	FGA, FGG, FGB
platelet activation (GO:0030168)	-	4.96	0.0	FGA, FGG, FGB
regulation of phosphorylation (GO:0042325)	-	2.5	0.048	FGA, FGG, FGB
positive regulation of phosphorylation (GO:0042327)	-	2.9	0.014	FGA, FGG, FGB
vesicle-mediated transport (GO:0016192)	-	2.72	0.022	FGA, FGG, FGB
negative regulation of apoptotic signaling pathway (GO:2001234)	-	4.42	0.0	FGA, FGG, FGB
extracellular matrix organization (GO:0030198)	-	4.01	0.001	FGA, FGG, FGB
regulation of cell morphogenesis (GO:0022604)	-	3.4	0.002	FGA, FGG, FGB
regulation of anatomical structure morphogenesis (GO:0022603)	-	2.79	0.011	FGA, FGG, FGB
secretion by cell (GO:0032940)	-	3.59	0.002	FGA, FGG, FGB
positive regulation of protein transport (GO:0051222)	-	3.61	0.0	FGA, FGG, FGB
regulation of protein transport (GO:0051223)	-	3.12	0.002	FGA, FGG, FGB
regulation of protein secretion (GO:0050708)	-	3.77	0.0	FGA, FGG, FGB
exocytosis (GO:0006887)	-	4.11	0.023	FGA, FGG, FGB
macromolecular complex assembly (GO:0065003)	-	2.55	0.034	FGA, FGG, FGB
positive regulation of cell-substrate adhesion (GO:0010811)	-	5.11	0.0	FGA, FGG, FGB
regulation of MAPK cascade (GO:0043408)	-	3.22	0.004	FGA, FGG, FGB
positive regulation of cellular component organization (GO:0051130)	-	2.68	0.01	FGA, FGG, FGB
regulation of establishment of protein localization (GO:0070201)	-	3.02	0.003	FGA, FGG, FGB
single organism cell adhesion (GO:0098602)	-	3.63	0.001	FGA, FGG, FGB
positive regulation of vasoconstriction (GO:0045907)	-	6.12	0.0	FGA, FGG, FGB
cell activation (GO:0001775)	-	3.47	0.006	FGA, FGG, FGB
coagulation (GO:0050817)	-	4.51	0.003	FGA, FGG, FGB
positive regulation of intracellular signal transduction (GO:1902533)	-	2.95	0.01	FGA, FGG, FGB
positive regulation of MAPK cascade (GO:0043410)	-	3.57	0.001	FGA, FGG, FGB
secretion (GO:0046903)	-	3.38	0.004	FGA, FGG, FGB
positive regulation of protein secretion (GO:0050714)	-	4.39	0.005	FGA, FGG, FGB
positive regulation of multicellular organismal process (GO:0051240)	-	2.49	0.006	FGA, FGG, FGB
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902042)	-	6.2	0.0	FGA, FGG, FGB
regulation of extrinsic apoptotic signaling pathway via death domain receptors (GO:1902041)	-	5.72	0.0	FGA, FGG, FGB
regulation of cell adhesion (GO:0030155)	-	3.27	0.001	FGA, FGG, FGB
positive regulation of signaling (GO:0023056)	-	2.41	0.041	FGA, FGG, FGB
negative regulation of signaling (GO:0023057)	-	2.65	0.024	FGA, FGG, FGB
negative regulation of cell communication (GO:0010648)	-	2.66	0.024	FGA, FGG, FGB
positive regulation of cell communication (GO:0010647)	-	2.41	0.041	FGA, FGG, FGB
protein complex assembly (GO:0006461)	-	2.78	0.02	FGA, FGG, FGB
regulation of protein localization (GO:0032880)	-	2.88	0.004	FGA, FGG, FGB
regulation of system process (GO:0044057)	-	3.53	0.002	FGA, FGG, FGB
positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)	-	6.4	0.0	FGA, FGG, FGB
regulation of substrate adhesion-dependent cell spreading (GO:1900024)	-	5.99	0.0	FGA, FGG, FGB
regulation of cell development (GO:0060284)	-	3.01	0.008	FGA, FGG, FGB
regulation of cell morphogenesis involved in differentiation (GO:0010769)	-	3.91	0.0	FGA, FGG, FGB
biological adhesion (GO:0022610)	-	2.81	0.02	FGA, FGG, FGB
regulation of exocytosis (GO:0017157)	-	4.59	0.0	FGA, FGG, FGB
regulation of body fluid levels (GO:0050878)	-	3.76	0.006	FGA, FGG, FGB
regulation of endothelial cell apoptotic process (GO:2000351)	-	5.99	0.0	FGA, FGG, FGB
negative regulation of endothelial cell apoptotic process (GO:2000352)	-	6.43	0.0	FGA, FGG, FGB
regulation of vesicle-mediated transport (GO:0060627)	-	3.63	0.001	FGA, FGG, FGB
positive regulation of cell differentiation (GO:0045597)	-	3.01	0.007	FGA, FGG, FGB
regulation of hormone secretion (GO:0046883)	-	4.18	0.024	FGA, FGG, FGB
positive regulation of hormone secretion (GO:0046887)	-	4.98	0.0	FGA, FGG, FGB
protein polymerization (GO:0051258)	-	5.8	0.0	FGA, FGG, FGB
positive regulation of developmental process (GO:0051094)	-	2.77	0.017	FGA, FGG, FGB
positive regulation of cell morphogenesis involved in differentiation (GO:0010770)	-	4.65	0.0	FGA, FGG, FGB
positive regulation of ERK1 and ERK2 cascade (GO:0070374)	-	4.56	0.0	FGA, FGG, FGB
regulation of ERK1 and ERK2 cascade (GO:0070372)	-	4.23	0.007	FGA, FGG, FGB
positive regulation of exocytosis (GO:0045921)	-	5.41	0.0	FGA, FGG, FGB
single organismal cell-cell adhesion (GO:0016337)	-	3.69	0.001	FGA, FGG, FGB
regulation of cellular localization (GO:0060341)	NEW	3.03	0.023	FGA, FGG, FGB
regulation of cell-cell adhesion (GO:0022407)	-	3.79	0.0	FGA, FGG, FGB
cellular macromolecular complex assembly (GO:0034622)	-	3.18	0.004	FGA, FGG, FGB
positive regulation of cell-cell adhesion (GO:0022409)	-	4.23	0.0	FGA, FGG, FGB
platelet degranulation (GO:0002576)	-	5.12	0.0	FGA, FGG, FGB
negative regulation of apoptotic process (GO:0043066)	-	3.04	0.009	FGA, FGG, FGB
extracellular structure organization (GO:0043062)	-	4.0	0.001	FGA, FGG, FGB
negative regulation of programmed cell death (GO:0043069)	-	3.02	0.01	FGA, FGG, FGB
positive regulation of phosphate metabolic process (GO:0045937)	-	2.78	0.019	FGA, FGG, FGB
regulation of cell-substrate adhesion (GO:0010810)	-	4.56	0.0	FGA, FGG, FGB
homotypic cell-cell adhesion (GO:0034109)	-	5.76	0.0	FGA, FGG, FGB
positive regulation of phosphorus metabolic process (GO:0010562)	-	2.78	0.019	FGA, FGG, FGB
cell adhesion (GO:0007155)	-	2.82	0.02	FGA, FGG, FGB
cellular protein complex assembly (GO:0043623)	-	3.9	0.028	FGA, FGG, FGB
regulation of peptide secretion (GO:0002791)	-	4.38	0.015	FGA, FGG, FGB
positive regulation of peptide secretion (GO:0002793)	-	5.22	0.001	FGA, FGG, FGB
platelet aggregation (GO:0070527)	-	6.04	0.0	FGA, FGG, FGB

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
external side of plasma membrane (GO:0009897)	4.46	3	FGA, FGG, FGB
cytoplasmic membrane-bounded vesicle lumen (GO:0060205)	5.19	3	FGA, FGG, FGB
membrane-enclosed lumen (GO:0031974)	3.05	3	FGA, FGG, FGB
intracellular organelle (GO:0043229)	0.51	3	FGA, FGG, FGB
side of membrane (GO:0098552)	4.22	3	FGA, FGG, FGB
membrane-bounded organelle (GO:0043227)	0.47	3	FGA, FGG, FGB
organelle (GO:0043226)	0.4	3	FGA, FGG, FGB
cytoplasm (GO:0005737)	1.01	3	FGA, FGG, FGB
platelet alpha granule (GO:0031091)	7.09	3	FGA, FGG, FGB
vesicle (GO:0031982)	1.64	3	FGA, FGG, FGB
platelet alpha granule lumen (GO:0031093)	5.81	3	FGA, FGG, FGB
cytoplasmic, membrane-bounded vesicle (GO:0016023)	3.12	3	FGA, FGG, FGB
cytoplasmic vesicle (GO:0031410)	2.87	3	FGA, FGG, FGB
membrane (GO:0016020)	0.68	3	FGA, FGG, FGB
fibrinogen complex (GO:0005577)	7.61	3	FGA, FGG, FGB
blood microparticle (GO:0072562)	4.88	3	FGA, FGG, FGB
membrane-bounded vesicle (GO:0031988)	1.71	3	FGA, FGG, FGB
cytoplasmic vesicle part (GO:0044433)	3.41	3	FGA, FGG, FGB
plasma membrane (GO:0005886)	1.39	3	FGA, FGG, FGB
plasma membrane part (GO:0044459)	1.95	3	FGA, FGG, FGB
macromolecular complex (GO:0032991)	1.35	3	FGA, FGG, FGB
secretory vesicle (GO:0099503)	4.0	3	FGA, FGG, FGB
secretory granule (GO:0030141)	4.34	3	FGA, FGG, FGB
cell surface (GO:0009986)	3.44	3	FGA, FGG, FGB
cytoplasmic region (GO:0099568)	4.51	3	FGA, FGG, FGB
cell cortex (GO:0005938)	4.78	3	FGA, FGG, FGB
secretory granule lumen (GO:0034774)	5.38	3	FGA, FGG, FGB
vesicle lumen (GO:0031983)	5.17	3	FGA, FGG, FGB
extracellular vesicle (GO:1903561)	1.89	3	FGA, FGG, FGB
extracellular space (GO:0005615)	2.63	3	FGA, FGG, FGB
protein complex (GO:0043234)	1.51	3	FGA, FGG, FGB
extracellular organelle (GO:0043230)	1.89	3	FGA, FGG, FGB
intracellular membrane-bounded organelle (GO:0043231)	0.6	3	FGA, FGG, FGB
organelle lumen (GO:0043233)	3.05	3	FGA, FGG, FGB
extracellular exosome (GO:0070062)	1.89	3	FGA, FGG, FGB
cell part (GO:0044464)	0.11	3	FGA, FGG, FGB
intracellular organelle part (GO:0044446)	0.81	3	FGA, FGG, FGB
intracellular organelle lumen (GO:0070013)	3.05	3	FGA, FGG, FGB
cytoplasmic part (GO:0044444)	0.82	3	FGA, FGG, FGB
extracellular region (GO:0005576)	2.18	3	FGA, FGG, FGB
intracellular part (GO:0044424)	0.28	3	FGA, FGG, FGB
membrane part (GO:0044425)	0.95	3	FGA, FGG, FGB
extracellular region part (GO:0044421)	1.57	3	FGA, FGG, FGB
organelle part (GO:0044422)	0.79	3	FGA, FGG, FGB
intracellular vesicle (GO:0097708)	2.86	3	FGA, FGG, FGB

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
external side of plasma membrane (GO:0009897)	-	4.46	0.0	FGA, FGG, FGB
platelet alpha granule (GO:0031091)	-	7.09	0.0	FGA, FGG, FGB
extracellular space (GO:0005615)	-	2.63	0.009	FGA, FGG, FGB
platelet alpha granule lumen (GO:0031093)	-	5.81	0.0	FGA, FGG, FGB
organelle lumen (GO:0043233)	-	3.05	0.002	FGA, FGG, FGB
cytoplasmic membrane-bounded vesicle (GO:0016023)	-	3.12	0.001	FGA, FGG, FGB
secretory granule (GO:0030141)	-	4.34	0.0	FGA, FGG, FGB
cell surface (GO:0009986)	-	3.44	0.041	FGA, FGG, FGB
secretory granule lumen (GO:0034774)	-	5.38	0.0	FGA, FGG, FGB
cytoplasmic vesicle (GO:0031410)	-	2.87	0.002	FGA, FGG, FGB
membrane-enclosed lumen (GO:0031974)	-	3.05	0.002	FGA, FGG, FGB
cytoplasmic membrane-bounded vesicle lumen (GO:0060205)	-	5.19	0.0	FGA, FGG, FGB
fibrinogen complex (GO:0005577)	-	7.61	0.0	FGA, FGG, FGB
extracellular region (GO:0005576)	-	2.18	0.024	FGA, FGG, FGB
cell cortex (GO:0005938)	-	4.78	0.0	FGA, FGG, FGB
side of membrane (GO:0098552)	-	4.22	0.006	FGA, FGG, FGB
vesicle lumen (GO:0031983)	-	5.17	0.0	FGA, FGG, FGB
cytoplasmic vesicle part (GO:0044433)	-	3.41	0.001	FGA, FGG, FGB
blood microparticle (GO:0072562)	-	4.88	0.0	FGA, FGG, FGB