Gene table of EIF4E : eukaryotic translation initiation factor 4E

Gene-disease associations table

Disease IDDisease nameSource of annotation with EIF4EOMIM linkNumber of associated genesgenes
PS209850AUTISM, SUSCEPTIBLITY TOOMIM link to OMIM 13CNTNAP2, PTCHD1, NLGN3, EN2, MET, MECP2, SHANK2, TMLHE, SLC9A9, CHD8, NLGN4X, EIF4E, RPL10

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Annotation of the gene EIF4E

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
HIF-1 signaling pathwayhsa040665.9
Insulin signaling pathwayhsa049105.55
RNA transporthsa030135.37
mTOR signaling pathwayhsa041506.72
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Immune SystemR-HSA-1682562.37
Cytokine Signaling in Immune systemR-HSA-12802153.74
IGF1R signaling cascadeR-HSA-24289244.85
Processing of Capped Intron-Containing Pre-mRNAR-HSA-722036.1
IRS-related events triggered by IGF1RR-HSA-24289284.85
IRS-mediated signallingR-HSA-1123994.87
Signaling by Insulin receptorR-HSA-747524.73
Deadenylation-dependent mRNA decayR-HSA-4299147.37
Insulin receptor signalling cascadeR-HSA-747514.85
Eukaryotic Translation InitiationR-HSA-726136.18
Translation initiation complex formationR-HSA-726497.2
Transport of the SLBP Dependant Mature mRNAR-HSA-15923010.4
Gene ExpressionR-HSA-741602.72
Transport of Mature mRNAs Derived from Intronless TranscriptsR-HSA-1592349.81
Transport of Mature mRNA derived from an Intron-Containing TranscriptR-HSA-1592368.4
TranslationR-HSA-727665.8
L13a-mediated translational silencing of Ceruloplasmin expressionR-HSA-1568276.28
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43SR-HSA-726627.18
Interferon SignalingR-HSA-9135314.95
Ribosomal scanning and start codon recognitionR-HSA-727027.2
GTP hydrolysis and joining of the 60S ribosomal subunitR-HSA-727066.27
mTORC1-mediated signallingR-HSA-1662088.52
Metabolism of proteinsR-HSA-3924993.41
Antiviral mechanism by IFN-stimulated genesR-HSA-11694106.83
ISG15 antiviral mechanismR-HSA-11694086.83
Transport of the SLBP independent Mature mRNAR-HSA-15922710.66
Deadenylation of mRNAR-HSA-4299478.46
mTOR signallingR-HSA-1651597.7
PI3K CascadeR-HSA-1097046.68
Cap-dependent Translation InitiationR-HSA-727376.18
PKB-mediated eventsR-HSA-1097037.66
Transport of Mature mRNA Derived from an Intronless TranscriptR-HSA-1592319.98
Transport of Mature Transcript to CytoplasmR-HSA-722028.18
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
protein bindingGO:00055150.46
organic cyclic compound bindingGO:00971591.05
poly(A) RNA bindingGO:00448222.69
translation factor activity, RNA bindingGO:00081355.07
enzyme bindingGO:00198992.27
heterocyclic compound bindingGO:19013631.06
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
RNA cap bindingGO:00003397.17
RNA bindingGO:00037232.36
translation initiation factor bindingGO:00313696.37
repressing transcription factor bindingGO:00704915.71
eukaryotic initiation factor 4G bindingGO:00313709.74
transcription factor bindingGO:00081343.46
translation initiation factor activityGO:00037435.7