Gene table of MET : MET proto-oncogene, receptor tyrosine kinase

Gene-disease associations table

Disease ID	Disease name	Source of annotation with MET	OMIM link	Number of associated genes	genes
114550	HEPATOCELLULAR CARCINOMA	OMIM, HUMSAVAR	link to OMIM	11	CDKN3, CASP8, MTUS1, TP53, MET, AXIN1, APC, IGF2R, PIK3CA, PDGFRL, CTNNB1
142340	DIAPHRAGMATIC HERNIA, CONGENITAL	ClinVar	link to OMIM	4	DES, FREM1, MET, PAX3
605074	RENAL CELL CARCINOMA, PAPILLARY, 1	ClinVar, OMIM, HUMSAVAR	link to OMIM	2	PRCC, MET
PS220290	DEAFNESS, AUTOSOMAL RECESSIVE	ClinVar, OMIM, HUMSAVAR	link to OMIM	60	CLIC5, KARS, OTOGL, CABP2, HGF, DFNB59, GIPC3, EPS8, MYO3A, CDH23, OTOF, ELMOD3, ESRRB, RDX, GJB2, GJB3, ESPN, ADCY1, CIB2, STRC, TMIE, S1PR2, FAM65B, TSPEAR, TBC1D24, SLC26A4, OTOG, COL11A2, MARVELD2, PNPT1, MYO15A, WHRN, CLDN14, MYO7A, GJB6, MET, TPRN, DCDC2, LRTOMT, TMC1, MYO6, ILDR1, MSRB3, SERPINB6, SLC26A5, ATP2B2, LHFPL5, SYNE4, GRXCR2, FOXI1, GRXCR1, LOXHD1, TECTA, PCDH15, TRIOBP, USH1C, KCNJ10, PTPRQ, TMPRSS3, OTOA
607278	OSTEOFIBROUS DYSPLASIA, SUSCEPTIBILITY TO	ClinVar, OMIM	link to OMIM	1	MET
PS209850	AUTISM, SUSCEPTIBLITY TO	ClinVar	link to OMIM	13	CNTNAP2, PTCHD1, NLGN3, EN2, MET, MECP2, SHANK2, TMLHE, SLC9A9, CHD8, NLGN4X, EIF4E, RPL10

Download the gene annotation in CSV format

Annotation of the gene MET

Associated genes in ENSEMBL

ENSG00000105976

Associated proteins - SwissProt Accession ID

P08581

Associated PDB IDs

Cytogenetic Band

7q31.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Epithelial cell signaling in Helicobacter pylori infection	hsa05120	6.58
Melanoma	hsa05218	6.56
Renal cell carcinoma	hsa05211	6.6
Ras signaling pathway	hsa04014	4.9
Malaria	hsa05144	7.15
Bacterial invasion of epithelial cells	hsa05100	6.34
Proteoglycans in cancer	hsa05205	5.02
MicroRNAs in cancer	hsa05206	5.38
Pathways in cancer	hsa05200	3.98
Transcriptional misregulation in cancer	hsa05202	5.21
Rap1 signaling pathway	hsa04015	4.97
Adherens junction	hsa04520	6.26
Central carbon metabolism in cancer	hsa05230	6.7
Endocytosis	hsa04144	4.92
Focal adhesion	hsa04510	4.92
Axon guidance	hsa04360	5.63
Cytokine-cytokine receptor interaction	hsa04060	4.67
PI3K-Akt signaling pathway	hsa04151	4.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Semaphorin interactions	R-HSA-373755	6.92
Axon guidance	R-HSA-422475	3.93
Sema4D mediated inhibition of cell attachment and migration	R-HSA-416550	9.98
Sema4D in semaphorin signaling	R-HSA-400685	8.23
Developmental Biology	R-HSA-1266738	3.48

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
purine nucleoside binding	GO:0001883	2.22
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
transferase activity	GO:0016740	1.95
nucleotide binding	GO:0000166	1.96
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
semaphorin receptor activity	GO:0017154	7.25
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
ribonucleoside binding	GO:0032549	2.22
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
transmembrane receptor activity	GO:0099600	2.53
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
hepatocyte growth factor-activated receptor activity	GO:0005008	9.74
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32