Gene table of DNA2 : DNA replication helicase/nuclease 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with DNA2	OMIM link	Number of associated genes	genes
PS157640	PROGRESSIVE EXTERNAL OPHTHALMOPLEGIA WITH MTDNA DELETIONS	ClinVar, OMIM, HUMSAVAR	link to OMIM	7	SLC25A4, DNA2, C10orf2, RRM2B, RNASEH1, POLG, POLG2
PS210600	SECKEL SYNDROME	OMIM	link to OMIM	8	NIN, CEP63, DNA2, TRAIP, RBBP8, CEP152, ATR, CENPJ

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Annotation of the gene DNA2

Associated genes in ENSEMBL

ENSG00000138346

Associated proteins - SwissProt Accession ID

P51530

Associated PDB IDs

5eay

Cytogenetic Band

10q21.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
DNA replication	hsa03030	7.48

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
S Phase	R-HSA-69242	6.02
Telomere Maintenance	R-HSA-157579	7.1
Processive synthesis on the C-strand of the telomere	R-HSA-174414	9.4
Telomere C-strand (Lagging Strand) Synthesis	R-HSA-174417	8.46
Extension of Telomeres	R-HSA-180786	8.12
Removal of the Flap Intermediate from the C-strand	R-HSA-174437	9.66
DNA Replication	R-HSA-69306	6.25
DNA strand elongation	R-HSA-69190	7.94
Cell Cycle, Mitotic	R-HSA-69278	4.16
Synthesis of DNA	R-HSA-69239	6.37
Removal of the Flap Intermediate	R-HSA-69166	9.18
Cell Cycle	R-HSA-1640170	3.89
Chromosome Maintenance	R-HSA-73886	6.56
Lagging Strand Synthesis	R-HSA-69186	8.59
Processive synthesis on the lagging strand	R-HSA-69183	8.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
ATPase activity	GO:0016887	3.65
purine ribonucleoside triphosphate binding	GO:0035639	2.22
5'-flap endonuclease activity	GO:0017108	8.13
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
DNA helicase activity	GO:0003678	5.73
endodeoxyribonuclease activity, producing 5'-phosphomonoesters	GO:0016888	7.25
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
metal cluster binding	GO:0051540	5.55
pyrophosphatase activity	GO:0016462	3.04
endodeoxyribonuclease activity	GO:0004520	5.81
ion binding	GO:0043167	1.36
single-stranded DNA-dependent ATPase activity	GO:0043142	7.17
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
deoxyribonuclease activity	GO:0004536	5.48
ATP binding	GO:0005524	2.43
hydrolase activity	GO:0016787	1.9
nucleoside-triphosphatase activity	GO:0017111	3.09
hydrolase activity, acting on ester bonds	GO:0016788	3.1
helicase activity	GO:0004386	4.69
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
site-specific endodeoxyribonuclease activity, specific for altered base	GO:0016890	9.05
flap endonuclease activity	GO:0048256	7.79
4 iron, 4 sulfur cluster binding	GO:0051539	6.0
DNA-dependent ATPase activity	GO:0008094	5.31
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
ATPase activity, coupled	GO:0042623	3.97
endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	GO:0016893	5.83
nuclease activity	GO:0004518	4.33
endonuclease activity	GO:0004519	4.78
iron-sulfur cluster binding	GO:0051536	5.55
adenyl nucleotide binding	GO:0030554	2.4
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
carbohydrate derivative binding	GO:0097367	2.03
adenyl ribonucleotide binding	GO:0032559	2.41
protein binding	GO:0005515	0.46
organic cyclic compound binding	GO:0097159	1.05
purine ribonucleotide binding	GO:0032555	2.2
5'-3' DNA helicase activity	GO:0043139	7.66
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19