Gene table of ATR : ATR serine/threonine kinase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with ATR	OMIM link	Number of associated genes	genes
614564	CUTANEOUS TELANGIECTASIA AND CANCER SYNDROME, FAMILIAL	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	ATR
PS210600	SECKEL SYNDROME	ClinVar, OMIM	link to OMIM	8	NIN, CEP63, DNA2, TRAIP, RBBP8, CEP152, ATR, CENPJ

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Regulation of the Fanconi anemia pathway	R-HSA-419552	9.66
G2/M Checkpoints	R-HSA-69481	6.46
DNA Repair	R-HSA-73894	5.8
Meiosis	R-HSA-1500620	6.59
G2/M DNA damage checkpoint	R-HSA-69473	7.15
Cellular responses to stress	R-HSA-2262752	4.56
Cell Cycle Checkpoints	R-HSA-69620	5.64
Cellular response to heat stress	R-HSA-3371556	6.59
Meiotic synapsis	R-HSA-1221632	7.18
Cell Cycle	R-HSA-1640170	3.89
Regulation of HSF1-mediated heat shock response	R-HSA-3371453	6.94
Activation of ATR in response to replication stress	R-HSA-176187	7.77
Fanconi Anemia pathway	R-HSA-419524	8.4

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
nucleotide binding	GO:0000166	1.96
protein serine/threonine kinase activity	GO:0004674	3.64
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
MutSalpha complex binding	GO:0032407	8.13
MutLalpha complex binding	GO:0032405	7.95
mismatch repair complex binding	GO:0032404	7.66
kinase activity	GO:0016301	2.93
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
adenyl ribonucleotide binding	GO:0032559	2.41
ATP binding	GO:0005524	2.43
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19