Disease table of SECKEL SYNDROME OMIM ID: PS210600

Gene-disease associations table

Gene	Associated with SECKEL SYNDROME in	Link to HGNC	Cytogenetic band	Number of associated diseases	Associated diseases
CEP152	ClinVar, OMIM, HUMSAVAR	HGNC link	15q21.1	2	PS251200, PS210600
DNA2	OMIM	HGNC link	10q21.3	2	PS157640, PS210600
NIN	ClinVar, OMIM, HUMSAVAR	HGNC link	14q22.1	1	PS210600
CENPJ	ClinVar, OMIM	HGNC link	13q12.13	2	PS251200, PS210600
CEP63	ClinVar, OMIM	HGNC link	3q22.2	1	PS210600
TRAIP	ClinVar, OMIM	HGNC link	3p21.31	1	PS210600
RBBP8	ClinVar, OMIM, HUMSAVAR	HGNC link	18q11.2	3	251255, 260350, PS210600
ATR	ClinVar, OMIM	HGNC link	3q23	2	614564, PS210600

Download the disease annotation in CSV format

Relations among genes:

Tandem repeat annotations from DGD

Cytogenetic band analysis

By region

Shared region	Number of genes associated with the disease	Genes associated with the disease
3q2	2	CEP63, ATR

By arm

Shared arm	Number of genes associated with the disease	Genes associated with the disease
3q	2	CEP63, ATR

By chromosome

Shared chromosome	Number of genes associated with the disease	Genes associated with the disease
3	3	CEP63, ATR, TRAIP

Transcription Factors (TF) annotation from TRRUST

regulated gene	associated to this disease	# TFs	TFs	# TFs associated with this disease	TFs associated with this disease
RBBP8	YES	1	YBX1	0

Interactions from BIOGRID - physical

Gene1	Gene2	Direct Interaction	Number of shared interactors	Shared genes in interaction
CEP152	NIN	No	40	TXLNA, WDR83, TTC28, HAUS8, TTF2, GPATCH1, TJP1, TTK, HAUS3, CNTRL, CC2D1A, PALLD, CEP128, YWHAH, TCHP, SAMD4B, KIAA1244, LUZP1, OFD1, PCM1, TNRC6B, NEDD1, CEP63, CCDC138, SDCCAG3, CEP192, CEP350, FGFR1OP, KIAA1671, ERC1, DBT, KIF14, POC5, HAUS6, MED4, TP53BP2, TP53, CEP131, RASSF8, ECH1
CEP152	CENPJ	Yes	35	CEP85, SMG7, HAUS8, ALMS1, HAUS3, ATXN10, TCHP, PALLD, CEP120, YWHAH, OFD1, TNRC6B, GPX1, NEDD1, FAM21A, PCNT, CCDC138, SDCCAG3, CEP192, CNOT1, TNIP1, ADSL, KIAA1671, SASS6, PCM1, GPATCH1, KIF14, HAUS6, TNRC6A, TP53BP2, XRN1, KIAA0753, CEP131, CNOT10, TTK
CEP152	CEP63	Yes	29	TXLNA, NDEL1, HAUS8, FGFR1OP, ALMS1, HAUS3, RGPD3, TCHP, CEP128, PLK4, OFD1, TNRC6B, CCDC67, TBK1, CEP152, PCNT, CCDC138, LUZP1, CEP192, CEP350, CEP85, KIAA1671, PCM1, KIF14, HAUS6, MED4, KIAA0753, CEP131, TTK
CEP152	TRAIP	No	1	TBK1
CEP152	ATR	No	1	TP53
DNA2	NIN	No	1	UPF1
DNA2	CENPJ	No	2	NXF1, MOV10
DNA2	RBBP8	Yes	1	RBBP8
DNA2	ATR	No	5	RPA3, EP300, UPF1, RPA1, RPA2
NIN	CENPJ	No	31	CSPP1, LATS2, HAUS7, HAUS8, GPATCH1, CLASP1, HAUS3, TCHP, PALLD, YWHAH, HAUS1, OFD1, TNRC6B, SSX2IP, UNC45A, NEDD1, CEP170, CCDC138, SDCCAG3, CLASP2, AP3D1, CKAP2, KIAA1671, PCM1, KIF14, HAUS6, TP53BP2, PLK1, CEP131, CEP192, TTK
NIN	CEP63	Yes	29	TXLNA, NCKAP5L, SSX2IP, HAUS4, FGFR1OP, HAUS3, HAUS1, CSPP1, TCHP, CEP128, TTK, HAUS7, OFD1, TNRC6B, HAUS8, CCDC138, LUZP1, CEP192, CEP350, KIAA1671, PCM1, KIF14, NME7, HAUS6, MED4, PIBF1, HAUS5, CEP131, NIN
NIN	RBBP8	No	1	PLK1
NIN	ATR	No	4	CCNB2, TP53, UPF1, CEP164
CENPJ	CEP63	No	31	SPICE1, HAUS7, SSX2IP, CSPP1, ALMS1, HAUS3, CEP131, KIF7, TCHP, MPHOSPH9, TTK, HAUS1, OFD1, TNRC6B, CCDC85C, CEP55, HAUS8, LZTS2, CEP152, PCNT, CCDC138, CEP192, CEP85, KIAA1671, PCM1, KIF14, HAUS6, LRRC49, WRAP73, KIAA0753, C2CD3
CENPJ	TRAIP	No	1	MAPRE2
CENPJ	RBBP8	No	2	KIF7, PLK1
CENPJ	ATR	No	1	AP3B1
CEP63	TRAIP	No	1	TBK1
CEP63	RBBP8	No	1	KIF7
TRAIP	RBBP8	No	1	PCNA
RBBP8	ATR	No	6	ATM, NBN, MRE11A, BRCA1, IKBKG, FANCD2

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from BIOGRID - genetic

Interactions from STRING

Gene1	Gene2	Direct Interaction	Interaction mode	Number of shared interactors	Shared genes in interaction
CEP152	CENPJ	Yes	binding	64	TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP76, CEP70, ALMS1, CSNK1D, PLK1, CEP135, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, HAUS2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP63, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, TUBGCP3, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, CEP290, DCTN2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1, TUBG1
CEP152	CEP63	Yes	binding	64	TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP70, ALMS1, CSNK1D, PLK1, CEP135, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, HAUS2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP76, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, CENPJ, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, TUBGCP3, CEP290, DCTN2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1, TUBG1
CEP152	ATR	No	-	2	CDK1, CEP164
DNA2	CEP63	No	-	0
DNA2	TRAIP	No	-	1	UBC
DNA2	RBBP8	No	-	4	ATR, EXO1, PCNA, FANCD2
DNA2	ATR	Yes	activation, binding	11	FANCD2, RPA2, WRN, OBFC1, BLM, RPA1, RPA4, PCNA, UBC, RPA3, RECQL
CENPJ	CEP63	Yes	binding	64	TUBGCP5, CDK1, CDK5RAP2, CEP57, CSNK1E, SSNA1, ACTR1A, YWHAE, CEP76, CEP70, ALMS1, CSNK1D, PLK1, CEP135, MAPRE1, TUBA4A, TUBGCP6, PRKACA, ODF2, HSP90AA1, CEP192, SFI1, HAUS2, CEP250, DYNLL1, OFD1, CNTRL, DYNC1H1, TUBA1A, DYNC1I2, PCM1, PCNT, TUBGCP2, AZI1, CEP164, NEDD1, CEP152, CCP110, DCTN3, CKAP5, SDCCAG8, PRKAR2B, TUBB4B, CEP78, TUBGCP3, NINL, PAFAH1B1, FGFR1OP, PPP2R1A, BORA, CEP290, DCTN2, AJUBA, AURKA, CLASP1, NEK2, TUBGCP4, CEP72, YWHAG, TUBG2, TUBB4A, PLK4, NDE1, TUBG1
CENPJ	RBBP8	No	-	1	BRCA1
CENPJ	ATR	No	-	4	BRCA1, YWHAZ, CEP164, CDK1
CEP63	RBBP8	No	-	0
CEP63	ATR	No	-	2	CDK1, CEP164
TRAIP	ATR	No	-	1	UBC
RBBP8	ATR	Yes	activation, binding	10	TOPBP1, TREX1, CDK2, CHEK1, FANCD2, BARD1, TP53BP1, PCNA, H2AFX, BRCA1

Direct interactions graph
Interactions graph (direct and indirect interactions, when direct are not available)

Interactions from CORUM

Interactions from CENSUS

Interactions from PDB

Interactions from manually curated literature

KEGG pathways annotation: NET-GE enrichment (no shared terms)

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Replication and repair	NEW	5.41	0.007	ATR, RBBP8, DNA2

REACTOME pathways annotation: shared terms / NET-GE enrichment

Shared terms

REACTOME term	REACTOME term ID	IC	Number of genes with the same term	Genes
Cell Cycle	R-HSA-1640170	3.89	6	CEP152, CEP63, ATR, CENPJ, RBBP8, DNA2
Cell Cycle, Mitotic	R-HSA-69278	4.16	4	CENPJ, CEP63, CEP152, DNA2
Recruitment of mitotic centrosome proteins and complexes	R-HSA-380270	6.68	3	CENPJ, CEP63, CEP152
Regulation of PLK1 Activity at G2/M Transition	R-HSA-2565942	6.66	3	CENPJ, CEP63, CEP152
Loss of proteins required for interphase microtubule organization from the centrosome	R-HSA-380284	7.03	3	CENPJ, CEP63, CEP152
Centrosome maturation	R-HSA-380287	6.68	3	CENPJ, CEP63, CEP152
Mitotic G2-G2/M phases	R-HSA-453274	6.04	3	CENPJ, CEP63, CEP152
Anchoring of the basal body to the plasma membrane	R-HSA-5620912	6.51	3	CENPJ, CEP63, CEP152
Loss of Nlp from mitotic centrosomes	R-HSA-380259	7.03	3	CENPJ, CEP63, CEP152
Assembly of the primary cilium	R-HSA-5617833	5.44	3	CENPJ, CEP63, CEP152
Organelle biogenesis and maintenance	R-HSA-1852241	4.63	3	CENPJ, CEP63, CEP152
G2/M Transition	R-HSA-69275	6.06	3	CENPJ, CEP63, CEP152
Meiosis	R-HSA-1500620	6.59	2	ATR, RBBP8

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
Recruitment of mitotic centrosome proteins and complexes (R-HSA-380270)	-	6.68	0.001	CENPJ, CEP63, CEP152
Regulation of PLK1 Activity at G2/M Transition (R-HSA-2565942)	-	6.66	0.001	CENPJ, CEP63, CEP152
Loss of proteins required for interphase microtubule organization from the centrosome (R-HSA-380284)	-	7.03	0.0	CENPJ, CEP63, CEP152
Organelle biogenesis and maintenance (R-HSA-1852241)	-	4.63	0.047	CENPJ, CEP63, CEP152, ATR
Mitotic G2-G2/M phases (R-HSA-453274)	-	6.04	0.006	CENPJ, CEP63, CEP152
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)	-	6.51	0.001	CENPJ, CEP63, CEP152
Cell Cycle, Mitotic (R-HSA-69278)	-	4.16	0.001	CENPJ, CEP63, CEP152, DNA2, ATR
Loss of Nlp from mitotic centrosomes (R-HSA-380259)	-	7.03	0.0	CENPJ, CEP63, CEP152
Cell Cycle (R-HSA-1640170)	-	3.89	0.0	CEP152, CEP63, ATR, CENPJ, RBBP8, DNA2
Assembly of the primary cilium (R-HSA-5617833)	-	5.44	0.009	CENPJ, CEP63, CEP152
Centrosome maturation (R-HSA-380287)	-	6.68	0.001	CENPJ, CEP63, CEP152
G2/M Transition (R-HSA-69275)	-	6.06	0.002	CENPJ, CEP63, CEP152

GO - molecular function annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
binding (GO:0005488)	0.18	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
protein binding (GO:0005515)	0.46	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
catalytic activity (GO:0003824)	1.05	4	TRAIP, DNA2, RBBP8, ATR
heterocyclic compound binding (GO:1901363)	1.06	4	NIN, RBBP8, ATR, DNA2
organic cyclic compound binding (GO:0097159)	1.05	4	NIN, RBBP8, ATR, DNA2
cation binding (GO:0043169)	1.4	3	TRAIP, DNA2, NIN
ion binding (GO:0043167)	1.36	3	TRAIP, DNA2, NIN
carbohydrate derivative binding (GO:0097367)	2.03	3	NIN, DNA2, ATR
ribonucleoside binding (GO:0032549)	2.22	3	NIN, DNA2, ATR
purine nucleoside binding (GO:0001883)	2.22	3	NIN, DNA2, ATR
nucleotide binding (GO:0000166)	1.96	3	NIN, DNA2, ATR
small molecule binding (GO:0036094)	1.89	3	NIN, DNA2, ATR
purine ribonucleoside triphosphate binding (GO:0035639)	2.22	3	ATR, DNA2, NIN
ribonucleotide binding (GO:0032553)	2.19	3	NIN, DNA2, ATR
nucleic acid binding (GO:0003676)	1.44	3	ATR, RBBP8, DNA2
DNA binding (GO:0003677)	1.92	3	DNA2, RBBP8, ATR
purine ribonucleotide binding (GO:0032555)	2.2	3	NIN, DNA2, ATR
purine nucleotide binding (GO:0017076)	2.19	3	ATR, DNA2, NIN
metal ion binding (GO:0046872)	1.41	3	TRAIP, DNA2, NIN
purine ribonucleoside binding (GO:0032550)	2.22	3	NIN, DNA2, ATR
nucleoside phosphate binding (GO:1901265)	1.96	3	ATR, DNA2, NIN
nucleoside binding (GO:0001882)	2.21	3	NIN, DNA2, ATR
hydrolase activity (GO:0016787)	1.9	2	DNA2, RBBP8
adenyl nucleotide binding (GO:0030554)	2.4	2	DNA2, ATR
nuclease activity (GO:0004518)	4.33	2	DNA2, RBBP8
endonuclease activity (GO:0004519)	4.78	2	DNA2, RBBP8
endodeoxyribonuclease activity (GO:0004520)	5.81	2	DNA2, RBBP8
hydrolase activity, acting on ester bonds (GO:0016788)	3.1	2	DNA2, RBBP8
protein kinase binding (GO:0019901)	3.44	2	CENPJ, CEP152
kinase binding (GO:0019900)	3.32	2	CENPJ, CEP152
transferase activity (GO:0016740)	1.95	2	TRAIP, ATR
adenyl ribonucleotide binding (GO:0032559)	2.41	2	DNA2, ATR
enzyme binding (GO:0019899)	2.27	2	CENPJ, CEP152
deoxyribonuclease activity (GO:0004536)	5.48	2	DNA2, RBBP8
ATP binding (GO:0005524)	2.43	2	DNA2, ATR

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
deoxyribonuclease activity (GO:0004536)	-	5.48	0.026	DNA2, RBBP8
endodeoxyribonuclease activity (GO:0004520)	-	5.81	0.015	DNA2, RBBP8

GO - biological process annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
cellular process (GO:0009987)	0.26	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
single-organism cellular process (GO:0044763)	0.65	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
single-organism process (GO:0044699)	0.48	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
organelle organization (GO:0006996)	2.02	6	CEP152, NIN, CEP63, CENPJ, RBBP8, DNA2
cellular component organization (GO:0016043)	1.24	6	CEP152, NIN, CEP63, CENPJ, RBBP8, DNA2
regulation of cellular process (GO:0050794)	0.5	6	CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
cell cycle process (GO:0022402)	2.75	6	CEP152, CEP63, ATR, CENPJ, RBBP8, DNA2
biological regulation (GO:0065007)	0.39	6	CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
regulation of biological process (GO:0050789)	0.45	6	CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
cellular component organization or biogenesis (GO:0071840)	1.22	6	CEP152, NIN, CEP63, CENPJ, RBBP8, DNA2
cellular response to stimulus (GO:0051716)	1.97	5	CENPJ, CEP63, RBBP8, DNA2, ATR
response to stimulus (GO:0050896)	1.22	5	CENPJ, CEP63, RBBP8, DNA2, ATR
response to stress (GO:0006950)	1.8	5	CENPJ, CEP63, RBBP8, ATR, DNA2
mitotic cell cycle process (GO:1903047)	3.12	5	CENPJ, CEP63, RBBP8, CEP152, DNA2
cellular response to DNA damage stimulus (GO:0006974)	3.17	5	CENPJ, CEP63, RBBP8, DNA2, ATR
single-organism organelle organization (GO:1902589)	2.68	5	CENPJ, CEP63, CEP152, DNA2, NIN
cellular response to stress (GO:0033554)	2.51	5	CENPJ, CEP63, RBBP8, ATR, DNA2
primary metabolic process (GO:0044238)	0.69	4	TRAIP, DNA2, RBBP8, ATR
microtubule-based process (GO:0007017)	3.54	4	CENPJ, CEP63, CEP152, NIN
cellular macromolecule metabolic process (GO:0044260)	0.93	4	TRAIP, DNA2, RBBP8, ATR
cell cycle checkpoint (GO:0000075)	4.79	4	CEP63, RBBP8, DNA2, ATR
regulation of signal transduction (GO:0009966)	1.84	4	TRAIP, ATR, RBBP8, DNA2
regulation of response to stimulus (GO:0048583)	1.54	4	TRAIP, DNA2, RBBP8, ATR
cellular metabolic process (GO:0044237)	0.69	4	TRAIP, DNA2, RBBP8, ATR
macromolecule metabolic process (GO:0043170)	0.83	4	TRAIP, ATR, RBBP8, DNA2
cell cycle phase transition (GO:0044770)	4.24	4	CENPJ, CEP63, RBBP8, CEP152
organic substance metabolic process (GO:0071704)	0.63	4	TRAIP, ATR, RBBP8, DNA2
mitotic cell cycle phase transition (GO:0044772)	4.27	4	CENPJ, CEP63, RBBP8, CEP152
metabolic process (GO:0008152)	0.58	4	TRAIP, DNA2, RBBP8, ATR
regulation of signaling (GO:0023051)	1.72	4	TRAIP, DNA2, RBBP8, ATR
negative regulation of biological process (GO:0048519)	1.33	4	CENPJ, TRAIP, ATR, RBBP8
regulation of cell communication (GO:0010646)	1.73	4	TRAIP, ATR, RBBP8, DNA2
negative regulation of cellular process (GO:0048523)	1.41	4	CENPJ, TRAIP, ATR, RBBP8
DNA integrity checkpoint (GO:0031570)	5.25	4	CEP63, RBBP8, ATR, DNA2
cellular component assembly (GO:0022607)	2.14	3	CENPJ, CEP63, CEP152
regulation of primary metabolic process (GO:0080090)	1.08	3	DNA2, RBBP8, ATR
regulation of metabolic process (GO:0019222)	1.02	3	DNA2, RBBP8, ATR
G2/M transition of mitotic cell cycle (GO:0000086)	4.84	3	CENPJ, CEP63, CEP152
regulation of cellular biosynthetic process (GO:0031326)	1.38	3	DNA2, RBBP8, ATR
regulation of cellular metabolic process (GO:0031323)	1.07	3	DNA2, RBBP8, ATR
nucleic acid metabolic process (GO:0090304)	1.46	3	DNA2, RBBP8, ATR
cellular biosynthetic process (GO:0044249)	1.37	3	ATR, RBBP8, DNA2
cellular nitrogen compound metabolic process (GO:0034641)	1.22	3	DNA2, RBBP8, ATR
nitrogen compound metabolic process (GO:0006807)	1.13	3	ATR, RBBP8, DNA2
microtubule cytoskeleton organization (GO:0000226)	4.13	3	CENPJ, CEP63, NIN
signal transduction (GO:0007165)	1.28	3	CENPJ, TRAIP, CEP63
cellular macromolecule biosynthetic process (GO:0034645)	1.66	3	DNA2, RBBP8, ATR
centriole assembly (GO:0098534)	6.78	3	CENPJ, CEP63, CEP152
organic substance biosynthetic process (GO:1901576)	1.34	3	DNA2, RBBP8, ATR
intracellular signal transduction (GO:0035556)	2.39	3	CENPJ, TRAIP, CEP63
cell cycle (GO:0007049)	3.14	3	CEP63, RBBP8, ATR
nucleobase-containing compound metabolic process (GO:0006139)	1.35	3	ATR, RBBP8, DNA2
organelle assembly (GO:0070925)	3.75	3	CENPJ, CEP63, CEP152
cell cycle G2/M phase transition (GO:0044839)	4.82	3	CENPJ, CEP63, CEP152
regulation of cellular macromolecule biosynthetic process (GO:2000112)	1.46	3	ATR, RBBP8, DNA2
regulation of macromolecule metabolic process (GO:0060255)	1.08	3	DNA2, RBBP8, ATR
DNA replication (GO:0006260)	4.51	3	ATR, RBBP8, DNA2
organic cyclic compound metabolic process (GO:1901360)	1.26	3	DNA2, RBBP8, ATR
positive regulation of biological process (GO:0048518)	1.2	3	CENPJ, DNA2, ATR
regulation of signal transduction by p53 class mediator (GO:1901796)	4.63	3	DNA2, RBBP8, ATR
microtubule organizing center organization (GO:0031023)	5.26	3	CENPJ, CEP63, CEP152
DNA repair (GO:0006281)	3.59	3	ATR, RBBP8, DNA2
regulation of nucleobase-containing compound metabolic process (GO:0019219)	1.43	3	ATR, RBBP8, DNA2
cellular aromatic compound metabolic process (GO:0006725)	1.3	3	DNA2, RBBP8, ATR
centrosome organization (GO:0051297)	5.38	3	CENPJ, CEP63, CEP152
regulation of biosynthetic process (GO:0009889)	1.37	3	DNA2, RBBP8, ATR
biosynthetic process (GO:0009058)	1.32	3	ATR, RBBP8, DNA2
macromolecule biosynthetic process (GO:0009059)	1.61	3	DNA2, RBBP8, ATR
regulation of nitrogen compound metabolic process (GO:0051171)	1.36	3	ATR, RBBP8, DNA2
cytoskeleton organization (GO:0007010)	3.22	3	CENPJ, CEP63, NIN
regulation of intracellular signal transduction (GO:1902531)	2.31	3	DNA2, RBBP8, ATR
heterocycle metabolic process (GO:0046483)	1.31	3	ATR, RBBP8, DNA2
DNA damage checkpoint (GO:0000077)	5.37	3	CEP63, RBBP8, ATR
cell division (GO:0051301)	3.68	3	CENPJ, CEP63, RBBP8
regulation of macromolecule biosynthetic process (GO:0010556)	1.43	3	ATR, RBBP8, DNA2
centriole replication (GO:0007099)	6.96	3	CENPJ, CEP63, CEP152
DNA metabolic process (GO:0006259)	3.09	3	DNA2, RBBP8, ATR
positive regulation of cellular process (GO:0048522)	1.3	3	CENPJ, DNA2, ATR
negative regulation of metabolic process (GO:0009892)	1.93	2	ATR, RBBP8
positive regulation of metabolic process (GO:0009893)	1.74	2	DNA2, ATR
negative regulation of biosynthetic process (GO:0009890)	2.47	2	ATR, RBBP8
positive regulation of biosynthetic process (GO:0009891)	2.29	2	DNA2, ATR
negative regulation of cellular biosynthetic process (GO:0031327)	2.49	2	ATR, RBBP8
positive regulation of cellular metabolic process (GO:0031325)	1.81	2	DNA2, ATR
negative regulation of cellular metabolic process (GO:0031324)	2.01	2	ATR, RBBP8
regulation of cellular component organization (GO:0051128)	2.01	2	CENPJ, ATR
nucleic acid phosphodiester bond hydrolysis (GO:0090305)	4.12	2	DNA2, RBBP8
multicellular organismal process (GO:0032501)	1.45	2	ATR, RBBP8
positive regulation of cellular biosynthetic process (GO:0031328)	2.3	2	DNA2, ATR
strand displacement (GO:0000732)	6.47	2	DNA2, RBBP8
de novo centriole assembly (GO:0098535)	8.12	2	CEP63, CEP152
mitotic nuclear division (GO:0007067)	4.05	2	CEP63, RBBP8
organic cyclic compound biosynthetic process (GO:1901362)	1.66	2	DNA2, RBBP8
regulation of DNA metabolic process (GO:0051052)	3.87	2	DNA2, ATR
cellular protein metabolic process (GO:0044267)	1.63	2	TRAIP, ATR
negative regulation of macromolecule metabolic process (GO:0010605)	2.01	2	ATR, RBBP8
positive regulation of macromolecule metabolic process (GO:0010604)	1.81	2	DNA2, ATR
DNA double-strand break processing (GO:0000729)	6.78	2	DNA2, RBBP8
regulation of organelle organization (GO:0033043)	2.72	2	CENPJ, ATR
nuclear division (GO:0000280)	3.85	2	CEP63, RBBP8
negative regulation of cellular macromolecule biosynthetic process (GO:2000113)	2.6	2	ATR, RBBP8
regulation of biological quality (GO:0065008)	1.68	2	DNA2, ATR
heterocycle biosynthetic process (GO:0018130)	1.7	2	DNA2, RBBP8
positive regulation of DNA metabolic process (GO:0051054)	4.49	2	DNA2, ATR
positive regulation of nucleobase-containing compound metabolic process (GO:0045935)	2.35	2	DNA2, ATR
negative regulation of nucleobase-containing compound metabolic process (GO:0045934)	2.55	2	ATR, RBBP8
cellular protein modification process (GO:0006464)	1.79	2	TRAIP, ATR
macromolecule modification (GO:0043412)	1.73	2	TRAIP, ATR
protein modification process (GO:0036211)	1.79	2	TRAIP, ATR
negative regulation of nitrogen compound metabolic process (GO:0051172)	2.47	2	ATR, RBBP8
positive regulation of nitrogen compound metabolic process (GO:0051173)	2.29	2	DNA2, ATR
nucleobase-containing compound biosynthetic process (GO:0034654)	1.72	2	DNA2, RBBP8
response to chemical (GO:0042221)	1.98	2	ATR, RBBP8
localization (GO:0051179)	1.4	2	NIN, ATR
signal transduction in response to DNA damage (GO:0042770)	5.15	2	CENPJ, CEP63
cellular localization (GO:0051641)	2.32	2	ATR, NIN
DNA recombination (GO:0006310)	4.39	2	DNA2, RBBP8
cellular nitrogen compound biosynthetic process (GO:0044271)	1.59	2	DNA2, RBBP8
single-multicellular organism process (GO:0044707)	1.78	2	ATR, RBBP8
protein metabolic process (GO:0019538)	1.45	2	TRAIP, ATR
DNA synthesis involved in DNA repair (GO:0000731)	5.42	2	DNA2, RBBP8
regulation of DNA replication (GO:0006275)	5.02	2	DNA2, ATR
regulation of cellular component biogenesis (GO:0044087)	3.08	2	CENPJ, ATR
positive regulation of macromolecule biosynthetic process (GO:0010557)	2.39	2	DNA2, ATR
organelle fission (GO:0048285)	3.79	2	CEP63, RBBP8
aromatic compound biosynthetic process (GO:0019438)	1.7	2	DNA2, RBBP8
negative regulation of macromolecule biosynthetic process (GO:0010558)	2.53	2	ATR, RBBP8
DNA biosynthetic process (GO:0071897)	4.89	2	DNA2, RBBP8

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
cell cycle G2/M phase transition (GO:0044839)	-	4.82	0.007	CENPJ, CEP63, CEP152
G2/M transition of mitotic cell cycle (GO:0000086)	-	4.84	0.007	CENPJ, CEP63, CEP152
mitotic cell cycle process (GO:1903047)	-	3.12	0.006	CEP152, CEP63, ATR, CENPJ, RBBP8, DNA2
cell cycle phase transition (GO:0044770)	-	4.24	0.001	CENPJ, CEP63, RBBP8, CEP152, ATR
mitotic cell cycle phase transition (GO:0044772)	-	4.27	0.001	CENPJ, CEP63, RBBP8, CEP152, ATR
cell cycle process (GO:0022402)	-	2.75	0.0	CEP152, CEP63, ATR, CENPJ, RBBP8, DNA2
centriole assembly (GO:0098534)	-	6.78	0.0	CENPJ, CEP63, CEP152
cell cycle (GO:0007049)	-	3.14	0.039	CENPJ, CEP63, CEP152, DNA2, ATR
centrosome duplication (GO:0051298)	NEW	6.78	0.021	CENPJ, CEP152
microtubule nucleation (GO:0007020)	NEW	6.84	0.005	CENPJ, NIN
double-strand break repair (GO:0006302)	NEW	4.73	0.048	DNA2, RBBP8, ATR
recombinational repair (GO:0000725)	NEW	5.37	0.009	ATR, RBBP8, DNA2
double-strand break repair via homologous recombination (GO:0000724)	NEW	5.38	0.009	DNA2, RBBP8, ATR
DNA double-strand break processing (GO:0000729)	-	6.78	0.015	DNA2, RBBP8
microtubule organizing center organization (GO:0031023)	-	5.26	0.001	CENPJ, CEP63, CEP152
mitotic cell cycle (GO:0000278)	NEW	5.92	0.002	CENPJ, CEP63, CEP152, DNA2, ATR
centrosome organization (GO:0051297)	-	5.38	0.001	CENPJ, CEP63, CEP152
cellular response to DNA damage stimulus (GO:0006974)	-	3.17	0.035	CEP63, RBBP8, ATR, DNA2
DNA damage checkpoint (GO:0000077)	-	5.37	0.024	CEP63, RBBP8, ATR
organelle organization (GO:0006996)	-	2.02	0.008	CEP152, NIN, CEP63, CENPJ, RBBP8, DNA2
microtubule-based process (GO:0007017)	-	3.54	0.02	CEP152, CENPJ, CEP63, NIN, ATR
DNA catabolic process, exonucleolytic (GO:0000738)	NEW	9.04	0.015	DNA2, RBBP8
DNA integrity checkpoint (GO:0031570)	-	5.25	0.0	CEP63, RBBP8, DNA2, ATR
cell cycle checkpoint (GO:0000075)	-	4.79	0.0	CEP63, RBBP8, ATR, DNA2
single-organism organelle organization (GO:1902589)	-	2.68	0.001	CEP152, NIN, CEP63, CENPJ, RBBP8, DNA2
centriole replication (GO:0007099)	-	6.96	0.0	CENPJ, CEP63, CEP152
microtubule cytoskeleton organization (GO:0000226)	-	4.13	0.044	CENPJ, CEP63, ATR, NIN

GO - cellular component annotation: shared terms / NET-GE enrichment

Shared terms

GO	IC	Number of genes with the same GO	Genes
intracellular non-membrane-bounded organelle (GO:0043232)	1.76	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
cell part (GO:0044464)	0.11	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
intracellular organelle part (GO:0044446)	0.81	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
intracellular organelle (GO:0043229)	0.51	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
non-membrane-bounded organelle (GO:0043228)	1.76	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
intracellular part (GO:0044424)	0.28	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
organelle (GO:0043226)	0.4	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
organelle part (GO:0044422)	0.79	8	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
cytoplasmic part (GO:0044444)	0.82	7	CEP152, NIN, CEP63, ATR, CENPJ, TRAIP, DNA2
nuclear part (GO:0044428)	1.55	6	CEP152, NIN, ATR, RBBP8, TRAIP, DNA2
cytoplasm (GO:0005737)	1.01	5	CENPJ, TRAIP, CEP63, CEP152, NIN
cytoskeleton (GO:0005856)	2.55	4	CENPJ, CEP63, CEP152, NIN
intracellular membrane-bounded organelle (GO:0043231)	0.6	4	TRAIP, ATR, RBBP8, DNA2
centrosome (GO:0005813)	3.75	4	CENPJ, CEP63, CEP152, NIN
nucleus (GO:0005634)	1.07	4	TRAIP, DNA2, RBBP8, ATR
microtubule organizing center (GO:0005815)	3.42	4	CENPJ, CEP63, CEP152, NIN
nucleoplasm (GO:0005654)	1.89	4	CEP152, RBBP8, ATR, DNA2
cytoskeletal part (GO:0044430)	2.49	4	CENPJ, CEP63, CEP152, NIN
microtubule organizing center part (GO:0044450)	4.8	4	CENPJ, CEP63, CEP152, NIN
membrane-bounded organelle (GO:0043227)	0.47	4	TRAIP, ATR, RBBP8, DNA2
protein complex (GO:0043234)	1.51	3	CENPJ, DNA2, RBBP8
cytosol (GO:0005829)	1.68	3	CENPJ, CEP63, CEP152
macromolecular complex (GO:0032991)	1.35	3	CENPJ, DNA2, RBBP8
centriole (GO:0005814)	5.15	3	CENPJ, CEP63, CEP152
nucleolus (GO:0005730)	3.06	3	TRAIP, NIN, RBBP8
pericentriolar material (GO:0000242)	6.91	2	CEP152, NIN
supramolecular fiber (GO:0099512)	3.31	2	CENPJ, NIN
polymeric cytoskeletal fiber (GO:0099513)	3.31	2	CENPJ, NIN
chromosome (GO:0005694)	3.78	2	ATR, RBBP8
spindle pole (GO:0000922)	5.08	2	CEP63, NIN
chromosome, telomeric region (GO:0000781)	4.9	2	DNA2, ATR
nuclear chromosome part (GO:0044454)	3.67	2	DNA2, ATR
nuclear chromosome, telomeric region (GO:0000784)	5.16	2	DNA2, ATR
chromosomal part (GO:0044427)	3.18	2	DNA2, ATR
microtubule (GO:0005874)	3.81	2	CENPJ, NIN
chromosomal region (GO:0098687)	4.19	2	DNA2, ATR

NET-GE enrichment

Term	New enriched term	IC	P value	Genes
intracellular non-membrane-bounded organelle (GO:0043232)	-	1.76	0.0	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
centrosome (GO:0005813)	-	3.75	0.0	CEP152, NIN, CEP63, ATR, CENPJ, DNA2
centriole (GO:0005814)	-	5.15	0.0	CENPJ, CEP63, NIN
spindle pole (GO:0000922)	-	5.08	0.026	CEP63, NIN
intracellular organelle part (GO:0044446)	-	0.81	0.012	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
non-membrane-bounded organelle (GO:0043228)	-	1.76	0.0	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
nuclear part (GO:0044428)	-	1.55	0.007	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
cytoskeletal part (GO:0044430)	-	2.49	0.011	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, DNA2
microtubule organizing center part (GO:0044450)	-	4.8	0.0	CENPJ, CEP63, NIN
microtubule organizing center (GO:0005815)	-	3.42	0.001	CEP152, NIN, CEP63, ATR, CENPJ, DNA2
organelle part (GO:0044422)	-	0.79	0.015	CEP152, NIN, CEP63, ATR, CENPJ, RBBP8, TRAIP, DNA2
deuterosome (GO:0098536)	NEW	8.19	0.0	CENPJ, CEP152